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Conserved domains on  [gi|145332679|ref|NP_001078205|]
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ATP-dependent caseinolytic (Clp) protease/crotonase family protein [Arabidopsis thaliana]

Protein Classification

enoyl-CoA hydratase/isomerase family protein( domain architecture ID 11240944)

enoyl-CoA hydratase/isomerase family protein plays a role in fatty acid metabolism, which involves stabilization of an enolate anion intermediate derived from an acyl-CoA substrate; similar to Homo sapiens 3-hydroxyisobutyryl-CoA hydrolase and Cereibacter sphaeroides Enoyl-CoA hydratase

CATH:  3.90.226.10
EC:  3.1.2.-
Gene Ontology:  GO:0016790
PubMed:  18470480|11263873
SCOP:  4004188

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ECH_2 pfam16113
Enoyl-CoA hydratase/isomerase; This family contains a diverse set of enzymes including: ...
 56-402 1.28e-145

Enoyl-CoA hydratase/isomerase; This family contains a diverse set of enzymes including: enoyl-CoA hydratase, napthoate synthase, carnitate racemase, 3-hydroxybutyryl-CoA dehydratase and dodecanoyl-CoA delta-isomerase. This family differs from pfam00378 in the structure of it's C-terminus.


:

Pssm-ID: 465024 [Multi-domain]  Cd Length: 331  Bit Score: 416.87  E-value: 1.28e-145
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679   56 VALITLDRPKALNAMNLEMDLKYKSLLDEWEYDPGVKCVVVEGSTSRAFCAGGDVKQIT---SKNQLSDMIEVFTAEYSL 132
Cdd:pfam16113   1 VGVITLNRPKALNALNLEMVRALLAALKAWEDDPAVKLVVLKGAGERAFCAGGDVRALYeaaKAGGGEAGRDFFREEYRL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679  133 ICKIAGYRKPYISLMDGITMGFGLGLSGHGRYRVITERTVLAMPENGIGLFPDVGFSYIAAHSPGEgsVGAYLGMTGRRI 212
Cdd:pfam16113  81 NYLIATYPKPYVALMDGIVMGGGVGLSVHGSFRVVTERTRFAMPETAIGLFPDVGGSYFLSRLPGE--LGLYLALTGARL 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679  213 StPSDALFVGLGTHYVPSGKLGSLREAILSADLSKDPQqhIQATLSNYS-SDPETESHLQMLLPQIESAFSvSKSVKETI 291
Cdd:pfam16113 159 N-GADALAAGLATHYVPSARLPALEEALAALDWSDPAD--VDAVLAEFAeESDPPPSPLAAHREAIDRCFS-ADTVEEII 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679  292 EELKKfqqssEASVAEWANEAVQGIEKGAPFSLYLTHKYFSKvacakgktnNAMATLNGVMITEYRIALRSALRSDFTEG 371
Cdd:pfam16113 235 AALEA-----EADGDEWAAETLKTLRKRSPTSLKVTLRQLRR---------GRKLSLAECLRMEYRLALRCLRRPDFVEG 300

                         330       340       350
                  ....*....|....*....|....*....|.
gi 145332679  372 VRAVLTDKDQNPKWKPASLDEVDETEVDALF 402
Cdd:pfam16113 301 VRALLIDKDRNPKWSPATLEEVTDEMVDAYF 331
 
Name Accession Description Interval E-value
ECH_2 pfam16113
Enoyl-CoA hydratase/isomerase; This family contains a diverse set of enzymes including: ...
 56-402 1.28e-145

Enoyl-CoA hydratase/isomerase; This family contains a diverse set of enzymes including: enoyl-CoA hydratase, napthoate synthase, carnitate racemase, 3-hydroxybutyryl-CoA dehydratase and dodecanoyl-CoA delta-isomerase. This family differs from pfam00378 in the structure of it's C-terminus.


Pssm-ID: 465024 [Multi-domain]  Cd Length: 331  Bit Score: 416.87  E-value: 1.28e-145
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679   56 VALITLDRPKALNAMNLEMDLKYKSLLDEWEYDPGVKCVVVEGSTSRAFCAGGDVKQIT---SKNQLSDMIEVFTAEYSL 132
Cdd:pfam16113   1 VGVITLNRPKALNALNLEMVRALLAALKAWEDDPAVKLVVLKGAGERAFCAGGDVRALYeaaKAGGGEAGRDFFREEYRL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679  133 ICKIAGYRKPYISLMDGITMGFGLGLSGHGRYRVITERTVLAMPENGIGLFPDVGFSYIAAHSPGEgsVGAYLGMTGRRI 212
Cdd:pfam16113  81 NYLIATYPKPYVALMDGIVMGGGVGLSVHGSFRVVTERTRFAMPETAIGLFPDVGGSYFLSRLPGE--LGLYLALTGARL 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679  213 StPSDALFVGLGTHYVPSGKLGSLREAILSADLSKDPQqhIQATLSNYS-SDPETESHLQMLLPQIESAFSvSKSVKETI 291
Cdd:pfam16113 159 N-GADALAAGLATHYVPSARLPALEEALAALDWSDPAD--VDAVLAEFAeESDPPPSPLAAHREAIDRCFS-ADTVEEII 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679  292 EELKKfqqssEASVAEWANEAVQGIEKGAPFSLYLTHKYFSKvacakgktnNAMATLNGVMITEYRIALRSALRSDFTEG 371
Cdd:pfam16113 235 AALEA-----EADGDEWAAETLKTLRKRSPTSLKVTLRQLRR---------GRKLSLAECLRMEYRLALRCLRRPDFVEG 300

                         330       340       350
                  ....*....|....*....|....*....|.
gi 145332679  372 VRAVLTDKDQNPKWKPASLDEVDETEVDALF 402
Cdd:pfam16113 301 VRALLIDKDRNPKWSPATLEEVTDEMVDAYF 331
PRK05617 PRK05617
3-hydroxyisobutyryl-CoA hydrolase; Provisional
 54-404 5.56e-123

