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Conserved domains on  [gi|181339464|ref|NP_001116710|]
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plasma membrane calcium-transporting ATPase 2 [Danio rerio]

Protein Classification

plasma membrane calcium-transporting ATPase( domain architecture ID 13522140)

plasma membrane calcium-transporting ATPase functions to export Ca(2+) from cells and plays a role in regulating Ca(2+) signals following stimulus induction and in preventing calcium toxicity

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
ATPase-IIB_Ca super family cl36924
plasma-membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase ...
9-1096 0e+00

plasma-membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase responsible for translocating calcium ions across the plasma membrane of eukaryotes, out of the cell. In some organisms, this type of pump may also be found in vacuolar membranes. In humans and mice, at least, there are multiple isoforms of the PMCA pump with overlapping but not redundant functions. Accordingly, there are no human diseases linked to PMCA defects, although alterations of PMCA function do elicit physiological effects. The calcium P-type ATPases have been characterized as Type IIB based on a phylogenetic analysis which distinguishes this group from the Type IIA SERCA calcium pump. A separate analysis divides Type IIA into sub-types (SERCA and PMR1) which are represented by two corresponding models (TIGR01116 and TIGR01522). This model is well separated from those.


The actual alignment was detected with superfamily member TIGR01517:

Pssm-ID: 273668 [Multi-domain]  Cd Length: 956  Bit Score: 1297.44  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464     9 KNQRNDSNHEGGFGCSLMELRSLMELRGTEAV---VKIQEDYGGTEGLCQRLKTSPTEGLAGLATDLDKRKEVFGRNLIP 85
Cdd:TIGR01517    1 MESVRRRTSIRDNFTDGFDVGVSILTDLTDIFkkaMPLYEKLGGAEGIATKLKTDLNEGVRLSSSTLERREKVYGKNELP 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464    86 PKKPKTFLQLVWEALQDVTLIILEIAALISLGLSFYQP-PGEGNtdacgdakagaedeGESEAGWIEGAAILLSVVCVVL 164
Cdd:TIGR01517   81 EKPPKSFLQIVWAALSDQTLILLSVAAVVSLVLGLYVPsVGEDK--------------ADTETGWIEGVAILVSVILVVL 146
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   165 VTAFNDWSKEKQFRGLQsRIEQEQKFQVVRGGQVIQLPVADILVGDIAQIKYGDLLPADGVLIQGNDLKIDESSLTGESD 244
Cdd:TIGR01517  147 VTAVNDYKKELQFRQLN-REKSAQKIAVIRGGQEQQISIHDIVVGDIVSLSTGDVVPADGVFISGLSLEIDESSITGESD 225
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   245 HVRKAADKDPMLLSGTHVMEGSGRMVVTAVGVNSQSGIIFTLLgaggeeeekkekkgqaledghplpdcshpsshpiati 324
Cdd:TIGR01517  226 PIKKGPVQDPFLLSGTVVNEGSGRMLVTAVGVNSFGGKLMMEL------------------------------------- 268
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   325 atdgaasantpantslvngkmqdgnmennqtkvkkqdgaaamemqplksaeggeteekekkktSVSKKEKSVLQGKLTKL 404
Cdd:TIGR01517  269 ---------------------------------------------------------------RQAGEEETPLQEKLSEL 285
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   405 AVQIGKAGLVMSAITVIILVLYFAIDTFVRQKRPwltECTPIYIQYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKK 484
Cdd:TIGR01517  286 AGLIGKFGMGSAVLLFLVLSLRYVFRIIRGDGRF---EDTEEDAQTFLDHFIIAVTIVVVAVPEGLPLAVTIALAYSMKK 362
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   485 MMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTAVQVYVADVHYKTIPE--PTSLPSKTLDILVNAISLNSayttk 562
Cdd:TIGR01517  363 MMKDNNLVRHLAACETMGSATAICSDKTGTLTQNVMSVVQGYIGEQRFNVRDEivLRNLPAAVRNILVEGISLNS----- 437
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   563 ILPADKE-GGLPKQVGNKTECGFLGLVLDVKRDYQTIRNQIPEEKLYKVYTFNSVRKSMSTVIKLPDGSFRMYSKGASEI 641
Cdd:TIGR01517  438 SSEEVVDrGGKRAFIGSKTECALLDFGLLLLLQSRDVQEVRAEEKVVKIYPFNSERKFMSVVVKHSGGKYREFRKGASEI 517
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   642 ILKKCSRILSEVGEPRVFRPRDRDEmVKKVIEPMACDGLRTICVGYRDFPKDPEPNWEDENNiltDLTAICVVGIEDPVR 721
Cdd:TIGR01517  518 VLKPCRKRLDSNGEATPISEDDKDR-CADVIEPLASDALRTICLAYRDFAPEEFPRKDYPNK---GLTLIGVVGIKDPLR 593
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   722 PEVPDAIQKCQRAGITVRMVTGDNINTARAIAIKCGIIHPGEdfLCIDGKEFNRRIRNEkgeveqerIDKVWPKLRVLAR 801
Cdd:TIGR01517  594 PGVREAVQECQRAGITVRMVTGDNIDTAKAIARNCGILTFGG--LAMEGKEFRSLVYEE--------MDPILPKLRVLAR 663
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   802 SSPTDKHTLVKgiidsTLVDQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRN 881
Cdd:TIGR01517  664 SSPLDKQLLVL-----MLKDMGEVVAVTGDGTNDAPALKLADVGFSMGISGTEVAKEASDIILLDDNFASIVRAVKWGRN 738
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   882 VYDSISKFLQFQLTVNVVAVIVAFTGACIT--QDSPLKAVQMLWVNLIMDTFASLALATEPPTESLLMRKPYGRNKPLIS 959
Cdd:TIGR01517  739 VYDNIRKFLQFQLTVNVVAVILTFVGSCISssHTSPLTAVQLLWVNLIMDTLAALALATEPPTEALLDRKPIGRNAPLIS 818
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   960 STMTKNILGHGVYQLVIIFSLLFVGEQIFDIDSGRNAPlHSPPSEHYTIIFNTFVMMQLFNEINARKIHGERNVFDGIFR 1039
Cdd:TIGR01517  819 RSMWKNILGQAGYQLVVTFILLFAGGSIFDVSGPDEIT-SHQQGELNTIVFNTFVLLQLFNEINARKLYEGMNVFEGLFK 897
                         1050      1060      1070      1080      1090
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 181339464  1040 NPIFCSIVVGTFAIQIVIVQFGGKPFSCSPLDLEKWMWCVFLGMGELVWGQVISTIP 1096
Cdd:TIGR01517  898 NRIFVTIMGFTFGFQVIIVEFGGSFFSTVSLSIEQWIGCVLLGMLSLIFGVLLRLIP 954
ATP_Ca_trans_C pfam12424
Plasma membrane calcium transporter ATPase C terminal; This domain family is found in ...
1137-1183 5.73e-27

Plasma membrane calcium transporter ATPase C terminal; This domain family is found in eukaryotes, and is approximately 60 amino acids in length. The family is found in association with pfam00689, pfam00122, pfam00702, pfam00690. There is a conserved QTQ sequence motif. This family is the C terminal of a calcium transporting ATPase located in the plasma membrane.


:

Pssm-ID: 463575  Cd Length: 47  Bit Score: 104.02  E-value: 5.73e-27
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 181339464  1137 GQILWFRGLNRIQTQIRVVNAFRSSLYEGLEKPESRTSIHNFMTHPE 1183
Cdd:pfam12424    1 GQILWFRGLNRIQTQIRVVKAFQSSLREGIQKPYLRNSIHSFMSHPE 47
 
Name Accession Description Interval E-value
ATPase-IIB_Ca TIGR01517
plasma-membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase ...
9-1096 0e+00

plasma-membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase responsible for translocating calcium ions across the plasma membrane of eukaryotes, out of the cell. In some organisms, this type of pump may also be found in vacuolar membranes. In humans and mice, at least, there are multiple isoforms of the PMCA pump with overlapping but not redundant functions. Accordingly, there are no human diseases linked to PMCA defects, although alterations of PMCA function do elicit physiological effects. The calcium P-type ATPases have been characterized as Type IIB based on a phylogenetic analysis which distinguishes this group from the Type IIA SERCA calcium pump. A separate analysis divides Type IIA into sub-types (SERCA and PMR1) which are represented by two corresponding models (TIGR01116 and TIGR01522). This model is well separated from those.


Pssm-ID: 273668 [Multi-domain]  Cd Length: 956  Bit Score: 1297.44  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464     9 KNQRNDSNHEGGFGCSLMELRSLMELRGTEAV---VKIQEDYGGTEGLCQRLKTSPTEGLAGLATDLDKRKEVFGRNLIP 85
Cdd:TIGR01517    1 MESVRRRTSIRDNFTDGFDVGVSILTDLTDIFkkaMPLYEKLGGAEGIATKLKTDLNEGVRLSSSTLERREKVYGKNELP 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464    86 PKKPKTFLQLVWEALQDVTLIILEIAALISLGLSFYQP-PGEGNtdacgdakagaedeGESEAGWIEGAAILLSVVCVVL 164
Cdd:TIGR01517   81 EKPPKSFLQIVWAALSDQTLILLSVAAVVSLVLGLYVPsVGEDK--------------ADTETGWIEGVAILVSVILVVL 146
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   165 VTAFNDWSKEKQFRGLQsRIEQEQKFQVVRGGQVIQLPVADILVGDIAQIKYGDLLPADGVLIQGNDLKIDESSLTGESD 244
Cdd:TIGR01517  147 VTAVNDYKKELQFRQLN-REKSAQKIAVIRGGQEQQISIHDIVVGDIVSLSTGDVVPADGVFISGLSLEIDESSITGESD 225
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   245 HVRKAADKDPMLLSGTHVMEGSGRMVVTAVGVNSQSGIIFTLLgaggeeeekkekkgqaledghplpdcshpsshpiati 324
Cdd:TIGR01517  226 PIKKGPVQDPFLLSGTVVNEGSGRMLVTAVGVNSFGGKLMMEL------------------------------------- 268
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   325 atdgaasantpantslvngkmqdgnmennqtkvkkqdgaaamemqplksaeggeteekekkktSVSKKEKSVLQGKLTKL 404
Cdd:TIGR01517  269 ---------------------------------------------------------------RQAGEEETPLQEKLSEL 285
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   405 AVQIGKAGLVMSAITVIILVLYFAIDTFVRQKRPwltECTPIYIQYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKK 484
Cdd:TIGR01517  286 AGLIGKFGMGSAVLLFLVLSLRYVFRIIRGDGRF---EDTEEDAQTFLDHFIIAVTIVVVAVPEGLPLAVTIALAYSMKK 362
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   485 MMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTAVQVYVADVHYKTIPE--PTSLPSKTLDILVNAISLNSayttk 562
Cdd:TIGR01517  363 MMKDNNLVRHLAACETMGSATAICSDKTGTLTQNVMSVVQGYIGEQRFNVRDEivLRNLPAAVRNILVEGISLNS----- 437
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   563 ILPADKE-GGLPKQVGNKTECGFLGLVLDVKRDYQTIRNQIPEEKLYKVYTFNSVRKSMSTVIKLPDGSFRMYSKGASEI 641
Cdd:TIGR01517  438 SSEEVVDrGGKRAFIGSKTECALLDFGLLLLLQSRDVQEVRAEEKVVKIYPFNSERKFMSVVVKHSGGKYREFRKGASEI 517
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   642 ILKKCSRILSEVGEPRVFRPRDRDEmVKKVIEPMACDGLRTICVGYRDFPKDPEPNWEDENNiltDLTAICVVGIEDPVR 721
Cdd:TIGR01517  518 VLKPCRKRLDSNGEATPISEDDKDR-CADVIEPLASDALRTICLAYRDFAPEEFPRKDYPNK---GLTLIGVVGIKDPLR 593
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   722 PEVPDAIQKCQRAGITVRMVTGDNINTARAIAIKCGIIHPGEdfLCIDGKEFNRRIRNEkgeveqerIDKVWPKLRVLAR 801
Cdd:TIGR01517  594 PGVREAVQECQRAGITVRMVTGDNIDTAKAIARNCGILTFGG--LAMEGKEFRSLVYEE--------MDPILPKLRVLAR 663
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   802 SSPTDKHTLVKgiidsTLVDQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRN 881
Cdd:TIGR01517  664 SSPLDKQLLVL-----MLKDMGEVVAVTGDGTNDAPALKLADVGFSMGISGTEVAKEASDIILLDDNFASIVRAVKWGRN 738
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   882 VYDSISKFLQFQLTVNVVAVIVAFTGACIT--QDSPLKAVQMLWVNLIMDTFASLALATEPPTESLLMRKPYGRNKPLIS 959
Cdd:TIGR01517  739 VYDNIRKFLQFQLTVNVVAVILTFVGSCISssHTSPLTAVQLLWVNLIMDTLAALALATEPPTEALLDRKPIGRNAPLIS 818
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   960 STMTKNILGHGVYQLVIIFSLLFVGEQIFDIDSGRNAPlHSPPSEHYTIIFNTFVMMQLFNEINARKIHGERNVFDGIFR 1039
Cdd:TIGR01517  819 RSMWKNILGQAGYQLVVTFILLFAGGSIFDVSGPDEIT-SHQQGELNTIVFNTFVLLQLFNEINARKLYEGMNVFEGLFK 897
                         1050      1060      1070      1080      1090
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 181339464  1040 NPIFCSIVVGTFAIQIVIVQFGGKPFSCSPLDLEKWMWCVFLGMGELVWGQVISTIP 1096
Cdd:TIGR01517  898 NRIFVTIMGFTFGFQVIIVEFGGSFFSTVSLSIEQWIGCVLLGMLSLIFGVLLRLIP 954
P-type_ATPase_Ca_PMCA-like cd02081
animal plasma membrane Ca2(+)-ATPases (PMCA), similar to human ATP2B1-4/PMCA1-4, and related ...
72-962 0e+00

animal plasma membrane Ca2(+)-ATPases (PMCA), similar to human ATP2B1-4/PMCA1-4, and related Ca2(+)-ATPases including Saccharomyces cerevisiae vacuolar PMC1; Animal PMCAs function to export Ca(2+) from cells and play a role in regulating Ca(2+) signals following stimulus induction and in preventing calcium toxicity. Many PMCA pump variants exist due to alternative splicing of transcripts. PMCAs are regulated by the binding of calmodulin or by kinase-mediated phosphorylation. Saccharomyces cerevisiae vacuolar transporter Pmc1p facilitates the accumulation of Ca2+ into vacuoles. Pmc1p is not regulated by direct calmodulin binding but responds to the calmodulin/calcineurin-signaling pathway and is controlled by the transcription factor complex Tcn1p/Crz1p. Similarly, the expression of the gene for Dictyostelium discoideum Ca(2+)-ATPase PAT1, patA, is under the control of a calcineurin-dependent transcription factor. Plant vacuolar Ca(2+)-ATPases, are regulated by direct-calmodulin binding. Plant Ca(2+)-ATPases are present at various cellular locations including the plasma membrane, endoplasmic reticulum, chloroplast and vacuole. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319776 [Multi-domain]  Cd Length: 721  Bit Score: 1277.14  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   72 LDKRKEVFGRNLIPPKKPKTFLQLVWEALQDVTLIILEIAALISLGLSFYQPPGEGntdacgdakagaedegESEAGWIE 151
Cdd:cd02081     1 LEHRREVYGKNEIPPKPPKSFLQLVWEALQDPTLIILLIAAIVSLGLGFYTPFGEG----------------EGKTGWIE 64
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  152 GAAILLSVVCVVLVTAFNDWSKEKQFRGLQSRIEqEQKFQVVRGGQVIQLPVADILVGDIAQIKYGDLLPADGVLIQGND 231
Cdd:cd02081    65 GVAILVAVILVVLVTAGNDYQKEKQFRKLNSKKE-DQKVTVIRDGEVIQISVFDIVVGDIVQLKYGDLIPADGLLIEGND 143
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  232 LKIDESSLTGESDHVRKAAD---KDPMLLSGTHVMEGSGRMVVTAVGVNSQSGIIFTLLgaggeeeekkekkgqaledgh 308
Cdd:cd02081   144 LKIDESSLTGESDPIKKTPDnqiPDPFLLSGTKVLEGSGKMLVTAVGVNSQTGKIMTLL--------------------- 202
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  309 plpdcshpsshpiatiatdgaasantpantslvngkmqdgnmennqtkvkkqdgaaamemqplksaeggeteekekkktS 388
Cdd:cd02081   203 -------------------------------------------------------------------------------R 203
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  389 VSKKEKSVLQGKLTKLAVQIGKAGLVMSAITVIILVLYFAIDTFVRQKRPWltecTPIYIQYFVKFFIIGVTVLVVAVPE 468
Cdd:cd02081   204 AENEEKTPLQEKLTKLAVQIGKVGLIVAALTFIVLIIRFIIDGFVNDGKSF----SAEDLQEFVNFFIIAVTIIVVAVPE 279
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  469 GLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTAVQVYVadvhyktipeptslpsktldi 548
Cdd:cd02081   280 GLPLAVTLSLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTQNRMTVVQGYI--------------------- 338
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  549 lvnaislnsayttkilpadkegglpkqvGNKTECGFLGLVLDVKRDYQtIRNQIPEEKLYKVYTFNSVRKSMSTVIKLPD 628
Cdd:cd02081   339 ----------------------------GNKTECALLGFVLELGGDYR-YREKRPEEKVLKVYPFNSARKRMSTVVRLKD 389
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  629 GSFRMYSKGASEIILKKCSRILSEVGEpRVFRPRDRDEMVKKVIEPMACDGLRTICVGYRDFPKDPEP----NWEDENNI 704
Cdd:cd02081   390 GGYRLYVKGASEIVLKKCSYILNSDGE-VVFLTSEKKEEIKRVIEPMASDSLRTIGLAYRDFSPDEEPtaerDWDDEEDI 468
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  705 LTDLTAICVVGIEDPVRPEVPDAIQKCQRAGITVRMVTGDNINTARAIAIKCGIIHPGEDFLCIDGKEFNRRIRNEKGEV 784
Cdd:cd02081   469 ESDLTFIGIVGIKDPLRPEVPEAVAKCQRAGITVRMVTGDNINTARAIARECGILTEGEDGLVLEGKEFRELIDEEVGEV 548
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  785 EQERIDKVWPKLRVLARSSPTDKHTLVKGIIDStlvdqRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIIL 864
Cdd:cd02081   549 CQEKFDKIWPKLRVLARSSPEDKYTLVKGLKDS-----GEVVAVTGDGTNDAPALKKADVGFAMGIAGTEVAKEASDIIL 623
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  865 TDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTFASLALATEPPTES 944
Cdd:cd02081   624 LDDNFSSIVKAVMWGRNVYDSIRKFLQFQLTVNVVAVILAFIGAVVTKDSPLTAVQMLWVNLIMDTLAALALATEPPTED 703
                         890
                  ....*....|....*...
gi 181339464  945 LLMRKPYGRNKPLISSTM 962
Cdd:cd02081   704 LLKRKPYGRDKPLISRTM 721
MgtA COG0474
Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];
50-1092 0e+00

Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];


Pssm-ID: 440242 [Multi-domain]  Cd Length: 874  Bit Score: 660.26  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   50 TEGLCQRLKTSPtEGLAglATDLDKRKEVFGRNLIPPKKPKTFLQLVWEALQDVTLIILEIAALISLGLsfyqppgegnt 129
Cdd:COG0474    13 AEEVLAELGTSE-EGLS--SEEAARRLARYGPNELPEEKKRSLLRRFLEQFKNPLILILLAAAVISALL----------- 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  130 dacGDakagaedegeseagWIEGAAILLSVVCVVLVTAFNDWSKEKQFRGLQSRIEQEQKfqVVRGGQVIQLPVADILVG 209
Cdd:COG0474    79 ---GD--------------WVDAIVILAVVLLNAIIGFVQEYRAEKALEALKKLLAPTAR--VLRDGKWVEIPAEELVPG 139
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  210 DIAQIKYGDLLPADGVLIQGNDLKIDESSLTGESDHVRKAA----------DKDPMLLSGTHVMEGSGRMVVTAVGvnsq 279
Cdd:COG0474   140 DIVLLEAGDRVPADLRLLEAKDLQVDESALTGESVPVEKSAdplpedaplgDRGNMVFMGTLVTSGRGTAVVVATG---- 215
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  280 sgiiftllgaggeeeekkekkgqaledghplpdcshpsshpiatiatdgaasantpANTSLvnGKMqdgnmennqtkvkk 359
Cdd:COG0474   216 --------------------------------------------------------MNTEF--GKI-------------- 223
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  360 qdgaAAMemqpLKSAeggeteekekkktsvsKKEKSVLQGKLTKLAVQIGKAGLVMSAITVIILVLyfaidtfvrQKRPW 439
Cdd:COG0474   224 ----AKL----LQEA----------------EEEKTPLQKQLDRLGKLLAIIALVLAALVFLIGLL---------RGGPL 270
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  440 LTectpiyiqyfvkFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNR 519
Cdd:COG0474   271 LE------------ALLFAVALAVAAIPEGLPAVVTITLALGAQRMAKRNAIVRRLPAVETLGSVTVICTDKTGTLTQNK 338
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  520 MTAVQVYVADVHYktipEPTSLPSKTLDILVNAISLNSayttkilpaDKEGGLPKQVGNKTECGFLGLVLDVKRDYQTIR 599
Cdd:COG0474   339 MTVERVYTGGGTY----EVTGEFDPALEELLRAAALCS---------DAQLEEETGLGDPTEGALLVAAAKAGLDVEELR 405
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  600 NQIPeekLYKVYTFNSVRKSMSTVIKLPDGSFRMYSKGASEIILKKCSRILSEvGEPRVFRPRDRDEMVKKVIEpMACDG 679
Cdd:COG0474   406 KEYP---RVDEIPFDSERKRMSTVHEDPDGKRLLIVKGAPEVVLALCTRVLTG-GGVVPLTEEDRAEILEAVEE-LAAQG 480
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  680 LRTICVGYRDFPKDPEpnwEDENNILTDLTAICVVGIEDPVRPEVPDAIQKCQRAGITVRMVTGDNINTARAIAIKCGII 759
Cdd:COG0474   481 LRVLAVAYKELPADPE---LDSEDDESDLTFLGLVGMIDPPRPEAKEAIAECRRAGIRVKMITGDHPATARAIARQLGLG 557
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  760 HPGEDflCIDGKEfnrrIRNEKGEVEQERIDKVwpklRVLARSSPTDKHTLVKgiidsTLVDQRQVVAVTGDGTNDGPAL 839
Cdd:COG0474   558 DDGDR--VLTGAE----LDAMSDEELAEAVEDV----DVFARVSPEHKLRIVK-----ALQANGHVVAMTGDGVNDAPAL 622
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  840 KKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAV 919
Cdd:COG0474   623 KAADIGIAMGITGTDVAKEAADIVLLDDNFATIVAAVEEGRRIYDNIRKFIKYLLSSNFGEVLSVLLASLLGLPLPLTPI 702
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  920 QMLWVNLIMDTFASLALATEPPTESLLMRKPYGRNKPLISSTMTKNILGHGVYQLVIIFSLLFVGeqifdIDSGRNAPLH 999
Cdd:COG0474   703 QILWINLVTDGLPALALGFEPVEPDVMKRPPRWPDEPILSRFLLLRILLLGLLIAIFTLLTFALA-----LARGASLALA 777
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464 1000 SppsehyTIIFNTFVMMQLFNEINARKIHgeRNVFD-GIFRNPIFCSIVVGTFAIQIVIVQ--FGGKPFSCSPLDLEKWM 1076
Cdd:COG0474   778 R------TMAFTTLVLSQLFNVFNCRSER--RSFFKsGLFPNRPLLLAVLLSLLLQLLLIYvpPLQALFGTVPLPLSDWL 849
                        1050
                  ....*....|....*.
gi 181339464 1077 WCVFLGMGELVWGQVI 1092
Cdd:COG0474   850 LILGLALLYLLLVELV 865
Cation_ATPase_C pfam00689
Cation transporting ATPase, C-terminus; Members of this families are involved in Na+/K+, H+/K+, ...
914-1092 2.53e-48

Cation transporting ATPase, C-terminus; Members of this families are involved in Na+/K+, H+/K+, Ca++ and Mg++ transport. This family represents 5 transmembrane helices.


Pssm-ID: 376368 [Multi-domain]  Cd Length: 175  Bit Score: 169.73  E-value: 2.53e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   914 SPLKAVQMLWVNLIMDTFASLALATEPPTESLLMRKPYGRNKPLISSTMTKNILGHGVYQLVIIFSLLFVGEQIFDIDSG 993
Cdd:pfam00689    2 LPLTPIQILWINLVTDGLPALALGFEPPEPDLMKRPPRKPKEPLFSRKMLRRILLQGLLIAILTLLVFFLGLLGFGISES 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   994 RNAplhsppsehYTIIFNTFVMMQLFNEINARKIHGERNVFdGIFRNPIFCSIVVGTFAIQIVIVQ--FGGKPFSCSPLD 1071
Cdd:pfam00689   82 QNA---------QTMAFNTLVLSQLFNALNARSLRRSLFKI-GLFSNKLLLLAILLSLLLQLLIIYvpPLQAVFGTTPLS 151
                          170       180
                   ....*....|....*....|.
gi 181339464  1072 LEKWMWCVFLGMGELVWGQVI 1092
Cdd:pfam00689  152 LEQWLIVLLLALVVLLVVELR 172
PRK10517 PRK10517
magnesium-transporting P-type ATPase MgtA;
199-904 2.45e-39

magnesium-transporting P-type ATPase MgtA;


Pssm-ID: 236705 [Multi-domain]  Cd Length: 902  Bit Score: 158.69  E-value: 2.45e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  199 IQLPVADILVGDIAQIKYGDLLPADGVLIQGNDLKIDESSLTGESDHVRKAA-----------DKDPMLLSGTHVMEGSG 267
Cdd:PRK10517  176 LEIPIDQLVPGDIIKLAAGDMIPADLRILQARDLFVAQASLTGESLPVEKFAttrqpehsnplECDTLCFMGTNVVSGTA 255
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  268 RMVVTAVGVNSQSGIIftllgaggeeeekkekkgqaledghplpdcshpsSHPIatIATDGAASAntpantslvngkMQD 347
Cdd:PRK10517  256 QAVVIATGANTWFGQL----------------------------------AGRV--SEQDSEPNA------------FQQ 287
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  348 GnmennqtkvkkqdgaaamemqplksaeggeteekekkktsVSKKekSVLqgkLTKLAvqigkagLVMSAItviilVLYf 427
Cdd:PRK10517  288 G----------------------------------------ISRV--SWL---LIRFM-------LVMAPV-----VLL- 309
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  428 aIDTFVrqKRPWlTECtpiyiqyfvkfFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAI 507
Cdd:PRK10517  310 -INGYT--KGDW-WEA-----------ALFALSVAVGLTPEMLPMIVTSTLARGAVKLSKQKVIVKRLDAIQNFGAMDIL 374
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  508 CSDKTGTLTTNRMtavqvyVADVHYKTIPEPTSlpsktlDILVNAIsLNSAYTT--KILpadkeggLPKQVgnkTECGFL 585
Cdd:PRK10517  375 CTDKTGTLTQDKI------VLENHTDISGKTSE------RVLHSAW-LNSHYQTglKNL-------LDTAV---LEGVDE 431
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  586 GLVLDVKRDYQTIrNQIPeeklykvytFNSVRKSMSTVIKLPDGSFRMYSKGASEIILKKCSRIlsEVGEPRVFRPRDRD 665
Cdd:PRK10517  432 ESARSLASRWQKI-DEIP---------FDFERRRMSVVVAENTEHHQLICKGALEEILNVCSQV--RHNGEIVPLDDIML 499
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  666 EMVKKVIEPMACDGLRTICVGYRDFPKDPEpNWE--DENniltDLTAICVVGIEDPVRPEVPDAIQKCQRAGITVRMVTG 743
Cdd:PRK10517  500 RRIKRVTDTLNRQGLRVVAVATKYLPAREG-DYQraDES----DLILEGYIAFLDPPKETTAPALKALKASGVTVKILTG 574
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  744 DNINTARAIAIKCGIIHP----GEDFLCIDGKEFNRRIRNEkgeveqeridkvwpklRVLARSSPTDKHTLVKgiidsTL 819
Cdd:PRK10517  575 DSELVAAKVCHEVGLDAGevliGSDIETLSDDELANLAERT----------------TLFARLTPMHKERIVT-----LL 633
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  820 VDQRQVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLqfQLTV--- 896
Cdd:PRK10517  634 KREGHVVGFMGDGINDAPALRAADIGISVD-GAVDIAREAADIILLEKSLMVLEEGVIEGRRTFANMLKYI--KMTAssn 710
                         730
                  ....*....|
gi 181339464  897 --NVVAVIVA 904
Cdd:PRK10517  711 fgNVFSVLVA 720
ATP_Ca_trans_C pfam12424
Plasma membrane calcium transporter ATPase C terminal; This domain family is found in ...
1137-1183 5.73e-27

Plasma membrane calcium transporter ATPase C terminal; This domain family is found in eukaryotes, and is approximately 60 amino acids in length. The family is found in association with pfam00689, pfam00122, pfam00702, pfam00690. There is a conserved QTQ sequence motif. This family is the C terminal of a calcium transporting ATPase located in the plasma membrane.


Pssm-ID: 463575  Cd Length: 47  Bit Score: 104.02  E-value: 5.73e-27
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 181339464  1137 GQILWFRGLNRIQTQIRVVNAFRSSLYEGLEKPESRTSIHNFMTHPE 1183
Cdd:pfam12424    1 GQILWFRGLNRIQTQIRVVKAFQSSLREGIQKPYLRNSIHSFMSHPE 47
Cation_ATPase_N smart00831
Cation transporter/ATPase, N-terminus; This entry represents the conserved N-terminal region ...
51-118 3.91e-11

Cation transporter/ATPase, N-terminus; This entry represents the conserved N-terminal region found in several classes of cation-transporting P-type ATPases, including those that transport H+, Na+, Ca2+, Na+/K+, and H+/K+. In the H+/K+- and Na+/K+-exchange P-ATPases, this domain is found in the catalytic alpha chain. In gastric H+/K+-ATPases, this domain undergoes reversible sequential phosphorylation inducing conformational changes that may be important for regulating the function of these ATPases.


