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Conserved domains on  [gi|157820821|ref|NP_001100129|]
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U4/U6 small nuclear ribonucleoprotein Prp4 [Rattus norvegicus]

Protein Classification

U4/U6 small nuclear ribonucleoprotein Prp4 family protein( domain architecture ID 10649556)

U4/U6 small nuclear ribonucleoprotein Prp4 family protein may play a role in pre-mRNA splicing as a component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as a component of the precatalytic spliceosome

CATH:  2.130.10.10
Gene Ontology:  GO:0008380|GO:0005681|GO:0005515
PubMed:  30069656|29026209|21468892
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
228-518 1.40e-84

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 267.55  E-value: 1.40e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157820821 228 GDDRPISYCHFSPNSKMLATACWSGLCKLWSVPDCSLLHTLRGHNTNVGAIVFHPKSTVsldqkdvnLASCAADGSVKLW 307
Cdd:COG2319  118 GHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKL--------LASGSDDGTVRLW 189

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157820821 308 SLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAF 387
Cdd:COG2319  190 DLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGT 269

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157820821 388 GRVWDLRTGRCIMFLEGHLKEIYGISFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPiHGDFLLTG 467
Cdd:COG2319  270 VRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKTLASG 348

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 157820821 468 AYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 518
Cdd:COG2319  349 SDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLW 399
SFM smart00500
Splicing Factor Motif, present in Prp18 and Pr04;
102-140 3.57e-15

Splicing Factor Motif, present in Prp18 and Pr04;


:

Pssm-ID: 128776  Cd Length: 44  Bit Score: 69.31  E-value: 3.57e-15
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 157820821   102 TDDSEVKACLRALGEPITLFGEGPAERRERLRNILSVVG 140
Cdd:smart00500   1 LPDSEVIRRLRELGEPITLFGEDDQERRQRLRQLLIVQD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
228-518 1.40e-84

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 267.55  E-value: 1.40e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157820821 228 GDDRPISYCHFSPNSKMLATACWSGLCKLWSVPDCSLLHTLRGHNTNVGAIVFHPKSTVsldqkdvnLASCAADGSVKLW 307
Cdd:COG2319  118 GHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKL--------LASGSDDGTVRLW 189

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157820821 308 SLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAF 387
Cdd:COG2319  190 DLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGT 269

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157820821 388 GRVWDLRTGRCIMFLEGHLKEIYGISFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPiHGDFLLTG 467
Cdd:COG2319  270 VRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKTLASG 348

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 157820821 468 AYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 518
Cdd:COG2319  349 SDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 232-518 6.73e-80

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 251.49  E-value: 6.73e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157820821 232 PISYCHFSPNSKMLATACWSGLCKLWSVPDCSLLHTLRGHNTNVGAIVFHPKSTVsldqkdvnLASCAADGSVKLWSLDS 311
Cdd:cd00200   11 GVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTY--------LASGSSDKTIRLWDLET 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157820821 312 DEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVW 391
Cdd:cd00200   83 GECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLW 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157820821 392 DLRTGRCIMFLEGHLKEIYGISFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPiHGDFLLTGAYDN 471
Cdd:cd00200  163 DLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSP-DGYLLASGSEDG 241

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 157820821 472 TAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 518
Cdd:cd00200  242 TIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
SFM smart00500
Splicing Factor Motif, present in Prp18 and Pr04;
102-140 3.57e-15

Splicing Factor Motif, present in Prp18 and Pr04;


Pssm-ID: 128776  Cd Length: 44  Bit Score: 69.31  E-value: 3.57e-15
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 157820821   102 TDDSEVKACLRALGEPITLFGEGPAERRERLRNILSVVG 140
Cdd:smart00500   1 LPDSEVIRRLRELGEPITLFGEDDQERRQRLRQLLIVQD 39
PRP4 pfam08799
pre-mRNA processing factor 4 (PRP4) like; This small domain is found on PRP4 ribonuleoproteins. ...
 107-135 6.54e-12

pre-mRNA processing factor 4 (PRP4) like; This small domain is found on PRP4 ribonuleoproteins. PRP4 is a U4/U6 small nuclear ribonucleoprotein that is involved in pre-mRNA processing.


