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Conserved domains on  [gi|157787028|ref|NP_001099452|]
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sushi domain-containing protein 4 [Rattus norvegicus]

Protein Classification

beta-2-glycoprotein 1( domain architecture ID 13269567)

beta-2-glycoprotein 1 is a heavily glycosylated plasma membrane-adhesion protein, which plays a role in blood coagulation and removal of apoptotic bodies

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PHA02639 super family cl31493
EEV host range protein; Provisional
 30-238 1.27e-14

EEV host range protein; Provisional


The actual alignment was detected with superfamily member PHA02639:

Pssm-ID: 165022 [Multi-domain]  Cd Length: 295  Bit Score: 74.32  E-value: 1.27e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157787028  30 LAVILWFQLALCFgpaqlTGGFDDLnVCADPGVPENGFRTPSGGVFFESSVARFHCQDGFKLKGSSKRLCVKRLNGTLgW 109
Cdd:PHA02639   1 MKIILYLFIGVCY-----VHGVKSI-YCDKPDDISNGFITELMEKYEIGKLIEYTCNTDYALIGDRFRTCIKDKNNAI-W 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157787028 110 iPSDKPLCIQEDCR-IPRIEDAEIHNK--TYRHGDKLIINCHEGFKIRYPDLYNMVSLCRDDGTWD-NLPICQ--GCLRP 183
Cdd:PHA02639  74 -SNKAPFCMLKECNdPPSIINGKIYNKreMYKVGDEIYYVCNEHKGVQYSLVGNEKITCIQDKSWKpDPPICKmiNCRFP 152

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 157787028 184 lASSNGYVNISEFQTSFPVGTVIAYRCFPGFKLEGSEYLECLHNLIWSSSPPRCL 238
Cdd:PHA02639 153 -ALQNGYINGIPSNKKFYYKTRVGFSCKSGFDLVGEKYSTCNINATWFPSIPTCV 206
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 243-297 4.29e-08

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


:

Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 49.45  E-value: 4.29e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 157787028   243 CPLPPMVSHGDFICHPRPcerYNHGTVVEFYCDPGYSLTSDyKYITCQ-YGEWFPS 297
Cdd:smart00032   1 CPPPPDIENGTVTSSSGT---YSYGDTVTYSCDPGYTLIGS-STITCLeNGTWSPP 52
 
Name Accession Description Interval E-value
PHA02639 PHA02639
EEV host range protein; Provisional
 30-238 1.27e-14

EEV host range protein; Provisional


Pssm-ID: 165022 [Multi-domain]  Cd Length: 295  Bit Score: 74.32  E-value: 1.27e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157787028  30 LAVILWFQLALCFgpaqlTGGFDDLnVCADPGVPENGFRTPSGGVFFESSVARFHCQDGFKLKGSSKRLCVKRLNGTLgW 109
Cdd:PHA02639   1 MKIILYLFIGVCY-----VHGVKSI-YCDKPDDISNGFITELMEKYEIGKLIEYTCNTDYALIGDRFRTCIKDKNNAI-W 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157787028 110 iPSDKPLCIQEDCR-IPRIEDAEIHNK--TYRHGDKLIINCHEGFKIRYPDLYNMVSLCRDDGTWD-NLPICQ--GCLRP 183
Cdd:PHA02639  74 -SNKAPFCMLKECNdPPSIINGKIYNKreMYKVGDEIYYVCNEHKGVQYSLVGNEKITCIQDKSWKpDPPICKmiNCRFP 152

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 157787028 184 lASSNGYVNISEFQTSFPVGTVIAYRCFPGFKLEGSEYLECLHNLIWSSSPPRCL 238
Cdd:PHA02639 153 -ALQNGYINGIPSNKKFYYKTRVGFSCKSGFDLVGEKYSTCNINATWFPSIPTCV 206
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 180-237 7.33e-11

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 57.47  E-value: 7.33e-11
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 157787028 180 CLRPLASSNGYVNISefQTSFPVGTVIAYRCFPGFKLEGSEYLECLHNLIWSSSPPRC 237
Cdd:cd00033    1 CPPPPVPENGTVTGS--KGSYSYGSTVTYSCNEGYTLVGSSTITCTENGGWSPPPPTC 56
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 180-237 6.95e-10

