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Conserved domains on  [gi|161077441|ref|NP_001097436|]
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wing morphogenesis defect, isoform B [Drosophila melanogaster]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
7-299 2.50e-60

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 198.21  E-value: 2.50e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077441   7 RQIPLTCSGHTRPVVHLDFSDicDaGYFLISACKDGSPMLRHGDTGDWVGTFEGHKGAVWNATLNRNATLAASGAADFTG 86
Cdd:COG2319  110 GLLLRTLTGHTGAVRSVAFSP--D-GKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTV 186

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077441  87 KVWNAVTGAEIHSFQ-HKHIVKSVAFDRDSENIVTGSNEKLVRVFNLEQPEaQPEEYAGHTGAIKRALFCRGDKCIISAA 165
Cdd:COG2319  187 RLWDLATGKLLRTLTgHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGK-LLRTLTGHSGSVRSVAFSPDGRLLASGS 265

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077441 166 EDKTVRLWDRMTGIEVQRLQFNSNP-NSLEISSD-NHILTISHGSSISFWEIDTLKKLKEVKVPTN-VASASLHPDKHVF 242
Cdd:COG2319  266 ADGTVRLWDLATGELLRTLTGHSGGvNSVAFSPDgKLLASGSDDGTVRLWDLATGKLLRTLTGHTGaVRSVAFSPDGKTL 345

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 161077441 243 VCGGEDFKMYKFDYITGNEIESFKGHFGPVHSVKFSPDGELYASGSEDGTLRLWQTT 299
Cdd:COG2319  346 ASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
7-299 2.50e-60

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 198.21  E-value: 2.50e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077441   7 RQIPLTCSGHTRPVVHLDFSDicDaGYFLISACKDGSPMLRHGDTGDWVGTFEGHKGAVWNATLNRNATLAASGAADFTG 86
Cdd:COG2319  110 GLLLRTLTGHTGAVRSVAFSP--D-GKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTV 186

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077441  87 KVWNAVTGAEIHSFQ-HKHIVKSVAFDRDSENIVTGSNEKLVRVFNLEQPEaQPEEYAGHTGAIKRALFCRGDKCIISAA 165
Cdd:COG2319  187 RLWDLATGKLLRTLTgHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGK-LLRTLTGHSGSVRSVAFSPDGRLLASGS 265

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077441 166 EDKTVRLWDRMTGIEVQRLQFNSNP-NSLEISSD-NHILTISHGSSISFWEIDTLKKLKEVKVPTN-VASASLHPDKHVF 242
Cdd:COG2319  266 ADGTVRLWDLATGELLRTLTGHSGGvNSVAFSPDgKLLASGSDDGTVRLWDLATGKLLRTLTGHTGaVRSVAFSPDGKTL 345

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 161077441 243 VCGGEDFKMYKFDYITGNEIESFKGHFGPVHSVKFSPDGELYASGSEDGTLRLWQTT 299
Cdd:COG2319  346 ASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 12-297 3.03e-50

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 168.67  E-value: 3.03e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077441  12 TCSGHTRPVVHLDFSDICDagyFLISACKDGSPMLRHGDTGDWVGTFEGHKGAVWNATLNRNATLAASGAADFTGKVWNA 91
Cdd:cd00200    4 TLKGHTGGVTCVAFSPDGK---LLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077441  92 VTGAEIHSF-QHKHIVKSVAFDRDSENIVTGSNEKLVRVFNLEQPEAQPEeYAGHTGAIKRALFCRGDKCIISAAEDKTV 170
Cdd:cd00200   81 ETGECVRTLtGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTT-LRGHTDWVNSVAFSPDGTFVASSSQDGTI 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077441 171 RLWDRMTGIEVQRLQFNSNP-NSLEISSDN-HILTISHGSSISFWEIDTLKKLKEVKVPTN-VASASLHPDKHVFVCGGE 247
Cdd:cd00200  160 KLWDLRTGKCVATLTGHTGEvNSVAFSPDGeKLLSSSSDGTIKLWDLSTGKCLGTLRGHENgVNSVAFSPDGYLLASGSE 239

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 161077441 248 DFKMYKFDYITGNEIESFKGHFGPVHSVKFSPDGELYASGSEDGTLRLWQ 297
Cdd:cd00200  240 DGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 258-296 8.76e-10

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 53.47  E-value: 8.76e-10
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 161077441   258 TGNEIESFKGHFGPVHSVKFSPDGELYASGSEDGTLRLW 296
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
259-296 7.33e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 50.81  E-value: 7.33e-09
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 161077441  259 GNEIESFKGHFGPVHSVKFSPDGELYASGSEDGTLRLW 296
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 19-174 1.79e-07

