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Conserved domains on  [gi|165932350|ref|NP_001107034|]
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copper homeostasis protein cutC homolog isoform 1 [Mus musculus]

Protein Classification

copper homeostasis protein CutC( domain architecture ID 10006961)

copper homeostasis protein CutC is induced late during copper exposure and may be involved in modifying intracellular copper content

CATH:  3.20.20.380
Gene Ontology:  GO:0005507
PubMed:  19878721|21362400
SCOP:  4001982

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
CutC COG3142
Copper homeostasis protein CutC [Inorganic ion transport and metabolism];
26-270 6.25e-121

Copper homeostasis protein CutC [Inorganic ion transport and metabolism];


:

Pssm-ID: 442376  Cd Length: 240  Bit Score: 345.23  E-value: 6.25e-121
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 165932350  26 LMEVCVDSVESAVNAERGGAGRIELCSGLLEGGTTPSMGVLQVVKQSVQIPVFVMIRPRGGDFLYSDREVEVMKADIRLA 105
Cdd:COG3142    3 LLEVCVDSVEDALAAEAGGADRIELCSALAEGGLTPSYGLIKAAREAVDIPVHVMIRPRGGDFVYSDDEFEVMLRDIRAA 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 165932350 106 KLYGADGLVFGALTEDGHIDKELCLSLVALCRPLPVTFHRAFDMVHDPMAALETLLTLGFERVLTSGCDSSALEGLPLIK 185
Cdd:COG3142   83 RELGADGVVFGALTPDGEIDLERLKRLVEAAGGLPVTFHRAFDVVPDPLEALEQLIDLGVDRVLTSGGAATAEEGLDLLK 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 165932350 186 QLIDQAKGRIVVMPGGGITDKNLQRILEGSGATEFHCSARSSRDSGMkfRNSSVAMGaslahSEYSLKVTDVTKVRTLNA 265
Cdd:COG3142  163 ELVEQAGGRIEIMAGGGVRPENVPELVAATGVREVHLSARVRVPSSM--TNPGVSMG-----GEFSRSPTDAEKVRALRA 235

                 ....*
gi 165932350 266 IAKDV 270
Cdd:COG3142  236 ALDAL 240
 
Name Accession Description Interval E-value
CutC COG3142
Copper homeostasis protein CutC [Inorganic ion transport and metabolism];
26-270 6.25e-121

Copper homeostasis protein CutC [Inorganic ion transport and metabolism];


Pssm-ID: 442376  Cd Length: 240  Bit Score: 345.23  E-value: 6.25e-121
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 165932350  26 LMEVCVDSVESAVNAERGGAGRIELCSGLLEGGTTPSMGVLQVVKQSVQIPVFVMIRPRGGDFLYSDREVEVMKADIRLA 105
Cdd:COG3142    3 LLEVCVDSVEDALAAEAGGADRIELCSALAEGGLTPSYGLIKAAREAVDIPVHVMIRPRGGDFVYSDDEFEVMLRDIRAA 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 165932350 106 KLYGADGLVFGALTEDGHIDKELCLSLVALCRPLPVTFHRAFDMVHDPMAALETLLTLGFERVLTSGCDSSALEGLPLIK 185
Cdd:COG3142   83 RELGADGVVFGALTPDGEIDLERLKRLVEAAGGLPVTFHRAFDVVPDPLEALEQLIDLGVDRVLTSGGAATAEEGLDLLK 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 165932350 186 QLIDQAKGRIVVMPGGGITDKNLQRILEGSGATEFHCSARSSRDSGMkfRNSSVAMGaslahSEYSLKVTDVTKVRTLNA 265
Cdd:COG3142  163 ELVEQAGGRIEIMAGGGVRPENVPELVAATGVREVHLSARVRVPSSM--TNPGVSMG-----GEFSRSPTDAEKVRALRA 235

                 ....*
gi 165932350 266 IAKDV 270
Cdd:COG3142  236 ALDAL 240
CutC pfam03932
CutC family; Copper transport in Escherichia coli is mediated by the products of at least six ...
26-225 2.44e-89

CutC family; Copper transport in Escherichia coli is mediated by the products of at least six genes, cutA, cutB, cutC, cutD, cutE, and cutF. A mutation in one or more of these genes results in an increased copper sensitivity. Members of this family are between 200 and 300 amino acids in length are found in both eukaryotes and bacteria.


Pssm-ID: 427596  Cd Length: 201  Bit Score: 263.53  E-value: 2.44e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 165932350   26 LMEVCVDSVESAVNAERGGAGRIELCSGLLEGGTTPSMGVLQVVKQSVQIPVFVMIRPRGGDFLYSDREVEVMKADIRLA 105
Cdd:pfam03932   2 LLEVCIDNIESALAAQQGGADRVELCAALAVGGLTPSYGLLKSARQRSPIPVYVMIRPRGGDFCYSDGELAAMLEDIRTA 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 165932350  106 KLYGADGLVFGALTEDGHIDKELCLSLVALCRPLPVTFHRAFDMVHDPMAALETLLTLGFERVLTSGCDSSALEGLPLIK 185
Cdd:pfam03932  82 RELGAQGVVIGALDPDGEIDMKRMEKLIAAAGGLGVTFHRAFDVCADPEYALEQLIELGCERVLTSGGKSSALLGTDKIA 161
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 165932350  186 QLIDQAKGRIVVMPGGGITDKNLQRILEGSGATEFHCSAR 225
Cdd:pfam03932 162 ALVAQAAGRISIMAGAGVNAENVAELADRTGVNEVHGSAG 201
PRK11572 PRK11572
copper homeostasis protein CutC; Provisional
26-251 6.56e-80

copper homeostasis protein CutC; Provisional


Pssm-ID: 183208  Cd Length: 248  Bit Score: 241.45  E-value: 6.56e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 165932350  26 LMEVCVDSVESAVNAERGGAGRIELCSGLLEGGTTPSMGVLQVVKQSVQIPVFVMIRPRGGDFLYSDREVEVMKADIRLA 105
Cdd:PRK11572   3 LLEICCYSMECALTAQQAGADRIELCAAPKEGGLTPSLGVLKSVRERVTIPVHPIIRPRGGDFCYSDGEFAAMLEDIATV 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 165932350 106 KLYGADGLVFGALTEDGHIDKELCLSLVALCRPLPVTFHRAFDMVHDPMAALETLLTLGFERVLTSGCDSSALEGLPLIK 185
Cdd:PRK11572  83 RELGFPGLVTGVLDVDGHVDMPRMRKIMAAAGPLAVTFHRAFDMCANPLNALKQLADLGVARILTSGQQQDAEQGLSLIM 162
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 165932350 186 QLIDQAKGRIvVMPGGGITDKNLQRILEgSGATEFHCSARSSRDSGMKFRNSSVAMGASLAHSEYS 251
Cdd:PRK11572 163 ELIAASDGPI-IMAGAGVRLSNLHKFLD-AGVREVHSSAGQWVPSPMRYRKAGVSMSSDAEADEFS 226
 
Name Accession Description Interval E-value
CutC COG3142
Copper homeostasis protein CutC [Inorganic ion transport and metabolism];
26-270 6.25e-121

Copper homeostasis protein CutC [Inorganic ion transport and metabolism];


