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Conserved domains on  [gi|190570230|ref|NP_001122042|]
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uncharacterized protein LOC100149164 [Danio rerio]

Protein Classification

C2H2-type zinc finger family protein( domain architecture ID 705934)

Cys2His2 (C2H2)-type zinc finger family protein may be involved in transcriptional regulation

Gene Ontology:  GO:0046872

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SFP1 super family cl25788
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 163-243 6.55e-07

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


The actual alignment was detected with superfamily member COG5189:

Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 49.72  E-value: 6.55e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190570230 163 GERPFAC--VQCDKTYFNQHDLNQHlrdchsdKKHGcyLCGNEFTRQSSLQKHMRIHTGERPYSCPHCGKTFSYKHSMKM 240
Cdd:COG5189  346 DGKPYKCpvEGCNKKYKNQNGLKYH-------MLHG--HQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ...
gi 190570230 241 HVK 243
Cdd:COG5189  417 HRK 419
SFP1 super family cl25788
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 7-190 1.44e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


The actual alignment was detected with superfamily member COG5189:

Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.40  E-value: 1.44e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190570230   7 NEESLQGDPESKSTNNDVETLVLSKTEGSAALFCRRLKYR----VKTDQTSDQSSSDTDTEDELPISTSPTPGEDLICKL 82
Cdd:COG5189  248 EDVDLMDDDILGPSNEEMLYKYISPSQGSAELFEESSLGFdyefIHKSVGNKEIRGGISTGEMIDVRKLPCTNSSSNGKL 327

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190570230  83 C-GSEfgSNISMVRHMRIHTGETPYICEV--CGKGFKRQGWLKEHfRVHtgnkrkrekrlscDQCEMKFNSSTALRSHLN 159
Cdd:COG5189  328 AhGGE--RNIDTPSRMLKVKDGKPYKCPVegCNKKYKNQNGLKYH-MLH-------------GHQNQKLHENPSPEKMNI 391

                        170       180       190
                 ....*....|....*....|....*....|.
gi 190570230 160 KHRGERPFACVQCDKTYFNQHDLNQHLRDCH 190
Cdd:COG5189  392 FSAKDKPYRCEVCDKRYKNLNGLKYHRKHSH 422
 
Name Accession Description Interval E-value
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 163-243 6.55e-07

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 49.72  E-value: 6.55e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190570230 163 GERPFAC--VQCDKTYFNQHDLNQHlrdchsdKKHGcyLCGNEFTRQSSLQKHMRIHTGERPYSCPHCGKTFSYKHSMKM 240
Cdd:COG5189  346 DGKPYKCpvEGCNKKYKNQNGLKYH-------MLHG--HQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ...
gi 190570230 241 HVK 243
Cdd:COG5189  417 HRK 419
zf-H2C2_2 pfam13465
Zinc-finger double domain;
209-234 1.25e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.20  E-value: 1.25e-05
                          10        20
                  ....*....|....*....|....*.
gi 190570230  209 SLQKHMRIHTGERPYSCPHCGKTFSY 234
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 7-190 1.44e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.40  E-value: 1.44e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190570230   7 NEESLQGDPESKSTNNDVETLVLSKTEGSAALFCRRLKYR----VKTDQTSDQSSSDTDTEDELPISTSPTPGEDLICKL 82
Cdd:COG5189  248 EDVDLMDDDILGPSNEEMLYKYISPSQGSAELFEESSLGFdyefIHKSVGNKEIRGGISTGEMIDVRKLPCTNSSSNGKL 327

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190570230  83 C-GSEfgSNISMVRHMRIHTGETPYICEV--CGKGFKRQGWLKEHfRVHtgnkrkrekrlscDQCEMKFNSSTALRSHLN 159
Cdd:COG5189  328 AhGGE--RNIDTPSRMLKVKDGKPYKCPVegCNKKYKNQNGLKYH-MLH-------------GHQNQKLHENPSPEKMNI 391

                        170       180       190
                 ....*....|....*....|....*....|.
gi 190570230 160 KHRGERPFACVQCDKTYFNQHDLNQHLRDCH 190
Cdd:COG5189  392 FSAKDKPYRCEVCDKRYKNLNGLKYHRKHSH 422
zf-H2C2_2 pfam13465
Zinc-finger double domain;
92-117 2.43e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 2.43e-03
                          10        20
                  ....*....|....*....|....*.
gi 190570230   92 SMVRHMRIHTGETPYICEVCGKGFKR 117
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 194-242 3.99e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 35.22  E-value: 3.99e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 190570230 194 KHGCYLCGNEFTRQSSLQKHMRIHTgerpYSCPHCGKTFSYKHSMKMHV 242
Cdd:cd20908    1 KPWCYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHC 45
 
Name Accession Description Interval E-value
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 163-243 6.55e-07

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 49.72  E-value: 6.55e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190570230 163 GERPFAC--VQCDKTYFNQHDLNQHlrdchsdKKHGcyLCGNEFTRQSSLQKHMRIHTGERPYSCPHCGKTFSYKHSMKM 240
Cdd:COG5189  346 DGKPYKCpvEGCNKKYKNQNGLKYH-------MLHG--HQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ...
gi 190570230 241 HVK 243
Cdd:COG5189  417 HRK 419
zf-H2C2_2 pfam13465
Zinc-finger double domain;
209-234 1.25e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.20  E-value: 1.25e-05
                          10        20
                  ....*....|....*....|....*.
gi 190570230  209 SLQKHMRIHTGERPYSCPHCGKTFSY 234
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 7-190 1.44e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.40  E-value: 1.44e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190570230   7 NEESLQGDPESKSTNNDVETLVLSKTEGSAALFCRRLKYR----VKTDQTSDQSSSDTDTEDELPISTSPTPGEDLICKL 82
Cdd:COG5189  248 EDVDLMDDDILGPSNEEMLYKYISPSQGSAELFEESSLGFdyefIHKSVGNKEIRGGISTGEMIDVRKLPCTNSSSNGKL 327

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190570230  83 C-GSEfgSNISMVRHMRIHTGETPYICEV--CGKGFKRQGWLKEHfRVHtgnkrkrekrlscDQCEMKFNSSTALRSHLN 159
Cdd:COG5189  328 AhGGE--RNIDTPSRMLKVKDGKPYKCPVegCNKKYKNQNGLKYH-MLH-------------GHQNQKLHENPSPEKMNI 391

                        170       180       190
                 ....*....|....*....|....*....|.
gi 190570230 160 KHRGERPFACVQCDKTYFNQHDLNQHLRDCH 190
Cdd:COG5189  392 FSAKDKPYRCEVCDKRYKNLNGLKYHRKHSH 422
zf-H2C2_2 pfam13465
Zinc-finger double domain;
92-117 2.43e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 2.43e-03
                          10        20
                  ....*....|....*....|....*.
gi 190570230   92 SMVRHMRIHTGETPYICEVCGKGFKR 117
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 194-242 3.99e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 35.22  E-value: 3.99e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 190570230 194 KHGCYLCGNEFTRQSSLQKHMRIHTgerpYSCPHCGKTFSYKHSMKMHV 242
Cdd:cd20908    1 KPWCYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHC 45
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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