Pssm-ID: 214842 [Multi-domain]  Cd Length: 75  Bit Score: 59.90  E-value: 3.91e-11
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 181339464     51 EGLCQRLKTSPTEGLAglATDLDKRKEVFGRNLIPPKKPKTFLQLVWEALQDVTLIILEIAALISLGL 118
Cdd:smart00831   10 EEVLERLQTDLEKGLS--SEEAARRLERYGPNELPPPKKTSPLLRFLRQFHNPLIYILLAAAVLSALL 75
 
Name Accession Description Interval E-value
ATPase-IIB_Ca TIGR01517
plasma-membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase ...
9-1096 0e+00

plasma-membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase responsible for translocating calcium ions across the plasma membrane of eukaryotes, out of the cell. In some organisms, this type of pump may also be found in vacuolar membranes. In humans and mice, at least, there are multiple isoforms of the PMCA pump with overlapping but not redundant functions. Accordingly, there are no human diseases linked to PMCA defects, although alterations of PMCA function do elicit physiological effects. The calcium P-type ATPases have been characterized as Type IIB based on a phylogenetic analysis which distinguishes this group from the Type IIA SERCA calcium pump. A separate analysis divides Type IIA into sub-types (SERCA and PMR1) which are represented by two corresponding models (TIGR01116 and TIGR01522). This model is well separated from those.


Pssm-ID: 273668 [Multi-domain]  Cd Length: 956  Bit Score: 1297.44  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464     9 KNQRNDSNHEGGFGCSLMELRSLMELRGTEAV---VKIQEDYGGTEGLCQRLKTSPTEGLAGLATDLDKRKEVFGRNLIP 85
Cdd:TIGR01517    1 MESVRRRTSIRDNFTDGFDVGVSILTDLTDIFkkaMPLYEKLGGAEGIATKLKTDLNEGVRLSSSTLERREKVYGKNELP 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464    86 PKKPKTFLQLVWEALQDVTLIILEIAALISLGLSFYQP-PGEGNtdacgdakagaedeGESEAGWIEGAAILLSVVCVVL 164
Cdd:TIGR01517   81 EKPPKSFLQIVWAALSDQTLILLSVAAVVSLVLGLYVPsVGEDK--------------ADTETGWIEGVAILVSVILVVL 146
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   165 VTAFNDWSKEKQFRGLQsRIEQEQKFQVVRGGQVIQLPVADILVGDIAQIKYGDLLPADGVLIQGNDLKIDESSLTGESD 244
Cdd:TIGR01517  147 VTAVNDYKKELQFRQLN-REKSAQKIAVIRGGQEQQISIHDIVVGDIVSLSTGDVVPADGVFISGLSLEIDESSITGESD 225
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   245 HVRKAADKDPMLLSGTHVMEGSGRMVVTAVGVNSQSGIIFTLLgaggeeeekkekkgqaledghplpdcshpsshpiati 324
Cdd:TIGR01517  226 PIKKGPVQDPFLLSGTVVNEGSGRMLVTAVGVNSFGGKLMMEL------------------------------------- 268
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   325 atdgaasantpantslvngkmqdgnmennqtkvkkqdgaaamemqplksaeggeteekekkktSVSKKEKSVLQGKLTKL 404
Cdd:TIGR01517  269 ---------------------------------------------------------------RQAGEEETPLQEKLSEL 285
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   405 AVQIGKAGLVMSAITVIILVLYFAIDTFVRQKRPwltECTPIYIQYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKK 484
Cdd:TIGR01517  286 AGLIGKFGMGSAVLLFLVLSLRYVFRIIRGDGRF---EDTEEDAQTFLDHFIIAVTIVVVAVPEGLPLAVTIALAYSMKK 362
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   485 MMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTAVQVYVADVHYKTIPE--PTSLPSKTLDILVNAISLNSayttk 562
Cdd:TIGR01517  363 MMKDNNLVRHLAACETMGSATAICSDKTGTLTQNVMSVVQGYIGEQRFNVRDEivLRNLPAAVRNILVEGISLNS----- 437
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   563 ILPADKE-GGLPKQVGNKTECGFLGLVLDVKRDYQTIRNQIPEEKLYKVYTFNSVRKSMSTVIKLPDGSFRMYSKGASEI 641
Cdd:TIGR01517  438 SSEEVVDrGGKRAFIGSKTECALLDFGLLLLLQSRDVQEVRAEEKVVKIYPFNSERKFMSVVVKHSGGKYREFRKGASEI 517
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   642 ILKKCSRILSEVGEPRVFRPRDRDEmVKKVIEPMACDGLRTICVGYRDFPKDPEPNWEDENNiltDLTAICVVGIEDPVR 721
Cdd:TIGR01517  518 VLKPCRKRLDSNGEATPISEDDKDR-CADVIEPLASDALRTICLAYRDFAPEEFPRKDYPNK---GLTLIGVVGIKDPLR 593
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   722 PEVPDAIQKCQRAGITVRMVTGDNINTARAIAIKCGIIHPGEdfLCIDGKEFNRRIRNEkgeveqerIDKVWPKLRVLAR 801
Cdd:TIGR01517  594 PGVREAVQECQRAGITVRMVTGDNIDTAKAIARNCGILTFGG--LAMEGKEFRSLVYEE--------MDPILPKLRVLAR 663
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   802 SSPTDKHTLVKgiidsTLVDQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRN 881
Cdd:TIGR01517  664 SSPLDKQLLVL-----MLKDMGEVVAVTGDGTNDAPALKLADVGFSMGISGTEVAKEASDIILLDDNFASIVRAVKWGRN 738
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   882 VYDSISKFLQFQLTVNVVAVIVAFTGACIT--QDSPLKAVQMLWVNLIMDTFASLALATEPPTESLLMRKPYGRNKPLIS 959
Cdd:TIGR01517  739 VYDNIRKFLQFQLTVNVVAVILTFVGSCISssHTSPLTAVQLLWVNLIMDTLAALALATEPPTEALLDRKPIGRNAPLIS 818
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   960 STMTKNILGHGVYQLVIIFSLLFVGEQIFDIDSGRNAPlHSPPSEHYTIIFNTFVMMQLFNEINARKIHGERNVFDGIFR 1039
Cdd:TIGR01517  819 RSMWKNILGQAGYQLVVTFILLFAGGSIFDVSGPDEIT-SHQQGELNTIVFNTFVLLQLFNEINARKLYEGMNVFEGLFK 897
                         1050      1060      1070      1080      1090
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 181339464  1040 NPIFCSIVVGTFAIQIVIVQFGGKPFSCSPLDLEKWMWCVFLGMGELVWGQVISTIP 1096
Cdd:TIGR01517  898 NRIFVTIMGFTFGFQVIIVEFGGSFFSTVSLSIEQWIGCVLLGMLSLIFGVLLRLIP 954
P-type_ATPase_Ca_PMCA-like cd02081
animal plasma membrane Ca2(+)-ATPases (PMCA), similar to human ATP2B1-4/PMCA1-4, and related ...
72-962 0e+00

animal plasma membrane Ca2(+)-ATPases (PMCA), similar to human ATP2B1-4/PMCA1-4, and related Ca2(+)-ATPases including Saccharomyces cerevisiae vacuolar PMC1; Animal PMCAs function to export Ca(2+) from cells and play a role in regulating Ca(2+) signals following stimulus induction and in preventing calcium toxicity. Many PMCA pump variants exist due to alternative splicing of transcripts. PMCAs are regulated by the binding of calmodulin or by kinase-mediated phosphorylation. Saccharomyces cerevisiae vacuolar transporter Pmc1p facilitates the accumulation of Ca2+ into vacuoles. Pmc1p is not regulated by direct calmodulin binding but responds to the calmodulin/calcineurin-signaling pathway and is controlled by the transcription factor complex Tcn1p/Crz1p. Similarly, the expression of the gene for Dictyostelium discoideum Ca(2+)-ATPase PAT1, patA, is under the control of a calcineurin-dependent transcription factor. Plant vacuolar Ca(2+)-ATPases, are regulated by direct-calmodulin binding. Plant Ca(2+)-ATPases are present at various cellular locations including the plasma membrane, endoplasmic reticulum, chloroplast and vacuole. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319776 [Multi-domain]  Cd Length: 721  Bit Score: 1277.14  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   72 LDKRKEVFGRNLIPPKKPKTFLQLVWEALQDVTLIILEIAALISLGLSFYQPPGEGntdacgdakagaedegESEAGWIE 151
Cdd:cd02081     1 LEHRREVYGKNEIPPKPPKSFLQLVWEALQDPTLIILLIAAIVSLGLGFYTPFGEG----------------EGKTGWIE 64
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  152 GAAILLSVVCVVLVTAFNDWSKEKQFRGLQSRIEqEQKFQVVRGGQVIQLPVADILVGDIAQIKYGDLLPADGVLIQGND 231
Cdd:cd02081    65 GVAILVAVILVVLVTAGNDYQKEKQFRKLNSKKE-DQKVTVIRDGEVIQISVFDIVVGDIVQLKYGDLIPADGLLIEGND 143
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  232 LKIDESSLTGESDHVRKAAD---KDPMLLSGTHVMEGSGRMVVTAVGVNSQSGIIFTLLgaggeeeekkekkgqaledgh 308
Cdd:cd02081   144 LKIDESSLTGESDPIKKTPDnqiPDPFLLSGTKVLEGSGKMLVTAVGVNSQTGKIMTLL--------------------- 202
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  309 plpdcshpsshpiatiatdgaasantpantslvngkmqdgnmennqtkvkkqdgaaamemqplksaeggeteekekkktS 388
Cdd:cd02081   203 -------------------------------------------------------------------------------R 203
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  389 VSKKEKSVLQGKLTKLAVQIGKAGLVMSAITVIILVLYFAIDTFVRQKRPWltecTPIYIQYFVKFFIIGVTVLVVAVPE 468
Cdd:cd02081   204 AENEEKTPLQEKLTKLAVQIGKVGLIVAALTFIVLIIRFIIDGFVNDGKSF----SAEDLQEFVNFFIIAVTIIVVAVPE 279
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  469 GLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTAVQVYVadvhyktipeptslpsktldi 548
Cdd:cd02081   280 GLPLAVTLSLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTQNRMTVVQGYI--------------------- 338
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  549 lvnaislnsayttkilpadkegglpkqvGNKTECGFLGLVLDVKRDYQtIRNQIPEEKLYKVYTFNSVRKSMSTVIKLPD 628
Cdd:cd02081   339 ----------------------------GNKTECALLGFVLELGGDYR-YREKRPEEKVLKVYPFNSARKRMSTVVRLKD 389
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  629 GSFRMYSKGASEIILKKCSRILSEVGEpRVFRPRDRDEMVKKVIEPMACDGLRTICVGYRDFPKDPEP----NWEDENNI 704
Cdd:cd02081   390 GGYRLYVKGASEIVLKKCSYILNSDGE-VVFLTSEKKEEIKRVIEPMASDSLRTIGLAYRDFSPDEEPtaerDWDDEEDI 468
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  705 LTDLTAICVVGIEDPVRPEVPDAIQKCQRAGITVRMVTGDNINTARAIAIKCGIIHPGEDFLCIDGKEFNRRIRNEKGEV 784
Cdd:cd02081   469 ESDLTFIGIVGIKDPLRPEVPEAVAKCQRAGITVRMVTGDNINTARAIARECGILTEGEDGLVLEGKEFRELIDEEVGEV 548
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  785 EQERIDKVWPKLRVLARSSPTDKHTLVKGIIDStlvdqRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIIL 864
Cdd:cd02081   549 CQEKFDKIWPKLRVLARSSPEDKYTLVKGLKDS-----GEVVAVTGDGTNDAPALKKADVGFAMGIAGTEVAKEASDIIL 623
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  865 TDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTFASLALATEPPTES 944
Cdd:cd02081   624 LDDNFSSIVKAVMWGRNVYDSIRKFLQFQLTVNVVAVILAFIGAVVTKDSPLTAVQMLWVNLIMDTLAALALATEPPTED 703
                         890
                  ....*....|....*...
gi 181339464  945 LLMRKPYGRNKPLISSTM 962
Cdd:cd02081   704 LLKRKPYGRDKPLISRTM 721
MgtA COG0474
Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];
50-1092 0e+00

Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];


Pssm-ID: 440242 [Multi-domain]  Cd Length: 874  Bit Score: 660.26  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   50 TEGLCQRLKTSPtEGLAglATDLDKRKEVFGRNLIPPKKPKTFLQLVWEALQDVTLIILEIAALISLGLsfyqppgegnt 129
Cdd:COG0474    13 AEEVLAELGTSE-EGLS--SEEAARRLARYGPNELPEEKKRSLLRRFLEQFKNPLILILLAAAVISALL----------- 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  130 dacGDakagaedegeseagWIEGAAILLSVVCVVLVTAFNDWSKEKQFRGLQSRIEQEQKfqVVRGGQVIQLPVADILVG 209
Cdd:COG0474    79 ---GD--------------WVDAIVILAVVLLNAIIGFVQEYRAEKALEALKKLLAPTAR--VLRDGKWVEIPAEELVPG 139
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  210 DIAQIKYGDLLPADGVLIQGNDLKIDESSLTGESDHVRKAA----------DKDPMLLSGTHVMEGSGRMVVTAVGvnsq 279
Cdd:COG0474   140 DIVLLEAGDRVPADLRLLEAKDLQVDESALTGESVPVEKSAdplpedaplgDRGNMVFMGTLVTSGRGTAVVVATG---- 215
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  280 sgiiftllgaggeeeekkekkgqaledghplpdcshpsshpiatiatdgaasantpANTSLvnGKMqdgnmennqtkvkk 359
Cdd:COG0474   216 --------------------------------------------------------MNTEF--GKI-------------- 223
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  360 qdgaAAMemqpLKSAeggeteekekkktsvsKKEKSVLQGKLTKLAVQIGKAGLVMSAITVIILVLyfaidtfvrQKRPW 439
Cdd:COG0474   224 ----AKL----LQEA----------------EEEKTPLQKQLDRLGKLLAIIALVLAALVFLIGLL---------RGGPL 270
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  440 LTectpiyiqyfvkFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNR 519
Cdd:COG0474   271 LE------------ALLFAVALAVAAIPEGLPAVVTITLALGAQRMAKRNAIVRRLPAVETLGSVTVICTDKTGTLTQNK 338
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  520 MTAVQVYVADVHYktipEPTSLPSKTLDILVNAISLNSayttkilpaDKEGGLPKQVGNKTECGFLGLVLDVKRDYQTIR 599
Cdd:COG0474   339 MTVERVYTGGGTY----EVTGEFDPALEELLRAAALCS---------DAQLEEETGLGDPTEGALLVAAAKAGLDVEELR 405
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  600 NQIPeekLYKVYTFNSVRKSMSTVIKLPDGSFRMYSKGASEIILKKCSRILSEvGEPRVFRPRDRDEMVKKVIEpMACDG 679
Cdd:COG0474   406 KEYP---RVDEIPFDSERKRMSTVHEDPDGKRLLIVKGAPEVVLALCTRVLTG-GGVVPLTEEDRAEILEAVEE-LAAQG 480
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  680 LRTICVGYRDFPKDPEpnwEDENNILTDLTAICVVGIEDPVRPEVPDAIQKCQRAGITVRMVTGDNINTARAIAIKCGII 759
Cdd:COG0474   481 LRVLAVAYKELPADPE---LDSEDDESDLTFLGLVGMIDPPRPEAKEAIAECRRAGIRVKMITGDHPATARAIARQLGLG 557
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  760 HPGEDflCIDGKEfnrrIRNEKGEVEQERIDKVwpklRVLARSSPTDKHTLVKgiidsTLVDQRQVVAVTGDGTNDGPAL 839
Cdd:COG0474   558 DDGDR--VLTGAE----LDAMSDEELAEAVEDV----DVFARVSPEHKLRIVK-----ALQANGHVVAMTGDGVNDAPAL 622
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  840 KKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAV 919
Cdd:COG0474   623 KAADIGIAMGITGTDVAKEAADIVLLDDNFATIVAAVEEGRRIYDNIRKFIKYLLSSNFGEVLSVLLASLLGLPLPLTPI 702
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  920 QMLWVNLIMDTFASLALATEPPTESLLMRKPYGRNKPLISSTMTKNILGHGVYQLVIIFSLLFVGeqifdIDSGRNAPLH 999
Cdd:COG0474   703 QILWINLVTDGLPALALGFEPVEPDVMKRPPRWPDEPILSRFLLLRILLLGLLIAIFTLLTFALA-----LARGASLALA 777
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464 1000 SppsehyTIIFNTFVMMQLFNEINARKIHgeRNVFD-GIFRNPIFCSIVVGTFAIQIVIVQ--FGGKPFSCSPLDLEKWM 1076
Cdd:COG0474   778 R------TMAFTTLVLSQLFNVFNCRSER--RSFFKsGLFPNRPLLLAVLLSLLLQLLLIYvpPLQALFGTVPLPLSDWL 849
                        1050
                  ....*....|....*.
gi 181339464 1077 WCVFLGMGELVWGQVI 1092
Cdd:COG0474   850 LILGLALLYLLLVELV 865
P-type_ATPase_Ca_prok cd02089
prokaryotic P-type Ca(2+)-ATPase similar to Synechococcus elongatus sp. strain PCC 7942 PacL ...
74-950 3.32e-158

prokaryotic P-type Ca(2+)-ATPase similar to Synechococcus elongatus sp. strain PCC 7942 PacL and Listeria monocytogenes LMCA1; Ca(2+) transport ATPase is a plasma membrane protein which pumps Ca(2+) ion out of the cytoplasm. This prokaryotic subfamily includes the Ca(2+)-ATPase Synechococcus elongatus PacL, Listeria monocytogenes Ca(2+)-ATPase 1 (LMCA1) which has a low Ca(2+) affinity and a high pH optimum (pH about 9) and may remove Ca(2+) from the microorganism in environmental conditions when e.g. stressed by high Ca(2+) and alkaline pH, and the Bacillus subtilis putative P-type Ca(2+)-transport ATPase encoded by the yloB gene, which is expressed during sporulation. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319781 [Multi-domain]  Cd Length: 674  Bit Score: 489.05  E-value: 3.32e-158
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   74 KRKEVFGRNLIPPKKPKTFLQLVWEALQDVTLIILEIAALISLGLsfyqppgegntdacgdakagaedegeseAGWIEGA 153
Cdd:cd02089     9 RRLAKYGPNELVEKKKRSPWKKFLEQFKDFMVIVLLAAAVISGVL----------------------------GEYVDAI 60
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  154 AILLSVVCVVLVTAFNDWSKEKQFRGLQSRIEQEQKfqVVRGGQVIQLPVADILVGDIAQIKYGDLLPADGVLIQGNDLK 233
Cdd:cd02089    61 VIIAIVILNAVLGFVQEYKAEKALAALKKMSAPTAK--VLRDGKKQEIPARELVPGDIVLLEAGDYVPADGRLIESASLR 138
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  234 IDESSLTGESDHVRKAADKDP-----------MLLSGTHVMEGSGRMVVTAVGVNSQSGIIFTLLgaggeeeekkekkgq 302
Cdd:cd02089   139 VEESSLTGESEPVEKDADTLLeedvplgdrknMVFSGTLVTYGRGRAVVTATGMNTEMGKIATLL--------------- 203
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  303 aledghplpdcshpsshpiatiatdgaasantpantslvngkmqdgnmenNQTKvkkqdgaaamemqplksaeggeteek 382
Cdd:cd02089   204 --------------------------------------------------EETE-------------------------- 207
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  383 ekkktsvskKEKSVLQGKLTKLAVQIGKAGLVMSAITVIILVLyfaidtfvrQKRPWLTEctpiyiqyfvkfFIIGVTVL 462
Cdd:cd02089   208 ---------EEKTPLQKRLDQLGKRLAIAALIICALVFALGLL---------RGEDLLDM------------LLTAVSLA 257
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  463 VVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTAVQVYvadvhykTIPEPTSlp 542
Cdd:cd02089   258 VAAIPEGLPAIVTIVLALGVQRMAKRNAIIRKLPAVETLGSVSVICSDKTGTLTQNKMTVEKIY-------TIGDPTE-- 328
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  543 sktldilvnaislnsaytTKILPADKEGGLPKqvgnktecgflglvLDVKRDYQTIrNQIPeeklykvytFNSVRKSMST 622
Cdd:cd02089   329 ------------------TALIRAARKAGLDK--------------EELEKKYPRI-AEIP---------FDSERKLMTT 366
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  623 VIKLPDGsFRMYSKGASEIILKKCSRILSEvGEPRVFRPRDRDEmVKKVIEPMACDGLRTICVGYRDFPKDPEPNWEDen 702
Cdd:cd02089   367 VHKDAGK-YIVFTKGAPDVLLPRCTYIYIN-GQVRPLTEEDRAK-ILAVNEEFSEEALRVLAVAYKPLDEDPTESSED-- 441
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  703 nILTDLTAICVVGIEDPVRPEVPDAIQKCQRAGITVRMVTGDNINTARAIAIKCGIIHPGEdfLCIDGKEFNrrirnekg 782
Cdd:cd02089   442 -LENDLIFLGLVGMIDPPRPEVKDAVAECKKAGIKTVMITGDHKLTARAIAKELGILEDGD--KALTGEELD-------- 510
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  783 EVEQERIDKVWPKLRVLARSSPTDKHTLVKgiidsTLVDQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDI 862
Cdd:cd02089   511 KMSDEELEKKVEQISVYARVSPEHKLRIVK-----ALQRKGKIVAMTGDGVNDAPALKAADIGVAMGITGTDVAKEAADM 585
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  863 ILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTFASLALATEPPT 942
Cdd:cd02089   586 ILTDDNFATIVAAVEEGRTIYDNIRKFIRYLLSGNVGEILTMLLAPLLGWPVPLLPIQLLWINLLTDGLPALALGVEPAE 665

                  ....*...
gi 181339464  943 ESLLMRKP 950
Cdd:cd02089   666 PDIMDRKP 673
ATPase_P-type TIGR01494
ATPase, P-type (transporting), HAD superfamily, subfamily IC; The P-type ATPases are a large ...
167-936 1.26e-136

ATPase, P-type (transporting), HAD superfamily, subfamily IC; The P-type ATPases are a large family of trans-membrane transporters acting on charged substances. The distinguishing feature of the family is the formation of a phosphorylated intermediate (aspartyl-phosphate) during the course of the reaction. Another common name for these enzymes is the E1-E2 ATPases based on the two isolable conformations: E1 (unphosphorylated) and E2 (phosphorylated). Generally, P-type ATPases consist of only a single subunit encompassing the ATPase and ion translocation pathway, however, in the case of the potassium (TIGR01497) and sodium/potassium (TIGR01106) varieties, these functions are split between two subunits. Additional small regulatory or stabilizing subunits may also exist in some forms. P-type ATPases are nearly ubiquitous in life and are found in numerous copies in higher organisms (at least 45 in Arabidopsis thaliana, for instance). Phylogenetic analyses have revealed that the P-type ATPase subfamily is divided up into groups based on substrate specificities and this is represented in the various subfamily and equivalog models that have been made: IA (K+) TIGR01497, IB (heavy metals) TIGR01525, IIA1 (SERCA-type Ca++) TIGR01116, IIA2 (PMR1-type Ca++) TIGR01522, IIB (PMCA-type Ca++) TIGR01517, IIC (Na+/K+, H+/K+ antiporters) TIGR01106, IID (fungal-type Na+ and K+) TIGR01523, IIIA (H+) TIGR01647, IIIB (Mg++) TIGR01524, IV (phospholipid, flippase) TIGR01652 and V (unknown specificity) TIGR01657. The crystal structure of one calcium-pumping ATPase and an analysis of the fold of the catalytic domain of the P-type ATPases have been published. These reveal that the catalytic core of these enzymes is a haloacid dehalogenase(HAD)-type aspartate-nucleophile hydrolase. The location of the ATP-binding loop in between the first and second HAD conserved catalytic motifs defines these enzymes as members of subfamily I of the HAD superfamily (see also TIGR01493, TIGR01509, TIGR01549, TIGR01544 and TIGR01545). Based on these classifications, the P-type ATPase _superfamily_ corresponds to the IC subfamily of the HAD superfamily.


Pssm-ID: 273656 [Multi-domain]  Cd Length: 545  Bit Score: 427.50  E-value: 1.26e-136
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   167 AFNDWSKEKQFRGLQSRIEQEQKFQVVRGGQViQLPVADILVGDIAQIKYGDLLPADGVLIQGnDLKIDESSLTGESDHV 246
Cdd:TIGR01494   14 VKQKLKAEDALRSLKDSLVNTATVLVLRNGWK-EISSKDLVPGDVVLVKSGDTVPADGVLLSG-SAFVDESSLTGESLPV 91
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   247 RKAADKDP-MLLSGTHVMEGSGRMVVTAVGVNSQSGIIftllgaggeeeekkekkgqaledghplpdcshpsshpIATIA 325
Cdd:TIGR01494   92 LKTALPDGdAVFAGTINFGGTLIVKVTATGILTTVGKI-------------------------------------AVVVY 134
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   326 TdgaasantpantslvngkmqdgnmennqtkvkkqdgaaAMEmqplksaeggeteekekkktsvskkEKSVLQGKLTKLA 405
Cdd:TIGR01494  135 T--------------------------------------GFS-------------------------TKTPLQSKADKFE 151
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   406 VQIGKAGLVMSAITVIILVLYFAIDtfvrqkrpwltectpiyIQYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKM 485
Cdd:TIGR01494  152 NFIFILFLLLLALAVFLLLPIGGWD-----------------GNSIYKAILRALAVLVIAIPCALPLAVSVALAVGDARM 214
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   486 MKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTAVQVYVADVHYKTIPEptslpsktldilvnaislnsayttkilP 565
Cdd:TIGR01494  215 AKKGILVKNLNALEELGKVDVICFDKTGTLTTNKMTLQKVIIIGGVEEASLA---------------------------L 267
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   566 ADKEGGLPKQVGNKTECgflGLVLDVKRDYQTiRNQIPEEKLYKVYTFNSVRKSMSTVIKLPDGSFRMYSKGASEIILKK 645
Cdd:TIGR01494  268 ALLAASLEYLSGHPLER---AIVKSAEGVIKS-DEINVEYKILDVFPFSSVLKRMGVIVEGANGSDLLFVKGAPEFVLER 343
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   646 CSRIlsevgeprvfrprdrdEMVKKVIEPMACDGLRTICVGYRDFPkdpepnwedennilTDLTAICVVGIEDPVRPEVP 725
Cdd:TIGR01494  344 CNNE----------------NDYDEKVDEYARQGLRVLAFASKKLP--------------DDLEFLGLLTFEDPLRPDAK 393
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   726 DAIQKCQRAGITVRMVTGDNINTARAIAIKCGIIhpgedflcidgkefnrrirnekgeveqeridkvwpklrVLARSSPT 805
Cdd:TIGR01494  394 ETIEALRKAGIKVVMLTGDNVLTAKAIAKELGID--------------------------------------VFARVKPE 435
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   806 DKHTLVKGIIDSTlvdqrQVVAVTGDGTNDGPALKKADVGFAMGIAgtDVAKEASDIILTDDNFSSIVKAVMWGRNVYDS 885
Cdd:TIGR01494  436 EKAAIVEALQEKG-----RTVAMTGDGVNDAPALKKADVGIAMGSG--DVAKAAADIVLLDDDLSTIVEAVKEGRKTFSN 508
                          730       740       750       760       770
                   ....*....|....*....|....*....|....*....|....*....|.
gi 181339464   886 ISKFLQFQLTVNVVAVIVAFTGACItqdsplkavqmlwvNLIMDTFASLAL 936
Cdd:TIGR01494  509 IKKNIFWAIAYNLILIPLALLLIVI--------------ILLPPLLAALAL 545
P-type_ATPase_cation cd02080
P-type cation-transporting ATPase similar to Exiguobacterium aurantiacum Mna, an Na(+)-ATPase, ...
74-1075 2.79e-134

