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Conserved domains on  [gi|357197126|ref|NP_001095056|]
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sulfotransferase family 2A member 1 family member [Mus musculus]

Protein Classification

sulfotransferase domain-containing protein( domain architecture ID 10464534)

sulfotransferase domain-containing protein such as mammalian sulfotransferases that utilize 3'-phospho-5'-adenylyl sulfate (PAPS) as the sulfonate donor to catalyze the sulfate conjugation of a variety of substrates including catecholamines, phenolic drugs, neurotransmitters, heparan, and estrogen, among others

CATH:  3.40.50.300
EC:  2.8.2.-
Gene Ontology:  GO:0008146
PubMed:  9360604|31270211
SCOP:  4003933

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
34-278 3.78e-99

Sulfotransferase domain;


:

Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 290.78  E-value: 3.78e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357197126   34 EEDLLILTYPKSGTHWLIEIVCLIQTRGDPKWIQTVPI---WDRSPWLE---------TDIGYLALINKEGPRLISSHLP 101
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEKSEEPHLfnnHNRSPFLEwypgdtyfdVAEGPVRLNALPSPRIIKTHLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357197126  102 VHLFFKSFFSSKAKAIYLIRNPRDILVSGYFFYGNTNLVKNPGSLRTYFEWFLKGNVIYGSWFEHVRGWLSMREWDNFLV 181
Cdd:pfam00685  81 LHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGWWKLRPPGNILF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357197126  182 LYYEDMKKDTKGTIKKICDFLGKKLEPDELDLVLKYSSFQAMKENNMSNYSLVSEDMItnglKLMRKGTTGDWKNHFTVA 261
Cdd:pfam00685 161 LRYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENMKGNPCLNYSKLPKEVS----PFFRKGLVGDWKNYFTPE 236

                         250
                  ....*....|....*..
gi 357197126  262 QAEAFNKVFQEKMAGFP 278
Cdd:pfam00685 237 QAEKFDEIYQEKMKGTG 253
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
34-278 3.78e-99

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 290.78  E-value: 3.78e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357197126   34 EEDLLILTYPKSGTHWLIEIVCLIQTRGDPKWIQTVPI---WDRSPWLE---------TDIGYLALINKEGPRLISSHLP 101
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEKSEEPHLfnnHNRSPFLEwypgdtyfdVAEGPVRLNALPSPRIIKTHLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357197126  102 VHLFFKSFFSSKAKAIYLIRNPRDILVSGYFFYGNTNLVKNPGSLRTYFEWFLKGNVIYGSWFEHVRGWLSMREWDNFLV 181
Cdd:pfam00685  81 LHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGWWKLRPPGNILF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357197126  182 LYYEDMKKDTKGTIKKICDFLGKKLEPDELDLVLKYSSFQAMKENNMSNYSLVSEDMItnglKLMRKGTTGDWKNHFTVA 261
Cdd:pfam00685 161 LRYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENMKGNPCLNYSKLPKEVS----PFFRKGLVGDWKNYFTPE 236

                         250
                  ....*....|....*..
gi 357197126  262 QAEAFNKVFQEKMAGFP 278
Cdd:pfam00685 237 QAEKFDEIYQEKMKGTG 253
PLN02164 PLN02164
sulfotransferase
 30-276 1.24e-23

sulfotransferase


Pssm-ID: 177822  Cd Length: 346  Bit Score: 98.45  E-value: 1.24e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357197126  30 FVVKEEDLLILTYPKSGTHWLIEIVCLIQTRGDPKwIQTVPIWDRSP-----WLETDIGYLA---LINKEGPRLISSHLP 101
Cdd:PLN02164  75 FQARPNDFLVCSYPKTGTTWLKALTFAIANRSRFD-DSSNPLLKRNPhefvpYIEIDFPFFPsvdVLKDKGNTLFSTHIP 153

