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Conserved domains on  [gi|161076731|ref|NP_001097097|]
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smoke alarm, isoform C [Drosophila melanogaster]

Protein Classification

discoidin domain-containing protein( domain architecture ID 10044135)

discoidin domain-containing protein similar to human retinoschisin (aka X-linked juvenile retinoschisis protein) that plays a crucial role in the cellular organization of the retina

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
FA58C cd00057
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
81-233 1.39e-27

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


:

Pssm-ID: 238014 [Multi-domain]  Cd Length: 143  Bit Score: 108.59  E-value: 1.39e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161076731  81 PLGMESLLiTDAQITASSAhDMAFVGPQHARLktdNDGGAWCPKhmvSNALKEYLQVDLLQTHVITAIRTQGRYGKGQGq 160
Cdd:cd00057    2 PLGMESGL-ADDQITASSS-YSSGWEASRARL---NSDNAWTPA---VNDPPQWLQVDLGKTRRVTGIQTQGRKGGGSS- 72
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 161076731 161 EYTEAYVLEYWRPGfDKWQRWKNIQGKEILPGNINTYSEVENALQPIIFASKIRIYPYGQYDRtVCLRAEIVG 233
Cdd:cd00057   73 EWVTSYKVQYSLDG-ETWTTYKDKGEEKVFTGNSDGSTPVTNDFPPPIVARYIRILPTTWNGN-ISLRLELYG 143
 
Name Accession Description Interval E-value
FA58C cd00057
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
81-233 1.39e-27

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 238014 [Multi-domain]  Cd Length: 143  Bit Score: 108.59  E-value: 1.39e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161076731  81 PLGMESLLiTDAQITASSAhDMAFVGPQHARLktdNDGGAWCPKhmvSNALKEYLQVDLLQTHVITAIRTQGRYGKGQGq 160
Cdd:cd00057    2 PLGMESGL-ADDQITASSS-YSSGWEASRARL---NSDNAWTPA---VNDPPQWLQVDLGKTRRVTGIQTQGRKGGGSS- 72
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 161076731 161 EYTEAYVLEYWRPGfDKWQRWKNIQGKEILPGNINTYSEVENALQPIIFASKIRIYPYGQYDRtVCLRAEIVG 233
Cdd:cd00057   73 EWVTSYKVQYSLDG-ETWTTYKDKGEEKVFTGNSDGSTPVTNDFPPPIVARYIRILPTTWNGN-ISLRLELYG 143
FA58C smart00231
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
78-234 5.97e-22

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 214572  Cd Length: 139  Bit Score: 92.57  E-value: 5.97e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161076731    78 CNVPLGMESllitDAQITASSAhdmaFVGPQHARLkTDNDGGAWCPKHmvsNALKEYLQVDLLQTHVITAIRTQGRYGKG 157
Cdd:smart00231   2 CNEPLGLES----DSQITASSS----YWAAKIARL-NGGSDGGWCPAK---NDLPPWIQVDLGRLRTVTGVITGRRHGNG 69
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 161076731   158 QGQEYTEAYVLEywrpgfdkWQRWKNIQGKE--ILPGNINTYSEVENALQPIIFASKIRIYPYGQYdRTVCLRAEIVGC 234
Cdd:smart00231  70 DWVTYKLEYSDD--------GVNWTTYKDGNskVFPGNSDAGTVVLNDFPPPIVARYVRILPTGWN-GNIILRVELLGC 139
F5_F8_type_C pfam00754
F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.
93-231 7.50e-17

F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.


Pssm-ID: 459925 [Multi-domain]  Cd Length: 127  Bit Score: 77.49  E-value: 7.50e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161076731   93 QITASSAHDmafvGPQHARLKTD-NDGGAWCPKhmvSNALKEYLQVDLLQTHVITAIRTQGRYGKGQGqeYTEAYVLEYW 171
Cdd:pfam00754   1 QITASSSYS----GEGPAAAALDgDPNTAWSAW---SGDDPQWIQVDLGKPKKITGVVTQGRQDGSNG--YVTSYKIEYS 71
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 161076731  172 RPGfdkwQRWKNIQGKEIlPGNINTYSEVENALQPIIFASKIRIYPYGQYDRT-VCLRAEI 231
Cdd:pfam00754  72 LDG----ENWTTVKDEKI-PGNNDNNTPVTNTFDPPIKARYVRIVPTSWNGGNgIALRAEL 127
 
Name Accession Description Interval E-value
FA58C cd00057
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
81-233 1.39e-27

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 238014 [Multi-domain]  Cd Length: 143  Bit Score: 108.59  E-value: 1.39e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161076731  81 PLGMESLLiTDAQITASSAhDMAFVGPQHARLktdNDGGAWCPKhmvSNALKEYLQVDLLQTHVITAIRTQGRYGKGQGq 160
Cdd:cd00057    2 PLGMESGL-ADDQITASSS-YSSGWEASRARL---NSDNAWTPA---VNDPPQWLQVDLGKTRRVTGIQTQGRKGGGSS- 72
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 161076731 161 EYTEAYVLEYWRPGfDKWQRWKNIQGKEILPGNINTYSEVENALQPIIFASKIRIYPYGQYDRtVCLRAEIVG 233
Cdd:cd00057   73 EWVTSYKVQYSLDG-ETWTTYKDKGEEKVFTGNSDGSTPVTNDFPPPIVARYIRILPTTWNGN-ISLRLELYG 143
FA58C smart00231
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
78-234 5.97e-22

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 214572  Cd Length: 139  Bit Score: 92.57  E-value: 5.97e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161076731    78 CNVPLGMESllitDAQITASSAhdmaFVGPQHARLkTDNDGGAWCPKHmvsNALKEYLQVDLLQTHVITAIRTQGRYGKG 157
Cdd:smart00231   2 CNEPLGLES----DSQITASSS----YWAAKIARL-NGGSDGGWCPAK---NDLPPWIQVDLGRLRTVTGVITGRRHGNG 69
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 161076731   158 QGQEYTEAYVLEywrpgfdkWQRWKNIQGKE--ILPGNINTYSEVENALQPIIFASKIRIYPYGQYdRTVCLRAEIVGC 234
Cdd:smart00231  70 DWVTYKLEYSDD--------GVNWTTYKDGNskVFPGNSDAGTVVLNDFPPPIVARYVRILPTGWN-GNIILRVELLGC 139
F5_F8_type_C pfam00754
F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.
93-231 7.50e-17

F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.


Pssm-ID: 459925 [Multi-domain]  Cd Length: 127  Bit Score: 77.49  E-value: 7.50e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161076731   93 QITASSAHDmafvGPQHARLKTD-NDGGAWCPKhmvSNALKEYLQVDLLQTHVITAIRTQGRYGKGQGqeYTEAYVLEYW 171
Cdd:pfam00754   1 QITASSSYS----GEGPAAAALDgDPNTAWSAW---SGDDPQWIQVDLGKPKKITGVVTQGRQDGSNG--YVTSYKIEYS 71
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 161076731  172 RPGfdkwQRWKNIQGKEIlPGNINTYSEVENALQPIIFASKIRIYPYGQYDRT-VCLRAEI 231
Cdd:pfam00754  72 LDG----ENWTTVKDEKI-PGNNDNNTPVTNTFDPPIKARYVRIVPTSWNGGNgIALRAEL 127
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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