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Conserved domains on  [gi|190360571|ref|NP_001121904|]
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cytosolic beta-glucosidase isoform b [Homo sapiens]

Protein Classification

glycoside hydrolase family 1 protein( domain architecture ID 1903400)

glycoside hydrolase family 1 protein such as 6-phospho-beta-glucosidase, which catalyzes the hydrolysis of 6-phospho-beta-D-glucosyl-(1,4)-D-glucose into glucose-6-phosphate (G-6-P) and D-glucose, or beta-galactosidase, which hydrolyzes terminal non-reducing beta-D-galactose residues in beta-D-galactosides

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BglB super family cl43707
Beta-glucosidase/6-phospho-beta-glucosidase/beta-galactosidase [Carbohydrate transport and ...
 2-98 4.73e-43

Beta-glucosidase/6-phospho-beta-glucosidase/beta-galactosidase [Carbohydrate transport and metabolism];


The actual alignment was detected with superfamily member COG2723:

Pssm-ID: 442035  Cd Length: 445  Bit Score: 147.54  E-value: 4.73e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190360571   2 AFPAGFGWAAATAAYQVEGGWDADGKGPCVWDTFTHQGGeRVFKNQTGDVACGSYTLWEEDLKCIKQLGLTHYRFSLSWS 81
Cdd:COG2723    4 RFPKDFLWGAATAAYQIEGAWNEDGKGPSIWDTFSRTPG-KVVNGDTGDVACDHYHRYKEDIALMAELGLKAYRFSIAWP 82

                         90
                 ....*....|....*..
gi 190360571  82 RLLPDGtTGFINQKAIQ 98
Cdd:COG2723   83 RIFPDG-EGEVNEAGLD 98
Glyco_hydro super family cl23725
Glycosyl hydrolases; A functionally diverse superfamily containing glycosyl hydrolase families ...
 92-157 4.47e-20

Glycosyl hydrolases; A functionally diverse superfamily containing glycosyl hydrolase families 1,5,10,17,44,72, and others.


The actual alignment was detected with superfamily member pfam00232:

Pssm-ID: 474034 [Multi-domain]  Cd Length: 453  Bit Score: 85.45  E-value: 4.47e-20
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 190360571   92 INQ--KAIQlDKVNLQVYCAWSLLDNFEWNQGYSSRFGLFHVDFeDPARPRVPYTSAKEYAKIIRNNG 157
Cdd:pfam00232 387 LNQvlKAID-DGVDVRGYFAWSLMDNFEWANGYSKRFGLVHVDR-FETQERTPKKSAYWYKEVIENNG 452
 
Name Accession Description Interval E-value
BglB COG2723
Beta-glucosidase/6-phospho-beta-glucosidase/beta-galactosidase [Carbohydrate transport and ...
 2-98 4.73e-43

Beta-glucosidase/6-phospho-beta-glucosidase/beta-galactosidase [Carbohydrate transport and metabolism];


Pssm-ID: 442035  Cd Length: 445  Bit Score: 147.54  E-value: 4.73e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190360571   2 AFPAGFGWAAATAAYQVEGGWDADGKGPCVWDTFTHQGGeRVFKNQTGDVACGSYTLWEEDLKCIKQLGLTHYRFSLSWS 81
Cdd:COG2723    4 RFPKDFLWGAATAAYQIEGAWNEDGKGPSIWDTFSRTPG-KVVNGDTGDVACDHYHRYKEDIALMAELGLKAYRFSIAWP 82

                         90
                 ....*....|....*..
gi 190360571  82 RLLPDGtTGFINQKAIQ 98
Cdd:COG2723   83 RIFPDG-EGEVNEAGLD 98
Glyco_hydro_1 pfam00232
Glycosyl hydrolase family 1;
3-97 9.00e-40

Glycosyl hydrolase family 1;


Pssm-ID: 395176 [Multi-domain]  Cd Length: 453  Bit Score: 139.38  E-value: 9.00e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190360571    3 FPAGFGWAAATAAYQVEGGWDADGKGPCVWDTFTHQGGeRVFKNQTGDVACGSYTLWEEDLKCIKQLGLTHYRFSLSWSR 82
Cdd:pfam00232   5 FPEDFLWGTATAAYQIEGAWNEDGKGPSIWDTFCHTPG-KVFGGDNGDVACDSYHRYKEDVALLKELGVKAYRFSISWPR 83