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357197126 102 VHLFFKSFFSSKAKAIYLIRNPRDILVSGYFFYGNTNLVKNP-GSLRTYFEWFLKGNVIYGSWFEHVRG-WLSMRE-WDN 178
Cdd:PLN02164 154 YGLLPDSVVKSGCKMVYIWRDPKDTFISMWTFLHKERSQQGPlNSLEESFDMFCRGLSVYGPYLDHVLGyWKAYQEnPDR 233

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357197126 179 FLVLYYEDMKKDTKGTIKKICDFLGKKLEPDE-----LDLVLKYSSFQAMKENNMSNYSLVSEDM--ITNGLKLMRKGTT 251
Cdd:PLN02164 234 ILFLKYETMRADPLPYVKRLAEFMGYGFTAEEeekgvVEKVVKLCSFETLKNLEANKGEKDREDRpaVYANSAYFRKGKV 313

                        250       260
                 ....*....|....*....|....*
gi 357197126 252 GDWKNHFTVAQAEAFNKVFQEKMAG 276
Cdd:PLN02164 314 GDWQNYLTPEMAARIDGLMEEKFKG 338
LpsS COG4424
LPS sulfotransferase NodH [Cell wall/membrane/envelope biogenesis];
38-216 7.87e-07

LPS sulfotransferase NodH [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443539  Cd Length: 238  Bit Score: 48.86  E-value: 7.87e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357197126  38 LILTYPKSGTHWLIEivCLIQTR--GDPK-WIQT--VPIW-DRSPWLETDIGYLALINKE-----------GPRLISSHL 100
Cdd:COG4424   10 VICATPRSGSTLLCE--LLNATGvaGCPGeYFNPpfIPEWaRGFLLGDRDRDPDEYLRAIrragttpngvfGFKLFWDQL 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357197126 101 PV-----HLFFKSFfsSKAKAIYLIRnpRDIL---VSGYF------FYGNTNLVKNPGSLRTY-FEWFLKgnviygsWFE 165
Cdd:COG4424   88 PRllqraLRLLAAF--PDLKFIHLTR--RDKLaqaVSLVIaqqtgqWHSDADDALAPTAPPEYdAEEIAR-------LLE 156

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 357197126 166 HVRGWlsMREWDNF--------LVLYYEDMKKDTKGTIKKICDFLGKKLEPDELDLVLK 216
Cdd:COG4424  157 ALQDF--EARWEAWfartgitpLEITYEDLAADPVEVLNRVLDFLGVDPPLAPLRPALK 213
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
34-278 3.78e-99

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 290.78  E-value: 3.78e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357197126   34 EEDLLILTYPKSGTHWLIEIVCLIQTRGDPKWIQTVPI---WDRSPWLE---------TDIGYLALINKEGPRLISSHLP 101
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEKSEEPHLfnnHNRSPFLEwypgdtyfdVAEGPVRLNALPSPRIIKTHLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357197126  102 VHLFFKSFFSSKAKAIYLIRNPRDILVSGYFFYGNTNLVKNPGSLRTYFEWFLKGNVIYGSWFEHVRGWLSMREWDNFLV 181
Cdd:pfam00685  81 LHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGWWKLRPPGNILF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357197126  182 LYYEDMKKDTKGTIKKICDFLGKKLEPDELDLVLKYSSFQAMKENNMSNYSLVSEDMItnglKLMRKGTTGDWKNHFTVA 261
Cdd:pfam00685 161 LRYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENMKGNPCLNYSKLPKEVS----PFFRKGLVGDWKNYFTPE 236

                         250
                  ....*....|....*..
gi 357197126  262 QAEAFNKVFQEKMAGFP 278
Cdd:pfam00685 237 QAEKFDEIYQEKMKGTG 253
PLN02164 PLN02164
sulfotransferase
 30-276 1.24e-23

sulfotransferase


Pssm-ID: 177822  Cd Length: 346  Bit Score: 98.45  E-value: 1.24e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357197126  30 FVVKEEDLLILTYPKSGTHWLIEIVCLIQTRGDPKwIQTVPIWDRSP-----WLETDIGYLA---LINKEGPRLISSHLP 101
Cdd:PLN02164  75 FQARPNDFLVCSYPKTGTTWLKALTFAIANRSRFD-DSSNPLLKRNPhefvpYIEIDFPFFPsvdVLKDKGNTLFSTHIP 153

