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Conserved domains on  [gi|168823480|ref|NP_001095004|]
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sulfotransferase family member-like [Mus musculus]

Protein Classification

sulfotransferase domain-containing protein( domain architecture ID 10464534)

sulfotransferase domain-containing protein such as mammalian sulfotransferases that utilize 3'-phospho-5'-adenylyl sulfate (PAPS) as the sulfonate donor to catalyze the sulfate conjugation of a variety of substrates including catecholamines, phenolic drugs, neurotransmitters, heparan, and estrogen, among others

CATH:  3.40.50.300
EC:  2.8.2.-
Gene Ontology:  GO:0008146
PubMed:  9360604|31270211
SCOP:  4003933

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
33-277 7.75e-98

Sulfotransferase domain;


:

Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 287.70  E-value: 7.75e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168823480   33 EEDLLILTYPKSGTNWLIEIVCLIQTKGDSKWIQTVSI---QDRSPWLE---------TNRGYPALINKQGPRLITSHLP 100
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEKSEEPHLfnnHNRSPFLEwypgdtyfdVAEGPVRLNALPSPRIIKTHLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168823480  101 IHLFSKSFFSSKAKAIYLIRNPRDILLSGYFFWGNTNLVKNPGSLRTYFEWFLKGNVIYGSWFEHVCGWLSMREWDNFLV 180
Cdd:pfam00685  81 LHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGWWKLRPPGNILF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168823480  181 LYYEDMKKDTKGTIKKICDFLGKKLEPDELDLVLKYSSFQAMKENNMSNYSLVSEDIitngFKLMRKGTTGDWKNHFTVA 260
Cdd:pfam00685 161 LRYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENMKGNPCLNYSKLPKEV----SPFFRKGLVGDWKNYFTPE 236

                         250
                  ....*....|....*..
gi 168823480  261 QAEAFDKVFQEKMAGFP 277
Cdd:pfam00685 237 QAEKFDEIYQEKMKGTG 253
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
33-277 7.75e-98

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 287.70  E-value: 7.75e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168823480   33 EEDLLILTYPKSGTNWLIEIVCLIQTKGDSKWIQTVSI---QDRSPWLE---------TNRGYPALINKQGPRLITSHLP 100
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEKSEEPHLfnnHNRSPFLEwypgdtyfdVAEGPVRLNALPSPRIIKTHLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168823480  101 IHLFSKSFFSSKAKAIYLIRNPRDILLSGYFFWGNTNLVKNPGSLRTYFEWFLKGNVIYGSWFEHVCGWLSMREWDNFLV 180
Cdd:pfam00685  81 LHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGWWKLRPPGNILF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168823480  181 LYYEDMKKDTKGTIKKICDFLGKKLEPDELDLVLKYSSFQAMKENNMSNYSLVSEDIitngFKLMRKGTTGDWKNHFTVA 260
Cdd:pfam00685 161 LRYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENMKGNPCLNYSKLPKEV----SPFFRKGLVGDWKNYFTPE 236

                         250
                  ....*....|....*..
gi 168823480  261 QAEAFDKVFQEKMAGFP 277
Cdd:pfam00685 237 QAEKFDEIYQEKMKGTG 253
PLN02164 PLN02164
sulfotransferase
 29-275 4.00e-22

sulfotransferase


Pssm-ID: 177822  Cd Length: 346  Bit Score: 94.22  E-value: 4.00e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168823480  29 FVVKEEDLLILTYPKSGTNWLIEIVCLI--QTKGD--SKWIQTVSIQDRSPWLETNRG-YPAL--INKQGPRLITSHLPI 101
Cdd:PLN02164  75 FQARPNDFLVCSYPKTGTTWLKALTFAIanRSRFDdsSNPLLKRNPHEFVPYIEIDFPfFPSVdvLKDKGNTLFSTHIPY 154

