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Conserved domains on  [gi|157818657|ref|NP_001101156|]
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small proline-rich protein 3 [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cornifin super family cl25524
Cornifin (SPRR) family; SPRR genes (formerly SPR) encode a novel class of polypeptides (small ...
 17-136 5.26e-19

Cornifin (SPRR) family; SPRR genes (formerly SPR) encode a novel class of polypeptides (small proline rich proteins) that are strongly induced during differentiation of human epidermal keratinocytes in vitro and in vivo. The most characteriztic feature of the SPRR gene family resides in the structure of the central segments of the encoded polypeptides that are built up from tandemly repeated units of either eight (SPRR1 and SPRR3) or nine (SPRR2) amino acids with the general consensus XKXPEPXX where X is any amino acid. In order to avoid bacterial contamination due to the high polar-nature of the HMM the threshold has been set very high.


The actual alignment was detected with superfamily member pfam02389:

Pssm-ID: 280537 [Multi-domain]  Cd Length: 135  Bit Score: 80.48  E-value: 5.26e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818657   17 QQHQVKQPCQPPPQGKFVPiATSEPCHTGVPQPGNTKIPEPCSTKVPEPGYTVVLEPDYTTVPGSCSTNVTKPDYTTIPG 96
Cdd:pfam02389   1 HQQQVKQPCQPPPQEPCVP-TTKEPCHSKVPEPCNPKVPEPCCPKVPEPCCPKVPEPCCPKVPEPCCPKVPEPCYPKVPE 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 157818657   97 PCSTNIPGPDNV-VPESCSTNITEPNYTTIPGPCSTNIPGP 136
Cdd:pfam02389  80 PCSPKVPEPCHPkAPEPCHPKVPEPCYPKAPEPCQPKVPEP 120
Cornifin super family cl25524
Cornifin (SPRR) family; SPRR genes (formerly SPR) encode a novel class of polypeptides (small ...
 137-250 1.42e-14

Cornifin (SPRR) family; SPRR genes (formerly SPR) encode a novel class of polypeptides (small proline rich proteins) that are strongly induced during differentiation of human epidermal keratinocytes in vitro and in vivo. The most characteriztic feature of the SPRR gene family resides in the structure of the central segments of the encoded polypeptides that are built up from tandemly repeated units of either eight (SPRR1 and SPRR3) or nine (SPRR2) amino acids with the general consensus XKXPEPXX where X is any amino acid. In order to avoid bacterial contamination due to the high polar-nature of the HMM the threshold has been set very high.


The actual alignment was detected with superfamily member pfam02389:

Pssm-ID: 280537 [Multi-domain]  Cd Length: 135  Bit Score: 68.54  E-value: 1.42e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818657  137 DTMVPGSCSTSTTEPNYTTIHGPCTTNIPDPGCAMVPGPCSTNISEPssepCSTNVREPGYLNASEPTNAKVPDQGYTKI 216
Cdd:pfam02389  26 HSKVPEPCNPKVPEPCCPKVPEPCCPKVPEPCCPKVPEPCCPKVPEP----CYPKVPEPCSPKVPEPCHPKAPEPCHPKV 101

                          90       100       110
                  ....*....|....*....|....*....|....
gi 157818657  217 PDQGYSKVPEPCQSRTPEVCPTTVTPGLAQQKTK 250
Cdd:pfam02389 102 PEPCYPKAPEPCQPKVPEPCPSTVTPGPAQQKTK 135
 
Name Accession Description Interval E-value
Cornifin pfam02389
Cornifin (SPRR) family; SPRR genes (formerly SPR) encode a novel class of polypeptides (small ...
 17-136 5.26e-19

Cornifin (SPRR) family; SPRR genes (formerly SPR) encode a novel class of polypeptides (small proline rich proteins) that are strongly induced during differentiation of human epidermal keratinocytes in vitro and in vivo. The most characteriztic feature of the SPRR gene family resides in the structure of the central segments of the encoded polypeptides that are built up from tandemly repeated units of either eight (SPRR1 and SPRR3) or nine (SPRR2) amino acids with the general consensus XKXPEPXX where X is any amino acid. In order to avoid bacterial contamination due to the high polar-nature of the HMM the threshold has been set very high.