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357197126 102 VHLFFKSFFSSKAKAIYLIRNPRDILVSGYFFYGNTNLVKNP-GSLRTYFEWFLKGNVIYGSWFEHVRG-WLSMRE-WDN 178
Cdd:PLN02164 154 YGLLPDSVVKSGCKMVYIWRDPKDTFISMWTFLHKERSQQGPlNSLEESFDMFCRGLSVYGPYLDHVLGyWKAYQEnPDR 233

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357197126 179 FLVLYYEDMKKDTKGTIKKICDFLGKKLEPDE-----LDLVLKYSSFQAMKENNMSNYSLVSEDM--ITNGLKLMRKGTT 251
Cdd:PLN02164 234 ILFLKYETMRADPLPYVKRLAEFMGYGFTAEEeekgvVEKVVKLCSFETLKNLEANKGEKDREDRpaVYANSAYFRKGKV 313

                        250       260
                 ....*....|....*....|....*
gi 357197126 252 GDWKNHFTVAQAEAFNKVFQEKMAG 276
Cdd:PLN02164 314 GDWQNYLTPEMAARIDGLMEEKFKG 338
Sulfotransfer_3 pfam13469
Sulfotransferase family;
43-203 1.24e-09

Sulfotransferase family;


Pssm-ID: 463887  Cd Length: 173  Bit Score: 56.14  E-value: 1.24e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357197126   43 PKSGTHWLIEIVCLI-QTRGDPKWIQTVPIWDRSPWLETDIGYLALINKEGPRLISSHLPVHLFF----KSFFSsKAKAI 117
Cdd:pfam13469   7 PRSGTTLLHRLLAAHpDVRPPEETWFVIPRILALLQAWGKSLEALARVPSYARWLCDKSPSHLFHldllLKAFP-DAKFI 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357197126  118 YLIRNPRDILVSGY--FFYGNTNlvknpgSLRTYFEWFLKGNVIYgsWFEHVRGWlsMREW-----DNFLVLYYEDMKKD 190
Cdd:pfam13469  86 HLHRDPVDTVISSYcsLFGFTLS------SYSTAFLRDIGLALAR--WSRAYERL--MAARarvppGRFLDVRYEDLVAD 155

                         170
                  ....*....|...
gi 357197126  191 TKGTIKKICDFLG 203
Cdd:pfam13469 156 PEGTLRRILEFLG 168
LpsS COG4424
LPS sulfotransferase NodH [Cell wall/membrane/envelope biogenesis];
38-216 7.87e-07

LPS sulfotransferase NodH [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443539  Cd Length: 238  Bit Score: 48.86  E-value: 7.87e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357197126  38 LILTYPKSGTHWLIEivCLIQTR--GDPK-WIQT--VPIW-DRSPWLETDIGYLALINKE-----------GPRLISSHL 100
Cdd:COG4424   10 VICATPRSGSTLLCE--LLNATGvaGCPGeYFNPpfIPEWaRGFLLGDRDRDPDEYLRAIrragttpngvfGFKLFWDQL 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357197126 101 PV-----HLFFKSFfsSKAKAIYLIRnpRDIL---VSGYF------FYGNTNLVKNPGSLRTY-FEWFLKgnviygsWFE 165
Cdd:COG4424   88 PRllqraLRLLAAF--PDLKFIHLTR--RDKLaqaVSLVIaqqtgqWHSDADDALAPTAPPEYdAEEIAR-------LLE 156

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 357197126 166 HVRGWlsMREWDNF--------LVLYYEDMKKDTKGTIKKICDFLGKKLEPDELDLVLK 216
Cdd:COG4424  157 ALQDF--EARWEAWfartgitpLEITYEDLAADPVEVLNRVLDFLGVDPPLAPLRPALK 213
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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