Pssm-ID: 462606 [Multi-domain]  Cd Length: 29  Bit Score: 59.62  E-value: 6.54e-12
                          10        20
                  ....*....|....*....|....*....
gi 157820821  107 VKACLRALGEPITLFGEGPAERRERLRNI 135
Cdd:pfam08799   1 VRRKLRELGEPITLFGETHADRRERLRKL 29
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 395-434 1.48e-10

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 56.17  E-value: 1.48e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 157820821   395 TGRCIMFLEGHLKEIYGISFSPNGYHIATGSGDNTCKVWD 434
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
396-434 1.85e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 53.12  E-value: 1.85e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 157820821  396 GRCIMFLEGHLKEIYGISFSPNGYHIATGSGDNTCKVWD 434
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 227-366 3.34e-07

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 52.97  E-value: 3.34e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157820821 227 IGDDRPISYCHFSP-NSKMLATACWSGLCKLWSVP------DCS--LLHtLRGHNTNVGAIVFHPKStvsldqKDVnLAS 297
Cdd:PTZ00421  72 LGQEGPIIDVAFNPfDPQKLFTASEDGTIMGWGIPeegltqNISdpIVH-LQGHTKKVGIVSFHPSA------MNV-LAS 143

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 157820821 298 CAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMG 366
Cdd:PTZ00421 144 AGADMVVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASA 212
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
228-518 1.40e-84

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 267.55  E-value: 1.40e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157820821 228 GDDRPISYCHFSPNSKMLATACWSGLCKLWSVPDCSLLHTLRGHNTNVGAIVFHPKSTVsldqkdvnLASCAADGSVKLW 307
Cdd:COG2319  118 GHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKL--------LASGSDDGTVRLW 189

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157820821 308 SLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAF 387
Cdd:COG2319  190 DLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGT 269

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157820821 388 GRVWDLRTGRCIMFLEGHLKEIYGISFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPiHGDFLLTG 467
Cdd:COG2319  270 VRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKTLASG 348

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 157820821 468 AYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 518
Cdd:COG2319  349 SDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 232-518 6.73e-80

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 251.49  E-value: 6.73e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157820821 232 PISYCHFSPNSKMLATACWSGLCKLWSVPDCSLLHTLRGHNTNVGAIVFHPKSTVsldqkdvnLASCAADGSVKLWSLDS 311
Cdd:cd00200   11 GVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTY--------LASGSSDKTIRLWDLET 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157820821 312 DEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVW 391
Cdd:cd00200   83 GECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLW 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157820821 392 DLRTGRCIMFLEGHLKEIYGISFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPiHGDFLLTGAYDN 471
Cdd:cd00200  163 DLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSP-DGYLLASGSEDG 241

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 157820821 472 TAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 518
Cdd:cd00200  242 TIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
228-518 2.04e-76

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 246.36  E-value: 2.04e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157820821 228 GDDRPISYCHFSPNSKMLATACWSGLCKLWSVPDCSLLHTLRGHNTNVGAIVFHPKSTVsldqkdvnLASCAADGSVKLW 307
Cdd:COG2319   76 GHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKT--------LASGSADGTVRLW 147

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157820821 308 SLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAF 387
Cdd:COG2319  148 DLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGT 227

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157820821 388 GRVWDLRTGRCIMFLEGHLKEIYGISFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPiHGDFLLTG 467
Cdd:COG2319  228 VRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSP-DGKLLASG 306

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 157820821 468 AYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 518
Cdd:COG2319  307 SDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLW 357
WD40 COG2319
WD40 repeat [General function prediction only];
238-518 4.82e-68

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 224.41  E-value: 4.82e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157820821 238 FSPNSKMLATACWSGLCKLWSVPDCSLLHTLRGHNTNVGAIVFHPKSTVsldqkdvnLASCAADGSVKLWSLDSDEPVAD 317
Cdd:COG2319   44 ASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRL--------LASASADGTVRLWDLATGLLLRT 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157820821 318 IEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGR 397
Cdd:COG2319  116 LTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGK 195

