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Conserved domains on  [gi|148229403|ref|NP_001091580|]
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protocadherin-12 precursor [Bos taurus]

Protein Classification

protocadherin( domain architecture ID 13228088)

protocadherin may have tightly regulated functions in the development, regionalization, and functional differentiation of the central nervous system

CATH:  2.60.40.60
Gene Ontology:  GO:0007156|GO:0005509
PubMed:  28268172|18430161
SCOP:  4007535

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 250-347 3.62e-31

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 117.80  E-value: 3.62e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148229403  250 LEIQEDAAPGTLLINLTATDPDQGPNGEVEYFLSKHVPLEVlntFNIDAKTGQVTLLQHLDYEKNPAYEVDVQARDLGPN 329
Cdd:cd11304     4 VSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGL---FSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|....*...
gi 148229403  330 PIPAHCKILIKVLDVNDN 347
Cdd:cd11304    81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 464-560 7.44e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 97.00  E-value: 7.44e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148229403  464 YQVSTRENNLPSLHLITIKAHDADLGVNGKISYRIQDSPVAHLVAIDSDTGEVTAQRSLDYEQMASFEFLVIAEDSGQPQ 543
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                          90
                  ....*....|....*..
gi 148229403  544 LSSSVSVWVSLLDANDN 560
Cdd:cd11304    82 LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 138-239 8.36e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 93.92  E-value: 8.36e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148229403  138 EQELEISESASLRTRIPLDRALDPDTGPNTLHSYTLS---PSEHFALDVIVGpdqtkhaELVVVKELDREIHSYFDLVLT 214
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsgnEDGLFSIDPSTG-------EITTAKPLDREEQSSYTLTVT 73

                          90       100
                  ....*....|....*....|....*
gi 148229403  215 AYDSGNPPKSGTSLVKVSVLDSNDN 239
Cdd:cd11304    74 ATDGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 362-455 2.37e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 92.76  E-value: 2.37e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148229403  362 VSEALPKDSFIALIMANDLDSGNNGLVHCWLSQ--ELGHFRLKRTNGNtymLLTNATLDREQWPQYTLTLLAQDQGPQPL 439
Cdd:cd11304     6 VPENAPPGTVVLTVSATDPDSGENGEVTYSIVSgnEDGLFSIDPSTGE---ITTAKPLDREEQSSYTLTVTATDGGGPPL 82

                          90
                  ....*....|....*.
gi 148229403  440 SDKKQLSIQISDANDN 455
Cdd:cd11304    83 SSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 616-692 1.43e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 70.42  E-value: 1.43e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148229403  616 LLVTIIARDADSGANGELLYTIRSGNEAGVFVLSPNLGQLFINvtnaSSL---TGSEWELEIVVEDRGSPSLQTRALLQV 692
Cdd:cd11304    15 VVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTA----KPLdreEQSSYTLTVTATDGGGPPLSSTATVTI 90
Cadherin_2 super family cl29227
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 30-110 1.29e-11

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


The actual alignment was detected with superfamily member pfam08266:

Pssm-ID: 462413  Cd Length: 83  Bit Score: 61.39  E-value: 1.29e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148229403    30 TVRYQVAEEVPSGTVIGKLPQERGREeePGQ-AGAAFQVLQLPQGLPIQVDSEDGVLSTGRRLDREQLCRQQDPCLVSFD 108
Cdd:pfam08266    1 QIRYSVPEETERGSFVGNLAKDLGLE--VGElAARGARVVSKGNKQYFQLNPETGDLLLNEKLDREELCGSTEPCVLHFQ 78


                   ..
gi 148229403   109 VL 110
Cdd:pfam08266   79 VL 80
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 250-347 3.62e-31

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 117.80  E-value: 3.62e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148229403  250 LEIQEDAAPGTLLINLTATDPDQGPNGEVEYFLSKHVPLEVlntFNIDAKTGQVTLLQHLDYEKNPAYEVDVQARDLGPN 329
Cdd:cd11304     4 VSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGL---FSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|....*...
gi 148229403  330 PIPAHCKILIKVLDVNDN 347
Cdd:cd11304    81 PLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 266-349 6.06e-24