P-type cation-transporting ATPase similar to Exiguobacterium aurantiacum Mna, an Na(+)-ATPase, and Synechocystis sp. PCC 6803 PMA1, a putative Ca(2+)-ATPase; This subfamily includes the P-type Na(+)-ATPase of an alkaliphilic bacterium Exiguobacterium aurantiacum Mna and cyanobacterium Synechocystis sp. PCC 6803 PMA1, a cation-transporting ATPase which may translocate calcium. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319775 [Multi-domain]  Cd Length: 819  Bit Score: 430.53  E-value: 2.79e-134
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   74 KRKEVFGRNLIPPKKPKTFLQLVWEALQDVTLIILEIAALISLGLsfyqppgegntdacgdakagaedeGEseagWIEGA 153
Cdd:cd02080     9 ERLERYGPNRLPEKKTKSPLLRFLRQFNNPLIYILLAAAVVTAFL------------------------GH----WVDAI 60
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  154 AILLSVVCVVLVTAFNDWSKEKQFRGLQSRIEQEQKfqVVRGGQVIQLPVADILVGDIAQIKYGDLLPADGVLIQGNDLK 233
Cdd:cd02080    61 VIFGVVLINAIIGYIQEGKAEKALAAIKNMLSPEAT--VLRDGKKLTIDAEELVPGDIVLLEAGDKVPADLRLIEARNLQ 138
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  234 IDESSLTGESDHVRKA----------ADKDPMLLSGTHVMEGSGRMVVTAVGVNSQSGIIFTLLGaggeeeekkekkgqa 303
Cdd:cd02080   139 IDESALTGESVPVEKQegpleedtplGDRKNMAYSGTLVTAGSATGVVVATGADTEIGRINQLLA--------------- 203
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  304 ledghplpdcshpsshpiatiatdGAASANTPantslvngkmqdgnmennqtkvkkqdgaaamemqplksaeggeteeke 383
Cdd:cd02080   204 ------------------------EVEQLATP------------------------------------------------ 211
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  384 kkktsvskkeksvLQGKLTKLAVQIGKAGLVMSAITVIIlvlyfaidTFVRQKRPWltectpiyiqyfVKFFIIGVTVLV 463
Cdd:cd02080   212 -------------LTRQIAKFSKALLIVILVLAALTFVF--------GLLRGDYSL------------VELFMAVVALAV 258
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  464 VAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTAVQVYVadvhyktipeptslps 543
Cdd:cd02080   259 AAIPEGLPAVITITLAIGVQRMAKRNAIIRRLPAVETLGSVTVICSDKTGTLTRNEMTVQAIVT---------------- 322
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  544 ktldiLVNAISLnsayttkilpaDKEGGLPKQVGNKTECGFLGLVLDVKRDYQTIRNQIPEEKlykVYTFNSVRKSMSTV 623
Cdd:cd02080   323 -----LCNDAQL-----------HQEDGHWKITGDPTEGALLVLAAKAGLDPDRLASSYPRVD---KIPFDSAYRYMATL 383
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  624 IKLpDGSFRMYSKGASEIILKKCSRILSEVGEprvfRPRDRDEMVKKViEPMACDGLRTICVGYRDFpkDPEPNWEDENN 703
Cdd:cd02080   384 HRD-DGQRVIYVKGAPERLLDMCDQELLDGGV----SPLDRAYWEAEA-EDLAKQGLRVLAFAYREV--DSEVEEIDHAD 455
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  704 ILTDLTAICVVGIEDPVRPEVPDAIQKCQRAGITVRMVTGDNINTARAIAIKCGIIHPGEdflCIDGKEFNRRIRNEKGE 783
Cdd:cd02080   456 LEGGLTFLGLQGMIDPPRPEAIAAVAECQSAGIRVKMITGDHAETARAIGAQLGLGDGKK---VLTGAELDALDDEELAE 532
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  784 VEQERidkvwpklRVLARSSPTDKHTLVKGiidstLVDQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDII 863
Cdd:cd02080   533 AVDEV--------DVFARTSPEHKLRLVRA-----LQARGEVVAMTGDGVNDAPALKQADIGIAMGIKGTEVAKEAADMV 599
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  864 LTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNV---VAVIVA-FTGACItqdsPLKAVQMLWVNLIMDTFASLALATE 939
Cdd:cd02080   600 LADDNFATIAAAVEEGRRVYDNLKKFILFTLPTNLgegLVIIVAiLFGVTL----PLTPVQILWINMVTAITLGLALAFE 675
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  940 PPTESLLMRKPYGRNKPLISSTMTKNILGHGVYQLVIIFSL-LFVGEQIFDIDSGRnaplhsppsehyTIIFNTFVMMQL 1018
Cdd:cd02080   676 PAEPGIMKRPPRDPSEPLLSRELIWRILLVSLLMLGGAFGLfLWALDRGYSLETAR------------TMAVNTIVVAQI 743
                         970       980       990      1000      1010      1020
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464 1019 FNEINARKIHgeRNVFD-GIFRNPIFCSIVVGTFAIQIVIVQ--FGGKPFSCSPLDLEKW 1075
Cdd:cd02080   744 FYLFNCRSLH--RSILKlGVFSNKILFLGIGALILLQLAFTYlpFMNSLFGTAPIDLVDW 801
P-type_ATPase_SERCA cd02083
sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA), similar to mammalian ATP2A1-3/SERCA1-3; ...
50-960 5.86e-123

sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA), similar to mammalian ATP2A1-3/SERCA1-3; SERCA is a transmembrane (Ca2+)-ATPase and a major regulator of Ca(2+) homeostasis and contractility in cardiac and skeletal muscle. It re-sequesters cytoplasmic Ca(2+) to the sarco/endoplasmic reticulum store, thereby also terminating Ca(2+)-induced signaling such as in muscle contraction. Three genes (ATP2A1-3/SERCA1-3) encode SERCA pumps in mammals, further isoforms exist due to alternative splicing of transcripts. The activity of SERCA is regulated by two small membrane proteins called phospholamban and sarcolipin. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319778 [Multi-domain]  Cd Length: 979  Bit Score: 404.75  E-value: 5.86e-123
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   50 TEGLCQRLKTSPTEGLAGlaTDLDKRKEVFGRNLIPPKKPKTFLQLVWEALQDVTLIILEIAALISLGLSFYqppgegnt 129
Cdd:cd02083     5 VEEVLAYFGVDPTRGLSD--EQVKRRREKYGPNELPAEEGKSLWELVLEQFDDLLVRILLLAAIISFVLALF-------- 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  130 dacgdakagaEDEGESEAGWIEGAAILLSVVCVvlvTAFNDWskekQFRGLQSRIEQEQKFQ-----VVRGGQVIQ-LPV 203
Cdd:cd02083    75 ----------EEGEEGVTAFVEPFVILLILIAN---AVVGVW----QERNAEKAIEALKEYEpemakVLRNGKGVQrIRA 137
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  204 ADILVGDIAQIKYGDLLPADG--VLIQGNDLKIDESSLTGESDHVRK--AADKDP---------MLLSGTHVMEGSGRMV 270
Cdd:cd02083   138 RELVPGDIVEVAVGDKVPADIriIEIKSTTLRVDQSILTGESVSVIKhtDVVPDPravnqdkknMLFSGTNVAAGKARGV 217
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  271 VTAVGVNsqsgiiftllgaggeeeekkekkgqaledghplpdcshpsshpiatiatdgaasantpanTSLvnGKMQDgnm 350
Cdd:cd02083   218 VVGTGLN------------------------------------------------------------TEI--GKIRD--- 232
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  351 ennqtkvkkqdgaaamEMQplksaeggeteekekkktsVSKKEKSVLQGKLTKLAVQIGKAglvmsaITVI-ILVLYFAI 429
Cdd:cd02083   233 ----------------EMA-------------------ETEEEKTPLQQKLDEFGEQLSKV------ISVIcVAVWAINI 271
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  430 DTFVRQKRP--WLTECtpIYiqyfvkFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAI 507
Cdd:cd02083   272 GHFNDPAHGgsWIKGA--IY------YFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVI 343
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  508 CSDKTGTLTTNRMTAVQVYVAD---------------VHYKTIPEPTSLPSKTL----DILVNAISLNSAYTTKILPADK 568
Cdd:cd02083   344 CSDKTGTLTTNQMSVSRMFILDkveddsslnefevtgSTYAPEGEVFKNGKKVKagqyDGLVELATICALCNDSSLDYNE 423
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  569 EGGLPKQVGNKTECGFLGLVLDV-----------KRDYQTIRNQIPEEKLYKVYT--FNSVRKSMSTVIKLPDGSF--RM 633
Cdd:cd02083   424 SKGVYEKVGEATETALTVLVEKMnvfntdksglsKRERANACNDVIEQLWKKEFTleFSRDRKSMSVYCSPTKASGgnKL 503
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  634 YSKGASEIILKKCSRILSEVGEPRVFRPRDRDEMVKKVIEpMACDGLRTICVGYRDFP-KDPEPNWEDENN---ILTDLT 709
Cdd:cd02083   504 FVKGAPEGVLERCTHVRVGGGKVVPLTAAIKILILKKVWG-YGTDTLRCLALATKDTPpKPEDMDLEDSTKfykYETDLT 582
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  710 AICVVGIEDPVRPEVPDAIQKCQRAGITVRMVTGDNINTARAIAIKCGIIHPGEDFLcidGKEFNRRIRNEKGEVEQEri 789
Cdd:cd02083   583 FVGVVGMLDPPRPEVRDSIEKCRDAGIRVIVITGDNKGTAEAICRRIGIFGEDEDTT---GKSYTGREFDDLSPEEQR-- 657
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  790 dKVWPKLRVLARSSPTDKHTLVKgiidsTLVDQRQVVAVTGDGTNDGPALKKADVGFAMGIaGTDVAKEASDIILTDDNF 869
Cdd:cd02083   658 -EACRRARLFSRVEPSHKSKIVE-----LLQSQGEITAMTGDGVNDAPALKKAEIGIAMGS-GTAVAKSASDMVLADDNF 730
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  870 SSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTFASLALATEPPTESLLMRK 949
Cdd:cd02083   731 ATIVAAVEEGRAIYNNMKQFIRYLISSNIGEVVSIFLTAALGLPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMKKP 810
                         970
                  ....*....|.
gi 181339464  950 PYGRNKPLISS 960
Cdd:cd02083   811 PRKPDEPLISG 821
ATPase-IIA1_Ca TIGR01116
sarco/endoplasmic reticulum calcium-translocating P-type ATPase; This model describes the ...
96-1076 2.94e-114

sarco/endoplasmic reticulum calcium-translocating P-type ATPase; This model describes the P-type ATPase responsible for translocating calcium ions across the endoplasmic reticulum membrane of eukaryotes, and is of particular importance in the sarcoplasmic reticulum of skeletal and cardiac muscle in vertebrates. These pumps transfer Ca2+ from the cytoplasm to the lumen of the endoplasmic reticulum. In humans and mice, at least, there are multiple isoforms of the SERCA pump with overlapping but not redundant functions. Defects in SERCA isoforms are associated with diseases in humans. The calcium P-type ATPases have been characterized as Type IIA based on a phylogenetic analysis which distinguishes this group from the Type IIB PMCA calcium pump modelled by TIGR01517. A separate analysis divides Type IIA into sub-types, SERCA and PMR1, the latter of which is modelled by TIGR01522. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273452 [Multi-domain]  Cd Length: 917  Bit Score: 379.51  E-value: 2.94e-114
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464    96 VWEALQDVTLIILEIAALISLGLSFYqppgegntdacgdakagaEDEGESEAGWIEGAAILLSVVCVVLVTAFNDWSKEK 175
Cdd:TIGR01116    1 VLEQFEDLLVRILLLAACVSFVLAWF------------------EEGEETVTAFVEPFVILLILVANAIVGVWQERNAEK 62
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   176 QFRGLQSrIEQEQKfQVVRGGQVIQLPVADILVGDIAQIKYGDLLPADGVLIQGNDLKIDESSLTGESDHVRKAA----- 250
Cdd:TIGR01116   63 AIEALKE-YESEHA-KVLRDGRWSVIKAKDLVPGDIVELAVGDKVPADIRVLSLKTLRVDQSILTGESVSVNKHTesvpd 140
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   251 ------DKDPMLLSGTHVMEGSGRMVVTAVGVNSQSGiiftllgaggeeeekkekkgqaledghplpdcshpsshpiati 324
Cdd:TIGR01116  141 eravnqDKKNMLFSGTLVVAGKARGVVVRTGMSTEIG------------------------------------------- 177
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   325 atdgaasantpantslvngkmqdgnmennqtKVKKQDGAAAmemqplksaeggeteekekkktsvskKEKSVLQGKLTKL 404
Cdd:TIGR01116  178 -------------------------------KIRDEMRAAE--------------------------QEDTPLQKKLDEF 200
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   405 AVQIGKAGLVMSAITVIILVLYFaiDTFVRQKRpwltectpiYIQYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKK 484
Cdd:TIGR01116  201 GELLSKVIGLICILVWVINIGHF--NDPALGGG---------WIQGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRK 269
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   485 MMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTAVQVYVAD----------VHYKTI-PEPTSLPSKTLDILVNAI 553
Cdd:TIGR01116  270 MAKKNAIVRKLPSVETLGCTTVICSDKTGTLTTNQMSVCKVVALDpsssslnefcVTGTTYaPEGGVIKDDGPVAGGQDA 349
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   554 SLNSAYTTKILPAD------KEGGLPKQVGNKTECGFLGLV-----------LDVKRDYQTIRNQIPEEKLYKVYT--FN 614
Cdd:TIGR01116  350 GLEELATIAALCNDssldfnERKGVYEKVGEATEAALKVLVekmglpatkngVSSKRRPALGCNSVWNDKFKKLATleFS 429
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   615 SVRKSMSTVIKlPDGSFRMYSKGASEIILKKCSRILSEVGEPRVFRPRDRDEMVKKVIEPMACDGLRTICVGYRDFP-KD 693
Cdd:TIGR01116  430 RDRKSMSVLCK-PSTGNKLFVKGAPEGVLERCTHILNGDGRAVPLTDKMKNTILSVIKEMGTTKALRCLALAFKDIPdPR 508
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   694 PEPNWEDENN---ILTDLTAICVVGIEDPVRPEVPDAIQKCQRAGITVRMVTGDNINTARAIAIKCGIIHPGEDFLCID- 769
Cdd:TIGR01116  509 EEDLLSDPANfeaIESDLTFIGVVGMLDPPRPEVADAIEKCRTAGIRVIMITGDNKETAEAICRRIGIFSPDEDVTFKSf 588
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   770 -GKEFNrrirnekgEVEQERIDKVWPKLRVLARSSPTDKHTLVKgiidsTLVDQRQVVAVTGDGTNDGPALKKADVGFAM 848
Cdd:TIGR01116  589 tGREFD--------EMGPAKQRAACRSAVLFSRVEPSHKSELVE-----LLQEQGEIVAMTGDGVNDAPALKKADIGIAM 655
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   849 GiAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIM 928
Cdd:TIGR01116  656 G-SGTEVAKEASDMVLADDNFATIVAAVEEGRAIYNNMKQFIRYMISSNIGEVVCIFLTAALGIPEGLIPVQLLWVNLVT 734
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   929 DTFASLALATEPPTESLLMRKPYGRNKPLISSTMTKNILGHGVY-----QLVIIFSLLFVGEQIFDIDSGRNAP------ 997
Cdd:TIGR01116  735 DGLPATALGFNPPDKDIMWKPPRRPDEPLITGWLFFRYLVVGVYvglatVGGFVWWYLLTHFTGCDEDSFTTCPdfedpd 814
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   998 --LHSPPSEHYTIIFNTFVMMQLFNEINARKIHGERNVFdGIFRNPIFCSIVVGTFAIQIVI--VQFGGKPFSCSPLDLE 1073
Cdd:TIGR01116  815 cyVFEGKQPARTISLSVLVVIEMFNALNALSEDQSLLRM-PPWVNKWLIGAICLSMALHFLIlyVPFLSRIFGVTPLSLT 893

                   ...
gi 181339464  1074 KWM 1076
Cdd:TIGR01116  894 DWL 896
P-type_ATPase_Na_ENA cd02086
fungal-type Na(+)-ATPase, similar to the plasma membrane sodium transporters Saccharomyces ...
149-1057 2.94e-105

fungal-type Na(+)-ATPase, similar to the plasma membrane sodium transporters Saccharomyces cerevisiae Ena1p, Ena2p and Ustilago maydis Ena1, and the endoplasmic reticulum sodium transporter Ustilago maydis Ena2; Fungal-type Na(+)-ATPase (also called ENA ATPases). This subfamily includes the Saccharomyces cerevisiae plasma membrane transporters: Na(+)/Li(+)-exporting ATPase Ena1p which may also extrudes K(+), and Na(+)-exporting P-type ATPase Ena2p. It also includes Ustilago maydis plasma membrane Ena1, an K(+)/Na(+)-ATPase whose chief role is to pump Na(+) and K(+) out of the cytoplasm, especially at high pH values, and endoplasmic reticulum Ena2 ATPase which mediates Na(+) or K(+) fluxes in the ER or in other endomembranes. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319780 [Multi-domain]  Cd Length: 920  Bit Score: 354.84  E-value: 2.94e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  149 WIEGAAILLSVVCVVLVTAFNDWSKEKQFRGLQSRIEQEQKfqVVRGGQVIQLPVADILVGDIAQIKYGDLLPADGVLIQ 228
Cdd:cd02086    56 WIEGGVIAAVIALNVIVGFIQEYKAEKTMDSLRNLSSPNAH--VIRSGKTETISSKDVVPGDIVLLKVGDTVPADLRLIE 133
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  229 GNDLKIDESSLTGESDHVRKAA-------------DKDPMLLSGTHVMEGSGRMVVTAVGVNSQSGIIFTLLGaggeeee 295
Cdd:cd02086   134 TKNFETDEALLTGESLPVIKDAelvfgkeedvsvgDRLNLAYSSSTVTKGRAKGIVVATGMNTEIGKIAKALR------- 206
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  296 kkekkgqaledghplpdcshpsshpiatiatdgaasantpantslvngkmQDGNMENNQTKVKKQDGAAamemqplksae 375
Cdd:cd02086   207 --------------------------------------------------GKGGLISRDRVKSWLYGTL----------- 225
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  376 ggeTEEKEKKKTSVSKKEKSVLQGKLTKLAVqigkaglVMSAITVIILVLYFAIDTFVRQKRpwltectpiyiqyfvkFF 455
Cdd:cd02086   226 ---IVTWDAVGRFLGTNVGTPLQRKLSKLAY-------LLFFIAVILAIIVFAVNKFDVDNE----------------VI 279
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  456 IIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTAVQVYVadvhykti 535
Cdd:cd02086   280 IYAIALAISMIPESLVAVLTITMAVGAKRMVKRNVIVRKLDALEALGAVTDICSDKTGTLTQGKMVVRQVWI-------- 351
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  536 pePTSLpsktldilvnaisLNSAYTTKilpaDKEGGLPKQVGNKTECGFLGLV--LDVKRDYQTIRNQiPEEKLYKVYTF 613
Cdd:cd02086   352 --PAAL-------------CNIATVFK----DEETDCWKAHGDPTEIALQVFAtkFDMGKNALTKGGS-AQFQHVAEFPF 411
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  614 NSVRKSMSTVIK-LPDGSFRMYSKGASEIILKKCSRILSEVGEPRVFRPrDRDEMVKKViEPMACDGLRTICVGYRDFPK 692
Cdd:cd02086   412 DSTVKRMSVVYYnNQAGDYYAYMKGAVERVLECCSSMYGKDGIIPLDDE-FRKTIIKNV-ESLASQGLRVLAFASRSFTK 489
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  693 DpEPNWEDENNILT-------DLTAICVVGIEDPVRPEVPDAIQKCQRAGITVRMVTGDNINTARAIAIKCGIIHPGE-- 763
Cdd:cd02086   490 A-QFNDDQLKNITLsradaesDLTFLGLVGIYDPPRNESAGAVEKCHQAGITVHMLTGDHPGTAKAIAREVGILPPNSyh 568
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  764 ------DFLCIDGKEFNRrirnekgeVEQERIDKVwPKL-RVLARSSPTDKhtlVKGIidSTLVDQRQVVAVTGDGTNDG 836
Cdd:cd02086   569 ysqeimDSMVMTASQFDG--------LSDEEVDAL-PVLpLVIARCSPQTK---VRMI--EALHRRKKFCAMTGDGVNDS 634
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  837 PALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDS-- 914
Cdd:cd02086   635 PSLKMADVGIAMGLNGSDVAKDASDIVLTDDNFASIVNAIEEGRRMFDNIQKFVLHLLAENVAQVILLLIGLAFKDEDgl 714
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  915 ---PLKAVQMLWVNLIMDTFASLALATEPPTESLLMRKPYGRNKPLISSTMTKNILGHGVYQLVIIFsLLFVGeQIFDID 991
Cdd:cd02086   715 svfPLSPVEILWINMVTSSFPAMGLGLEKASPDVMQRPPHDLKVGIFTRELIIDTFVYGTFMGVLCL-ASFTL-VIYGIG 792
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  992 SGRnapLHSPPSEHYTI-----------IFNTFVMMQLF---NEINARK----IHGE-----RNVFDGIFRNP-IFCSIV 1047
Cdd:cd02086   793 NGD---LGSDCNESYNSscedvfraraaVFATLTWCALIlawEVVDMRRsffnMHPDtdspvKSFFKTLWKNKfLFWSVV 869
                         970
                  ....*....|
gi 181339464 1048 VGTFAIQIVI 1057
Cdd:cd02086   870 LGFVSVFPTL 879
P-type_ATPase_SPCA cd02085
golgi-associated secretory pathway Ca(2+) transport ATPases, similar to human ATPase secretory ...
192-1060 9.33e-105

golgi-associated secretory pathway Ca(2+) transport ATPases, similar to human ATPase secretory pathway Ca(2+) transporting 1/hSPCA1 and Saccharomyces cerevisiae Ca(2+)/Mn(2+)-transporting P-type ATPase, Pmr1p; SPCAs are Ca(2+) pumps important for the golgi-associated secretion pathway, in addition some function as Mn(2+) pumps in Mn(2+) detoxification. Saccharomyces cerevisiae Pmr1p is a high affinity Ca(2+)/Mn(2+) ATPase which transports Ca(2+) and Mn(2+) from the cytoplasm into the Golgi. Pmr1p also contributes to Cd(2+) detoxification. This subfamily includes human SPCA1 and SPCA2, encoded by the ATP2C1 and ATP2C2 genes; autosomal dominant Hailey-Hailey disease is caused by mutations in the human ATP2C1 gene. It also includes Strongylocentrotus purpuratus testis secretory pathway calcium transporting ATPase SPCA which plays an important role in fertilization. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319779 [Multi-domain]  Cd Length: 804  Bit Score: 350.16  E-value: 9.33e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  192 VVRGGQVIQLPVADILVGDIAQIKYGDLLPADGVLIQGNDLKIDESSLTGESDHVRK-------AADKDPMLLS-----G 259
Cdd:cd02085    88 CLRDGKLEHFLARELVPGDLVCLSIGDRIPADLRLFEATDLSIDESSLTGETEPCSKttevipkASNGDLTTRSniafmG 167
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  260 THVMEGSGRMVVTAVGVNSQSGIIFtllgaggeeeekkekkgqaledghplpdcshpsshpiatiatdgaasantpants 339
Cdd:cd02085   168 TLVRCGHGKGIVIGTGENSEFGEVF------------------------------------------------------- 192
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  340 lvngKMqdgnmennqtkvkkqdgaaameMQplksaeggeteekekkktsVSKKEKSVLQGKLTKLAVQigkaglvMSAIT 419
Cdd:cd02085   193 ----KM----------------------MQ-------------------AEEAPKTPLQKSMDKLGKQ-------LSLYS 220
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  420 VIILVLYFAIDTFvrQKRPWLtectpiyiqyfvKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACE 499
Cdd:cd02085   221 FIIIGVIMLIGWL--QGKNLL------------EMFTIGVSLAVAAIPEGLPIVVTVTLALGVMRMAKRRAIVKKLPIVE 286
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  500 TMGNATAICSDKTGTLTTNRMTAVQVYVADVHYKTIPEPTSLPSKTLDILVNAISLNSayttkilpadkegGLPkqvgnk 579
Cdd:cd02085   287 TLGCVNVICSDKTGTLTKNEMTVTKIVTGCVCNNAVIRNNTLMGQPTEGALIALAMKM-------------GLS------ 347
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  580 tecgflglvlDVKRDYQTIRNqipeeklykvYTFNSVRKSMSTVIKLPDGSFR---MYSKGASEIILKKCSRILSEVGEP 656
Cdd:cd02085   348 ----------DIRETYIRKQE----------IPFSSEQKWMAVKCIPKYNSDNeeiYFMKGALEQVLDYCTTYNSSDGSA 407
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  657 RVFRPRDRDEmVKKVIEPMACDGLRTICvgyrdFPKDPEpnwedenniLTDLTAICVVGIEDPVRPEVPDAIQKCQRAGI 736
Cdd:cd02085   408 LPLTQQQRSE-INEEEKEMGSKGLRVLA-----LASGPE---------LGDLTFLGLVGINDPPRPGVREAIQILLESGV 472
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  737 TVRMVTGDNINTARAIAIKCGIIHPGEdfLCIDGKEFNRrirnekgeVEQERIDKVWPKLRVLARSSPTDKHTLVKGIID 816
Cdd:cd02085   473 RVKMITGDAQETAIAIGSSLGLYSPSL--QALSGEEVDQ--------MSDSQLASVVRKVTVFYRASPRHKLKIVKALQK 542
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  817 STLVdqrqvVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTV 896
Cdd:cd02085   543 SGAV-----VAMTGDGVNDAVALKSADIGIAMGRTGTDVCKEAADMILVDDDFSTILAAIEEGKGIFYNIKNFVRFQLST 617
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  897 NVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTFASLALATEPPTESLLMRKPYGRNKPLISSTMTKNILghgVYQLVI 976
Cdd:cd02085   618 SIAALSLIALSTLFNLPNPLNAMQILWINIIMDGPPAQSLGVEPVDKDVIRQPPRNVKDPILTRSLILNVL---LSAAII 694
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  977 IFSLLFVgeqiF--DIDSGRNAPLHSppsehyTIIFNTFVMMQLFNEINARkiHGERNVFD-GIFRNPIFCSIVVGTFAI 1053
Cdd:cd02085   695 VSGTLWV----FwkEMSDDNVTPRDT------TMTFTCFVFFDMFNALSCR--SQTKSIFEiGFFSNRMFLYAVGGSLIG 762

                  ....*..
gi 181339464 1054 QIVIVQF 1060
Cdd:cd02085   763 QLLVIYF 769
P-type_ATPases cd01431
ATP-dependent membrane-bound cation and aminophospholipid transporters; The P-type ATPases, ...
507-936 5.88e-96

ATP-dependent membrane-bound cation and aminophospholipid transporters; The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd(2+), and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.


Pssm-ID: 319764 [Multi-domain]  Cd Length: 319  Bit Score: 309.77  E-value: 5.88e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  507 ICSDKTGTLTTNRMTAVQVYVadvhyktipeptslpsktldilvnaislnsayttkilpadkegglpkqvgnktecgflg 586
Cdd:cd01431     2 ICSDKTGTLTKNGMTVTKLFI----------------------------------------------------------- 22
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  587 lvldvkrdyqtirnqipeeklyKVYTFNSVRKSMSTVIKLPdGSFRMYSKGASEIILKKCSRILSEvgeprvfrprDRDE 666
Cdd:cd01431    23 ----------------------EEIPFNSTRKRMSVVVRLP-GRYRAIVKGAPETILSRCSHALTE----------EDRN 69
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  667 MVKKVIEPMACDGLRTICVGYRDFPKDPepnweDENNILTDLTAICVVGIEDPVRPEVPDAIQKCQRAGITVRMVTGDNI 746
Cdd:cd01431    70 KIEKAQEESAREGLRVLALAYREFDPET-----SKEAVELNLVFLGLIGLQDPPRPEVKEAIAKCRTAGIKVVMITGDNP 144
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  747 NTARAIAIKCGIIHPGEDFLCIDgkefnrrirnEKGEVEQERIDKVWPKLRVLARSSPTDKHTLVKGiidstLVDQRQVV 826
Cdd:cd01431   145 LTAIAIAREIGIDTKASGVILGE----------EADEMSEEELLDLIAKVAVFARVTPEQKLRIVKA-----LQARGEVV 209
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  827 AVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFT 906
Cdd:cd01431   210 AMTGDGVNDAPALKQADVGIAMGSTGTDVAKEAADIVLLDDNFATIVEAVEEGRAIYDNIKKNITYLLANNVAEVFAIAL 289
                         410       420       430
                  ....*....|....*....|....*....|
gi 181339464  907 GACITQDSPLKAVQMLWVNLIMDTFASLAL 936
Cdd:cd01431   290 ALFLGGPLPLLAFQILWINLVTDLIPALAL 319
P-type_ATPase cd07539
uncharacterized subfamily of P-type ATPase transporters; This subfamily contains P-type ATPase ...
174-939 2.17e-84

uncharacterized subfamily of P-type ATPase transporters; This subfamily contains P-type ATPase transporters of unknown function. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd2+, and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.