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 54.84  E-value: 6.95e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 157787028   180 CLRPLASSNGYVNISefQTSFPVGTVIAYRCFPGFKLEGSEYLECLHNLIWSSSPPRC 237
Cdd:smart00032   1 CPPPPDIENGTVTSS--SGTYSYGDTVTYSCDPGYTLIGSSTITCLENGTWSPPPPTC 56
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 243-297 4.29e-08

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 49.45  E-value: 4.29e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 157787028   243 CPLPPMVSHGDFICHPRPcerYNHGTVVEFYCDPGYSLTSDyKYITCQ-YGEWFPS 297
Cdd:smart00032   1 CPPPPDIENGTVTSSSGT---YSYGDTVTYSCDPGYTLIGS-STITCLeNGTWSPP 52
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 243-294 8.68e-08

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 48.61  E-value: 8.68e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 157787028 243 CPLPPMVSHGDFICHPrpcERYNHGTVVEFYCDPGYSLTSDyKYITCQ-YGEW 294
Cdd:cd00033    1 CPPPPVPENGTVTGSK---GSYSYGSTVTYSCNEGYTLVGS-STITCTeNGGW 49
Sushi pfam00084
Sushi repeat (SCR repeat);
190-237 1.62e-07

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 47.88  E-value: 1.62e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 157787028  190 YVNISEFQTSFPVGTVIAYRCFPGFKLEGSEYLECLHNLIWSSSPPRC 237
Cdd:pfam00084   9 NGKVSATKNEYNYGASVSYECDPGYRLVGSPTITCQEDGTWSPPFPEC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
243-294 9.43e-06

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 42.87  E-value: 9.43e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 157787028  243 CPLPPMVSHGDFIChprPCERYNHGTVVEFYCDPGYSLTSDYKyITCQ-YGEW 294
Cdd:pfam00084   1 CPPPPDIPNGKVSA---TKNEYNYGASVSYECDPGYRLVGSPT-ITCQeDGTW 49
 
Name Accession Description Interval E-value
PHA02639 PHA02639
EEV host range protein; Provisional
 30-238 1.27e-14

EEV host range protein; Provisional


Pssm-ID: 165022 [Multi-domain]  Cd Length: 295  Bit Score: 74.32  E-value: 1.27e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157787028  30 LAVILWFQLALCFgpaqlTGGFDDLnVCADPGVPENGFRTPSGGVFFESSVARFHCQDGFKLKGSSKRLCVKRLNGTLgW 109
Cdd:PHA02639   1 MKIILYLFIGVCY-----VHGVKSI-YCDKPDDISNGFITELMEKYEIGKLIEYTCNTDYALIGDRFRTCIKDKNNAI-W 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157787028 110 iPSDKPLCIQEDCR-IPRIEDAEIHNK--TYRHGDKLIINCHEGFKIRYPDLYNMVSLCRDDGTWD-NLPICQ--GCLRP 183
Cdd:PHA02639  74 -SNKAPFCMLKECNdPPSIINGKIYNKreMYKVGDEIYYVCNEHKGVQYSLVGNEKITCIQDKSWKpDPPICKmiNCRFP 152

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 157787028 184 lASSNGYVNISEFQTSFPVGTVIAYRCFPGFKLEGSEYLECLHNLIWSSSPPRCL 238
Cdd:PHA02639 153 -ALQNGYINGIPSNKKFYYKTRVGFSCKSGFDLVGEKYSTCNINATWFPSIPTCV 206
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 57-238 2.05e-13

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 70.07  E-value: 2.05e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157787028  57 CADPGVPENGfRTPSGGVFFESSVArFHCQDGFKLKGSSKRLCVKRLNGTLGWIPsDKPLCIQEDCRIPRIEDAEIHN-- 134
Cdd:PHA02927  86 CPSPRDIDNG-QLDIGGVDFGSSIT-YSCNSGYQLIGESKSYCELGSTGSMVWNP-EAPICESVKCQSPPSISNGRHNgy 162