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168823480 102 HLFSKSFFSSKAKAIYLIRNPRDILLSGYFFWGNTNLVKNP-GSLRTYFEWFLKGNVIYGSWFEHVCG-WLSMRE-WDNF 178
Cdd:PLN02164 155 GLLPDSVVKSGCKMVYIWRDPKDTFISMWTFLHKERSQQGPlNSLEESFDMFCRGLSVYGPYLDHVLGyWKAYQEnPDRI 234

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168823480 179 LVLYYEDMKKDTKGTIKKICDFLGKKLEPDE-----LDLVLKYSSFQAMKENNMSNYSLVSEDI--ITNGFKLMRKGTTG 251
Cdd:PLN02164 235 LFLKYETMRADPLPYVKRLAEFMGYGFTAEEeekgvVEKVVKLCSFETLKNLEANKGEKDREDRpaVYANSAYFRKGKVG 314

                        250       260
                 ....*....|....*....|....
gi 168823480 252 DWKNHFTVAQAEAFDKVFQEKMAG 275
Cdd:PLN02164 315 DWQNYLTPEMAARIDGLMEEKFKG 338
LpsS COG4424
LPS sulfotransferase NodH [Cell wall/membrane/envelope biogenesis];
37-215 3.72e-05

LPS sulfotransferase NodH [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443539  Cd Length: 238  Bit Score: 43.85  E-value: 3.72e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168823480  37 LILTYPKSGTNWLIEivCLIQTK--GDSK-WIQTVSI---QDRSPWLETNRGYPALINKQ-----------GPRLITSHL 99
Cdd:COG4424   10 VICATPRSGSTLLCE--LLNATGvaGCPGeYFNPPFIpewARGFLLGDRDRDPDEYLRAIrragttpngvfGFKLFWDQL 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168823480 100 P-----IHLFSKSFfsSKAKAIYLIRnpRDIL---LSGYF------FWGNTNLVKNPGSLRTY-FEWFLKgnviygsWFE 164
Cdd:COG4424   88 PrllqrALRLLAAF--PDLKFIHLTR--RDKLaqaVSLVIaqqtgqWHSDADDALAPTAPPEYdAEEIAR-------LLE 156

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 168823480 165 HVCGWlsMREWDNF--------LVLYYEDMKKDTKGTIKKICDFLGKKLEPDELDLVLK 215
Cdd:COG4424  157 ALQDF--EARWEAWfartgitpLEITYEDLAADPVEVLNRVLDFLGVDPPLAPLRPALK 213
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
33-277 7.75e-98

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 287.70  E-value: 7.75e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168823480   33 EEDLLILTYPKSGTNWLIEIVCLIQTKGDSKWIQTVSI---QDRSPWLE---------TNRGYPALINKQGPRLITSHLP 100
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEKSEEPHLfnnHNRSPFLEwypgdtyfdVAEGPVRLNALPSPRIIKTHLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168823480  101 IHLFSKSFFSSKAKAIYLIRNPRDILLSGYFFWGNTNLVKNPGSLRTYFEWFLKGNVIYGSWFEHVCGWLSMREWDNFLV 180
Cdd:pfam00685  81 LHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGWWKLRPPGNILF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168823480  181 LYYEDMKKDTKGTIKKICDFLGKKLEPDELDLVLKYSSFQAMKENNMSNYSLVSEDIitngFKLMRKGTTGDWKNHFTVA 260
Cdd:pfam00685 161 LRYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENMKGNPCLNYSKLPKEV----SPFFRKGLVGDWKNYFTPE 236

                         250
                  ....*....|....*..
gi 168823480  261 QAEAFDKVFQEKMAGFP 277
Cdd:pfam00685 237 QAEKFDEIYQEKMKGTG 253
PLN02164 PLN02164
sulfotransferase
 29-275 4.00e-22

sulfotransferase


Pssm-ID: 177822  Cd Length: 346  Bit Score: 94.22  E-value: 4.00e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168823480  29 FVVKEEDLLILTYPKSGTNWLIEIVCLI--QTKGD--SKWIQTVSIQDRSPWLETNRG-YPAL--INKQGPRLITSHLPI 101
Cdd:PLN02164  75 FQARPNDFLVCSYPKTGTTWLKALTFAIanRSRFDdsSNPLLKRNPHEFVPYIEIDFPfFPSVdvLKDKGNTLFSTHIPY 154