3-hydroxyisobutyryl-CoA hydrolase; Provisional


Pssm-ID: 235533 [Multi-domain]  Cd Length: 342  Bit Score: 359.90  E-value: 5.56e-123
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679  54 NGVALITLDRPKALNAMNLEMDLKYKSLLDEWEYDPGVKCVVVEGSTSRAFCAGGDVKQI----TSKNQLSDmIEVFTAE 129
Cdd:PRK05617  11 GGVGVITLNRPKALNALSLEMIRAIDAALDAWEDDDAVAAVVIEGAGERGFCAGGDIRALyeaaRAGDPLAA-DRFFREE 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679 130 YSLICKIAGYRKPYISLMDGITMGFGLGLSGHGRYRVITERTVLAMPENGIGLFPDVGFSYIAAHSPGEgsVGAYLGMTG 209
Cdd:PRK05617  90 YRLNALIARYPKPYIALMDGIVMGGGVGISAHGSHRIVTERTKMAMPETGIGFFPDVGGTYFLSRAPGA--LGTYLALTG 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679 210 RRIStPSDALFVGLGTHYVPSGKLGSLREAILSADLSKDpQQHIQATLSNYSSDPeTESHLQMLLPQIESAFSvSKSVKE 289
Cdd:PRK05617 168 ARIS-AADALYAGLADHFVPSADLPALLDALISLRWDSG-ADVVDAALAAFATPA-PASELAAQRAWIDECFA-GDTVED 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679 290 TIEELkkfqqssEASVAEWANEAVQGIEKGAPFSLYLTHKYFSKvacakgktnNAMATLNGVMITEYRIALRSALRSDFT 369
Cdd:PRK05617 244 IIAAL-------EADGGEFAAKTADTLRSRSPTSLKVTLEQLRR---------ARGLTLEECLRRELRLALAMLRSPDFV 307

                        330       340       350
                 ....*....|....*....|....*....|....*
gi 145332679 370 EGVRAVLTDKDQNPKWKPASLDEVDETEVDALFMP 404
Cdd:PRK05617 308 EGVRAVLIDKDRNPKWSPATLEDVTPEDVEAFFAP 342
crotonase-like cd06558
Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse ...
 54-233 6.10e-46

Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. Many of these play important roles in fatty acid metabolism. In addition to a conserved structural core and the formation of trimers (or dimers of trimers), a common feature in this superfamily is the stabilization of an enolate anion intermediate derived from an acyl-CoA substrate. This is accomplished by two conserved backbone NH groups in active sites that form an oxyanion hole.


Pssm-ID: 119339 [Multi-domain]  Cd Length: 195  Bit Score: 156.95  E-value: 6.10e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679  54 NGVALITLDRPKALNAMNLEMDLKYKSLLDEWEYDPGVKCVVVEGStSRAFCAGGDVKQITSKNQLSDMI-EVFTAEYSL 132
Cdd:cd06558    7 GGVATITLNRPEKRNALSLEMLDELAAALDEAEADPDVRVVVLTGA-GKAFCAGADLKELAALSDAGEEArAFIRELQEL 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679 133 ICKIAGYRKPYISLMDGITMGFGLGLSGHGRYRVITERTVLAMPENGIGLFPDVGFSYIAAHSPGeGSVGAYLGMTGRRI 212
Cdd:cd06558   86 LRALLRLPKPVIAAVNGAALGGGLELALACDIRIAAEDAKFGLPEVKLGLVPGGGGTQRLPRLVG-PARARELLLTGRRI 164

                        170       180
                 ....*....|....*....|.
gi 145332679 213 StPSDALFVGLGTHYVPSGKL 233
Cdd:cd06558  165 S-AEEALELGLVDEVVPDEEL 184
CaiD COG1024
Enoyl-CoA hydratase/carnithine racemase [Lipid transport and metabolism]; Enoyl-CoA hydratase ...
 54-256 1.77e-41

Enoyl-CoA hydratase/carnithine racemase [Lipid transport and metabolism]; Enoyl-CoA hydratase/carnithine racemase is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440647 [Multi-domain]  Cd Length: 249  Bit Score: 146.85  E-value: 1.77e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679  54 NGVALITLDRPKALNAMNLEMDLKYKSLLDEWEYDPGVKCVVVEGStSRAFCAGGDVKQITSKNQLSDMIEVFTAEYSLI 133
Cdd:COG1024    7 GGVATITLNRPEKLNALSLEMLAELAAALDEAEADPDVRVVVLTGA-GKAFCAGADLKELAAAADPEEARAFARGLQRLF 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679 134 CKIAGYRKPYISLMDGITMGFGLGLSGHGRYRVITERTVLAMPENGIGLFPDVGFSYIAAHSPGEGsVGAYLGMTGRRIS 213
Cdd:COG1024   86 RALRRLPKPVIAAVNGAALGGGLELALACDLRIAAEDARFGLPEVRLGLIPGGGGTQRLPRLVGLA-RAKELLLTGRRID 164

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 145332679 214 tPSDALFVGLGTHYVPSGKLgsLREAI-LSADLSKDPQQHIQAT 256
Cdd:COG1024  165 -AEEALELGLVNRVVPDDEL--LAAALaLAARLAAGPPLALAAT 205
fa_ox_alpha_mit TIGR02441
fatty acid oxidation complex, alpha subunit, mitochondrial; Members represent alpha subunit of ...
 54-212 1.25e-11

fatty acid oxidation complex, alpha subunit, mitochondrial; Members represent alpha subunit of mitochondrial multifunctional fatty acid degradation enzyme complex. Subunit activities include: enoyl-CoA hydratase (EC 4.2.1.17) _ 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35). Some characterization in human (SP:P40939), pig (SP:Q29554), and rat (SP:Q64428). The beta subunit has activity: acetyl-CoA C-acyltransferase (EC 2.3.1.16).


Pssm-ID: 131494 [Multi-domain]  Cd Length: 737  Bit Score: 66.40  E-value: 1.25e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679   54 NGVALITLDRPKA-LNAMNLEMDLKYKSLLDEWEYDPGVKCVVVEGSTSRAFCAGGDVKQITSKNQLSDMIEVFTAEYSL 132
Cdd:TIGR02441  21 GDVAVVKIDSPNSkVNTLSKELFAEFKEVMNELWTNEAIKSAVLISGKPGSFVAGADIQMIAACKTAQEVTQLSQEGQEM 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679  133 ICKIAGYRKPYISLMDGITMGFGLGLSGHGRYRVITE--RTVLAMPENGIGLFPDVGFSyiaAHSPGEGSVGAYLGM--T 208
Cdd:TIGR02441 101 FERIEKSQKPIVAAISGSCLGGGLELALACHYRIATKdrKTLLGLPEVMLGLLPGAGGT---QRLPKLTGVPAALDMmlT 177


                  ....
gi 145332679  209 GRRI 212
Cdd:TIGR02441 178 GKKI 181
 
Name Accession Description Interval E-value
ECH_2 pfam16113
Enoyl-CoA hydratase/isomerase; This family contains a diverse set of enzymes including: ...
 56-402 1.28e-145

Enoyl-CoA hydratase/isomerase; This family contains a diverse set of enzymes including: enoyl-CoA hydratase, napthoate synthase, carnitate racemase, 3-hydroxybutyryl-CoA dehydratase and dodecanoyl-CoA delta-isomerase. This family differs from pfam00378 in the structure of it's C-terminus.


