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Conserved domains on  [gi|145332851|ref|NP_001078291|]
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LisH/CRA/RING-U-box domains-containing protein [Arabidopsis thaliana]

Protein Classification

CLTH domain-containing protein( domain architecture ID 12107814)

CLTH domain-containing protein similar to Saccharomyces cerevisiae glucose-induced degradation protein 8 (GID8) and GID9

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CTLH pfam10607
CTLH/CRA C-terminal to LisH motif domain; RanBPM is a scaffolding protein and is important in ...
 179-323 1.73e-50

CTLH/CRA C-terminal to LisH motif domain; RanBPM is a scaffolding protein and is important in regulating cellular function in both the immune system and the nervous system. This domain is at the C-terminus of the proteins and is the binding domain for the CRA motif (for CT11-RanBPM), which is comprised of approximately 100 amino acids at the C terminal of RanBPM. It was found to be important for the interaction of RanBPM with fragile X mental retardation protein (FMRP), but its functional significance has yet to be determined. This region contains CTLH and CRA domains annotated by SMART; however, these may be a single domain, and it is refereed to as a C-terminal to LisH motif.


:

Pssm-ID: 402305 [Multi-domain]  Cd Length: 143  Bit Score: 164.28  E-value: 1.73e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332851  179 IFREAKKVIDALKNREVASALTWCADNKTRLKKSKSKFEFQLRLQEFIELVRVDtaeSYKKAIQYARKHLASWGTTHMKE 258
Cdd:pfam10607   1 VFKERNRILEAILNGDITEAIEWCNENKPELLKINSNLEFELRLQQFIELIRSG---KILEALEYARENLAPFNEEHLKE 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 145332851  259 LQHVLATLAFKSTTECSKYKVLFELRQWDVLVDQFKQEFCKLYGMTMEPLLNIYLQAGLSALKTP 323
Cdd:pfam10607  78 LEKLMGLLAFPDPTDSSPYKSLLSPSRWEKLASEFNRAILKLLGLSSESPLEILLKAGLSALKTL 142
 
Name Accession Description Interval E-value
CTLH pfam10607
CTLH/CRA C-terminal to LisH motif domain; RanBPM is a scaffolding protein and is important in ...
 179-323 1.73e-50

CTLH/CRA C-terminal to LisH motif domain; RanBPM is a scaffolding protein and is important in regulating cellular function in both the immune system and the nervous system. This domain is at the C-terminus of the proteins and is the binding domain for the CRA motif (for CT11-RanBPM), which is comprised of approximately 100 amino acids at the C terminal of RanBPM. It was found to be important for the interaction of RanBPM with fragile X mental retardation protein (FMRP), but its functional significance has yet to be determined. This region contains CTLH and CRA domains annotated by SMART; however, these may be a single domain, and it is refereed to as a C-terminal to LisH motif.


Pssm-ID: 402305 [Multi-domain]  Cd Length: 143  Bit Score: 164.28  E-value: 1.73e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332851  179 IFREAKKVIDALKNREVASALTWCADNKTRLKKSKSKFEFQLRLQEFIELVRVDtaeSYKKAIQYARKHLASWGTTHMKE 258
Cdd:pfam10607   1 VFKERNRILEAILNGDITEAIEWCNENKPELLKINSNLEFELRLQQFIELIRSG---KILEALEYARENLAPFNEEHLKE 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 145332851  259 LQHVLATLAFKSTTECSKYKVLFELRQWDVLVDQFKQEFCKLYGMTMEPLLNIYLQAGLSALKTP 323
Cdd:pfam10607  78 LEKLMGLLAFPDPTDSSPYKSLLSPSRWEKLASEFNRAILKLLGLSSESPLEILLKAGLSALKTL 142
CRA smart00757
CT11-RanBPM; protein-protein interaction domain present in crown eukaryotes (plants, animals, ...
 235-323 4.21e-22

CT11-RanBPM; protein-protein interaction domain present in crown eukaryotes (plants, animals, fungi)


Pssm-ID: 214806  Cd Length: 99  Bit Score: 88.89  E-value: 4.21e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332851   235 ESYKKAIQYARKHLASWGTTH---MKELQHVLATLAFKSTTECSKYKVLFELRQWDVLVDQFKQEFCKLY-GMTMEPLLN 310
Cdd:smart00757   1 GKIEEALAYARELLAPFAKEHekfLKELEKTMALLAYPDPTEPSPYKELLSPSQREKLAEELNSAILELLhGKSSESPLE 80

                           90
                   ....*....|...
gi 145332851   311 IYLQAGLSALKTP 323
Cdd:smart00757  81 ILLSAGLAALKTL 93
COG5109 COG5109
Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only];
168-320 3.38e-04

Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only];


Pssm-ID: 227440 [Multi-domain]  Cd Length: 396  Bit Score: 41.92  E-value: 3.38e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332851 168 SSNIMDLVDI-DIFREAKKVIDALKNREVASALTWcADNKTRLKKSKSKFEFQLRLQEFIELVRVDTAesYKKAIQYARK 246
Cdd:COG5109  126 KDGKDEIIKIrDGFVKLKKVISGISEKSTFLLIEF-LQIEGYLSKGDTESELELYLVSHESLLLIHKR--YDEALRLCFT 202