                          90
                  ....*....|....*
gi 190360571   83 LLPDGtTGFINQKAI 97
Cdd:pfam00232  84 IFPKG-EGEINEAGL 97
PLN02998 PLN02998
beta-glucosidase
 3-98 2.54e-25

beta-glucosidase


Pssm-ID: 215539  Cd Length: 497  Bit Score: 100.56  E-value: 2.54e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190360571   3 FPAGFGWAAATAAYQVEGGWDADGKGPCVWDTFTHQGGERVfknQTGDVACGSYTLWEEDLKCIKQLGLTHYRFSLSWSR 82
Cdd:PLN02998  31 FPPGFVFGSGTSAYQVEGAADEDGRTPSIWDVFAHAGHSGV---AAGNVACDQYHKYKEDVKLMADMGLEAYRFSISWSR 107

                         90
                 ....*....|....*.
gi 190360571  83 LLPDGtTGFINQKAIQ 98
Cdd:PLN02998 108 LLPSG-RGPINPKGLQ 122
Glyco_hydro_1 pfam00232
Glycosyl hydrolase family 1;
92-157 4.47e-20

Glycosyl hydrolase family 1;


Pssm-ID: 395176 [Multi-domain]  Cd Length: 453  Bit Score: 85.45  E-value: 4.47e-20
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 190360571   92 INQ--KAIQlDKVNLQVYCAWSLLDNFEWNQGYSSRFGLFHVDFeDPARPRVPYTSAKEYAKIIRNNG 157
Cdd:pfam00232 387 LNQvlKAID-DGVDVRGYFAWSLMDNFEWANGYSKRFGLVHVDR-FETQERTPKKSAYWYKEVIENNG 452
BglB COG2723
Beta-glucosidase/6-phospho-beta-glucosidase/beta-galactosidase [Carbohydrate transport and ...
 94-154 1.88e-15

Beta-glucosidase/6-phospho-beta-glucosidase/beta-galactosidase [Carbohydrate transport and metabolism];


Pssm-ID: 442035  Cd Length: 445  Bit Score: 72.43  E-value: 1.88e-15
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 190360571  94 QKAIQlDKVNLQVYCAWSLLDNFEWNQGYSSRFGLFHVDFEDPArpRVPYTSAKEYAKIIR 154
Cdd:COG2723  388 HRAIE-DGVDVRGYFVWSLIDNFEWANGYSKRFGLVYVDYDTQK--RTPKKSFYWYKEVIA 445
BGL TIGR03356
beta-galactosidase;
94-149 5.08e-14

beta-galactosidase;


Pssm-ID: 274539  Cd Length: 426  Bit Score: 68.41  E-value: 5.08e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 190360571   94 QKAIQlDKVNLQVYCAWSLLDNFEWNQGYSSRFGLFHVDFEdpARPRVPYTSAKEY 149
Cdd:TIGR03356 374 HRAIE-EGVDVRGYFVWSLLDNFEWAEGYSKRFGLVHVDYE--TQKRTPKDSALWY 426
PRK13511 PRK13511
6-phospho-beta-galactosidase; Provisional
 95-152 7.50e-11

6-phospho-beta-galactosidase; Provisional


Pssm-ID: 184102 [Multi-domain]  Cd Length: 469  Bit Score: 59.24  E-value: 7.50e-11
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 190360571  95 KAIQlDKVNLQVYCAWSLLDNFEWNQGYSSRFGLFHVDFEdpARPRVPYTSAKEYAKI 152
Cdd:PRK13511 408 DAIS-DGANVKGYFIWSLMDVFSWSNGYEKRYGLFYVDFE--TQERYPKKSAYWYKKL 462
 
Name Accession Description Interval E-value
BglB COG2723
Beta-glucosidase/6-phospho-beta-glucosidase/beta-galactosidase [Carbohydrate transport and ...
 2-98 4.73e-43

Beta-glucosidase/6-phospho-beta-glucosidase/beta-galactosidase [Carbohydrate transport and metabolism];