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157787028 135 -KTYRHGDKLIINCHEGFKIrypdLYNMVSLCrDDGTWDNLPICQ--GCLRPlASSNGYVNiSEFQTSFPVGTVIAYRCF 211
Cdd:PHA02927 163 eDFYTDGSVVTYSCNSGYSL----IGNSGVLC-SGGEWSDPPTCQivKCPHP-TISNGYLS-SGFKRSYSYNDNVDFKCK 235

                        170       180
                 ....*....|....*....|....*..
gi 157787028 212 PGFKLEGSEYLECLHNLIWSSSPPRCL 238
Cdd:PHA02927 236 YGYKLSGSSSSTCSPGNTWQPELPKCV 262
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 180-237 7.33e-11

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 57.47  E-value: 7.33e-11
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 157787028 180 CLRPLASSNGYVNISefQTSFPVGTVIAYRCFPGFKLEGSEYLECLHNLIWSSSPPRC 237
Cdd:cd00033    1 CPPPPVPENGTVTGS--KGSYSYGSTVTYSCNEGYTLVGSSTITCTENGGWSPPPPTC 56
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 180-237 6.95e-10

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 54.84  E-value: 6.95e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 157787028   180 CLRPLASSNGYVNISefQTSFPVGTVIAYRCFPGFKLEGSEYLECLHNLIWSSSPPRC 237
Cdd:smart00032   1 CPPPPDIENGTVTSS--SGTYSYGDTVTYSCDPGYTLIGSSTITCLENGTWSPPPPTC 56
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 134-294 2.97e-09

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 57.74  E-value: 2.97e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157787028 134 NKTYRHGDKLIINCHEGFkiRYPDLYNMVSLCRDDG-TWDNLPICQGCLRPLASSNGYVNISefqtSFPVGTVIAYRCFP 212
Cdd:PHA02927  41 NANYNIGDTIEYLCLPGY--RKQKMGPIYAKCTGTGwTLFNQCIKRRCPSPRDIDNGQLDIG----GVDFGSSITYSCNS 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157787028 213 GFKLEGSEYLEC----LHNLIWSSSPPRCLALEvCPLPPMVSHGDficHPRPCERYNHGTVVEFYCDPGYSLTSDYKyIT 288
Cdd:PHA02927 115 GYQLIGESKSYCelgsTGSMVWNPEAPICESVK-CQSPPSISNGR---HNGYEDFYTDGSVVTYSCNSGYSLIGNSG-VL 189


                 ....*.
gi 157787028 289 CQYGEW 294
Cdd:PHA02927 190 CSGGEW 195
PHA02831 PHA02831
EEV host range protein; Provisional
 74-238 2.20e-08

EEV host range protein; Provisional


Pssm-ID: 165176 [Multi-domain]  Cd Length: 268  Bit Score: 55.38  E-value: 2.20e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157787028  74 VFFESSVARFHCQDGFKlkgsskRLCVKRLNGTlgWipSDKPLCI-QEDCRIP-RIEDAEIHNKT--YRHGDKLIINCHE 149
Cdd:PHA02831  39 VYEENENLEYKCNNNFD------KVFVTCNNGS--W--STKNMCIgKRNCKDPvTILNGYIKNKKdqYSFGDSVTYACKV 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157787028 150 GFKIRYPDLYNMVSLCRDdGTW--DNlPICQ--GCLRPlASSNGYVNIseFQTSFPVGTVIAYRCFPGFKLEGSEYLECL 225
Cdd:PHA02831 109 NKLEKYSIVGNETVKCIN-KQWvpKY-PVCKliRCKYP-ALQNGFLNV--FEKKFYYGDIVNFKCKKGFILLGSSVSTCD 183

                        170
                 ....*....|...
gi 157787028 226 HNLIWSSSPPRCL 238
Cdd:PHA02831 184 INSIWYPGIPKCV 196
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 243-297 4.29e-08

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 49.45  E-value: 4.29e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 157787028   243 CPLPPMVSHGDFICHPRPcerYNHGTVVEFYCDPGYSLTSDyKYITCQ-YGEWFPS 297
Cdd:smart00032   1 CPPPPDIENGTVTSSSGT---YSYGDTVTYSCDPGYTLIGS-STITCLeNGTWSPP 52
PHA02817 PHA02817
EEV Host range protein; Provisional
 117-237 4.67e-08