Pssm-ID: 319840 [Multi-domain]  Cd Length: 634  Bit Score: 288.93  E-value: 2.17e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  174 EKQFRGLqsRIEQEQKFQVVR--GGQVIQLPVADILVGDIAQIKYGDLLPADGVLIQGNDLKIDESSLTGESDHVRKA-- 249
Cdd:cd07539    82 ERALAAL--LAQQQQPARVVRapAGRTQTVPAESLVPGDVIELRAGEVVPADARLLEADDLEVDESALTGESLPVDKQva 159
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  250 -------ADKDPMLLSGTHVMEGSGRMVVTAVGVNSQSGIIFTLLgaggeeeekkekkgqaledghplpdcshpsshpia 322
Cdd:cd07539   160 ptpgaplADRACMLYEGTTVVSGQGRAVVVATGPHTEAGRAQSLV----------------------------------- 204
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  323 tiatdGAASANTPANTSLvngkmqdgnmennqtkvkkqdgaaamemqplksaeggeteekekkktsvskkeksvlqGKLT 402
Cdd:cd07539   205 -----APVETATGVQAQL----------------------------------------------------------RELT 221
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  403 K--LAVQIGKAGLVmsaitviilvlyFAIDtfVRQKRPWLTectpiyiqyFVKffiIGVTVLVVAVPEGLPLAVTISLAY 480
Cdd:cd07539   222 SqlLPLSLGGGAAV------------TGLG--LLRGAPLRQ---------AVA---DGVSLAVAAVPEGLPLVATLAQLA 275
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  481 SVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTAVQVyvadvhyktipeptslpsktldilvnaislnsayt 560
Cdd:cd07539   276 AARRLSRRGVLVRSPRTVEALGRVDTICFDKTGTLTENRLRVVQV----------------------------------- 320
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  561 tkilpADKEGGLPkqvgnktecgflglvldvkrdyqtirnqipeeklykvytFNSVRKSMSTVIKLPDGSFRMYSKGASE 640
Cdd:cd07539   321 -----RPPLAELP---------------------------------------FESSRGYAAAIGRTGGGIPLLAVKGAPE 356
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  641 IILKKCSRILSevGEPRVFRPRDRDEMVKKVIEPMACDGLRTICVGYRDFPKDPEPNWEDENNiltDLTAICVVGIEDPV 720
Cdd:cd07539   357 VVLPRCDRRMT--GGQVVPLTEADRQAIEEVNELLAGQGLRVLAVAYRTLDAGTTHAVEAVVD---DLELLGLLGLADTA 431
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  721 RPEVPDAIQKCQRAGITVRMVTGDNINTARAIAIKCGIihpGEDFLCIDGKEFNRRIRNEKgEVEQERIDkvwpklrVLA 800
Cdd:cd07539   432 RPGAAALIAALHDAGIDVVMITGDHPITARAIAKELGL---PRDAEVVTGAELDALDEEAL-TGLVADID-------VFA 500
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  801 RSSPTDKHTLVkgiidSTLVDQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGR 880
Cdd:cd07539   501 RVSPEQKLQIV-----QALQAAGRVVAMTGDGANDAAAIRAADVGIGVGARGSDAAREAADLVLTDDDLETLLDAVVEGR 575
                         730       740       750       760       770
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 181339464  881 NVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTFASLALATE 939
Cdd:cd07539   576 TMWQNVRDAVHVLLGGNLGEVMFTLIGTAIGGGAPLNTRQLLLVNLLTDMFPALALAVE 634
P-type_ATPase_Na-K_like cd02608
alpha-subunit of Na(+)/K(+)-ATPases and of gastric H(+)/K(+)-ATPase, similar to the human Na(+) ...
188-959 1.49e-83

alpha-subunit of Na(+)/K(+)-ATPases and of gastric H(+)/K(+)-ATPase, similar to the human Na(+)/K(+)-ATPase alpha subunits 1-4; This subfamily includes the alpha subunit of Na(+)/K(+)-ATPase a heteromeric transmembrane protein composed of an alpha- and beta-subunit and an optional third subunit belonging to the FXYD proteins which are more tissue specific regulatory subunits of the enzyme. The alpha-subunit is the catalytic subunit responsible for transport activities of the enzyme. This subfamily includes all four isotopes of the human alpha subunit: (alpha1-alpha4, encoded by the ATP1A1- ATP1A4 genes). Na(+)/K(+)-ATPase functions chiefly as an ion pump, hydrolyzing one molecule of ATP to pump three Na(+) out of the cell in exchange for two K(+)entering the cell per pump cycle. In addition Na(+)/K(+)-ATPase acts as a signal transducer. This subfamily also includes Oreochromis mossambicus (tilapia) Na(+)/K(+)-ATPase alpha 1 and alpha 3 subunits, and gastric H(+)/K(+)-ATPase which exchanges hydronium ion with potassium and is responsible for gastric acid secretion. Gastric H(+)/K(+)-ATPase is an alpha,beta-heterodimeric enzyme. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319794 [Multi-domain]  Cd Length: 905  Bit Score: 293.10  E-value: 1.49e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  188 QKFQVVRGGQVIQLPVADILVGDIAQIKYGDLLPADGVLIQGNDLKIDESSLTGESDHVRKAAD---KDPM------LLS 258
Cdd:cd02608   106 QQALVIRDGEKMQINAEELVVGDLVEVKGGDRIPADIRIISAHGCKVDNSSLTGESEPQTRSPEfthENPLetkniaFFS 185
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  259 gTHVMEGSGRMVVTAVGVNSQSGiiftllgaggeeeekkekkgqaledghplpdcshpsshPIATIATdgaasantpant 338
Cdd:cd02608   186 -TNCVEGTARGIVINTGDRTVMG--------------------------------------RIATLAS------------ 214
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  339 SLVNGKmqdgnmennqtkvkkqdgaaamemqplksaeggeteekekkktsvskkeksvlqgklTKLAVQIGKAGLVMSAI 418
Cdd:cd02608   215 GLEVGK---------------------------------------------------------TPIAREIEHFIHIITGV 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  419 TVIILVLYFAIDTFVrqKRPWLTECtpiyiqyfvkFFIIGVtvlVVA-VPEGLPLAVTISLAYSVKKMMKDNNLVRHLDA 497
Cdd:cd02608   238 AVFLGVSFFILSLIL--GYTWLEAV----------IFLIGI---IVAnVPEGLLATVTVCLTLTAKRMARKNCLVKNLEA 302
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  498 CETMGNATAICSDKTGTLTTNRMTAV------QVYVADV--------HYKTipeptslpSKTLDILVNAISL-NSAyttK 562
Cdd:cd02608   303 VETLGSTSTICSDKTGTLTQNRMTVAhmwfdnQIHEADTtedqsgasFDKS--------SATWLALSRIAGLcNRA---E 371
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  563 ILPADKEGGLPKQV--GNKTECGFL-------GLVLDVKRDYQTIrNQIPeeklykvytFNSVRK---SMSTVIKLPDGS 630
Cdd:cd02608   372 FKAGQENVPILKRDvnGDASESALLkcielscGSVMEMRERNPKV-AEIP---------FNSTNKyqlSIHENEDPGDPR 441
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  631 FRMYSKGASEIILKKCSRILSEVGEprvfrpRDRDEMVKKVIEP--MACDGLRTICVGYRD-------FPKDPEPNWEDE 701
Cdd:cd02608   442 YLLVMKGAPERILDRCSTILINGKE------QPLDEEMKEAFQNayLELGGLGERVLGFCHlylpddkFPEGFKFDTDEV 515
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  702 NNILTDLtaiCVVGIE---DPVRPEVPDAIQKCQRAGITVRMVTGDNINTARAIAIKCGIIhpgedflcidgkefnrrir 778
Cdd:cd02608   516 NFPTENL---CFVGLMsmiDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGII------------------- 573
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  779 nekgeveqeridkvwpklrVLARSSPTDKHTLVKGIidstlvdQRQ--VVAVTGDGTNDGPALKKADVGFAMGIAGTDVA 856
Cdd:cd02608   574 -------------------VFARTSPQQKLIIVEGC-------QRQgaIVAVTGDGVNDSPALKKADIGVAMGIAGSDVS 627
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  857 KEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNvVAVIVAFTgACITQDSPLK--AVQMLWVNLIMDTFASL 934
Cdd:cd02608   628 KQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSN-IPEITPFL-IFIIANIPLPlgTITILCIDLGTDMVPAI 705
                         810       820       830
                  ....*....|....*....|....*....|.
gi 181339464  935 ALATEPPTESLLMRKP----YGR--NKPLIS 959
Cdd:cd02608   706 SLAYEKAESDIMKRQPrnpkTDKlvNERLIS 736
P-type_ATPase cd07538
uncharacterized subfamily of P-type ATPase transporters; This subfamily contains P-type ATPase ...
74-973 5.30e-82

uncharacterized subfamily of P-type ATPase transporters; This subfamily contains P-type ATPase transporters of unknown function. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd2+, and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.


Pssm-ID: 319839 [Multi-domain]  Cd Length: 653  Bit Score: 282.79  E-value: 5.30e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   74 KRKEVFGRNLIPPKKPKTFLQLVWEALQDVTLIILEIAALISLGLsfyqppgegntdacGDAKagaedegeseagwiEGA 153
Cdd:cd07538     9 RRLESGGKNELPQPKKRTLLASILDVLREPMFLLLLAAALIYFVL--------------GDPR--------------EGL 60
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  154 AILLSVVCVVLVTAFNDWSKEKQFRGLqsRIEQEQKFQVVRGGQVIQLPVADILVGDIAQIKYGDLLPADGVLIQGNDLK 233
Cdd:cd07538    61 ILLIFVVVIIAIEVVQEWRTERALEAL--KNLSSPRATVIRDGRERRIPSRELVPGDLLILGEGERIPADGRLLENDDLG 138
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  234 IDESSLTGESDHVRKAAD----------KDPMLLSGTHVMEGSGRMVVTAVGVNSQSGIIftllgaggeeeekkekkgqa 303
Cdd:cd07538   139 VDESTLTGESVPVWKRIDgkamsapggwDKNFCYAGTLVVRGRGVAKVEATGSRTELGKI-------------------- 198
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  304 ledghplpdcshpsshpiatiatdgaasantpantslvnGKMQDGnMENNQTKVKKQdgaaamemqplksaeggeteeke 383
Cdd:cd07538   199 ---------------------------------------GKSLAE-MDDEPTPLQKQ----------------------- 215
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  384 kkktsvskkeksvlQGKLTKLavqIGKAGLVMSAITVIilvLYFaidtfvrqkrpwltectpIYIQYFVKFFIIGVTVLV 463
Cdd:cd07538   216 --------------TGRLVKL---CALAALVFCALIVA---VYG------------------VTRGDWIQAILAGITLAM 257
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  464 VAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTAVQVYVadvhyktipeptslps 543
Cdd:cd07538   258 AMIPEEFPVILTVFMAMGAWRLAKKNVLVRRAAAVETLGSITVLCVDKTGTLTKNQMEVVELTS---------------- 321
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  544 ktldilvnaislnsayttkilpadkegglpkqvgnktecgflglvldvkrdyqtirnqipeekLYKVYTFNSVRKSMSTV 623
Cdd:cd07538   322 ---------------------------------------------------------------LVREYPLRPELRMMGQV 338
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  624 IKLPDGSFrMYSKGASEIILKKCSrilsevgeprvFRPRDRDEMVKKVIEpMACDGLRTICVGYRDFPKDPEPNwedenn 703
Cdd:cd07538   339 WKRPEGAF-AAAKGSPEAIIRLCR-----------LNPDEKAAIEDAVSE-MAGEGLRVLAVAACRIDESFLPD------ 399
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  704 ILTDLTAICV--VGIEDPVRPEVPDAIQKCQRAGITVRMVTGDNINTARAIAIKCGIIH-----PGEDFLCIDGKEFNRR 776
Cdd:cd07538   400 DLEDAVFIFVglIGLADPLREDVPEAVRICCEAGIRVVMITGDNPATAKAIAKQIGLDNtdnviTGQELDAMSDEELAEK 479
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  777 IRNekgeveqeridkvwpkLRVLARSSPTDKHTLVKGiidstLVDQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVA 856
Cdd:cd07538   480 VRD----------------VNIFARVVPEQKLRIVQA-----FKANGEIVAMTGDGVNDAPALKAAHIGIAMGKRGTDVA 538
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  857 KEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTFASLAL 936
Cdd:cd07538   539 REASDIVLLDDNFSSIVSTIRLGRRIYDNLKKAITYVFAIHVPIAGLALLPPLLGLPPLLFPVHVVLLELIIDPTCSIVF 618
                         890       900       910
                  ....*....|....*....|....*....|....*..
gi 181339464  937 ATEPPTESLLMRKPYGRNKPLISStmtkNILGHGVYQ 973
Cdd:cd07538   619 EAEPAERDIMRRPPRPPDEPLFGP----RLVIKAILQ 651
ATPase-IIC_X-K TIGR01106
sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit; This ...
188-959 9.57e-80

sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit; This model describes the P-type ATPases responsible for the exchange of either protons or sodium ions for potassium ions across the plasma membranes of eukaryotes. Unlike most other P-type ATPases, members of this subfamily require a beta subunit for activity. This model encompasses eukaryotes and consists of two functional types, a Na/K antiporter found widely distributed in eukaryotes and a H/K antiporter found only in vertebrates. The Na+ or H+/K+ antiporter P-type ATPases have been characterized as Type IIC based on a published phylogenetic analysis. Sequences from Blastocladiella emersonii (GP|6636502, GP|6636502 and PIR|T43025), C. elegans (GP|2315419, GP|6671808 and PIR|T31763) and Drosophila melanogaster (GP|7291424) score below trusted cutoff, apparently due to long branch length (excessive divergence from the last common ancestor) as evidenced by a phylogenetic tree. Experimental evidence is needed to determine whether these sequences represent ATPases with conserved function. Aside from fragments, other sequences between trusted and noise appear to be bacterial ATPases of unclear lineage, but most likely calcium pumps. [Energy metabolism, ATP-proton motive force interconversion]


Pssm-ID: 273445 [Multi-domain]  Cd Length: 997  Bit Score: 283.99  E-value: 9.57e-80
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   188 QKFQVVRGGQVIQLPVADILVGDIAQIKYGDLLPADGVLIQGNDLKIDESSLTGESDHVRKAAD---KDPM-----LLSG 259
Cdd:TIGR01106  141 QQALVIRDGEKMSINAEQVVVGDLVEVKGGDRIPADLRIISAQGCKVDNSSLTGESEPQTRSPEfthENPLetrniAFFS 220
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   260 THVMEGSGRMVVTAVGVNSQSGiiftllgaggeeeekkekkgqaledghplpdcshpsshPIATIATdgaasantpants 339
Cdd:TIGR01106  221 TNCVEGTARGIVVNTGDRTVMG--------------------------------------RIASLAS------------- 249
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   340 lvngkmqdgNMENNQTKVkkqdgaaAMEMQPLKSAeggeteekekkktsvskkeksvlqgkLTKLAVQIGKAGLVMSAIt 419
Cdd:TIGR01106  250 ---------GLENGKTPI-------AIEIEHFIHI--------------------------ITGVAVFLGVSFFILSLI- 286
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   420 viilVLYFAIDTFVrqkrpwltectpiyiqyfvkfFIIGVtvLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACE 499
Cdd:TIGR01106  287 ----LGYTWLEAVI---------------------FLIGI--IVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVE 339
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   500 TMGNATAICSDKTGTLTTNRMTAV------QVYVADVHYKTIPEPTSLPSKTLDILVNAISLNSAYTTKilPADKEGGLP 573
Cdd:TIGR01106  340 TLGSTSTICSDKTGTLTQNRMTVAhmwfdnQIHEADTTEDQSGVSFDKSSATWLALSRIAGLCNRAVFK--AGQENVPIL 417
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   574 KQ--VGNKTECGFL-------GLVLDVKRDYQTIrNQIPeeklykvytFNSVRKSMSTVIKLPDGS---FRMYSKGASEI 641
Cdd:TIGR01106  418 KRavAGDASESALLkcielclGSVMEMRERNPKV-VEIP---------FNSTNKYQLSIHENEDPRdprHLLVMKGAPER 487
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   642 ILKKCSRILSEvGEPRVFrprdrDEMVKKVIEP--MACDGLRTICVGY-------RDFPKDPEPNWEDENNILTDLTAIC 712
Cdd:TIGR01106  488 ILERCSSILIH-GKEQPL-----DEELKEAFQNayLELGGLGERVLGFchlylpdEQFPEGFQFDTDDVNFPTDNLCFVG 561
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   713 VVGIEDPVRPEVPDAIQKCQRAGITVRMVTGDNINTARAIAIKCGIIHPG----EDF---LCIDGKEFNRRIRN------ 779
Cdd:TIGR01106  562 LISMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGnetvEDIaarLNIPVSQVNPRDAKacvvhg 641
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   780 -EKGEVEQERIDKVwpkLR-----VLARSSPTDKHTLVKGIidstlvdQRQ--VVAVTGDGTNDGPALKKADVGFAMGIA 851
Cdd:TIGR01106  642 sDLKDMTSEQLDEI---LKyhteiVFARTSPQQKLIIVEGC-------QRQgaIVAVTGDGVNDSPALKKADIGVAMGIA 711
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   852 GTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNV--VAVIVAFTGACITQdsPLKAVQMLWVNLIMD 929
Cdd:TIGR01106  712 GSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIpeITPFLIFIIANIPL--PLGTITILCIDLGTD 789
                          810       820       830
                   ....*....|....*....|....*....|....*.
gi 181339464   930 TFASLALATEPPTESLLMRKPYGR------NKPLIS 959
Cdd:TIGR01106  790 MVPAISLAYEKAESDIMKRQPRNPktdklvNERLIS 825
ATPase-IID_K-Na TIGR01523
potassium and/or sodium efflux P-type ATPase, fungal-type; Initially described as a calcium ...
57-994 6.43e-75

potassium and/or sodium efflux P-type ATPase, fungal-type; Initially described as a calcium efflux ATPase, more recent work has shown that the S. pombe CTA3 gene is in fact a potassium ion efflux pump. This model describes the clade of fungal P-type ATPases responsible for potassium and sodium efflux. The degree to which these pumps show preference for sodium or potassium varies. This group of ATPases has been classified by phylogentic analysis as type IID. The Leishmania sequence (GP|3192903), which falls between trusted and noise in this model, may very well turn out to be an active potassium pump.


Pssm-ID: 130586 [Multi-domain]  Cd Length: 1053  Bit Score: 270.73  E-value: 6.43e-75
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464    57 LKTSPTEGLAglATDLDKRKEVFGRNLIPPKKPKTFLQLVWEALQDVTLIILEIAALISLGLsfyqppgegnTDacgdak 136
Cdd:TIGR01523   19 IGTSIPEGLT--HDEAQHRLKEVGENRLEADSGIDAKAMLLHQVCNAMCMVLIIAAAISFAM----------HD------ 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   137 agaedegeseagWIEGAAILLSVVCVVLVTAFNDWSKEKQFRGLqsRIEQEQKFQVVRGGQVIQLPVADILVGDIAQIKY 216
Cdd:TIGR01523   81 ------------WIEGGVISAIIALNILIGFIQEYKAEKTMDSL--KNLASPMAHVIRNGKSDAIDSHDLVPGDICLLKT 146
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   217 GDLLPADGVLIQGNDLKIDESSLTGESDHVRKAA-------------DKDPMLLSGTHVMEGSGRMVVTAVGVNSQSGII 283
Cdd:TIGR01523  147 GDTIPADLRLIETKNFDTDEALLTGESLPVIKDAhatfgkeedtpigDRINLAFSSSAVTKGRAKGICIATALNSEIGAI 226
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   284 FTLLGAGGEEEEKkekkgqaledghplPDCSHPSShpiatiatdgAASANT--PANTSLVNGKMQDGNMennqtkvkkqd 361
Cdd:TIGR01523  227 AAGLQGDGGLFQR--------------PEKDDPNK----------RRKLNKwiLKVTKKVTGAFLGLNV----------- 271
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   362 gaaamemqplksaeggeteekekkktsvskkeKSVLQGKLTKLAVqigkaglVMSAITVIILVLYFAIDTFVRQKRpwlt 441
Cdd:TIGR01523  272 --------------------------------GTPLHRKLSKLAV-------ILFCIAIIFAIIVMAAHKFDVDKE---- 308
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   442 ecTPIYiqyfvkffiiGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMT 521
Cdd:TIGR01523  309 --VAIY----------AICLAISIIPESLIAVLSITMAMGAANMSKRNVIVRKLDALEALGAVNDICSDKTGTITQGKMI 376
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   522 AVQVYVADVHY----------------------------------------------KTIPEPTSLPSKTLDILVNAISL 555
Cdd:TIGR01523  377 ARQIWIPRFGTisidnsddafnpnegnvsgiprfspyeyshneaadqdilkefkdelKEIDLPEDIDMDLFIKLLETAAL 456
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   556 NSAYTTKilpADKEGGLPKQVGNKTECGFLglVLDVKRDYQ---------------------TIRNQIPEEKLYKV---Y 611
Cdd:TIGR01523  457 ANIATVF---KDDATDCWKAHGDPTEIAIH--VFAKKFDLPhnaltgeedllksnendqsslSQHNEKPGSAQFEFiaeF 531
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   612 TFNSVRKSMSTVIKLPDG-SFRMYSKGASEIILKKCSRILSEVGEPRVFRPRDRDEMVKKVIEPMACDGLRTICVGYRDF 690
Cdd:TIGR01523  532 PFDSEIKRMASIYEDNHGeTYNIYAKGAFERIIECCSSSNGKDGVKISPLEDCDRELIIANMESLAAEGLRVLAFASKSF 611
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   691 PKDPepNWEDENNILT--------DLTAICVVGIEDPVRPEVPDAIQKCQRAGITVRMVTGDNINTARAIAIKCGII--- 759
Cdd:TIGR01523  612 DKAD--NNDDQLKNETlnrataesDLEFLGLIGIYDPPRNESAGAVEKCHQAGINVHMLTGDFPETAKAIAQEVGIIppn 689
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   760 -----HPGEDFLCIDGKEFNrrirnekgEVEQERIDKVWPKLRVLARSSPTDKHTLVKGiidstLVDQRQVVAVTGDGTN 834
Cdd:TIGR01523  690 fihdrDEIMDSMVMTGSQFD--------ALSDEEVDDLKALCLVIARCAPQTKVKMIEA-----LHRRKAFCAMTGDGVN 756
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   835 DGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDS 914
Cdd:TIGR01523  757 DSPSLKMANVGIAMGINGSDVAKDASDIVLSDDNFASILNAIEEGRRMFDNIMKFVLHLLAENVAEAILLIIGLAFRDEN 836
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   915 -----PLKAVQMLWVNLIMDTFASLALATEPPTESLLMRKPYGRNKPLISSTMTKNILGHGVYqLVIIFSLLFVGeQIFD 989
Cdd:TIGR01523  837 gksvfPLSPVEILWCIMITSCFPAMGLGLEKAAPDLMDRLPHDNEVGIFQKELIIDMFAYGFF-LGGSCLASFTG-ILYG 914

                   ....*
gi 181339464   990 IDSGR 994
Cdd:TIGR01523  915 FGSGN 919
P-type_ATPase_H cd02076
plant and fungal plasma membrane H(+)-ATPases, and related bacterial and archaeal putative H(+) ...
67-938 3.11e-68

plant and fungal plasma membrane H(+)-ATPases, and related bacterial and archaeal putative H(+)-ATPases; This subfamily includes eukaryotic plasma membrane H(+)-ATPase which transports H(+) from the cytosol to the extracellular space, thus energizing the plasma membrane for the uptake of ions and nutrients, and is expressed in plants and fungi. This H(+)-ATPase consists of four domains: a transmembrane domain and three cytosolic domains: nucleotide-binding domain, phosphorylation domain and actuator domain, and belongs to the P-type ATPase type III subfamily. This subfamily also includes the putative P-type H(+)-ATPase, MJ1226p of the anaerobic hyperthermophilic archaea Methanococcus jannaschii. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319771 [Multi-domain]  Cd Length: 781  Bit Score: 245.99  E-value: 3.11e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   67 GLATD-LDKRKEVFGRNLIPPKKP---KTFLQLVWEALQdvtlIILEIAALISLGLsfyqppgegntdacgdakagaede 142
Cdd:cd02076     1 GLTSEeAAKRLKEYGPNELPEKKEnpiLKFLSFFWGPIP----WMLEAAAILAAAL------------------------ 52
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  143 geseAGWIEGAAILLSVVCVvlvtAFNDWSKEKQFRGLQSRIEQ--EQKFQVVRGGQVIQLPVADILVGDIAQIKYGDLL 220
Cdd:cd02076    53 ----GDWVDFAIILLLLLIN----AGIGFIEERQAGNAVAALKKslAPKARVLRDGQWQEIDAKELVPGDIVSLKIGDIV 124
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  221 PADGVLIQGNDLKIDESSLTGESdhvrKAADKDP--MLLSGTHVMEGSGRMVVTAVGVNSQSGiiftllgaggeeeekke 298
Cdd:cd02076   125 PADARLLTGDALQVDQSALTGES----LPVTKHPgdEAYSGSIVKQGEMLAVVTATGSNTFFG----------------- 183
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  299 kkgqaledghplpdcshpsshpiatiatdgaasaNTPAntsLVNgkmqdgnmennqtkvkkqdgaaamemqplksaegge 378
Cdd:cd02076   184 ----------------------------------KTAA---LVA------------------------------------ 190
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  379 teekekkktsvskkeKSVLQGKLTKLAVQIGKAGLVMSAITVIILVLYfaidTFVRQKrpwltecTPIYIQYFVkffiig 458
Cdd:cd02076   191 ---------------SAEEQGHLQKVLNKIGNFLILLALILVLIIVIV----ALYRHD-------PFLEILQFV------ 238
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  459 VTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTavqvyvadvhyktIPEP 538
Cdd:cd02076   239 LVLLIASIPVAMPAVLTVTMAVGALELAKKKAIVSRLSAIEELAGVDILCSDKTGTLTLNKLS-------------LDEP 305
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  539 TSLPSKTLDILVnaisLNSAYTTKILPADkegglpkqVGNKTecgflglVLDVKRDYQTIRNQIPEEKLYKvytFNSVRK 618
Cdd:cd02076   306 YSLEGDGKDELL----LLAALASDTENPD--------AIDTA-------ILNALDDYKPDLAGYKQLKFTP---FDPVDK 363
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  619 -SMSTVIKlPDGSFRMYSKGASEIILKKCSRilsevgeprvfrPRDRDEMVKKVIEPMACDGLRTICVGYrdfpKDPEPN 697
Cdd:cd02076   364 rTEATVED-PDGERFKVTKGAPQVILELVGN------------DEAIRQAVEEKIDELASRGYRSLGVAR----KEDGGR 426
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  698 WEdenniltdltaicVVGI---EDPVRPEVPDAIQKCQRAGITVRMVTGDNINTARAIAIKCGI---IHPGEDFLCIDGK 771
Cdd:cd02076   427 WE-------------LLGLlplFDPPRPDSKATIARAKELGVRVKMITGDQLAIAKETARQLGMgtnILSAERLKLGGGG 493
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  772 efnrriRNEKGEVEQERIDKVwpklRVLARSSPTDKHTLVKgiidsTLVDQRQVVAVTGDGTNDGPALKKADVGFAMGIA 851
Cdd:cd02076   494 ------GGMPGSELIEFIEDA----DGFAEVFPEHKYRIVE-----ALQQRGHLVGMTGDGVNDAPALKKADVGIAVSGA 558
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  852 gTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVnVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTF 931
Cdd:cd02076   559 -TDAARAAADIVLTAPGLSVIIDAIKTSRQIFQRMKSYVIYRIAE-TLRILVFFTLGILILNFYPLPLIMIVLIAILNDG 636

                  ....*..
gi 181339464  932 ASLALAT 938
Cdd:cd02076   637 ATLTIAY 643
P-type_ATPase_Mg cd02077
magnesium transporting ATPase (MgtA), similar to Escherichia coli MgtA and Salmonella ...
67-950 1.66e-64

magnesium transporting ATPase (MgtA), similar to Escherichia coli MgtA and Salmonella typhimurium MgtA; MgtA is a membrane protein which actively transports Mg(2+) into the cytosol with its electro-chemical gradient rather than against the gradient as other cation transporters do. It may act both as a transporter and as a sensor for Mg(2+). In Salmonella typhimurium and Escherichia coli, the two-component system PhoQ/PhoP regulates the transcription of the mgtA gene by sensing Mg(2+) concentrations in the periplasm. MgtA is activated by cardiolipin and it highly sensitive to free magnesium in vitro. It consists of a transmembrane domain and three cytosolic domains: nucleotide-binding domain, phosphorylation domain and actuator domain, and belongs to the P-type ATPase type III subfamily. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319772 [Multi-domain]  Cd Length: 768  Bit Score: 234.83  E-value: 1.66e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   67 GL-ATDLDKRKEVFGRNLIPPKKPKTFLQLVWEALQDVTLIILEIAALISLGLSFYQPPGEGNtdacgdakagaedeges 145
Cdd:cd02077     1 GLtNEEAEERLEKYGPNEISHEKFPSWFKLLLKAFINPFNIVLLVLALVSFFTDVLLAPGEFD----------------- 63
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  146 eagwIEGAAILLSVVCVVLVTAF-NDWSKEKQFRGLQSRIEQEQKfqVVRGGQVIQ-LPVADILVGDIAQIKYGDLLPAD 223
Cdd:cd02077    64 ----LVGALIILLMVLISGLLDFiQEIRSLKAAEKLKKMVKNTAT--VIRDGSKYMeIPIDELVPGDIVYLSAGDMIPAD 137
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  224 GVLIQGNDLKIDESSLTGESDHVRKAA-----------DKDPMLLSGTHVMEGSGRMVVTAVGVNSQSGiiftllgagge 292
Cdd:cd02077   138 VRIIQSKDLFVSQSSLTGESEPVEKHAtakktkdesilELENICFMGTNVVSGSALAVVIATGNDTYFG----------- 206
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  293 eeekkekkgqaledghplpdcshpsshpiaTIAtdgaasantpantSLVNGKMQDGNMENNQTKVKKqdgaaamemqplk 372
Cdd:cd02077   207 ------------------------------SIA-------------KSITEKRPETSFDKGINKVSK------------- 230
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  373 saeggeteekekkktsvskkeksvlqgkltklavqigkagLVMSAITVIILVLyFAIDTFvrQKRPWLtectpiyiqyfv 452
Cdd:cd02077   231 ----------------------------------------LLIRFMLVMVPVV-FLINGL--TKGDWL------------ 255
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  453 KFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTAVQVYvaDVHY 532
Cdd:cd02077   256 EALLFALAVAVGLTPEMLPMIVTSNLAKGAVRMSKRKVIVKNLNAIQNFGAMDILCTDKTGTLTQDKIVLERHL--DVNG 333
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  533 KTIPEptslpsktldiLVNAISLNSAYTTKIL-PADKegGLPKQVGNKTECGflglvldVKRDYQTIrNQIPeeklykvy 611
Cdd:cd02077   334 KESER-----------VLRLAYLNSYFQTGLKnLLDK--AIIDHAEEANANG-------LIQDYTKI-DEIP-------- 384
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  612 tFNSVRKSMSTVIKLPDGSFRMYSKGASEIILKKCSRIlsEVGEPRVFRPRDRDEMVKKVIEPMACDGLRTICVGYRDFP 691
Cdd:cd02077   385 -FDFERRRMSVVVKDNDGKHLLITKGAVEEILNVCTHV--EVNGEVVPLTDTLREKILAQVEELNREGLRVLAIAYKKLP 461
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  692 -KDPEPNWEDEnnilTDLTAICVVGIEDPVRPEVPDAIQKCQRAGITVRMVTGDNINTARAIAIKCGIihPGEDflCIDG 770
Cdd:cd02077   462 aPEGEYSVKDE----KELILIGFLAFLDPPKESAAQAIKALKKNGVNVKILTGDNEIVTKAICKQVGL--DINR--VLTG 533
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  771 KEFNRRIRNEKGEVEQERidkvwpklRVLARSSPTDKHTLVkgiidSTLVDQRQVVAVTGDGTNDGPALKKADVGFAMGI 850
Cdd:cd02077   534 SEIEALSDEELAKIVEET--------NIFAKLSPLQKARII-----QALKKNGHVVGFMGDGINDAPALRQADVGISVDS 600
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  851 AgTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVN---VVAVIVAftgACITQDSPLKAVQMLWVNLI 927
Cdd:cd02077   601 A-VDIAKEAADIILLEKDLMVLEEGVIEGRKTFGNILKYIKMTASSNfgnVFSVLVA---SAFLPFLPMLPIQLLLQNLL 676
                         890       900
                  ....*....|....*....|...
gi 181339464  928 MDtFASLALATEPPTESLLmRKP 950
Cdd:cd02077   677 YD-FSQLAIPFDNVDEEFL-KKP 697
P-type_ATPase cd02609
uncharacterized subfamily of P-type ATPase transporter, similar to uncharacterized ...
189-945 2.36e-58

uncharacterized subfamily of P-type ATPase transporter, similar to uncharacterized Streptococcus pneumoniae exported protein 7, Exp7; This subfamily contains P-type ATPase transporters of unknown function, similar to Streptococcus pneumoniae Exp7. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd(2+), and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.


