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Conserved domains on  [gi|186478055|ref|NP_001117215|]
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translocon at the outer envelope membrane of chloroplasts 33 [Arabidopsis thaliana]

Protein Classification

P-loop NTPase family protein( domain architecture ID 1562424)

P-loop NTPase (nucleoside triphosphate hydrolase) family protein contains two conserved sequence signatures, the Walker A motif (the P-loop proper) and Walker B motif which bind, respectively, the beta and gamma phosphate moieties of the bound nucleotide (typically ATP or GTP), and a Mg(2+) cation

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
P-loop_NTPase super family cl38936
P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain ...
1-296 8.08e-156

P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain superfamily are characterized by a conserved nucleotide phosphate-binding motif, also referred to as the Walker A motif (GxxxxGK[S/T], where x is any residue), and the Walker B motif (hhhh[D/E], where h is a hydrophobic residue). The Walker A and B motifs bind the beta-gamma phosphate moiety of the bound nucleotide (typically ATP or GTP) and the Mg2+ cation, respectively. The P-loop NTPases are involved in diverse cellular functions, and they can be divided into two major structural classes: the KG (kinase-GTPase) class which includes Ras-like GTPases and its circularly permutated YlqF-like; and the ASCE (additional strand catalytic E) class which includes ATPase Binding Cassette (ABC), DExD/H-like helicases, 4Fe-4S iron sulfur cluster binding proteins of NifH family, RecA-like F1-ATPases, and ATPases Associated with a wide variety of Activities (AAA). Also included are a diverse set of nucleotide/nucleoside kinase families.


The actual alignment was detected with superfamily member TIGR00991:

Pssm-ID: 476819  Cd Length: 313  Bit Score: 437.41  E-value: 8.08e-156
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186478055    1 MGSL--VREWVGFQQFPAATQEKLIEFFGKLKQKDMNSMTVLVLGKGGVGKSSTVNSLIGEQVVRVSPFQAEGLRPVMVS 78
Cdd:TIGR00991   1 MASPqtPREWVGIQQFPPATQTKLLELLGKLKEEDVSSLTILVMGKGGVGKSSTVNSIIGERIATVSAFQSEGLRPMMVS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186478055   79 RTMGGFTINIIDTPGLVEAGYVNHQALELIKGFLVNRTIDVLLYVDRLDVYRVDELDKQVVIAITQTFGKEIWCKTLLVL 158
Cdd:TIGR00991  81 RTRAGFTLNIIDTPGLIEGGYINDQAVNIIKRFLLGKTIDVLLYVDRLDAYRVDTLDGQVIRAITDSFGKDIWRKSLVVL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186478055  159 THAQFSPPDELSYETFSSKRSDSLLKTIRAGSKMRKQEFEDSAIAVVYAENSGRCSKNDKDEKALPNGEAWIPNLVKAIT 238
Cdd:TIGR00991 161 THAQFSPPDGLEYNDFFSKRSEALLRVIHSGAGLKKRDYQDFPIPVALVENSGRCKKNESDEKILPDGTPWIPKLMKEIT 240
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 186478055  239 DVATNQRKAIHVDKKMVDGSYSDDKGKKLIPLIIGAQYLIV-KMIQGAIRNDIKTSGKP 296
Cdd:TIGR00991 241 EVISNGSKPIHVDKKLIDGPNPNNRGKMFIPLIFAVQYLLVvKPIRRAIHADIANEKKD 299
 
Name Accession Description Interval E-value
3a0901s02IAP34 TIGR00991
GTP-binding protein (Chloroplast Envelope Protein Translocase); [Transport and binding ...
1-296 8.08e-156

GTP-binding protein (Chloroplast Envelope Protein Translocase); [Transport and binding proteins, Nucleosides, purines and pyrimidines]


Pssm-ID: 130064  Cd Length: 313  Bit Score: 437.41  E-value: 8.08e-156
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186478055    1 MGSL--VREWVGFQQFPAATQEKLIEFFGKLKQKDMNSMTVLVLGKGGVGKSSTVNSLIGEQVVRVSPFQAEGLRPVMVS 78
Cdd:TIGR00991   1 MASPqtPREWVGIQQFPPATQTKLLELLGKLKEEDVSSLTILVMGKGGVGKSSTVNSIIGERIATVSAFQSEGLRPMMVS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186478055   79 RTMGGFTINIIDTPGLVEAGYVNHQALELIKGFLVNRTIDVLLYVDRLDVYRVDELDKQVVIAITQTFGKEIWCKTLLVL 158
Cdd:TIGR00991  81 RTRAGFTLNIIDTPGLIEGGYINDQAVNIIKRFLLGKTIDVLLYVDRLDAYRVDTLDGQVIRAITDSFGKDIWRKSLVVL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186478055  159 THAQFSPPDELSYETFSSKRSDSLLKTIRAGSKMRKQEFEDSAIAVVYAENSGRCSKNDKDEKALPNGEAWIPNLVKAIT 238
Cdd:TIGR00991 161 THAQFSPPDGLEYNDFFSKRSEALLRVIHSGAGLKKRDYQDFPIPVALVENSGRCKKNESDEKILPDGTPWIPKLMKEIT 240
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 186478055  239 DVATNQRKAIHVDKKMVDGSYSDDKGKKLIPLIIGAQYLIV-KMIQGAIRNDIKTSGKP 296
Cdd:TIGR00991 241 EVISNGSKPIHVDKKLIDGPNPNNRGKMFIPLIFAVQYLLVvKPIRRAIHADIANEKKD 299
Toc34_like cd01853
Translocon at the Outer-envelope membrane of Chloroplasts 34-like (Toc34-like); The Toc34-like ...
6-251 3.40e-135

Translocon at the Outer-envelope membrane of Chloroplasts 34-like (Toc34-like); The Toc34-like (Translocon at the Outer-envelope membrane of Chloroplasts) family contains several Toc proteins, including Toc34, Toc33, Toc120, Toc159, Toc86, Toc125, and Toc90. The Toc complex at the outer envelope membrane of chloroplasts is a molecular machine of ~500 kDa that contains a single Toc159 protein, four Toc75 molecules, and four or five copies of Toc34. Toc64 and Toc12 are associated with the translocon, but do not appear to be part of the core complex. The Toc translocon initiates the import of nuclear-encoded preproteins from the cytosol into the organelle. Toc34 and Toc159 are both GTPases, while Toc75 is a beta-barrel integral membrane protein. Toc159 is equally distributed between a soluble cytoplasmic form and a membrane-inserted form, suggesting that assembly of the Toc complex is dynamic. Toc34 and Toc75 act sequentially to mediate docking and insertion of Toc159 resulting in assembly of the functional translocon.


