|
Name |
Accession |
Description |
Interval |
E-value |
| PLN03237 |
PLN03237 |
DNA topoisomerase 2; Provisional |
1-1424 |
0e+00 |
|
DNA topoisomerase 2; Provisional
Pssm-ID: 215641 [Multi-domain] Cd Length: 1465 Bit Score: 2490.49 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 1 MATKLPLQNSNAANVAKAPaksRAAAGGKTIEEMYQKKSQLEHILLRPDTYIGSIEKHTQTLWVYEKDEMVQRPVTYVPG 80
Cdd:PLN03237 1 MAEKLPLQESNSANVAAAP---AASSGGKTIEEMYQKKSQLEHILLRPDTYIGSIEKHTQTLWVYETDKMVQRSVTYVPG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 81 LYKIFDEILVNAADNKQRDAKMDSVQVVIDVEQNLISVCNSGAGVPVEIHQEEGIYVPEMIFGHLLTSSNYDDNVKKTTG 160
Cdd:PLN03237 78 LYKIFDEILVNAADNKQRDPKMDSLRVVIDVEQNLISVYNNGDGVPVEIHQEEGVYVPEMIFGHLLTSSNYDDNEKKTTG 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 161 GRNGYGAKLTNIFSTEFIIETADGKRLKKYKQVFENNMGKKSEPVITKCNKSENWTKVTFKPDLKKFNMTELEDDVVALM 240
Cdd:PLN03237 158 GRNGYGAKLTNIFSTEFVIETADGKRQKKYKQVFSNNMGKKSEPVITKCKKSENWTKVTFKPDLAKFNMTHLEDDVVALM 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 241 SKRVFDIAGCLGKSVKVELNGKQIPVKSFTDYVDLYLSAANKSRTEdPLPRLTEKVNDRWEVCVSLSEGQFQQVSFVNSI 320
Cdd:PLN03237 238 KKRVVDIAGCLGKTVKVELNGKRIPVKSFSDYVDLYLESANKSRPE-NLPRIYEKVNDRWEVCVSLSEGQFQQVSFVNSI 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 321 ATIKGGTHVDYVTSQITNHIVAAVNKKNKNANVKAHNVKNHLWVFVNALIDNPAFDSQTKETLTLRQSSFGSKCELSEDF 400
Cdd:PLN03237 317 ATIKGGTHVDYVTNQIANHVMEAVNKKNKNANIKAHNVKNHLWVFVNALIDNPAFDSQTKETLTLRQSSFGSKCELSEDF 396
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 401 LKKVGKSGVVENLLSWADFKQNKDLKKSDGAKTGRVL-VEKLDDAAEAGGKNSRLCTLILTEGDSAKSLALAGRSVLGNN 479
Cdd:PLN03237 397 LKKVMKSGIVENLLSWADFKQSKELKKTDGAKTTRVTgIPKLEDANEAGGKNSEKCTLILTEGDSAKALAVAGLSVVGRN 476
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 480 YCGVFPLRGKLLNVREASTTQITNNKEIENLKKILGLKQNMKYENVNSLRYGQMMIMTDQDHDGSHIKGLLINFIHSFWP 559
Cdd:PLN03237 477 YYGVFPLRGKLLNVREASHKQIMNNAEIENIKQILGLQHGKQYESVKSLRYGHLMIMTDQDHDGSHIKGLLINFIHSFWP 556
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 560 SLLQVPSFLVEFITPIVKATRKGtKKVLSFYSMPEYEEWKESLKGNATGWDIKYYKGLGTSTAEEGKEYFSNLGLHKKDF 639
Cdd:PLN03237 557 SLLKVPSFLVEFITPIVKATRRG-KKVLSFYSMPEYEEWKESLGGNATGWSIKYYKGLGTSTAKEGKEYFKNLGKHKKDF 635
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 640 VWEDEQDGEAIELAFSKKKIEARKNWLSSYVPGNHLDQRQPKVTYSDFVNKELILFSMADLQRSIPSMVDGLKPGQRKIL 719
Cdd:PLN03237 636 VWEDEQDGDAIELAFSKKKIEARKNWLRQYEPGTHLDQTQKDVKYSDFVNKELILFSMADLQRSIPSMVDGLKPGQRKIL 715
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 720 FVAFKKIARKEMKVAQLVGYVSLLSAYHHGEQSLASAIIGMAQDYVGSNNINLLLPNGQFGTRTSGGKDSASARYIFTKL 799
Cdd:PLN03237 716 FCSFKRNFVKEAKVAQLSGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLLLPNGQFGTRLQGGKDHASARYIFTRL 795
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 800 SPVTRILFPKDDDLLLDYLNEDGQRIEPTWYMPIIPTVLVNGAEGIGTGWSTFIPNYNPREIVANVRRLLNGESMVPMDP 879
Cdd:PLN03237 796 SPITRFLFPKDDDILLDYLNEDGQSIEPTWYMPIIPTVLVNGAEGIGTGWSTFIPNYNPRDIVANIRRLLNGESMEPMHP 875
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 880 WYRGFKGTIEKTASKEGGCTYTITGLYEEVDETTIRITELPIRRWNDDYKNFLQSLKTDN---GAPFFQDVKAYNDEKSV 956
Cdd:PLN03237 876 WYRGFKGTIEKTASKEGGCTYTITGLYEEVDETTLRITELPIRRWTDDYKEFLESLKTDNnknKDPFIKDVKAYNDDTTV 955
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 957 DFDLILSEENMLAARQEGFLKKFKLTTTIATSNMHLFDKKGVIKKYVTPEQILEEFFDLRFEYYEKRKETVVKNMEIELL 1036
Cdd:PLN03237 956 HFEVILSEENMLAAKQEGLLKKFKLTTTISTSNMHLFDSKGVIKKYDTPEQILEEFFHLRLEYYEKRKEVLLKNLEFELL 1035
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 1037 KLENKARFILAVLSGEIIVNKRKKADIVEDLRQKGFTPFPRKAESVEAAIAGAVdDDAAEEPEEILVdpeSSSSYIPGSE 1116
Cdd:PLN03237 1036 KLENKVRFILAVVDGEIIVNNRKKADLVEELRQKGFTPFPKKAKSVEAAVAGAT-DDAAEEEEEIDV---SSSSGVRGSD 1111
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 1117 YDYLLAMAIASLTIEKVEELLADRDKMIIAVADMKKTTPKSLWLSDLESLDKELEKLDLKDAQVQQAIEAAQK-KIRAKS 1195
Cdd:PLN03237 1112 YDYLLSMAIGTLTLEKVQELCADRDKLNIEVEDLKKTTPKSLWLKDLDALEKELDKLDKEDAKAEEAREKLQRaAARGES 1191
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 1196 GAAVKVKRQAPKKPAPKKTTKKASESETTEASY--SAMDTDnNVAEVVKPKGRQGAKKKAPAAAKEV-EEDEMLDLAQRL 1272
Cdd:PLN03237 1192 GAAKKVSRQAPKKPAPKKTTKKASESETTEETYgsSAMETE-NVAEVVKPKGRAGAKKKAPAAAKEKeEEDEILDLKDRL 1270
|
1290 1300 1310 1320 1330 1340 1350 1360
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 1273 AQYNFGSAPADSSKTAETSKAIAVDDDDDDVVV-------------------EVAPV----KKGGRKPAATKAAKPP--A 1327
Cdd:PLN03237 1271 AAYNLDSAPAQSAKMEETVKAVPARRAAARKKPlasvsvisdsddddddfavEVSLAerlkKKGGRKPAAANKKAAKppA 1350
|
1370 1380 1390 1400 1410 1420 1430 1440
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 1328 APRKRGKQTVAS-----TEVL----AIGVSPEKKVRKMRSSPFNKKSSSVMSRLADNKEEESSENVAGNSSSEKSGGDVS 1398
Cdd:PLN03237 1351 AAKKRGPATVQSgqkllTEMLkpaeAIGISPEKKVRKMRASPFNKKSGSVLGRAATNKETESSENVSGSSSSEKDEIDVS 1430
|
1450 1460
....*....|....*....|....*.