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157820821 398 CIMFLEGHLKEIYGISFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPiHGDFLLTGAYDNTAKIWT 477
Cdd:COG2319  196 LLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSP-DGRLLASGSADGTVRLWD 274

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 157820821 478 HPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 518
Cdd:COG2319  275 LATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLW 315
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 314-518 3.71e-57

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 192.16  E-value: 3.71e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157820821 314 PVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDL 393
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157820821 394 RTGRCIMFLEGHLKEIYGISFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPiHGDFLLTGAYDNTA 473
Cdd:cd00200   81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSP-DGTFVASSSQDGTI 159

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 157820821 474 KIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 518
Cdd:cd00200  160 KLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLW 204
WD40 COG2319
WD40 repeat [General function prediction only];
228-436 1.42e-53

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 186.27  E-value: 1.42e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157820821 228 GDDRPISYCHFSPNSKMLATACWSGLCKLWSVPDCSLLHTLRGHNTNVGAIVFHPKSTVsldqkdvnLASCAADGSVKLW 307
Cdd:COG2319  202 GHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRL--------LASGSADGTVRLW 273

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157820821 308 SLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAF 387
Cdd:COG2319  274 DLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGT 353

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 157820821 388 GRVWDLRTGRCIMFLEGHLKEIYGISFSPNGYHIATGSGDNTCKVWDLR 436
Cdd:COG2319  354 VRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
287-518 6.31e-50

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 176.26  E-value: 6.31e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157820821 287 SLDQKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMG 366
Cdd:COG2319    1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157820821 367 VYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGISFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPA 446
Cdd:COG2319   81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTG 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 157820821 447 HQNLVTGVKFEPiHGDFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 518
Cdd:COG2319  161 HSGAVTSVAFSP-DGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLW 231
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 228-434 3.70e-45

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 160.19  E-value: 3.70e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157820821 228 GDDRPISYCHFSPNSKMLATACWSGLCKLWSVPDCSLLHTLRGHNTNVGAIVFHPKSTVsldqkdvnLASCAADGSVKLW 307
Cdd:cd00200   91 GHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTF--------VASSSQDGTIKLW 162

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157820821 308 SLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAF 387
Cdd:cd00200  163 DLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGT 242

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 157820821 388 GRVWDLRTGRCIMFLEGHLKEIYGISFSPNGYHIATGSGDNTCKVWD 434
Cdd:cd00200  243 IRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
228-395 4.16e-36

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 138.51  E-value: 4.16e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157820821 228 GDDRPISYCHFSPNSKMLATACWSGLCKLWSVPDCSLLHTLRGHNTNVGAIVFHPKSTVsldqkdvnLASCAADGSVKLW 307
Cdd:COG2319  244 GHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKL--------LASGSDDGTVRLW 315

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157820821 308 SLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAF 387
Cdd:COG2319  316 DLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGT 395


                 ....*...
gi 157820821 388 GRVWDLRT 395
Cdd:COG2319  396 VRLWDLAT 403
SFM smart00500
Splicing Factor Motif, present in Prp18 and Pr04;
102-140 3.57e-15

Splicing Factor Motif, present in Prp18 and Pr04;


Pssm-ID: 128776  Cd Length: 44  Bit Score: 69.31  E-value: 3.57e-15
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 157820821   102 TDDSEVKACLRALGEPITLFGEGPAERRERLRNILSVVG 140
Cdd:smart00500   1 LPDSEVIRRLRELGEPITLFGEDDQERRQRLRQLLIVQD 39
PRP4 pfam08799
pre-mRNA processing factor 4 (PRP4) like; This small domain is found on PRP4 ribonuleoproteins. ...
 107-135 6.54e-12

pre-mRNA processing factor 4 (PRP4) like; This small domain is found on PRP4 ribonuleoproteins. PRP4 is a U4/U6 small nuclear ribonucleoprotein that is involved in pre-mRNA processing.