Pssm-ID: 206652  Cd Length: 248  Bit Score: 382.44  E-value: 3.40e-135
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186478055   6 REWVGFQQFPAATQEKLIEFFGKLKQKDMNSMTVLVLGKGGVGKSSTVNSLIGEQVVRVSPFQAEGLRPVMVSRTMGGFT 85
Cdd:cd01853    1 REWVGFQFFPDATQTKLHELEAKLKKELDFSLTILVLGKTGVGKSSTINSIFGERKVSVSAFQSETLRPREVSRTVDGFK 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186478055  86 INIIDTPGLVEA--GYVNHQALELIKGFLVNRTIDVLLYVDRLDVYRVDELDKQVVIAITQTFGKEIWCKTLLVLTHAQF 163
Cdd:cd01853   81 LNIIDTPGLLESqdQRVNRKILSIIKRFLKKKTIDVVLYVDRLDMYRVDNLDVPLLRAITDSFGPSIWRNAIVVLTHAQS 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186478055 164 SPPDELSYETFSSKRSDSLLKTIRAGSKMRKQEFEDSAIAVVYAENSGRCSKNDKDEKALPNGEAWIPNLVKAITDVATN 243
Cdd:cd01853  161 SPPDGPNGTPFSYDRFVAQRKHIVQQAIQQAAGDPDLENPVVLVENSPRCKKNRQGEKVLPNGTVWLPQLLLLCTSVKLL 240

                 ....*...
gi 186478055 244 QRKAIHVD 251
Cdd:cd01853  241 SEANILLD 248
AIG1 pfam04548
AIG1 family; Arabidopsis protein AIG1 appears to be involved in plant resistance to bacteria.
38-231 3.73e-42

AIG1 family; Arabidopsis protein AIG1 appears to be involved in plant resistance to bacteria.


Pssm-ID: 398307 [Multi-domain]  Cd Length: 200  Bit Score: 143.90  E-value: 3.73e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186478055   38 TVLVLGKGGVGKSSTVNSLIGEQVVRvSPFQAEGL--RPVMVSRTMGGFTINIIDTPGLVEAGYVNHQAL-ELIKGFLVN 114
Cdd:pfam04548   2 RIVLVGKTGNGKSATGNSILGRKAFE-SKLRAQGVtkTCQLVSRTWDGRIINVIDTPGLFDLSVSNDFISkEIIRCLLLA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186478055  115 RT-IDVLLYVdrLDVYRVDELDKQVVIAITQTFGKEIWCKTLLVLTHAQFSPPDELsyETFSSKRS-DSLLKTIRAGSKM 192
Cdd:pfam04548  81 EPgPHAVLLV--LSLGRFTEEEEQALRTLQELFGSKILDYMIVVFTRKDDLEDDSL--DDYLSDGCpEFLKEVLRTADGE 156
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 186478055  193 RKQEFED---SAIAVVYAENSGRCSKNDKDEKALPNGEAWIP 231
Cdd:pfam04548 157 EKEEQVQqllALVEAIVKENGGKPYTNDLYEKIKEEGERLRE 198
YeeP COG3596
Predicted GTPase [General function prediction only];
11-206 1.24e-12

Predicted GTPase [General function prediction only];


Pssm-ID: 442815 [Multi-domain]  Cd Length: 318  Bit Score: 67.10  E-value: 1.24e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186478055  11 FQQFPAATQEKLIEffgKLKQKDMNSMT--VLVLGKGGVGKSSTVNSLIGEQVVRVSpfqaeGLRPV------MVSRTMG 82
Cdd:COG3596   15 LKRLPQVLRELLAE---ALERLLVELPPpvIALVGKTGAGKSSLINALFGAEVAEVG-----VGRPCtreiqrYRLESDG 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186478055  83 GFTINIIDTPGLVEAGYvNHQALELIKGFLvnRTIDVLLYV-DRLDVYRvdELDKQVVIAITQTFGKEiwcKTLLVLTHA 161
Cdd:COG3596   87 LPGLVLLDTPGLGEVNE-RDREYRELRELL--PEADLILWVvKADDRAL--ATDEEFLQALRAQYPDP---PVLVVLTQV 158
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 186478055 162 -QFSPPDELSYETfsSKRSDSLLKTIRAGSKMRKQEFEDSAIAVVY 206
Cdd:COG3596  159 dRLEPEREWDPPY--NWPSPPKEQNIRRALEAIAEQLGVPIDRVIP 202
PRK01889 PRK01889
GTPase RsgA; Reviewed
38-96 9.15e-05

GTPase RsgA; Reviewed


Pssm-ID: 234988 [Multi-domain]  Cd Length: 356  Bit Score: 43.38  E-value: 9.15e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 186478055  38 TVLVLGKGGVGKSSTVNSLIGEQVVRVSPFQAE---GlRPVMVSRTM----GGFTinIIDTPGLVE 96
Cdd:PRK01889 197 TVALLGSSGVGKSTLVNALLGEEVQKTGAVREDdskG-RHTTTHRELhplpSGGL--LIDTPGMRE 259
 
Name Accession Description Interval E-value
3a0901s02IAP34 TIGR00991
GTP-binding protein (Chloroplast Envelope Protein Translocase); [Transport and binding ...
1-296 8.08e-156