Pssm-ID: 442035  Cd Length: 445  Bit Score: 147.54  E-value: 4.73e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190360571   2 AFPAGFGWAAATAAYQVEGGWDADGKGPCVWDTFTHQGGeRVFKNQTGDVACGSYTLWEEDLKCIKQLGLTHYRFSLSWS 81
Cdd:COG2723    4 RFPKDFLWGAATAAYQIEGAWNEDGKGPSIWDTFSRTPG-KVVNGDTGDVACDHYHRYKEDIALMAELGLKAYRFSIAWP 82

                         90
                 ....*....|....*..
gi 190360571  82 RLLPDGtTGFINQKAIQ 98
Cdd:COG2723   83 RIFPDG-EGEVNEAGLD 98
Glyco_hydro_1 pfam00232
Glycosyl hydrolase family 1;
3-97 9.00e-40

Glycosyl hydrolase family 1;


Pssm-ID: 395176 [Multi-domain]  Cd Length: 453  Bit Score: 139.38  E-value: 9.00e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190360571    3 FPAGFGWAAATAAYQVEGGWDADGKGPCVWDTFTHQGGeRVFKNQTGDVACGSYTLWEEDLKCIKQLGLTHYRFSLSWSR 82
Cdd:pfam00232   5 FPEDFLWGTATAAYQIEGAWNEDGKGPSIWDTFCHTPG-KVFGGDNGDVACDSYHRYKEDVALLKELGVKAYRFSISWPR 83

                          90
                  ....*....|....*
gi 190360571   83 LLPDGtTGFINQKAI 97
Cdd:pfam00232  84 IFPKG-EGEINEAGL 97
PLN02998 PLN02998
beta-glucosidase
 3-98 2.54e-25

beta-glucosidase


Pssm-ID: 215539  Cd Length: 497  Bit Score: 100.56  E-value: 2.54e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190360571   3 FPAGFGWAAATAAYQVEGGWDADGKGPCVWDTFTHQGGERVfknQTGDVACGSYTLWEEDLKCIKQLGLTHYRFSLSWSR 82
Cdd:PLN02998  31 FPPGFVFGSGTSAYQVEGAADEDGRTPSIWDVFAHAGHSGV---AAGNVACDQYHKYKEDVKLMADMGLEAYRFSISWSR 107

                         90
                 ....*....|....*.
gi 190360571  83 LLPDGtTGFINQKAIQ 98
Cdd:PLN02998 108 LLPSG-RGPINPKGLQ 122
PLN02814 PLN02814
beta-glucosidase
 3-97 3.49e-25

beta-glucosidase


Pssm-ID: 215435  Cd Length: 504  Bit Score: 100.02  E-value: 3.49e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190360571   3 FPAGFGWAAATAAYQVEGGWDADGKGPCVWDTFTHqggerVFKNQTGDVACGSYTLWEEDLKCIKQLGLTHYRFSLSWSR 82
Cdd:PLN02814  28 FPEDFLFGAATSAYQWEGAVDEDGRTPSVWDTTSH-----CYNGGNGDIASDGYHKYKEDVKLMAEMGLESFRFSISWSR 102

                         90
                 ....*....|....*
gi 190360571  83 LLPDGtTGFINQKAI 97
Cdd:PLN02814 103 LIPNG-RGLINPKGL 116
PLN02849 PLN02849
beta-glucosidase
 3-105 2.25e-24

beta-glucosidase


Pssm-ID: 215455  Cd Length: 503  Bit Score: 97.73  E-value: 2.25e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190360571   3 FPAGFGWAAATAAYQVEGGWDADGKGPCVWDTFTHQGgervfKNQTGDVACGSYTLWEEDLKCIKQLGLTHYRFSLSWSR 82
Cdd:PLN02849  30 FPEGFVFGAGTSAYQWEGAFDEDGRKPSVWDTFLHSR-----NMSNGDIACDGYHKYKEDVKLMVETGLDAFRFSISWSR 104

                         90       100
                 ....*....|....*....|...
gi 190360571  83 LLPDGtTGFINQKAIQLDKVNLQ 105
Cdd:PLN02849 105 LIPNG-RGSVNPKGLQFYKNFIQ 126
PRK13511 PRK13511
6-phospho-beta-galactosidase; Provisional
 2-97 2.74e-22

