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Conserved domains on  [gi|190570318|ref|NP_001122001|]
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7SK snRNA methylphosphate capping enzyme [Danio rerio]

Protein Classification

BCDIN3 domain-containing RNA methyltransferase( domain architecture ID 11224030)

BCDIN3 domain-containing RNA methyltransferase acts as O-methyltransferase that specifically monomethylates 5'-monophosphate of cytoplasmic histidyl tRNA (tRNA(His)), acting as a capping enzyme by protecting tRNA(His) from cleavage by DICER1

CATH:  2.20.25.110
EC:  2.1.1.-
Gene Ontology:  GO:0008173|GO:0001510|GO:0032259|GO:0008757|GO:0008168|GO:1904047|GO:0008171|GO:0090486
PubMed:  12504684|12826405
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Bin3 pfam06859
Bicoid-interacting protein 3 (Bin3); This family represents a conserved region of ...
 588-695 2.95e-65

Bicoid-interacting protein 3 (Bin3); This family represents a conserved region of approximately 120 residues within eukaryotic Bicoid-interacting protein 3 (Bin3). Bin3, which shows similarity to a number of protein methyltransferases that modify RNA-binding proteins, interacts with Bicoid, which itself directs pattern formation in the early Drosophila embryo. The interaction might allow Bicoid to switch between its dual roles in transcription and translation. Note that family members contain a conserved HLN motif.


:

Pssm-ID: 462022  Cd Length: 109  Bit Score: 210.86  E-value: 2.95e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190570318  588 YDVILCLSVTKWVHLNWGDAGLKRFFHRVYKHLRPGGLFILEPQPWSSYNKRKKLTEAICKNYHSIRLKPDQFSSFLTTE 667
Cdd:pfam06859   1 YDVILCLSVTKWIHLNWGDEGLKRFFKRIYSLLRPGGVLILEPQPWKSYKKAKRLSETIKANYKTIQLRPEDFEEYLLSE 80

                          90       100
                  ....*....|....*....|....*....
gi 190570318  668 VGFSSYELIG-TSQNYSKGFQRPISLYHK 695
Cdd:pfam06859  81 VGFESVEELGsTPEGKSKGFDRPIYLFRK 109
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
400-443 1.43e-08

Trans-aconitate methyltransferase [Energy production and conversion];


:

Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 52.90  E-value: 1.43e-08
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 190570318 400 RGKDVLDLGCNTGHLTLFIAKNWRPASIVGLDIDGSLIHAARQN 443
Cdd:COG4106    1 PPRRVLDLGCGTGRLTALLAERFPGARVTGVDLSPEMLARARAR 44
 
Name Accession Description Interval E-value
Bin3 pfam06859
Bicoid-interacting protein 3 (Bin3); This family represents a conserved region of ...
 588-695 2.95e-65

Bicoid-interacting protein 3 (Bin3); This family represents a conserved region of approximately 120 residues within eukaryotic Bicoid-interacting protein 3 (Bin3). Bin3, which shows similarity to a number of protein methyltransferases that modify RNA-binding proteins, interacts with Bicoid, which itself directs pattern formation in the early Drosophila embryo. The interaction might allow Bicoid to switch between its dual roles in transcription and translation. Note that family members contain a conserved HLN motif.


Pssm-ID: 462022  Cd Length: 109  Bit Score: 210.86  E-value: 2.95e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190570318  588 YDVILCLSVTKWVHLNWGDAGLKRFFHRVYKHLRPGGLFILEPQPWSSYNKRKKLTEAICKNYHSIRLKPDQFSSFLTTE 667
Cdd:pfam06859   1 YDVILCLSVTKWIHLNWGDEGLKRFFKRIYSLLRPGGVLILEPQPWKSYKKAKRLSETIKANYKTIQLRPEDFEEYLLSE 80

                          90       100
                  ....*....|....*....|....*....
gi 190570318  668 VGFSSYELIG-TSQNYSKGFQRPISLYHK 695
Cdd:pfam06859  81 VGFESVEELGsTPEGKSKGFDRPIYLFRK 109
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
400-443 1.43e-08

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 52.90  E-value: 1.43e-08
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 190570318 400 RGKDVLDLGCNTGHLTLFIAKNWRPASIVGLDIDGSLIHAARQN 443
Cdd:COG4106    1 PPRRVLDLGCGTGRLTALLAERFPGARVTGVDLSPEMLARARAR 44
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 404-455 5.24e-08