gi 186510360 1399 AISRPQRANRRKMTYVLSDSESESAN 1424
Cdd:PLN03237 1431 AKPRPQRANRKQTTYVLSDSESESAD 1456
|
|
| PLN03128 |
PLN03128 |
DNA topoisomerase 2; Provisional |
29-1171 |
0e+00 |
|
DNA topoisomerase 2; Provisional
Pssm-ID: 215593 [Multi-domain] Cd Length: 1135 Bit Score: 1902.52 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 29 KTIEEMYQKKSQLEHILLRPDTYIGSIEKHTQTLWVYEKDEMVQRPVTYVPGLYKIFDEILVNAADNKQRDAKMDSVQVV 108
Cdd:PLN03128 1 KTIEETYQKKTQLEHILLRPDTYIGSTEKHTQTLWVYEGGEMVNREVTYVPGLYKIFDEILVNAADNKQRDPSMDSLKVD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 109 IDVEQNLISVCNSGAGVPVEIHQEEGIYVPEMIFGHLLTSSNYDDNVKKTTGGRNGYGAKLTNIFSTEFIIETADGKRLK 188
Cdd:PLN03128 81 IDVEQNTISVYNNGKGIPVEIHKEEGVYVPELIFGHLLTSSNFDDNEKKTTGGRNGYGAKLANIFSTEFTVETADGNRGK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 189 KYKQVFENNMGKKSEPVITKCNKSENWTKVTFKPDLKKFNMTELEDDVVALMSKRVFDIAGCLGKSVKVELNGKQIPVKS 268
Cdd:PLN03128 161 KYKQVFTNNMSVKSEPKITSCKASENWTKITFKPDLAKFNMTRLDEDVVALMSKRVYDIAGCLGKKLKVELNGKKLPVKS 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 269 FTDYVDLYLSAANKsrtEDPLPRLTEKVNDRWEVCVSLSEGQFQQVSFVNSIATIKGGTHVDYVTSQITNHIVAAVNKKN 348
Cdd:PLN03128 241 FQDYVGLYLGPNSR---EDPLPRIYEKVNDRWEVCVSLSDGSFQQVSFVNSIATIKGGTHVDYVADQIVKHIQEKVKKKN 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 349 KNANV-KAHNVKNHLWVFVNALIDNPAFDSQTKETLTLRQSSFGSKCELSEDFLKKVGKSGVVENLLSWADFKQNKDLKK 427
Cdd:PLN03128 318 KNATHvKPFQIKNHLWVFVNCLIENPTFDSQTKETLTTRPSSFGSKCELSEEFLKKVEKCGVVENILSWAQFKQQKELKK 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 428 SDGAKTGRVL-VEKLDDAAEAGGKNSRLCTLILTEGDSAKSLALAGRSVLGNNYCGVFPLRGKLLNVREASTTQITNNKE 506
Cdd:PLN03128 398 KDGAKRQRLTgIPKLDDANDAGGKKSKDCTLILTEGDSAKALAMSGLSVVGRDHYGVFPLRGKLLNVREASHKQIMKNAE 477
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 507 IENLKKILGLKQNMKY--ENVNSLRYGQMMIMTDQDHDGSHIKGLLINFIHSFWPSLLQVPSFLVEFITPIVKATRKgtK 584
Cdd:PLN03128 478 ITNIKQILGLQFGKTYdeENTKSLRYGHLMIMTDQDHDGSHIKGLIINFFHSFWPSLLKIPGFLVEFITPIVKATKG--G 555
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 585 KVLSFYSMPEYEEWKESLKGNATGWDIKYYKGLGTSTAEEGKEYFSNLGLHKKDFVWEDEQDGEAIELAFSKKKIEARKN 664
Cdd:PLN03128 556 KSLSFYTMPEYEAWKESLEGETKGWTIKYYKGLGTSTSEEAKEYFSNLDIHKKEFLWQSDEDGDLIDMAFSKKRVEDRKI 635
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 665 WLSSYVPGNHLDQRQPKVTYSDFVNKELILFSMADLQRSIPSMVDGLKPGQRKILFVAFKKIARKEMKVAQLVGYVSLLS 744
Cdd:PLN03128 636 WLNNYEPGTFLDQTGNGISYSDFINKELILFSQADLARSIPSMVDGLKPSQRKVLFACFKRNLKSEIKVAQLSGYVAEHS 715
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 745 AYHHGEQSLASAIIGMAQDYVGSNNINLLLPNGQFGTRTSGGKDSASARYIFTKLSPVTRILFPKDDDLLLDYLNEDGQR 824
Cdd:PLN03128 716 AYHHGEASLASTIIGMAQDFVGSNNINLLTPSGQFGTRLQGGKDAASARYIFTRLSPITRALFPKDDDVLLNYLNEDGQS 795
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 825 IEPTWYMPIIPTVLVNGAEGIGTGWSTFIPNYNPREIVANVRRLLNGESMVPMDPWYRGFKGTIEKTASKEGGcTYTITG 904
Cdd:PLN03128 796 IEPEWYCPIIPMVLVNGSEGIGTGWSTFIPNYNPRDIIANIRRLLRGEELEPMHPWYRGFKGTITEVSTSRSG-SYTVTG 874
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 905 LYEEVDETTIRITELPIRRWNDDYKNFLQSLK--TDNGAPFFQDVKAYNDEKSVDFDLILSEENMLAARQEGFLKKFKLT 982
Cdd:PLN03128 875 IIEQIGDTTIRITELPVRKWTQDYKEFLEALLtgTKKKEPEIKDFKENHTDTTVHFTVTLSEEKMARALAEGLEKKFKLS 954
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 983 TTIATSNMHLFDKKGVIKKYVTPEQILEEFFDLRFEYYEKRKETVVKNMEIELLKLENKARFILAVLSGEIIVNKRKKAD 1062
Cdd:PLN03128 955 TTISTSNMHLFDKDGKIKKYDSPEDILEEFFHLRLDLYVKRKEVLLENLEYELKKLDNKARFILAVVKGEIVVNNRKRAE 1034
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 1063 IVEDLRQKGFTPFPRKAESVEAaiagavdDDAAEEPEEILVDPESSSSYIPGSeYDYLLAMAIASLTIEKVEELLADRDK 1142
Cdd:PLN03128 1035 LLAELEEKGFDKFPKTAKISET-------NVVGDRDGEASEEEEASDNELAKS-YDYLLGMPISSLTLEKVDELRAERAK 1106
|
1130 1140
....*....|....*....|....*....
gi 186510360 1143 MIIAVADMKKTTPKSLWLSDLESLDKELE 1171
Cdd:PLN03128 1107 KETEVEELKKTTPEDLWRKDLDAFEEALD 1135
|
|
| PTZ00108 |
PTZ00108 |
DNA topoisomerase 2-like protein; Provisional |
28-1422 |
0e+00 |
|
DNA topoisomerase 2-like protein; Provisional
Pssm-ID: 240271 [Multi-domain] Cd Length: 1388 Bit Score: 1697.54 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 28 GKTIEEMYQKKSQLEHILLRPDTYIGSIEKHTQTLWVY--EKDEMVQRPVTYVPGLYKIFDEILVNAADNKQRD---AKM 102
Cdd:PTZ00108 3 NKTVEERYQKKTQIEHILLRPDTYIGSIETQTEDMWVYdeEKNRMVYKTITYVPGLYKIFDEILVNAADNKARDkggHRM 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 103 DSVQVVIDVEQNLISVCNSGAGVPVEIHQEEGIYVPEMIFGHLLTSSNYDDNVKKTTGGRNGYGAKLTNIFSTEFIIETA 182
Cdd:PTZ00108 83 TYIKVTIDEENGEISVYNDGEGIPVQIHKEHKIYVPEMIFGHLLTSSNYDDTEKRVTGGRNGFGAKLTNIFSTKFTVECV 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 183 DGKRLKKYKQVFENNMGKKSEPVITKCNKSENWTKVTFKPDLKKFNMTELEDDVVALMSKRVFDIAGCLGKsVKVELNGK 262
Cdd:PTZ00108 163 DSKSGKKFKMTWTDNMSKKSEPRITSYDGKKDYTKVTFYPDYAKFGMTEFDDDMLRLLKKRVYDLAGCFGK-LKVYLNGE 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 263 QIPVKSFTDYVDLYLSAaNKSRTEDPLPRLTEKVNDRWEVCVSLSEGQFQQVSFVNSIATIKGGTHVDYVTSQITNHIVA 342
Cdd:PTZ00108 242 RIAIKSFKDYVDLYLPD-GEEGKKPPYPFVYTSVNGRWEVVVSLSDGQFQQVSFVNSICTTKGGTHVNYILDQLISKLQE 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 343 AVNKKNKNANV-KAHNVKNHLWVFVNALIDNPAFDSQTKETLTLRQSSFGSKCELSEDFLKKVGKSGVVENLLSWADFKQ 421
Cdd:PTZ00108 321 KAKKKKKKGKEiKPNQIKNHLWVFVNCLIVNPSFDSQTKETLTTKPSKFGSTCELSEKLIKYVLKSPILENIVEWAQAKL 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 422 NKDL-KKSDGAKTGRVL-VEKLDDAAEAGGKNSRLCTLILTEGDSAKSLALAGRSVLGNNYCGVFPLRGKLLNVREASTT 499
Cdd:PTZ00108 401 AAELnKKMKAGKKSRILgIPKLDDANDAGGKNSEECTLILTEGDSAKALALAGLSVVGRDYYGVFPLRGKLLNVRDASLK 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 500 QITNNKEIENLKKILGLKQNMKYENVNSLRYGQMMIMTDQDHDGSHIKGLLINFIHSFWPSLLQVPSFLVEFITPIVKAT 579
Cdd:PTZ00108 481 QLMNNKEIQNLFKILGLDIGKKYEDPKGLRYGSLMIMTDQDHDGSHIKGLLINMIHHFWPSLLKNPGFLKEFITPIVKAT 560
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 580 RKGtKKVLSFYSMPEYEEWKESLkgNATGWDIKYYKGLGTSTAEEGKEYFSNLGLHKKDFVWEDEQDGEAIELAFSKKKI 659
Cdd:PTZ00108 561 KKG-NQVISFFTIPDFEKWKQTV--GLKGWKIKYYKGLGTSTDKEGKEYFSNIDKHRIRFVYVDDSDDDSIDLAFSKKRV 637
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 660 EARKNWLSSYVPGNHLDQRQPKVTYSDFVNKELILFSMADLQRSIPSMVDGLKPGQRKILFVAFKKIARKEMKVAQLVGY 739
Cdd:PTZ00108 638 EDRKEWITNYKGGTYVDHSKKKLTYSDFVNKELILFSIADNERSIPSLVDGLKPGQRKILFACFKRNLKNEIKVAQLSGY 717
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 740 VSLLSAYHHGEQSLASAIIGMAQDYVGSNNINLLLPNGQFGTRTSGGKDSASARYIFTKLSPVTRILFPKDDDLLLDYLN 819
Cdd:PTZ00108 718 VSEHSAYHHGEQSLQQTIVGMAQNFVGSNNINLLYPCGQFGSRLQGGKDHAAARYIFTKLSKITRYIFPEEDDPILDYLE 797
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 820 EDGQRIEPTWYMPIIPTVLVNGAEGIGTGWSTFIPNYNPREIVANVRRLLNGESMVPMDPWYRGFKGTIEKtaSKEGGct 899
Cdd:PTZ00108 798 DDGQSVEPFYYVPIIPMVLVNGAEGIGTGFSTSIPNYNPLDIIDNLRRRLNGEEVRPLVPWYRGFKGTIER--NPKGK-- 873
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 900 YTITGLYEEVDETTIRITELPIRRWNDDYKNFLQSLkTDNGAPFFQDVKAYNDEKSVDFDLILSEENMLAARQEGFLKKF 979
Cdd:PTZ00108 874 FISKGIYEKVPDGTVEITELPIGKWTEDYKEFLESE-TLKEKDVIVDYRDYSTANTVHFTVKLNDGVLEQWEEEGIEKVF 952
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 980 KLTTTIATSNMHLFDKKGVIKKYVTPEQILEEFFDLRFEYYEKRKETVVKNMEIELLKLENKARFILAVLSGEIIVNKRK 1059
Cdd:PTZ00108 953 KLKSTISTTNMVLFDENGKIKKYSDALDILKEFYLVRLDLYKKRKEYLLGKLERELARLSNKVRFIKHVINGELVITNAK 1032
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 1060 KADIVEDLRQKGFTPFPRKAESVEAAIAGAVDDDAAEEPEEILVDPESSSsyIPGSEYDYLLAMAIASLTIEKVEELLAD 1139
Cdd:PTZ00108 1033 KKDLVKELKKLGYVRFKDIIKKKSEKITAEEEEGAEEDDEADDEDDEEEL--GAAVSYDYLLSMPIWSLTKEKVEKLNAE 1110
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 1140 RDKMIIAVADMKKTTPKSLWLSDLESLDKELEKldlkdaQVQQAIEAAQKKIRAKSGAAVKVKRQAPKKPAPKKTTKKAS 1219
Cdd:PTZ00108 1111 LEKKEKELEKLKNTTPKDMWLEDLDKFEEALEE------QEEVEEKEIAKEQRLKSKTKGKASKLRKPKLKKKEKKKKKS 1184
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 1220 ESETTEASYSAMDTDNNVAEVVKPKGRQGAKKKAPAAAKEVEEDEMLDLAQRLAQYNfgsAPADSSKTAETSKAIAVDDD 1299
Cdd:PTZ00108 1185 SADKSKKASVVGNSKRVDSDEKRKLDDKPDNKKSNSSGSDQEDDEEQKTKPKKSSVK---RLKSKKNNSSKSSEDNDEFS 1261
|
1290 1300 1310 1320 1330 1340 1350 1360
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 1300 DDDVVVEVAPVKKGGRKPAATKAAKPPAAPRKRGKQTVASTEvlaigvspekkvrkmrSSPFNKKSSSVMSRLADNKEEE 1379
Cdd:PTZ00108 1262 SDDLSKEGKPKNAPKRVSAVQYSPPPPSKRPDGESNGGSKPS----------------SPTKKKVKKRLEGSLAALKKKK 1325
|
1370 1380 1390 1400
....*....|....*....|....*....|....*....|...