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 96.65  E-value: 6.06e-24
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148229403    266 TATDPDQGPNGEVEYFLskhVPLEVLNTFNIDAKTGQVTLLQHLDYEKNPAYEVDVQARDLGPNPIPAHCKILIKVLDVN 345
Cdd:smart00112    1 SATDADSGENGKVTYSI---LSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                    ....
gi 148229403    346 DNAP 349
Cdd:smart00112   78 DNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 464-560 7.44e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 97.00  E-value: 7.44e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148229403  464 YQVSTRENNLPSLHLITIKAHDADLGVNGKISYRIQDSPVAHLVAIDSDTGEVTAQRSLDYEQMASFEFLVIAEDSGQPQ 543
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                          90
                  ....*....|....*..
gi 148229403  544 LSSSVSVWVSLLDANDN 560
Cdd:cd11304    82 LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 138-239 8.36e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 93.92  E-value: 8.36e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148229403  138 EQELEISESASLRTRIPLDRALDPDTGPNTLHSYTLS---PSEHFALDVIVGpdqtkhaELVVVKELDREIHSYFDLVLT 214
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsgnEDGLFSIDPSTG-------EITTAKPLDREEQSSYTLTVT 73

                          90       100
                  ....*....|....*....|....*
gi 148229403  215 AYDSGNPPKSGTSLVKVSVLDSNDN 239
Cdd:cd11304    74 ATDGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 362-455 2.37e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 92.76  E-value: 2.37e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148229403  362 VSEALPKDSFIALIMANDLDSGNNGLVHCWLSQ--ELGHFRLKRTNGNtymLLTNATLDREQWPQYTLTLLAQDQGPQPL 439
Cdd:cd11304     6 VPENAPPGTVVLTVSATDPDSGENGEVTYSIVSgnEDGLFSIDPSTGE---ITTAKPLDREEQSSYTLTVTATDGGGPPL 82

                          90
                  ....*....|....*.
gi 148229403  440 SDKKQLSIQISDANDN 455
Cdd:cd11304    83 SSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 482-562 1.02e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 84.71  E-value: 1.02e-19
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148229403    482 KAHDADLGVNGKISYRIQDSPVAHLVAIDSDTGEVTAQRSLDYEQMASFEFLVIAEDSGQPQLSSSVSVWVSLLDANDNA 561
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 148229403    562 P 562
Cdd:smart00112   81 P 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 377-457 3.25e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 83.17  E-value: 3.25e-19
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148229403    377 ANDLDSGNNGLVHCWLSQ--ELGHFRLKRTNGntyMLLTNATLDREQWPQYTLTLLAQDQGPQPLSDKKQLSIQISDAND 454
Cdd:smart00112    2 ATDADSGENGKVTYSILSgnDDGLFSIDPETG---EITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVND 78


                    ...
gi 148229403    455 NAP 457
Cdd:smart00112   79 NAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 157-241 1.59e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 81.24  E-value: 1.59e-18
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148229403    157 RALDPDTGPNTLHSYTLSPSE---HFALDVIVGpdqtkhaELVVVKELDREIHSYFDLVLTAYDSGNPPKSGTSLVKVSV 233
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNddgLFSIDPETG-------EITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITV 73


                    ....*...
gi 148229403    234 LDSNDNSP 241
Cdd:smart00112   74 LDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
251-342 1.70e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 81.58  E-value: 1.70e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148229403   251 EIQEDAAPGTLLINLTATDPDQGPNGEVEYFLSKHvplEVLNTFNIDAKTGQVTLLQHLDYEKNPAYEVDVQARDLGPNP 330
Cdd:pfam00028    4 SVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGG---GPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|..
gi 148229403   331 IPAHCKILIKVL 342
Cdd:pfam00028   81 LSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
464-542 3.82e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 80.42  E-value: 3.82e-18
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 148229403   464 YQVSTRENNLPSLHLITIKAHDADLGVNGKISYRIQDSPVAHLVAIDSDTGEVTAQRSLDYEQMASFEFLVIAEDSGQP 542
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGP 79
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 616-692 1.43e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 70.42  E-value: 1.43e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148229403  616 LLVTIIARDADSGANGELLYTIRSGNEAGVFVLSPNLGQLFINvtnaSSL---TGSEWELEIVVEDRGSPSLQTRALLQV 692
Cdd:cd11304    15 VVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTA----KPLdreEQSSYTLTVTATDGGGPPLSSTATVTI 90
Cadherin pfam00028
Cadherin domain;
362-449 3.31e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 63.47  E-value: 3.31e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148229403   362 VSEALPKDSFIALIMANDLDSGNNGLVHCWLSQ--ELGHFRLKRTNGntyMLLTNATLDREQWPQYTLTLLAQDQGPQPL 439
Cdd:pfam00028    5 VPENAPVGTEVLTVTATDPDLGPNGRIFYSILGggPGGNFRIDPDTG---DISTTKPLDRESIGEYELTVEATDSGGPPL 81