EEV Host range protein; Provisional


Pssm-ID: 165167 [Multi-domain]  Cd Length: 225  Bit Score: 53.79  E-value: 4.67e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157787028 117 CIQEDCRIP-RIEDAEIHNK--TYRHGDKLIINCHEGFK-IRYPDLYNMVSLCRDDGTWD-NLPICQ--GCLRPlASSNG 189
Cdd:PHA02817  19 CDLNKCCYPpSIKNGYIYNKktEYNIGSNVTFFCGNNTRgVRYTLVGEKNIICEKDGKWNkEFPVCKiiRCRFP-ALQNG 97

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 157787028 190 YVNISEFQTSFPVGTVIAYRCFPGFKLEGSEYLECLHNLIWSSSPPRC 237
Cdd:PHA02817  98 FVNGIPDSKKFYYESEVSFSCKPGFVLIGTKYSVCGINSSWIPKVPIC 145
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 243-294 8.68e-08

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 48.61  E-value: 8.68e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 157787028 243 CPLPPMVSHGDFICHPrpcERYNHGTVVEFYCDPGYSLTSDyKYITCQ-YGEW 294
Cdd:cd00033    1 CPPPPVPENGTVTGSK---GSYSYGSTVTYSCNEGYTLVGS-STITCTeNGGW 49
Sushi pfam00084
Sushi repeat (SCR repeat);
190-237 1.62e-07

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 47.88  E-value: 1.62e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 157787028  190 YVNISEFQTSFPVGTVIAYRCFPGFKLEGSEYLECLHNLIWSSSPPRC 237
Cdd:pfam00084   9 NGKVSATKNEYNYGASVSYECDPGYRLVGSPTITCQEDGTWSPPFPEC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 57-118 4.13e-07

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 46.69  E-value: 4.13e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 157787028  57 CADPGVPENGFRTPSGGVFFESSVARFHCQDGFKLKGSSKRLCvkRLNGTlgWIPSdKPLCI 118
Cdd:cd00033    1 CPPPPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVGSSTITC--TENGG--WSPP-PPTCE 57
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 57-117 1.20e-06

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 45.60  E-value: 1.20e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 157787028    57 CADPGVPENGFRTPSGGVFFESSVARFHCQDGFKLKGSSKRLCVKrlNGTlgWIPSdKPLC 117
Cdd:smart00032   1 CPPPPDIENGTVTSSSGTYSYGDTVTYSCDPGYTLIGSSTITCLE--NGT--WSPP-PPTC 56
PHA02639 PHA02639
EEV host range protein; Provisional
 180-296 1.92e-06

EEV host range protein; Provisional


Pssm-ID: 165022 [Multi-domain]  Cd Length: 295  Bit Score: 49.66  E-value: 1.92e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157787028 180 CLRPLASSNGYvnISEFQTSFPVGTVIAYRCFPGFKLEGSEYLECL---HNLIWSSSPPRCLaLEVCPLPPMVSHGDfIC 256
Cdd:PHA02639  22 CDKPDDISNGF--ITELMEKYEIGKLIEYTCNTDYALIGDRFRTCIkdkNNAIWSNKAPFCM-LKECNDPPSIINGK-IY 97

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 157787028 257 HPRpcERYNHGTVVEFYCDP----GYSLTSDYKYITCQYGEWFP 296
Cdd:PHA02639  98 NKR--EMYKVGDEIYYVCNEhkgvQYSLVGNEKITCIQDKSWKP 139
Sushi pfam00084
Sushi repeat (SCR repeat);
243-294 9.43e-06

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 42.87  E-value: 9.43e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 157787028  243 CPLPPMVSHGDFIChprPCERYNHGTVVEFYCDPGYSLTSDYKyITCQ-YGEW 294
Cdd:pfam00084   1 CPPPPDIPNGKVSA---TKNEYNYGASVSYECDPGYRLVGSPT-ITCQeDGTW 49
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 117-296 1.18e-05