GTP-binding protein (Chloroplast Envelope Protein Translocase); [Transport and binding proteins, Nucleosides, purines and pyrimidines]


Pssm-ID: 130064  Cd Length: 313  Bit Score: 437.41  E-value: 8.08e-156
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186478055    1 MGSL--VREWVGFQQFPAATQEKLIEFFGKLKQKDMNSMTVLVLGKGGVGKSSTVNSLIGEQVVRVSPFQAEGLRPVMVS 78
Cdd:TIGR00991   1 MASPqtPREWVGIQQFPPATQTKLLELLGKLKEEDVSSLTILVMGKGGVGKSSTVNSIIGERIATVSAFQSEGLRPMMVS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186478055   79 RTMGGFTINIIDTPGLVEAGYVNHQALELIKGFLVNRTIDVLLYVDRLDVYRVDELDKQVVIAITQTFGKEIWCKTLLVL 158
Cdd:TIGR00991  81 RTRAGFTLNIIDTPGLIEGGYINDQAVNIIKRFLLGKTIDVLLYVDRLDAYRVDTLDGQVIRAITDSFGKDIWRKSLVVL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186478055  159 THAQFSPPDELSYETFSSKRSDSLLKTIRAGSKMRKQEFEDSAIAVVYAENSGRCSKNDKDEKALPNGEAWIPNLVKAIT 238
Cdd:TIGR00991 161 THAQFSPPDGLEYNDFFSKRSEALLRVIHSGAGLKKRDYQDFPIPVALVENSGRCKKNESDEKILPDGTPWIPKLMKEIT 240
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 186478055  239 DVATNQRKAIHVDKKMVDGSYSDDKGKKLIPLIIGAQYLIV-KMIQGAIRNDIKTSGKP 296
Cdd:TIGR00991 241 EVISNGSKPIHVDKKLIDGPNPNNRGKMFIPLIFAVQYLLVvKPIRRAIHADIANEKKD 299
Toc34_like cd01853
Translocon at the Outer-envelope membrane of Chloroplasts 34-like (Toc34-like); The Toc34-like ...
6-251 3.40e-135

Translocon at the Outer-envelope membrane of Chloroplasts 34-like (Toc34-like); The Toc34-like (Translocon at the Outer-envelope membrane of Chloroplasts) family contains several Toc proteins, including Toc34, Toc33, Toc120, Toc159, Toc86, Toc125, and Toc90. The Toc complex at the outer envelope membrane of chloroplasts is a molecular machine of ~500 kDa that contains a single Toc159 protein, four Toc75 molecules, and four or five copies of Toc34. Toc64 and Toc12 are associated with the translocon, but do not appear to be part of the core complex. The Toc translocon initiates the import of nuclear-encoded preproteins from the cytosol into the organelle. Toc34 and Toc159 are both GTPases, while Toc75 is a beta-barrel integral membrane protein. Toc159 is equally distributed between a soluble cytoplasmic form and a membrane-inserted form, suggesting that assembly of the Toc complex is dynamic. Toc34 and Toc75 act sequentially to mediate docking and insertion of Toc159 resulting in assembly of the functional translocon.


Pssm-ID: 206652  Cd Length: 248  Bit Score: 382.44  E-value: 3.40e-135
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186478055   6 REWVGFQQFPAATQEKLIEFFGKLKQKDMNSMTVLVLGKGGVGKSSTVNSLIGEQVVRVSPFQAEGLRPVMVSRTMGGFT 85
Cdd:cd01853    1 REWVGFQFFPDATQTKLHELEAKLKKELDFSLTILVLGKTGVGKSSTINSIFGERKVSVSAFQSETLRPREVSRTVDGFK 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186478055  86 INIIDTPGLVEA--GYVNHQALELIKGFLVNRTIDVLLYVDRLDVYRVDELDKQVVIAITQTFGKEIWCKTLLVLTHAQF 163
Cdd:cd01853   81 LNIIDTPGLLESqdQRVNRKILSIIKRFLKKKTIDVVLYVDRLDMYRVDNLDVPLLRAITDSFGPSIWRNAIVVLTHAQS 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186478055 164 SPPDELSYETFSSKRSDSLLKTIRAGSKMRKQEFEDSAIAVVYAENSGRCSKNDKDEKALPNGEAWIPNLVKAITDVATN 243
Cdd:cd01853  161 SPPDGPNGTPFSYDRFVAQRKHIVQQAIQQAAGDPDLENPVVLVENSPRCKKNRQGEKVLPNGTVWLPQLLLLCTSVKLL 240

                 ....*...
gi 186478055 244 QRKAIHVD 251
Cdd:cd01853  241 SEANILLD 248
AIG1 pfam04548
AIG1 family; Arabidopsis protein AIG1 appears to be involved in plant resistance to bacteria.
38-231 3.73e-42

AIG1 family; Arabidopsis protein AIG1 appears to be involved in plant resistance to bacteria.


Pssm-ID: 398307 [Multi-domain]  Cd Length: 200  Bit Score: 143.90  E-value: 3.73e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186478055   38 TVLVLGKGGVGKSSTVNSLIGEQVVRvSPFQAEGL--RPVMVSRTMGGFTINIIDTPGLVEAGYVNHQAL-ELIKGFLVN 114
Cdd:pfam04548   2 RIVLVGKTGNGKSATGNSILGRKAFE-SKLRAQGVtkTCQLVSRTWDGRIINVIDTPGLFDLSVSNDFISkEIIRCLLLA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186478055  115 RT-IDVLLYVdrLDVYRVDELDKQVVIAITQTFGKEIWCKTLLVLTHAQFSPPDELsyETFSSKRS-DSLLKTIRAGSKM 192
Cdd:pfam04548  81 EPgPHAVLLV--LSLGRFTEEEEQALRTLQELFGSKILDYMIVVFTRKDDLEDDSL--DDYLSDGCpEFLKEVLRTADGE 156
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 186478055  193 RKQEFED---SAIAVVYAENSGRCSKNDKDEKALPNGEAWIP 231
Cdd:pfam04548 157 EKEEQVQqllALVEAIVKENGGKPYTNDLYEKIKEEGERLRE 198
3a0901s04IAP86 TIGR00993
chloroplast protein import component Toc86/159, G and M domains; The long precursor of the 86K ...
36-234 1.57e-37

