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Conserved domains on  [gi|157818989|ref|NP_001101171|]
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leucine-rich repeat-containing protein 71 [Rattus norvegicus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1006001)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
RNA1 super family cl34950
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 138-304 4.12e-18

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


The actual alignment was detected with superfamily member COG5238:

Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 86.77  E-value: 4.12e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818989 138 KTVKEIYIRGWKIEERILGIFSKCLPPLSQLQAINLWKVGLTEKTLTAFIALLPLcSPTLRKVSLEGNPIPEQ---SFNK 214
Cdd:COG5238  180 NSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKG-NKSLTTLDLSNNQIGDEgviALAE 258

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818989 215 LMGLDSTIVHLSLRNNNINDHGAQLLGQALSTlhssNRTLVSLNLAFNHIGDEGAGYIADGLRLNRSLLWLSLAHNHIQD 294
Cdd:COG5238  259 ALKNNTTVETLYLSGNQIGAEGAIALAKALQG----NTTLTSLDLSVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGA 334

                        170
                 ....*....|
gi 157818989 295 KGALKLAEVL 304
Cdd:COG5238  335 QGAIALAKAL 344
 
Name Accession Description Interval E-value
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 138-304 4.12e-18

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 86.77  E-value: 4.12e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818989 138 KTVKEIYIRGWKIEERILGIFSKCLPPLSQLQAINLWKVGLTEKTLTAFIALLPLcSPTLRKVSLEGNPIPEQ---SFNK 214
Cdd:COG5238  180 NSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKG-NKSLTTLDLSNNQIGDEgviALAE 258

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818989 215 LMGLDSTIVHLSLRNNNINDHGAQLLGQALSTlhssNRTLVSLNLAFNHIGDEGAGYIADGLRLNRSLLWLSLAHNHIQD 294
Cdd:COG5238  259 ALKNNTTVETLYLSGNQIGAEGAIALAKALQG----NTTLTSLDLSVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGA 334

                        170
                 ....*....|
gi 157818989 295 KGALKLAEVL 304
Cdd:COG5238  335 QGAIALAKAL 344
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 137-308 1.58e-15

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 77.78  E-value: 1.58e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818989 137 SKTVKEIYIRGWKIEERILGIFSKCLPPLS-QLQAINLWKVGLTEKTLTAFIALLPLcSPTLRKVSLEGNPIPEQSFNKL 215
Cdd:cd00116  107 SSSLQELKLNNNGLGDRGLRLLAKGLKDLPpALEKLVLGRNRLEGASCEALAKALRA-NRDLKELNLANNGIGDAGIRAL 185

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818989 216 ---MGLDSTIVHLSLRNNNINDHGAQLLGQALSTlhssNRTLVSLNLAFNHIGDEGAGYIADGLR-LNRSLLWLSLAHNH 291
Cdd:cd00116  186 aegLKANCNLEVLDLNNNGLTDEGASALAETLAS----LKSLEVLNLGDNNLTDAGAAALASALLsPNISLLTLSLSCND 261

                        170
                 ....*....|....*..
gi 157818989 292 IQDKGALKLAEVLRPFE 308
Cdd:cd00116  262 ITDDGAKDLAEVLAEKE 278
LRR_6 pfam13516
Leucine Rich repeat;
250-273 1.12e-04

Leucine Rich repeat;


Pssm-ID: 463907 [Multi-domain]  Cd Length: 24  Bit Score: 39.14  E-value: 1.12e-04
                          10        20
                  ....*....|....*....|....
gi 157818989  250 SNRTLVSLNLAFNHIGDEGAGYIA 273
Cdd:pfam13516   1 SNTHLTTLDLSDNDIGDEGAEALA 24
LRR_RI smart00368
Leucine rich repeat, ribonuclease inhibitor type;
279-305 2.74e-04

Leucine rich repeat, ribonuclease inhibitor type;


Pssm-ID: 197686 [Multi-domain]  Cd Length: 28  Bit Score: 38.16  E-value: 2.74e-04
                           10        20
                   ....*....|....*....|....*..
gi 157818989   279 NRSLLWLSLAHNHIQDKGALKLAEVLR 305
Cdd:smart00368   1 NPSLRELDLSNNKLGDEGARALAEALK 27
 
Name Accession Description Interval E-value
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 138-304 4.12e-18