Pssm-ID: 462606 [Multi-domain]  Cd Length: 29  Bit Score: 59.62  E-value: 6.54e-12
                          10        20
                  ....*....|....*....|....*....
gi 157820821  107 VKACLRALGEPITLFGEGPAERRERLRNI 135
Cdd:pfam08799   1 VRRKLRELGEPITLFGETHADRRERLRKL 29
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 216-308 6.15e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 63.12  E-value: 6.15e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157820821 216 SLRSLNNFCSQIGDDRPISYCHFSPNSKMLATACWSGLCKLWSVPDCSLLHTLRGHNTNVGAIVFHPKSTVsldqkdvnL 295
Cdd:cd00200  205 DLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKR--------L 276

                         90
                 ....*....|...
gi 157820821 296 ASCAADGSVKLWS 308
Cdd:cd00200  277 ASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 395-434 1.48e-10

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 56.17  E-value: 1.48e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 157820821   395 TGRCIMFLEGHLKEIYGISFSPNGYHIATGSGDNTCKVWD 434
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
396-434 1.85e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 53.12  E-value: 1.85e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 157820821  396 GRCIMFLEGHLKEIYGISFSPNGYHIATGSGDNTCKVWD 434
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
481-518 2.90e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 49.65  E-value: 2.90e-08
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 157820821  481 WSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 518
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 481-518 2.97e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 49.62  E-value: 2.97e-08
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 157820821   481 WSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 518
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
PTZ00421 PTZ00421
coronin; Provisional
 227-366 3.34e-07

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 52.97  E-value: 3.34e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157820821 227 IGDDRPISYCHFSP-NSKMLATACWSGLCKLWSVP------DCS--LLHtLRGHNTNVGAIVFHPKStvsldqKDVnLAS 297
Cdd:PTZ00421  72 LGQEGPIIDVAFNPfDPQKLFTASEDGTIMGWGIPeegltqNISdpIVH-LQGHTKKVGIVSFHPSA------MNV-LAS 143

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 157820821 298 CAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMG 366
Cdd:PTZ00421 144 AGADMVVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASA 212
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 377-518 2.34e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 50.47  E-value: 2.34e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157820821 377 SLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGISFSP-NGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNlVTGVK 455
Cdd:PLN00181 546 SQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGTIKTKAN-ICCVQ 624

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 157820821 456 FEPIHGDFLLTGAYDNTAKIWT--HPGWsPLKTLAGHEGKVMGLDISSDGQLIATcSYDRTFKLW 518
Cdd:PLN00181 625 FPSESGRSLAFGSADHKVYYYDlrNPKL-PLCTMIGHSKTVSYVRFVDSSTLVSS-STDNTLKLW 687
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 311-350 5.68e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.07  E-value: 5.68e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 157820821   311 SDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWD 350
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
438-476 1.23e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.33  E-value: 1.23e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 157820821  438 RRCVYTIPAHQNLVTGVKFEPiHGDFLLTGAYDNTAKIW 476
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 437-476 1.25e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.30  E-value: 1.25e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 157820821   437 QRRCVYTIPAHQNLVTGVKFEPiHGDFLLTGAYDNTAKIW 476
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
313-350 4.23e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.79  E-value: 4.23e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 157820821  313 EPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWD 350
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 225-433 4.93e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 46.23  E-value: 4.93e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157820821 225 SQIGDDRPISY--CHFSPNSKmLATACWS-------------GLCKLWSVPDCSLLHTLRGHNTNVGAIVFHPKSTVSLd 289
Cdd:PLN00181 514 SIIKDGRDIHYpvVELASRSK-LSGICWNsyiksqvassnfeGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLL- 591

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157820821 290 qkdvnlASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQE-EILHQEGHSMGVY 368
Cdd:PLN00181 592 ------ASGSDDGSVKLWSINQGVSIGTIKTKANICCVQFPSESGRSLAFGSADHKVYYYDLRNPKlPLCTMIGHSKTVS 665

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 157820821 369 DIAFhQDGSLAGTGGLDAFGRVWDLRTGRC------IMFLEGH--LKEIYGISFSpNGYhIATGSGDNTCKVW 433
Cdd:PLN00181 666 YVRF-VDSSTLVSSSTDNTLKLWDLSMSISginetpLHSFMGHtnVKNFVGLSVS-DGY-IATGSETNEVFVY 735
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 263-308 8.22e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.99  E-value: 8.22e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 157820821   263 SLLHTLRGHNTNVGAIVFHPKSTVsldqkdvnLASCAADGSVKLWS 308
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKY--------LASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
263-308 1.35e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.25  E-value: 1.35e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 157820821  263 SLLHTLRGHNTNVGAIVFHPKSTVsldqkdvnLASCAADGSVKLWS 308
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKL--------LASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 319-448 1.46e-04