Pssm-ID: 465024 [Multi-domain]  Cd Length: 331  Bit Score: 416.87  E-value: 1.28e-145
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679   56 VALITLDRPKALNAMNLEMDLKYKSLLDEWEYDPGVKCVVVEGSTSRAFCAGGDVKQIT---SKNQLSDMIEVFTAEYSL 132
Cdd:pfam16113   1 VGVITLNRPKALNALNLEMVRALLAALKAWEDDPAVKLVVLKGAGERAFCAGGDVRALYeaaKAGGGEAGRDFFREEYRL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679  133 ICKIAGYRKPYISLMDGITMGFGLGLSGHGRYRVITERTVLAMPENGIGLFPDVGFSYIAAHSPGEgsVGAYLGMTGRRI 212
Cdd:pfam16113  81 NYLIATYPKPYVALMDGIVMGGGVGLSVHGSFRVVTERTRFAMPETAIGLFPDVGGSYFLSRLPGE--LGLYLALTGARL 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679  213 StPSDALFVGLGTHYVPSGKLGSLREAILSADLSKDPQqhIQATLSNYS-SDPETESHLQMLLPQIESAFSvSKSVKETI 291
Cdd:pfam16113 159 N-GADALAAGLATHYVPSARLPALEEALAALDWSDPAD--VDAVLAEFAeESDPPPSPLAAHREAIDRCFS-ADTVEEII 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679  292 EELKKfqqssEASVAEWANEAVQGIEKGAPFSLYLTHKYFSKvacakgktnNAMATLNGVMITEYRIALRSALRSDFTEG 371
Cdd:pfam16113 235 AALEA-----EADGDEWAAETLKTLRKRSPTSLKVTLRQLRR---------GRKLSLAECLRMEYRLALRCLRRPDFVEG 300

                         330       340       350
                  ....*....|....*....|....*....|.
gi 145332679  372 VRAVLTDKDQNPKWKPASLDEVDETEVDALF 402
Cdd:pfam16113 301 VRALLIDKDRNPKWSPATLEEVTDEMVDAYF 331
PRK05617 PRK05617
3-hydroxyisobutyryl-CoA hydrolase; Provisional
 54-404 5.56e-123

3-hydroxyisobutyryl-CoA hydrolase; Provisional


Pssm-ID: 235533 [Multi-domain]  Cd Length: 342  Bit Score: 359.90  E-value: 5.56e-123
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679  54 NGVALITLDRPKALNAMNLEMDLKYKSLLDEWEYDPGVKCVVVEGSTSRAFCAGGDVKQI----TSKNQLSDmIEVFTAE 129
Cdd:PRK05617  11 GGVGVITLNRPKALNALSLEMIRAIDAALDAWEDDDAVAAVVIEGAGERGFCAGGDIRALyeaaRAGDPLAA-DRFFREE 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679 130 YSLICKIAGYRKPYISLMDGITMGFGLGLSGHGRYRVITERTVLAMPENGIGLFPDVGFSYIAAHSPGEgsVGAYLGMTG 209
Cdd:PRK05617  90 YRLNALIARYPKPYIALMDGIVMGGGVGISAHGSHRIVTERTKMAMPETGIGFFPDVGGTYFLSRAPGA--LGTYLALTG 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679 210 RRIStPSDALFVGLGTHYVPSGKLGSLREAILSADLSKDpQQHIQATLSNYSSDPeTESHLQMLLPQIESAFSvSKSVKE 289
Cdd:PRK05617 168 ARIS-AADALYAGLADHFVPSADLPALLDALISLRWDSG-ADVVDAALAAFATPA-PASELAAQRAWIDECFA-GDTVED 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679 290 TIEELkkfqqssEASVAEWANEAVQGIEKGAPFSLYLTHKYFSKvacakgktnNAMATLNGVMITEYRIALRSALRSDFT 369
Cdd:PRK05617 244 IIAAL-------EADGGEFAAKTADTLRSRSPTSLKVTLEQLRR---------ARGLTLEECLRRELRLALAMLRSPDFV 307

                        330       340       350
                 ....*....|....*....|....*....|....*
gi 145332679 370 EGVRAVLTDKDQNPKWKPASLDEVDETEVDALFMP 404
Cdd:PRK05617 308 EGVRAVLIDKDRNPKWSPATLEDVTPEDVEAFFAP 342
PLN02874 PLN02874
3-hydroxyisobutyryl-CoA hydrolase-like protein
 55-410 2.79e-71

3-hydroxyisobutyryl-CoA hydrolase-like protein


Pssm-ID: 178462 [Multi-domain]  Cd Length: 379  Bit Score: 228.92  E-value: 2.79e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679  55 GVALITLDRPKALNAMNLEMDLKYKSLLDEWEYDPGVKCVVVEGsTSRAFCAGGDVKQITSKNQLSD-MIEVFTAEYSLI 133
Cdd:PLN02874  20 RVRVITLNRPRQLNVISLSVVSLLAEFLEQWEKDDSVELIIIKG-AGRAFSAGGDLKMFYDGRESDDsCLEVVYRMYWLC 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679 134 CKIAGYRKPYISLMDGITMGFGLGLSGHGRYRVITERTVLAMPENGIGLFPDVGFSYIAAHSPGEgsVGAYLGMTGRRIS 213
Cdd:PLN02874  99 YHIHTYKKTQVALVHGLVMGGGAGLMVPMKFRVVTEKTVFATPEASVGFHTDCGFSYILSRLPGH--LGEYLALTGARLN 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679 214 TpSDALFVGLGTHYVPSGKLGSLREAILSadLSKDPQQHIQATLSNYSSDPE-TESHLQMLLPQIESAFSvsksvKETIE 292
Cdd:PLN02874 177 G-KEMVACGLATHFVPSEKLPELEKRLLN--LNSGDESAVQEAIEEFSKDVQaDEDSILNKQSWINECFS-----KDTVE 248

