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Conserved domains on  [gi|303304977|ref|NP_001091082|]
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Golgi pH regulator A isoform 2 [Homo sapiens]

Protein Classification

Golgi pH regulator family protein( domain architecture ID 10576101)

Golgi pH regulator (GPHR) family protein similar to human Golgi pH regulator B, a voltage dependent anion channel required for acidification and functions of the Golgi apparatus that may function in counter-ion conductance

Gene Ontology:  GO:0000139|GO:0006811|GO:0008308
PubMed:  18794847|19135895
TCDB:  1.A.38

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ABA_GPCR pfam12430
Abscisic acid G-protein coupled receptor; This domain family is found in eukaryotes, and is ...
 251-421 5.39e-40

Abscisic acid G-protein coupled receptor; This domain family is found in eukaryotes, and is typically between 177 and 216 amino acids in length. This family is part of the abscisic acid (ABA) G-protein coupled receptor. ABA is a stress hormone in plants.


:

Pssm-ID: 463577  Cd Length: 186  Bit Score: 141.21  E-value: 5.39e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 303304977  251 EYSKTFKGKYFNFLGYFFSIYCVWKIFMATINIVFDRVGK----------TDPVTRGI-EITVNYLGIQFDVKFWSQHIS 319
Cdd:pfam12430   1 QRSSTLLGKLLNVFGYAFSIYCVYRILNTLLNLLPRIYSHsfnlfassssSDPIARTLaKLLLRHFDPDLDLDAWSRQIS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 303304977  320 FILVGIIIVTSIRGLLITLTKFFYAISSS--KSSNVIVLLLAQIMGMYFVSSVLLIRMSMPLEYRTIITEVLGELQF--N 395
Cdd:pfam12430  81 LLLSGVLFLCSFSSVLTTFSSFLRLLPSLlqKSSALLALLVSQLMGIYVISTALLLRSNLPPEVSSALSELLGSLPLvpF 160

                         170       180
                  ....*....|....*....|....*.
gi 303304977  396 FYHRWFDVIFLVSALSSILFLYLAHK 421
Cdd:pfam12430 161 FIDRWFDGVFLLSCILTAVGIWVGRR 186
GPHR_N pfam12537
The Golgi pH Regulator (GPHR) Family N-terminal; GPHR_N is the N-terminal 5TM region of the ...
 115-182 2.83e-26

The Golgi pH Regulator (GPHR) Family N-terminal; GPHR_N is the N-terminal 5TM region of the Golgi pH regulator proteins in eukaryotes. It plays vital roles in the transport of newly synthesized proteins from the Golgi to the plasma membrane, in the glycosylation of proteins along the exocytic pathway and the structural organization of the Golgi apparatus.


:

Pssm-ID: 463623  Cd Length: 68  Bit Score: 100.68  E-value: 2.83e-26
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 303304977  115 ILSIEQLISRVGVIGVTLMALLSGFGAVNCPYTYMSYFLRNVTDTDILALERRLLQTMDMIISKKKRM 182
Cdd:pfam12537   1 FFLIENVLSRVGVIGVTLMAILSGFGAVSTPYYTFSLFLRPVTESDINNLERRLEHTRDLLAEKRKEL 68
 
Name Accession Description Interval E-value
ABA_GPCR pfam12430
Abscisic acid G-protein coupled receptor; This domain family is found in eukaryotes, and is ...
 251-421 5.39e-40

Abscisic acid G-protein coupled receptor; This domain family is found in eukaryotes, and is typically between 177 and 216 amino acids in length. This family is part of the abscisic acid (ABA) G-protein coupled receptor. ABA is a stress hormone in plants.