Pssm-ID: 319795 [Multi-domain]  Cd Length: 661  Bit Score: 214.07  E-value: 2.36e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  189 KFQVVRGGQVIQLPVADILVGDIAQIKYGDLLPADGVLIQGNDLKIDESSLTGESDHVRKAADKDpmLLSGTHVMEGSGR 268
Cdd:cd02609    93 KVTVIRDGQEVKIPPEELVLDDILILKPGEQIPADGEVVEGGGLEVDESLLTGESDLIPKKAGDK--LLSGSFVVSGAAY 170
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  269 MVVTAVGVNSQsgiiftllgaggeeeekkekkgqaledghplpdcshpsshpIATIAtdgaasantpantslvngkmqdg 348
Cdd:cd02609   171 ARVTAVGAESY-----------------------------------------AAKLT----------------------- 186
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  349 nmenNQTKVKKqdgaaamemqplksaeggeteekekkktsvskKEKSVLQGKLTKLAVqigkaglVMSAITVIILVLYFa 428
Cdd:cd02609   187 ----LEAKKHK--------------------------------LINSELLNSINKILK-------FTSFIIIPLGLLLF- 222
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  429 IDTFVRQKRPWLTEctpiyiqyfvkffIIG-VTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAI 507
Cdd:cd02609   223 VEALFRRGGGWRQA-------------VVStVAALLGMIPEGLVLLTSVALAVGAIRLAKKKVLVQELYSIETLARVDVL 289
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  508 CSDKTGTLTTNRMTAVQVYVADVHYKTIPEptslpsKTLDILVNAISLNSAyTTKILPADKEGGLPKQVgnktecgflgl 587
Cdd:cd02609   290 CLDKTGTITEGKMKVERVEPLDEANEAEAA------AALAAFVAASEDNNA-TMQAIRAAFFGNNRFEV----------- 351
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  588 vldvkrdyqtiRNQIPeeklykvytFNSVRKsMSTVIKLPDGSFRMyskGASEIILkkcsrilsevgeprvfrpRDRDEM 667
Cdd:cd02609   352 -----------TSIIP---------FSSARK-WSAVEFRDGGTWVL---GAPEVLL------------------GDLPSE 389
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  668 VKKVIEPMACDGLRTICVGYRDFPKDPEPnwedennILTDLTAICVVGIEDPVRPEVPDAIQKCQRAGITVRMVTGDNIN 747
Cdd:cd02609   390 VLSRVNELAAQGYRVLLLARSAGALTHEQ-------LPVGLEPLALILLTDPIRPEAKETLAYFAEQGVAVKVISGDNPV 462
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  748 TARAIAIKCGIihPGEDfLCIDGkefnrriRNEKGEVEqerIDKVWPKLRVLARSSPTDKHTLVKgiidsTLVDQRQVVA 827
Cdd:cd02609   463 TVSAIAKRAGL--EGAE-SYIDA-------STLTTDEE---LAEAVENYTVFGRVTPEQKRQLVQ-----ALQALGHTVA 524
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  828 VTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTG 907
Cdd:cd02609   525 MTGDGVNDVLALKEADCSIAMA-SGSDATRQVAQVVLLDSDFSALPDVVFEGRRVVNNIERVASLFLVKTIYSVLLALIC 603
                         730       740       750
                  ....*....|....*....|....*....|....*...
gi 181339464  908 ACITQDSPLKAVQMLWVNLIMDTFASLALATEPPTESL 945
Cdd:cd02609   604 VITALPFPFLPIQITLISLFTIGIPSFFLALEPNKRRI 641
ZntA COG2217
Cation-transporting P-type ATPase [Inorganic ion transport and metabolism];
192-907 2.38e-48

Cation-transporting P-type ATPase [Inorganic ion transport and metabolism];


Pssm-ID: 441819 [Multi-domain]  Cd Length: 717  Bit Score: 184.96  E-value: 2.38e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  192 VVRGGQVIQLPVADILVGDIAQIKYGDLLPADGVLIQGNDLkIDESSLTGESDHVRKAADkDPmLLSGTHVMEGSGRMVV 271
Cdd:COG2217   217 VLRDGEEVEVPVEELRVGDRVLVRPGERIPVDGVVLEGESS-VDESMLTGESLPVEKTPG-DE-VFAGTINLDGSLRVRV 293
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  272 TAVGVNSQ-SGIIftllgaggeeeekkekkgQALEDghplpdcSHPSSHPIATIAtDGAASANTPAntslvngkmqdgnm 350
Cdd:COG2217   294 TKVGSDTTlARII------------------RLVEE-------AQSSKAPIQRLA-DRIARYFVPA-------------- 333
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  351 ennqtkvkkqdgaaamemqplksaeggeteekekkktsvskkeksVLqgkltklavqigkaglvmsAITVIILVLyfaid 430
Cdd:COG2217   334 ---------------------------------------------VL-------------------AIAALTFLV----- 344
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  431 tfvrqkrpWLtectpIYIQYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSD 510
Cdd:COG2217   345 --------WL-----LFGGDFSTALYRAVAVLVIACPCALGLATPTAIMVGTGRAARRGILIKGGEALERLAKVDTVVFD 411
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  511 KTGTLTTNRMTAVQVYVADvhyktipeptslPSKTLDILVNAISLNSAYT----TKILPADKEGGLPkqvgnktecgflg 586
Cdd:COG2217   412 KTGTLTEGKPEVTDVVPLD------------GLDEDELLALAAALEQGSEhplaRAIVAAAKERGLE------------- 466
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  587 lVLDVkRDYQTIrnqipeeklykvytfnsVRKSMSTVIklpDGSfrmyskgaseiilkkcsRILseVGEPRVFRPR--DR 664
Cdd:COG2217   467 -LPEV-EDFEAI-----------------PGKGVEATV---DGK-----------------RVL--VGSPRLLEEEgiDL 505
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  665 DEMVKKVIEPMACDGLRTICVGyrdfpkdpepnWEDEnniltdltAICVVGIEDPVRPEVPDAIQKCQRAGITVRMVTGD 744
Cdd:COG2217   506 PEALEERAEELEAEGKTVVYVA-----------VDGR--------LLGLIALADTLRPEAAEAIAALKALGIRVVMLTGD 566
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  745 NINTARAIAIKCGIIHpgedflcidgkefnrrirnekgeveqeridkvwpklrVLARSSPTDKHTLVKgiidsTLVDQRQ 824
Cdd:COG2217   567 NERTAEAVARELGIDE-------------------------------------VRAEVLPEDKAAAVR-----ELQAQGK 604
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  825 VVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVA 904
Cdd:COG2217   605 KVAMVGDGINDAPALAAADVGIAMG-SGTDVAIEAADIVLMRDDLRGVPDAIRLSRATMRIIRQNLFWAFGYNVIGIPLA 683

                  ...
gi 181339464  905 FTG 907
Cdd:COG2217   684 AGG 686
Cation_ATPase_C pfam00689
Cation transporting ATPase, C-terminus; Members of this families are involved in Na+/K+, H+/K+, ...
914-1092 2.53e-48

Cation transporting ATPase, C-terminus; Members of this families are involved in Na+/K+, H+/K+, Ca++ and Mg++ transport. This family represents 5 transmembrane helices.


Pssm-ID: 376368 [Multi-domain]  Cd Length: 175  Bit Score: 169.73  E-value: 2.53e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   914 SPLKAVQMLWVNLIMDTFASLALATEPPTESLLMRKPYGRNKPLISSTMTKNILGHGVYQLVIIFSLLFVGEQIFDIDSG 993
Cdd:pfam00689    2 LPLTPIQILWINLVTDGLPALALGFEPPEPDLMKRPPRKPKEPLFSRKMLRRILLQGLLIAILTLLVFFLGLLGFGISES 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   994 RNAplhsppsehYTIIFNTFVMMQLFNEINARKIHGERNVFdGIFRNPIFCSIVVGTFAIQIVIVQ--FGGKPFSCSPLD 1071
Cdd:pfam00689   82 QNA---------QTMAFNTLVLSQLFNALNARSLRRSLFKI-GLFSNKLLLLAILLSLLLQLLIIYvpPLQAVFGTTPLS 151
                          170       180
                   ....*....|....*....|.
gi 181339464  1072 LEKWMWCVFLGMGELVWGQVI 1092
Cdd:pfam00689  152 LEQWLIVLLLALVVLLVVELR 172
ATPase-IB_hvy TIGR01525
heavy metal translocating P-type ATPase; This model encompasses two equivalog models for the ...
170-907 8.64e-42

heavy metal translocating P-type ATPase; This model encompasses two equivalog models for the copper and cadmium-type heavy metal transporting P-type ATPases (TIGR01511 and TIGR01512) as well as those species which score ambiguously between both models. For more comments and references, see the files on TIGR01511 and 01512.


Pssm-ID: 273669 [Multi-domain]  Cd Length: 558  Bit Score: 162.42  E-value: 8.64e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   170 DWSKEKQFRGLQSRIEQ--EQKFQVVRGGQVIQLPVADILVGDIAQIKYGDLLPADGVLIQGNDLkIDESSLTGESDHVR 247
Cdd:TIGR01525   36 ERAKSRASDALSALLALapSTARVLQGDGSEEEVPVEELQVGDIVIVRPGERIPVDGVVISGESE-VDESALTGESMPVE 114
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   248 KAADKDpmLLSGTHVMEGSGRMVVTAVGVNSQsgiiftllgaggeeeekkekkgqaledghplpdcshpsshpIATIAtd 327
Cdd:TIGR01525  115 KKEGDE--VFAGTINGDGSLTIRVTKLGEDST-----------------------------------------LAQIV-- 149
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   328 gaasantpantslvngKMqdgnMENNQTkvkkqdgaaamemqplksaeggeteekekkktsvskkEKSVLQGKLTKLAVQ 407
Cdd:TIGR01525  150 ----------------EL----VEEAQS-------------------------------------SKAPIQRLADRIASY 172
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   408 IGKAGLVMSAITVIILVLYFAIdtfvrqkrpwltectpiyiqyFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMK 487
Cdd:TIGR01525  173 YVPAVLAIALLTFVVWLALGAL---------------------WREALYRALTVLVVACPCALGLATPVAILVAIGAAAR 231
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   488 DNNLVRHLDACETMGNATAICSDKTGTLTTNRMTAVQVYVADvhyktipeptslPSKTLDILVNAISLNSAYTTKILPAD 567
Cdd:TIGR01525  232 RGILIKGGDALEKLAKVKTVVFDKTGTLTTGKPTVVDIEPLD------------DASEEELLALAAALEQSSSHPLARAI 299
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   568 KEGGLPKQVGNKTEcgflglvldvkrDYQTIrnqiPEEKLYKVYtfnsvrksmstviklpdgsfrmysKGASEIILKKCS 647
Cdd:TIGR01525  300 VRYAKERGLELPPE------------DVEEV----PGKGVEATV------------------------DGGREVRIGNPR 339
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   648 RILSEvgEPRVFRPRDRDEMVKKVIepmaCDGLRTICVGYRDfpkdpepnwedenniltdlTAICVVGIEDPVRPEVPDA 727
Cdd:TIGR01525  340 FLGNR--ELAIEPISASPDLLNEGE----SQGKTVVFVAVDG-------------------ELLGVIALRDQLRPEAKEA 394
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   728 IQKCQRAG-ITVRMVTGDNINTARAIAIKCGIihpgedflcidgkefnrrirnekgevEQEridkvwpklrVLARSSPTD 806
Cdd:TIGR01525  395 IAALKRAGgIKLVMLTGDNRSAAEAVAAELGI--------------------------DDE----------VHAELLPED 438
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   807 KHTLVKgiidsTLVDQRQVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSI 886
Cdd:TIGR01525  439 KLAIVK-----KLQEEGGPVAMVGDGINDAPALAAADVGIAMG-SGSDVAIEAADIVLLNDDLRSLPTAIDLSRKTRRII 512
                          730       740
                   ....*....|....*....|.
gi 181339464   887 SKFLQFQLTVNVVAVIVAFTG 907
Cdd:TIGR01525  513 KQNLAWALGYNLVAIPLAAGG 533
P-type_ATPase_HM cd02079
P-type heavy metal-transporting ATPase; Heavy metal-transporting ATPases (Type IB ATPases) ...
170-907 2.16e-40

P-type heavy metal-transporting ATPase; Heavy metal-transporting ATPases (Type IB ATPases) transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. These ATPases include mammalian copper-transporting ATPases, ATP7A and ATP7B, Bacillus subtilis CadA which transports cadmium, zinc and cobalt out of the cell, Bacillus subtilis ZosA/PfeT which transports copper, and perhaps also zinc and ferrous iron, Archaeoglobus fulgidus CopA and CopB, Staphylococcus aureus plasmid pI258 CadA, a cadmium-efflux ATPase, and Escherichia coli ZntA which is selective for Pb(2+), Zn(2+), and Cd(2+). The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This family belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319774 [Multi-domain]  Cd Length: 617  Bit Score: 159.30  E-value: 2.16e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  170 DWSKEKQFRGLQSRIEQEQKF-QVVRGGQVIQLPVADILVGDIAQIKYGDLLPADGVLIQGNDLkIDESSLTGESDHVRK 248
Cdd:cd02079   106 ERARSRARSALKALLSLAPETaTVLEDGSTEEVPVDDLKVGDVVLVKPGERIPVDGVVVSGESS-VDESSLTGESLPVEK 184
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  249 AADkDPmLLSGTHVMEGSGRMVVTAVGVNSQ-SGIIftllgaggeeeekkekkgqaledghplpdcshpsshpiatiatd 327
Cdd:cd02079   185 GAG-DT-VFAGTINLNGPLTIEVTKTGEDTTlAKII-------------------------------------------- 218
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  328 gaasantpantslvngKMqdgnMENNQtkvkkqdgaaamemqplksaeggeteekekkktsvskKEKSVLQGKLTKLAVQ 407
Cdd:cd02079   219 ----------------RL----VEEAQ-------------------------------------SSKPPLQRLADRFARY 241
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  408 IGKAGLVMSAITVIILVLYFAidtfvrqkrPWLTEctpiyiqyfvkfFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMK 487
Cdd:cd02079   242 FTPAVLVLAALVFLFWPLVGG---------PPSLA------------LYRALAVLVVACPCALGLATPTAIVAGIGRAAR 300
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  488 DNNLVRHLDACETMGNATAICSDKTGTLTTNRM--TAVQVYVADVHYKTIPEPTSLPSKTLDILVNAISlnSAYTTKILP 565
Cdd:cd02079   301 KGILIKGGDVLETLAKVDTVAFDKTGTLTEGKPevTEIEPLEGFSEDELLALAAALEQHSEHPLARAIV--EAAEEKGLP 378
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  566 adkegglPKQVGNKTEcgFLGLVLDVKRDYQTIRnqipeeklykvytfnsvrksmstviklpdgsfrmyskgaseiilkk 645
Cdd:cd02079   379 -------PLEVEDVEE--IPGKGISGEVDGREVL---------------------------------------------- 403
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  646 csrilseVGEPRVFRPRDRDEMVKKVIEPmacDGLRTICVGyrdfpkdpepnwedennilTDLTAICVVGIEDPVRPEVP 725
Cdd:cd02079   404 -------IGSLSFAEEEGLVEAADALSDA---GKTSAVYVG-------------------RDGKLVGLFALEDQLRPEAK 454
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  726 DAIQKCQRAGITVRMVTGDNINTARAIAIKCGIihpgedflcidgkefnrrirnekgeveqeridkvwpkLRVLARSSPT 805
Cdd:cd02079   455 EVIAELKSGGIKVVMLTGDNEAAAQAVAKELGI-------------------------------------DEVHAGLLPE 497
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  806 DKHTLVKGiidstLVDQRQVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDS 885
Cdd:cd02079   498 DKLAIVKA-----LQAEGGPVAMVGDGINDAPALAQADVGIAMG-SGTDVAIETADIVLLSNDLSKLPDAIRLARRTRRI 571
                         730       740
                  ....*....|....*....|..
gi 181339464  886 ISKFLQFQLTVNVVAVIVAFTG 907
Cdd:cd02079   572 IKQNLAWALGYNAIALPLAALG 593
P-type_ATPase_APLT_Dnf-like cd02073
Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, ...
167-978 2.69e-40

Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C; Aminophospholipid translocases (APLTs), also known as type 4 P-type ATPases, act as flippases, and translocate specific phospholipids from the exoplasmic leaflet to the cytoplasmic leaflet of biological membranes. Yeast Dnf1 and Dnf2 mediate the transport of phosphatidylethanolamine, phosphatidylserine, and phosphatidylcholine from the outer to the inner leaflet of the plasma membrane. This subfamily includes mammalian flippases such as ATP11C which may selectively transports PS and PE from the outer leaflet of the plasma membrane to the inner leaflet. It also includes Arabidopsis phospholipid flippases including ALA1, and Caenorhabditis elegans flippases, including TAT-1, the latter has been shown to facilitate the inward transport of phosphatidylserine. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319770 [Multi-domain]  Cd Length: 836  Bit Score: 161.57  E-value: 2.69e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  167 AFNDWSKEKQFRGLQSRieqeqKFQVVRGGQVIQLPVADILVGDIAQIKYGDLLPADGVLIQGNDLK----IDESSLTGE 242
Cdd:cd02073    67 GYEDIRRHKSDNEVNNR-----PVQVLRGGKFVKKKWKDIRVGDIVRVKNDEFVPADLLLLSSSEPDglcyVETANLDGE 141
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  243 SDH-VRKAADKDPMLLSGTHVMEGSGRMVVTA--VGVNSQSGIIFtllgaggeeeekkekkgqaLEDGHPLPdcshpssh 319
Cdd:cd02073   142 TNLkIRQALPETALLLSEEDLARFSGEIECEQpnNDLYTFNGTLE-------------------LNGGRELP-------- 194
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  320 piatIATD-----GAASANTPANTSLV--NGkmqdgnMEnnqTKVKKQDGAAamemqPLKSaeggeteekekkktsvSKK 392
Cdd:cd02073   195 ----LSPDnlllrGCTLRNTEWVYGVVvyTG------HE---TKLMLNSGGT-----PLKR----------------SSI 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  393 EKsvlqgkltKLAVQIgkaglVMSAITVIILVLYFAIDTFVRQKR-----PWLTECTPI--YIQYFVKF--FIIgvtVLV 463
Cdd:cd02073   241 EK--------KMNRFI-----IAIFCILIVMCLISAIGKGIWLSKhgrdlWYLLPKEERspALEFFFDFltFII---LYN 304
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  464 VAVPegLPLAVTISLAYSV--------KKMMKDNN----LVRHLDACETMGNATAICSDKTGTLTTNRMTAVQVYVADVH 531
Cdd:cd02073   305 NLIP--ISLYVTIEVVKFLqsffinwdLDMYDEETdtpaEARTSNLNEELGQVEYIFSDKTGTLTENIMEFKKCSINGVD 382
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  532 YK----------TIPEPTSLPSKtldILVNAISlnsayttkilPaDkEGGLPKQVGNktecgfLGLVLDVKRDYQTIRNQ 601
Cdd:cd02073   383 YGfflalalchtVVPEKDDHPGQ---LVYQASS----------P-D-EAALVEAARD------LGFVFLSRTPDTVTINA 441
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  602 IPEEKLYK---VYTFNSVRKSMSTVIKLPDGSFRMYSKGASEIILKKCSRILSEVGEPrvfrprdrdemVKKVIEPMACD 678
Cdd:cd02073   442 LGEEEEYEilhILEFNSDRKRMSVIVRDPDGRILLYCKGADSVIFERLSPSSLELVEK-----------TQEHLEDFASE 510
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  679 GLRTICVGYRDFPKDPEPNWEDE-------------------NNILTDLTAICVVGIEDPVRPEVPDAIQKCQRAGITVR 739
Cdd:cd02073   511 GLRTLCLAYREISEEEYEEWNEKydeastalqnreelldevaEEIEKDLILLGATAIEDKLQDGVPETIEALQRAGIKIW 590
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  740 MVTGDNINTARAIAIKCGIIHPG-EDF-LCIDGKEFNrrirnekgEVEQERIDKVWPKLRVLA------RSSPTDKHTLV 811
Cdd:cd02073   591 VLTGDKQETAINIGYSCRLLSEDmENLaLVIDGKTLT--------YALDPELERLFLELALKCkaviccRVSPLQKALVV 662
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  812 KgiidstLVDQRQ--VVAVTGDGTNDGPALKKADVGfaMGIAGtdvaKE------ASDIILTddNFSSIVKAVM-WGRNV 882
Cdd:cd02073   663 K------LVKKSKkaVTLAIGDGANDVSMIQEAHVG--VGISG----QEgmqaarASDYAIA--QFRFLRRLLLvHGRWS 728
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  883 YDSISKFLQFQLTVNVVAVIV-----AFTGAciTQDSPLKAVQMLWVNLImdtFASLalatePP----------TESLLM 947
Cdd:cd02073   729 YQRLAKLILYFFYKNIAFYLTqfwyqFFNGF--SGQTLYDSWYLTLYNVL---FTSL-----PPlvigifdqdvSAETLL 798
                         890       900       910
                  ....*....|....*....|....*....|....*...
gi 181339464  948 RKP--YgrnKPLISSTM--TKNILG---HGVYQLVIIF 978
Cdd:cd02073   799 RYPelY---KPGQLNELfnWKVFLYwilDGIYQSLIIF 833
PRK10517 PRK10517
magnesium-transporting P-type ATPase MgtA;
199-904 2.45e-39

magnesium-transporting P-type ATPase MgtA;


Pssm-ID: 236705 [Multi-domain]  Cd Length: 902  Bit Score: 158.69  E-value: 2.45e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  199 IQLPVADILVGDIAQIKYGDLLPADGVLIQGNDLKIDESSLTGESDHVRKAA-----------DKDPMLLSGTHVMEGSG 267
Cdd:PRK10517  176 LEIPIDQLVPGDIIKLAAGDMIPADLRILQARDLFVAQASLTGESLPVEKFAttrqpehsnplECDTLCFMGTNVVSGTA 255
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  268 RMVVTAVGVNSQSGIIftllgaggeeeekkekkgqaledghplpdcshpsSHPIatIATDGAASAntpantslvngkMQD 347
Cdd:PRK10517  256 QAVVIATGANTWFGQL----------------------------------AGRV--SEQDSEPNA------------FQQ 287
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  348 GnmennqtkvkkqdgaaamemqplksaeggeteekekkktsVSKKekSVLqgkLTKLAvqigkagLVMSAItviilVLYf 427
Cdd:PRK10517  288 G----------------------------------------ISRV--SWL---LIRFM-------LVMAPV-----VLL- 309
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  428 aIDTFVrqKRPWlTECtpiyiqyfvkfFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAI 507
Cdd:PRK10517  310 -INGYT--KGDW-WEA-----------ALFALSVAVGLTPEMLPMIVTSTLARGAVKLSKQKVIVKRLDAIQNFGAMDIL 374
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  508 CSDKTGTLTTNRMtavqvyVADVHYKTIPEPTSlpsktlDILVNAIsLNSAYTT--KILpadkeggLPKQVgnkTECGFL 585
Cdd:PRK10517  375 CTDKTGTLTQDKI------VLENHTDISGKTSE------RVLHSAW-LNSHYQTglKNL-------LDTAV---LEGVDE 431
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  586 GLVLDVKRDYQTIrNQIPeeklykvytFNSVRKSMSTVIKLPDGSFRMYSKGASEIILKKCSRIlsEVGEPRVFRPRDRD 665
Cdd:PRK10517  432 ESARSLASRWQKI-DEIP---------FDFERRRMSVVVAENTEHHQLICKGALEEILNVCSQV--RHNGEIVPLDDIML 499
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  666 EMVKKVIEPMACDGLRTICVGYRDFPKDPEpNWE--DENniltDLTAICVVGIEDPVRPEVPDAIQKCQRAGITVRMVTG 743
Cdd:PRK10517  500 RRIKRVTDTLNRQGLRVVAVATKYLPAREG-DYQraDES----DLILEGYIAFLDPPKETTAPALKALKASGVTVKILTG 574
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  744 DNINTARAIAIKCGIIHP----GEDFLCIDGKEFNRRIRNEkgeveqeridkvwpklRVLARSSPTDKHTLVKgiidsTL 819
Cdd:PRK10517  575 DSELVAAKVCHEVGLDAGevliGSDIETLSDDELANLAERT----------------TLFARLTPMHKERIVT-----LL 633
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  820 VDQRQVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLqfQLTV--- 896
Cdd:PRK10517  634 KREGHVVGFMGDGINDAPALRAADIGISVD-GAVDIAREAADIILLEKSLMVLEEGVIEGRRTFANMLKYI--KMTAssn 710
                         730
                  ....*....|
gi 181339464  897 --NVVAVIVA 904
Cdd:PRK10517  711 fgNVFSVLVA 720
P-type_ATPase_Cu-like cd02094
P-type heavy metal-transporting ATPase, similar to human copper-transporting ATPases, ATP7A ...
192-876 2.85e-39