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 86.77  E-value: 4.12e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818989 138 KTVKEIYIRGWKIEERILGIFSKCLPPLSQLQAINLWKVGLTEKTLTAFIALLPLcSPTLRKVSLEGNPIPEQ---SFNK 214
Cdd:COG5238  180 NSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKG-NKSLTTLDLSNNQIGDEgviALAE 258

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818989 215 LMGLDSTIVHLSLRNNNINDHGAQLLGQALSTlhssNRTLVSLNLAFNHIGDEGAGYIADGLRLNRSLLWLSLAHNHIQD 294
Cdd:COG5238  259 ALKNNTTVETLYLSGNQIGAEGAIALAKALQG----NTTLTSLDLSVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGA 334

                        170
                 ....*....|
gi 157818989 295 KGALKLAEVL 304
Cdd:COG5238  335 QGAIALAKAL 344
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 137-308 1.58e-15

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 77.78  E-value: 1.58e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818989 137 SKTVKEIYIRGWKIEERILGIFSKCLPPLS-QLQAINLWKVGLTEKTLTAFIALLPLcSPTLRKVSLEGNPIPEQSFNKL 215
Cdd:cd00116  107 SSSLQELKLNNNGLGDRGLRLLAKGLKDLPpALEKLVLGRNRLEGASCEALAKALRA-NRDLKELNLANNGIGDAGIRAL 185

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818989 216 ---MGLDSTIVHLSLRNNNINDHGAQLLGQALSTlhssNRTLVSLNLAFNHIGDEGAGYIADGLR-LNRSLLWLSLAHNH 291
Cdd:cd00116  186 aegLKANCNLEVLDLNNNGLTDEGASALAETLAS----LKSLEVLNLGDNNLTDAGAAALASALLsPNISLLTLSLSCND 261

                        170
                 ....*....|....*..
gi 157818989 292 IQDKGALKLAEVLRPFE 308
Cdd:cd00116  262 ITDDGAKDLAEVLAEKE 278
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 194-305 6.16e-15

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 77.14  E-value: 6.16e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818989 194 SPTLRKVSLEGNPIPEQS---FNKLMGLDSTIVHLSLRNNNINDHGAQLLGQALStlhsSNRTLVSLNLAFNHIGDEGAG 270
Cdd:COG5238  207 NTTVTTLWLKRNPIGDEGaeiLAEALKGNKSLTTLDLSNNQIGDEGVIALAEALK----NNTTVETLYLSGNQIGAEGAI 282

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 157818989 271 YIADGLRLNRSLLWLSLAHNHIQDKGALKLAEVLR 305
Cdd:COG5238  283 ALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQ 317
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 195-304 8.62e-14

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 73.67  E-value: 8.62e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818989 195 PTLRKVSLEGNPIPEQS---FNKLMGLDSTIVHLSLRNNNINDHGAQLLGQALSTlhssNRTLVSLNLAFNHIGDEGAGY 271
Cdd:COG5238  292 TTLTSLDLSVNRIGDEGaiaLAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQE----NTTLHSLDLSDNQIGDEGAIA 367

                         90       100       110
                 ....*....|....*....|....*....|...
gi 157818989 272 IADGLRLNRSLLWLSLAHNHIQDKGALKLAEVL 304
Cdd:COG5238  368 LAKYLEGNTTLRELNLGKNNIGKQGAEALIDAL 400
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 135-304 1.20e-11

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 66.74  E-value: 1.20e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818989 135 EDSKTVKEIYIRGWKIEERILGIFSKCLPPLSQLQAINLWKVGLTEKTLTAFIALLPLcSPTLRKVSLEGNPIPEQSFNK 214
Cdd:COG5238  261 KNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQG-NKTLHTLNLAYNGIGAQGAIA 339

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818989 215 L---MGLDSTIVHLSLRNNNINDHGAQLLGQALStlhsSNRTLVSLNLAFNHIGDEGAGYIADGLRLNRsLLWLSLAHNH 291
Cdd:COG5238  340 LakaLQENTTLHSLDLSDNQIGDEGAIALAKYLE----GNTTLRELNLGKNNIGKQGAEALIDALQTNR-LHTLILDGNL 414