Pssm-ID: 280537 [Multi-domain]  Cd Length: 135  Bit Score: 80.48  E-value: 5.26e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818657   17 QQHQVKQPCQPPPQGKFVPiATSEPCHTGVPQPGNTKIPEPCSTKVPEPGYTVVLEPDYTTVPGSCSTNVTKPDYTTIPG 96
Cdd:pfam02389   1 HQQQVKQPCQPPPQEPCVP-TTKEPCHSKVPEPCNPKVPEPCCPKVPEPCCPKVPEPCCPKVPEPCCPKVPEPCYPKVPE 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 157818657   97 PCSTNIPGPDNV-VPESCSTNITEPNYTTIPGPCSTNIPGP 136
Cdd:pfam02389  80 PCSPKVPEPCHPkAPEPCHPKVPEPCYPKAPEPCQPKVPEP 120
Cornifin pfam02389
Cornifin (SPRR) family; SPRR genes (formerly SPR) encode a novel class of polypeptides (small ...
 137-250 1.42e-14

Cornifin (SPRR) family; SPRR genes (formerly SPR) encode a novel class of polypeptides (small proline rich proteins) that are strongly induced during differentiation of human epidermal keratinocytes in vitro and in vivo. The most characteriztic feature of the SPRR gene family resides in the structure of the central segments of the encoded polypeptides that are built up from tandemly repeated units of either eight (SPRR1 and SPRR3) or nine (SPRR2) amino acids with the general consensus XKXPEPXX where X is any amino acid. In order to avoid bacterial contamination due to the high polar-nature of the HMM the threshold has been set very high.


Pssm-ID: 280537 [Multi-domain]  Cd Length: 135  Bit Score: 68.54  E-value: 1.42e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818657  137 DTMVPGSCSTSTTEPNYTTIHGPCTTNIPDPGCAMVPGPCSTNISEPssepCSTNVREPGYLNASEPTNAKVPDQGYTKI 216
Cdd:pfam02389  26 HSKVPEPCNPKVPEPCCPKVPEPCCPKVPEPCCPKVPEPCCPKVPEP----CYPKVPEPCSPKVPEPCHPKAPEPCHPKV 101

                          90       100       110
                  ....*....|....*....|....*....|....
gi 157818657  217 PDQGYSKVPEPCQSRTPEVCPTTVTPGLAQQKTK 250
Cdd:pfam02389 102 PEPCYPKAPEPCQPKVPEPCPSTVTPGPAQQKTK 135
 
Name Accession Description Interval E-value
Cornifin pfam02389
Cornifin (SPRR) family; SPRR genes (formerly SPR) encode a novel class of polypeptides (small ...
 17-136 5.26e-19

Cornifin (SPRR) family; SPRR genes (formerly SPR) encode a novel class of polypeptides (small proline rich proteins) that are strongly induced during differentiation of human epidermal keratinocytes in vitro and in vivo. The most characteriztic feature of the SPRR gene family resides in the structure of the central segments of the encoded polypeptides that are built up from tandemly repeated units of either eight (SPRR1 and SPRR3) or nine (SPRR2) amino acids with the general consensus XKXPEPXX where X is any amino acid. In order to avoid bacterial contamination due to the high polar-nature of the HMM the threshold has been set very high.


Pssm-ID: 280537 [Multi-domain]  Cd Length: 135  Bit Score: 80.48  E-value: 5.26e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818657   17 QQHQVKQPCQPPPQGKFVPiATSEPCHTGVPQPGNTKIPEPCSTKVPEPGYTVVLEPDYTTVPGSCSTNVTKPDYTTIPG 96
Cdd:pfam02389   1 HQQQVKQPCQPPPQEPCVP-TTKEPCHSKVPEPCNPKVPEPCCPKVPEPCCPKVPEPCCPKVPEPCCPKVPEPCYPKVPE 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 157818657   97 PCSTNIPGPDNV-VPESCSTNITEPNYTTIPGPCSTNIPGP 136
Cdd:pfam02389  80 PCSPKVPEPCHPkAPEPCHPKVPEPCYPKAPEPCQPKVPEP 120
Cornifin pfam02389
Cornifin (SPRR) family; SPRR genes (formerly SPR) encode a novel class of polypeptides (small ...
 137-250 1.42e-14

Cornifin (SPRR) family; SPRR genes (formerly SPR) encode a novel class of polypeptides (small proline rich proteins) that are strongly induced during differentiation of human epidermal keratinocytes in vitro and in vivo. The most characteriztic feature of the SPRR gene family resides in the structure of the central segments of the encoded polypeptides that are built up from tandemly repeated units of either eight (SPRR1 and SPRR3) or nine (SPRR2) amino acids with the general consensus XKXPEPXX where X is any amino acid. In order to avoid bacterial contamination due to the high polar-nature of the HMM the threshold has been set very high.