gi 186510360 1380 SSENVAGNSSSEKSGGDVSAISRPQRANRRKMTYVLSDSESES 1422
Cdd:PTZ00108 1326 KSEKKTARKKKSKTRVKQASASQSSRLLRRPRKKKSDSSSEDD 1368
|
|
| TOP2c |
smart00433 |
TopoisomeraseII; Eukaryotic DNA topoisomerase II, GyrB, ParE |
80-671 |
0e+00 |
|
TopoisomeraseII; Eukaryotic DNA topoisomerase II, GyrB, ParE
Pssm-ID: 214659 [Multi-domain] Cd Length: 594 Bit Score: 767.10 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 80 GLYKIFDEILVNAADNKQRDaKMDSVQVVIDVEqNLISVCNSGAGVPVEIHQEEGIYVPEMIFGHLLTSSNYDDNVKKTT 159
Cdd:smart00433 1 GLHHLVDEIVDNAADEALAG-YMDTIKVTIDKD-NSISVEDNGRGIPVEIHPKEKKYAPEVIFTVLHAGGKFDDDAYKVS 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 160 GGRNGYGAKLTNIFSTEFIIETADGKrlKKYKQVFENNMGKKSEPVITKCNKsENWTKVTFKPDLKKFNMTelEDDVVAL 239
Cdd:smart00433 79 GGLHGVGASVVNALSTEFEVEVARDG--KEYKQSFSNNGKPLSEPKIIGDTK-KDGTKVTFKPDLEIFGMT--TDDDFEL 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 240 MSKRVFDIAGCLgKSVKVELNGKQ-------IPVKSFTDYVDLYLSAANKSrTEDPLPRLTEKVNDRWEVCVSLSEG-QF 311
Cdd:smart00433 154 LKRRLRELAFLN-KGVKITLNDERsdeektfLFEGGIKDYVELLNKNKELL-SPEPTYIEGEKDNIRVEVAFQYTDGySE 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 312 QQVSFVNSIATIKGGTHVDYVTSQITNHIVAAVNKKNKNANVK--AHNVKNHLWVFVNALIDNPAFDSQTKETLTLRQSS 389
Cdd:smart00433 232 NIVSFVNNIATTEGGTHENGFKDALTRVINEYAKKKKKLKEKNikGEDVREGLTAFISVKIPEPQFEGQTKEKLGTSEVR 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 390 FG-----SKCELSEDFLKKVGKSGVVENLLSWADFKQN-KDLKKSDG--AKTGRVLVEKLDDAAEAGGKNsrlCTLILTE 461
Cdd:smart00433 312 FGvekivSECLLSFLEENPVEASKIVEKVLLAAKARAAaKKARELTRkkKLSSISLPGKLADASSAGPKK---CELFLVE 388
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 462 GDSAKSLALAGRSvlgNNYCGVFPLRGKLLNVREASTTQITNNKEIENLKKILGLKQNMKYeNVNSLRYGQMMIMTDQDH 541
Cdd:smart00433 389 GDSAGGSAKSGRD---RDFQAILPLRGKILNVEKASLDKILKNEEIQALITALGLGIGKDF-DIEKLRYGKIIIMTDADV 464
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 542 DGSHIKGLLINFIHSFWPSLLQVPsFLVEFITPIVKATRKGTKKVLSFYSMPEYEEWKESLKGNATGWDIKYYKGLGTST 621
Cdd:smart00433 465 DGSHIKGLLLTFFYRYMPPLIEAG-FVYIAIPPLYKVTKGKKKYVYSFYSLDEYEKWLEKTEGNKSKYEIQRYKGLGEMN 543
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|.
gi 186510360 622 AEEGKEYFSNLGLHKKDFVW-EDEQDGEAIELAFSKKKIEARKNWLSSYVP 671
Cdd:smart00433 544 ADQLWETTMDPERRTLLFVTlDDADEADLIFSALMGDKVEPRKEWIEENAP 594
|
|
| TOP4c |
smart00434 |
DNA Topoisomerase IV; Bacterial DNA topoisomerase IV, GyrA, ParC |
682-1161 |
3.78e-168 |
|
DNA Topoisomerase IV; Bacterial DNA topoisomerase IV, GyrA, ParC
Pssm-ID: 214660 [Multi-domain] Cd Length: 444 Bit Score: 510.95 E-value: 3.78e-168
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 682 VTYSDFVNKELILFSM-ADLQRSIPSMVDGLKPGQRKILFVAFKKIARK-EMKVAQLVGYVSLLSAYH-HGEQSLASAII 758
Cdd:smart00434 1 IDIEDFINKEYLDYSMsVINGRAIPDVRDGLKPVQRRILYAMFKRGLTPdEPKVKSARGVGDVMGKYHpHGDSSLYDTIV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 759 GMAQDYVgsNNINLLLPNGQFGTRTsGGKDSASARYIFTKLSPVTRILFPKDDDLLLDYLNE-DGQRIEPTWYMPIIPTV 837
Cdd:smart00434 81 RMAQDFS--NNYPLLDGQGNFGSRL-DGDDAAAMRYTETRLSPLARLLLPDIDKDTVDFVPNyDGQEIEPTVLPPIIPNL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 838 LVNGAEGIGTGWSTFIPNYNPREIVANVRRLLNGESMVP----MDPWYRGFKGTIEKTASKEggctYTITGLYEEVDETT 913
Cdd:smart00434 158 LVNGSSGIAVGMATNIPPHNLREVIDAVRRLIDNPDASIdelmMIPWGPDFPTGGEIVGPGK----YVVRGKIEIEDDNT 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 914 IRITELPIRRWNDDYKNFLQSLKTDNG-APFFQDVKAYNDEKSVDFDLILSEENMLAARQEGFLKKFKLTTTIATSNMHL 992
Cdd:smart00434 234 IVITELPYQVNTADLIEKIAELVKDKKiEGIIDVRDESHDRTGVRIVIELKRGAMAEVVLNGLYKLTKLQTTFSINMLAL 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 993 FDkKGVIKKYVTPEqILEEFFDLRFEYYEKRKETVVKNMEiELLKLENKARFILAVLSGEIIVNKRKKADIVEDLRQKGF 1072
Cdd:smart00434 314 FD-NGRPKKYNLKE-ILKEFLDHRLEVYTRRKEYLLGKLE-AERLHILEGLFIALSIIDEIIVLIRSSKDLAKEAKEKLM 390
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 1073 TPFprkaesveaaiagavdddaaeepeeilvdpessssYIPGSEYDYLLAMAIASLTIEKVEELLADRDKMIIAVADMKK 1152
Cdd:smart00434 391 ERF-----------------------------------ELSEIQADAILDMRLRRLTKLEVEKLEKELKELEKEIEDLEK 435
|
....*....
gi 186510360 1153 TTPKSLWLS 1161
Cdd:smart00434 436 ILASEEWLN 444
|
|
| TOP4c |
cd00187 |
DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), ... |
701-1166 |
2.35e-151 |
|
DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA topology by catalysing the concerted breakage and rejoining of DNA strands during normal cellular growth.
Pssm-ID: 238111 [Multi-domain] Cd Length: 445 Bit Score: 466.66 E-value: 2.35e-151
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 701 QRSIPSMVDGLKPGQRKILFVAFK---KIARKEMKVAQLVGYVSLLSaYHHGEQSLASAIIGMAQDYvgSNNINLLLPNG 777
Cdd:cd00187 2 GRALPDVRDGLKPVQRRILYAMFKrglTPDKPEKKVARLVGDVAGKY-HPHGDSSLYDTIVRMAQDF--SNNIPLLDPQG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 778 QFGTRtsGGKDSASARYIFTKLSPVTRILFPKDDDLLLD-YLNEDGQRIEPTWYMPIIPTVLVNGAEGIGTGWSTFIPNY 856
Cdd:cd00187 79 NFGSR--DGDDAAAMRYTETRLSPIARLLLPDIDDPTVDfVPNYDGQEVEPEVLPPIFPNLLVNGSSGIAVGMATNIPPH 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 857 NPREIVANVRRLLNGESM-------VPMDPWYRGFkGTIEKT-----ASKEGGCTYTITGLYEEVDE---TTIRITELPI 921
Cdd:cd00187 157 NLREVIDALRALIDNPEAsidelmeIIKGPDFPTG-GIIEGRagireAYETGRGRYIIRGKYEIEDDegrNTIEITELPY 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 922 RRWNDDYKNFLQSLKTDNGAPFFQDVKAYNDEKSVDFDLILSEENMLAARQEGFLKKFKLTTTIATsNMHLFDKKGVIKK 1001
Cdd:cd00187 236 QVNKAKLKEKIAELVKDKKIEGISDVRDESDREGIRFVIELKRGAMAEVVLNGLYKVTKLQTTFGI-NMVAFDPNGRPKK 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 1002 YvTPEQILEEFFDLRFEYYEKRKETVVKNMEIELLKLENKARFILAVlsgeIIVNKRK------KADIVEDLRQKGFTPF 1075
Cdd:cd00187 315 L-NLKEILQEFLDHRLEVYTRRKEYELGKAEARLHILEGLLKAILNI----DEVINLIrssdeaKKALIEELEKLGFSEI 389
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 1076 prkaesveaaiagavdddaaeepeeilvdpessssyipgsEYDYLLAMAIASLTIEKVEELLADRDKMIIAVADMKKTT- 1154
Cdd:cd00187 390 ----------------------------------------QADAILDMRLRRLTKLEREKLLKELKELEAEIEDLEKILa 429
|
490
....*....|....*.