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 52.78  E-value: 1.79e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077441  19 PVVHL----DFSDICDAGYF---LISACKDGSPMLRHGDTGDWVGTFEGHKGAVWNATLNR-NATLAASGAADFTGKVWN 90
Cdd:PLN00181 525 PVVELasrsKLSGICWNSYIksqVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWS 604

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077441  91 AVTGAEIHSFQHKHIVKSVAFDRDS-ENIVTGSNEKLVRVFNLEQPEAQPEEYAGHTGAIKRALFCrGDKCIISAAEDKT 169
Cdd:PLN00181 605 INQGVSIGTIKTKANICCVQFPSESgRSLAFGSADHKVYYYDLRNPKLPLCTMIGHSKTVSYVRFV-DSSTLVSSSTDNT 683


                 ....*
gi 161077441 170 VRLWD 174
Cdd:PLN00181 684 LKLWD 688
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
7-299 2.50e-60

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 198.21  E-value: 2.50e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077441   7 RQIPLTCSGHTRPVVHLDFSDicDaGYFLISACKDGSPMLRHGDTGDWVGTFEGHKGAVWNATLNRNATLAASGAADFTG 86
Cdd:COG2319  110 GLLLRTLTGHTGAVRSVAFSP--D-GKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTV 186

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077441  87 KVWNAVTGAEIHSFQ-HKHIVKSVAFDRDSENIVTGSNEKLVRVFNLEQPEaQPEEYAGHTGAIKRALFCRGDKCIISAA 165
Cdd:COG2319  187 RLWDLATGKLLRTLTgHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGK-LLRTLTGHSGSVRSVAFSPDGRLLASGS 265

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077441 166 EDKTVRLWDRMTGIEVQRLQFNSNP-NSLEISSD-NHILTISHGSSISFWEIDTLKKLKEVKVPTN-VASASLHPDKHVF 242
Cdd:COG2319  266 ADGTVRLWDLATGELLRTLTGHSGGvNSVAFSPDgKLLASGSDDGTVRLWDLATGKLLRTLTGHTGaVRSVAFSPDGKTL 345

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 161077441 243 VCGGEDFKMYKFDYITGNEIESFKGHFGPVHSVKFSPDGELYASGSEDGTLRLWQTT 299
Cdd:COG2319  346 ASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
2-302 5.84e-57

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 189.35  E-value: 5.84e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077441   2 AANNLRQIPLTCSGHTRPVVHLDFSDicdAGYFLISACKDGSPMLRHGDTGDWVGTFEGHKGAVWNATLNRNATLAASGA 81
Cdd:COG2319   63 LDAAAGALLATLLGHTAAVLSVAFSP---DGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGS 139

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077441  82 ADFTGKVWNAVTGAEIHSFQ-HKHIVKSVAFDRDSENIVTGSNEKLVRVFNLEQPEaQPEEYAGHTGAIKRALFCRGDKC 160
Cdd:COG2319  140 ADGTVRLWDLATGKLLRTLTgHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGK-LLRTLTGHTGAVRSVAFSPDGKL 218

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077441 161 IISAAEDKTVRLWDRMTGIEVQRLQFNSNP-NSLEISSDNHIL-TISHGSSISFWEIDTLKKLKEVKVPTN-VASASLHP 237
Cdd:COG2319  219 LASGSADGTVRLWDLATGKLLRTLTGHSGSvRSVAFSPDGRLLaSGSADGTVRLWDLATGELLRTLTGHSGgVNSVAFSP 298

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 161077441 238 DKHVFVCGGEDFKMYKFDYITGNEIESFKGHFGPVHSVKFSPDGELYASGSEDGTLRLWQTTVGK 302
Cdd:COG2319  299 DGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGE 363
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 12-297 3.03e-50

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 168.67  E-value: 3.03e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077441  12 TCSGHTRPVVHLDFSDICDagyFLISACKDGSPMLRHGDTGDWVGTFEGHKGAVWNATLNRNATLAASGAADFTGKVWNA 91
Cdd:cd00200    4 TLKGHTGGVTCVAFSPDGK---LLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077441  92 VTGAEIHSF-QHKHIVKSVAFDRDSENIVTGSNEKLVRVFNLEQPEAQPEeYAGHTGAIKRALFCRGDKCIISAAEDKTV 170
Cdd:cd00200   81 ETGECVRTLtGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTT-LRGHTDWVNSVAFSPDGTFVASSSQDGTI 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077441 171 RLWDRMTGIEVQRLQFNSNP-NSLEISSDN-HILTISHGSSISFWEIDTLKKLKEVKVPTN-VASASLHPDKHVFVCGGE 247
Cdd:cd00200  160 KLWDLRTGKCVATLTGHTGEvNSVAFSPDGeKLLSSSSDGTIKLWDLSTGKCLGTLRGHENgVNSVAFSPDGYLLASGSE 239