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679 293 EL-KKFQQSSEASVAEWANEAVQGIEKGAPFSLYLTHKyfskvACAKGKTNnamaTLNGVMITEYRI---ALRSALRSDF 368
Cdd:PLN02874 249 EIiKAFESEASKTGNEWIKETLKGLRRSSPTGLKITLR-----SIREGRKQ----SLAECLKKEFRLtmnILRSTVSDDV 319

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|..
gi 145332679 369 TEGVRAVLTDKDQNPKWKPASLDEVDETEVDALFMPLSPEFE 410
Cdd:PLN02874 320 YEGIRALVIDKDNAPKWNPSTLDEVTDEKVDLVFQPFKAREE 361
PLN02851 PLN02851
3-hydroxyisobutyryl-CoA hydrolase-like protein
 18-410 1.92e-61

3-hydroxyisobutyryl-CoA hydrolase-like protein


Pssm-ID: 178443 [Multi-domain]  Cd Length: 407  Bit Score: 204.06  E-value: 1.92e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679  18 SPSFLIPFSKL-SVSHRRKFSVMA--SGSDEFvKGNVYPNGVA---LITLDRPKALNAMNLEMDLKYKSLLDEWEYDPGV 91
Cdd:PLN02851   9 RVAVPLQWVRFgSVSYGRSFSALPnyAANDDL-QDQVLVEGRAksrAAILNRPSSLNALTIPMVARLKRLYESWEENPDI 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679  92 KCVVVEGStSRAFCAGGDV---KQITSKNQLSDMIEVFTAEYSLICKIAGYRKPYISLMDGITMGFGLGLSGHGRYRVIT 168
Cdd:PLN02851  88 GFVLMKGS-GRAFCSGADVvslYHLINEGNVEECKLFFENLYKFVYLQGTYLKPNVAIMDGITMGCGAGISIPGMFRVVT 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679 169 ERTVLAMPENGIGLFPDVGFSYIAAHSPgeGSVGAYLGMTGRRISTpSDALFVGLGTHYVPSGKLGSLREAIlsADLSKD 248
Cdd:PLN02851 167 DKTVFAHPEVQMGFHPDAGASYYLSRLP--GYLGEYLALTGQKLNG-VEMIACGLATHYCLNARLPLIEERL--GKLLTD 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679 249 PQQHIQATLSNYSS--DPETESHLQMlLPQIESAFSVSkSVKETIEELkkfQQSSEASVAEWANEAVQGIEKGAPFSLYL 326
Cdd:PLN02851 242 DPAVIEDSLAQYGDlvYPDKSSVLHK-IETIDKCFGHD-TVEEIIEAL---ENEAASSYDEWCKKALKKIKEASPLSLKV 316

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679 327 THKyfskvACAKGKtnnaMATLNGVMITEYRIAL---RSALRSDFTEGVRAVLTDKDQNPKWKPASLDEVDETEVDALFM 403
Cdd:PLN02851 317 TLQ-----SIREGR----FQTLDQCLAREYRISLcgvSKWVSGDFCEGVRARLVDKDFAPKWDPPSLGEVSKDMVDCYFT 387

                        410
                 ....*....|
gi 145332679 404 PLS---PEFE 410
Cdd:PLN02851 388 PLDeseSELE 397
PLN02988 PLN02988
3-hydroxyisobutyryl-CoA hydrolase
 39-410 4.93e-61

3-hydroxyisobutyryl-CoA hydrolase


Pssm-ID: 178568 [Multi-domain]  Cd Length: 381  Bit Score: 202.25  E-value: 4.93e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679  39 MASGSDEFVKGNvypNGVALITLDRPKALNAMNLEMDLKYKSLLDEWEYDPGVKCVVVEGStSRAFCAGGDVKQITSKNQ 118
Cdd:PLN02988   5 MASQSQVLVEEK---SSVRILTLNRPKQLNALSFHMISRLLQLFLAFEEDPSVKLVILKGH-GRAFCAGGDVAAVVRDIE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679 119 LSDM---IEVFTAEYSLICKIAGYRKPYISLMDGITMGFGLGLSGHGRYRVITERTVLAMPENGIGLFPDVGFSYIAAHS 195
Cdd:PLN02988  81 QGNWrlgANFFSDEYMLNYVMATYSKAQVSILNGIVMGGGAGVSVHGRFRIATENTVFAMPETALGLFPDVGASYFLSRL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679 196 PgeGSVGAYLGMTGRRISTpSDALFVGLGTHYVPSGKLGSLrEAILSADLSKDPqQHIQATLSNYSSDPETESHLQM-LL 274
Cdd:PLN02988 161 P--GFFGEYVGLTGARLDG-AEMLACGLATHFVPSTRLTAL-EADLCRIGSNDP-TFASTILDAYTQHPRLKPQSAYhRL 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679 275 PQIESAFSvSKSVKETIEELKKfQQSSEASvaEWANEAVQGIEKGAPFSLYLTHKYFSKvacakgktnnamATLNGV--- 351
Cdd:PLN02988 236 DVIDRCFS-RRTVEEIISALER-EATQEAD--GWISATIQALKKASPASLKISLRSIRE------------GRLQGVgqc 299

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 145332679 352 MITEYRI---ALRSALRSDFTEGVRAVLTDKDQNPKWKPASLDEVDETEVDALFMPLSPEFE 410
Cdd:PLN02988 300 LIREYRMvchVMKGEISKDFVEGCRAILVDKDKNPKWEPRRLEDMKDSMVEQYFERVEEEEE 361
PLN02157 PLN02157
3-hydroxyisobutyryl-CoA hydrolase-like protein
 61-414 1.76e-56