gi 186510360 1155 ----PKSLWLSDLESL 1166
Cdd:cd00187 430 seerPKDLWKEELDEF 445
|
|
| DNA_topoisoIV |
pfam00521 |
DNA gyrase/topoisomerase IV, subunit A; |
702-1164 |
2.48e-140 |
|
DNA gyrase/topoisomerase IV, subunit A;
Pssm-ID: 459843 [Multi-domain] Cd Length: 432 Bit Score: 436.98 E-value: 2.48e-140
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 702 RSIPSMVDGLKPGQRKILFVAFK--KIARKEMKVAQLVGYVslLSAYH-HGEQSLASAIIGMAQDYVGsnNINLLLPNGQ 778
Cdd:pfam00521 1 RAIPDVRDGLKPVQRRILYAMFEllNLDKPYKKVARLVGDV--MGKYHpHGDASLYDAIVRMAQDFVG--NIPLLDGQGN 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 779 FGTRTSGGKDsASARYIFTKLSPVTRILFPKDDDLLLD-YLNEDGQRIEPTWYMPIIPTVLVNGAEGIGTGWSTFIPNYN 857
Cdd:pfam00521 77 FGSRIDGDKD-AAMRYTETRLSKIARELFPDIDDDTVDyVPNYDGTEVEPTVLPPIIPNLLVNGAEGIAVGMATNIPPHN 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 858 PREIVANVRRLLNGESM-----VPMDPWYRGFKGTIEKTASKE----GGCTYTITGLYEEVDETTIRITELPIRRWNDDY 928
Cdd:pfam00521 156 LREIIDALIALLDGPEAtllmkYIMGPDFPTGGGIIGKGGIKEayktGRGKITVRAKVEIEDRKTIVITELPYGVWTSDL 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 929 KNFLQSLKTDNGAPFFQDVKAYNDEKsVDFDLILSEENMLAARQEGFLKKFKLTTTIATSNMHLFDKKgviKKYVTPEQI 1008
Cdd:pfam00521 236 IEKIEELVKNGKIKGISDIRDESDRG-VRIVIELKRGADPEVVLNDLYKKTKLQTSFSTNNLVLFDGG---PKYLGLKEI 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 1009 LEEFFDLRFEYYEKRKETVVKNMEIELLKLE------NKARFILAVLSGEIiVNKRKKADIVEDLRQKgftpfprkaesv 1082
Cdd:pfam00521 312 LKEFLDHRLEVYERRKEYLLEKLEERLHILEgllialNNIDFVIEIIRGSI-DRKKAKKNLIEELSEI------------ 378
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 1083 eaaiagavdddaaeepeeilvdpessssyipgsEYDYLLAMAIASLTIEKVEELLADRDKMIIAVADMKKTTPK-----S 1157
Cdd:pfam00521 379 ---------------------------------QADYLLDMRLRRLTKEEVDKLLEEIDELEKEIAELEKLLASekklnD 425
|
....*..
gi 186510360 1158 LWLSDLE 1164
Cdd:pfam00521 426 LWIEELD 432
|
|
| HATPase_TopII-like |
cd16930 |
Histidine kinase-like ATPase domain of eukaryotic topoisomerase II; This family includes the ... |
77-223 |
5.68e-93 |
|
Histidine kinase-like ATPase domain of eukaryotic topoisomerase II; This family includes the histidine kinase-like ATPase (HATpase) domains of human topoisomerase IIA (TopIIA) and TopIIB, Saccharomyces cerevisae TOP2p, and related proteins. These proteins catalyze the passage of DNA double strands through a transient double-strand break in the presence of ATP.
Pssm-ID: 340407 [Multi-domain] Cd Length: 147 Bit Score: 296.17 E-value: 5.68e-93
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 77 YVPGLYKIFDEILVNAADNKQRDAKMDSVQVVIDVEQNLISVCNSGAGVPVEIHQEEGIYVPEMIFGHLLTSSNYDDNVK 156
Cdd:cd16930 1 YVPGLYKIFDEILVNAADNKQRDKSMTCIKVTIDPENNEISVWNNGKGIPVVIHKEEKIYVPEMIFGHLLTSSNYDDDEK 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 186510360 157 KTTGGRNGYGAKLTNIFSTEFIIETADGKRLKKYKQVFENNMGKKSEPVITKCNKSENWTKVTFKPD 223
Cdd:cd16930 81 KVTGGRNGYGAKLCNIFSTEFTVETADSESKKKFKQTWTNNMGKASEPKITPYEKGKDYTKVTFKPD 147
|
|
| 52 |
PHA02592 |
DNA topisomerase II medium subunit; Provisional |
683-1168 |
1.89e-79 |
|
DNA topisomerase II medium subunit; Provisional
Pssm-ID: 222896 [Multi-domain] Cd Length: 439 Bit Score: 269.62 E-value: 1.89e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 683 TYSDFVNKELILFSMADL-QRSIPSMVDGLKPGQRKILFVAF---KKIARKEMKVAQLVGYVSLLSaYHHGEQSLASAII 758
Cdd:PHA02592 7 SLKSIVNNEALEYAMYTVeERAIPNLIDGLKPVQRFVIHRALeyaKGNKEKFDKVAAIAGGVADLG-YHHGETSAQDAGA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 759 GMAQDYvgSNNINLLLPNGQFGTRTsgGKDSASARYIFTKLSPVTRILFPKDDDLLLdylNEDGQRIEPTWYMPIIPTVL 838
Cdd:PHA02592 86 LMANTW--NNNIPLLDGQGNFGSRL--VQKAAAARYIFARVHDNFRKIYKDEDLAPV---HEDPEHIPPAFYLPIIPMVL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 839 VNGAEGIGTGWSTFIPNYNPREIVANVRRLLNGESMVPMDPWYRGFKGTIEKTaskeGGCTYTITGLYEEVDETTIRITE 918
Cdd:PHA02592 159 LNGVSGIATGYATNILPHSPKSVIKAVLAALNGKDITEPKVQFPEFKGEVVEI----EPGSYEIRGTYELNGKTKLHITE 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 919 LPIRRWNDDYKNFLQSLKtDNGApffqdVKAYNDEKSVDFD--LILSEENMLAARQEGFLKKFKLTTTIaTSNMHLFDKK 996
Cdd:PHA02592 235 IPVKYDRETYVAVLDPLE-EKGK-----IVSYDDCTEDGFRfkVTLKREENEEATHEKIMKDFGLIERV-SQNITVINEN 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 997 GVIKKYVTPEQILEEFFDLRFEYYEKRKETVVKNMEIELLKLENKARFILAVLSGEIIVNKRKKADIVEDLRqkgftpfp 1076
Cdd:PHA02592 308 GKLKVYENAEDLIRDFVEIRKTYVQKRIQYEIKETEEAFDLALAKAEFIKRVIAGEIVLQGKTRSELTEELS-------- 379
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 1077 rkaesveaaiagavDDDAAEEPEEILVdpessssyipgseydyllAMAIASLTIEKVEELLADRDKMIIAVADMKKTTPK 1156
Cdd:PHA02592 380 --------------DNKDFGEYADKLV------------------AMNIYSMTSDEREKLQKEAEELEKEHEYWKKTTAK 427
|
490
....*....|..
gi 186510360 1157 SLWLSDLESLDK 1168
Cdd:PHA02592 428 KEYIKDLEELKK 439
|
|
| TOPRIM_TopoIIA |
cd03365 |
TOPRIM_TopoIIA: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the ... |
455-573 |
1.20e-77 |
|
TOPRIM_TopoIIA: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands of the duplex DNA to remove (relax) both positive and negative supercoils in DNA. These enzymes covalently attach to the 5' ends of the cut DNA, separate the free ends of the cleaved strands, pass another region of the duplex through this gap, then rejoin the ends. These proteins also catenate/ decatenate duplex rings. The TOPRIM domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). This glutamate and two aspartates, cluster together to form a highly acid surface patch. The conserved glutamate may act as a general base in strand joining and as a general acid in strand cleavage by topisomerases. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173785 [Multi-domain] Cd Length: 120 Bit Score: 251.84 E-value: 1.20e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 455 CTLILTEGDSAKSLALAGRSVLGNNYCGVFPLRGKLLNVREASTTQITNNKEIENLKKILGLKQNMK-YENVNSLRYGQM 533
Cdd:cd03365 1 CTLILTEGDSAKALAVAGLSVVGRDYYGVFPLRGKLLNVREASHKQIMENAEIQNIKKILGLQHGKSdYESTKSLRYGRL 80
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 186510360 534 MIMTDQDHDGSHIKGLLINFIHSFWPSLLQVPSFLVEFIT 573
Cdd:cd03365 81 MIMTDQDHDGSHIKGLLINFIHSFWPSLLKIPGFLVEFIT 120
|
|
| 39 |
PHA02569 |
DNA topoisomerase II large subunit; Provisional |
39-668 |
1.56e-77 |
|
DNA topoisomerase II large subunit; Provisional
Pssm-ID: 177398 [Multi-domain] Cd Length: 602 Bit Score: 269.32 E-value: 1.56e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 39 SQLEHILLRPDTYIGSIEKHTQTLWVYEKdemvQRPVTYVPGLYKIFDEILVNAADNKQRDAKMDSVQVVIDVEQNLISV 118
Cdd:PHA02569 8 SDREHILKRPGMYIGSVAYEAHERFLFGK----FTQVEYVPGLVKIIDEIIDNSVDEAIRTNFKFANKIDVTIKNNQVTV 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 119 CNSGAGVP---VEIHQEEGIYVPEMIFGHLLTSSNYDDNvKKTTGGRNGYGAKLTNIFSTEFIIETADGKRlkKYKQVFE 195
Cdd:PHA02569 84 SDNGRGIPqamVTTPEGEEIPGPVAAWTRTKAGSNFDDT-NRVTGGMNGVGSSLTNFFSVLFIGETCDGKN--EVTVNCS 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 196 NNMGKKSepVITKCNKSENwTKVTFKPDLKKFNMTELEDDVVALMSKRVFDIAgCLGKSVKVELNGKQIPVKsFTDYVDL 275
Cdd:PHA02569 161 NGAENIS--WSTKPGKGKG-TSVTFIPDFSHFEVNGLDQQYLDIILDRLQTLA-VVFPDIKFTFNGKKVSGK-FKKYAKQ 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 276 YlsaanksrTEDPLprltEKVNDRWEVCVSLSEGQFQQVSFVNSIATIKGGTHVDYVTSQITNHIVAAVNKKNKNANVKA 355
Cdd:PHA02569 236 F--------GDDTI----VQENDNVSIALAPSPDGFRQLSFVNGLHTKNGGHHVDCVMDDICEELIPMIKKKHKIEVTKA 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 356 HnVKNHLW--VFVNALIdNPAFDSQTKETLTLRQSSFGSKCELseDFlKKVGKS---------GVVENLLS-------WA 417
Cdd:PHA02569 304 R-VKECLTivLFVRNMS-NPRFDSQTKERLTSPFGEIRNHIDL--DY-KKIAKQilkteaiimPIIEAALArklaaekAA 378
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 418 DFKQNKDLKKSDGAKtgRVLVEKLDDAAEAggknsrlcTLILTEGDSAKSLALagrSVLGNNYCGVFPLRGKLLNVREAS 497
Cdd:PHA02569 379 ETKAAKKAKKAKVAK--HIKANLIGKDAET--------TLFLTEGDSAIGYLI---EVRDEELHGGYPLRGKVLNTWGMS 445
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 498 TTQITNNKEIENLKKILGLKQNMKYENVNslrYGQMMIMTDQDHDG-SHIKGLLINFIhSFWPSLLQVPSflVEFI-TPI 575
Cdd:PHA02569 446 YADILKNKELFDICAITGLVLGEKAENMN---YKNIAIMTDADVDGkGSIYPLLLAFF-SRWPELFEQGR--IRFVkTPV 519
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 576 VKATRKgtKKVLSFYSMPEYEEWKESLKgnatGWDIKYYKGLGTSTAEEGKEYFSNLGLhkkDFVWEDEQDGEAIELAFS 655
Cdd:PHA02569 520 IIAQVG--KETKWFYSLDEFEKAKDSLK----KWSIRYIKGLGSLRKSEYRRVINNPVY---DVVVLPDDWKELFEMLFG 590
|
650
....*....|...
gi 186510360 656 KKKiEARKNWLSS 668
Cdd:PHA02569 591 DDA-DLRKDWMSQ 602
|
|
| TOPRIM_C |
pfam16898 |
C-terminal associated domain of TOPRIM; TOPRIM_C is found as the C-terminal extension of the ... |
571-700 |
7.17e-75 |
|
C-terminal associated domain of TOPRIM; TOPRIM_C is found as the C-terminal extension of the TOPRIM domain, pfam01751 in metazoa.