Pssm-ID: 442376  Cd Length: 240  Bit Score: 345.23  E-value: 6.25e-121
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 165932350  26 LMEVCVDSVESAVNAERGGAGRIELCSGLLEGGTTPSMGVLQVVKQSVQIPVFVMIRPRGGDFLYSDREVEVMKADIRLA 105
Cdd:COG3142    3 LLEVCVDSVEDALAAEAGGADRIELCSALAEGGLTPSYGLIKAAREAVDIPVHVMIRPRGGDFVYSDDEFEVMLRDIRAA 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 165932350 106 KLYGADGLVFGALTEDGHIDKELCLSLVALCRPLPVTFHRAFDMVHDPMAALETLLTLGFERVLTSGCDSSALEGLPLIK 185
Cdd:COG3142   83 RELGADGVVFGALTPDGEIDLERLKRLVEAAGGLPVTFHRAFDVVPDPLEALEQLIDLGVDRVLTSGGAATAEEGLDLLK 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 165932350 186 QLIDQAKGRIVVMPGGGITDKNLQRILEGSGATEFHCSARSSRDSGMkfRNSSVAMGaslahSEYSLKVTDVTKVRTLNA 265
Cdd:COG3142  163 ELVEQAGGRIEIMAGGGVRPENVPELVAATGVREVHLSARVRVPSSM--TNPGVSMG-----GEFSRSPTDAEKVRALRA 235

                 ....*
gi 165932350 266 IAKDV 270
Cdd:COG3142  236 ALDAL 240
CutC pfam03932
CutC family; Copper transport in Escherichia coli is mediated by the products of at least six ...
26-225 2.44e-89

CutC family; Copper transport in Escherichia coli is mediated by the products of at least six genes, cutA, cutB, cutC, cutD, cutE, and cutF. A mutation in one or more of these genes results in an increased copper sensitivity. Members of this family are between 200 and 300 amino acids in length are found in both eukaryotes and bacteria.


Pssm-ID: 427596  Cd Length: 201  Bit Score: 263.53  E-value: 2.44e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 165932350   26 LMEVCVDSVESAVNAERGGAGRIELCSGLLEGGTTPSMGVLQVVKQSVQIPVFVMIRPRGGDFLYSDREVEVMKADIRLA 105
Cdd:pfam03932   2 LLEVCIDNIESALAAQQGGADRVELCAALAVGGLTPSYGLLKSARQRSPIPVYVMIRPRGGDFCYSDGELAAMLEDIRTA 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 165932350  106 KLYGADGLVFGALTEDGHIDKELCLSLVALCRPLPVTFHRAFDMVHDPMAALETLLTLGFERVLTSGCDSSALEGLPLIK 185
Cdd:pfam03932  82 RELGAQGVVIGALDPDGEIDMKRMEKLIAAAGGLGVTFHRAFDVCADPEYALEQLIELGCERVLTSGGKSSALLGTDKIA 161
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 165932350  186 QLIDQAKGRIVVMPGGGITDKNLQRILEGSGATEFHCSAR 225
Cdd:pfam03932 162 ALVAQAAGRISIMAGAGVNAENVAELADRTGVNEVHGSAG 201
PRK11572 PRK11572
copper homeostasis protein CutC; Provisional
26-251 6.56e-80

copper homeostasis protein CutC; Provisional


Pssm-ID: 183208  Cd Length: 248  Bit Score: 241.45  E-value: 6.56e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 165932350  26 LMEVCVDSVESAVNAERGGAGRIELCSGLLEGGTTPSMGVLQVVKQSVQIPVFVMIRPRGGDFLYSDREVEVMKADIRLA 105
Cdd:PRK11572   3 LLEICCYSMECALTAQQAGADRIELCAAPKEGGLTPSLGVLKSVRERVTIPVHPIIRPRGGDFCYSDGEFAAMLEDIATV 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 165932350 106 KLYGADGLVFGALTEDGHIDKELCLSLVALCRPLPVTFHRAFDMVHDPMAALETLLTLGFERVLTSGCDSSALEGLPLIK 185
Cdd:PRK11572  83 RELGFPGLVTGVLDVDGHVDMPRMRKIMAAAGPLAVTFHRAFDMCANPLNALKQLADLGVARILTSGQQQDAEQGLSLIM 162
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 165932350 186 QLIDQAKGRIvVMPGGGITDKNLQRILEgSGATEFHCSARSSRDSGMKFRNSSVAMGASLAHSEYS 251
Cdd:PRK11572 163 ELIAASDGPI-IMAGAGVRLSNLHKFLD-AGVREVHSSAGQWVPSPMRYRKAGVSMSSDAEADEFS 226
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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