6-phospho-beta-galactosidase; Provisional


Pssm-ID: 184102 [Multi-domain]  Cd Length: 469  Bit Score: 91.98  E-value: 2.74e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190360571   2 AFPAGFGWAAATAAYQVEGGWDADGKGPCVWDTFTHQGGervfkNQTGDVACGSYTLWEEDLKCIKQLGLTHYRFSLSWS 81
Cdd:PRK13511   4 TLPKDFIFGGATAAYQAEGATKTDGKGPVAWDKYLEENY-----WFTPDPASDFYHRYPEDLKLAEEFGVNGIRISIAWS 78

                         90
                 ....*....|....*.
gi 190360571  82 RLLPDGtTGFINQKAI 97
Cdd:PRK13511  79 RIFPDG-YGEVNPKGV 93
Glyco_hydro_1 pfam00232
Glycosyl hydrolase family 1;
92-157 4.47e-20

Glycosyl hydrolase family 1;


Pssm-ID: 395176 [Multi-domain]  Cd Length: 453  Bit Score: 85.45  E-value: 4.47e-20
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 190360571   92 INQ--KAIQlDKVNLQVYCAWSLLDNFEWNQGYSSRFGLFHVDFeDPARPRVPYTSAKEYAKIIRNNG 157
Cdd:pfam00232 387 LNQvlKAID-DGVDVRGYFAWSLMDNFEWANGYSKRFGLVHVDR-FETQERTPKKSAYWYKEVIENNG 452
BglB COG2723
Beta-glucosidase/6-phospho-beta-glucosidase/beta-galactosidase [Carbohydrate transport and ...
 94-154 1.88e-15

Beta-glucosidase/6-phospho-beta-glucosidase/beta-galactosidase [Carbohydrate transport and metabolism];


Pssm-ID: 442035  Cd Length: 445  Bit Score: 72.43  E-value: 1.88e-15
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 190360571  94 QKAIQlDKVNLQVYCAWSLLDNFEWNQGYSSRFGLFHVDFEDPArpRVPYTSAKEYAKIIR 154
Cdd:COG2723  388 HRAIE-DGVDVRGYFVWSLIDNFEWANGYSKRFGLVYVDYDTQK--RTPKKSFYWYKEVIA 445
PRK15014 PRK15014
6-phospho-beta-glucosidase BglA; Provisional
 1-99 5.21e-15

6-phospho-beta-glucosidase BglA; Provisional


Pssm-ID: 184975  Cd Length: 477  Bit Score: 71.20  E-value: 5.21e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190360571   1 MAFPAGFGWAAATAAYQVEGGWDADGKGPCVWDTFThQGGERVFKNQTGDVACGSY----------TLWEEDLKCIKQLG 70
Cdd:PRK15014   4 LTLPKDFLWGGAVAAHQVEGGWNKGGKGPSICDVLT-GGAHGVPREITKEVVPGKYypnheavdfyGHYKEDIKLFAEMG 82

                         90       100
                 ....*....|....*....|....*....
gi 190360571  71 LTHYRFSLSWSRLLPDGTTGFINQKAIQL 99
Cdd:PRK15014  83 FKCFRTSIAWTRIFPKGDEAQPNEEGLKF 111
BGL TIGR03356
beta-galactosidase;
94-149 5.08e-14

beta-galactosidase;


Pssm-ID: 274539  Cd Length: 426  Bit Score: 68.41  E-value: 5.08e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 190360571   94 QKAIQlDKVNLQVYCAWSLLDNFEWNQGYSSRFGLFHVDFEdpARPRVPYTSAKEY 149
Cdd:TIGR03356 374 HRAIE-EGVDVRGYFVWSLLDNFEWAEGYSKRFGLVHVDYE--TQKRTPKDSALWY 426
celA PRK09589
6-phospho-beta-glucosidase; Reviewed
 1-98 3.77e-13

6-phospho-beta-glucosidase; Reviewed


Pssm-ID: 181973  Cd Length: 476  Bit Score: 65.98  E-value: 3.77e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190360571   1 MAFPAGFGWAAATAAYQVEGGWDADGKGPCVWDTFThQGGERVFKNQTGDVACGS----------YTLWEEDLKCIKQLG 70
Cdd:PRK09589   2 SGFKKGFLWGGAVAAHQLEGGWNEGGKGISVADVMT-AGAHGVPREITEGVIEGKnypnheaidfYHRYKEDIALFAEMG 80