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 44.50  E-value: 1.46e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157820821 319 EGHTVRVARVMWHPSGRFlgTTCYDRSWRLWDLEAQ-------EEILHQEGHSMGVYDIAFH--QDGSLAgTGGLDAFGR 389
Cdd:PTZ00421  75 EGPIIDVAFNPFDPQKLF--TASEDGTIMGWGIPEEgltqnisDPIVHLQGHTKKVGIVSFHpsAMNVLA-SAGADMVVN 151

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 157820821 390 VWDLRTGRCIMFLEGHLKEIYGISFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQ 448
Cdd:PTZ00421 152 VWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHA 210
PTZ00420 PTZ00420
coronin; Provisional
 268-433 2.98e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 43.40  E-value: 2.98e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157820821 268 LRGHNTNVGAIVFHP-KSTVsldqkdvnLASCAADGSVKLWSL-DSDEPVADIE-------GHTVRVARVMWHPSGRF-L 337
Cdd:PTZ00420  70 LKGHTSSILDLQFNPcFSEI--------LASGSEDLTIRVWEIpHNDESVKEIKdpqcilkGHKKKISIIDWNPMNYYiM 141

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157820821 338 GTTCYDRSWRLWDLEAQE---EILHQEGHSMGVYDIAfhqdGS-LAGTGgldafgrvwdlrTGRCIMFLEGHLKEIygis 413
Cdd:PTZ00420 142 CSSGFDSFVNIWDIENEKrafQINMPKKLSSLKWNIK----GNlLSGTC------------VGKHMHIIDPRKQEI---- 201

                        170       180
                 ....*....|....*....|
gi 157820821 414 fsPNGYHIATGsGDNTCKVW 433
Cdd:PTZ00420 202 --ASSFHIHDG-GKNTKNIW 218
WD40 pfam00400
WD domain, G-beta repeat;
361-392 8.01e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.94  E-value: 8.01e-04
                          10        20        30
                  ....*....|....*....|....*....|..
gi 157820821  361 EGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWD 392
Cdd:pfam00400   8 EGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 228-258 2.47e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.75  E-value: 2.47e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 157820821   228 GDDRPISYCHFSPNSKMLATACWSGLCKLWS 258
Cdd:smart00320  10 GHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 361-392 2.50e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.75  E-value: 2.50e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 157820821   361 EGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWD 392
Cdd:smart00320   9 KGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
CDC55 COG5170
Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms];
401-450 3.35e-03

Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms];


Pssm-ID: 227498 [Multi-domain]  Cd Length: 460  Bit Score: 40.01  E-value: 3.35e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 157820821 401 FLEGHLKEIYGISFSPNGYHIATGSgDNTCKVWDLR-QRRCVYTIPAHQNL 450
Cdd:COG5170  275 FFEEIVSSISDFKFSDNGRYILSRD-YLTVKIWDVNmAKNPIKTIPMHCDL 324
PTZ00420 PTZ00420
coronin; Provisional
 361-444 3.52e-03

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 39.93  E-value: 3.52e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157820821 361 EGHSMGVYDIAFHQDGS-LAGTGGLDAFGRVWDLRTG----------RCImfLEGHLKEIYGISFSPNGYHIATGSG-DN 428
Cdd:PTZ00420  71 KGHTSSILDLQFNPCFSeILASGSEDLTIRVWEIPHNdesvkeikdpQCI--LKGHKKKISIIDWNPMNYYIMCSSGfDS 148

                         90
                 ....*....|....*.
gi 157820821 429 TCKVWDLRQRRCVYTI 444
Cdd:PTZ00420 149 FVNIWDIENEKRAFQI 164
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 389-452 3.78e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 36.87  E-value: 3.78e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 157820821  389 RVWDLrtgrcimFLEGHLKEIYGISFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVT 452
Cdd:pfam12894  28 RVWTL-------SPDKEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLIT 84
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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