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 46.95  E-value: 1.18e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157787028 117 CIQEDCRIPR-IEDAEIHNKTYRHGDKLIINCHEGFKIrypdLYNMVSLCRDDGT----WD-NLPICQG--CLRPLASSN 188
Cdd:PHA02927  81 CIKRRCPSPRdIDNGQLDIGGVDFGSSITYSCNSGYQL----IGESKSYCELGSTgsmvWNpEAPICESvkCQSPPSISN 156

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157787028 189 GYVNisEFQTSFPVGTVIAYRCFPGFKLEGSEYLECLHNLiWSSsPPRCLALEvCPlPPMVSHGDFICHPRpcERYNHGT 268
Cdd:PHA02927 157 GRHN--GYEDFYTDGSVVTYSCNSGYSLIGNSGVLCSGGE-WSD-PPTCQIVK-CP-HPTISNGYLSSGFK--RSYSYND 228

                        170       180
                 ....*....|....*....|....*....
gi 157787028 269 VVEFYCDPGYSLTSDYKYiTCQYGE-WFP 296
Cdd:PHA02927 229 NVDFKCKYGYKLSGSSSS-TCSPGNtWQP 256
PHA02831 PHA02831
EEV host range protein; Provisional
 134-304 1.24e-05

EEV host range protein; Provisional


Pssm-ID: 165176 [Multi-domain]  Cd Length: 268  Bit Score: 46.91  E-value: 1.24e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157787028 134 NKTYRHGDKLIINCHEGFkirypdlyNMVSLCRDDGTWDNLPICQG---CLRPLASSNGYVNISEFQTSFpvGTVIAYRC 210
Cdd:PHA02831  37 NKVYEENENLEYKCNNNF--------DKVFVTCNNGSWSTKNMCIGkrnCKDPVTILNGYIKNKKDQYSF--GDSVTYAC 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157787028 211 ----FPGFKLEGSEYLECLhNLIWSSSPPRClALEVCPLPPMvSHGDFICHPRpceRYNHGTVVEFYCDPGY----SLTS 282
Cdd:PHA02831 107 kvnkLEKYSIVGNETVKCI-NKQWVPKYPVC-KLIRCKYPAL-QNGFLNVFEK---KFYYGDIVNFKCKKGFillgSSVS 180

                        170       180
                 ....*....|....*....|...
gi 157787028 283 dykyiTCQYGE-WFPSYQvYCIK 304
Cdd:PHA02831 181 -----TCDINSiWYPGIP-KCVK 197
Sushi pfam00084
Sushi repeat (SCR repeat);
57-117 3.55e-05

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 41.33  E-value: 3.55e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 157787028   57 CADPGVPENGFRTPSGGVFFESSVARFHCQDGFKLKGSSKRLCVKrlNGTlgWIPSDkPLC 117
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNEYNYGASVSYECDPGYRLVGSPTITCQE--DGT--WSPPF-PEC 56
PHA02954 PHA02954
EEV membrane glycoprotein; Provisional
 92-238 3.05e-04

EEV membrane glycoprotein; Provisional


Pssm-ID: 165263 [Multi-domain]  Cd Length: 317  Bit Score: 42.77  E-value: 3.05e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157787028  92 KGSSKRLCVKRLNGTLGWipSDKPLCIQEDCRIPRIEDAEIH--NKTYRHGDKLIINCHEGFKIRYPDLYNMVSlcrddG 169
Cdd:PHA02954 102 KDETKYFRCEEKNGNTSW--NDTVTCPNAECQPLQLEHGSCQpvKEKYSFGEHITINCDVGYEVIGASYISCTA-----N 174

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 157787028 170 TWDNLPICQGCLRPLASSNGYVNISefqtSFPVGTVIAYRCFPGFKLEGSEYLECLHNLiWSSSPPRCL 238
Cdd:PHA02954 175 SWNVIPSCQQKCDIPSLSNGLISGS----TFSIGGVIHLSCKSGFTLTGSPSSTCIDGK-WNPVLPICV 238
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 125-177 3.60e-03

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 35.58  E-value: 3.60e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 157787028   125 PRIEDAEI--HNKTYRHGDKLIINCHEGFKIRYPDlynmVSLCRDDGTWDN-LPIC 177
Cdd:smart00032   5 PDIENGTVtsSSGTYSYGDTVTYSCDPGYTLIGSS----TITCLENGTWSPpPPTC 56
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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