chloroplast protein import component Toc86/159, G and M domains; The long precursor of the 86K protein originally described is proposed to have three domains. The N-terminal A-domain is acidic, repetitive, weakly conserved, readily removed by proteolysis during chloroplast isolation, and not required for protein translocation. The other domains are designated G (GTPase) and M (membrane anchor); this family includes most of the G domain and all of M. [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273381 [Multi-domain]  Cd Length: 763  Bit Score: 141.24  E-value: 1.57e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186478055   36 SMTVLVLGKGGVGKSSTVNSLIGEQVVRVSPFQAEGLRPVMVSRTMGGFTINIIDTPGLVEAGY---VNHQALELIKGFL 112
Cdd:TIGR00993 118 SLNILVLGKSGVGKSATINSIFGEVKFSTDAFGMGTTSVQEIEGLVQGVKIRVIDTPGLKSSASdqsKNEKILSSVKKFI 197
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186478055  113 VNRTIDVLLYVDRLDVYRVDELDKQVVIAITQTFGKEIWCKTLLVLTHAQFSPPDE-----LSYETFSSKRSDSLLKTIR 187
Cdd:TIGR00993 198 KKNPPDIVLYVDRLDMQTRDSNDLPLLRTITDVLGPSIWFNAIVTLTHAASAPPDGpngtpLSYDVFVAQRSHIVQQAIG 277
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 186478055  188 -AGSKMRKQEfEDSAIAVVYAENSGRCSKNDKDEKALPNGEAWIPNLV 234
Cdd:TIGR00993 278 qAVGDLRLMN-PNLMNPVSLVENHPACRKNRAGQKVLPNGQVWKPHLL 324
Ras_like_GTPase cd00882
Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Ras-like ...
40-173 4.70e-14

Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras, Rho, Rab, and Sar1/Arf families. This superfamily also includes proteins like the GTP translation factors, Era-like GTPases, and G-alpha chain of the heterotrimeric G proteins. Members of the Ras superfamily regulate a wide variety of cellular functions: the Ras family regulates gene expression, the Rho family regulates cytoskeletal reorganization and gene expression, the Rab and Sar1/Arf families regulate vesicle trafficking, and the Ran family regulates nucleocytoplasmic transport and microtubule organization. The GTP translation factor family regulates initiation, elongation, termination, and release in translation, and the Era-like GTPase family regulates cell division, sporulation, and DNA replication. Members of the Ras superfamily are identified by the GTP binding site, which is made up of five characteristic sequence motifs, and the switch I and switch II regions.


Pssm-ID: 206648 [Multi-domain]  Cd Length: 161  Bit Score: 68.64  E-value: 4.70e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186478055  40 LVLGKGGVGKSSTVNSLIGEQVVRVSPFQAEGLRPVMVSRTM--GGFTINIIDTPGLVEAGYvnHQALELIKGFLvnRTI 117
Cdd:cd00882    1 VVVGRGGVGKSSLLNALLGGEVGEVSDVPGTTRDPDVYVKELdkGKVKLVLVDTPGLDEFGG--LGREELARLLL--RGA 76
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 186478055 118 DVLLYVDRLDVYRVDELDKQVVIAITQTFGKEIwcktLLVLTHAQFSPPDELSYET 173
Cdd:cd00882   77 DLILLVVDSTDRESEEDAKLLILRRLRKEGIPI----ILVGNKIDLLEEREVEELL 128
YeeP COG3596
Predicted GTPase [General function prediction only];
11-206 1.24e-12

Predicted GTPase [General function prediction only];


Pssm-ID: 442815 [Multi-domain]  Cd Length: 318  Bit Score: 67.10  E-value: 1.24e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186478055  11 FQQFPAATQEKLIEffgKLKQKDMNSMT--VLVLGKGGVGKSSTVNSLIGEQVVRVSpfqaeGLRPV------MVSRTMG 82
Cdd:COG3596   15 LKRLPQVLRELLAE---ALERLLVELPPpvIALVGKTGAGKSSLINALFGAEVAEVG-----VGRPCtreiqrYRLESDG 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186478055  83 GFTINIIDTPGLVEAGYvNHQALELIKGFLvnRTIDVLLYV-DRLDVYRvdELDKQVVIAITQTFGKEiwcKTLLVLTHA 161
Cdd:COG3596   87 LPGLVLLDTPGLGEVNE-RDREYRELRELL--PEADLILWVvKADDRAL--ATDEEFLQALRAQYPDP---PVLVVLTQV 158
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 186478055 162 -QFSPPDELSYETfsSKRSDSLLKTIRAGSKMRKQEFEDSAIAVVY 206
Cdd:COG3596  159 dRLEPEREWDPPY--NWPSPPKEQNIRRALEAIAEQLGVPIDRVIP 202
AIG1 cd01852
AvrRpt2-Induced Gene 1 (AIG1); This group represents Arabidoposis protein AIG1 ...
37-186 2.51e-12

AvrRpt2-Induced Gene 1 (AIG1); This group represents Arabidoposis protein AIG1 (avrRpt2-induced gene 1) that appears to be involved in plant resistance to bacteria. The Arabidopsis disease resistance gene RPS2 is involved in recognition of bacterial pathogens carrying the avirulence gene avrRpt2. AIG1 exhibits RPS2- and avrRpt1-dependent induction early after infection with Pseudomonas syringae carrying avrRpt2. This subfamily also includes IAN-4 protein, which has GTP-binding activity and shares sequence homology with a novel family of putative GTP-binding proteins: the immuno-associated nucleotide (IAN) family. The evolutionary conservation of the IAN family provides a unique example of a plant pathogen response gene conserved in animals. The IAN/IMAP subfamily has been proposed to regulate apoptosis in vertebrates and angiosperm plants, particularly in relation to cancer, diabetes, and infections. The human IAN genes were renamed GIMAP (GTPase of the immunity associated proteins).


