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Conserved domains on  [gi|194473654|ref|NP_001123972|]
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G2 and S phase-expressed protein 1 [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GTSE1_N pfam15259
G-2 and S-phase expressed 1; This family is the N-terminus of GTSE1 proteins. GTSE-1 (G2 and S ...
 29-172 3.23e-70

G-2 and S-phase expressed 1; This family is the N-terminus of GTSE1 proteins. GTSE-1 (G2 and S phase-expressed-1) protein is specifically expressed during S and G2 phases of the cell cycle. It is mainly localized to the microtubules and when overexpressed delays the G2 to M transition. the full protein negatively regulates p53 transactivation function, protein levels, and p53-dependent apoptosis. This domain family is found in eukaryotes, and is approximately 140 amino acids in length. There is a conserved FDFD sequence motif.


:

Pssm-ID: 464599 [Multi-domain]  Cd Length: 144  Bit Score: 226.05  E-value: 3.23e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194473654   29 FLLLEDEKFDFDLSLSSSSANEDDEVFFGPVGHKERCIAASLDLNRQVPEQPLAPGSGSPCTWSPLTGEKFVEVYKEAHL 108
Cdd:pfam15259   1 VLLLADEKFDFDLSLSPSSANEDDEVFVGPVGHKERCVAASVELNSQIPKQPLLPGSESPTSWSPLTGEKFVEVYKEAHL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 194473654  109 LALQIECHSRREVAQAAKPRSAVSQAKETFVQDSQLKISLFEKEQKRDKSPLSLKRETFCLPSS 172
Cdd:pfam15259  81 LALQLESSSKNEAAKAAQPEDPSSQGVEKFVQDSKLKLNLFEKEKEMEKSPRSIKRETYCVQDS 144
GTSE1_CTD super family cl41676
C-terminal domain of G2 and S phase-expressed protein 1; G2 and S phase-expressed protein 1 ...
 650-729 1.69e-03

C-terminal domain of G2 and S phase-expressed protein 1; G2 and S phase-expressed protein 1 (GTSE-1), also called protein B99 homolog, is a cell cycle-regulated protein mainly localized in the cytoplasm and apparently associated with microtubules. It may be involved in p53-induced cell cycle arrest in G2/M phase by interfering with microtubule rearrangements that are required to enter mitosis. Overexpression of GTSE-1 delays G2/M phase progression. GTSE-1 is a clathrin adaptor protein; it is recruited to the spindle by clathrin, which stabilizes microtubules by inhibiting the microtubule depolymerase MCAK. This model corresponds to a conserved domain at the C-terminus of GTSE-1, which is required for clathrin binding and is only conserved in vertebrates.


The actual alignment was detected with superfamily member cd21864:

Pssm-ID: 412061 [Multi-domain]  Cd Length: 56  Bit Score: 37.02  E-value: 1.69e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194473654 650 EGLLLDI-KLDQLTIAPEAGDRdladcPLIDFSNTPESNmalgpsswplidlimntpnmgRSDVGKPPkaELGQLIDLGS 728
Cdd:cd21864    4 ENLLVDFeANPEAHPAVQSEDR-----PLIDLSNTPDLN---------------------KVIPLKPS--VVGQLIDLSS 55


                 .
gi 194473654 729 P 729
Cdd:cd21864   56 P 56
 
Name Accession Description Interval E-value
GTSE1_N pfam15259
G-2 and S-phase expressed 1; This family is the N-terminus of GTSE1 proteins. GTSE-1 (G2 and S ...
 29-172 3.23e-70

G-2 and S-phase expressed 1; This family is the N-terminus of GTSE1 proteins. GTSE-1 (G2 and S phase-expressed-1) protein is specifically expressed during S and G2 phases of the cell cycle. It is mainly localized to the microtubules and when overexpressed delays the G2 to M transition. the full protein negatively regulates p53 transactivation function, protein levels, and p53-dependent apoptosis. This domain family is found in eukaryotes, and is approximately 140 amino acids in length. There is a conserved FDFD sequence motif.


Pssm-ID: 464599 [Multi-domain]  Cd Length: 144  Bit Score: 226.05  E-value: 3.23e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194473654   29 FLLLEDEKFDFDLSLSSSSANEDDEVFFGPVGHKERCIAASLDLNRQVPEQPLAPGSGSPCTWSPLTGEKFVEVYKEAHL 108
Cdd:pfam15259   1 VLLLADEKFDFDLSLSPSSANEDDEVFVGPVGHKERCVAASVELNSQIPKQPLLPGSESPTSWSPLTGEKFVEVYKEAHL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 194473654  109 LALQIECHSRREVAQAAKPRSAVSQAKETFVQDSQLKISLFEKEQKRDKSPLSLKRETFCLPSS 172
Cdd:pfam15259  81 LALQLESSSKNEAAKAAQPEDPSSQGVEKFVQDSKLKLNLFEKEKEMEKSPRSIKRETYCVQDS 144
GTSE1_CTD cd21864
C-terminal domain of G2 and S phase-expressed protein 1; G2 and S phase-expressed protein 1 ...
 650-729 1.69e-03