                           90
                   ....*....|
gi 148229403   440 SDKKQLSIQI 449
Cdd:pfam00028   82 SSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
142-234 6.17e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 62.70  E-value: 6.17e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148229403   142 EISESASLRTRIPLDRALDPDTGPNTLHSYTLS---PSEHFALDVIVGpdqtkhaELVVVKELDREIHSYFDLVLTAYDS 218
Cdd:pfam00028    4 SVPENAPVGTEVLTVTATDPDLGPNGRIFYSILgggPGGNFRIDPDTG-------DISTTKPLDRESIGEYELTVEATDS 76

                           90
                   ....*....|....*.
gi 148229403   219 GNPPKSGTSLVKVSVL 234
Cdd:pfam00028   77 GGPPLSSTATVTITVL 92
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 30-110 1.29e-11

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


Pssm-ID: 462413  Cd Length: 83  Bit Score: 61.39  E-value: 1.29e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148229403    30 TVRYQVAEEVPSGTVIGKLPQERGREeePGQ-AGAAFQVLQLPQGLPIQVDSEDGVLSTGRRLDREQLCRQQDPCLVSFD 108
Cdd:pfam08266    1 QIRYSVPEETERGSFVGNLAKDLGLE--VGElAARGARVVSKGNKQYFQLNPETGDLLLNEKLDREELCGSTEPCVLHFQ 78


                   ..
gi 148229403   109 VL 110
Cdd:pfam08266   79 VL 80
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 622-692 5.69e-10

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 56.97  E-value: 5.69e-10
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 148229403    622 ARDADSGANGELLYTIRSGNEAGVFVLSPNLGQLFINvtnaSSL---TGSEWELEIVVEDRGSPSLQTRALLQV 692
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTT----KPLdreEQPEYTLTVEATDGGGPPLSSTATVTI 71
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 32-130 9.01e-09

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 53.86  E-value: 9.01e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148229403   32 RYQVAEEVPSGTVIGKLpqeRGREEEPGQAGAA-FQVLQLPQGLPIQVDSEDGVLSTGRRLDREQLCRqqdpclVSFDVL 110
Cdd:cd11304     3 EVSVPENAPPGTVVLTV---SATDPDSGENGEVtYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSS------YTLTVT 73

                          90       100
                  ....*....|....*....|....*
gi 148229403  111 AT-----GERALIHVEIQVLDINDH 130
Cdd:cd11304    74 ATdgggpPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
616-692 5.74e-08

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 51.53  E-value: 5.74e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148229403   616 LLVTIIARDADSGANGELLYTIRSGNEAGVFVLSPNLGQLFInvtnASSL---TGSEWELEIVVEDRGSPSLQTRALLQV 692
Cdd:pfam00028   14 EVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDIST----TKPLdreSIGEYELTVEATDSGGPPLSSTATVTI 89
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 65-132 2.84e-06

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 46.19  E-value: 2.84e-06
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 148229403     65 FQVLQLPQGLPIQVDSEDGVLSTGRRLDREQLCRqqdpclVSFDVLAT--GERAL---IHVEIQVLDINDHQP 132
Cdd:smart00112   15 YSILSGNDDGLFSIDPETGEITTTKPLDREEQPE------YTLTVEATdgGGPPLsstATVTITVLDVNDNAP 81
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 250-347 3.62e-31

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 117.80  E-value: 3.62e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148229403  250 LEIQEDAAPGTLLINLTATDPDQGPNGEVEYFLSKHVPLEVlntFNIDAKTGQVTLLQHLDYEKNPAYEVDVQARDLGPN 329
Cdd:cd11304     4 VSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGL---FSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|....*...
gi 148229403  330 PIPAHCKILIKVLDVNDN 347
Cdd:cd11304    81 PLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 266-349 6.06e-24