P-type heavy metal-transporting ATPase, similar to human copper-transporting ATPases, ATP7A and ATP7B; The mammalian copper-transporting P-type ATPases, ATP7A and ATP7B are key molecules required for the regulation and maintenance of copper homeostasis. Menkes and Wilson diseases are caused by mutation in ATP7A and ATP7B respectively. This subfamily includes other copper-transporting ATPases such as: Bacillus subtilis CopA , Archeaoglobus fulgidus CopA, and Saccharomyces cerevisiae Ccc2p. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319783 [Multi-domain]  Cd Length: 647  Bit Score: 156.48  E-value: 2.85e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  192 VVRGGQVIQLPVADILVGDIAQIKYGDLLPADGVLIQGNDLkIDESSLTGESDHVRKAADkDPmLLSGTHVMEGSGRMVV 271
Cdd:cd02094   143 VIRDGKEVEVPIEEVQVGDIVRVRPGEKIPVDGVVVEGESS-VDESMLTGESLPVEKKPG-DK-VIGGTINGNGSLLVRA 219
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  272 TAVGVNSQ-SGIIftllgaggeeeekkekkgqaledghplpdcshpsshpiatiatdgaasantpantslvngKMqdgnM 350
Cdd:cd02094   220 TRVGADTTlAQII------------------------------------------------------------RL----V 235
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  351 ENNQTkvkkqdgaaamemqplksaeggeteekekkktsvSKkeksvlqGKLTKLAVQIgkaglvmSAITV-IILVLyfAI 429
Cdd:cd02094   236 EEAQG----------------------------------SK-------APIQRLADRV-------SGVFVpVVIAI--AI 265
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  430 DTFVR----QKRPWLTECtpiyiqyfvkfFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNAT 505
Cdd:cd02094   266 LTFLVwlllGPEPALTFA-----------LVAAVAVLVIACPCALGLATPTAIMVGTGRAAELGILIKGGEALERAHKVD 334
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  506 AICSDKTGTLTTNRMTavqvyVADVHyktiPEPTSLPSKTLDiLVNAISLNSayttkilpadkEGGLPKQVgnKTECGFL 585
Cdd:cd02094   335 TVVFDKTGTLTEGKPE-----VTDVV----PLPGDDEDELLR-LAASLEQGS-----------EHPLAKAI--VAAAKEK 391
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  586 GLVLDVKRDYQTIrnqipeeklykvytfnsVRKSMSTVIklpDGsfRMYSKGASEIILKKCSRILSEVGEprvfrprdrd 665
Cdd:cd02094   392 GLELPEVEDFEAI-----------------PGKGVRGTV---DG--RRVLVGNRRLMEENGIDLSALEAE---------- 439
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  666 emvkkvIEPMACDGLRTICVGYrdfpkDPEPnwedenniltdltaICVVGIEDPVRPEVPDAIQKCQRAGITVRMVTGDN 745
Cdd:cd02094   440 ------ALALEEEGKTVVLVAV-----DGEL--------------AGLIAVADPLKPDAAEAIEALKKMGIKVVMLTGDN 494
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  746 INTARAIAIKCGIihpgedflcidgkefnrrirnekgeveqeriDKVWpklrvlARSSPTDKHTLVKgiidsTLVDQRQV 825
Cdd:cd02094   495 RRTARAIAKELGI-------------------------------DEVI------AEVLPEDKAEKVK-----KLQAQGKK 532
                         650       660       670       680       690
                  ....*....|....*....|....*....|....*....|....*....|.
gi 181339464  826 VAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTDDNFSSIVKAV 876
Cdd:cd02094   533 VAMVGDGINDAPALAQADVGIAIG-SGTDVAIESADIVLMRGDLRGVVTAI 582
ATPase-IB1_Cu TIGR01511
copper-(or silver)-translocating P-type ATPase; This model describes the P-type ATPase ...
192-904 4.15e-35

copper-(or silver)-translocating P-type ATPase; This model describes the P-type ATPase primarily responsible for translocating copper ions accross biological membranes. These transporters are found in prokaryotes and eukaryotes. This model encompasses those species which pump copper ions out of cells or organelles (efflux pumps such as CopA of Escherichia coli) as well as those which pump the ion into cells or organelles either for the purpose of supporting life in extremely low-copper environments (for example CopA of Enterococcus hirae) or for the specific delivery of copper to a biological complex for which it is a necessary component (for example FixI of Bradyrhizobium japonicum, or CtaA and PacS of Synechocystis). The substrate specificity of these transporters may, to a varying degree, include silver ions (for example, CopA from Archaeoglobus fulgidus). Copper transporters from this family are well known as the genes which are mutated in two human disorders of copper metabolism, Wilson's and Menkes' diseases. The sequences contributing to the seed of this model are all experimentally characterized. The copper P-type ATPases have been characterized as Type IB based on a phylogenetic analysis which combines the copper-translocating ATPases with the cadmium-translocating species. This model and that describing the cadmium-ATPases (TIGR01512) are well separated, and thus we further type the copper-ATPases as IB1 (and the cadmium-ATPases as IB2). Several sequences which have not been characterized experimentally fall just below the cutoffs for both of these models (SP|Q9CCL1 from Mycobacterium leprae, GP|13816263 from Sulfolobus solfataricus, OMNI|NTL01CJ01098 from Campylobacter jejuni, OMNI|NTL01HS01687 from Halobacterium sp., GP|6899169 from Ureaplasma urealyticum and OMNI|HP1503 from Helicobacter pylori). Accession PIR|A29576 from Enterococcus faecalis scores very high against this model, but yet is annotated as an "H+/K+ exchanging ATPase". BLAST of this sequence does not hit anything else annotated in this way. This error may come from the characterization paper published in 1987. Accession GP|7415611 from Saccharomyces cerevisiae appears to be mis-annotated as a cadmium resistance protein. Accession OMNI|NTL01HS00542 from Halobacterium which scores above trusted for this model is annotated as "molybdenum-binding protein" although no evidence can be found for this classification. [Cellular processes, Detoxification, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273664 [Multi-domain]  Cd Length: 562  Bit Score: 142.41  E-value: 4.15e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   192 VVRGGQVIQLPVADILVGDIAQIKYGDLLPADGVLIQGNDlKIDESSLTGESDHVRKAADkDPmLLSGTHVMEGSGRMVV 271
Cdd:TIGR01511   96 LTKDGSIEEVPVALLQPGDIVKVLPGEKIPVDGTVIEGES-EVDESLVTGESLPVPKKVG-DP-VIAGTVNGTGSLVVRA 172
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   272 TAVGVNSQsgiiftllgaggeeeekkekkgqaledghplpdcshpsshpIATIatdgaasantpantslvngkmqdgnme 351
Cdd:TIGR01511  173 TATGEDTT-----------------------------------------LAQI--------------------------- 184
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   352 nnqtkvkkqdgaaaMEMqplksaeggeteekekkktsvskkeksVLQGKLTKLAVQiGKAGLVMSAITVIILVLyfAIDT 431
Cdd:TIGR01511  185 --------------VRL---------------------------VRQAQQSKAPIQ-RLADKVAGYFVPVVIAI--ALIT 220
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   432 FVrqkrpwltectpiyIQYFVkfFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDK 511
Cdd:TIGR01511  221 FV--------------IWLFA--LEFAVTVLIIACPCALGLATPTVIAVATGLAAKNGVLIKDGDALERAANIDTVVFDK 284
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   512 TGTLTTNRMTAVQVYVADVHYKTipeptslpskTLDILVNAISLNSAY--TTKILP-ADKEGGLPKQVGN-KTECGflgl 587
Cdd:TIGR01511  285 TGTLTQGKPTVTDVHVFGDRDRT----------ELLALAAALEAGSEHplAKAIVSyAKEKGITLVTVSDfKAIPG---- 350
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   588 vLDVKRDYQTIRNQIPEEKLYKVYTfnsvrksmstvIKLPDGSfrmyskgaseiiLKKCSRILSEVgeprvfrprdrdem 667
Cdd:TIGR01511  351 -IGVEGTVEGTKIQLGNEKLLGENA-----------IKIDGKA------------GQGSTVVLVAV-------------- 392
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   668 vkkviepmacdglrticvgyrdfpkdpepnwEDEnniltdltAICVVGIEDPVRPEVPDAIQKCQRAGITVRMVTGDNIN 747
Cdd:TIGR01511  393 -------------------------------NGE--------LAGVFALEDQLRPEAKEVIQALKRRGIEPVMLTGDNRK 433
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   748 TARAIAIKCGIihpgedflcidgkefnrrirnekgeveqeridkvwpklRVLARSSPTDKHTLVKgiidsTLVDQRQVVA 827
Cdd:TIGR01511  434 TAKAVAKELGI--------------------------------------DVRAEVLPDDKAALIK-----KLQEKGPVVA 470
                          650       660       670       680       690       700       710
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 181339464   828 VTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVA 904
Cdd:TIGR01511  471 MVGDGINDAPALAQADVGIAIG-AGTDVAIEAADVVLLRNDLNDVATAIDLSRKTLRRIKQNLLWAFGYNVIAIPIA 546
ATPase-Plipid TIGR01652
phospholipid-translocating P-type ATPase, flippase; This model describes the P-type ATPase ...
492-978 4.94e-35

phospholipid-translocating P-type ATPase, flippase; This model describes the P-type ATPase responsible for transporting phospholipids from one leaflet of bilayer membranes to the other. These ATPases are found only in eukaryotes.


Pssm-ID: 273734 [Multi-domain]  Cd Length: 1057  Bit Score: 145.60  E-value: 4.94e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   492 VRHLDACETMGNATAICSDKTGTLTTNRMTAVQVYVADVHY-KTIPEPT--------SLPSKTLDILVNAISLNS----- 557
Cdd:TIGR01652  347 VRTSNLNEELGQVEYIFSDKTGTLTQNIMEFKKCSIAGVSYgDGFTEIKdgirerlgSYVENENSMLVESKGFTFvdprl 426
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   558 ---------------------AYTTKILPA---DKEGGLPKQVGNKTECGF------LGLVLdVKRDYQTIRNQIP---E 604
Cdd:TIGR01652  427 vdllktnkpnakrinefflalALCHTVVPEfndDGPEEITYQAASPDEAALvkaardVGFVF-FERTPKSISLLIEmhgE 505
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   605 EKLYK---VYTFNSVRKSMSTVIKLPDGSFRMYSKGASEIILKkcsrILSEVGeprvfrpRDRDEMVKKVIEPMACDGLR 681
Cdd:TIGR01652  506 TKEYEilnVLEFNSDRKRMSVIVRNPDGRIKLLCKGADTVIFK----RLSSGG-------NQVNEETKEHLENYASEGLR 574
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   682 TICVGYRDFPKDPEPNWEDE-------------------NNILTDLTAICVVGIEDPVRPEVPDAIQKCQRAGITVRMVT 742
Cdd:TIGR01652  575 TLCIAYRELSEEEYEEWNEEyneastaltdreekldvvaESIEKDLILLGATAIEDKLQEGVPETIELLRQAGIKIWVLT 654
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   743 GDNINTARAIAIKCGIIHPG-----------------------------EDF----------LCIDGKEFNRRIrneKGE 783
Cdd:TIGR01652  655 GDKVETAINIGYSCRLLSRNmeqivitsdsldatrsveaaikfglegtsEEFnnlgdsgnvaLVIDGKSLGYAL---DEE 731
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   784 VEQERIDKVWPKLRVLA-RSSPTDKHTLVKGIIDSTlvdQRQVVAVtGDGTNDGPALKKADVGfaMGIAGTD--VAKEAS 860
Cdd:TIGR01652  732 LEKEFLQLALKCKAVICcRVSPSQKADVVRLVKKST---GKTTLAI-GDGANDVSMIQEADVG--VGISGKEgmQAVMAS 805
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   861 DIILTddNFSSIVKAVMW-GRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQ---MLWVNLIMDTFASLAL 936
Cdd:TIGR01652  806 DFAIG--QFRFLTKLLLVhGRWSYKRISKMILYFFYKNLIFAIIQFWYSFYNGFSGQTLYEgwyMVLYNVFFTALPVISL 883
                          570       580       590       600
                   ....*....|....*....|....*....|....*....|....*....
gi 181339464   937 AT--EPPTESLLMRKP--YGRNKpLISSTMTKNILGH---GVYQLVIIF 978
Cdd:TIGR01652  884 GVfdQDVSASLSLRYPqlYREGQ-KGQGFSTKTFWGWmldGIYQSLVIF 931
ATPase-IB2_Cd TIGR01512
heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; This model describes the P-type ...
167-907 4.98e-34

heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; This model describes the P-type ATPase primarily responsible for translocating cadmium ions (and other closely-related divalent heavy metals such as cobalt, mercury, lead and zinc) across biological membranes. These transporters are found in prokaryotes and plants. Experimentally characterized members of the seed alignment include: SP|P37617 from E. coli, SP|Q10866 from Mycobacterium tuberculosis and SP|Q59998 from Synechocystis PCC6803. The cadmium P-type ATPases have been characterized as Type IB based on a phylogenetic analysis which combines the copper-translocating ATPases with the cadmium-translocating species. This model and that describing the copper-ATPases (TIGR01511) are well separated, and thus we further type the copper-ATPases as IB1 and the cadmium-ATPases as IB2. Several sequences which have not been characterized experimentally fall just below trusted cutoff for both of these models (SP|Q9CCL1 from Mycobacterium leprae, GP|13816263 from Sulfolobus solfataricus, OMNI|NTL01CJ01098 from Campylobacter jejuni, OMNI|NTL01HS01687 from Halobacterium sp., GP|6899169 from Ureaplasma urealyticum and OMNI|HP1503 from Helicobacter pylori). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273665 [Multi-domain]  Cd Length: 550  Bit Score: 139.00  E-value: 4.98e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   167 AFNDWSKEKQFRGLQSRIEQE-QKFQVVRGGQVIQLPVADILVGDIAQIKYGDLLPADGVLIQGNDLkIDESSLTGESDH 245
Cdd:TIGR01512   33 TLEEYASGRARRALKALMELApDTARRLQGDSLEEVAVEELKVGDVVVVKPGERVPVDGEVLSGTSS-VDESALTGESVP 111
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   246 VRKAADKDpmLLSGTHVMEGSGRMVVTAVGVNSQsgiiftllgaggeeeekkekkgqaledghplpdcshpsshpIATIA 325
Cdd:TIGR01512  112 VEKAPGDE--VFAGAINLDGVLTIEVTKLPADST-----------------------------------------IAKIV 148
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   326 tdgaasantpantSLVngkmqdgnmENNQtkvkkqdgaaamemqplksaeggeteekekkktsvskKEKSVLQGKLTKLA 405
Cdd:TIGR01512  149 -------------NLV---------EEAQ-------------------------------------SRKAPTQRFIDRFA 169
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   406 VQIgkaglvmsAITVIILVLYFAIDTFVRQKRPWLtectpiyiqyfvKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKM 485
Cdd:TIGR01512  170 RYY--------TPAVLAIALAAALVPPLLGAGPFL------------EWIYRALVLLVVASPCALVISAPAAYLSAISAA 229
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   486 MKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTAVQVYVADVHYKTipeptslpsktlDILVNAISLNSAYT----T 561
Cdd:TIGR01512  230 ARHGILIKGGAALEALAKIKTVAFDKTGTLTTGKPKVTDVHPADGHSES------------EVLRLAAAAEQGSThplaR 297
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   562 KILPADKEGGLPKQVGNKTEcgflglvldvkrdyqtirnqIPEEKLYKVYtfnsvrksmstviklpDGsfrmyskgasei 641
Cdd:TIGR01512  298 AIVDYARARELAPPVEDVEE--------------------VPGEGVRAVV----------------DG------------ 329
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   642 ilkkcsrilsevGEPRVFRPRDRDEMVKKVIEPMaCDGLRTICVGYRDFpkdpepnwedenniltdlTAICVVGIEDPVR 721
Cdd:TIGR01512  330 ------------GEVRIGNPRSLSEAVGASIAVP-ESAGKTIVLVARDG------------------TLLGYIALSDELR 378
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   722 PEVPDAIQKCQRAGI-TVRMVTGDNINTARAIAIKCGIihpgedflcidgkefnrrirnekgeveqeriDKVWPKLRvla 800
Cdd:TIGR01512  379 PDAAEAIAELKALGIkRLVMLTGDRRAVAEAVARELGI-------------------------------DEVHAELL--- 424
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   801 rssPTDKHTLVKgiidsTLVDQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGR 880
Cdd:TIGR01512  425 ---PEDKLEIVK-----ELREKAGPVAMVGDGINDAPALAAADVGIAMGASGSDVALETADVVLLNDDLSRLPQAIRLAR 496
                          730       740
                   ....*....|....*....|....*..
gi 181339464   881 NVYDSISKFLQFQLTVNVVAVIVAFTG 907
Cdd:TIGR01512  497 RTRRIIKQNVVIALGIILVLILLALFG 523
P-ATPase-V TIGR01657
P-type ATPase of unknown pump specificity (type V); These P-type ATPases form a distinct clade ...
461-1022 4.97e-33

P-type ATPase of unknown pump specificity (type V); These P-type ATPases form a distinct clade but the substrate of their pumping activity has yet to be determined. This clade has been designated type V in.


Pssm-ID: 273738 [Multi-domain]  Cd Length: 1054  Bit Score: 139.04  E-value: 4.97e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   461 VLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTAVQVYVADVHYKTIPEPTS 540
Cdd:TIGR01657  405 IITIVVPPALPAELSIGINNSLARLKKKGIFCTSPFRINFAGKIDVCCFDKTGTLTEDGLDLRGVQGLSGNQEFLKIVTE 484
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   541 LPSKTLDILVNAISLNSAyTTKIlpadkEGGLpkqVGN---KTECGFLGLVLDVKRD----YQTIRNQIPEEK-----LY 608
Cdd:TIGR01657  485 DSSLKPSITHKALATCHS-LTKL-----EGKL---VGDpldKKMFEATGWTLEEDDEsaepTSILAVVRTDDPpqelsII 555
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   609 KVYTFNSVRKSMSTVIKLPDGSFRM-YSKGASEIILKKCSRilSEVgeprvfrPRDRDEMVKKVIEpmacDGLRTICVGY 687
Cdd:TIGR01657  556 RRFQFSSALQRMSVIVSTNDERSPDaFVKGAPETIQSLCSP--ETV-------PSDYQEVLKSYTR----EGYRVLALAY 622
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   688 RDFPKdpePNWE-----DENNILTDLTAICVVGIEDPVRPEVPDAIQKCQRAGITVRMVTGDNINTARAIAIKCGII--- 759
Cdd:TIGR01657  623 KELPK---LTLQkaqdlSRDAVESNLTFLGFIVFENPLKPDTKEVIKELKRASIRTVMITGDNPLTAVHVARECGIVnps 699
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   760 ---------------------HPGEDF---------------------------LCIDGKEFNRRIRNEKgeveqERIDK 791
Cdd:TIGR01657  700 ntlilaeaeppesgkpnqikfEVIDSIpfastqveipyplgqdsvedllasryhLAMSGKAFAVLQAHSP-----ELLLR 774
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   792 VWPKLRVLARSSPTDKHTLVKgiidsTLVDQRQVVAVTGDGTNDGPALKKADVGFAM-----GIAGTDVAKEAS-----D 861
Cdd:TIGR01657  775 LLSHTTVFARMAPDQKETLVE-----LLQKLDYTVGMCGDGANDCGALKQADVGISLseaeaSVAAPFTSKLASiscvpN 849
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   862 IILTddnfssivkavmwGR-NVYDSISKFlQFQLTVNVVAVIVAFTGACItqDSPLKAVQMLWVNLIMDTFASLALATEP 940
Cdd:TIGR01657  850 VIRE-------------GRcALVTSFQMF-KYMALYSLIQFYSVSILYLI--GSNLGDGQFLTIDLLLIFPVALLMSRNK 913
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   941 PTESLLMRKPYGR--NKPLISSTMTKNILgHGVYQLVIIFSLL----FVGEQIFDIDSgrnaplHSPPSEHYTIIFntfv 1014
Cdd:TIGR01657  914 PLKKLSKERPPSNlfSVYILTSVLIQFVL-HILSQVYLVFELHaqpwYKPENPVDLEK------ENFPNLLNTVLF---- 982

                   ....*...
gi 181339464  1015 MMQLFNEI 1022
Cdd:TIGR01657  983 FVSSFQYL 990
PRK15122 PRK15122
magnesium-transporting ATPase; Provisional
452-936 1.99e-29

magnesium-transporting ATPase; Provisional


Pssm-ID: 237914 [Multi-domain]  Cd Length: 903  Bit Score: 127.06  E-value: 1.99e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  452 VKFFIIGVT----------VLVVAV---PEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTN 518
Cdd:PRK15122  304 VVLLINGFTkgdwleallfALAVAVgltPEMLPMIVSSNLAKGAIAMARRKVVVKRLNAIQNFGAMDVLCTDKTGTLTQD 383
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  519 RMTAVQVYvaDVHYKtipeptslpsKTLDILVNAIsLNSAYttkilpadkegglpkQVGNKTecgflglVLD--VKRDYQ 596
Cdd:PRK15122  384 RIILEHHL--DVSGR----------KDERVLQLAW-LNSFH---------------QSGMKN-------LMDqaVVAFAE 428
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  597 TIRNQIPEEKLYKV--YTFNSVRKSMSTVIKLPDGSFRMYSKGASEIILKKCSRIlSEVGEPRVFRPRDRDEMVKKVIEP 674
Cdd:PRK15122  429 GNPEIVKPAGYRKVdeLPFDFVRRRLSVVVEDAQGQHLLICKGAVEEMLAVATHV-RDGDTVRPLDEARRERLLALAEAY 507
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  675 MAcDGLRTICVGYRDFPKDPEP---NWEDENniltDLTAICVVGIEDPVRPEVPDAIQKCQRAGITVRMVTGDN-INTA- 749
Cdd:PRK15122  508 NA-DGFRVLLVATREIPGGESRaqySTADER----DLVIRGFLTFLDPPKESAAPAIAALRENGVAVKVLTGDNpIVTAk 582
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  750 --RAIAIKCGIIHPGEDFLCIDGKEFNRrirnekgEVEQERidkvwpklrVLARSSPTDKHTLVKgiidsTLVDQRQVVA 827
Cdd:PRK15122  583 icREVGLEPGEPLLGTEIEAMDDAALAR-------EVEERT---------VFAKLTPLQKSRVLK-----ALQANGHTVG 641
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  828 VTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLqfQLTV-----NVVAVI 902
Cdd:PRK15122  642 FLGDGINDAPALRDADVGISVD-SGADIAKESADIILLEKSLMVLEEGVIKGRETFGNIIKYL--NMTAssnfgNVFSVL 718
                         490       500       510
                  ....*....|....*....|....*....|....
gi 181339464  903 VAftGACITQdSPLKAVQMLWVNLIMDtFASLAL 936
Cdd:PRK15122  719 VA--SAFIPF-LPMLAIHLLLQNLMYD-ISQLSL 748
P-type_ATPase_Cu-like cd07552
P-type heavy metal-transporting ATPase, similar to Archaeoglobus fulgidus CopB, a Cu(2+) ...
192-904 5.60e-29

P-type heavy metal-transporting ATPase, similar to Archaeoglobus fulgidus CopB, a Cu(2+)-ATPase; Archaeoglobus fulgidus CopB transports Cu(2+) from the cytoplasm to the exterior of the cell using ATP as energy source, it transports preferentially Cu(2+) over Cu(+), it is activated by Cu(2+) with high affinity and partially by Cu(+) and Ag(+). This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319850 [Multi-domain]  Cd Length: 632  Bit Score: 124.34  E-value: 5.60e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  192 VVRGGQVIQLPVADILVGDIAQIKYGDLLPADGVLIQGNDLkIDESSLTGESdhvrKAADKDP--MLLSGTHVMEGSGRM 269
Cdd:cd07552   135 LVTDGSIEDVPVSELKVGDVVLVRAGEKIPADGTILEGESS-VNESMVTGES----KPVEKKPgdEVIGGSVNGNGTLEV 209
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  270 VVTAVGVNSQSGIIFTLLGAggeeeekkekkgqaledghplpdcshpsshpiatiatdgAASANTpantslvngKMQDgn 349
Cdd:cd07552   210 KVTKTGEDSYLSQVMELVAQ---------------------------------------AQASKS---------RAEN-- 239
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  350 mennqtkvkKQDGAAamemqplksaeggeteekekkktsvskkeksvlqGKLTKLAVQIGkaglvmsAITVIILVLYFAI 429
Cdd:cd07552   240 ---------LADKVA----------------------------------GWLFYIALGVG-------IIAFIIWLILGDL 269
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  430 DTFVrqkrpwltectpiyiqyfvkffIIGVTVLVVAVPEGL----PLAVTISLAYSVKKMMkdnnLVRHLDACETMGNAT 505
Cdd:cd07552   270 AFAL----------------------ERAVTVLVIACPHALglaiPLVVARSTSIAAKNGL----LIRNREALERARDID 323
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  506 AICSDKTGTLTTNRMTAVQVYVADVHYKTipeptslpsktlDIL--VNAISLNSAY--TTKILPADKEGGLP----KQVG 577
Cdd:cd07552   324 VVLFDKTGTLTEGKFGVTDVITFDEYDED------------EILslAAALEAGSEHplAQAIVSAAKEKGIRpvevENFE 391
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  578 NKTECGFLGLVLDvkRDYQTIRnqipeEKLYKvytfnsvrksmstviklpdgsfrmyskgaseiilkkcsRILSEVGEPR 657
Cdd:cd07552   392 NIPGVGVEGTVNG--KRYQVVS-----PKYLK--------------------------------------ELGLKYDEEL 426
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  658 VFRPRDRDEMVKKVIEpmacdglrticvgyrdfpkdpepnwEDEnniltdltAICVVGIEDPVRPEVPDAIQKCQRAGIT 737
Cdd:cd07552   427 VKRLAQQGNTVSFLIQ-------------------------DGE--------VIGAIALGDEIKPESKEAIRALKAQGIT 473
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  738 VRMVTGDNINTARAIAIKCGIIhpgedflcidgkefnrrirnekgeveqeridkvwpklRVLARSSPTDKHTLVKgiids 817
Cdd:cd07552   474 PVMLTGDNEEVAQAVAEELGID-------------------------------------EYFAEVLPEDKAKKVK----- 511
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  818 TLVDQRQVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVN 897
Cdd:cd07552   512 ELQAEGKKVAMVGDGVNDAPALAQADVGIAIG-AGTDVAIESADVVLVKSDPRDIVDFLELAKATYRKMKQNLWWGAGYN 590

                  ....*..
gi 181339464  898 VVAVIVA 904
Cdd:cd07552   591 VIAIPLA 597
P-type_ATPase_cation cd07542
P-type cation-transporting ATPases, similar to human ATPase type 13A2 (ATP13A2) protein and ...
461-983 5.55e-28

P-type cation-transporting ATPases, similar to human ATPase type 13A2 (ATP13A2) protein and Saccharomyces cerevisiae Ypk9p; Saccharomyces cerevisiae Yph9p localizes to the yeast vacuole and may play a role in sequestering heavy metal ions, its deletion confers sensitivity for growth for cadmium, manganese, nickel or selenium. Human ATP13A2 (PARK9/CLN12) is a lysosomal transporter with zinc as the possible substrate. Mutation in the ATP13A2 gene has been linked to Parkinson's disease and Kufor-Rakeb syndrome, and to neuronal ceroid lipofuscinoses. ATP13A3/AFURS1 is a candidate gene for oculo auriculo vertebral spectrum (OAVS), being one of nine genes included in a 3q29 microduplication in a patient with OAVS. Mutation in the human ATP13A4 may be involved in a speech-language disorder. This subfamily also includes zebrafish ATP13A2 a lysosome-specific transmembrane ATPase protein of unknown function which plays a crucial role during embryonic development, its deletion is lethal. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319842 [Multi-domain]  Cd Length: 760  Bit Score: 121.97  E-value: 5.55e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  461 VLVVAVPEGLPLAVTISLAYSVKKmmkdnnLVRHLDAC---ETMGNATAI---CSDKTGTLTTNRMTAVQVYVADVHYKT 534
Cdd:cd07542   262 IITIVVPPALPAALTVGIIYAQSR------LKKKGIFCispQRINICGKInlvCFDKTGTLTEDGLDLWGVRPVSGNNFG 335
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  535 IPEPTSLPSKTLDILVNAISLNSAYTTKILpadkegglpKQVGNKtecgFLGLVLDVKRDYQTirNQIPEekLYKVYTFN 614
Cdd:cd07542   336 DLEVFSLDLDLDSSLPNGPLLRAMATCHSL---------TLIDGE----LVGDPLDLKMFEFT--GWSLE--ILRQFPFS 398
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  615 SVRKSMSTVIKLP-DGSFRMYSKGASEIILKKCSrilsevgePRVFrPRDRDEMVKKviepMACDGLRTICVGYRDFPKd 693
Cdd:cd07542   399 SALQRMSVIVKTPgDDSMMAFTKGAPEMIASLCK--------PETV-PSNFQEVLNE----YTKQGFRVIALAYKALES- 464
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  694 pePNWEDEN----NILTDLTAICVVGIEDPVRPEVPDAIQKCQRAGITVRMVTGDNINTARAIAIKCGIIHPGEDFLCId 769
Cdd:cd07542   465 --KTWLLQKlsreEVESDLEFLGLIVMENRLKPETAPVINELNRANIRTVMVTGDNLLTAISVARECGMISPSKKVILI- 541
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  770 gkEFNRRIRNEKGEVEqeriDKVWPKLRVLARSSPTDKHTLVKGI--IDSTlvdqrqvVAVTGDGTNDGPALKKADVGFA 847
Cdd:cd07542   542 --EAVKPEDDDSASLT----WTLLLKGTVFARMSPDQKSELVEELqkLDYT-------VGMCGDGANDCGALKAADVGIS 608
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  848 MGIAGTDVakeASDIILTDDNFSSIVKAVMWGRNVYD---SISKFLqfqltvnVVAVIVAFTGACI--TQDSPLKAVQML 922
Cdd:cd07542   609 LSEAEASV---AAPFTSKVPDISCVPTVIKEGRAALVtsfSCFKYM-------ALYSLIQFISVLIlySINSNLGDFQFL 678
                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 181339464  923 WVNLIMDTFASLALATEPPTESLLMRKPYGRnkpLISSTMTKNILGHGVYQLVIIFSLLFV 983
Cdd:cd07542   679 FIDLVIITPIAVFMSRTGAYPKLSSKRPPAS---LVSPPVLVSLLGQIVLILLFQVIGFLI 736
ATP_Ca_trans_C pfam12424
Plasma membrane calcium transporter ATPase C terminal; This domain family is found in ...
1137-1183 5.73e-27

Plasma membrane calcium transporter ATPase C terminal; This domain family is found in eukaryotes, and is approximately 60 amino acids in length. The family is found in association with pfam00689, pfam00122, pfam00702, pfam00690. There is a conserved QTQ sequence motif. This family is the C terminal of a calcium transporting ATPase located in the plasma membrane.