Pssm-ID: 206651 [Multi-domain]  Cd Length: 201  Bit Score: 64.48  E-value: 2.51e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186478055  37 MTVLVLGKGGVGKSSTVNSLIGEQVVRvSPFQAEGL--RPVMVSRTMGGFTINIIDTPGLVEAGYVNHQ-ALELIKGF-L 112
Cdd:cd01852    1 LRLVLVGKTGNGKSATGNTILGRKVFE-SKLSASGVtkTCQKESAVWDGRRVNVIDTPGLFDTSVSPEQlSKEIIRCLsL 79
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 186478055 113 VNRTIDVLLYVDRLDvyRVDELDKQVVIAITQTFGKEIWCKTLLVLTHAqfsppDELSYETFSS--KRSDSLLKTI 186
Cdd:cd01852   80 SAPGPHAFLLVVPLG--RFTEEEEQAVEELQELFGEKVLDHTIVLFTRG-----DDLEGGSLEDylEDSCEALKRL 148
MMR_HSR1 pfam01926
50S ribosome-binding GTPase; The full-length GTPase protein is required for the complete ...
38-159 1.04e-10

50S ribosome-binding GTPase; The full-length GTPase protein is required for the complete activity of the protein of interacting with the 50S ribosome and binding of both adenine and guanine nucleotides, with a preference for guanine nucleotide.


Pssm-ID: 460387 [Multi-domain]  Cd Length: 113  Bit Score: 58.01  E-value: 1.04e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186478055   38 TVLVLGKGGVGKSSTVNSLIGEqVVRVSPFQAEGLRPVMVSRTMGGFTINIIDTPGLVEAgyvNHQALELIKGFLVNRTI 117
Cdd:pfam01926   1 RVALVGRPNVGKSTLINALTGA-KAIVSDYPGTTRDPNEGRLELKGKQIILVDTPGLIEG---ASEGEGLGRAFLAIIEA 76
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 186478055  118 DVLLYV-DRLDVYrvDELDKQVViaitqTFGKEIWCKTLLVLT 159
Cdd:pfam01926  77 DLILFVvDSEEGI--TPLDEELL-----ELLRENKKPIILVLN 112
Era_like cd00880
E. coli Ras-like protein (Era)-like GTPase; The Era (E. coli Ras-like protein)-like family ...
41-133 5.52e-08

E. coli Ras-like protein (Era)-like GTPase; The Era (E. coli Ras-like protein)-like family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngB), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs), to the exclusion of other GTPases. TrmE is ubiquitous in bacteria and is a widespread mitochondrial protein in eukaryotes, but is absent from archaea. The yeast member of TrmE family, MSS1, is involved in mitochondrial translation; bacterial members are often present in translation-related operons. FeoB represents an unusual adaptation of GTPases for high-affinity iron (II) transport. YihA (EngB) family of GTPases is typified by the E. coli YihA, which is an essential protein involved in cell division control. Era is characterized by a distinct derivative of the KH domain (the pseudo-KH domain) which is located C-terminal to the GTPase domain. EngA and its orthologs are composed of two GTPase domains and, since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that an ancient gene duplication, rather than a fusion of evolutionarily distinct GTPases, gave rise to this family.


Pssm-ID: 206646 [Multi-domain]  Cd Length: 161  Bit Score: 51.48  E-value: 5.52e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186478055  41 VLGKGGVGKSSTVNSLIGEQVVRVSPFQAEGLRPvmVSRTM---GGFTINIIDTPGLVEAGYV----NHQALELIKGflv 113
Cdd:cd00880    2 IFGRPNVGKSSLLNALLGQNVGIVSPIPGTTRDP--VRKEWellPLGPVVLIDTPGLDEEGGLgrerVEEARQVADR--- 76
                         90       100
                 ....*....|....*....|
gi 186478055 114 nrtIDVLLYVDRLDVYRVDE 133
Cdd:cd00880   77 ---ADLVLLVVDSDLTPVEE 93
Gem1 COG1100
GTPase SAR1 family domain [General function prediction only];
34-190 2.20e-07

GTPase SAR1 family domain [General function prediction only];


Pssm-ID: 440717 [Multi-domain]  Cd Length: 177  Bit Score: 49.98  E-value: 2.20e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186478055  34 MNSMTVLVLGKGGVGKSSTVNSLIGEQvvrVSPFQAEGLRPVMVSRTM-----GGFTINIIDTPGLVEagyvNHQALELI 108
Cdd:COG1100    1 MGEKKIVVVGTGGVGKTSLVNRLVGDI---FSLEKYLSTNGVTIDKKElkldgLDVDLVIWDTPGQDE----FRETRQFY 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186478055 109 KGFLVNRtiDVLLYVdrLDVYRVDELdKQVVIAITQTFGKEIWCKTLLVLTHAQFSPPDEL-SYETFSSKRSDSLLKTIR 187
Cdd:COG1100   74 ARQLTGA--SLYLFV--VDGTREETL-QSLYELLESLRRLGKKSPIILVLNKIDLYDEEEIeDEERLKEALSEDNIVEVV 148

                 ...
gi 186478055 188 AGS 190
Cdd:COG1100  149 ATS 151
PRK01889 PRK01889
GTPase RsgA; Reviewed
38-96 9.15e-05

GTPase RsgA; Reviewed


Pssm-ID: 234988 [Multi-domain]  Cd Length: 356  Bit Score: 43.38  E-value: 9.15e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 186478055  38 TVLVLGKGGVGKSSTVNSLIGEQVVRVSPFQAE---GlRPVMVSRTM----GGFTinIIDTPGLVE 96
Cdd:PRK01889 197 TVALLGSSGVGKSTLVNALLGEEVQKTGAVREDdskG-RHTTTHRELhplpSGGL--LIDTPGMRE 259
DLP_2 cd09912
Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; The ...
37-188 1.19e-04

Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; The dynamin family of large mechanochemical GTPases includes the classical dynamins and dynamin-like proteins (DLPs) that are found throughout the Eukarya. This family also includes bacterial DLPs. These proteins catalyze membrane fission during clathrin-mediated endocytosis. Dynamin consists of five domains; an N-terminal G domain that binds and hydrolyzes GTP, a middle domain (MD) involved in self-assembly and oligomerization, a pleckstrin homology (PH) domain responsible for interactions with the plasma membrane, GED, which is also involved in self-assembly, and a proline arginine rich domain (PRD) that interacts with SH3 domains on accessory proteins. To date, three vertebrate dynamin genes have been identified; dynamin 1, which is brain specific, mediates uptake of synaptic vesicles in presynaptic terminals; dynamin-2 is expressed ubiquitously and similarly participates in membrane fission; mutations in the MD, PH and GED domains of dynamin 2 have been linked to human diseases such as Charcot-Marie-Tooth peripheral neuropathy and rare forms of centronuclear myopathy. Dynamin 3 participates in megakaryocyte progenitor amplification, and is also involved in cytoplasmic enlargement and the formation of the demarcation membrane system. This family also includes mitofusins (MFN1 and MFN2 in mammals) that are involved in mitochondrial fusion. Dynamin oligomerizes into helical structures around the neck of budding vesicles in a GTP hydrolysis-dependent manner.


Pssm-ID: 206739 [Multi-domain]  Cd Length: 180  Bit Score: 42.15  E-value: 1.19e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186478055  37 MTVLVLGKGGVGKSSTVNSLIGEQV--VRVSPFQAeglRPVMVSRTMGGfTINIIDTPGLvEAGYVNHQalELIKGFLvn 114
Cdd:cd09912    1 FLLAVVGEFSAGKSTLLNALLGEEVlpTGVTPTTA---VITVLRYGLLK-GVVLVDTPGL-NSTIEHHT--EITESFL-- 71
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 186478055 115 RTIDVLLYVdrLDVYRV-DELDKQVVIAITQTFGKEIwcktLLVLTHAQFSPPDELSYETFSSKRSDSLLKTIRA 188
Cdd:cd09912   72 PRADAVIFV--LSADQPlTESEREFLKEILKWSGKKI----FFVLNKIDLLSEEELEEVLEYSREELGVLELGGG 140
CDC3 COG5019
Septin family protein [Cell cycle control, cell division, chromosome partitioning, ...
38-93 1.58e-04

Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 227352 [Multi-domain]  Cd Length: 373  Bit Score: 42.70  E-value: 1.58e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 186478055  38 TVLVLGKGGVGKSSTVNSLIGEQVVR---VSPFQAEGLRPVMVSRTM------GGF--TINIIDTPG 93
Cdd:COG5019   25 TIMVVGESGLGKTTFINTLFGTSLVDeteIDDIRAEGTSPTLEIKITkaeleeDGFhlNLTVIDTPG 91
RsgA COG1162
Ribosome biogenesis GTPase RsgA [Translation, ribosomal structure and biogenesis];
38-111 1.89e-04

Ribosome biogenesis GTPase RsgA [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440776 [Multi-domain]  Cd Length: 300  Bit Score: 42.41  E-value: 1.89e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186478055  38 TVLVLGKGGVGKSSTVNSLIGEQVVRVSpfqaeGLRPVM-------VSRTM-----GGFtinIIDTPGLVEAGYVNHQAL 105
Cdd:COG1162  168 TSVLVGQSGVGKSTLINALLPDADLATG-----EISEKLgrgrhttTHAELyplpgGGW---LIDTPGFREFGLWHIEPE 239

                 ....*.
gi 186478055 106 ELIKGF 111
Cdd:COG1162  240 ELAHYF 245
HSR1_MMR1 cd01857
A circularly permuted subfamily of the Ras GTPases; Human HSR1 is localized to the human MHC ...
47-95 1.92e-04

A circularly permuted subfamily of the Ras GTPases; Human HSR1 is localized to the human MHC class I region and is highly homologous to a putative GTP-binding protein, MMR1 from mouse. These proteins represent a new subfamily of GTP-binding proteins that has only eukaryote members. This subfamily shows a circular permutation of the GTPase signature motifs so that the C-terminal strands 5, 6, and 7 (strand 6 contains the G4 box with sequence NKXD) are relocated to the N-terminus.


Pssm-ID: 206750 [Multi-domain]  Cd Length: 140  Bit Score: 40.68  E-value: 1.92e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 186478055  47 VGKSSTVNSLIGEQVVRVS--P-----FQAEGLRPvmvsrtmggfTINIIDTPGLV 95
Cdd:cd01857   93 VGKSSLINALVGSKKVSVSstPgktkhFQTIFLEP----------GITLCDCPGLV 138
YlqF_related_GTPase cd01849
Circularly permuted YlqF-related GTPases; These proteins are found in bacteria, eukaryotes, ...
28-94 2.29e-04

Circularly permuted YlqF-related GTPases; These proteins are found in bacteria, eukaryotes, and archaea. They all exhibit a circular permutation of the GTPase signature motifs so that the order of the conserved G box motifs is G4-G5-G1-G2-G3, with G4 and G5 being permuted from the C-terminal region of proteins in the Ras superfamily to the N-terminus of YlqF-related GTPases.


