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Conserved domains on  [gi|145334755|ref|NP_001078723|]
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Hyaluronan / mRNA binding family [Arabidopsis thaliana]

Protein Classification

Stm1_N and HABP4_PAI-RBP1 domain-containing protein( domain architecture ID 10560294)

Stm1_N and HABP4_PAI-RBP1 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Stm1_N pfam09598
Stm1; This region is found at the N terminal of the Stm1 protein. Stm1 is a G4 quadraplex and ...
 1-61 1.89e-14

Stm1; This region is found at the N terminal of the Stm1 protein. Stm1 is a G4 quadraplex and purine motif triplex nucleic acid-binding protein. It has been implicated in many biological processes including apoptosis and telomere biosynthesis. Stm1 is known to interact with CDC13, and is known to associate with ribosomes and nuclear telomere cap complexes.


:

Pssm-ID: 430706  Cd Length: 64  Bit Score: 66.99  E-value: 1.89e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 145334755    1 MASLNPFDLLGDD-AEDPSQLAVAlsqkVEKAAAAVQPPKAAKFPTKPAPPSQAVRESRNAP 61
Cdd:pfam09598   1 MASKNLFDLLGNDdEEDPSQREPA----PPTKAVDKPTARTAKRPAKPEPPAQAVREARNDG 58
HABP4_PAI-RBP1 pfam04774
Hyaluronan / mRNA binding family; This family includes the HABP4 family of hyaluronan-binding ...
 147-247 1.59e-11

Hyaluronan / mRNA binding family; This family includes the HABP4 family of hyaluronan-binding proteins, and the PAI-1 mRNA-binding protein, PAI-RBP1. HABP4 has been observed to bind hyaluronan (a glucosaminoglycan), but it is not known whether this is its primary role in vivo. It has also been observed to bind RNA, but with a lower affinity than that for hyaluronan. PAI-1 mRNA-binding protein specifically binds the mRNA of type-1 plasminogen activator inhibitor (PAI-1), and is thought to be involved in regulation of mRNA stability. However, in both cases, the sequence motifs predicted to be important for ligand binding are not conserved throughout the family, so it is not known whether members of this family share a common function.


:

Pssm-ID: 461421  Cd Length: 108  Bit Score: 60.08  E-value: 1.59e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334755  147 PPRNYDRHSRTGHGTGMKRNGGGRGNWGTTEDDI-PPTSEEPTTEVEKSPVAEKQGGEDETPEAKKEltaEEKAQKEAEE 225
Cdd:pfam04774   1 GKREFDRHSGTGRGPEEKRDGAGRHNWGTVKDEIeAPEEEEAENEMEKNNDAEKEAGEEETDENEEA---AAAEEEEKEP 77

                          90       100
                  ....*....|....*....|..
gi 145334755  226 AEAREMTLEEYEKILEEKKKAP 247
Cdd:pfam04774  78 NEDKEMTLDEYKKVQEEKRALP 99
 
Name Accession Description Interval E-value
Stm1_N pfam09598
Stm1; This region is found at the N terminal of the Stm1 protein. Stm1 is a G4 quadraplex and ...
 1-61 1.89e-14

Stm1; This region is found at the N terminal of the Stm1 protein. Stm1 is a G4 quadraplex and purine motif triplex nucleic acid-binding protein. It has been implicated in many biological processes including apoptosis and telomere biosynthesis. Stm1 is known to interact with CDC13, and is known to associate with ribosomes and nuclear telomere cap complexes.


Pssm-ID: 430706  Cd Length: 64  Bit Score: 66.99  E-value: 1.89e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 145334755    1 MASLNPFDLLGDD-AEDPSQLAVAlsqkVEKAAAAVQPPKAAKFPTKPAPPSQAVRESRNAP 61
Cdd:pfam09598   1 MASKNLFDLLGNDdEEDPSQREPA----PPTKAVDKPTARTAKRPAKPEPPAQAVREARNDG 58
HABP4_PAI-RBP1 pfam04774
Hyaluronan / mRNA binding family; This family includes the HABP4 family of hyaluronan-binding ...
 147-247 1.59e-11