Pssm-ID: 463575  Cd Length: 47  Bit Score: 104.02  E-value: 5.73e-27
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 181339464  1137 GQILWFRGLNRIQTQIRVVNAFRSSLYEGLEKPESRTSIHNFMTHPE 1183
Cdd:pfam12424    1 GQILWFRGLNRIQTQIRVVKAFQSSLREGIQKPYLRNSIHSFMSHPE 47
P-type_ATPase_HM cd07550
P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily ...
170-907 1.42e-26

P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily of the heavy metal-transporting ATPases (Type IB ATPases) which transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319848 [Multi-domain]  Cd Length: 592  Bit Score: 116.61  E-value: 1.42e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  170 DWSKEKQFRGL-QSRIEQEQKFQVVRGGQVIQLPVADILVGDIAQIKYGDLLPADGVLIQGNDLkIDESSLTGESDHVRK 248
Cdd:cd07550    81 DYTARKSEKALlDLLSPQERTVWVERDGVEVEVPADEVQPGDTVVVGAGDVIPVDGTVLSGEAL-IDQASLTGESLPVEK 159
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  249 -AADKdpmLLSGTHVMEGSGRMVVTAVGVNSQSGIIFTLLgaggeeeekkekkgqaledghplpdcshpsshpiatiatd 327
Cdd:cd07550   160 rEGDL---VFASTVVEEGQLVIRAERVGRETRAARIAELI---------------------------------------- 196
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  328 gaasantpantslvngkmqdgnmenNQTKVKKQDgaaamemqplksaeggeteekekkktsvskkeksvLQGKLTKLAVQ 407
Cdd:cd07550   197 -------------------------EQSPSLKAR-----------------------------------IQNYAERLADR 216
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  408 IGKAGLVMSAITviilvlYFAIDTFVRqkrpwltectpiyiqyfvkffiiGVTVLVV----AVPEGLPLAVTISLAYSVK 483
Cdd:cd07550   217 LVPPTLGLAGLV------YALTGDISR-----------------------AAAVLLVdfscGIRLSTPVAVLSALNHAAR 267
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  484 KMMkdnnLVRHLDACETMGNATAICSDKTGTLTTNRMTAVQVyvadvhyktIPEPTSLPSKtlDILVNAISLNSAYT--- 560
Cdd:cd07550   268 HGI----LVKGGRALELLAKVDTVVFDKTGTLTEGEPEVTAI---------ITFDGRLSEE--DLLYLAASAEEHFPhpv 332
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  561 -TKILPADKEGGLPKQVGNKTECgFLGLVLDVKRDYQTIRnqipeeklykvytfnsvrksmstViklpdGSFRMYskGAS 639
Cdd:cd07550   333 aRAIVREAEERGIEHPEHEEVEY-IVGHGIASTVDGKRIR-----------------------V-----GSRHFM--EEE 381
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  640 EIILKkcsrilsevgeprvfrprdrdEMVKKVIEPMACDGLRTICVGYrdfpkdpepnwedenniltDLTAICVVGIEDP 719
Cdd:cd07550   382 EIILI---------------------PEVDELIEDLHAEGKSLLYVAI-------------------DGRLIGVIGLSDP 421
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  720 VRPEVPDAIQKCQRAG-ITVRMVTGDNINTARAIAikcgiihpgedflcidgkefnrrirnekgevEQERIDkvwpklRV 798
Cdd:cd07550   422 LRPEAAEVIARLRALGgKRIIMLTGDHEQRARALA-------------------------------EQLGID------RY 464
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  799 LARSSPTDKHTLVKgiidsTLVDQRQVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTDDNFSSIVKAVMW 878
Cdd:cd07550   465 HAEALPEDKAEIVE-----KLQAEGRTVAFVGDGINDSPALSYADVGISMR-GGTDIARETADVVLLEDDLRGLAEAIEL 538
                         730       740
                  ....*....|....*....|....*....
gi 181339464  879 GRNVYDSISKFLQFQLTVNVVAVIVAFTG 907
Cdd:cd07550   539 ARETMALIKRNIALVVGPNTAVLAGGVFG 567
P-type_ATPase_HM_ZosA_PfeT-like cd07551
P-type heavy metal-transporting ATPase, similar to Bacillus subtilis ZosA/PfeT which ...
187-907 1.78e-25

P-type heavy metal-transporting ATPase, similar to Bacillus subtilis ZosA/PfeT which transports copper, and perhaps zinc under oxidative stress, and perhaps ferrous iron; Bacillus subtilis ZosA/PfeT (previously known as YkvW) transports copper, it may also transport zinc under oxidative stress and may also be involved in ferrous iron efflux. ZosA/PfeT is expressed under the regulation of the peroxide-sensing repressor PerR. It is involved in competence development. Disruption of the zosA/pfeT gene results in low transformability. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319849 [Multi-domain]  Cd Length: 611  Bit Score: 113.11  E-value: 1.78e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  187 EQKFQVVRGGQVIQLPVADILVGDIAQIKYGDLLPADGVLIQGNDlKIDESSLTGESDHVRKAADKDpmLLSGTHVMEGS 266
Cdd:cd07551   112 ETARRIQRDGEIEEVPVEELQIGDRVQVRPGERVPADGVILSGSS-SIDEASITGESIPVEKTPGDE--VFAGTINGSGA 188
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  267 GRMVVTAVgvNSQSgiiftllgaggeeeekkekkgqaledghplpdcshpsshPIATIATdgaasantpantsLVngkmq 346
Cdd:cd07551   189 LTVRVTKL--SSDT---------------------------------------VFAKIVQ-------------LV----- 209
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  347 dgnmENNQTkvkkqdgaaamemqplksaeggeteekekkktsvskkEKSVLQGKLTKLavQIGKAGLVMSAITVIILVLY 426
Cdd:cd07551   210 ----EEAQS-------------------------------------EKSPTQSFIERF--ERIYVKGVLLAVLLLLLLPP 246
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  427 FAIDtfvrqkRPWLTEctpiyiqyfvkfFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATA 506
Cdd:cd07551   247 FLLG------WTWADS------------FYRAMVFLVVASPCALVASTPPATLSAIANAARQGVLFKGGVHLENLGSVKA 308
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  507 ICSDKTGTLTTNRMTAVQVYVADvhyktipeptSLPSKTLDILVNAISLNS------AYTTKILPADKEGGLPKQVGNKT 580
Cdd:cd07551   309 IAFDKTGTLTEGKPRVTDVIPAE----------GVDEEELLQVAAAAESQSehplaqAIVRYAEERGIPRLPAIEVEAVT 378
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  581 ECGFLGLVldvkrdyqtirnqipEEKLYKVytfnsvrksmstviklpdgsfrmyskgaseiilkkcsrilsevGEPRVFR 660
Cdd:cd07551   379 GKGVTATV---------------DGQTYRI-------------------------------------------GKPGFFG 400
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  661 PRDRDEMVKKVIEPMACDGLRTICVgyrdfpkdpepnWEDEnniltdlTAICVVGIEDPVRPEVPDAIQKCQRAGITVRM 740
Cdd:cd07551   401 EVGIPSEAAALAAELESEGKTVVYV------------ARDD-------QVVGLIALMDTPRPEAKEAIAALRLGGIKTIM 461
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  741 VTGDNINTARAIAIKCGIihpgedflcidgkefnrrirnekgeveqeriDKVWPKLRvlarssPTDKHTLVKgiidsTLV 820
Cdd:cd07551   462 LTGDNERTAEAVAKELGI-------------------------------DEVVANLL------PEDKVAIIR-----ELQ 499
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  821 DQRQVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVA 900
Cdd:cd07551   500 QEYGTVAMVGDGINDAPALANADVGIAMG-AGTDVALETADVVLMKDDLSKLPYAIRLSRKMRRIIKQNLIFALAVIALL 578

                  ....*..
gi 181339464  901 VIVAFTG 907
Cdd:cd07551   579 IVANLFG 585
E1-E2_ATPase pfam00122
E1-E2 ATPase;
191-487 2.35e-25

E1-E2 ATPase;


Pssm-ID: 425475 [Multi-domain]  Cd Length: 181  Bit Score: 104.19  E-value: 2.35e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   191 QVVRGGQVIQLPVADILVGDIAQIKYGDLLPADGVLIQGNDLkIDESSLTGESDHVRKaaDKDPMLLSGTHVMEGSGRMV 270
Cdd:pfam00122    8 TVLRDGTEEEVPADELVPGDIVLLKPGERVPADGRIVEGSAS-VDESLLTGESLPVEK--KKGDMVYSGTVVVSGSAKAV 84
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   271 VTAVGVNSQSGIIftllgaggeeeekkekkgqaledghplpdcshpsshpiatiatdgaasantpantslvngkmqdgnm 350
Cdd:pfam00122   85 VTATGEDTELGRI------------------------------------------------------------------- 97
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   351 ennqtkvkkqdgAAAMEMqplksaeggeteekekkktsvSKKEKSVLQGKLTKLAVQIGKAGLVMSAITVIILVLYFAID 430
Cdd:pfam00122   98 ------------ARLVEE---------------------AKSKKTPLQRLLDRLGKYFSPVVLLIALAVFLLWLFVGGPP 144
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 181339464   431 TFVrqkrpwltectpiyiqyfvkfFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMK 487
Cdd:pfam00122  145 LRA---------------------LLRALAVLVAACPCALPLATPLALAVGARRLAK 180
P-type_ATPase_Cd-like cd07545
P-type heavy metal-transporting ATPase, similar to Staphylococcus aureus plasmid pI258 CadA, a ...
192-934 2.52e-24

P-type heavy metal-transporting ATPase, similar to Staphylococcus aureus plasmid pI258 CadA, a cadmium-efflux ATPase; CadA from gram-positive Staphylococcus aureus plasmid pI258 is required for full Cd(2+) and Zn(2+) resistance. This subfamily also includes CadA, from the gram-negative bacilli, Stenotrophomonas maltophilia D457R, which is a cadmium efflux pump acquired as part of a cluster of antibiotic and heavy metal resistance genes from gram-positive bacteria. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319845 [Multi-domain]  Cd Length: 599  Bit Score: 109.43  E-value: 2.52e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  192 VVRGGQVIQLPVADILVGDIAQIKYGDLLPADGVLIQGNDLkIDESSLTGESDHVRKAADKDpmLLSGThvMEGSGrmvv 271
Cdd:cd07545   100 VRRDGQEREVPVAEVAVGDRMIVRPGERIAMDGIIVRGESS-VNQAAITGESLPVEKGVGDE--VFAGT--LNGEG---- 170
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  272 tavgvnsqsgiiftllgaggeeeekkekkgqALEdghplpdcshpsshpiatIATDGAASANTPAntslvngKMQDgNME 351
Cdd:cd07545   171 -------------------------------ALE------------------VRVTKPAEDSTIA-------RIIH-LVE 193
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  352 NNQTkvkkqdgaaamemqplksaeggeteekekkktsvskkEKSVLQGKLTKLAVQIGKAGLVMSAITVIILVLYFAIDT 431
Cdd:cd07545   194 EAQA-------------------------------------ERAPTQAFVDRFARYYTPVVMAIAALVAIVPPLFFGGAW 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  432 FvrqkrPWltectpIYIqyfvkffiiGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDK 511
Cdd:cd07545   237 F-----TW------IYR---------GLALLVVACPCALVISTPVSIVSAIGNAARKGVLIKGGVYLEELGRLKTVAFDK 296
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  512 TGTLTTNRMTAVQVYVADvhyktipeptSLPSKTLDILVNAISLNSAY--TTKILPADKEGGLPkqvgnktecgflglvL 589
Cdd:cd07545   297 TGTLTKGKPVVTDVVVLG----------GQTEKELLAIAAALEYRSEHplASAIVKKAEQRGLT---------------L 351
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  590 DVKRDYQTIrnqipeeklykvytfnsVRKSMSTVIklpDGsfRMYskgaseiilkkcsrilsEVGEPRVFrprdrDEMVK 669
Cdd:cd07545   352 SAVEEFTAL-----------------TGRGVRGVV---NG--TTY-----------------YIGSPRLF-----EELNL 387
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  670 KVIEPMACDgLRTIcvgyrdfpkdpepnwEDENN----ILTDLTAICVVGIEDPVRPEVPDAIQKCQRAGI--TVrMVTG 743
Cdd:cd07545   388 SESPALEAK-LDAL---------------QNQGKtvmiLGDGERILGVIAVADQVRPSSRNAIAALHQLGIkqTV-MLTG 450
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  744 DNINTARAIAIKCGIihpgedflcidgkefnrrirnekGEVEQERIdkvwpklrvlarssPTDKHTLVKGiidstLVDQR 823
Cdd:cd07545   451 DNPQTAQAIAAQVGV-----------------------SDIRAELL--------------PQDKLDAIEA-----LQAEG 488
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  824 QVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIV 903
Cdd:cd07545   489 GRVAMVGDGVNDAPALAAADVGIAMGAAGTDTALETADIALMGDDLRKLPFAVRLSRKTLAIIKQNIAFALGIKLIALLL 568
                         730       740       750
                  ....*....|....*....|....*....|.
gi 181339464  904 AFTGacitqdsplkaVQMLWVNLIMDTFASL 934
Cdd:cd07545   569 VIPG-----------WLTLWMAVFADMGASL 588
P-type_ATPase_APLT cd07536
Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, ...
395-978 2.37e-23

Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, Neo1p, and human ATP8A2, -9B, -10D, -11B, and -11C; Aminophospholipid translocases (APLTs), also known as type 4 P-type ATPases, act as flippases, and translocate specific phospholipids from the exoplasmic leaflet to the cytoplasmic leaflet of biological membranes. Yeast Dnf1 and Dnf2 mediate the transport of phosphatidylethanolamine, phosphatidylserine, and phosphatidylcholine from the outer to the inner leaflet of the plasma membrane. Mammalian ATP11C may selectively transports PS and PE from the outer leaflet of the plasma membrane to the inner leaflet. The yeast Neo1p localizes to the endoplasmic reticulum and the Golgi complex and plays a role in membrane trafficking within the endomembrane system. Human putative ATPase phospholipid transporting 9B, ATP9B, localizes to the trans-golgi network in a CDC50 protein-independent manner. It also includes Arabidopsis phospholipid flippases including ALA1, and Caenorhabditis elegans flippases, including TAT-1, the latter has been shown to facilitate the inward transport of phosphatidylserine. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319838 [Multi-domain]  Cd Length: 805  Bit Score: 107.30  E-value: 2.37e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  395 SVLQGKLTKLAVQIGKA----GLVMSAITVIILVLYFAI---------------DTFVRQKRPWLTECTPIYIQYFVKF- 454
Cdd:cd07536   220 VVYTGKETKLVMNTSNAknkvGLLDLELNRLTKALFLALvvlslvmvtlqgfwgPWYGEKNWYIKKMDTTSDNFGRNLLr 299
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  455 FIIGVTVLVvavpeglPLAVTISL----AYSVKKMMKDNNL----------VRHLDACETMGNATAICSDKTGTLTTNRM 520
Cdd:cd07536   300 FLLLFSYII-------PISLRVNLdmvkAVYAWFIMWDENMyyigndtgtvARTSTIPEELGQVVYLLTDKTGTLTQNEM 372
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  521 TAVQVYVADVHYktipeptslpsktldilvnaislnsayttkilpadkeGGlpkqvgnktecgflglvldvkrdyQTIRN 600
Cdd:cd07536   373 IFKRCHIGGVSY-------------------------------------GG------------------------QVLSF 391
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  601 QIPEeklykVYTFNSVRKSMSTVIKLP-DGSFRMYSKGASEIILkkcsrilsevgePRVfRPRDRDEMVKKVIEPMACDG 679
Cdd:cd07536   392 CILQ-----LLEFTSDRKRMSVIVRDEsTGEITLYMKGADVAIS------------PIV-SKDSYMEQYNDWLEEECGEG 453
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  680 LRTICVGYRDFPKDPEPNWE----DENNILTD---------------LTAICVVGIEDPVRPEVPDAIQKCQRAGITVRM 740
Cdd:cd07536   454 LRTLCVAKKALTENEYQEWEsrytEASLSLHDrslrvaevveslereLELLGLTAIEDRLQAGVPETIETLRKAGIKIWM 533
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  741 VTGDNINTARAIAIKCGIIHPGED--FLCIDGKEFNRR--------IRNEKGE-------------------VEQERID- 790
Cdd:cd07536   534 LTGDKQETAICIAKSCHLVSRTQDihLLRQDTSRGERAaitqhahlELNAFRRkhdvalvidgdslevalkyYRHEFVEl 613
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  791 KVWPKLRVLARSSPTDKHTLVkgiidsTLVDQRqVVAVT---GDGTNDGPALKKADVGfaMGIAGTD--VAKEASDIILT 865
Cdd:cd07536   614 ACQCPAVICCRVSPTQKARIV------TLLKQH-TGRRTlaiGDGGNDVSMIQAADCG--VGISGKEgkQASLAADYSIT 684
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  866 ddNFSSIVKAVM-WGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDS--PL-KAVQMLWVNLIMDTFASLALAT-EP 940
Cdd:cd07536   685 --QFRHLGRLLLvHGRNSYNRSAALGQYVFYKGLIISTIQAVFSFVFGFSgvPLfQGFLMVGYNVIYTMFPVFSLVIdQD 762
                         650       660       670       680
                  ....*....|....*....|....*....|....*....|....*
gi 181339464  941 PTESLLMRKP----YGRNKPLISstmTKNILGH---GVYQLVIIF 978
Cdd:cd07536   763 VKPESAMLYPqlykDLQKGRSLN---FKTFLGWvliSLYHGGILF 804
P-type_ATPase_cation cd02082
P-type cation-transporting ATPases, similar to human ATPase type 13A1-A4 (ATP13A1-A4) proteins ...
417-856 4.51e-23

P-type cation-transporting ATPases, similar to human ATPase type 13A1-A4 (ATP13A1-A4) proteins and Saccharomyces cerevisiae Ypk9p and Spf1p; Saccharomyces cerevisiae Yph9p localizes to the yeast vacuole and may play a role in sequestering heavy metal ions, its deletion confers sensitivity for growth for cadmium, manganese, nickel or selenium. Saccharomyces 1 Spf1p may mediate manganese transport into the endoplasmic reticulum. Human ATP13A2 (PARK9/CLN12) is a lysosomal transporter with zinc as the possible substrate. Mutation in the ATP13A2 gene has been linked to Parkinson's disease and Kufor-Rakeb syndrome, and to neuronal ceroid lipofuscinoses. ATP13A3/AFURS1 is a candidate gene for oculo auriculo vertebral spectrum (OAVS), being one of nine genes included in a 3q29 microduplication in a patient with OAVS. Mutation in the human ATP13A4 may be involved in a speech-language disorder. The expression of ATP13A1 has been followed during mouse development, ATP13A1 transcript expression showed an increase as development progressed, with the highest expression at the peak of neurogenesis. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319777 [Multi-domain]  Cd Length: 786  Bit Score: 106.14  E-value: 4.51e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  417 AITVIILVLYFAIDTFVRQkrpwLTECTPIYIQYFvKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLD 496
Cdd:cd02082   221 AVKFTLLLATLALIGFLYT----LIRLLDIELPPL-FIAFEFLDILTYSVPPGLPMLIAITNFVGLKRLKKNQILCQDPN 295
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  497 ACETMGNATAICSDKTGTLTTNRMTAVQVYVADVHYKTIPEPT---SLPSKTLDILVNAISLnsaytTKIlpadkEGGLP 573
Cdd:cd02082   296 RISQAGRIQTLCFDKTGTLTEDKLDLIGYQLKGQNQTFDPIQCqdpNNISIEHKLFAICHSL-----TKI-----NGKLL 365
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  574 KQVGNKTECGFLGLVLD----VKRDYQTIRNQipEEKLYKVYTFNSVRKSMSTV---IKLPDGSFRMYS--KGASEIILK 644
Cdd:cd02082   366 GDPLDVKMAEASTWDLDydheAKQHYSKSGTK--RFYIIQVFQFHSALQRMSVVakeVDMITKDFKHYAfiKGAPEKIQS 443
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  645 KCSRILSEVgeprvfrprdrdemvKKVIEPMACDGLRTICVGYRDFPKDPEPNWED------ENNIltDLTAICVVgiED 718
Cdd:cd02082   444 LFSHVPSDE---------------KAQLSTLINEGYRVLALGYKELPQSEIDAFLDlsreaqEANV--QFLGFIIY--KN 504
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  719 PVRPEVPDAIQKCQRAGITVRMVTGDNINTARAIAIKCGIIHPGEDFLCIDGkefnrrIRNEKGEVEQERIdKVWPKLRV 798
Cdd:cd02082   505 NLKPDTQAVIKEFKEACYRIVMITGDNPLTALKVAQELEIINRKNPTIIIHL------LIPEIQKDNSTQW-ILIIHTNV 577
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 181339464  799 LARSSPTDKHTLVKgiidsTLVDQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVA 856
Cdd:cd02082   578 FARTAPEQKQTIIR-----LLKESDYIVCMCGDGANDCGALKEADVGISLAEADASFA 630
P-type_ATPase_cation cd07543
P-type cation-transporting ATPases, similar to human cation-transporting ATPase type 13A1 ...
453-848 7.64e-23

P-type cation-transporting ATPases, similar to human cation-transporting ATPase type 13A1 (ATP13A1) and Saccharomyces manganese-transporting ATPase 1 Spf1p; Saccharomyces Spf1p may mediate manganese transport into the endoplasmic reticulum (ER); one consequence of deletion of SPF1 is severe ER stress. This subfamily also includes Arabidopsis thaliana MIA (Male Gametogenesis Impaired Anthers) protein which is highly abundant in the endoplasmic reticulum and small vesicles of developing pollen grains and tapetum cells. The MIA gene functionally complements a mutant in the SPF1 from Saccharomyces cerevisiae. The expression of ATP13A1 has been followed during mouse development, ATP13A1 transcript expression showed an increase as development progressed, with the highest expression at the peak of neurogenesis. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319843 [Multi-domain]  Cd Length: 804  Bit Score: 105.54  E-value: 7.64e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  453 KFFIIGVTVLVVAVPEGLP----LAVTISLAYSVKKMMKDNNLVR-----HLDACetmgnataiCSDKTGTLTTNRMtaV 523
Cdd:cd07543   260 KLFLECTLILTSVVPPELPmelsLAVNTSLIALAKLYIFCTEPFRipfagKVDIC---------CFDKTGTLTSDDL--V 328
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  524 QVYVADVHYK--TIPEPTSLPSKTLDILVNAISLNSAYTTKILpadkegGLPKQvgnKTECGFLGLVLDVKRDYQTIRNQ 601
Cdd:cd07543   329 VEGVAGLNDGkeVIPVSSIEPVETILVLASCHSLVKLDDGKLV------GDPLE---KATLEAVDWTLTKDEKVFPRSKK 399
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  602 IPEEKLYKVYTFNSVRKSMSTV--IKLPDGSFRMY---SKGASEIILKkcsrILSEVgeprvfrPRDRDEMVKKviepMA 676
Cdd:cd07543   400 TKGLKIIQRFHFSSALKRMSVVasYKDPGSTDLKYivaVKGAPETLKS----MLSDV-------PADYDEVYKE----YT 464
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  677 CDGLRTICVGYRDFPK--DPEPNWEDENNILTDLTAICVVGIEDPVRPEVPDAIQKCQRAGITVRMVTGDNINTARAIAI 754
Cdd:cd07543   465 RQGSRVLALGYKELGHltKQQARDYKREDVESDLTFAGFIVFSCPLKPDSKETIKELNNSSHRVVMITGDNPLTACHVAK 544
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  755 KCGIIhpgedflcidgkefnrriRNEKGEVEQERIDKVW-----PKLRVLARSSPTDKHTLVkgiidSTLVDQRQVVAVT 829
Cdd:cd07543   545 ELGIV------------------DKPVLILILSEEGKSNewkliPHVKVFARVAPKQKEFII-----TTLKELGYVTLMC 601
                         410
                  ....*....|....*....
gi 181339464  830 GDGTNDGPALKKADVGFAM 848
Cdd:cd07543   602 GDGTNDVGALKHAHVGVAL 620
P-type_ATPase_HM cd07544
P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily ...
192-907 4.69e-21

P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily of the heavy metal-transporting ATPases (Type IB ATPases) which transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319844 [Multi-domain]  Cd Length: 596  Bit Score: 98.93  E-value: 4.69e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  192 VVRGGQVIQLPVADILVGDIAQIKYGDLLPADGVLIQGNDLkIDESSLTGESDHVRKAADKDpmLLSGTHVMEGSGRMVV 271
Cdd:cd07544   114 RLVGGQLEEVPVEEVTVGDRLLVRPGEVVPVDGEVVSGTAT-LDESSLTGESKPVSKRPGDR--VMSGAVNGDSALTMVA 190
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  272 TAVGVNSQSGIIFTLLgaggeeeekkekkgqaledghplpdcshpsshpiatiatdgAASANTPANTslvngkmqdgnme 351
Cdd:cd07544   191 TKLAADSQYAGIVRLV-----------------------------------------KEAQANPAPF------------- 216
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  352 nnqtkVKKQDGAAAMemqplksaeggeteekekkktsvskkeksvlqgkLTKLAVQIGKAGlvmsaitviilvlyfaidt 431
Cdd:cd07544   217 -----VRLADRYAVP----------------------------------FTLLALAIAGVA------------------- 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  432 fvrqkrpWLTECTPiyiqyfVKFfiigVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDK 511
Cdd:cd07544   239 -------WAVSGDP------VRF----AAVLVVATPCPLILAAPVAIVSGMSRSSRRGILVKDGGVLEKLARAKTVAFDK 301
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  512 TGTLTTNRMTAVQVyvadvhyktipeptslpsktldilvnaislnsayttkilpadkegglpkqvgnktecgflglvldv 591
Cdd:cd07544   302 TGTLTYGQPKVVDV------------------------------------------------------------------ 315
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  592 krdyQTIRNQIPEEKLYKVYtfnSVRKSMSTVIKlpdgsfRMYSKGASEIILKKCSriLSEVGEPRvfrprdrDEMVKKV 671
Cdd:cd07544   316 ----VPAPGVDADEVLRLAA---SVEQYSSHVLA------RAIVAAARERELQLSA--VTELTEVP-------GAGVTGT 373
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  672 IEPmacdglRTICVGYRDFPKdPEPNWEDENNILTDLTAICVVGIE----------DPVRPEVPDAIQKCQRAGIT-VRM 740
Cdd:cd07544   374 VDG------HEVKVGKLKFVL-ARGAWAPDIRNRPLGGTAVYVSVDgkyagaitlrDEVRPEAKETLAHLRKAGVErLVM 446
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  741 VTGDNINTARAIAikcgiihpgeDFLCIDGkefnrrirnekgeveqeridkvwpklrVLARSSPTDKHTLVKGiidstlV 820
Cdd:cd07544   447 LTGDRRSVAEYIA----------SEVGIDE---------------------------VRAELLPEDKLAAVKE------A 483
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  821 DQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRnvyDSISKFLQFQL---TVN 897
Cdd:cd07544   484 PKAGPTIMVGDGVNDAPALAAADVGIAMGARGSTAASEAADVVILVDDLDRVVDAVAIAR---RTRRIALQSVLigmALS 560
                         730
                  ....*....|
gi 181339464  898 VVAVIVAFTG 907
Cdd:cd07544   561 IIGMLIAAFG 570
P-type_ATPase_APLT_Neo1-like cd07541
Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Neo1p and human ...
444-892 2.91e-19

Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Neo1p and human putative APLT, ATP9B; Aminophospholipid translocases (APLTs), also known as type 4 P-type ATPases, act as a flippases, and translocate specific phospholipids from the exoplasmic leaflet to the cytoplasmic leaflet of biological membranes. The yeast Neo1 gene is an essential gene; Neo1p localizes to the endoplasmic reticulum and the Golgi complex and plays a role in membrane trafficking within the endomembrane system. Also included in this sub family is human putative ATPase phospholipid transporting 9B, ATP9B, which localizes to the trans-golgi network in a CDC50 protein-independent manner. Levels of ATP9B, along with levels of other ATPase genes, may contribute to expressivity of and atypical presentations of Hailey-Hailey disease (HHD), and the ATP9B gene has recently been identified as a putative Alzheimer's disease loci. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319841 [Multi-domain]  Cd Length: 792  Bit Score: 94.01  E-value: 2.91e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  444 TPIYIQYFvKFFIIGVTVLVVAvpeglpLAVTISLAYSV--KKMMKDNNL----VRHLDACETMGNATAICSDKTGTLTT 517
Cdd:cd07541   267 GPWYIYLF-RFLILFSSIIPIS------LRVNLDMAKIVysWQIEHDKNIpgtvVRTSTIPEELGRIEYLLSDKTGTLTQ 339
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  518 NRMtavqvyvadvHYKTIpeptslpsktldilvnaislnsayttkilpadkegglpkqvgnktecgFLGLVldvkrdyqT 597
Cdd:cd07541   340 NEM----------VFKKL------------------------------------------------HLGTV--------S 353
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  598 IRNQIPEEKLYKVYTFNSVRKSMSTVIKLP-DGSFRMYSKGASEI---ILKKCSRILSEVGEprvfrprdrdemvkkvie 673
Cdd:cd07541   354 YGGQNLNYEILQIFPFTSESKRMGIIVREEkTGEITFYMKGADVVmskIVQYNDWLEEECGN------------------ 415
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  674 pMACDGLRTICVGYRDFPKDPEPNWEDENN-------------------ILTDLTAICVVGIEDPVRPEVPDAIQKCQRA 734
Cdd:cd07541   416 -MAREGLRTLVVAKKKLSEEEYQAFEKRYNaaklsihdrdlkvaevvesLERELELLCLTGVEDKLQEDVKPTLELLRNA 494
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  735 GITVRMVTGDNINTARAIAIKCGIIHPGEDF-----LCIDGKEFN-----RRIRNEK------------GEVEQERIDKV 792
Cdd:cd07541   495 GIKIWMLTGDKLETATCIAKSSKLVSRGQYIhvfrkVTTREEAHLelnnlRRKHDCAlvidgeslevclKYYEHEFIELA 574
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  793 WPKLRVLA-RSSPTDKHTLVKGIIDSTlvdQRQVVAVtGDGTNDGPALKKADVGfaMGIAGTDvAKEAS---DIILTDdn 868
Cdd:cd07541   575 CQLPAVVCcRCSPTQKAQIVRLIQKHT---GKRTCAI-GDGGNDVSMIQAADVG--VGIEGKE-GKQASlaaDFSITQ-- 645
                         490       500
                  ....*....|....*....|....*
gi 181339464  869 FSSIVKAVMW-GRNVYDSISKFLQF 892
Cdd:cd07541   646 FSHIGRLLLWhGRNSYKRSAKLAQF 670
Cation_ATPase pfam13246
Cation transport ATPase (P-type); This domain is found in cation transport ATPases, including ...
555-649 3.41e-19

Cation transport ATPase (P-type); This domain is found in cation transport ATPases, including phospholipid-transporting ATPases, calcium-transporting ATPases, and sodium-potassium ATPases.