Pssm-ID: 206746 [Multi-domain]  Cd Length: 146  Bit Score: 40.45  E-value: 2.29e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 186478055  28 KLKQKDMNSMTVLVLGKGGVGKSSTVNSLIGEQVVRVSPFQAEGLRPVMVSRTmggFTINIIDTPGL 94
Cdd:cd01849   83 KLKLKYKKGIRVGVVGLPNVGKSSFINALLNKFKLKVGSIPGTTKLQQDVKLD---KEIYLYDTPGI 146
TIGR00157 TIGR00157
ribosome small subunit-dependent GTPase A; Members of this protein were designated YjeQ and ...
18-111 3.32e-04

ribosome small subunit-dependent GTPase A; Members of this protein were designated YjeQ and are now designated RsgA (ribosome small subunit-dependent GTPase A). The strongest motif in the alignment of these proteins is GXSGVGKS[ST], a classic P-loop for nucleotide binding. This protein has been shown to cleave GTP and remain bound to GDP. A role as a regulator of translation has been suggested. The Aquifex aeolicus ortholog is split into consecutive open reading frames. Consequently, this model was build in fragment mode (-f option). [Protein synthesis, Translation factors]


Pssm-ID: 272934 [Multi-domain]  Cd Length: 245  Bit Score: 41.25  E-value: 3.32e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186478055   18 TQEKLIEFFGKLKQKdmnsmTVLVLGKGGVGKSSTVN---SLIGEQVVRVSPFQAEG---LRPVMVSRTMGGFtinIIDT 91
Cdd:TIGR00157 107 NQDGLKELIEALQNR-----ISVFAGQSGVGKSSLINaldPSVKQQVNDISSKLGLGkhtTTHVELFHFHGGL---IADT 178
                          90       100
                  ....*....|....*....|
gi 186478055   92 PGLVEAGYVNHQALELIKGF 111
Cdd:TIGR00157 179 PGFNEFGLWHLEPEQLTQGF 198
YfjP cd11383
YfjP GTPase; The Era (E. coli Ras-like protein)-like YfjP subfamily includes several ...
40-161 3.95e-04

YfjP GTPase; The Era (E. coli Ras-like protein)-like YfjP subfamily includes several uncharacterized bacterial GTPases that are similar to Era. They generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs), to the exclusion of other GTPases. Era is characterized by a distinct derivative of the KH domain (the pseudo-KH domain) which is located C-terminal to the GTPase domain.


Pssm-ID: 206743 [Multi-domain]  Cd Length: 140  Bit Score: 40.02  E-value: 3.95e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186478055  40 LVLGKGGVGKSSTVNSLIGEQVVRVSPFQAEGLRPVMVSRTMGGFTINIIDTPGLVEAGYVNHQALELIKGFLvnRTIDV 119
Cdd:cd11383    1 GLMGKTGAGKSSLCNALFGTEVAAVGDRRPTTRAAQAYVWQTGGDGLVLLDLPGVGERGRRDREYEELYRRLL--PEADL 78
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 186478055 120 LLYVDRLDVYrVDELDKQVVIAITQTFGKeiwcKTLLVLTHA 161
Cdd:cd11383   79 VLWLLDADDR-ALAADHDFYLLPLAGHDA----PLLFVLNQV 115
YjeQ_EngC cd01854
Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; ...
16-93 4.19e-04

Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; YjeQ (YloQ in Bacillus subtilis) is a ribosomal small subunit-dependent GTPase; hence also known as RsgA. YjeQ is a late-stage ribosomal biogenesis factor involved in the 30S subunit maturation, and it represents a protein family whose members are broadly conserved in bacteria and have been shown to be essential to the growth of E. coli and B. subtilis. Proteins of the YjeQ family contain all sequence motifs typical of the vast class of P-loop-containing GTPases, but show a circular permutation, with a G4-G1-G3 pattern of motifs as opposed to the regular G1-G3-G4 pattern seen in most GTPases. All YjeQ family proteins display a unique domain architecture, which includes an N-terminal OB-fold RNA-binding domain, the central permuted GTPase domain, and a zinc knuckle-like C-terminal cysteine domain.


Pssm-ID: 206747 [Multi-domain]  Cd Length: 211  Bit Score: 40.84  E-value: 4.19e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186478055  16 AATQEKLIEFFGKLKQKdmnsmTVLVLGKGGVGKSSTVNSLIGEQVVRVSPfqaeglrpvmVS------------RTM-- 81
Cdd:cd01854   70 AKTGEGLDELRELLKGK-----TSVLVGQSGVGKSTLLNALLPELVLATGE----------ISeklgrgrhttthRELfp 134
                         90
                 ....*....|....*
gi 186478055  82 ---GGFtinIIDTPG 93
Cdd:cd01854  135 lpgGGL---IIDTPG 146
small_GTP TIGR00231
small GTP-binding protein domain; Proteins with a small GTP-binding domain recognized by this ...
37-188 1.28e-03

small GTP-binding protein domain; Proteins with a small GTP-binding domain recognized by this model include Ras, RhoA, Rab11, translation elongation factor G, translation initiation factor IF-2, tetratcycline resistance protein TetM, CDC42, Era, ADP-ribosylation factors, tdhF, and many others. In some proteins the domain occurs more than once.This model recognizes a large number of small GTP-binding proteins and related domains in larger proteins. Note that the alpha chains of heterotrimeric G proteins are larger proteins in which the NKXD motif is separated from the GxxxxGK[ST] motif (P-loop) by a long insert and are not easily detected by this model. [Unknown function, General]


Pssm-ID: 272973 [Multi-domain]  Cd Length: 162  Bit Score: 38.89  E-value: 1.28e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186478055   37 MTVLVLGKGGVGKSSTVNSLIGEQVVRVS--PFQAEGLRPVMVSRTMGGFTINIIDTPGLVE----AGYVNHQALELIKG 110
Cdd:TIGR00231   2 IKIVIVGHPNVGKSTLLNSLLGNKGSITEyyPGTTRNYVTTVIEEDGKTYKFNLLDTAGQEDydaiRRLYYPQVERSLRV 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186478055  111 F-LVNRTIDVLLYVDRLDVYRVDELDKQVVIAItqtFGKEIWCKTLLVLTHAQFSPPdELSYETFS------SKRSDSLL 183
Cdd:TIGR00231  82 FdIVILVLDVEEILEKQTKEIIHHADSGVPIIL---VGNKIDLKDADLKTHVASEFA-KLNGEPIIplsaetGKNIDSAF 157

                  ....*
gi 186478055  184 KTIRA 188
Cdd:TIGR00231 158 KIVEA 162
RsgA_GTPase pfam03193
RsgA GTPase; RsgA (also known as EngC and YjeQ) represents a protein family whose members are ...
38-93 2.18e-03

RsgA GTPase; RsgA (also known as EngC and YjeQ) represents a protein family whose members are broadly conserved in bacteria and are indispensable for growth. The GTPase domain of RsgA is very similar to several P-loop GTPases, but differs in having a circular permutation of the GTPase structure described by a G4-G1-G3 pattern.