Pssm-ID: 465302 [Multi-domain] Cd Length: 127 Bit Score: 243.97 E-value: 7.17e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 571 FITPIVKATRKgtKKVLSFYSMPEYEEWKESLkGNATGWDIKYYKGLGTSTAEEGKEYFSNLGLHKKDFVWEDEQDGEAI 650
Cdd:pfam16898 1 FITPIVKVTKG--KEVISFFSLPEYEEWKEST-PNLKGWKIKYYKGLGTSTSEEAKEYFSNLDKHRKEFKYLGDDDDEAI 77
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 186510360 651 ELAFSKKKIEARKNWLSSYVPGNHLDQRQPKVTYSDFVNKELILFSMADL 700
Cdd:pfam16898 78 DLAFSKKKADDRKEWLRNFNPGTYLDHSTKEISYSDFINKELILFSMADN 127
|
|
| TopoIIA_Trans_ScTopoIIA |
cd03481 |
TopoIIA_Trans_ScTopoIIA: Transducer domain, having a ribosomal S5 domain 2-like fold, of the ... |
267-419 |
6.21e-74 |
|
TopoIIA_Trans_ScTopoIIA: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topo IIA. S. cerevisiae Topo IIA is a homodimer encoded by a single gene. The type IIA enzymes are the predominant form of topoisomerase and are found in some bacteriophages, viruses and archaea, and in all bacteria and eukaryotes. All type IIA topoisomerases are related to each other at amino acid sequence level, though their oligomeric organization sometimes differs. TopoIIA enzymes cut both strands of the duplex DNA to remove (relax) both positive and negative supercoils in DNA. These enzymes covalently attach to the 5' ends of the cut DNA, separate the free ends of the cleaved strands, pass another region of the duplex through this gap, then rejoin the ends. TopoIIA enzymes also catenate/ decatenate duplex rings. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is known to be important in nucleotide hydrolysis and the transduction of structural signals from ATP-binding site to the DNA breakage/reunion regions of the enzymes.
Pssm-ID: 239563 [Multi-domain] Cd Length: 153 Bit Score: 242.58 E-value: 6.21e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 267 KSFTDYVDLYLSAANKSrTEDPLPRLTEKVNDRWEVCVSLSEGQFQQVSFVNSIATIKGGTHVDYVTSQITNHIVAAVNK 346
Cdd:cd03481 1 KSFKDYVKLYLKDANKE-DGPPPPVVYEPVNDRWEVAVALSDGQFQQVSFVNSIATTKGGTHVDYVADQIVKKLDEVVKK 79
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 186510360 347 KNKNANV-KAHNVKNHLWVFVNALIDNPAFDSQTKETLTLRQSSFGSKCELSEDFLKKVGKSGVVENLLSWADF 419
Cdd:cd03481 80 KNKGGINvKPFQVKNHLWIFVNCLIENPSFDSQTKETLTTKPKSFGSKCELSEKFLKKAVKSGIVESVLSWAKF 153
|
|
| TOPRIM_TopoIIA_like |
cd01030 |
TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain ... |
455-573 |
1.33e-58 |
|
TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands of the duplex DNA to remove (relax) both positive and negative supercoils in DNA. These enzymes covalently attach to the 5' ends of the cut DNA, separate the free ends of the cleaved strands, pass another region of the duplex through this gap, then rejoin the ends. These proteins also catenate/ decatenate duplex rings. The TOPRIM domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). The conserved glutamate may act as a general base in strand joining and as a general acid in strand cleavage by topisomerases. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173780 [Multi-domain] Cd Length: 115 Bit Score: 196.96 E-value: 1.33e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 455 CTLILTEGDSAKSLALAGRSVLgnnYCGVFPLRGKLLNVREASTTQITNNKEIENLKKILGLKQNMKYENVNSLRYGQMM 534
Cdd:cd01030 1 CELILVEGDSAGGSAKQGRDRV---FQAVFPLRGKILNVEKASLKKILKNEEIQNIIKALGLGIGKDDFDLDKLRYGKII 77
|
90 100 110
....*....|....*....|....*....|....*....
gi 186510360 535 IMTDQDHDGSHIKGLLINFIHSFWPSLLQVpSFLVEFIT 573
Cdd:cd01030 78 IMTDADVDGSHIRTLLLTFFYRFWPSLLEN-GFLYIAQT 115
|
|
| PRK05559 |
PRK05559 |
DNA topoisomerase IV subunit B; Reviewed |
41-670 |
8.31e-57 |
|
DNA topoisomerase IV subunit B; Reviewed
Pssm-ID: 235501 [Multi-domain] Cd Length: 631 Bit Score: 209.19 E-value: 8.31e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 41 LEHILLRPDTYIGSiekhTQTlwvyekdemvqrpvtyvPGLYKIFDEILVNAADnkqrDAKM---DSVQVVIDvEQNLIS 117
Cdd:PRK05559 19 LEPVRKRPGMYIGS----TDT-----------------RGLHHLVQEVIDNSVD----EALAghgKRIEVTLH-ADGSVS 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 118 VCNSGAGVPVEIHQEEGIYVPEMIFGHLLTSSNYDDNVKKTTGGRNGYGAKLTNIFSTEFIIETA-DGKRlkkYKQVFEN 196
Cdd:PRK05559 73 VRDNGRGIPVGIHPEEGKSGVEVILTKLHAGGKFSNKAYKFSGGLHGVGVSVVNALSSRLEVEVKrDGKV---YRQRFEG 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 197 nmGKKSEP--VITKCNKSENWTKVTFKPDLK-----KFNMTELEDdvvALMSKRVfdiagcLGKSVKVELNGKqIPVKSF 269
Cdd:PRK05559 150 --GDPVGPleVVGTAGKRKTGTRVRFWPDPKifdspKFSPERLKE---RLRSKAF------LLPGLTITLNDE-RERQTF 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 270 ------TDYVDlYLSAANKSRTEDPLPRLTEKVND-RWEVCVS-LSEGQFQQVSFVNSIATIKGGTHV----DYVTSQIT 337
Cdd:PRK05559 218 hyenglKDYLA-ELNEGKETLPEEFVGSFEGEAEGeAVEWALQwTDEGGENIESYVNLIPTPQGGTHEngfrEGLLKAVR 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 338 NHIVAAVNKKNKNANVKAhNVKNHLWVFVNALIDNPAFDSQTKETLTLRQ-----SSFgSKCELSEdFLKKVGKSGvvEN 412
Cdd:PRK05559 297 EFAEKRNLLPKGKKLEGE-DVREGLAAVLSVKIPEPQFEGQTKEKLGSREarrfvSGV-VKDAFDL-WLNQNPELA--EK 371
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 413 LLSWAdfKQNKDLKKSDGAKT-------GRVLVEKLDDAAeagGKNSRLCTLILTEGDSAKSLALAGRSVlgnNYCGVFP 485
Cdd:PRK05559 372 LAEKA--IKAAQARLRAAKKVkrkkktsGPALPGKLADCT---SQDPERTELFLVEGDSAGGSAKQARDR---EFQAILP 443
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 486 LRGKLLNVREASTTQITNNKEIENLKKILGLKQNMKYeNVNSLRYGQMMIMTDQDHDGSHIKGLLINFIHSFWPSllqvp 565
Cdd:PRK05559 444 LRGKILNTWEASLDDVLANEEIHDIIVAIGIGPGDSF-DLEDLRYGKIIIMTDADVDGAHIATLLLTFFYRHFPP----- 517
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 566 sfLVE----FI--TPIVKATRKgtKKVLSFYSMPEYEEWKESLKGNATGWDIKYYKGLGTSTAEEGKEYFSN-------- 631
Cdd:PRK05559 518 --LVEaghvYIalPPLYRVDKG--KKKIYALDEEEKEELLKKLGKKGGKPEIQRFKGLGEMNPDQLWETTMDpetrrlvr 593
|
650 660 670 680
....*....|....*....|....*....|....*....|..