Pssm-ID: 463577  Cd Length: 186  Bit Score: 141.21  E-value: 5.39e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 303304977  251 EYSKTFKGKYFNFLGYFFSIYCVWKIFMATINIVFDRVGK----------TDPVTRGI-EITVNYLGIQFDVKFWSQHIS 319
Cdd:pfam12430   1 QRSSTLLGKLLNVFGYAFSIYCVYRILNTLLNLLPRIYSHsfnlfassssSDPIARTLaKLLLRHFDPDLDLDAWSRQIS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 303304977  320 FILVGIIIVTSIRGLLITLTKFFYAISSS--KSSNVIVLLLAQIMGMYFVSSVLLIRMSMPLEYRTIITEVLGELQF--N 395
Cdd:pfam12430  81 LLLSGVLFLCSFSSVLTTFSSFLRLLPSLlqKSSALLALLVSQLMGIYVISTALLLRSNLPPEVSSALSELLGSLPLvpF 160

                         170       180
                  ....*....|....*....|....*.
gi 303304977  396 FYHRWFDVIFLVSALSSILFLYLAHK 421
Cdd:pfam12430 161 FIDRWFDGVFLLSCILTAVGIWVGRR 186
GPHR_N pfam12537
The Golgi pH Regulator (GPHR) Family N-terminal; GPHR_N is the N-terminal 5TM region of the ...
 115-182 2.83e-26

The Golgi pH Regulator (GPHR) Family N-terminal; GPHR_N is the N-terminal 5TM region of the Golgi pH regulator proteins in eukaryotes. It plays vital roles in the transport of newly synthesized proteins from the Golgi to the plasma membrane, in the glycosylation of proteins along the exocytic pathway and the structural organization of the Golgi apparatus.


Pssm-ID: 463623  Cd Length: 68  Bit Score: 100.68  E-value: 2.83e-26
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 303304977  115 ILSIEQLISRVGVIGVTLMALLSGFGAVNCPYTYMSYFLRNVTDTDILALERRLLQTMDMIISKKKRM 182
Cdd:pfam12537   1 FFLIENVLSRVGVIGVTLMAILSGFGAVSTPYYTFSLFLRPVTESDINNLERRLEHTRDLLAEKRKEL 68
 
Name Accession Description Interval E-value
ABA_GPCR pfam12430
Abscisic acid G-protein coupled receptor; This domain family is found in eukaryotes, and is ...
 251-421 5.39e-40

Abscisic acid G-protein coupled receptor; This domain family is found in eukaryotes, and is typically between 177 and 216 amino acids in length. This family is part of the abscisic acid (ABA) G-protein coupled receptor. ABA is a stress hormone in plants.


Pssm-ID: 463577  Cd Length: 186  Bit Score: 141.21  E-value: 5.39e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 303304977  251 EYSKTFKGKYFNFLGYFFSIYCVWKIFMATINIVFDRVGK----------TDPVTRGI-EITVNYLGIQFDVKFWSQHIS 319
Cdd:pfam12430   1 QRSSTLLGKLLNVFGYAFSIYCVYRILNTLLNLLPRIYSHsfnlfassssSDPIARTLaKLLLRHFDPDLDLDAWSRQIS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 303304977  320 FILVGIIIVTSIRGLLITLTKFFYAISSS--KSSNVIVLLLAQIMGMYFVSSVLLIRMSMPLEYRTIITEVLGELQF--N 395
Cdd:pfam12430  81 LLLSGVLFLCSFSSVLTTFSSFLRLLPSLlqKSSALLALLVSQLMGIYVISTALLLRSNLPPEVSSALSELLGSLPLvpF 160

                         170       180
                  ....*....|....*....|....*.
gi 303304977  396 FYHRWFDVIFLVSALSSILFLYLAHK 421
Cdd:pfam12430 161 FIDRWFDGVFLLSCILTAVGIWVGRR 186
GPHR_N pfam12537
The Golgi pH Regulator (GPHR) Family N-terminal; GPHR_N is the N-terminal 5TM region of the ...
 115-182 2.83e-26

The Golgi pH Regulator (GPHR) Family N-terminal; GPHR_N is the N-terminal 5TM region of the Golgi pH regulator proteins in eukaryotes. It plays vital roles in the transport of newly synthesized proteins from the Golgi to the plasma membrane, in the glycosylation of proteins along the exocytic pathway and the structural organization of the Golgi apparatus.


Pssm-ID: 463623  Cd Length: 68  Bit Score: 100.68  E-value: 2.83e-26
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 303304977  115 ILSIEQLISRVGVIGVTLMALLSGFGAVNCPYTYMSYFLRNVTDTDILALERRLLQTMDMIISKKKRM 182
Cdd:pfam12537   1 FFLIENVLSRVGVIGVTLMAILSGFGAVSTPYYTFSLFLRPVTESDINNLERRLEHTRDLLAEKRKEL 68
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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