3-hydroxyisobutyryl-CoA hydrolase-like protein


Pssm-ID: 177817 [Multi-domain]  Cd Length: 401  Bit Score: 191.05  E-value: 1.76e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679  61 LDRPKALNAMNLEMDLKYKSLLDEWEYDPGVKCVVVEGStSRAFCAGGDV---KQITSKNQLSDMIEVFTAEYSLICKIA 137
Cdd:PLN02157  52 LNRPPALNALTTHMGYRLQKLYKNWEEDPNIGFVMMKGS-GRAFCAGGDIvslYHLRKRGSPDAIREFFSSLYSFIYLLG 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679 138 GYRKPYISLMDGITMGFGLGLSGHGRYRVITERTVLAMPENGIGLFPDVGFSYIAAHSPGEgsVGAYLGMTGRRISTpSD 217
Cdd:PLN02157 131 TYLKPHVAILNGVTMGGGTGVSIPGTFRVATDRTIFATPETIIGFHPDAGASFNLSHLPGR--LGEYLGLTGLKLSG-AE 207

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679 218 ALFVGLGTHYVPSGKLGSLREAiLSADLSKDPQQhIQATLSNYS--SDPETESHLQMlLPQIESAFSvSKSVKETIEELK 295
Cdd:PLN02157 208 MLACGLATHYIRSEEIPVMEEQ-LKKLLTDDPSV-VESCLEKCAevAHPEKTGVIRR-IDLLEKCFS-HDTVEEIIDSLE 283

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679 296 kfqqsSEASVAE--WANEAVQGIEKGAPFSLylthkyfsKVACaKGKTNNAMATLNGVMITEYRIALR---SALRSDFTE 370
Cdd:PLN02157 284 -----IEAGRRKdtWCITTLRRLKESSPLSL--------KVAL-RSIREGRLQTLDQCLIREYRMSLQgliGPMSGNFCE 349

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....
gi 145332679 371 GVRAVLTDKDQNPKWKPASLDEVDETEVDALFMPLSPEFEELNV 414
Cdd:PLN02157 350 GVRARLIDKDEAPKWDPPSLEKVSEDMVDDYFCALTPTEPDLDL 393
crotonase-like cd06558
Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse ...
 54-233 6.10e-46

Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. Many of these play important roles in fatty acid metabolism. In addition to a conserved structural core and the formation of trimers (or dimers of trimers), a common feature in this superfamily is the stabilization of an enolate anion intermediate derived from an acyl-CoA substrate. This is accomplished by two conserved backbone NH groups in active sites that form an oxyanion hole.


Pssm-ID: 119339 [Multi-domain]  Cd Length: 195  Bit Score: 156.95  E-value: 6.10e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679  54 NGVALITLDRPKALNAMNLEMDLKYKSLLDEWEYDPGVKCVVVEGStSRAFCAGGDVKQITSKNQLSDMI-EVFTAEYSL 132
Cdd:cd06558    7 GGVATITLNRPEKRNALSLEMLDELAAALDEAEADPDVRVVVLTGA-GKAFCAGADLKELAALSDAGEEArAFIRELQEL 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679 133 ICKIAGYRKPYISLMDGITMGFGLGLSGHGRYRVITERTVLAMPENGIGLFPDVGFSYIAAHSPGeGSVGAYLGMTGRRI 212
Cdd:cd06558   86 LRALLRLPKPVIAAVNGAALGGGLELALACDIRIAAEDAKFGLPEVKLGLVPGGGGTQRLPRLVG-PARARELLLTGRRI 164

                        170       180
                 ....*....|....*....|.
gi 145332679 213 StPSDALFVGLGTHYVPSGKL 233
Cdd:cd06558  165 S-AEEALELGLVDEVVPDEEL 184
CaiD COG1024
Enoyl-CoA hydratase/carnithine racemase [Lipid transport and metabolism]; Enoyl-CoA hydratase ...
 54-256 1.77e-41

Enoyl-CoA hydratase/carnithine racemase [Lipid transport and metabolism]; Enoyl-CoA hydratase/carnithine racemase is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440647 [Multi-domain]  Cd Length: 249  Bit Score: 146.85  E-value: 1.77e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679  54 NGVALITLDRPKALNAMNLEMDLKYKSLLDEWEYDPGVKCVVVEGStSRAFCAGGDVKQITSKNQLSDMIEVFTAEYSLI 133
Cdd:COG1024    7 GGVATITLNRPEKLNALSLEMLAELAAALDEAEADPDVRVVVLTGA-GKAFCAGADLKELAAAADPEEARAFARGLQRLF 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679 134 CKIAGYRKPYISLMDGITMGFGLGLSGHGRYRVITERTVLAMPENGIGLFPDVGFSYIAAHSPGEGsVGAYLGMTGRRIS 213
Cdd:COG1024   86 RALRRLPKPVIAAVNGAALGGGLELALACDLRIAAEDARFGLPEVRLGLIPGGGGTQRLPRLVGLA-RAKELLLTGRRID 164

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 145332679 214 tPSDALFVGLGTHYVPSGKLgsLREAI-LSADLSKDPQQHIQAT 256
Cdd:COG1024  165 -AEEALELGLVNRVVPDDEL--LAAALaLAARLAAGPPLALAAT 205
PRK06072 PRK06072
enoyl-CoA hydratase; Provisional
 55-193 3.05e-23

enoyl-CoA hydratase; Provisional


Pssm-ID: 168377 [Multi-domain]  Cd Length: 248  Bit Score: 97.54  E-value: 3.05e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679  55 GVALITLDRPKALNAMNLEMDLKYKSLLDEWEYDPGVKCVVVEGStSRAFCAGGDVKQItSKNQLSDMIEVFtaeYSLIC 134
Cdd:PRK06072   9 GYAIVTMSRPDKLNALNLEMRNEFISKLKQINADPKIRVVIVTGE-GRAFCVGADLSEF-APDFAIDLRETF---YPIIR 83

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 145332679 135 KIAGYRKPYISLMDGITMGFGLGLSGHGRYRVITERTVLAMPENGIGLFPDVGFSYIAA 193
Cdd:PRK06072  84 EIRFSDKIYISAINGVTAGACIGIALSTDFKFASRDVKFVTAFQRLGLASDTGVAYFLL 142
PRK06688 PRK06688
enoyl-CoA hydratase; Provisional
 54-233 4.53e-23

enoyl-CoA hydratase; Provisional


Pssm-ID: 235852 [Multi-domain]  Cd Length: 259  Bit Score: 97.25  E-value: 4.53e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679  54 NGVALITLDRPKALNAMNLEMdlkYKSL---LDEWEYDPGVKCVVVEGStSRAFCAGGDVKQITskNQLSDMIEVFTAEY 130
Cdd:PRK06688  13 DGVLTITINRPDKKNALTAAM---YQALadaLEAAATDPAVRVVVLTGA-GRAFSAGGDIKDFP--KAPPKPPDELAPVN 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679 131 SLICKIAGYRKPYISLMDGITMGFGLGLSGHGRYRVITERTVLAMPENGIGLFPDVGFSYIAAHSPGEgSVGAYLGMTGR 210
Cdd:PRK06688  87 RFLRAIAALPKPVVAAVNGPAVGVGVSLALACDLVYASESAKFSLPFAKLGLCPDAGGSALLPRLIGR-ARAAEMLLLGE 165