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 161077441 248 DFKMYKFDYITGNEIESFKGHFGPVHSVKFSPDGELYASGSEDGTLRLWQ 297
Cdd:cd00200  240 DGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
2-303 3.26e-50

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 172.02  E-value: 3.26e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077441   2 AANNLRQIPLTCSGHTRPVVHLDFSDicdAGYFLISACKDGSPMLRHGDTGDWVGTFEGHKGAVWNATLNRNATLAASGA 81
Cdd:COG2319   21 LAAALGALLLLLLGLAAAVASLAASP---DGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASAS 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077441  82 ADFTGKVWNAVTGAEIHSFQ-HKHIVKSVAFDRDSENIVTGSNEKLVRVFNLEQPEaQPEEYAGHTGAIKRALFCRGDKC 160
Cdd:COG2319   98 ADGTVRLWDLATGLLLRTLTgHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGK-LLRTLTGHSGAVTSVAFSPDGKL 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077441 161 IISAAEDKTVRLWDRMTGIEVQRLQFNSNP-NSLEISSDNHIL-TISHGSSISFWEIDTLKKLKEVKVPTN-VASASLHP 237
Cdd:COG2319  177 LASGSDDGTVRLWDLATGKLLRTLTGHTGAvRSVAFSPDGKLLaSGSADGTVRLWDLATGKLLRTLTGHSGsVRSVAFSP 256

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 161077441 238 DKHVFVCGGEDFKMYKFDYITGNEIESFKGHFGPVHSVKFSPDGELYASGSEDGTLRLWQTTVGKT 303
Cdd:COG2319  257 DGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKL 322
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 55-303 6.33e-44

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 152.10  E-value: 6.33e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077441  55 VGTFEGHKGAVWNATLNRNATLAASGAADFTGKVWNAVTGAEIHSFQ-HKHIVKSVAFDRDSENIVTGSNEKLVRVFNLE 133
Cdd:cd00200    2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKgHTGPVRDVAASADGTYLASGSSDKTIRLWDLE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077441 134 QPEaQPEEYAGHTGAIKRALFCRGDKCIISAAEDKTVRLWDRMTGIEVQRLQFNSNP-NSLEISSDNHILTISHG-SSIS 211
Cdd:cd00200   82 TGE-CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWvNSVAFSPDGTFVASSSQdGTIK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077441 212 FWEIDTLKKLKEVKVPTN-VASASLHPDKHVFVCGGEDFKMYKFDYITGNEIESFKGHFGPVHSVKFSPDGELYASGSED 290
Cdd:cd00200  161 LWDLRTGKCVATLTGHTGeVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSED 240

                        250
                 ....*....|...
gi 161077441 291 GTLRLWQTTVGKT 303
Cdd:cd00200  241 GTIRVWDLRTGEC 253
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 102-306 3.95e-39

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 139.78  E-value: 3.95e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077441 102 HKHIVKSVAFDRDSENIVTGSNEKLVRVFNLEQPEaQPEEYAGHTGAIKRALFCRGDKCIISAAEDKTVRLWDRMTGIEV 181
Cdd:cd00200    8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGE-LLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECV 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077441 182 QRL-QFNSNPNSLEISSDNHILTISHG-SSISFWEIDTLKKLKEVKVPTN-VASASLHPDKHVFVCGGEDFKMYKFDYIT 258
Cdd:cd00200   87 RTLtGHTSYVSSVAFSPDGRILSSSSRdKTIKVWDVETGKCLTTLRGHTDwVNSVAFSPDGTFVASSSQDGTIKLWDLRT 166

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 161077441 259 GNEIESFKGHFGPVHSVKFSPDGELYASGSEDGTLRLWQTTVGKTYGL 306
Cdd:cd00200  167 GKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGT 214
WD40 COG2319
WD40 repeat [General function prediction only];
72-302 8.80e-34

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 128.11  E-value: 8.80e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077441  72 RNATLAASGAADFTGKVWNAVTGAEIHSFQ-HKHIVKSVAFDRDSENIVTGSNEKLVRVfNLEQPEAQPEEYAGHTGAIK 150
Cdd:COG2319    4 ADGAALAAASADLALALLAAALGALLLLLLgLAAAVASLAASPDGARLAAGAGDLTLLL-LDAAAGALLATLLGHTAAVL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077441 151 RALFCRGDKCIISAAEDKTVRLWDRMTGIEVQRLQFNSNP-NSLEISSDNHIL-TISHGSSISFWEIDTLKKLKEVKVPT 228
Cdd:COG2319   83 SVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAvRSVAFSPDGKTLaSGSADGTVRLWDLATGKLLRTLTGHS 162