gi 186510360 632 LGLHkkdfvwedeqDGEAIELAFSK---KKIEARKNWLSSYV 670
Cdd:PRK05559 594 VTID----------DAEETEKLVDMlmgKKAEPRREWIEENG 625
|
|
| GyrB |
COG0187 |
DNA gyrase/topoisomerase IV, subunit B [Replication, recombination and repair]; |
41-627 |
3.34e-36 |
|
DNA gyrase/topoisomerase IV, subunit B [Replication, recombination and repair];
Pssm-ID: 439957 [Multi-domain] Cd Length: 635 Bit Score: 147.10 E-value: 3.34e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 41 LEHILLRPDTYIGSiekhtqtlwvyekdemvqrpvTYVPGLYKIFDEILVNAADnkqrDAkM----DSVQVVIDvEQNLI 116
Cdd:COG0187 17 LEAVRKRPGMYIGS---------------------TDERGLHHLVWEIVDNSID----EA-LagycDRIEVTLH-ADGSV 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 117 SVCNSGAGVPVEIHQEEGIYVPEMIFGHLLTSSNYDDNVKKTTGGRNGYGAKLTNIFSTEFIIETA-DGKRlkkYKQVFE 195
Cdd:COG0187 70 TVEDNGRGIPVDIHPKEGKSALEVVLTVLHAGGKFDGGSYKVSGGLHGVGASVVNALSERLEVEVKrDGKI---YRQRFE 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 196 NnmGKKSEPV--ITKCNKSEnwTKVTFKPDLKKFNMTELEDDVVAlmsKRVFDIAgCLGKSVKVELN---GKQIPVKSF- 269
Cdd:COG0187 147 R--GKPVGPLekIGKTDRTG--TTVRFKPDPEIFETTEFDYETLA---ERLRELA-FLNKGLTITLTderEEEPKEETFh 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 270 -----TDYVDlYLSAANKSRTEDPLpRLTEKVND-RWEVCVSLSEGQFQQV-SFVNSIATIKGGTHVD----YVTSQITN 338
Cdd:COG0187 219 yeggiKDFVE-YLNEDKEPLHPEVI-YFEGEKDGiEVEVALQWNDGYSENIhSFVNNINTPEGGTHETgfrtALTRVIND 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 339 HIVAAVNKKNKNANVKAHNVKNHLWVFVNALIDNPAFDSQTKETL------TLRQSSFGSKceLsEDFL---KKVGKSgV 409
Cdd:COG0187 297 YARKNGLLKEKDKNLTGDDVREGLTAVISVKLPEPQFEGQTKTKLgnsearGIVESVVSEK--L-EHYLeenPAEAKK-I 372
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 410 VENLLSWADF----KQNKDLKKSDGAKTGRVLVEKLDDAAEaggKNSRLCTLILTEGDSAKSLALAGRSvlgNNYCGVFP 485
Cdd:COG0187 373 LEKAILAARAreaaRKARELVRRKSALESSGLPGKLADCSS---KDPEESELFIVEGDSAGGSAKQGRD---REFQAILP 446
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 486 LRGKLLNVREASTTQITNNKEIENLKKILGLkqNMKYE-NVNSLRYGQMMIMTDQDHDGSHIKGLLINFIHSFWPSLL-- 562
Cdd:COG0187 447 LRGKILNVEKARLDKILKNEEIRDLITALGT--GIGDDfDLEKLRYHKIIIMTDADVDGAHIRTLLLTFFYRYMRPLIea 524
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 186510360 563 ------QVPSFLVEfitpivkatrKGtKKVLSFYSMPEYEEWKESLKGNAtGWDIKYYKGLGTSTAEEGKE 627
Cdd:COG0187 525 ghvyiaQPPLYRIK----------KG-KKTYYAYSDAELDELLKELKGKK-KVEIQRYKGLGEMNPEQLWE 583
|
|
| gyrB |
PRK05644 |
DNA gyrase subunit B; Validated |
41-618 |
9.18e-32 |
|
DNA gyrase subunit B; Validated
Pssm-ID: 235542 [Multi-domain] Cd Length: 638 Bit Score: 133.30 E-value: 9.18e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 41 LEHILLRPDTYIGSiekhtqtlwvyekdemvqrpvTYVPGLYKIFDEILVNAADnkqrDAkM----DSVQVVIDvEQNLI 116
Cdd:PRK05644 19 LEAVRKRPGMYIGS---------------------TGERGLHHLVYEIVDNSID----EA-LagycDHIEVTIN-EDGSI 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 117 SVCNSGAGVPVEIHQEEGIYVPEMIFGHLLTSSNYDDNVKKTTGGRNGYGAKLTNIFSTEFIIETA-DGKRlkkYKQVFE 195
Cdd:PRK05644 72 TVTDNGRGIPVDIHPKTGKPAVEVVLTVLHAGGKFGGGGYKVSGGLHGVGVSVVNALSTWLEVEVKrDGKI---YYQEYE 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 196 NnmGKKSEPVITKCNKSENWTKVTFKPDLKKFNMTELEDDVVAlmsKRVFDIAgCLGKSVKVELN---GKQIPVKSF--- 269
Cdd:PRK05644 149 R--GVPVTPLEVIGETDETGTTVTFKPDPEIFETTEFDYDTLA---TRLRELA-FLNKGLKITLTderEGEEKEETFhye 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 270 ---TDYVDlYLsaaNKSRT---EDPLprLTEKVNDRWEVCVSL--SEGQFQQV-SFVNSIATIKGGTHVD----YVTSQI 336
Cdd:PRK05644 223 ggiKEYVE-YL---NRNKEplhEEPI--YFEGEKDGIEVEVAMqyNDGYSENIlSFANNINTHEGGTHEEgfktALTRVI 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 337 TNHIVAAVNKKNKNANVKAHNVKNHLWVFVNALIDNPAFDSQTKETL------TLRQSSFGSKceLSEDFLK--KVGKSg 408
Cdd:PRK05644 297 NDYARKNKLLKEKDDNLTGEDVREGLTAVISVKHPEPQFEGQTKTKLgnsevrGIVDSVVSEA--LSEFLEEnpNVAKK- 373
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 409 VVENLLSWAdfkqnkdlKKSDGAKTGRVLVE------------KLDDAAEaggKNSRLCTLILTEGDSAKSLALAGRSvl 476
Cdd:PRK05644 374 IVEKAILAA--------RAREAARKARELTRrksalessslpgKLADCSS---KDPEESELYIVEGDSAGGSAKQGRD-- 440
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 477 gNNYCGVFPLRGKLLNVREASTTQITNNKEIENLkkILGLKQNMKYE-NVNSLRYGQMMIMTDQDHDGSHIKGLLINFIH 555
Cdd:PRK05644 441 -RRFQAILPLRGKILNVEKARLDKILKNEEIRAL--ITALGTGIGDDfDISKLRYHKIIIMTDADVDGAHIRTLLLTFFY 517
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 186510360 556 SFWPSLL--------QVPSFLVefitpivkatRKGTKKVlsFYSMPEYEEWKESLKGNA-TGWDIKYYKGLG 618
Cdd:PRK05644 518 RYMRPLIeagyvyiaQPPLYKI----------KKGGKEY--AYSDEELDEILAELKLKGnPKYGIQRYKGLG 577
|
|
| gyrB |
PRK14939 |
DNA gyrase subunit B; Provisional |
103-553 |
1.10e-24 |
|
DNA gyrase subunit B; Provisional
Pssm-ID: 237860 [Multi-domain] Cd Length: 756 Bit Score: 111.73 E-value: 1.10e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 103 DSVQVVIDVEqNLISVCNSGAGVPVEIHQEEGIYVPEMIFGHLLTSSNYDDNVKKTTGGRNGYGAKLTNIFSTEFIIETA 182
Cdd:PRK14939 59 DDITVTIHAD-GSVSVSDNGRGIPTDIHPEEGVSAAEVIMTVLHAGGKFDQNSYKVSGGLHGVGVSVVNALSEWLELTIR 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 183 -DGKrlkKYKQVFENnmGKKSEP--VITKCNKSEnwTKVTFKPDLKKFNMTELEDDVVAlmsKRVFDIAgCLGKSVKVEL 259
Cdd:PRK14939 138 rDGK---IHEQEFEH--GVPVAPlkVVGETDKTG--TEVRFWPSPEIFENTEFDYDILA---KRLRELA-FLNSGVRIRL 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 260 ----NGKQIP------VKSFTDYVdlylsaaNKSRT---EDPLPRLTEKvnDRWEVCVSL--SEGQFQQV-SFVNSIATI 323
Cdd:PRK14939 207 kderDGKEEEfhyeggIKAFVEYL-------NRNKTplhPNIFYFSGEK--DGIGVEVALqwNDSYQENVlCFTNNIPQR 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 324 KGGTHV----DYVTSQITNHIVAAVNKKNKNANVKAHNVKNHLWVFVNALIDNPAFDSQTKETLtlrqssfGSkcelSEd 399
Cdd:PRK14939 278 DGGTHLagfrAALTRTINNYIEKEGLAKKAKVSLTGDDAREGLTAVLSVKVPDPKFSSQTKDKL-------VS----SE- 345
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 400 fLKKVGKSGVVENLLSWadFKQNKDLKKSdgaktgrvLVEKLDDAA---EA----------------GG----------K 450
Cdd:PRK14939 346 -VRPAVESLVNEKLSEF--LEENPNEAKI--------IVGKIIDAArarEAarkareltrrkgaldiAGlpgkladcqeK 414
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 451 NSRLCTLILTEGDSAKSLALAGRS-----VLgnnycgvfPLRGKLLNVREASTTQITNNKEIENLKKILGL---KQNMky 522
Cdd:PRK14939 415 DPALSELYLVEGDSAGGSAKQGRDrkfqaIL--------PLKGKILNVEKARFDKMLSSQEIGTLITALGCgigRDEF-- 484
|
490 500 510
....*....|....*....|....*....|.
gi 186510360 523 eNVNSLRYGQMMIMTDQDHDGSHIKGLLINF 553
Cdd:PRK14939 485 -NPDKLRYHKIIIMTDADVDGSHIRTLLLTF 514
|
|
| DNA_gyraseB |
pfam00204 |
DNA gyrase B; This family represents the second domain of DNA gyrase B which has a ribosomal ... |
269-427 |
2.65e-23 |
|
DNA gyrase B; This family represents the second domain of DNA gyrase B which has a ribosomal S5 domain 2-like fold. This family is structurally related to PF01119.
Pssm-ID: 425522 [Multi-domain] Cd Length: 173 Bit Score: 98.46 E-value: 2.65e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 269 FTDYVDlYLSAANKSRTEDPLPRLTEKVNDRWEVCVSL---SEGQFQQVSFVNSIATIKGGTHVDYVTSQIT----NHIV 341
Cdd:pfam00204 2 LKDFVE-ELNKDKKPLHKEIIYFEGESPDNRIEVEVALqwtDSYSENILSFVNNIATPEGGTHVDGFKSALTrtinEYAK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 342 AAVNKKNKNANVKAHNVKNHLWVFVNALIDNPAFDSQTKETLTLRQSSFGSKCELSEDFLKKVGK-SGVVENLLSWADFK 420
Cdd:pfam00204 81 KKGLLKKKDEKITGEDIREGLTAVVSVKIPDPQFEGQTKEKLGNPEVKSAVEKIVSEKLEEFLEEnPEIAKKILEKALQA 160
|
....*..
gi 186510360 421 QNKDLKK 427
Cdd:pfam00204 161 AKARLAA 167
|
|
| PRK09631 |
PRK09631 |
DNA topoisomerase IV subunit A; Provisional |
684-920 |
1.07e-22 |
|
DNA topoisomerase IV subunit A; Provisional
Pssm-ID: 236598 [Multi-domain] Cd Length: 635 Bit Score: 104.79 E-value: 1.07e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 684 YSDFVNKElilfsmadlqRSIPSMVDGLKPGQRKILFVAFKKIARKEMKVAQLVGYVSllsAYH-HGEQSLASAIIGMAq 762
Cdd:PRK09631 15 YASYVIKD----------RAIPDVIDGLKPVQRRILHSLFEMHDGKFHKVANVVGNTM---KYHpHGDASIYEALVNLA- 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 763 dyvgsnNINLLLP-NGQFGTRTSGgkDSASA-RYIFTKLSPVTR-ILFPKDDDLLLDYLneDGQRIEPTWYMPIIPTVLV 839
Cdd:PRK09631 81 ------NKDLFIDkQGNFGNLFTG--DPASAaRYIECRLTPLAKeVLYNKEITEYEPSY--DGRNNEPLCLPAKIPVILI 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 840 NGAEGIGTGWSTFIPNYNPREIVANVRRLLNGESMVPMDPWYRGfkGTIEKTASKEGGCTYTITGLYEEVDETTIRITEL 919
Cdd:PRK09631 151 QGAEGIAVGMATKILPHNFNEILQAVKSELLGESFALYPDFPTG--GIVDVSEYADGNGKVLVRAKIETKDEKTIVIREI 228
|
.
gi 186510360 920 P 920
Cdd:PRK09631 229 P 229
|
|
| HATPase_GyrB-like |
cd16928 |
Histidine kinase-like ATPase domain of the B subunit of DNA gyrase; This family includes ... |
81-260 |
2.82e-21 |
|
Histidine kinase-like ATPase domain of the B subunit of DNA gyrase; This family includes histidine kinase-like ATPase domain of the B subunit of DNA gyrase. Bacterial DNA gyrase is a type II topoisomerase (type II as it transiently cleaves both strands of DNA) which catalyzes the introduction of negative supercoils into DNA, possibly by a mechanism in which one segment of the double-stranded DNA substrate is passed through a transient break in a second segment. It consists of GyrA and GyrB subunits in an A2B2 stoichiometry; GyrA subunits catalyze strand-breakage and reunion reactions, and GyrB subunits hydrolyze ATP. DNA gyrase is found in bacteria, plants and archaea, but as it is absent in humans it is a possible drug target for the treatment of bacterial and parasite infections.