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 96.65  E-value: 6.06e-24
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148229403    266 TATDPDQGPNGEVEYFLskhVPLEVLNTFNIDAKTGQVTLLQHLDYEKNPAYEVDVQARDLGPNPIPAHCKILIKVLDVN 345
Cdd:smart00112    1 SATDADSGENGKVTYSI---LSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                    ....
gi 148229403    346 DNAP 349
Cdd:smart00112   78 DNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 464-560 7.44e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 97.00  E-value: 7.44e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148229403  464 YQVSTRENNLPSLHLITIKAHDADLGVNGKISYRIQDSPVAHLVAIDSDTGEVTAQRSLDYEQMASFEFLVIAEDSGQPQ 543
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                          90
                  ....*....|....*..
gi 148229403  544 LSSSVSVWVSLLDANDN 560
Cdd:cd11304    82 LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 138-239 8.36e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 93.92  E-value: 8.36e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148229403  138 EQELEISESASLRTRIPLDRALDPDTGPNTLHSYTLS---PSEHFALDVIVGpdqtkhaELVVVKELDREIHSYFDLVLT 214
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsgnEDGLFSIDPSTG-------EITTAKPLDREEQSSYTLTVT 73

                          90       100
                  ....*....|....*....|....*
gi 148229403  215 AYDSGNPPKSGTSLVKVSVLDSNDN 239
Cdd:cd11304    74 ATDGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 362-455 2.37e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 92.76  E-value: 2.37e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148229403  362 VSEALPKDSFIALIMANDLDSGNNGLVHCWLSQ--ELGHFRLKRTNGNtymLLTNATLDREQWPQYTLTLLAQDQGPQPL 439
Cdd:cd11304     6 VPENAPPGTVVLTVSATDPDSGENGEVTYSIVSgnEDGLFSIDPSTGE---ITTAKPLDREEQSSYTLTVTATDGGGPPL 82

                          90
                  ....*....|....*.
gi 148229403  440 SDKKQLSIQISDANDN 455
Cdd:cd11304    83 SSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 482-562 1.02e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 84.71  E-value: 1.02e-19
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148229403    482 KAHDADLGVNGKISYRIQDSPVAHLVAIDSDTGEVTAQRSLDYEQMASFEFLVIAEDSGQPQLSSSVSVWVSLLDANDNA 561
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 148229403    562 P 562
Cdd:smart00112   81 P 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 377-457 3.25e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 83.17  E-value: 3.25e-19
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148229403    377 ANDLDSGNNGLVHCWLSQ--ELGHFRLKRTNGntyMLLTNATLDREQWPQYTLTLLAQDQGPQPLSDKKQLSIQISDAND 454
Cdd:smart00112    2 ATDADSGENGKVTYSILSgnDDGLFSIDPETG---EITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVND 78


                    ...
gi 148229403    455 NAP 457
Cdd:smart00112   79 NAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 157-241 1.59e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 81.24  E-value: 1.59e-18
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148229403    157 RALDPDTGPNTLHSYTLSPSE---HFALDVIVGpdqtkhaELVVVKELDREIHSYFDLVLTAYDSGNPPKSGTSLVKVSV 233
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNddgLFSIDPETG-------EITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITV 73


                    ....*...
gi 148229403    234 LDSNDNSP 241
Cdd:smart00112   74 LDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
251-342 1.70e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 81.58  E-value: 1.70e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148229403   251 EIQEDAAPGTLLINLTATDPDQGPNGEVEYFLSKHvplEVLNTFNIDAKTGQVTLLQHLDYEKNPAYEVDVQARDLGPNP 330
Cdd:pfam00028    4 SVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGG---GPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|..
gi 148229403   331 IPAHCKILIKVL 342
Cdd:pfam00028   81 LSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
464-542 3.82e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 80.42  E-value: 3.82e-18
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 148229403   464 YQVSTRENNLPSLHLITIKAHDADLGVNGKISYRIQDSPVAHLVAIDSDTGEVTAQRSLDYEQMASFEFLVIAEDSGQP 542
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGP 79
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 616-692 1.43e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 70.42  E-value: 1.43e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148229403  616 LLVTIIARDADSGANGELLYTIRSGNEAGVFVLSPNLGQLFINvtnaSSL---TGSEWELEIVVEDRGSPSLQTRALLQV 692
Cdd:cd11304    15 VVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTA----KPLdreEQSSYTLTVTATDGGGPPLSSTATVTI 90
Cadherin pfam00028
Cadherin domain;
362-449 3.31e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 63.47  E-value: 3.31e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148229403   362 VSEALPKDSFIALIMANDLDSGNNGLVHCWLSQ--ELGHFRLKRTNGntyMLLTNATLDREQWPQYTLTLLAQDQGPQPL 439
Cdd:pfam00028    5 VPENAPVGTEVLTVTATDPDLGPNGRIFYSILGggPGGNFRIDPDTG---DISTTKPLDRESIGEYELTVEATDSGGPPL 81