                        170
                 ....*....|...
gi 157818989 292 IQDKGALKLAEVL 304
Cdd:COG5238  415 IGAEAQQRLEQLL 427
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 195-305 1.89e-10

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 62.89  E-value: 1.89e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818989 195 PTLRKVSLEGNPIPEQS----FNKLMGLDSTIVHLSLRNNNINDHGAQLLGQALStlhsSNRTLVSLNLAFNHIGDEGAG 270
Cdd:COG5238  151 LGGNAVHLLGLAARLGLlaaiSMAKALQNNSVETVYLGCNQIGDEGIEELAEALT----QNTTVTTLWLKRNPIGDEGAE 226

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 157818989 271 YIADGLRLNRSLLWLSLAHNHIQDKGALKLAEVLR 305
Cdd:COG5238  227 ILAEALKGNKSLTTLDLSNNQIGDEGVIALAEALK 261
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 152-305 2.28e-09

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 58.91  E-value: 2.28e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818989 152 ERILGIFSKCLPPLSQLQAINLWKVGLTEKTLTAFIALLPlcSPTLRKVSLEGNPIPEQSFNKLM-GLDSTIVHLS---L 227
Cdd:cd00116   67 PRGLQSLLQGLTKGCGLQELDLSDNALGPDGCGVLESLLR--SSSLQELKLNNNGLGDRGLRLLAkGLKDLPPALEklvL 144

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 157818989 228 RNNNINDHGAQLLGQALStlhsSNRTLVSLNLAFNHIGDEGAGYIADGLRLNRSLLWLSLAHNHIQDKGALKLAEVLR 305
Cdd:cd00116  145 GRNRLEGASCEALAKALR----ANRDLKELNLANNGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDEGASALAETLA 218
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 162-307 5.74e-07

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 51.59  E-value: 5.74e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818989 162 LPPLSQLQAINLWKVGLTE-------KTLTAFIALLPLC----------------------SPTLRKVSLEGNPI-PEQS 211
Cdd:cd00116   19 LPKLLCLQVLRLEGNTLGEeaakalaSALRPQPSLKELClslnetgriprglqsllqgltkGCGLQELDLSDNALgPDGC 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818989 212 -FNKLMGLDSTIVHLSLRNNNINDHGAQLLGQALSTLHSSnrtLVSLNLAFNHIGDEGAGYIADGLRLNRSLLWLSLAHN 290
Cdd:cd00116   99 gVLESLLRSSSLQELKLNNNGLGDRGLRLLAKGLKDLPPA---LEKLVLGRNRLEGASCEALAKALRANRDLKELNLANN 175

                        170
                 ....*....|....*..
gi 157818989 291 HIQDKGALKLAEVLRPF 307
Cdd:cd00116  176 GIGDAGIRALAEGLKAN 192
LRR_6 pfam13516
Leucine Rich repeat;
250-273 1.12e-04

Leucine Rich repeat;


Pssm-ID: 463907 [Multi-domain]  Cd Length: 24  Bit Score: 39.14  E-value: 1.12e-04
                          10        20
                  ....*....|....*....|....
gi 157818989  250 SNRTLVSLNLAFNHIGDEGAGYIA 273
Cdd:pfam13516   1 SNTHLTTLDLSDNDIGDEGAEALA 24
LRR_RI smart00368
Leucine rich repeat, ribonuclease inhibitor type;
279-305 2.74e-04

Leucine rich repeat, ribonuclease inhibitor type;


Pssm-ID: 197686 [Multi-domain]  Cd Length: 28  Bit Score: 38.16  E-value: 2.74e-04
                           10        20
                   ....*....|....*....|....*..
gi 157818989   279 NRSLLWLSLAHNHIQDKGALKLAEVLR 305
Cdd:smart00368   1 NPSLRELDLSNNKLGDEGARALAEALK 27
LRR_RI smart00368
Leucine rich repeat, ribonuclease inhibitor type;
251-277 3.59e-03

Leucine rich repeat, ribonuclease inhibitor type;


Pssm-ID: 197686 [Multi-domain]  Cd Length: 28  Bit Score: 35.08  E-value: 3.59e-03
                           10        20
                   ....*....|....*....|....*..
gi 157818989   251 NRTLVSLNLAFNHIGDEGAGYIADGLR 277
Cdd:smart00368   1 NPSLRELDLSNNKLGDEGARALAEALK 27
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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