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 161077441 229 N-VASASLHPDKHVFVCGGEDFKMYKFDYITGNEIESFKGHFGPVHSVKFSPDGELYASGSEDGTLRLWQTTVGK 302
Cdd:COG2319  163 GaVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGK 237
WD40 COG2319
WD40 repeat [General function prediction only];
7-177 2.39e-29

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 116.16  E-value: 2.39e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077441   7 RQIPLTCSGHTRPVVHLDFS-DicdaGYFLISACKDGSPMLRHGDTGDWVGTFEGHKGAVWNATLNRNATLAASGAADFT 85
Cdd:COG2319  236 GKLLRTLTGHSGSVRSVAFSpD----GRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGT 311

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077441  86 GKVWNAVTGAEIHSFQ-HKHIVKSVAFDRDSENIVTGSNEKLVRVFNLEQPEaQPEEYAGHTGAIKRALFCRGDKCIISA 164
Cdd:COG2319  312 VRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGE-LLRTLTGHTGAVTSVAFSPDGRTLASG 390

                        170
                 ....*....|...
gi 161077441 165 AEDKTVRLWDRMT 177
Cdd:COG2319  391 SADGTVRLWDLAT 403
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
157-292 2.40e-10

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 59.71  E-value: 2.40e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077441 157 GDKCIISAAEDKTVRLWDRMTGIEVQRLQFNSNPNSLEISSDNHILTISHGSSISFWEID--TLKKLKEVKVPTNVASAS 234
Cdd:COG3391   79 GRRLYVANSGSGRVSVIDLATGKVVATIPVGGGPRGLAVDPDGGRLYVADSGNGRVSVIDtaTGKVVATIPVGAGPHGIA 158

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 161077441 235 LHPD-KHVFVCGGEDFKM----YKFDYITGNEIESFKGHFGPvHSVKFSPDG-ELYASGSEDGT 292
Cdd:COG3391  159 VDPDgKRLYVANSGSNTVsvivSVIDTATGKVVATIPVGGGP-VGVAVSPDGrRLYVANRGSNT 221
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 258-296 8.76e-10

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 53.47  E-value: 8.76e-10
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 161077441   258 TGNEIESFKGHFGPVHSVKFSPDGELYASGSEDGTLRLW 296
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
259-296 7.33e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 50.81  E-value: 7.33e-09
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 161077441  259 GNEIESFKGHFGPVHSVKFSPDGELYASGSEDGTLRLW 296
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 19-174 1.79e-07

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 52.78  E-value: 1.79e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077441  19 PVVHL----DFSDICDAGYF---LISACKDGSPMLRHGDTGDWVGTFEGHKGAVWNATLNR-NATLAASGAADFTGKVWN 90
Cdd:PLN00181 525 PVVELasrsKLSGICWNSYIksqVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWS 604

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077441  91 AVTGAEIHSFQHKHIVKSVAFDRDS-ENIVTGSNEKLVRVFNLEQPEAQPEEYAGHTGAIKRALFCrGDKCIISAAEDKT 169
Cdd:PLN00181 605 INQGVSIGTIKTKANICCVQFPSESgRSLAFGSADHKVYYYDLRNPKLPLCTMIGHSKTVSYVRFV-DSSTLVSSSTDNT 683


                 ....*
gi 161077441 170 VRLWD 174
Cdd:PLN00181 684 LKLWD 688
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 141-174 1.56e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.45  E-value: 1.56e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 161077441   141 EYAGHTGAIKRALFCRGDKCIISAAEDKTVRLWD 174
Cdd:smart00320   7 TLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
141-174 1.39e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.78  E-value: 1.39e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 161077441  141 EYAGHTGAIKRALFCRGDKCIISAAEDKTVRLWD 174
Cdd:pfam00400   6 TLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 93-131 3.53e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.60  E-value: 3.53e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 161077441    93 TGAEIHSFQ-HKHIVKSVAFDRDSENIVTGSNEKLVRVFN 131
Cdd:smart00320   1 SGELLKTLKgHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
55-90 4.77e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 34.24  E-value: 4.77e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 161077441   55 VGTFEGHKGAVWNATLNRNATLAASGAADFTGKVWN 90
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 51-90 8.91e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 33.44  E-value: 8.91e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 161077441    51 TGDWVGTFEGHKGAVWNATLNRNATLAASGAADFTGKVWN 90
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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