Pssm-ID: 340405 [Multi-domain] Cd Length: 180 Bit Score: 92.60 E-value: 2.82e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 81 LYKIFDEILVNAADnkqrDAKM---DSVQVVIDvEQNLISVCNSGAGVPVEIHQEEGIYVPEMIFGHLLTSSNYDDNVKK 157
Cdd:cd16928 1 LHHLVWEIVDNSID----EALAgyaTEIEVTLH-EDNSITVEDNGRGIPVDIHPKTGKSAVEVVLTVLHAGGKFDGGSYK 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 158 TTGGRNGYGAKLTNIFSTEFIIE-TADGkrlKKYKQVFENnmGKKSEPVITKCNKSENWTKVTFKPDLKKFNMTELEDDV 236
Cdd:cd16928 76 VSGGLHGVGVSVVNALSERLEVEvKRDG---KIYRQEFSR--GGPLTPLEVIGETKKTGTTVRFWPDPEIFEKTEFDFDT 150
|
170 180
....*....|....*....|....
gi 186510360 237 VAlmsKRVFDIAgCLGKSVKVELN 260
Cdd:cd16928 151 LK---RRLRELA-FLNKGLKIVLE 170
|
|
| TOPRIM_TopoIIA_GyrB |
cd03366 |
TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain ... |
455-563 |
2.90e-19 |
|
TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the duplex DNA to remove (relax) both positive and negative supercoils in DNA. These enzymes covalently attach to the 5' ends of the cut DNA, separate the free ends of the cleaved strands, pass another region of the duplex through this gap, then rejoin the ends. These proteins also catenate/ decatenate duplex rings. DNA gyrase is more effective at relaxing supercoils than decatentating DNA. DNA gyrase in addition inserts negative supercoils in the presence of ATP. The TOPRIM domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). The conserved glutamate may act as a general base in strand joining and as a general acid in strand cleavage by topisomerases. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173786 [Multi-domain] Cd Length: 114 Bit Score: 84.63 E-value: 2.90e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 455 CTLILTEGDSAKSLALAGRSvlgNNYCGVFPLRGKLLNVREASTTQITNNKEIENLKKILGLKQNMKYeNVNSLRYGQMM 534
Cdd:cd03366 1 SELYIVEGDSAGGSAKQGRD---RRFQAILPLRGKILNVEKARLDKILKNEEIRALITALGTGIGEDF-DLEKLRYHKII 76
|
90 100
....*....|....*....|....*....
gi 186510360 535 IMTDQDHDGSHIKGLLINFIHSFWPSLLQ 563
Cdd:cd03366 77 IMTDADVDGAHIRTLLLTFFFRYMRPLIE 105
|
|
| gyrA |
TIGR01063 |
DNA gyrase, A subunit; This model describes the common type II DNA topoisomerase (DNA gyrase). ... |
702-863 |
7.03e-17 |
|
DNA gyrase, A subunit; This model describes the common type II DNA topoisomerase (DNA gyrase). Two apparently independently arising families, one in the Proteobacteria and one in Gram-positive lineages, are both designated toposisomerase IV. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273423 [Multi-domain] Cd Length: 800 Bit Score: 86.59 E-value: 7.03e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 702 RSIPSMVDGLKPGQRKILFVAFKK---IARKEMKVAQLVGYVslLSAYH-HGEQSLASAIIGMAQDYvgsnNINLLLPNG 777
Cdd:TIGR01063 25 RALPDVRDGLKPVHRRILYAMYELgltPDKPYKKSARIVGDV--MGKYHpHGDSAIYDTLVRMAQDF----SLRYPLVDG 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 778 Q--FGtrtSGGKDSASA-RYIFTKLSPVT-RILFPKDDDLLLDYLNEDGQRIEPTWYMPIIPTVLVNGAEGIGTGWSTFI 853
Cdd:TIGR01063 99 QgnFG---SIDGDPPAAmRYTEARLTKIAeELLRDIDKETVDFVPNYDGSEQEPTVLPSRFPNLLVNGSSGIAVGMATNI 175
|
170
....*....|
gi 186510360 854 PNYNPREIVA 863
Cdd:TIGR01063 176 PPHNLGEIID 185
|
|
| PRK09630 |
PRK09630 |
DNA topoisomerase IV subunit A; Provisional |
700-919 |
3.28e-16 |
|
DNA topoisomerase IV subunit A; Provisional
Pssm-ID: 170022 Cd Length: 479 Bit Score: 83.41 E-value: 3.28e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 700 LQRSIPSMVDGLKPGQRKILFVAFKKIARKEMKVAQLVGYVSLLsaYHHGEQSLASAIIGMAqdyvgsNNINLLLPNGQF 779
Cdd:PRK09630 21 LERAIPHILDGLKPVQRRLLWTLFRMDDGKMHKVANIAGRTMAL--HPHGDAPIVEALVVLA------NKGYLIDTQGNF 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 780 GTRTSgGKDSASARYIFTKLSPVTR-ILFpkDDDLLLDYLNEDGQRIEPTWYMPIIPTVLVNGAEGIGTGWSTFIPNYNP 858
Cdd:PRK09630 93 GNPLT-GDPHAAARYIEARLSPLAKeVLF--NTDLMTFHDSYDGREKEPDILPAKLPLLLLHGVDGIAVGMTTKIFPHNF 169
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 186510360 859 REIVANVRRLLNGESMVPMDPWYRGfkGTIEKTASKEGGCTYTITGLYEEVDETTIRITEL 919
Cdd:PRK09630 170 CELLEAQIAILNDQPFTLLPDFPSG--GTMDASEYQDGLGSITLRASIDIINDKTLLIKEI 228
|
|
| PTZ00109 |
PTZ00109 |
DNA gyrase subunit b; Provisional |
301-563 |
6.85e-16 |
|
DNA gyrase subunit b; Provisional
Pssm-ID: 240272 [Multi-domain] Cd Length: 903 Bit Score: 83.39 E-value: 6.85e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 301 EVCVSLSEGQF--QQVSFVNSIATIkGGTHVD---YVTSQITNHivaavnkKNKNANVKAHNVKN--------HLWVFVN 367
Cdd:PTZ00109 410 EVSLSWSLESYtaLIKSFANNVSTT-AGTHIDgfkYAITRCVNG-------NIKKNGYFKGNFVNipgefireGMTAIIS 481
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 368 ALIDNPAFDSQTKETLtlrqssfGSKcelsedFLKKVGKSGVVE----------NLLSWADFKQNKDLKKSDGAKTGRVL 437
Cdd:PTZ00109 482 VKLNGAEFDGQTKTKL-------GNH------LLKTILESIVFEqlseilefepNLLLAIYNKSLAAKKAFEEAKAAKDL 548
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 438 VEKLDDAAEAGGKNSRL--CT--------LILTEGDSAKSLALAGRSvlgNNYCGVFPLRGKLLNVRE-ASTTQITNNKE 506
Cdd:PTZ00109 549 IRQKNNQYYSTILPGKLvdCIsddierneLFIVEGESAAGNAKQARN---REFQAVLPLKGKILNIEKiKNNKKVFENSE 625
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 507 IENLKKILGL---------------KQNMKYENV----------------NSLRYGQMMIMTDQDHDGSHIKGLLINFIH 555
Cdd:PTZ00109 626 IKLLITSIGLsvnpvtwrqydlshgTKASKDESVqnnnstltkkknslfdTPLRYGKIILLTDADVDGEHLRILLLTLLY 705
|
....*...
gi 186510360 556 SFWPSLLQ 563
Cdd:PTZ00109 706 RFCPSLYE 713
|
|
| PRK05561 |
PRK05561 |
DNA topoisomerase 4 subunit A; |
700-869 |
2.02e-14 |
|
DNA topoisomerase 4 subunit A;
Pssm-ID: 235503 [Multi-domain] Cd Length: 742 Bit Score: 78.61 E-value: 2.02e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 700 LQRSIPSMVDGLKPGQRKILF----------VAFKKIARkemkvaqLVGYVslLSAYH-HGEQSLASAIIGMAQDYvgSN 768
Cdd:PRK05561 32 MDRALPDVRDGLKPVQRRILYamselgltpdAKFKKSAR-------VVGDV--LGKYHpHGDSSIYDAMVRMAQDF--SY 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 769 NINLLLPNGQFGTRtsGGKDSASARYIFTKLSPVTRIL----------FpkdddllldYLNEDGQRIEPTWyMP-IIPTV 837
Cdd:PRK05561 101 RYPLVDGQGNFGSI--DGDPAAAMRYTEARLSPIAELLleeidegtvdF---------VPNFDGTLKEPTV-LPaRFPNL 168
|
170 180 190
....*....|....*....|....*....|..
gi 186510360 838 LVNGAEGIGTGWSTFIPNYNPREIVANVRRLL 869
Cdd:PRK05561 169 LLNGATGIAVGMATDIPPHNLREVIDAAIHLI 200
|
|
| PRK12758 |
PRK12758 |
DNA gyrase/topoisomerase IV subunit A; |
700-920 |
2.63e-12 |
|
DNA gyrase/topoisomerase IV subunit A;
Pssm-ID: 237192 [Multi-domain] Cd Length: 869 Bit Score: 71.57 E-value: 2.63e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 700 LQRSIPSMVDGLKPGQRKILFvafkkiARKEM------KVAQLVGYVsllSAYH-HGEQSLASAIIGMAQDyvgsnniNL 772
Cdd:PRK12758 40 LERAVPHIEDGLKPVQRRILH------SMKEMddgrynKVANVVGHT---MQYHpHGDASIGDALVQLGQK-------DL 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 773 LL-PNGQFGT-RTsgGKDSASARYIFTKLSPVT-RILF-PKDDDLLLDYlneDGQRIEPTwYMPI-IPTVLVNGAEGIGT 847
Cdd:PRK12758 104 LIdTQGNWGNiLT--GDGAAAPRYIEARLSKFAlEVVFnPKTTEWQLSY---DGRKKEPV-TLPVkFPLLLAQGAEGIAV 177
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 186510360 848 GWSTFIPNYNPREIVANVRRLLNGESMvpmdPWYRGFK--GTIEKTASKEG--GCTYTITGLYEEVDETTIRITELP 920
Cdd:PRK12758 178 GLSTKILPHNFNELIDASIAYLKGKEF----KLYPDFPtgGIIDVSNYNDGerGGRVRVRAKIEKLDKKTLVITEIP 250
|
|
| TopoII_MutL_Trans |
cd00329 |
MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the ... |
276-384 |
3.04e-12 |
|
MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of type II DNA topoisomerases (Topo II) and DNA mismatch repair (MutL/MLH1/PMS2) proteins. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is known to be important in nucleotide hydrolysis and the transduction of structural signals from ATP-binding site to the DNA breakage/reunion regions of the enzymes. The GyrB dimerizes in response to ATP binding, and is homologous to the N-terminal half of eukaryotic Topo II and the ATPase fragment of MutL. Type II DNA topoisomerases catalyze the ATP-dependent transport of one DNA duplex through another, in the process generating transient double strand breaks via covalent attachments to both DNA strands at the 5' positions. Included in this group are proteins similar to human MLH1 and PMS2. MLH1 forms a heterodimer with PMS2 which functions in meiosis and in DNA mismatch repair (MMR). Cells lacking either hMLH1 or hPMS2 have a strong mutator phenotype and display microsatellite instability (MSI). Mutation in hMLH1 accounts for a large fraction of Lynch syndrome (HNPCC) families.