                        170       180
                 ....*....|....*....|...
gi 145332679 211 RISTPsDALFVGLGTHYVPSGKL 233
Cdd:PRK06688 166 PLSAE-EALRIGLVNRVVPAAEL 187
PRK07657 PRK07657
enoyl-CoA hydratase; Provisional
 45-240 9.93e-22

enoyl-CoA hydratase; Provisional


Pssm-ID: 181069 [Multi-domain]  Cd Length: 260  Bit Score: 93.65  E-value: 9.93e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679  45 EFVKGNVYPNGVALITLDRPKALNAMNLEMDLKYKSLLDEWEYDPGVKCVVVEGSTSRAFCAGGDVKQITSKNQlSDMIE 124
Cdd:PRK07657   3 QNISVDYVTPHVVKITLNRPRAANALSLALLEELQNILTQINEEANVRVVILTGAGEKAFCAGADLKERAGMNE-EQVRH 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679 125 VFTAEYSLICKIAGYRKPYISLMDGITMGFGLGLSGHGRYRVITERTVLAMPENGIGLFPDVGFSYIAAHSPGEGSVGAy 204
Cdd:PRK07657  82 AVSLIRTTMEMVEQLPQPVIAAINGIALGGGLELALACDFRIAAESASLGLTETTLAIIPGAGGTQRLPRLIGVGRAKE- 160

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 145332679 205 LGMTGRRISTpSDALFVGLGTHYVPSGKLGSLREAI 240
Cdd:PRK07657 161 LIYTGRRISA-QEAKEIGLVEFVVPAHLLEEKAIEI 195
ECH_1 pfam00378
Enoyl-CoA hydratase/isomerase; This family contains a diverse set of enzymes including: ...
 53-267 1.04e-19

Enoyl-CoA hydratase/isomerase; This family contains a diverse set of enzymes including: enoyl-CoA hydratase, napthoate synthase, carnitate racemase, 3-hydroxybutyryl-CoA dehydratase and dodecanoyl-CoA delta-isomerase.


Pssm-ID: 395302 [Multi-domain]  Cd Length: 251  Bit Score: 87.80  E-value: 1.04e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679   53 PNGVALITLDRPKALNAMNLEMDLKYKSLLDEWEYDPGVKCVVVEGStSRAFCAGGDVKQITSKNQLSDMIEVFTAeYSL 132
Cdd:pfam00378   3 NAGVAVITLNRPEAVNALSAELITELIQALEKLRTDPSVRAVVLTGG-DKAFCAGADLKEMYGEGPAHQALYRENV-LDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679  133 ICKIAGYRKPYISLMDGITMGFGLGLSGHGRYRVITERTVLAMPENGIGLFPDVGFSYIAAHSPGEgSVGAYLGMTGRRI 212
Cdd:pfam00378  81 WTLLYTCPKPVIAAVNGYAIGGGCELALACDIIIAADNASFGLNETKLGIIPGAGGTDRLPRIIGH-SKAMEMLLLGRRI 159

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 145332679  213 StPSDALFVGLGTHYVPSGKLgsLREAI-LSADLSKDPQQHIQATLSNY---SSDPETE 267
Cdd:pfam00378 160 S-AQEALKWGLVDKVVPEDQL--LDEAReLAEKLAEKSPAALAQLKKALnakLEDALPT 215
PRK05980 PRK05980
crotonase/enoyl-CoA hydratase family protein;
55-233 5.84e-17

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 180335 [Multi-domain]  Cd Length: 260  Bit Score: 80.19  E-value: 5.84e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679  55 GVALITLDRPKALNAMNLEMDLKYKSLLDEWEYDPGVKCVVVEGSTSRAFCAGGDVKQITSknQLSDMIEVFTAEY---- 130
Cdd:PRK05980  12 GIALLTLNRPEKLNALNYALIDRLLARLDAIEVDESVRAVILTGAGDRAFSAGADIHEFSA--SVAAGADVALRDFvrrg 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679 131 -SLICKIAGYRKPYISLMDGITMGFGLGLSGHGRYRVITERTVLAMPENGIGLFPDVGFSYIAAHSPGEGSVGAYLgMTG 209
Cdd:PRK05980  90 qAMTARLEAFPKPVIAAVNGLAFGGGCEITEAVHLAIASERALFAKPEIRLGMPPTFGGTQRLPRLAGRKRALELL-LTG 168

                        170       180
                 ....*....|....*....|....
gi 145332679 210 RRIStPSDALFVGLGTHYVPSGKL 233
Cdd:PRK05980 169 DAFS-AERALEIGLVNAVVPHEEL 191
PRK07659 PRK07659
enoyl-CoA hydratase; Provisional
 51-198 1.76e-16

enoyl-CoA hydratase; Provisional


Pssm-ID: 236073 [Multi-domain]  Cd Length: 260  Bit Score: 78.92  E-value: 1.76e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679  51 VYPNGVALITLDRPKALNAMNLEMDLKYKSLLDEWEyDPGVKCVVVEGStSRAFCAGGDVKQITSKNQLSDMIEVFTAEY 130
Cdd:PRK07659  11 KYEGRVATIMLNRPEALNALDEPMLKELLQALKEVA-ESSAHIVVLRGN-GRGFSAGGDIKMMLSSNDESKFDGVMNTIS 88