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332851 247 HLASWGTTHMKELQHVLATLAFKSTTEC-SKYKVLFE---------------------LRQWDVLVDQFKQEFCKLYGMT 304
Cdd:COG5109  203 KLASFVPKHIQDVKPLLRFLVNAPTDCFrHREKELMQniqealkksligqpiedidkvNKSRKKLIELFKSEYCAANGMP 282

                        170
                 ....*....|....*.
gi 145332851 305 MEPLLNIYLQAGLSAL 320
Cdd:COG5109  283 NRSPLRELVETGTIAF 298
 
Name Accession Description Interval E-value
CTLH pfam10607
CTLH/CRA C-terminal to LisH motif domain; RanBPM is a scaffolding protein and is important in ...
 179-323 1.73e-50

CTLH/CRA C-terminal to LisH motif domain; RanBPM is a scaffolding protein and is important in regulating cellular function in both the immune system and the nervous system. This domain is at the C-terminus of the proteins and is the binding domain for the CRA motif (for CT11-RanBPM), which is comprised of approximately 100 amino acids at the C terminal of RanBPM. It was found to be important for the interaction of RanBPM with fragile X mental retardation protein (FMRP), but its functional significance has yet to be determined. This region contains CTLH and CRA domains annotated by SMART; however, these may be a single domain, and it is refereed to as a C-terminal to LisH motif.


Pssm-ID: 402305 [Multi-domain]  Cd Length: 143  Bit Score: 164.28  E-value: 1.73e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332851  179 IFREAKKVIDALKNREVASALTWCADNKTRLKKSKSKFEFQLRLQEFIELVRVDtaeSYKKAIQYARKHLASWGTTHMKE 258
Cdd:pfam10607   1 VFKERNRILEAILNGDITEAIEWCNENKPELLKINSNLEFELRLQQFIELIRSG---KILEALEYARENLAPFNEEHLKE 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 145332851  259 LQHVLATLAFKSTTECSKYKVLFELRQWDVLVDQFKQEFCKLYGMTMEPLLNIYLQAGLSALKTP 323
Cdd:pfam10607  78 LEKLMGLLAFPDPTDSSPYKSLLSPSRWEKLASEFNRAILKLLGLSSESPLEILLKAGLSALKTL 142
CRA smart00757
CT11-RanBPM; protein-protein interaction domain present in crown eukaryotes (plants, animals, ...
 235-323 4.21e-22

CT11-RanBPM; protein-protein interaction domain present in crown eukaryotes (plants, animals, fungi)


Pssm-ID: 214806  Cd Length: 99  Bit Score: 88.89  E-value: 4.21e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332851   235 ESYKKAIQYARKHLASWGTTH---MKELQHVLATLAFKSTTECSKYKVLFELRQWDVLVDQFKQEFCKLY-GMTMEPLLN 310
Cdd:smart00757   1 GKIEEALAYARELLAPFAKEHekfLKELEKTMALLAYPDPTEPSPYKELLSPSQREKLAEELNSAILELLhGKSSESPLE 80

                           90
                   ....*....|...
gi 145332851   311 IYLQAGLSALKTP 323
Cdd:smart00757  81 ILLSAGLAALKTL 93
CTLH smart00668
C-terminal to LisH motif; Alpha-helical motif of unknown function.
 179-236 1.56e-11

C-terminal to LisH motif; Alpha-helical motif of unknown function.


Pssm-ID: 128914  Cd Length: 58  Bit Score: 58.74  E-value: 1.56e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 145332851   179 IFREAKKVIDALKNREVASALTWCADNKTRLKKSKSKFEFQLRLQEFIELVRVDTAES 236
Cdd:smart00668   1 EFDERKRIRELILKGDWDEALEWLSSLKPPLLERNSKLEFELRKQKFLELVRQGKLEE 58
COG5109 COG5109
Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only];
168-320 3.38e-04

Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only];


Pssm-ID: 227440 [Multi-domain]  Cd Length: 396  Bit Score: 41.92  E-value: 3.38e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332851 168 SSNIMDLVDI-DIFREAKKVIDALKNREVASALTWcADNKTRLKKSKSKFEFQLRLQEFIELVRVDTAesYKKAIQYARK 246
Cdd:COG5109  126 KDGKDEIIKIrDGFVKLKKVISGISEKSTFLLIEF-LQIEGYLSKGDTESELELYLVSHESLLLIHKR--YDEALRLCFT 202

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332851 247 HLASWGTTHMKELQHVLATLAFKSTTEC-SKYKVLFE---------------------LRQWDVLVDQFKQEFCKLYGMT 304
Cdd:COG5109  203 KLASFVPKHIQDVKPLLRFLVNAPTDCFrHREKELMQniqealkksligqpiedidkvNKSRKKLIELFKSEYCAANGMP 282

                        170
                 ....*....|....*.
gi 145332851 305 MEPLLNIYLQAGLSAL 320
Cdd:COG5109  283 NRSPLRELVETGTIAF 298
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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