Pssm-ID: 280537 [Multi-domain]  Cd Length: 135  Bit Score: 68.54  E-value: 1.42e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818657  137 DTMVPGSCSTSTTEPNYTTIHGPCTTNIPDPGCAMVPGPCSTNISEPssepCSTNVREPGYLNASEPTNAKVPDQGYTKI 216
Cdd:pfam02389  26 HSKVPEPCNPKVPEPCCPKVPEPCCPKVPEPCCPKVPEPCCPKVPEP----CYPKVPEPCSPKVPEPCHPKAPEPCHPKV 101

                          90       100       110
                  ....*....|....*....|....*....|....
gi 157818657  217 PDQGYSKVPEPCQSRTPEVCPTTVTPGLAQQKTK 250
Cdd:pfam02389 102 PEPCYPKAPEPCQPKVPEPCPSTVTPGPAQQKTK 135
Cornifin pfam02389
Cornifin (SPRR) family; SPRR genes (formerly SPR) encode a novel class of polypeptides (small ...
 5-136 7.92e-11

Cornifin (SPRR) family; SPRR genes (formerly SPR) encode a novel class of polypeptides (small proline rich proteins) that are strongly induced during differentiation of human epidermal keratinocytes in vitro and in vivo. The most characteriztic feature of the SPRR gene family resides in the structure of the central segments of the encoded polypeptides that are built up from tandemly repeated units of either eight (SPRR1 and SPRR3) or nine (SPRR2) amino acids with the general consensus XKXPEPXX where X is any amino acid. In order to avoid bacterial contamination due to the high polar-nature of the HMM the threshold has been set very high.


Pssm-ID: 280537 [Multi-domain]  Cd Length: 135  Bit Score: 58.53  E-value: 7.92e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157818657    5 QQKQPFVAPPQ-PQQHQVKQPCQPppqgkfvpiATSEPCHTGVPQPGNTKIPEPCSTKVPEPGYTVVLEPDYTTVPGSCS 83
Cdd:pfam02389   4 QVKQPCQPPPQePCVPTTKEPCHS---------KVPEPCNPKVPEPCCPKVPEPCCPKVPEPCCPKVPEPCCPKVPEPCY 74

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 157818657   84 TNVTKPDYTTIPGPCSTNIPGPDN-VVPESCSTNITEPNYTTIPGPC-STNIPGP 136
Cdd:pfam02389  75 PKVPEPCSPKVPEPCHPKAPEPCHpKVPEPCYPKAPEPCQPKVPEPCpSTVTPGP 129
Cornifin pfam02389
Cornifin (SPRR) family; SPRR genes (formerly SPR) encode a novel class of polypeptides (small ...
 183-240 1.15e-03

Cornifin (SPRR) family; SPRR genes (formerly SPR) encode a novel class of polypeptides (small proline rich proteins) that are strongly induced during differentiation of human epidermal keratinocytes in vitro and in vivo. The most characteriztic feature of the SPRR gene family resides in the structure of the central segments of the encoded polypeptides that are built up from tandemly repeated units of either eight (SPRR1 and SPRR3) or nine (SPRR2) amino acids with the general consensus XKXPEPXX where X is any amino acid. In order to avoid bacterial contamination due to the high polar-nature of the HMM the threshold has been set very high.


Pssm-ID: 280537 [Multi-domain]  Cd Length: 135  Bit Score: 38.11  E-value: 1.15e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 157818657  183 PSSEPCSTNVREPGYLNASEPTNAKVPDQGYTKIPDQGYSKVPEPCQSRTPEVCPTTV 240
Cdd:pfam02389  12 PPQEPCVPTTKEPCHSKVPEPCNPKVPEPCCPKVPEPCCPKVPEPCCPKVPEPCCPKV 69
Cornifin pfam02389
Cornifin (SPRR) family; SPRR genes (formerly SPR) encode a novel class of polypeptides (small ...
 14-88 1.62e-03

Cornifin (SPRR) family; SPRR genes (formerly SPR) encode a novel class of polypeptides (small proline rich proteins) that are strongly induced during differentiation of human epidermal keratinocytes in vitro and in vivo. The most characteriztic feature of the SPRR gene family resides in the structure of the central segments of the encoded polypeptides that are built up from tandemly repeated units of either eight (SPRR1 and SPRR3) or nine (SPRR2) amino acids with the general consensus XKXPEPXX where X is any amino acid. In order to avoid bacterial contamination due to the high polar-nature of the HMM the threshold has been set very high.


Pssm-ID: 280537 [Multi-domain]  Cd Length: 135  Bit Score: 37.73  E-value: 1.62e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 157818657   14 PQPQQHQVKQPCQPPPQGKFVPIAtSEPCHTGVPQPGNTKIPEPCSTKVPEPGYTVVLEPDYTTVPGSCSTNVTK 88
Cdd:pfam02389  62 PEPCCPKVPEPCYPKVPEPCSPKV-PEPCHPKAPEPCHPKVPEPCYPKAPEPCQPKVPEPCPSTVTPGPAQQKTK 135
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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