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 145332679 131 SLICKIAGYRKPYISLMDGITMGFGLGLSGHGRYRVITERTVLAMPENGIGLFPDVGFSYIAAHSPGE 198
Cdd:PRK07659  89 EIVVTLYTMPKLTISAIHGPAAGLGLSIALTADYVIADISAKLAMNFIGIGLIPDGGGHFFLQKRVGE 156
PRK07658 PRK07658
enoyl-CoA hydratase; Provisional
 55-321 3.48e-16

enoyl-CoA hydratase; Provisional


Pssm-ID: 181070 [Multi-domain]  Cd Length: 257  Bit Score: 77.75  E-value: 3.48e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679  55 GVALITLDRPKAlNAMNLEMDLKYKSLLDEWEYDPGVKCVVVEGStSRAFCAGGDVKQITSKNQLSDMIEVFTAEYSLIC 134
Cdd:PRK07658  11 HVAVITLNHPPA-NALSSQVLHELSELLDQVEKDDNVRVVVIHGE-GRFFSAGADIKEFTSVTEAEQATELAQLGQVTFE 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679 135 KIAGYRKPYISLMDGITMGFGLGLSGHGRYRVITERTVLAMPENGIGLFPdvGFS-------YIaahspgeGSVGAYLGM 207
Cdd:PRK07658  89 RVEKFSKPVIAAIHGAALGGGLELAMSCHIRFATESAKLGLPELNLGLIP--GFAgtqrlprYV-------GKAKALEMM 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679 208 -TGRRIsTPSDALFVGLGTHYVPSGKLgsLREAI-LSADLSKDPQQHIQATLSnyssdpeteshlqmLLPqiesaFSVSK 285
Cdd:PRK07658 160 lTSEPI-TGAEALKWGLVNGVFPEETL--LDDAKkLAKKIAGKSPATTRAVLE--------------LLQ-----TTKSS 217

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 145332679 286 SVKETIE-ELKKFqqsSEASVAEWANEAVQG-IEKGAP 321
Cdd:PRK07658 218 SYYEGVKrEAKIF---GEVFTSEDAKEGVQAfLEKRKP 252
PLN02600 PLN02600
enoyl-CoA hydratase
 54-231 3.93e-16

enoyl-CoA hydratase


Pssm-ID: 178210 [Multi-domain]  Cd Length: 251  Bit Score: 77.54  E-value: 3.93e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679  54 NGVALITLDRPKALNAMNLEMDLKYKSLLDEWEYDPGVKCVVVEGSTSRAFCAGGDVKQiTSKNQLSDMIEVFTAEYSLI 133
Cdd:PLN02600   3 SGIVELRLDRPEAKNAIGKEMLRGLRSAFEKIQADASARVVMLRSSVPGVFCAGADLKE-RRKMSPSEVQKFVNSLRSTF 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679 134 CKIAGYRKPYISLMDGITMGFGLGLSGHGRYRVITERTVLAMPENGIGLFPDVGFSYIAAHSPGEgSVGAYLGMTGRRIS 213
Cdd:PLN02600  82 SSLEALSIPTIAVVEGAALGGGLELALSCDLRICGEEAVFGLPETGLAIIPGAGGTQRLPRLVGR-SRAKELIFTGRRIG 160

                        170
                 ....*....|....*...
gi 145332679 214 TpSDALFVGLGTHYVPSG 231
Cdd:PLN02600 161 A-REAASMGLVNYCVPAG 177
PRK06494 PRK06494
enoyl-CoA hydratase; Provisional
 55-233 4.48e-16

enoyl-CoA hydratase; Provisional


Pssm-ID: 180591 [Multi-domain]  Cd Length: 259  Bit Score: 77.39  E-value: 4.48e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679  55 GVALITLDRPKALNAMNLEMDLKYKSLLDEWEYDPGVKCVVVEGSTSRAFCAGGDVKQITSKNQLSDMIEVF---TAEYS 131
Cdd:PRK06494  13 HVTIVTLNRPEVMNALHLDAHFELEEVFDDFAADPEQWVAIVTGAGDKAFSAGNDLKEQAAGGKRGWPESGFgglTSRFD 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679 132 LickiagyRKPYISLMDGITMGFGLGLSGHGRYRVITERTVLAMPENGIGLFPDVGfsyiAAHS-PGEGSVGAYLGM--T 208
Cdd:PRK06494  93 L-------DKPIIAAVNGVAMGGGFELALACDLIVAAENATFALPEPRVGLAALAG----GLHRlPRQIGLKRAMGMilT 161

                        170       180
                 ....*....|....*....|....*
gi 145332679 209 GRRISTPsDALFVGLGTHYVPSGKL 233
Cdd:PRK06494 162 GRRVTAR-EGLELGFVNEVVPAGEL 185
PRK06190 PRK06190
enoyl-CoA hydratase; Provisional
 55-260 1.19e-15

enoyl-CoA hydratase; Provisional


Pssm-ID: 235733  Cd Length: 258  Bit Score: 76.17  E-value: 1.19e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679  55 GVALITLDRPKALNAMNLEMDLKYKSLLDEWEYDPGVKCVVVEGStSRAFCAGGDVKQITsknqlSDMIEVF--TAEYSL 132
Cdd:PRK06190  13 RVRTLTLNRPEARNALSAALRRALFAALAEADADDDVDVVVLTGA-DPAFCAGLDLKELG-----GDGSAYGaqDALPNP 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679 133 ICKIAGYRKPYISLMDG--ITMGFGLGLsgHGRYRVITERTVLAMPENGIGLFPDVGFSyiaAHSPgeGSVGAY----LG 206
Cdd:PRK06190  87 SPAWPAMRKPVIGAINGaaVTGGLELAL--ACDILIASERARFADTHARVGILPGWGLS---VRLP--QKVGIGrarrMS 159

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 145332679 207 MTGRRIStPSDALFVGLGTHYVPSGKLgsLREAI-LSADLSKDPQQHIQATLSNY 260
Cdd:PRK06190 160 LTGDFLD-AADALRAGLVTEVVPHDEL--LPRARrLAASIAGNNPAAVRALKASY 211
PRK05809 PRK05809
short-chain-enoyl-CoA hydratase;
55-187 3.96e-15

short-chain-enoyl-CoA hydratase;


Pssm-ID: 180270 [Multi-domain]  Cd Length: 260  Bit Score: 74.78  E-value: 3.96e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679  55 GVALITLDRPKALNAMNLEMDLKYKSLLDEWEYDPGVKCVVVEGSTSRAFCAGGDVkqitskNQLSDMIEVFTAEYSLIC 134
Cdd:PRK05809  13 HIAVVTINRPKALNALNSETLKELDTVLDDIENDDNVYAVILTGAGEKAFVAGADI------SEMKDLNEEEGRKFGLLG 86

