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Conserved domains on  [gi|186515493|ref|NP_001119094|]
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TPX2 (targeting protein for Xklp2) protein family [Arabidopsis thaliana]

Protein Classification

WVD2 family protein( domain architecture ID 10536413)

WVD2 (WAVE-DAMPENED 2) family protein similar to Arabidopsis thaliana WVD2 that is a novel microtubule-associated protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TPX2 pfam06886
Targeting protein for Xklp2 (TPX2) domain; This family represents a conserved region ...
 207-286 1.40e-23

Targeting protein for Xklp2 (TPX2) domain; This family represents a conserved region approximately 60 residues long within the eukaryotic targeting protein for Xklp2 (TPX2). Xklp2 is a kinesin-like protein localized on centrosomes throughout the cell cycle and on spindle pole microtubules during metaphase. In Xenopus, it has been shown that Xklp2 protein is required for centrosome separation and maintenance of spindle bi-polarity. TPX2 is a microtubule-associated protein that mediates the binding of the C-terminal domain of Xklp2 to microtubules. It is phosphorylated during mitosis in a microtubule-dependent way. The TPX domain appears to be truncated in fungal species.


:

Pssm-ID: 462029 [Multi-domain]  Cd Length: 77  Bit Score: 93.41  E-value: 1.40e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186515493  207 FSFKCDQRAEKRKEFYVKLEEKTHAKEEEINSMQAKSKETQEAELRMLRKSLNFKATPMPSFYQEPQPPKtelKKIPPTR 286
Cdd:pfam06886   1 FKLHTDERAEERKEFDKKLEEKEQAKEAEKEERERKRKEEEEEEIKQLRKELVFKAQPMPHFYRVFIPPS---KKPPLTR 77
 
Name Accession Description Interval E-value
TPX2 pfam06886
Targeting protein for Xklp2 (TPX2) domain; This family represents a conserved region ...
 207-286 1.40e-23

Targeting protein for Xklp2 (TPX2) domain; This family represents a conserved region approximately 60 residues long within the eukaryotic targeting protein for Xklp2 (TPX2). Xklp2 is a kinesin-like protein localized on centrosomes throughout the cell cycle and on spindle pole microtubules during metaphase. In Xenopus, it has been shown that Xklp2 protein is required for centrosome separation and maintenance of spindle bi-polarity. TPX2 is a microtubule-associated protein that mediates the binding of the C-terminal domain of Xklp2 to microtubules. It is phosphorylated during mitosis in a microtubule-dependent way. The TPX domain appears to be truncated in fungal species.


Pssm-ID: 462029 [Multi-domain]  Cd Length: 77  Bit Score: 93.41  E-value: 1.40e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186515493  207 FSFKCDQRAEKRKEFYVKLEEKTHAKEEEINSMQAKSKETQEAELRMLRKSLNFKATPMPSFYQEPQPPKtelKKIPPTR 286
Cdd:pfam06886   1 FKLHTDERAEERKEFDKKLEEKEQAKEAEKEERERKRKEEEEEEIKQLRKELVFKAQPMPHFYRVFIPPS---KKPPLTR 77
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 164-310 6.89e-03

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 38.90  E-value: 6.89e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186515493 164 EKVKPKSQKKQAHETSEDDTQSSNSPKAddgkPRKVGALPNY-GFSFKCDQRAEKRKEFYVKLEEKT--HAKEEEINSMQ 240
Cdd:PTZ00449 486 KKLIKKSKKKLAPIEEEDSDKHDEPPEG----PEASGLPPKApGDKEGEEGEHEDSKESDEPKEGGKpgETKEGEVGKKP 561

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 186515493 241 AKSKETQEAELRMLRKSLNF-KATPMPSFYQEPQPPKTELKKIPPTRPKSPKLGR--KKTASGADSEETQTPR 310
Cdd:PTZ00449 562 GPAKEHKPSKIPTLSKKPEFpKDPKHPKDPEEPKKPKRPRSAQRPTRPKSPKLPEllDIPKSPKRPESPKSPK 634
 
Name Accession Description Interval E-value
TPX2 pfam06886
Targeting protein for Xklp2 (TPX2) domain; This family represents a conserved region ...
 207-286 1.40e-23

Targeting protein for Xklp2 (TPX2) domain; This family represents a conserved region approximately 60 residues long within the eukaryotic targeting protein for Xklp2 (TPX2). Xklp2 is a kinesin-like protein localized on centrosomes throughout the cell cycle and on spindle pole microtubules during metaphase. In Xenopus, it has been shown that Xklp2 protein is required for centrosome separation and maintenance of spindle bi-polarity. TPX2 is a microtubule-associated protein that mediates the binding of the C-terminal domain of Xklp2 to microtubules. It is phosphorylated during mitosis in a microtubule-dependent way. The TPX domain appears to be truncated in fungal species.


Pssm-ID: 462029 [Multi-domain]  Cd Length: 77  Bit Score: 93.41  E-value: 1.40e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186515493  207 FSFKCDQRAEKRKEFYVKLEEKTHAKEEEINSMQAKSKETQEAELRMLRKSLNFKATPMPSFYQEPQPPKtelKKIPPTR 286
Cdd:pfam06886   1 FKLHTDERAEERKEFDKKLEEKEQAKEAEKEERERKRKEEEEEEIKQLRKELVFKAQPMPHFYRVFIPPS---KKPPLTR 77
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 164-310 6.89e-03

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 38.90  E-value: 6.89e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186515493 164 EKVKPKSQKKQAHETSEDDTQSSNSPKAddgkPRKVGALPNY-GFSFKCDQRAEKRKEFYVKLEEKT--HAKEEEINSMQ 240
Cdd:PTZ00449 486 KKLIKKSKKKLAPIEEEDSDKHDEPPEG----PEASGLPPKApGDKEGEEGEHEDSKESDEPKEGGKpgETKEGEVGKKP 561

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 186515493 241 AKSKETQEAELRMLRKSLNF-KATPMPSFYQEPQPPKTELKKIPPTRPKSPKLGR--KKTASGADSEETQTPR 310
Cdd:PTZ00449 562 GPAKEHKPSKIPTLSKKPEFpKDPKHPKDPEEPKKPKRPRSAQRPTRPKSPKLPEllDIPKSPKRPESPKSPK 634
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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