C-terminal domain of G2 and S phase-expressed protein 1; G2 and S phase-expressed protein 1 (GTSE-1), also called protein B99 homolog, is a cell cycle-regulated protein mainly localized in the cytoplasm and apparently associated with microtubules. It may be involved in p53-induced cell cycle arrest in G2/M phase by interfering with microtubule rearrangements that are required to enter mitosis. Overexpression of GTSE-1 delays G2/M phase progression. GTSE-1 is a clathrin adaptor protein; it is recruited to the spindle by clathrin, which stabilizes microtubules by inhibiting the microtubule depolymerase MCAK. This model corresponds to a conserved domain at the C-terminus of GTSE-1, which is required for clathrin binding and is only conserved in vertebrates.


Pssm-ID: 412061 [Multi-domain]  Cd Length: 56  Bit Score: 37.02  E-value: 1.69e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194473654 650 EGLLLDI-KLDQLTIAPEAGDRdladcPLIDFSNTPESNmalgpsswplidlimntpnmgRSDVGKPPkaELGQLIDLGS 728
Cdd:cd21864    4 ENLLVDFeANPEAHPAVQSEDR-----PLIDLSNTPDLN---------------------KVIPLKPS--VVGQLIDLSS 55


                 .
gi 194473654 729 P 729
Cdd:cd21864   56 P 56
 
Name Accession Description Interval E-value
GTSE1_N pfam15259
G-2 and S-phase expressed 1; This family is the N-terminus of GTSE1 proteins. GTSE-1 (G2 and S ...
 29-172 3.23e-70

G-2 and S-phase expressed 1; This family is the N-terminus of GTSE1 proteins. GTSE-1 (G2 and S phase-expressed-1) protein is specifically expressed during S and G2 phases of the cell cycle. It is mainly localized to the microtubules and when overexpressed delays the G2 to M transition. the full protein negatively regulates p53 transactivation function, protein levels, and p53-dependent apoptosis. This domain family is found in eukaryotes, and is approximately 140 amino acids in length. There is a conserved FDFD sequence motif.


Pssm-ID: 464599 [Multi-domain]  Cd Length: 144  Bit Score: 226.05  E-value: 3.23e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194473654   29 FLLLEDEKFDFDLSLSSSSANEDDEVFFGPVGHKERCIAASLDLNRQVPEQPLAPGSGSPCTWSPLTGEKFVEVYKEAHL 108
Cdd:pfam15259   1 VLLLADEKFDFDLSLSPSSANEDDEVFVGPVGHKERCVAASVELNSQIPKQPLLPGSESPTSWSPLTGEKFVEVYKEAHL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 194473654  109 LALQIECHSRREVAQAAKPRSAVSQAKETFVQDSQLKISLFEKEQKRDKSPLSLKRETFCLPSS 172
Cdd:pfam15259  81 LALQLESSSKNEAAKAAQPEDPSSQGVEKFVQDSKLKLNLFEKEKEMEKSPRSIKRETYCVQDS 144
GTSE1_CTD cd21864
C-terminal domain of G2 and S phase-expressed protein 1; G2 and S phase-expressed protein 1 ...
 650-729 1.69e-03

C-terminal domain of G2 and S phase-expressed protein 1; G2 and S phase-expressed protein 1 (GTSE-1), also called protein B99 homolog, is a cell cycle-regulated protein mainly localized in the cytoplasm and apparently associated with microtubules. It may be involved in p53-induced cell cycle arrest in G2/M phase by interfering with microtubule rearrangements that are required to enter mitosis. Overexpression of GTSE-1 delays G2/M phase progression. GTSE-1 is a clathrin adaptor protein; it is recruited to the spindle by clathrin, which stabilizes microtubules by inhibiting the microtubule depolymerase MCAK. This model corresponds to a conserved domain at the C-terminus of GTSE-1, which is required for clathrin binding and is only conserved in vertebrates.


Pssm-ID: 412061 [Multi-domain]  Cd Length: 56  Bit Score: 37.02  E-value: 1.69e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194473654 650 EGLLLDI-KLDQLTIAPEAGDRdladcPLIDFSNTPESNmalgpsswplidlimntpnmgRSDVGKPPkaELGQLIDLGS 728
Cdd:cd21864    4 ENLLVDFeANPEAHPAVQSEDR-----PLIDLSNTPDLN---------------------KVIPLKPS--VVGQLIDLSS 55


                 .
gi 194473654 729 P 729
Cdd:cd21864   56 P 56
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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