Pssm-ID: 427191 [Multi-domain]  Cd Length: 174  Bit Score: 38.29  E-value: 2.18e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 186478055   38 TVLVLGKGGVGKSSTVNSLIGEQVVRVSPF-QAEGL------RPVMVSRTMGGFtinIIDTPG 93
Cdd:pfam03193 108 TTVLAGQSGVGKSTLLNALLPELDLRTGEIsEKLGRgrhtttHVELFPLPGGGL---LIDTPG 167
EngA2 cd01895
EngA2 GTPase contains the second domain of EngA; This EngA2 subfamily CD represents the second ...
35-128 3.72e-03

EngA2 GTPase contains the second domain of EngA; This EngA2 subfamily CD represents the second GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that an ancient gene duplication, rather than a fusion of evolutionarily distinct GTPases, gave rise to this family. Although the exact function of these proteins has not been elucidated, studies have revealed that the E. coli EngA homolog, Der, and Neisseria gonorrhoeae EngA are essential for cell viability. A recent report suggests that E. coli Der functions in ribosome assembly and stability.


Pssm-ID: 206682 [Multi-domain]  Cd Length: 174  Bit Score: 37.41  E-value: 3.72e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186478055  35 NSMTVLVLGKGGVGKSSTVNSLIGEQVVRVSPfQAEGLR-PVMVSRTMGGFTINIIDTPGLVEAGYVNhQALELikgFLV 113
Cdd:cd01895    1 DPIKIAIIGRPNVGKSSLLNALLGEERVIVSD-IAGTTRdSIDVPFEYDGQKYTLIDTAGIRKKGKVT-EGIEK---YSV 75
                         90
                 ....*....|....*
gi 186478055 114 NRTIDVLlyvDRLDV 128
Cdd:cd01895   76 LRTLKAI---ERADV 87
CDC_Septin cd01850
CDC/Septin GTPase family; Septins are a conserved family of GTP-binding proteins associated ...
37-93 5.98e-03

CDC/Septin GTPase family; Septins are a conserved family of GTP-binding proteins associated with diverse processes in dividing and non-dividing cells. They were first discovered in the budding yeast S. cerevisiae as a set of genes (CDC3, CDC10, CDC11 and CDC12) required for normal bud morphology. Septins are also present in metazoan cells, where they are required for cytokinesis in some systems, and implicated in a variety of other processes involving organization of the cell cortex and exocytosis. In humans, 12 septin genes generate dozens of polypeptides, many of which comprise heterooligomeric complexes. Since septin mutants are commonly defective in cytokinesis and formation of the neck formation of the neck filaments/septin rings, septins have been considered to be the primary constituents of the neck filaments. Septins belong to the GTPase superfamily for their conserved GTPase motifs and enzymatic activities.


Pssm-ID: 206649  Cd Length: 275  Bit Score: 37.53  E-value: 5.98e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 186478055  37 MTVLVLGKGGVGKSSTVNSLIGEQVVRVSPFQAEGLRP----VMVSRTM----GGFTI--NIIDTPG 93
Cdd:cd01850    5 FNIMVVGESGLGKSTFINTLFGTKLYPSKYPPAPGEHItktvEIKISKAeleeNGVKLklTVIDTPG 71
Obg_like cd01881
Obg-like family of GTPases consist of five subfamilies: Obg, DRG, YyaF/YchF, Ygr210, and NOG1; ...
41-123 7.88e-03

Obg-like family of GTPases consist of five subfamilies: Obg, DRG, YyaF/YchF, Ygr210, and NOG1; The Obg-like subfamily consists of five well-delimited, ancient subfamilies, namely Obg, DRG, YyaF/YchF, Ygr210, and NOG1. Four of these groups (Obg, DRG, YyaF/YchF, and Ygr210) are characterized by a distinct glycine-rich motif immediately following the Walker B motif (G3 box). Obg/CgtA is an essential gene that is involved in the initiation of sporulation and DNA replication in the bacteria Caulobacter and Bacillus, but its exact molecular role is unknown. Furthermore, several OBG family members possess a C-terminal RNA-binding domain, the TGS domain, which is also present in threonyl-tRNA synthetase and in bacterial guanosine polyphosphatase SpoT. Nog1 is a nucleolar protein that might function in ribosome assembly. The DRG and Nog1 subfamilies are ubiquitous in archaea and eukaryotes, the Ygr210 subfamily is present in archaea and fungi, and the Obg and YyaF/YchF subfamilies are ubiquitous in bacteria and eukaryotes. The Obg/Nog1 and DRG subfamilies appear to form one major branch of the Obg family and the Ygr210 and YchF subfamilies form another branch. No GEFs, GAPs, or GDIs for Obg have been identified.


Pssm-ID: 206668 [Multi-domain]  Cd Length: 167  Bit Score: 36.60  E-value: 7.88e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186478055  41 VLGKGGVGKSSTVNSLIGEQVvRVSPFQAEGLRP-VMVSRTMGGFTINIIDTPGLVEAGyvnHQALELIKGFLVN-RTID 118
Cdd:cd01881    2 LVGLPNVGKSTLLSALTSAKV-EIASYPFTTLEPnVGVFEFGDGVDIQIIDLPGLLDGA---SEGRGLGEQILAHlYRSD 77

                 ....*
gi 186478055 119 VLLYV 123
Cdd:cd01881   78 LILHV 82
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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