Hyaluronan / mRNA binding family; This family includes the HABP4 family of hyaluronan-binding proteins, and the PAI-1 mRNA-binding protein, PAI-RBP1. HABP4 has been observed to bind hyaluronan (a glucosaminoglycan), but it is not known whether this is its primary role in vivo. It has also been observed to bind RNA, but with a lower affinity than that for hyaluronan. PAI-1 mRNA-binding protein specifically binds the mRNA of type-1 plasminogen activator inhibitor (PAI-1), and is thought to be involved in regulation of mRNA stability. However, in both cases, the sequence motifs predicted to be important for ligand binding are not conserved throughout the family, so it is not known whether members of this family share a common function.


Pssm-ID: 461421  Cd Length: 108  Bit Score: 60.08  E-value: 1.59e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334755  147 PPRNYDRHSRTGHGTGMKRNGGGRGNWGTTEDDI-PPTSEEPTTEVEKSPVAEKQGGEDETPEAKKEltaEEKAQKEAEE 225
Cdd:pfam04774   1 GKREFDRHSGTGRGPEEKRDGAGRHNWGTVKDEIeAPEEEEAENEMEKNNDAEKEAGEEETDENEEA---AAAEEEEKEP 77

                          90       100
                  ....*....|....*....|..
gi 145334755  226 AEAREMTLEEYEKILEEKKKAP 247
Cdd:pfam04774  78 NEDKEMTLDEYKKVQEEKRALP 99
 
Name Accession Description Interval E-value
Stm1_N pfam09598
Stm1; This region is found at the N terminal of the Stm1 protein. Stm1 is a G4 quadraplex and ...
 1-61 1.89e-14

Stm1; This region is found at the N terminal of the Stm1 protein. Stm1 is a G4 quadraplex and purine motif triplex nucleic acid-binding protein. It has been implicated in many biological processes including apoptosis and telomere biosynthesis. Stm1 is known to interact with CDC13, and is known to associate with ribosomes and nuclear telomere cap complexes.


Pssm-ID: 430706  Cd Length: 64  Bit Score: 66.99  E-value: 1.89e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 145334755    1 MASLNPFDLLGDD-AEDPSQLAVAlsqkVEKAAAAVQPPKAAKFPTKPAPPSQAVRESRNAP 61
Cdd:pfam09598   1 MASKNLFDLLGNDdEEDPSQREPA----PPTKAVDKPTARTAKRPAKPEPPAQAVREARNDG 58
HABP4_PAI-RBP1 pfam04774
Hyaluronan / mRNA binding family; This family includes the HABP4 family of hyaluronan-binding ...
 147-247 1.59e-11

Hyaluronan / mRNA binding family; This family includes the HABP4 family of hyaluronan-binding proteins, and the PAI-1 mRNA-binding protein, PAI-RBP1. HABP4 has been observed to bind hyaluronan (a glucosaminoglycan), but it is not known whether this is its primary role in vivo. It has also been observed to bind RNA, but with a lower affinity than that for hyaluronan. PAI-1 mRNA-binding protein specifically binds the mRNA of type-1 plasminogen activator inhibitor (PAI-1), and is thought to be involved in regulation of mRNA stability. However, in both cases, the sequence motifs predicted to be important for ligand binding are not conserved throughout the family, so it is not known whether members of this family share a common function.


Pssm-ID: 461421  Cd Length: 108  Bit Score: 60.08  E-value: 1.59e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334755  147 PPRNYDRHSRTGHGTGMKRNGGGRGNWGTTEDDI-PPTSEEPTTEVEKSPVAEKQGGEDETPEAKKEltaEEKAQKEAEE 225
Cdd:pfam04774   1 GKREFDRHSGTGRGPEEKRDGAGRHNWGTVKDEIeAPEEEEAENEMEKNNDAEKEAGEEETDENEEA---AAAEEEEKEP 77

                          90       100
                  ....*....|....*....|..
gi 145334755  226 AEAREMTLEEYEKILEEKKKAP 247
Cdd:pfam04774  78 NEDKEMTLDEYKKVQEEKRALP 99
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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