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168823480 102 HLFSKSFFSSKAKAIYLIRNPRDILLSGYFFWGNTNLVKNP-GSLRTYFEWFLKGNVIYGSWFEHVCG-WLSMRE-WDNF 178
Cdd:PLN02164 155 GLLPDSVVKSGCKMVYIWRDPKDTFISMWTFLHKERSQQGPlNSLEESFDMFCRGLSVYGPYLDHVLGyWKAYQEnPDRI 234

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168823480 179 LVLYYEDMKKDTKGTIKKICDFLGKKLEPDE-----LDLVLKYSSFQAMKENNMSNYSLVSEDI--ITNGFKLMRKGTTG 251
Cdd:PLN02164 235 LFLKYETMRADPLPYVKRLAEFMGYGFTAEEeekgvVEKVVKLCSFETLKNLEANKGEKDREDRpaVYANSAYFRKGKVG 314

                        250       260
                 ....*....|....*....|....
gi 168823480 252 DWKNHFTVAQAEAFDKVFQEKMAG 275
Cdd:PLN02164 315 DWQNYLTPEMAARIDGLMEEKFKG 338
Sulfotransfer_3 pfam13469
Sulfotransferase family;
36-202 8.35e-10

Sulfotransferase family;


Pssm-ID: 463887  Cd Length: 173  Bit Score: 56.53  E-value: 8.35e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168823480   36 LLILTYPKSGTNWLIEIVCL---IQTKGDSKWIQTVSIQDRSPWletNRGYPALINKQGP-RLITSHLPIHLFS----KS 107
Cdd:pfam13469   1 IFIVGLPRSGTTLLHRLLAAhpdVRPPEETWFVIPRILALLQAW---GKSLEALARVPSYaRWLCDKSPSHLFHldllLK 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168823480  108 FFSsKAKAIYLIRNPRDILLSGYF-FWGNTNlvknpGSLRTYFEWFLKGNVIYgsWFEHVCGWlsMREW-----DNFLVL 181
Cdd:pfam13469  78 AFP-DAKFIHLHRDPVDTVISSYCsLFGFTL-----SSYSTAFLRDIGLALAR--WSRAYERL--MAARarvppGRFLDV 147

                         170       180
                  ....*....|....*....|.
gi 168823480  182 YYEDMKKDTKGTIKKICDFLG 202
Cdd:pfam13469 148 RYEDLVADPEGTLRRILEFLG 168
LpsS COG4424
LPS sulfotransferase NodH [Cell wall/membrane/envelope biogenesis];
37-215 3.72e-05

LPS sulfotransferase NodH [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443539  Cd Length: 238  Bit Score: 43.85  E-value: 3.72e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168823480  37 LILTYPKSGTNWLIEivCLIQTK--GDSK-WIQTVSI---QDRSPWLETNRGYPALINKQ-----------GPRLITSHL 99
Cdd:COG4424   10 VICATPRSGSTLLCE--LLNATGvaGCPGeYFNPPFIpewARGFLLGDRDRDPDEYLRAIrragttpngvfGFKLFWDQL 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168823480 100 P-----IHLFSKSFfsSKAKAIYLIRnpRDIL---LSGYF------FWGNTNLVKNPGSLRTY-FEWFLKgnviygsWFE 164
Cdd:COG4424   88 PrllqrALRLLAAF--PDLKFIHLTR--RDKLaqaVSLVIaqqtgqWHSDADDALAPTAPPEYdAEEIAR-------LLE 156

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 168823480 165 HVCGWlsMREWDNF--------LVLYYEDMKKDTKGTIKKICDFLGKKLEPDELDLVLK 215
Cdd:COG4424  157 ALQDF--EARWEAWfartgitpLEITYEDLAADPVEVLNRVLDFLGVDPPLAPLRPALK 213
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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