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 51.03  E-value: 5.24e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 190570318  404 VLDLGCNTGHLTLFIAKNWRpASIVGLDIDGSLIHAARQNIRHYLSEVQVQH 455
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGG-ARVTGVDLSPEMLERARERAAEAGLNVEFVQ 51
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 403-450 2.20e-05

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 43.96  E-value: 2.20e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 190570318 403 DVLDLGCNTGHLTLFIAKnWRPASIVGLDIDGSLIHAARQNIRHYLSE 450
Cdd:cd02440    1 RVLDLGCGTGALALALAS-GPGARVTGVDISPVALELARKAAAALLAD 47
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
570-628 1.53e-04

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 43.06  E-value: 1.53e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 190570318 570 KGNYV--LESDVL-LQTQREEYDVILCLSVtkwvhLNWGDAgLKRFFHRVYKHLRPGGLFIL 628
Cdd:COG4976   87 KGVYDrlLVADLAdLAEPDGRFDLIVAADV-----LTYLGD-LAAVFAGVARALKPGGLFIF 142
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 391-454 4.97e-04

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 42.45  E-value: 4.97e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 190570318 391 IRVMNPdwFRGKDVLDLGCNTGHLTLFIAKN-WRPASIVGLDIDGSLIHAARQNIRHYLSEVQVQ 454
Cdd:PRK00216  44 IKWLGV--RPGDKVLDLACGTGDLAIALAKAvGKTGEVVGLDFSEGMLAVGREKLRDLGLSGNVE 106
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 562-629 1.17e-03

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 38.95  E-value: 1.17e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 190570318 562 FPANVTFIKGNyVLEsdvLLQTQREEYDVILCLSVTKWVHLNWgdaglKRFFHRVYKHLRPGGLFILE 629
Cdd:cd02440   45 LADNVEVLKGD-AEE---LPPEADESFDVIISDPPLHHLVEDL-----ARFLEEARRLLKPGGVLVLT 103
 
Name Accession Description Interval E-value
Bin3 pfam06859
Bicoid-interacting protein 3 (Bin3); This family represents a conserved region of ...
 588-695 2.95e-65

Bicoid-interacting protein 3 (Bin3); This family represents a conserved region of approximately 120 residues within eukaryotic Bicoid-interacting protein 3 (Bin3). Bin3, which shows similarity to a number of protein methyltransferases that modify RNA-binding proteins, interacts with Bicoid, which itself directs pattern formation in the early Drosophila embryo. The interaction might allow Bicoid to switch between its dual roles in transcription and translation. Note that family members contain a conserved HLN motif.


Pssm-ID: 462022  Cd Length: 109  Bit Score: 210.86  E-value: 2.95e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190570318  588 YDVILCLSVTKWVHLNWGDAGLKRFFHRVYKHLRPGGLFILEPQPWSSYNKRKKLTEAICKNYHSIRLKPDQFSSFLTTE 667
Cdd:pfam06859   1 YDVILCLSVTKWIHLNWGDEGLKRFFKRIYSLLRPGGVLILEPQPWKSYKKAKRLSETIKANYKTIQLRPEDFEEYLLSE 80

                          90       100
                  ....*....|....*....|....*....
gi 190570318  668 VGFSSYELIG-TSQNYSKGFQRPISLYHK 695
Cdd:pfam06859  81 VGFESVEELGsTPEGKSKGFDRPIYLFRK 109
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
400-443 1.43e-08

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 52.90  E-value: 1.43e-08
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 190570318 400 RGKDVLDLGCNTGHLTLFIAKNWRPASIVGLDIDGSLIHAARQN 443
Cdd:COG4106    1 PPRRVLDLGCGTGRLTALLAERFPGARVTGVDLSPEMLARARAR 44
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 404-455 5.24e-08

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 51.03  E-value: 5.24e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 190570318  404 VLDLGCNTGHLTLFIAKNWRpASIVGLDIDGSLIHAARQNIRHYLSEVQVQH 455
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGG-ARVTGVDLSPEMLERARERAAEAGLNVEFVQ 51
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 400-455 9.28e-08

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 51.53  E-value: 9.28e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 190570318 400 RGKDVLDLGCNTGHLTLFIAKnwRPASIVGLDIDGSLIHAARQNIRHYLSEVQVQH 455
Cdd:COG2226   22 PGARVLDLGCGTGRLALALAE--RGARVTGVDISPEMLELARERAAEAGLNVEFVV 75
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 405-447 2.87e-07