Pssm-ID: 238202 [Multi-domain] Cd Length: 107 Bit Score: 64.20 E-value: 3.04e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 276 YLSAANKSRTEDPLPRLTEKVND-RWEVCVSLSE----GQFQQVSFVNSIATIKGGTHVDYVTSQITNHIvaavnkknkn 350
Cdd:cd00329 4 RLAEILGDKVADKLIYVEGESDGfRVEGAISYPDsgrsSKDRQFSFVNGRPVREGGTHVKAVREAYTRAL---------- 73
|
90 100 110
....*....|....*....|....*....|....*..
gi 186510360 351 anvKAHNVKNHLWVFVNALIDN--PAFD-SQTKETLT 384
Cdd:cd00329 74 ---NGDDVRRYPVAVLSLKIPPslVDVNvHPTKEEVR 107
|
|
| PRK13979 |
PRK13979 |
DNA topoisomerase IV subunit A; Provisional |
702-862 |
1.78e-11 |
|
DNA topoisomerase IV subunit A; Provisional
Pssm-ID: 237576 [Multi-domain] Cd Length: 957 Bit Score: 68.98 E-value: 1.78e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 702 RSIPSMVDGLKPGQRKILFVAFKKIA---RKEMKVAQLVGyvSLLSAYH-HGEQSLASAIIGMAQDYvgSNNINLLLPNG 777
Cdd:PRK13979 37 RALPDVRDGLKPVHRRILYGAYMLKAfpdKPYYKSARIVG--DILGKYHpHGDSSVYDAMVILAQDF--TTRMPLIDGHG 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 778 QFGtrtSGGKDSASA-RYIFTKLSPVT-RILFPKDDDLLLDYLNEDGQRIEPTWYMPIIPTVLVNGAEGIGTGWSTFIPN 855
Cdd:PRK13979 113 NWG---SIDGDSAAAmRYTEARLTPIAmEMLRDIDKDVVNMVDNYSDSEKEPEVLPARYPNLLVNGAFGIAVGLATNIPP 189
|
....*..
gi 186510360 856 YNPREIV 862
Cdd:PRK13979 190 HNLKEVI 196
|
|
| PRK05560 |
PRK05560 |
DNA gyrase subunit A; Validated |
702-862 |
4.18e-11 |
|
DNA gyrase subunit A; Validated
Pssm-ID: 235502 [Multi-domain] Cd Length: 805 Bit Score: 67.75 E-value: 4.18e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 702 RSIPSMVDGLKPGQRKILF----------VAFKKIARkemkvaqLVGYVslLSAYH-HGEQSLASAIIGMAQDYvgsnni 770
Cdd:PRK05560 29 RALPDVRDGLKPVHRRILYamnelgntpdKPYKKSAR-------IVGDV--MGKYHpHGDSAVYDALVRMAQDF------ 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 771 NLLLP--NGQ--FGtrtSGGKDSASA-RYIFTKLSPVTRIL----------FpkdddllldYLNEDGQRIEPTwYMPI-I 834
Cdd:PRK05560 94 SMRYPlvDGQgnFG---SIDGDPAAAmRYTEARMSKIAHELladidketvdF---------VPNYDGSEQEPT-VLPArF 160
|
170 180
....*....|....*....|....*...
gi 186510360 835 PTVLVNGAEGIGTGWSTFIPNYNPREIV 862
Cdd:PRK05560 161 PNLLVNGSSGIAVGMATNIPPHNLGEVI 188
|
|
| GyrA |
COG0188 |
DNA gyrase/topoisomerase IV, subunit A [Replication, recombination and repair]; |
702-869 |
5.87e-11 |
|
DNA gyrase/topoisomerase IV, subunit A [Replication, recombination and repair];
Pssm-ID: 439958 [Multi-domain] Cd Length: 804 Bit Score: 67.37 E-value: 5.87e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 702 RSIPSMVDGLKPGQRKILF----------VAFKKIARkemkvaqLVGYVslLSAYH-HGEQSLASAIIGMAQDYvgsnNI 770
Cdd:COG0188 34 RALPDVRDGLKPVHRRILYamhelgltpdKPYKKSAR-------VVGDV--MGKYHpHGDSAVYDALVRMAQDF----SM 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 771 NLLLPNGQ--FGTRtsGGkDSASA-RYIFTKLSPVTRIL----------FpkdddllldYLNEDGQRIEPTwYMP-IIPT 836
Cdd:COG0188 101 RYPLVDGQgnFGSI--DG-DPAAAmRYTEARLAKIAEELladidkdtvdF---------VPNYDGSEQEPT-VLPaRFPN 167
|
170 180 190
....*....|....*....|....*....|...
gi 186510360 837 VLVNGAEGIGTGWSTFIPNYNPREIVANVRRLL 869
Cdd:COG0188 168 LLVNGSSGIAVGMATNIPPHNLGEVIDACIALI 200
|
|
| TopoII_Trans_DNA_gyrase |
cd00822 |
TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the ... |
271-447 |
3.26e-08 |
|
TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are heterodimers composed of two subunits. The type IIA enzymes are the predominant form of topoisomerase and are found in some bacteriophages, viruses and archaea, and in all bacteria and eukaryotes. All type IIA topoisomerases are related to each other at amino acid sequence level, though their oligomeric organization sometimes differs. TopoIIA enzymes cut both strands of the duplex DNA to remove (relax) both positive and negative supercoils in DNA. These enzymes covalently attach to the 5' ends of the cut DNA, separate the free ends of the cleaved strands, pass another region of the duplex through this gap, then rejoin the ends. TopoIIA enzymes also catenate/ decatenate duplex rings. E.coli DNA gyrase is a heterodimer composed of two subunits. E. coli DNA gyrase B subunit is known to be important in nucleotide hydrolysis and the transduction of structural signals from ATP-binding site to the DNA breakage/reunion regions of the enzymes.
Pssm-ID: 238419 [Multi-domain] Cd Length: 172 Bit Score: 54.87 E-value: 3.26e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 271 DYVDlYLSAANKSRTEDPLPRLTEKVNDRWEVCVSLSEGQFQQV-SFVNSIATIKGGTHVD----YVTSQITNHIVAAVN 345
Cdd:cd00822 5 DFVE-ELNKDKEPLHEEPIYIEGEKDGVEVEVALQWTDSYSENIlSFVNNIPTPEGGTHETgfraALTRAINDYAKKNNL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 346 KKNKNANVKAHNVKNHLWVFVNALIDNPAFDSQTKETLTLRQssfgskcelsedfLKKVGKSGVVENLLSWadFKQNKDl 425
Cdd:cd00822 84 LKKKDVKLTGDDIREGLTAVISVKVPEPQFEGQTKDKLGNSE-------------VRSIVESAVREALEEW--LEENPE- 147
|
170 180
....*....|....*....|..
gi 186510360 426 kksdgakTGRVLVEKLDDAAEA 447
Cdd:cd00822 148 -------EAKKILEKAILAAKA 162
|
|
| Toprim |
pfam01751 |
Toprim domain; This is a conserved region from DNA primase. This corresponds to the Toprim ... |
456-553 |
1.49e-06 |
|
Toprim domain; This is a conserved region from DNA primase. This corresponds to the Toprim domain common to DnaG primases, topoisomerases, OLD family nucleases and RecR proteins. Both DnaG motifs IV and V are present in the alignment, the DxD (V) motif may be involved in Mg2+ binding and mutations to the conserved glutamate (IV) completely abolish DnaG type primase activity. DNA primase EC:2.7.7.6 is a nucleotidyltransferase it synthesizes the oligoribonucleotide primers required for DNA replication on the lagging strand of the replication fork; it can also prime the leading stand and has been implicated in cell division. This family also includes the atypical archaeal A subunit from type II DNA topoisomerases. Type II DNA topoisomerases catalyze the relaxation of DNA supercoiling by causing transient double strand breaks.
Pssm-ID: 396354 [Multi-domain] Cd Length: 93 Bit Score: 47.74 E-value: 1.49e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 456 TLILTEGDS-AKSLAlagrSVLGNNYCGVFPLRGKLLNVREASTTQItnnkeIENLKKILglkqnmkyenvnsLRYGQMM 534
Cdd:pfam01751 1 ELIIVEGPSdAIALE----KALGGGFQAVVAVLGHLLSLEKGPKKKA-----LKALKELA-------------LKAKEVI 58
|
90
....*....|....*....
gi 186510360 535 IMTDQDHDGSHIKGLLINF 553
Cdd:pfam01751 59 LATDPDREGEAIALKLLEL 77
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
80-226 |
9.46e-06 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 45.82 E-value: 9.46e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 80 GLYKIFDEILVNAADNKqrdAKMDSVQVVIDVEQNL-ISVCNSGAGVPVEIHqeegiyvpEMIFGHLLTSSnyddnvkKT 158
Cdd:pfam02518 5 RLRQVLSNLLDNALKHA---AKAGEITVTLSEGGELtLTVEDNGIGIPPEDL--------PRIFEPFSTAD-------KR 66
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 186510360 159 TGGRNGYGAKLTNIfstefIIETADGKrlkkykqvfennmgkksepvITKCNKSENWTKVTFKPDLKK 226
Cdd:pfam02518 67 GGGGTGLGLSIVRK-----LVELLGGT--------------------ITVESEPGGGTTVTLTLPLAQ 109
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| TOPRIM |
cd00188 |
Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type ... |
455-557 |
7.10e-05 |
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Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from bacterial and archaea, and bacterial DNA repair proteins of the RecR/M family. This domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). This glutamate and two aspartates, cluster together to form a highly acid surface patch. The conserved glutamate may act as a general base in nucleotide polymerization by primases and in strand joining in topoisomerases and, as a general acid in strand cleavage by topisomerases and nucleases. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173773 [Multi-domain] Cd Length: 83 Bit Score: 42.80 E-value: 7.10e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186510360 455 CTLILTEGDS-AKSLALAGRsvlgnNYCGVFPLRGKLlnvreasttqitNNKEIENLKKILGlkqnmkyenvnslRYGQM 533
Cdd:cd00188 1 KKLIIVEGPSdALALAQAGG-----YGGAVVALGGHA------------LNKTRELLKRLLG-------------EAKEV 50
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90 100
....*....|....*....|....
gi 186510360 534 MIMTDQDHDGSHIKGLLINFIHSF 557
Cdd:cd00188 51 IIATDADREGEAIALRLLELLKSL 74
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