NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|190570186|ref|NP_001122064|]
View 

proteasome assembly chaperone 4 isoform a [Homo sapiens]

Protein Classification

proteasome assembly chaperone 4 family protein( domain architecture ID 11240890)

proteasome assembly chaperone 4 (PAC-4) family protein similar to human PAC-4, also called PSMG4, that is a chaperone protein which promotes assembly of the 20S proteasome

Gene Ontology:  GO:0044183|GO:0043248
PubMed:  15571806|20074030|18786393|31067643
SCOP:  4007613

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PAC4 pfam16093
Proteasome assembly chaperone 4; PAC4 or proteasome assembly chaperone 4 protein promotes ...
 30-136 9.01e-19

Proteasome assembly chaperone 4; PAC4 or proteasome assembly chaperone 4 protein promotes assembly of the 20S proteasome. It interacts with PSMG3. It associates with alpha subunits of the 20S proteasome. At the very C-terminal is a crucial HbYX or hydrophobic-tyrosine-X sequence motif that, in proteasome activators, opens the 20S proteasome entry pore.


:

Pssm-ID: 465017  Cd Length: 72  Bit Score: 75.30  E-value: 9.01e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190570186   30 VMRLTDSLFLWVGAT--PHLRNLAVAMCSRYDSIP-VSTSLLGDT-SDTTSTGLAQRLglggktglacecgvewglskgh 105
Cdd:pfam16093   1 LTKLAKSIFLWVGTAspEELGSLAVAMPTRYNSTPpLSTTLLGDPsSDDFSTRLAQRL---------------------- 58

                          90       100       110
                  ....*....|....*....|....*....|.
gi 190570186  106 eaecstlptpqhtscgpARKTNKQVFVSYNL 136
Cdd:pfam16093  59 -----------------ARRTGKQVYVSCNL 72
 
Name Accession Description Interval E-value
PAC4 pfam16093
Proteasome assembly chaperone 4; PAC4 or proteasome assembly chaperone 4 protein promotes ...
 30-136 9.01e-19

Proteasome assembly chaperone 4; PAC4 or proteasome assembly chaperone 4 protein promotes assembly of the 20S proteasome. It interacts with PSMG3. It associates with alpha subunits of the 20S proteasome. At the very C-terminal is a crucial HbYX or hydrophobic-tyrosine-X sequence motif that, in proteasome activators, opens the 20S proteasome entry pore.


Pssm-ID: 465017  Cd Length: 72  Bit Score: 75.30  E-value: 9.01e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190570186   30 VMRLTDSLFLWVGAT--PHLRNLAVAMCSRYDSIP-VSTSLLGDT-SDTTSTGLAQRLglggktglacecgvewglskgh 105
Cdd:pfam16093   1 LTKLAKSIFLWVGTAspEELGSLAVAMPTRYNSTPpLSTTLLGDPsSDDFSTRLAQRL---------------------- 58

                          90       100       110
                  ....*....|....*....|....*....|.
gi 190570186  106 eaecstlptpqhtscgpARKTNKQVFVSYNL 136
Cdd:pfam16093  59 -----------------ARRTGKQVYVSCNL 72
 
Name Accession Description Interval E-value
PAC4 pfam16093
Proteasome assembly chaperone 4; PAC4 or proteasome assembly chaperone 4 protein promotes ...
 30-136 9.01e-19

Proteasome assembly chaperone 4; PAC4 or proteasome assembly chaperone 4 protein promotes assembly of the 20S proteasome. It interacts with PSMG3. It associates with alpha subunits of the 20S proteasome. At the very C-terminal is a crucial HbYX or hydrophobic-tyrosine-X sequence motif that, in proteasome activators, opens the 20S proteasome entry pore.


Pssm-ID: 465017  Cd Length: 72  Bit Score: 75.30  E-value: 9.01e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190570186   30 VMRLTDSLFLWVGAT--PHLRNLAVAMCSRYDSIP-VSTSLLGDT-SDTTSTGLAQRLglggktglacecgvewglskgh 105
Cdd:pfam16093   1 LTKLAKSIFLWVGTAspEELGSLAVAMPTRYNSTPpLSTTLLGDPsSDDFSTRLAQRL---------------------- 58

                          90       100       110
                  ....*....|....*....|....*....|.
gi 190570186  106 eaecstlptpqhtscgpARKTNKQVFVSYNL 136
Cdd:pfam16093  59 -----------------ARRTGKQVYVSCNL 72
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH