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Conserved domains on  [gi|357588473|ref|NP_001101544|]
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fizzy-related protein homolog [Rattus norvegicus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
200-472 2.70e-52

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 182.03  E-value: 2.70e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588473 200 VLSVGLGTCVYLWSACTSQVTRLcdLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSVLEGHTARVGALAW 279
Cdd:COG2319   93 LASASADGTVRLWDLATGLLLRT--LTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAF 170

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588473 280 NAD--QLSSGSRDRMILQRDIRTPALQseRRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAA 357
Cdd:COG2319  171 SPDgkLLASGSDDGTVRLWDLATGKLL--RTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGS 248

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588473 358 VKAIAWSPHQHgLLASGGgtADRCIRFWNTLTGQPLQCIDT-GSQVCNLAWSKHANELVSthGYSQNQILVWKYPSLTQV 436
Cdd:COG2319  249 VRSVAFSPDGR-LLASGS--ADGTVRLWDLATGELLRTLTGhSGGVNSVAFSPDGKLLAS--GSDDGTVRLWDLATGKLL 323

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 357588473 437 AKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNV 472
Cdd:COG2319  324 RTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDL 359
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
200-472 2.70e-52

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 182.03  E-value: 2.70e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588473 200 VLSVGLGTCVYLWSACTSQVTRLcdLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSVLEGHTARVGALAW 279
Cdd:COG2319   93 LASASADGTVRLWDLATGLLLRT--LTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAF 170

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588473 280 NAD--QLSSGSRDRMILQRDIRTPALQseRRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAA 357
Cdd:COG2319  171 SPDgkLLASGSDDGTVRLWDLATGKLL--RTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGS 248

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588473 358 VKAIAWSPHQHgLLASGGgtADRCIRFWNTLTGQPLQCIDT-GSQVCNLAWSKHANELVSthGYSQNQILVWKYPSLTQV 436
Cdd:COG2319  249 VRSVAFSPDGR-LLASGS--ADGTVRLWDLATGELLRTLTGhSGGVNSVAFSPDGKLLAS--GSDDGTVRLWDLATGKLL 323

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 357588473 437 AKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNV 472
Cdd:COG2319  324 RTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDL 359
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 193-471 4.80e-42

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 151.33  E-value: 4.80e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588473 193 VDWSSLN--VLSVGLGTCVYLWSACTSQVtrLCDLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSVLEGH 270
Cdd:cd00200   15 VAFSPDGklLATGSGDGTIKVWDLETGEL--LRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGH 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588473 271 TARVGALAWNADQ--LSSGSRDRMILQRDIRTPalQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPV 348
Cdd:cd00200   93 TSYVSSVAFSPDGriLSSSSRDKTIKVWDVETG--KCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCV 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588473 349 QQYTEHLAAVKAIAWSPHQHGLLASGGgtaDRCIRFWNTLTGQPLQCIDT-GSQVCNLAWSKHANELVSthGYSQNQILV 427
Cdd:cd00200  171 ATLTGHTGEVNSVAFSPDGEKLLSSSS---DGTIKLWDLSTGKCLGTLRGhENGVNSVAFSPDGYLLAS--GSEDGTIRV 245

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 357588473 428 WKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWN 471
Cdd:cd00200  246 WDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 304-341 1.86e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.61  E-value: 1.86e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 357588473   304 QSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWN 341
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 296-482 1.98e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 50.47  E-value: 1.98e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588473 296 RDIRTPALQserrLQGhRQEVCGLKW-STDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASg 374
Cdd:PLN00181 520 RDIHYPVVE----LAS-RSKLSGICWnSYIKSQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLAS- 593

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588473 375 gGTADRCIRFWNTLTGQPLQCIDTGSQVCNLAWSKHANELVStHGYSQNQILVW--KYPSLTqVAKLTGHSYRVLYLAMS 452
Cdd:PLN00181 594 -GSDDGSVKLWSINQGVSIGTIKTKANICCVQFPSESGRSLA-FGSADHKVYYYdlRNPKLP-LCTMIGHSKTVSYVRFV 670

                        170       180       190
                 ....*....|....*....|....*....|
gi 357588473 453 pDGEAIVTGAGDETLRFWNVFSKTRSTKES 482
Cdd:PLN00181 671 -DSSTLVSSSTDNTLKLWDLSMSISGINET 699
WD40 pfam00400
WD domain, G-beta repeat;
304-341 1.46e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.95  E-value: 1.46e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 357588473  304 QSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWN 341
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
200-472 2.70e-52

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 182.03  E-value: 2.70e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588473 200 VLSVGLGTCVYLWSACTSQVTRLcdLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSVLEGHTARVGALAW 279
Cdd:COG2319   93 LASASADGTVRLWDLATGLLLRT--LTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAF 170

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588473 280 NAD--QLSSGSRDRMILQRDIRTPALQseRRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAA 357
Cdd:COG2319  171 SPDgkLLASGSDDGTVRLWDLATGKLL--RTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGS 248

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588473 358 VKAIAWSPHQHgLLASGGgtADRCIRFWNTLTGQPLQCIDT-GSQVCNLAWSKHANELVSthGYSQNQILVWKYPSLTQV 436
Cdd:COG2319  249 VRSVAFSPDGR-LLASGS--ADGTVRLWDLATGELLRTLTGhSGGVNSVAFSPDGKLLAS--GSDDGTVRLWDLATGKLL 323

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 357588473 437 AKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNV 472
Cdd:COG2319  324 RTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDL 359
WD40 COG2319
WD40 repeat [General function prediction only];
209-472 2.31e-48

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 171.63  E-value: 2.31e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588473 209 VYLWSACTSQVTRlcDLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSVLEGHTARVGALAWNAD--QLSS 286
Cdd:COG2319  144 VRLWDLATGKLLR--TLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDgkLLAS 221

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588473 287 GSRDRMILQRDIRTPALQseRRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPH 366
Cdd:COG2319  222 GSADGTVRLWDLATGKLL--RTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPD 299

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588473 367 QHgLLASGGgtADRCIRFWNTLTGQPLQCID-TGSQVCNLAWSKHANELVSthGYSQNQILVWKYPSLTQVAKLTGHSYR 445
Cdd:COG2319  300 GK-LLASGS--DDGTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKTLAS--GSDDGTVRLWDLATGELLRTLTGHTGA 374

                        250       260
                 ....*....|....*....|....*..
gi 357588473 446 VLYLAMSPDGEAIVTGAGDETLRFWNV 472
Cdd:COG2319  375 VTSVAFSPDGRTLASGSADGTVRLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
225-472 2.28e-44

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 160.85  E-value: 2.28e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588473 225 LSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSVLEGHTARVGALAWNAD--QLSSGSRDRMILQRDIRTPA 302
Cdd:COG2319   74 LLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDgkTLASGSADGTVRLWDLATGK 153

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588473 303 LQseRRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHgLLASGGgtADRCI 382
Cdd:COG2319  154 LL--RTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGK-LLASGS--ADGTV 228

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588473 383 RFWNTLTGQPLQCIDT-GSQVCNLAWSKHANELVSthGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTG 461
Cdd:COG2319  229 RLWDLATGKLLRTLTGhSGSVRSVAFSPDGRLLAS--GSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASG 306

                        250
                 ....*....|.
gi 357588473 462 AGDETLRFWNV 472
Cdd:COG2319  307 SDDGTVRLWDL 317
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 193-471 4.80e-42

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 151.33  E-value: 4.80e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588473 193 VDWSSLN--VLSVGLGTCVYLWSACTSQVtrLCDLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSVLEGH 270
Cdd:cd00200   15 VAFSPDGklLATGSGDGTIKVWDLETGEL--LRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGH 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588473 271 TARVGALAWNADQ--LSSGSRDRMILQRDIRTPalQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPV 348
Cdd:cd00200   93 TSYVSSVAFSPDGriLSSSSRDKTIKVWDVETG--KCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCV 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588473 349 QQYTEHLAAVKAIAWSPHQHGLLASGGgtaDRCIRFWNTLTGQPLQCIDT-GSQVCNLAWSKHANELVSthGYSQNQILV 427
Cdd:cd00200  171 ATLTGHTGEVNSVAFSPDGEKLLSSSS---DGTIKLWDLSTGKCLGTLRGhENGVNSVAFSPDGYLLAS--GSEDGTIRV 245

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 357588473 428 WKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWN 471
Cdd:cd00200  246 WDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 230-472 1.72e-38

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 141.70  E-value: 1.72e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588473 230 DSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSVLEGHTARVGALAWNAD--QLSSGSRDRMILQRDIRTPALQseR 307
Cdd:cd00200   10 GGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADgtYLASGSSDKTIRLWDLETGECV--R 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588473 308 RLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHgLLASGGgtADRCIRFWNT 387
Cdd:cd00200   88 TLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGT-FVASSS--QDGTIKLWDL 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588473 388 LTGQPLQCIdTG--SQVCNLAWSKHANELVSthGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDE 465
Cdd:cd00200  165 RTGKCVATL-TGhtGEVNSVAFSPDGEKLLS--SSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDG 241


                 ....*..
gi 357588473 466 TLRFWNV 472
Cdd:cd00200  242 TIRVWDL 248
WD40 COG2319
WD40 repeat [General function prediction only];
211-472 1.40e-35

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 136.58  E-value: 1.40e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588473 211 LWSACTSQVTRLCDLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSVLEGHTARVGALAWNAD--QLSSGS 288
Cdd:COG2319   18 LALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDgrLLASAS 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588473 289 RDRMILQRDIRTPALQseRRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQH 368
Cdd:COG2319   98 ADGTVRLWDLATGLLL--RTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGK 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588473 369 gLLASGGgtADRCIRFWNTLTGQPLQCID-TGSQVCNLAWSKHANELVSthGYSQNQILVWKYPSLTQVAKLTGHSYRVL 447
Cdd:COG2319  176 -LLASGS--DDGTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKLLAS--GSADGTVRLWDLATGKLLRTLTGHSGSVR 250

                        250       260
                 ....*....|....*....|....*
gi 357588473 448 YLAMSPDGEAIVTGAGDETLRFWNV 472
Cdd:COG2319  251 SVAFSPDGRLLASGSADGTVRLWDL 275
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 266-472 1.37e-34

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 131.30  E-value: 1.37e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588473 266 VLEGHTARVGALAWNADQ--LSSGSRDRMILQRDIRTPALqsERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHS 343
Cdd:cd00200    4 TLKGHTGGVTCVAFSPDGklLATGSGDGTIKVWDLETGEL--LRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588473 344 SLSPVQQYTEHLAAVKAIAWSPHQHgLLASGGgtADRCIRFWNTLTGQPLQCIDT-GSQVCNLAWSkHANELVSThGYSQ 422
Cdd:cd00200   82 TGECVRTLTGHTSYVSSVAFSPDGR-ILSSSS--RDKTIKVWDVETGKCLTTLRGhTDWVNSVAFS-PDGTFVAS-SSQD 156

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 357588473 423 NQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNV 472
Cdd:cd00200  157 GTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDL 206
WD40 COG2319
WD40 repeat [General function prediction only];
200-387 5.75e-30

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 121.17  E-value: 5.75e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588473 200 VLSVGLGTCVYLWSActSQVTRLCDLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSVLEGHTARVGALAW 279
Cdd:COG2319  219 LASGSADGTVRLWDL--ATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAF 296

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588473 280 NAD--QLSSGSRDRMILQRDIRTPALQseRRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAA 357
Cdd:COG2319  297 SPDgkLLASGSDDGTVRLWDLATGKLL--RTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGA 374

                        170       180       190
                 ....*....|....*....|....*....|
gi 357588473 358 VKAIAWSPHQHgLLASGGgtADRCIRFWNT 387
Cdd:COG2319  375 VTSVAFSPDGR-TLASGS--ADGTVRLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
236-472 8.91e-30

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 120.40  E-value: 8.91e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588473 236 GWSERGNLVAVGTHKGFVQIWDAAAGKKLSVLEGHTARVGALAWNADQLSSGSRDRMILQRDIRTPALQSERRLQGHRQE 315
Cdd:COG2319    1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588473 316 VCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHgLLASGGgtADRCIRFWNTLTGQPLQC 395
Cdd:COG2319   81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGK-TLASGS--ADGTVRLWDLATGKLLRT 157

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 357588473 396 IDTGSQ-VCNLAWSKHANELVSthGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNV 472
Cdd:COG2319  158 LTGHSGaVTSVAFSPDGKLLAS--GSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDL 233
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 305-472 1.87e-25

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 105.88  E-value: 1.87e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588473 305 SERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASGGgtaDRCIRF 384
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSS---DKTIRL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588473 385 WNTLTGQPLQCIdTG--SQVCNLAWSKHaNELVSThGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGA 462
Cdd:cd00200   78 WDLETGECVRTL-TGhtSYVSSVAFSPD-GRILSS-SSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSS 154

                        170
                 ....*....|
gi 357588473 463 GDETLRFWNV 472
Cdd:cd00200  155 QDGTIKLWDL 164
WD40 COG2319
WD40 repeat [General function prediction only];
322-474 5.38e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 61.08  E-value: 5.38e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588473 322 STDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRciRFWNTLTGQPLQCIDTGSQ 401
Cdd:COG2319    3 SADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLL--LLDAAAGALLATLLGHTAA 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 357588473 402 VCNLAWSKHANELVSthGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNVFS 474
Cdd:COG2319   81 VLSVAFSPDGRLLAS--ASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLAT 151
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 304-341 1.86e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.61  E-value: 1.86e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 357588473   304 QSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWN 341
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 296-482 1.98e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 50.47  E-value: 1.98e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588473 296 RDIRTPALQserrLQGhRQEVCGLKW-STDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASg 374
Cdd:PLN00181 520 RDIHYPVVE----LAS-RSKLSGICWnSYIKSQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLAS- 593

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588473 375 gGTADRCIRFWNTLTGQPLQCIDTGSQVCNLAWSKHANELVStHGYSQNQILVW--KYPSLTqVAKLTGHSYRVLYLAMS 452
Cdd:PLN00181 594 -GSDDGSVKLWSINQGVSIGTIKTKANICCVQFPSESGRSLA-FGSADHKVYYYdlRNPKLP-LCTMIGHSKTVSYVRFV 670

                        170       180       190
                 ....*....|....*....|....*....|
gi 357588473 453 pDGEAIVTGAGDETLRFWNVFSKTRSTKES 482
Cdd:PLN00181 671 -DSSTLVSSSTDNTLKLWDLSMSISGINET 699
WD40 pfam00400
WD domain, G-beta repeat;
304-341 1.46e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.95  E-value: 1.46e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 357588473  304 QSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWN 341
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 432-471 3.44e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.76  E-value: 3.44e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 357588473   432 SLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWN 471
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
434-471 9.89e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.64  E-value: 9.89e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 357588473  434 TQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWN 471
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 344-386 2.32e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.45  E-value: 2.32e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 357588473   344 SLSPVQQYTEHLAAVKAIAWSPHQHgLLASGGgtADRCIRFWN 386
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGK-YLASGS--DDGTIKLWD 40
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 228-280 7.38e-04

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 38.80  E-value: 7.38e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 357588473  228 EGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSVLEGHTARVGALAWN 280
Cdd:pfam12894  37 EDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLITCLGWG 89
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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