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 48.90  E-value: 2.87e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 190570318  405 LDLGCNTGHLTLFIAKNWRPASIVGLDIDGSLIHAARQNIRHY 447
Cdd:pfam08242   1 LEIGCGTGTLLRALLEALPGLEYTGLDISPAALEAARERLAAL 43
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 401-456 5.23e-07

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 49.72  E-value: 5.23e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 190570318  401 GKDVLDLGCNTGHLTLFIAKNWRP-ASIVGLDIDGSLIHAARQNIR-HYLSEVQVQHS 456
Cdd:pfam13847   4 GMRVLDLGCGTGHLSFELAEELGPnAEVVGIDISEEAIEKARENAQkLGFDNVEFEQG 61
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 388-446 8.52e-07

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 48.48  E-value: 8.52e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 190570318 388 DPRIRVMNPDWF-RGKDVLDLGCNTGHLTLFIAKnwRPASIVGLDIDGSLIHAARQNIRH 446
Cdd:COG2227   11 DRRLAALLARLLpAGGRVLDVGCGTGRLALALAR--RGADVTGVDISPEALEIARERAAE 68
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 400-446 2.13e-06

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 49.37  E-value: 2.13e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 190570318 400 RGKDVLDLGCNTGHLTLFIAKNWRPASIVGLDIDGSLIHAARQNIRH 446
Cdd:COG4123   37 KGGRVLDLGTGTGVIALMLAQRSPGARITGVEIQPEAAELARRNVAL 83
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 400-455 8.69e-06

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 47.22  E-value: 8.69e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 190570318 400 RGKDVLDLGCNTGHLTLFIAKNWRpASIVGLDIDGSLIHAARQNIRHY-LSEVQVQH 455
Cdd:COG0500   26 KGGRVLDLGCGTGRNLLALAARFG-GRVIGIDLSPEAIALARARAAKAgLGNVEFLV 81
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 403-450 2.20e-05

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 43.96  E-value: 2.20e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 190570318 403 DVLDLGCNTGHLTLFIAKnWRPASIVGLDIDGSLIHAARQNIRHYLSE 450
Cdd:cd02440    1 RVLDLGCGTGALALALAS-GPGARVTGVDISPVALELARKAAAALLAD 47
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
400-442 1.48e-04

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 43.06  E-value: 1.48e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 190570318 400 RGKDVLDLGCNTGHLTLFIAKnwRPASIVGLDIDGSLIHAARQ 442
Cdd:COG4976   46 PFGRVLDLGCGTGLLGEALRP--RGYRLTGVDLSEEMLAKARE 86
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
570-628 1.53e-04

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 43.06  E-value: 1.53e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 190570318 570 KGNYV--LESDVL-LQTQREEYDVILCLSVtkwvhLNWGDAgLKRFFHRVYKHLRPGGLFIL 628
Cdd:COG4976   87 KGVYDrlLVADLAdLAEPDGRFDLIVAADV-----LTYLGD-LAAVFAGVARALKPGGLFIF 142
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 391-454 4.97e-04

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 42.45  E-value: 4.97e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 190570318 391 IRVMNPdwFRGKDVLDLGCNTGHLTLFIAKN-WRPASIVGLDIDGSLIHAARQNIRHYLSEVQVQ 454
Cdd:PRK00216  44 IKWLGV--RPGDKVLDLACGTGDLAIALAKAvGKTGEVVGLDFSEGMLAVGREKLRDLGLSGNVE 106
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 401-456 8.84e-04

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 40.94  E-value: 8.84e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 190570318 401 GKDVLDLGCNTGHLTLFIAKNWRPASIVGLDIDGSLIHAARQNIRHY-LSEVQVQHS 456
Cdd:COG2813   50 GGRVLDLGCGYGVIGLALAKRNPEARVTLVDVNARAVELARANAAANgLENVEVLWS 106
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 564-630 8.97e-04

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 41.06  E-value: 8.97e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 190570318 564 ANVTFIKGNYvlesDVLLQTQREEYDVILCLSVtkWVHLNwgDAGLKRFFHRVYKHLRPGGLFILEP 630
Cdd:COG0500   75 GNVEFLVADL----AELDPLPAESFDLVVAFGV--LHHLP--PEEREALLRELARALKPGGVLLLSA 133
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 401-445 1.01e-03