                           90
                   ....*....|
gi 148229403   440 SDKKQLSIQI 449
Cdd:pfam00028   82 SSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
142-234 6.17e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 62.70  E-value: 6.17e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148229403   142 EISESASLRTRIPLDRALDPDTGPNTLHSYTLS---PSEHFALDVIVGpdqtkhaELVVVKELDREIHSYFDLVLTAYDS 218
Cdd:pfam00028    4 SVPENAPVGTEVLTVTATDPDLGPNGRIFYSILgggPGGNFRIDPDTG-------DISTTKPLDRESIGEYELTVEATDS 76

                           90
                   ....*....|....*.
gi 148229403   219 GNPPKSGTSLVKVSVL 234
Cdd:pfam00028   77 GGPPLSSTATVTITVL 92
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 30-110 1.29e-11

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


Pssm-ID: 462413  Cd Length: 83  Bit Score: 61.39  E-value: 1.29e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148229403    30 TVRYQVAEEVPSGTVIGKLPQERGREeePGQ-AGAAFQVLQLPQGLPIQVDSEDGVLSTGRRLDREQLCRQQDPCLVSFD 108
Cdd:pfam08266    1 QIRYSVPEETERGSFVGNLAKDLGLE--VGElAARGARVVSKGNKQYFQLNPETGDLLLNEKLDREELCGSTEPCVLHFQ 78


                   ..
gi 148229403   109 VL 110
Cdd:pfam08266   79 VL 80
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 622-692 5.69e-10

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 56.97  E-value: 5.69e-10
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 148229403    622 ARDADSGANGELLYTIRSGNEAGVFVLSPNLGQLFINvtnaSSL---TGSEWELEIVVEDRGSPSLQTRALLQV 692
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTT----KPLdreEQPEYTLTVEATDGGGPPLSSTATVTI 71
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 32-130 9.01e-09

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 53.86  E-value: 9.01e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148229403   32 RYQVAEEVPSGTVIGKLpqeRGREEEPGQAGAA-FQVLQLPQGLPIQVDSEDGVLSTGRRLDREQLCRqqdpclVSFDVL 110
Cdd:cd11304     3 EVSVPENAPPGTVVLTV---SATDPDSGENGEVtYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSS------YTLTVT 73

                          90       100
                  ....*....|....*....|....*
gi 148229403  111 AT-----GERALIHVEIQVLDINDH 130
Cdd:cd11304    74 ATdgggpPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
616-692 5.74e-08

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 51.53  E-value: 5.74e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148229403   616 LLVTIIARDADSGANGELLYTIRSGNEAGVFVLSPNLGQLFInvtnASSL---TGSEWELEIVVEDRGSPSLQTRALLQV 692
Cdd:pfam00028   14 EVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDIST----TKPLdreSIGEYELTVEATDSGGPPLSSTATVTI 89
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 65-132 2.84e-06

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 46.19  E-value: 2.84e-06
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 148229403     65 FQVLQLPQGLPIQVDSEDGVLSTGRRLDREQLCRqqdpclVSFDVLAT--GERAL---IHVEIQVLDINDHQP 132
Cdd:smart00112   15 YSILSGNDDGLFSIDPETGEITTTKPLDREEQPE------YTLTVEATdgGGPPLsstATVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
34-95 7.10e-03

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 36.89  E-value: 7.10e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 148229403    34 QVAEEVPSGTVIGKLPQERgrEEEPGQAGAAFQVLQLPQGLPIQVDSEDGVLSTGRRLDREQ 95
Cdd:pfam00028    4 SVPENAPVGTEVLTVTATD--PDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRES 63
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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