                         90       100
                 ....*....|....*....|....*...
gi 190360571  71 LTHYRFSLSWSRLLPDGTTGFINQKAIQ 98
Cdd:PRK09589  81 FKCFRTSIAWTRIFPQGDELEPNEEGLQ 108
arb PRK09593
6-phospho-beta-glucosidase; Reviewed
 1-99 8.55e-13

6-phospho-beta-glucosidase; Reviewed


Pssm-ID: 236580  Cd Length: 478  Bit Score: 64.89  E-value: 8.55e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190360571   1 MAFPAGFGWAAATAAYQVEGGWDADGKGPCVWDTFTHqgGERVFKNQTGDV---------------ACGSYTLWEEDLKC 65
Cdd:PRK09593   4 MPFPKGFLWGGATAANQCEGAYNVDGRGLANVDVVPI--GEDRFPIITGEKkmfdfeegyfypakeAIDMYHHYKEDIAL 81

                         90       100       110
                 ....*....|....*....|....*....|....
gi 190360571  66 IKQLGLTHYRFSLSWSRLLPDGTTGFINQKAIQL 99
Cdd:PRK09593  82 FAEMGFKTYRMSIAWTRIFPKGDELEPNEAGLQF 115
PRK09852 PRK09852
cryptic 6-phospho-beta-glucosidase; Provisional
 3-97 3.57e-11

cryptic 6-phospho-beta-glucosidase; Provisional


Pssm-ID: 182112  Cd Length: 474  Bit Score: 60.23  E-value: 3.57e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190360571   3 FPAGFGWAAATAAYQVEGGWDADGKGPCVWDTFTHQ--------GGERVFKNQTGDV-----ACGSYTLWEEDLKCIKQL 69
Cdd:PRK09852   4 FPEGFLWGGALAANQSEGAFREGGKGLTTVDMIPHGehrmavklGLEKRFQLRDDEFypsheAIDFYHRYKEDIALMAEM 83

                         90       100
                 ....*....|....*....|....*...
gi 190360571  70 GLTHYRFSLSWSRLLPDGTTGFINQKAI 97
Cdd:PRK09852  84 GFKVFRTSIAWSRLFPQGDELTPNQQGI 111
PRK13511 PRK13511
6-phospho-beta-galactosidase; Provisional
 95-152 7.50e-11

6-phospho-beta-galactosidase; Provisional


Pssm-ID: 184102 [Multi-domain]  Cd Length: 469  Bit Score: 59.24  E-value: 7.50e-11
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 190360571  95 KAIQlDKVNLQVYCAWSLLDNFEWNQGYSSRFGLFHVDFEdpARPRVPYTSAKEYAKI 152
Cdd:PRK13511 408 DAIS-DGANVKGYFIWSLMDVFSWSNGYEKRYGLFYVDFE--TQERYPKKSAYWYKKL 462
PLN02814 PLN02814
beta-glucosidase
 107-150 2.10e-08

beta-glucosidase


Pssm-ID: 215435  Cd Length: 504  Bit Score: 52.25  E-value: 2.10e-08
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 190360571 107 YCAWSLLDNFEWNQGYSSRFGLFHVDFEDPARPRVPYTSAKEYA 150
Cdd:PLN02814 434 YFVWSMIDLYELLGGYTTSFGMYYVNFSDPGRKRSPKLSASWYT 477
PLN02849 PLN02849
beta-glucosidase
 107-156 9.32e-08

beta-glucosidase


Pssm-ID: 215455  Cd Length: 503  Bit Score: 50.35  E-value: 9.32e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 190360571 107 YCAWSLLDNFEWNQGYSSRFGLFHVDFEDPARPRVPYTSAKEYAKIIRNN 156
Cdd:PLN02849 434 YFVWSFMDLYELLKGYEFSFGLYSVNFSDPHRKRSPKLSAHWYSAFLKGN 483
PLN02998 PLN02998
beta-glucosidase
 103-154 9.59e-08

beta-glucosidase


Pssm-ID: 215539  Cd Length: 497  Bit Score: 50.10  E-value: 9.59e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 190360571 103 NLQVYCAWSLLDNFEWNQGYSSRFGLFHVDFEDPARPRVPYTSAKEYAKIIR 154
Cdd:PLN02998 435 DVKGYFQWSLMDVFELFGGYERSFGLLYVDFKDPSLKRSPKLSAHWYSSFLK 486
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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