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 40.30  E-value: 1.01e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 190570318 401 GKDVLDLGCNTGHLTLFIAKNWRpASIVGLDIDGSLIHAARQNIR 445
Cdd:COG2230   52 GMRVLDIGCGWGGLALYLARRYG-VRVTGVTLSPEQLEYARERAA 95
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 565-628 1.04e-03

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 40.30  E-value: 1.04e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 190570318 565 NVTFIKGNYvleSDVLLQtqrEEYDVILCLSVTKWVhlnwGDAGLKRFFHRVYKHLRPGGLFIL 628
Cdd:COG2230  102 RVEVRLADY---RDLPAD---GQFDAIVSIGMFEHV----GPENYPAYFAKVARLLKPGGRLLL 155
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 562-629 1.17e-03

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 38.95  E-value: 1.17e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 190570318 562 FPANVTFIKGNyVLEsdvLLQTQREEYDVILCLSVTKWVHLNWgdaglKRFFHRVYKHLRPGGLFILE 629
Cdd:cd02440   45 LADNVEVLKGD-AEE---LPPEADESFDVIISDPPLHHLVEDL-----ARFLEEARRLLKPGGVLVLT 103
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 405-445 1.27e-03

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 38.41  E-value: 1.27e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 190570318  405 LDLGCNTGHLTLFIAKnwRPASIVGLDIDGSLIHAARQNIR 445
Cdd:pfam08241   1 LDVGCGTGLLTELLAR--LGARVTGVDISPEMLELAREKAP 39
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 565-629 1.29e-03

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 39.23  E-value: 1.29e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 190570318 565 NVTFIKGNyvLESdvlLQTQREEYDVILCLSVtkWVHLnwgdAGLKRFFHRVYKHLRPGGLFILE 629
Cdd:COG2227   70 NVDFVQGD--LED---LPLEDGSFDLVICSEV--LEHL----PDPAALLRELARLLKPGGLLLLS 123
PLN02672 PLN02672
methionine S-methyltransferase
 399-448 1.34e-03

methionine S-methyltransferase


Pssm-ID: 215360 [Multi-domain]  Cd Length: 1082  Bit Score: 42.07  E-value: 1.34e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 190570318  399 FRGKDVLDLGCNTGHLTLFIAKNWRPASIVGLDIDGSLIHAARQNIrhYL 448
Cdd:PLN02672  117 FRDKTVAELGCGNGWISIAIAEKWLPSKVYGLDINPRAVKVAWINL--YL 164
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 396-446 2.00e-03

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 39.33  E-value: 2.00e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 190570318  396 PDWFRGKDVLDLGCNTGHLTLFIAKNWrpASIVGLDIDGSLIHAARQNIRH 446
Cdd:pfam13489  18 PKLPSPGRVLDFGCGTGIFLRLLRAQG--FSVTGVDPSPIAIERALLNVRF 66
PrmA COG2264
Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];
399-445 2.67e-03

Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441865 [Multi-domain]  Cd Length: 284  Bit Score: 40.16  E-value: 2.67e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 190570318 399 FRGKDVLDLGCNTGHLTLFIAKNWrPASIVGLDIDGSLIHAARQNIR 445
Cdd:COG2264  147 KPGKTVLDVGCGSGILAIAAAKLG-AKRVLAVDIDPVAVEAARENAE 192
COG2263 COG2263
Predicted RNA methylase [General function prediction only];
394-453 3.57e-03

Predicted RNA methylase [General function prediction only];


Pssm-ID: 441864 [Multi-domain]  Cd Length: 199  Bit Score: 39.12  E-value: 3.57e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 190570318 394 MNPDwFRGKDVLDLGCNTGHLTLFiAKNWRPASIVGLDIDGSLIHAARQNIRHYLSEVQV 453
Cdd:COG2263   40 LRGD-IEGKTVLDLGCGTGMLAIG-AALLGAKKVVGVDIDPEALEIARENAERLGVRVDF 97
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 400-456 4.01e-03

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 38.73  E-value: 4.01e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 190570318  400 RGKDVLDLGCNTGHLTLFIAKNWRPASIVGLDIDGSLIHAARQNIR-HYLSEVQVQHS 456
Cdd:pfam05175  31 LSGKVLDLGCGAGVLGAALAKESPDAELTMVDINARALESARENLAaNGLENGEVVAS 88
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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