Pssm-ID: 463817 [Multi-domain]  Cd Length: 91  Bit Score: 83.42  E-value: 3.41e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   555 LNSAyttkILPADKEGGLPKQVGNKTECGFLGLVLDVKRDYQTIRNQIPEEKlykVYTFNSVRKSMSTVIKLP-DGSFRM 633
Cdd:pfam13246    3 CNSA----AFDENEEKGKWEIVGDPTESALLVFAEKMGIDVEELRKDYPRVA---EIPFNSDRKRMSTVHKLPdDGKYRL 75
                           90
                   ....*....|....*.
gi 181339464   634 YSKGASEIILKKCSRI 649
Cdd:pfam13246   76 FVKGAPEIILDRCTTI 91
P-type_ATPase_K cd02078
potassium-transporting ATPase ATP-binding subunit, KdpB, a subunit of the prokaryotic ...
497-880 1.23e-17

potassium-transporting ATPase ATP-binding subunit, KdpB, a subunit of the prokaryotic high-affinity potassium uptake system KdpFABC; similar to Escherichia coli KdpB; KdpFABC is a prokaryotic high-affinity potassium uptake system. It is expressed under K(+) limiting conditions when the other potassium transport systems are not able to provide a sufficient flow of K(+) into the bacteria. The KdpB subunit represents the catalytic subunit performing ATP hydrolysis. KdpB is comprised of four domains: the transmembrane domain, the nucleotide-binding domain, the phosphorylation domain, and the actuator domain. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319773 [Multi-domain]  Cd Length: 667  Bit Score: 88.47  E-value: 1.23e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  497 ACETMGNATAICSDKTGTLTT-NRMTavqvyvadvhYKTIPeptsLPSKTLDILVNAISLNSAYTTKilpadKEGglpkq 575
Cdd:cd02078   282 AVEAAGDVDTLLLDKTGTITLgNRQA----------TEFIP----VGGVDEKELADAAQLASLADET-----PEG----- 337
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  576 vgnktecgfLGLVLDVKRDYQTIRNQIPEEklYKVYTFnSVRKSMSTViKLPDGsfRMYSKGASEIILKKCSRILSEVge 655
Cdd:cd02078   338 ---------RSIVILAKQLGGTERDLDLSG--AEFIPF-SAETRMSGV-DLPDG--TEIRKGAVDAIRKYVRSLGGSI-- 400
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  656 prvfrPRDRDEMVKKVIE----PMAcdglrtICVGYRdfpkdpepnwedenniltdltAICVVGIEDPVRPEVPDAIQKC 731
Cdd:cd02078   401 -----PEELEAIVEEISKqggtPLV------VAEDDR---------------------VLGVIYLKDIIKPGIKERFAEL 448
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  732 QRAGITVRMVTGDNINTARAIAIKCGIihpgEDFLcidgkefnrrirnekgeveqeridkvwpklrvlARSSPTDKHTLV 811
Cdd:cd02078   449 RKMGIKTVMITGDNPLTAAAIAAEAGV----DDFL---------------------------------AEAKPEDKLELI 491
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 181339464  812 KGIidstlVDQRQVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTDDNFSSIVKAVMWGR 880
Cdd:cd02078   492 RKE-----QAKGKLVAMTGDGTNDAPALAQADVGVAMN-SGTQAAKEAGNMVDLDSDPTKLIEVVEIGK 554
P-type_ATPase_Pb_Zn_Cd2-like cd07546
P-type heavy metal-transporting ATPase, similar to Escherichia coli ZntA which is selective ...
191-938 2.17e-17

P-type heavy metal-transporting ATPase, similar to Escherichia coli ZntA which is selective for Pb(2+), Zn(2+), and Cd(2+); Escherichia coli ZntA mediates resistance to toxic levels of selected divalent metal ions. ZntA has the highest selectivity for Pb(2+), followed by Zn(2+) and Cd(2+); it also shows low levels of activity with Cu(2+), Ni(2+), and Co(2+). It is upregulated by the transcription factor ZntR at high zinc concentrations. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319846 [Multi-domain]  Cd Length: 597  Bit Score: 87.46  E-value: 2.17e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  191 QVVRGGQVIQLPVADILVGDIAQIKYGDLLPADGVLIQGNDlKIDESSLTGESDHVRKAAdkdpmllsGTHVMEGSgrmv 270
Cdd:cd07546   102 LREENGERREVPADSLRPGDVIEVAPGGRLPADGELLSGFA-SFDESALTGESIPVEKAA--------GDKVFAGS---- 168
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  271 vtavgVNSqsgiiftllgaggeeeekkekkgqaleDGhplpdcshpsshpIATIATDGAASANTPANTslvngkmqdgnm 350
Cdd:cd07546   169 -----INV---------------------------DG-------------VLRIRVTSAPGDNAIDRI------------ 191
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  351 ennqtkvkkqdgaaameMQPLKSAeggeteekekkktsvsKKEKSVLQGKLTKLAVQIGKAGLVMSAITVIILVLYFAid 430
Cdd:cd07546   192 -----------------LHLIEEA----------------EERRAPIERFIDRFSRWYTPAIMAVALLVIVVPPLLFG-- 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  431 tfvrqkRPWLTEctpIYIqyfvkffiiGVTVLVVAVPEGL----PLAVTISLAYSVKKMMkdnnLVRHLDACETMGNATA 506
Cdd:cd07546   237 ------ADWQTW---IYR---------GLALLLIGCPCALvistPAAITSGLAAAARRGA----LIKGGAALEQLGRVTT 294
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  507 ICSDKTGTLTTNRMTavqvyVADVHYKTIPEPTSLPSktldiLVNAISLNSAY--TTKILP-ADKEGGLPKQVGNKTECG 583
Cdd:cd07546   295 VAFDKTGTLTRGKPV-----VTDVVPLTGISEAELLA-----LAAAVEMGSSHplAQAIVArAQAAGLTIPPAEEARALV 364
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  584 FLGlvldvkrdyqtIRNQIPEEKLykvytfnsvrksmstviklpdgsfrmyskgaseiilkkcsrilsEVGEPRVFRPRD 663
Cdd:cd07546   365 GRG-----------IEGQVDGERV--------------------------------------------LIGAPKFAADRG 389
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  664 RDEmVKKVIEPMACDGlRTICVgyrdfpkdpepnwedennILTDLTAICVVGIEDPVRPEVPDAIQKCQRAGITVRMVTG 743
Cdd:cd07546   390 TLE-VQGRIAALEQAG-KTVVV------------------VLANGRVLGLIALRDELRPDAAEAVAELNALGIKALMLTG 449
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  744 DNINTARAIAIKCGIihpgeDFlcidgkefnrrirneKGEVeqeridkvwpklrvlarsSPTDKhtlVKGIidsTLVDQR 823
Cdd:cd07546   450 DNPRAAAAIAAELGL-----DF---------------RAGL------------------LPEDK---VKAV---RELAQH 485
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  824 QVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIV 903
Cdd:cd07546   486 GPVAMVGDGINDAPAMKAASIGIAMG-SGTDVALETADAALTHNRLGGVAAMIELSRATLANIRQNITIALGLKAVFLVT 564
                         730       740       750
                  ....*....|....*....|....*....|....*
gi 181339464  904 AFTGacITQdsplkavqmLWVNLIMDTFASlALAT 938
Cdd:cd07546   565 TLLG--ITG---------LWLAVLADTGAT-VLVT 587
P-type_ATPase-Cd_Zn_Co_like cd07548
P-type heavy metal-transporting ATPase, similar to Bacillus subtilis CadA which appears to ...
716-880 4.43e-16

P-type heavy metal-transporting ATPase, similar to Bacillus subtilis CadA which appears to transport cadmium, zinc and cobalt but not copper out of the cell; Bacillus subtilis CadA/YvgW appears to transport cadmium, zinc and cobalt but not copper, out of the cell. Functions in metal ion resistance and cellular metal ion homeostasis. CadA/YvgW is also important for sporulation in B. subtilis, the significant specific expression of the cadA/yvgW gene during the late stage of sporulation, is controlled by forespore-specific sigma factor, sigma G, and mother cell-specific sigma factor, sigma E. This subfamily also includes Helicobacter pylori CadA an essential resistance pump with ion specificity towards Cd(2+), Zn(2+) and Co(2+), and Zn-transporting ATPase, ZiaA(N) in Synechocystis PCC 6803. Transcription of ziaA is induced by Zn under the control of the Zn responsive repressor ZiaR. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319847 [Multi-domain]  Cd Length: 604  Bit Score: 83.44  E-value: 4.43e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  716 IEDPVRPEVPDAIQKCQRAGIT-VRMVTGDNINTARAIAIKCGIihpgedflcidgkefnrrirnekgeveqeriDKVWP 794
Cdd:cd07548   426 ISDEIKEDAKEAIKGLKELGIKnLVMLTGDRKSVAEKVAKKLGI-------------------------------DEVYA 474
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  795 KLrvlarsSPTDKHTLVKGIIDSTlvdqRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVK 874
Cdd:cd07548   475 EL------LPEDKVEKVEELKAES----KGKVAFVGDGINDAPVLARADVGIAMGGLGSDAAIEAADVVLMNDEPSKVAE 544

                  ....*.
gi 181339464  875 AVMWGR 880
Cdd:cd07548   545 AIKIAR 550
Cation_ATPase_N pfam00690
Cation transporter/ATPase, N-terminus; Members of this families are involved in Na+/K+, H+/K+, ...
47-114 2.44e-15

Cation transporter/ATPase, N-terminus; Members of this families are involved in Na+/K+, H+/K+, Ca++ and Mg++ transport.


Pssm-ID: 459907 [Multi-domain]  Cd Length: 68  Bit Score: 71.82  E-value: 2.44e-15
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 181339464    47 YGGTEGLCQRLKTSPTEGLAglATDLDKRKEVFGRNLIPPKKPKTFLQLVWEALQDVTLIILEIAALI 114
Cdd:pfam00690    3 ALSVEEVLKKLGTDLEKGLT--EAEAEKRLKKYGPNELPEKKPKSLWKLFLRQFKDPLIIILLIAAIV 68
zntA PRK11033
zinc/cadmium/mercury/lead-transporting ATPase; Provisional
704-865 2.59e-15

zinc/cadmium/mercury/lead-transporting ATPase; Provisional


Pssm-ID: 236827 [Multi-domain]  Cd Length: 741  Bit Score: 81.19  E-value: 2.59e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  704 ILTDLTAICVVGIEDPVRPEVPDAIQKCQRAGITVRMVTGDNINTARAIAIKCGIihpgeDFlcidgkefnrrirnekge 783
Cdd:PRK11033  553 VLRNDDVLGLIALQDTLRADARQAISELKALGIKGVMLTGDNPRAAAAIAGELGI-----DF------------------ 609
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  784 veqeridkvwpklrvlaRSS--PTDKhtlVKGIidsTLVDQRQVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASD 861
Cdd:PRK11033  610 -----------------RAGllPEDK---VKAV---TELNQHAPLAMVGDGINDAPAMKAASIGIAMG-SGTDVALETAD 665

                  ....
gi 181339464  862 IILT 865
Cdd:PRK11033  666 AALT 669
copA PRK10671
copper-exporting P-type ATPase CopA;
707-876 6.34e-15

copper-exporting P-type ATPase CopA;


Pssm-ID: 182635 [Multi-domain]  Cd Length: 834  Bit Score: 80.17  E-value: 6.34e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  707 DLTAICVVGIEDPVRPEVPDAIQKCQRAGITVRMVTGDNINTARAIAIKCGIIhpgedflcidgkefnrrirnekgeveq 786
Cdd:PRK10671  638 DGKAAALLAIRDPLRSDSVAALQRLHKAGYRLVMLTGDNPTTANAIAKEAGID--------------------------- 690
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  787 eridkvwpklRVLARSSPTDKHTLVKgiidsTLVDQRQVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTD 866
Cdd:PRK10671  691 ----------EVIAGVLPDGKAEAIK-----RLQSQGRQVAMVGDGINDAPALAQADVGIAMG-GGSDVAIETAAITLMR 754
                         170
                  ....*....|
gi 181339464  867 DNFSSIVKAV 876
Cdd:PRK10671  755 HSLMGVADAL 764
kdpB TIGR01497
K+-transporting ATPase, B subunit; This model describes the P-type ATPase subunit of the ...
434-908 2.18e-14

K+-transporting ATPase, B subunit; This model describes the P-type ATPase subunit of the complex responsible for translocating potassium ions across biological membranes in microbes. In E. coli and other species, this complex consists of the proteins KdpA, KdpB, KdpC and KdpF. KdpB is the ATPase subunit, while KdpA is the potassium-ion translocating subunit. The function of KdpC is unclear, although cit has been suggested to couple the ATPase subunit to the ion-translocating subunit, while KdpF serves to stabilize the complex. The potassium P-type ATPases have been characterized as Type IA based on a phylogenetic analysis which places this clade closest to the heavy-metal translocating ATPases (Type IB). Others place this clade closer to the Na+/K+ antiporter type (Type IIC) based on physical characteristics. This model is very clear-cut, with a strong break between trusted hits and noise. All members of the seed alignment, from Clostridium, Anabaena and E. coli are in the characterized table. One sequence above trusted, OMNI|NTL01TA01282, is apparently mis-annotated in the primary literature, but properly annotated by TIGR. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 130561 [Multi-domain]  Cd Length: 675  Bit Score: 78.00  E-value: 2.18e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   434 RQKRPWLTECTPIYIQYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSV-------------------KKMMKDNNLVRH 494
Cdd:TIGR01497  210 RRKTPNEIALTILLIALTLVFLLVTATLWPFAAYGGNAISVTVLVALLVclipttiggllsaigiagmDRVLGFNVIATS 289
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   495 LDACETMGNATAICSDKTGTLTT-NRMTAVQVYVADVHYKTIPEPTSLPSKTLDIlvnaislnsayttkilpadKEGGLP 573
Cdd:TIGR01497  290 GRAVEACGDVDTLLLDKTGTITLgNRLASEFIPAQGVDEKTLADAAQLASLADDT-------------------PEGKSI 350
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   574 KQVGNKtecgfLGLVLDVKRdYQTIRnqipeeklykvYTFNSVRKSMSTvIKLPDGsfRMYSKGASEIILKKcsrilseV 653
Cdd:TIGR01497  351 VILAKQ-----LGIREDDVQ-SLHAT-----------FVEFTAQTRMSG-INLDNG--RMIRKGAVDAIKRH-------V 403
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   654 GEPRVFRPRDRDEMVKKVIE----PMAcdglrtICVGyrdfpkdpepnwedeNNILTdltaicVVGIEDPVRPEVPDAIQ 729
Cdd:TIGR01497  404 EANGGHIPTDLDQAVDQVARqggtPLV------VCED---------------NRIYG------VIYLKDIVKGGIKERFA 456
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   730 KCQRAGITVRMVTGDNINTARAIAIKCGIihpgEDFLcidgkefnrrirnekgeveqeridkvwpklrvlARSSPTDKHT 809
Cdd:TIGR01497  457 QLRKMGIKTIMITGDNRLTAAAIAAEAGV----DDFI---------------------------------AEATPEDKIA 499
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   810 LVKgiidsTLVDQRQVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKF 889
Cdd:TIGR01497  500 LIR-----QEQAEGKLVAMTGDGTNDAPALAQADVGVAMN-SGTQAAKEAANMVDLDSDPTKLIEVVHIGKQLLITRGAL 573
                          490       500
                   ....*....|....*....|...
gi 181339464   890 LQFQLTVNVV---AVI-VAFTGA 908
Cdd:TIGR01497  574 TTFSIANDVAkyfAIIpAIFAAA 596
P-type_ATPase_FixI-like cd02092
Rhizobium meliloti FixI and related proteins; belongs to P-type heavy metal-transporting ...
715-918 7.96e-12

Rhizobium meliloti FixI and related proteins; belongs to P-type heavy metal-transporting ATPase subfamily; FixI may be a pump of a specific cation involved in symbiotic nitrogen fixation. The Rhizobium fixI gene is part of an operon conserved among rhizobia, fixGHIS. FixG, FixH, FixI, and FixS may participate in a membrane-bound complex coupling the FixI cation pump with a redox process catalyzed by FixG, an iron-sulfur protein. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319782 [Multi-domain]  Cd Length: 605  Bit Score: 69.69  E-value: 7.96e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  715 GIEDPVRPEVPDAIQKCQRAGITVRMVTGDNINTARAIAIKCGIIHpgedflcidgkefnrrirnekgeveqeridkvwp 794
Cdd:cd02092   430 PFEDRPRPDAREAISALRALGLSVEILSGDREPAVRALARALGIED---------------------------------- 475
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  795 klrVLARSSPTDKHTLVkgiidSTLVDQRQVVAVTGDGTNDGPALKKADVGFAMGIAgTDVAKEASDIILTDDNFSSIVK 874
Cdd:cd02092   476 ---WRAGLTPAEKVARI-----EELKAQGRRVLMVGDGLNDAPALAAAHVSMAPASA-VDASRSAADIVFLGDSLAPVPE 546
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 181339464  875 AVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGacitQDSPLKA 918
Cdd:cd02092   547 AIEIARRARRLIRQNFALAIGYNVIAVPLAIAG----YVTPLIA 586
P-type_ATPase_HM cd07553
P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily ...
419-918 1.26e-11

P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily of the heavy metal-transporting ATPases (Type IB ATPases) which transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319851 [Multi-domain]  Cd Length: 610  Bit Score: 69.08  E-value: 1.26e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  419 TVIILVLYFAIDTFvrqkrpWLTectpIYIQYFVKFFIigvTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDAC 498
Cdd:cd07553   246 TVIALLIAVAGFGV------WLA----IDLSIALKVFT---SVLIVACPCALALATPFTDEIALARLKKKGVLIKNASSL 312
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  499 ETMGNATAICSDKTGTLTTNRMTAVQVyvadvhyktIPEPTSLpsktldilvnaISLNSAYTTkilpadkEGGLPKQVGN 578
Cdd:cd07553   313 ERLSRVRTIVFDKTGTLTRGKSSFVMV---------NPEGIDR-----------LALRAISAI-------EAHSRHPISR 365
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  579 ktecgflglvldvkrdyqTIRNQIPEEklykvytfNSVRKSMSTVIKLPDGSFRMYSKGaSEIILKKcsrilsevgeprv 658
Cdd:cd07553   366 ------------------AIREHLMAK--------GLIKAGASELVEIVGKGVSGNSSG-SLWKLGS------------- 405
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  659 frprdrdemvkkviepmACDGLRTIcvgyrdfpkdpepnwEDENNILTDLTAICVVGIEDPVRPEVPDAIQKCQRAGITV 738
Cdd:cd07553   406 -----------------APDACGIQ---------------ESGVVIARDGRQLLDLSFNDLLRPDSNREIEELKKGGLSI 453
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  739 RMVTGDNINTARAIAikcgiihpgeDFLCIDGKEfnrrirnekgeveqeridkvwpklrVLARSSPTDKHTLVKGIidst 818
Cdd:cd07553   454 AILSGDNEEKVRLVG----------DSLGLDPRQ-------------------------LFGNLSPEEKLAWIESH---- 494
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  819 lvdQRQVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNV 898
Cdd:cd07553   495 ---SPENTLMVGDGANDALALASAFVGIAVA-GEVGVSLEAADIYYAGNGIGGIRDLLTLSKQTIKAIKGLFAFSLLYNL 570
                         490       500
                  ....*....|....*....|
gi 181339464  899 VAVIVAFTGACitqdSPLKA 918
Cdd:cd07553   571 VAIGLALSGWI----SPLVA 586
PLN03190 PLN03190
aminophospholipid translocase; Provisional
455-752 1.43e-11

aminophospholipid translocase; Provisional


Pssm-ID: 215623 [Multi-domain]  Cd Length: 1178  Bit Score: 69.16  E-value: 1.43e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  455 FIIGVTVLVVAVPEGLPLA---VTISLAYSvkkMMKDNNL----------VRHLDACETMGNATAICSDKTGTLTTNRMT 521
Cdd:PLN03190  394 FLMSVIVFQIMIPISLYISmelVRVGQAYF---MIRDDQMydeasnsrfqCRALNINEDLGQIKYVFSDKTGTLTENKME 470
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  522 AVQVYVADVHYKTIPEPTSLPSKTLDILVNAISLNSAYTTKILPADKEggLPKQvGNKTECG------FLGL-------- 587
Cdd:PLN03190  471 FQCASIWGVDYSDGRTPTQNDHAGYSVEVDGKILRPKMKVKVDPQLLE--LSKS-GKDTEEAkhvhdfFLALaacntivp 547
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  588 -VLDVKRD-------YQtirNQIPEEK---------------------------------LYKVYTFNSVRKSMSTVIKL 626
Cdd:PLN03190  548 iVVDDTSDptvklmdYQ---GESPDEQalvyaaaaygfmliertsghividihgerqrfnVLGLHEFDSDRKRMSVILGC 624
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  627 PDGSFRMYSKGASEIILKKCSRILSEvgepRVFRPrdrdemVKKVIEPMACDGLRTICVGYRDFPKDPEPNWEDE----- 701
Cdd:PLN03190  625 PDKTVKVFVKGADTSMFSVIDRSLNM----NVIRA------TEAHLHTYSSLGLRTLVVGMRELNDSEFEQWHFSfeaas 694
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 181339464  702 --------------NNILTDLTAICVVGIEDPVRPEVPDAIQKCQRAGITVRMVTGDNINTARAI 752
Cdd:PLN03190  695 taligraallrkvaSNVENNLTILGASAIEDKLQQGVPEAIESLRTAGIKVWVLTGDKQETAISI 759
Cation_ATPase_N smart00831
Cation transporter/ATPase, N-terminus; This entry represents the conserved N-terminal region ...
51-118 3.91e-11

Cation transporter/ATPase, N-terminus; This entry represents the conserved N-terminal region found in several classes of cation-transporting P-type ATPases, including those that transport H+, Na+, Ca2+, Na+/K+, and H+/K+. In the H+/K+- and Na+/K+-exchange P-ATPases, this domain is found in the catalytic alpha chain. In gastric H+/K+-ATPases, this domain undergoes reversible sequential phosphorylation inducing conformational changes that may be important for regulating the function of these ATPases.


Pssm-ID: 214842 [Multi-domain]  Cd Length: 75  Bit Score: 59.90  E-value: 3.91e-11
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 181339464     51 EGLCQRLKTSPTEGLAglATDLDKRKEVFGRNLIPPKKPKTFLQLVWEALQDVTLIILEIAALISLGL 118
Cdd:smart00831   10 EEVLERLQTDLEKGLS--SEEAARRLERYGPNELPPPKKTSPLLRFLRQFHNPLIYILLAAAVLSALL 75
PRK14010 PRK14010
K(+)-transporting ATPase subunit B;
701-898 5.50e-10

K(+)-transporting ATPase subunit B;


Pssm-ID: 184448 [Multi-domain]  Cd Length: 673  Bit Score: 63.57  E-value: 5.50e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  701 ENNILtdltaICVVGIEDPVRPEVPDAIQKCQRAGITVRMVTGDNINTARAIAIKCGIIhpgedflcidgkefnrrirne 780
Cdd:PRK14010  428 EDNEI-----LGVIYLKDVIKDGLVERFRELREMGIETVMCTGDNELTAATIAKEAGVD--------------------- 481
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  781 kgeveqeridkvwpklRVLARSSPTDKHTLVKgiidsTLVDQRQVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEAS 860
Cdd:PRK14010  482 ----------------RFVAECKPEDKINVIR-----EEQAKGHIVAMTGDGTNDAPALAEANVGLAMN-SGTMSAKEAA 539
                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 181339464  861 DIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNV 898
Cdd:PRK14010  540 NLIDLDSNPTKLMEVVLIGKQLLMTRGSLTTFSIANDI 577
Hydrolase pfam00702
haloacid dehalogenase-like hydrolase; This family is structurally different from the alpha ...
699-843 3.04e-09

haloacid dehalogenase-like hydrolase; This family is structurally different from the alpha/beta hydrolase family (pfam00561). This family includes L-2-haloacid dehalogenase, epoxide hydrolases and phosphatases. The structure of the family consists of two domains. One is an inserted four helix bundle, which is the least well conserved region of the alignment, between residues 16 and 96 of Swiss:P24069. The rest of the fold is composed of the core alpha/beta domain. Those members with the characteriztic DxD triad at the N-terminus are probably phosphatidylglycerolphosphate (PGP) phosphatases involved in cardiolipin biosynthesis in the mitochondria.


Pssm-ID: 459910 [Multi-domain]  Cd Length: 191  Bit Score: 57.98  E-value: 3.04e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   699 EDENNILTDLTAICVVGIEDPVRPEVPDAIQKCQRAGITVRMVTGDNINTARAIAIKCGIIHPGEDFLCIDGKEFnrrir 778
Cdd:pfam00702   78 EGLTVVLVELLGVIALADELKLYPGAAEALKALKERGIKVAILTGDNPEAAEALLRLLGLDDYFDVVISGDDVGV----- 152
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 181339464   779 nekgeveqeridkvwpklrvlARSSPTDKHTLVKgiidsTLVDQRQVVAVTGDGTNDGPALKKAD 843
Cdd:pfam00702  153 ---------------------GKPKPEIYLAALE-----RLGVKPEEVLMVGDGVNDIPAAKAAG 191
Cof COG0561
Hydroxymethylpyrimidine pyrophosphatase and other HAD family phosphatases [Coenzyme transport ...
722-868 9.71e-06

Hydroxymethylpyrimidine pyrophosphatase and other HAD family phosphatases [Coenzyme transport and metabolism, General function prediction only];


Pssm-ID: 440327 [Multi-domain]  Cd Length: 192  Bit Score: 47.82  E-value: 9.71e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  722 PEVPDAIQKCQRAGITVRMVTGDNINTARAIAIKCGIIHPgedFLCIDGKEfnrrIRNEKGEV------EQERIDKVWPK 795
Cdd:COG0561    22 PRTKEALRRLREKGIKVVIATGRPLRSALPLLEELGLDDP---LITSNGAL----IYDPDGEVlyerplDPEDVREILEL 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  796 LR-------VLARSSPT---------DKHTLVKGIIDSTLVDQRQVVAVtGDGTNDGPALKKADVGFAMGIAgTDVAKEA 859
Cdd:COG0561    95 LRehglhlqVVVRSGPGfleilpkgvSKGSALKKLAERLGIPPEEVIAF-GDSGNDLEMLEAAGLGVAMGNA-PPEVKAA 172

                  ....*....
gi 181339464  860 SDIIlTDDN 868
Cdd:COG0561   173 ADYV-TGSN 180
Cof-subfamily TIGR00099
Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; This subfamily of ...
820-868 1.13e-03

Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; This subfamily of sequences falls within the Class-IIB subfamily (TIGR01484) of the Haloacid Dehalogenase superfamily of aspartate-nucleophile hydrolases. The use of the name "Cof" as an identifier here is arbitrary and refers to the E. coli Cof protein. This subfamily is notable for the large number of recent paralogs in many species. Listeria, for instance, has 12, Clostridium, Lactococcus and Streptococcus pneumoniae have 8 each, Enterococcus and Salmonella have 7 each, and Bacillus subtilus, Mycoplasma, Staphylococcus and E. coli have 6 each. This high degree of gene duplication is limited to the gamma proteobacteria and low-GC gram positive lineages. The profusion of genes in this subfamily is not coupled with a high degree of divergence, so it is impossible to determine an accurate phylogeny at the equivalog level. Considering the relationship of this subfamily to the other known members of the HAD-IIB subfamily (TIGR01484), sucrose and trehalose phosphatases and phosphomannomutase, it seems a reasonable hypothesis that these enzymes act on phosphorylated sugars. Possibly the diversification of genes in this subfamily represents the diverse sugars and polysaccharides that various bacteria find in their biological niches. The members of this subfamily are restricted almost exclusively to bacteria (one sequences from S. pombe scores above trusted, while another is between trusted and noise). It is notable that no archaea are found in this group, the closest relations to the archaea found here being two Deinococcus sequences. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 272905 [Multi-domain]  Cd Length: 256  Bit Score: 42.26  E-value: 1.13e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 181339464   820 VDQRQVVAVtGDGTNDGPALKKADVGFAMGIAgTDVAKEASDIIlTDDN 868
Cdd:TIGR00099  202 ISLEDVIAF-GDGMNDIEMLEAAGYGVAMGNA-DEELKALADYV-TDSN 247
Hydrolase_3 pfam08282
haloacid dehalogenase-like hydrolase; This family contains haloacid dehalogenase-like ...
723-875 1.67e-03

haloacid dehalogenase-like hydrolase; This family contains haloacid dehalogenase-like hydrolase enzymes.


Pssm-ID: 429897 [Multi-domain]  Cd Length: 255  Bit Score: 41.84  E-value: 1.67e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   723 EVPDAIQKCQRAGITVRMVTGDN--INTARAIAIKCGIIHPGEDFLCIDGKEFNR--------RIRNEKGEVEQ--ERID 790
Cdd:pfam08282   83 AVKEIIEYLKENNLEILLYTDDGvyILNDNELEKILKELNYTKSFVPEIDDFELLededinkiLILLDEEDLDEleKELK 162
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464   791 KVWPKLRVLARSSP---------TDKHTLVKGIIDSTLVDQRQVVAVtGDGTNDGPALKKADVGFAMGIAgTDVAKEASD 861
Cdd:pfam08282  163 ELFGSLITITSSGPgyleimpkgVSKGTALKALAKHLNISLEEVIAF-GDGENDIEMLEAAGLGVAMGNA-SPEVKAAAD 240
                          170
                   ....*....|....
gi 181339464   862 IILTDDNFSSIVKA 875
Cdd:pfam08282  241 YVTDSNNEDGVAKA 254
HAD_like cd01427
Haloacid dehalogenase-like hydrolases; The haloacid dehalogenase-like (HAD) superfamily ...
724-844 2.63e-03

Haloacid dehalogenase-like hydrolases; The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others. This superfamily includes a variety of enzymes that catalyze the cleavage of substrate C-Cl, P-C, and P-OP bonds via nucleophilic substitution pathways. All of which use a nucleophilic aspartate in their phosphoryl transfer reaction. They catalyze nucleophilic substitution reactions at phosphorus or carbon centers, using a conserved Asp carboxylate in covalent catalysis. All members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. Members of this superfamily are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.


Pssm-ID: 319763 [Multi-domain]  Cd Length: 106  Bit Score: 38.92  E-value: 2.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 181339464  724 VPDAIQKCQRAGITVRMVTGDNINTARAIAIKCGIIHPGEDFLCIDGKEfnrrirnekgeveqerIDKVWPKlrvlarss 803
Cdd:cd01427    12 AVELLKRLRAAGIKLAIVTNRSREALRALLEKLGLGDLFDGIIGSDGGG----------------TPKPKPK-------- 67
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 181339464  804 ptdkhtLVKGIIDSTLVDQRQVVAVtGDGTNDGPALKKADV 844
Cdd:cd01427    68 ------PLLLLLLKLGVDPEEVLFV-GDSENDIEAARAAGG 101
HAD_Pase cd07516
phosphatase, similar to Escherichia coli Cof and Thermotoga maritima TM0651; belongs to the ...
820-868 4.22e-03

phosphatase, similar to Escherichia coli Cof and Thermotoga maritima TM0651; belongs to the haloacid dehalogenase-like superfamily; Escherichia coli Cof is involved in the hydrolysis of HMP-PP (4-amino-2-methyl-5-hydroxymethylpyrimidine pyrophosphate, an intermediate in thiamin biosynthesis), Cof also has phosphatase activity against the coenzymes pyridoxal phosphate (PLP) and FMN. Thermotoga maritima TM0651 acts as a phosphatase with a phosphorylated carbohydrate molecule as a possible substrate. Escherichia coli YbhA is also a member of this family and catalyzes the dephosphorylation of PLP, YbhA can also hydrolyze erythrose-4-phosphate and fructose-1,6-bis-phosphate. Members of this family belong to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.


Pssm-ID: 319818 [Multi-domain]  Cd Length: 253  Bit Score: 40.27  E-value: 4.22e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 181339464  820 VDQRQVVAVtGDGTNDGPALKKADVGFAMGIAgTDVAKEASDIIlTDDN 868
Cdd:cd07516   197 ISLEEVIAF-GDNENDLSMLEYAGLGVAMGNA-IDEVKEAADYV-TLTN 242
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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