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Conserved domains on  [gi|157818773|ref|NP_001103049|]
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LRRN4 C-terminal-like protein precursor [Rattus norvegicus]

Protein Classification

fibronectin type III domain-containing protein( domain architecture ID 10045852)

fibronectin type III (FN3) domain-containing protein may be involved in specific interactions with other molecules through its FN3 domain

CATH:  2.60.40.10
Gene Ontology:  GO:0005515
PubMed:  19576999|9837732|8981327

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 83-162 7.74e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 49.03  E-value: 7.74e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818773  83 PEPPRLVEVQIVaEEGYAVAHWCAP---FSPVSHYWLLLWESN-GAPQKSASLNATVRRAEVKGLKPGVAYVLCVVAAND 158
Cdd:cd00063    1 PSPPTNLRVTDV-TSTSVTLSWTPPeddGGPITGYVVEYREKGsGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNG 79


                 ....
gi 157818773 159 AGKS 162
Cdd:cd00063   80 GGES 83
 
Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 83-162 7.74e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 49.03  E-value: 7.74e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818773  83 PEPPRLVEVQIVaEEGYAVAHWCAP---FSPVSHYWLLLWESN-GAPQKSASLNATVRRAEVKGLKPGVAYVLCVVAAND 158
Cdd:cd00063    1 PSPPTNLRVTDV-TSTSVTLSWTPPeddGGPITGYVVEYREKGsGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNG 79


                 ....
gi 157818773 159 AGKS 162
Cdd:cd00063   80 GGES 83
fn3 pfam00041
Fibronectin type III domain;
82-162 5.05e-07

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 46.25  E-value: 5.05e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818773   82 QPEPPRLVEVQivaeEGYAVAHWCAPF---SPVSHYWLLLWESN-GAPQKSASLNATVRRAEVKGLKPGVAYVLCVVAAN 157
Cdd:pfam00041   2 APSNLTVTDVT----STSLTVSWTPPPdgnGPITGYEVEYRPKNsGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVN 77


                  ....*
gi 157818773  158 DAGKS 162
Cdd:pfam00041  78 GGGEG 82
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 83-162 1.82e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 44.91  E-value: 1.82e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818773    83 PEPPRLVEVQIVaEEGYAVAHWCAPFSPVSH----YWLLLWESNGAPQKSASLNATVRRAEVKGLKPGVAYVLCVVAAND 158
Cdd:smart00060   1 PSPPSNLRVTDV-TSTSVTLSWEPPPDDGITgyivGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNG 79


                   ....
gi 157818773   159 AGKS 162
Cdd:smart00060  80 AGEG 83
 
Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 83-162 7.74e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 49.03  E-value: 7.74e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818773  83 PEPPRLVEVQIVaEEGYAVAHWCAP---FSPVSHYWLLLWESN-GAPQKSASLNATVRRAEVKGLKPGVAYVLCVVAAND 158
Cdd:cd00063    1 PSPPTNLRVTDV-TSTSVTLSWTPPeddGGPITGYVVEYREKGsGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNG 79


                 ....
gi 157818773 159 AGKS 162
Cdd:cd00063   80 GGES 83
fn3 pfam00041
Fibronectin type III domain;
82-162 5.05e-07

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 46.25  E-value: 5.05e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818773   82 QPEPPRLVEVQivaeEGYAVAHWCAPF---SPVSHYWLLLWESN-GAPQKSASLNATVRRAEVKGLKPGVAYVLCVVAAN 157
Cdd:pfam00041   2 APSNLTVTDVT----STSLTVSWTPPPdgnGPITGYEVEYRPKNsGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVN 77


                  ....*
gi 157818773  158 DAGKS 162
Cdd:pfam00041  78 GGGEG 82
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 83-162 1.82e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 44.91  E-value: 1.82e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818773    83 PEPPRLVEVQIVaEEGYAVAHWCAPFSPVSH----YWLLLWESNGAPQKSASLNATVRRAEVKGLKPGVAYVLCVVAAND 158
Cdd:smart00060   1 PSPPSNLRVTDV-TSTSVTLSWEPPPDDGITgyivGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNG 79


                   ....
gi 157818773   159 AGKS 162
Cdd:smart00060  80 AGEG 83
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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