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 145332679 135 -----KIAGYRKPYISLMDGITMGFGLGLSGHGRYRVITERTVLAMPENGIGLFPDVG 187
Cdd:PRK05809  87 nkvfrKLENLDKPVIAAINGFALGGGCELSMACDIRIASEKAKFGQPEVGLGITPGFG 144
PRK08138 PRK08138
enoyl-CoA hydratase; Provisional
 39-223 2.67e-14

enoyl-CoA hydratase; Provisional


Pssm-ID: 236162 [Multi-domain]  Cd Length: 261  Bit Score: 72.39  E-value: 2.67e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679  39 MASGSDEFVKGNVYPNGVALITLDRPKALNAMNLEMDLKYKSLLDEWEYDPGVKCVVVEGsTSRAFCAGGDVKQITSknq 118
Cdd:PRK08138   1 MMSTATDVVLLERPADGVALLRLNRPEARNALNMEVRQQLAEHFTELSEDPDIRAIVLTG-GEKVFAAGADIKEFAT--- 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679 119 lSDMIEVFT--AEYsLICKIAGYRKPYISLMDGITMGFGLGLSGHGRYRVITERTVLAMPENGIGLFPDVGfsyiaahsp 196
Cdd:PRK08138  77 -AGAIEMYLrhTER-YWEAIAQCPKPVIAAVNGYALGGGCELAMHADIIVAGESASFGQPEIKVGLMPGAG--------- 145

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 145332679 197 geGS------VGAY----LGMTGRRISTPsDALFVGL 223
Cdd:PRK08138 146 --GTqrlvraVGKFkamrMALTGCMVPAP-EALAIGL 179
PRK05862 PRK05862
enoyl-CoA hydratase; Provisional
 56-243 3.58e-14

enoyl-CoA hydratase; Provisional


Pssm-ID: 180295 [Multi-domain]  Cd Length: 257  Bit Score: 72.00  E-value: 3.58e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679  56 VALITLDRPKALNAMNLEMDLKYKSLLDEWEYDPGVKCVVVEGStSRAFCAGGDVKQITSKnqlsDMIEVFTAEY-SLIC 134
Cdd:PRK05862  14 VGLITLNRPKALNALNDALMDELGAALAAFDADEGIGAIVITGS-EKAFAAGADIKEMADL----SFMDVYKGDYiTNWE 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679 135 KIAGYRKPYISLMDGITMGFGLGLSGHGRYRVITERTVLAMPENGIGLFPDVGFSYIAAHSPGEgSVGAYLGMTGRRIST 214
Cdd:PRK05862  89 KVARIRKPVIAAVAGYALGGGCELAMMCDIIIAADTAKFGQPEIKLGVLPGMGGSQRLTRAVGK-AKAMDLCLTGRMMDA 167

                        170       180
                 ....*....|....*....|....*....
gi 145332679 215 pSDALFVGLGTHYVPSGKLgsLREAILSA 243
Cdd:PRK05862 168 -AEAERAGLVSRVVPADKL--LDEALAAA 193
PRK06127 PRK06127
enoyl-CoA hydratase; Provisional
 55-243 4.50e-14

enoyl-CoA hydratase; Provisional


Pssm-ID: 235705  Cd Length: 269  Bit Score: 72.05  E-value: 4.50e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679  55 GVALITLDRPKALNAMNLEMDLKYKSLLDEWEYDPGVKCVVVEGSTSRAFCAGGDVKQITSKNQLSDMIEVF----TAEY 130
Cdd:PRK06127  20 GLGRITFNNPARHNAMSLDMWEALPQALAAAEDDDAIRVVVLTGAGEKAFVSGADISQFEESRSDAEAVAAYeqavEAAQ 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679 131 SLIckiAGYRKPYISLMDGITMGFGLGLSGHGRYRVITERTVLAMPENGIGLfpdvGFSYIA----AHSPGEgSVGAYLG 206
Cdd:PRK06127 100 AAL---ADYAKPTIACIRGYCIGGGMGIALACDIRIAAEDSRFGIPAARLGL----GYGYDGvknlVDLVGP-SAAKDLF 171

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 145332679 207 MTGRRIsTPSDALFVGLGTHYVPSGKLGSLREAILSA 243
Cdd:PRK06127 172 YTARRF-DAAEALRIGLVHRVTAADDLETALADYAAT 207
PRK08139 PRK08139
enoyl-CoA hydratase; Validated
 54-189 5.69e-14

enoyl-CoA hydratase; Validated


Pssm-ID: 181249  Cd Length: 266  Bit Score: 71.51  E-value: 5.69e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679  54 NGVALITLDRPKALNAMNLEMDLKYKSLLDEWEYDPGVKCVVVEGsTSRAFCAGGDVKQITSKNQLSDMIEVFTAEYSLI 133
Cdd:PRK08139  19 DGVATLTLNRPQAFNALSEAMLAALQAALDAIAADPSVRVVVLAA-AGKAFCAGHDLKEMRAARGLAYFRALFARCSRVM 97

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 145332679 134 CKIAGYRKPYISLMDGITMGFGLGLSGHGRYRVITERTVLAMPENGIGLF---PDVGFS 189
Cdd:PRK08139  98 QAIVALPQPVIARVHGIATAAGCQLVASCDLAVAADTARFAVPGVNIGLFcstPMVALS 156
PRK06210 PRK06210
enoyl-CoA hydratase; Provisional
 51-275 5.72e-13

enoyl-CoA hydratase; Provisional


Pssm-ID: 180472  Cd Length: 272  Bit Score: 68.58  E-value: 5.72e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679  51 VYPNGVALITLDRPKALNAMNLEMDLKYKSLLDEWEYDPGVKCVVVEGStSRAFCAGGDV--------KQITSKNQLSDM 122
Cdd:PRK06210  11 VADSGVAVITLNRPDRLNAWTPVMEAEVYAAMDRAEADPAVRVIVLTGA-GRGFCAGADMgelqtidpSDGRRDTDVRPF 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679 123 I----EVFTAEYSLICKIagyRKPYISLMDGITMGFGLGLSGHGRYRVITERTVLAMPENGIGLFPDVGFSYIAAHSPGE 198
Cdd:PRK06210  90 VgnrrPDYQTRYHFLTAL---RKPVIAAINGACAGIGLTHALMCDVRFAADGAKFTTAFARRGLIAEHGISWILPRLVGH 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679 199 GsVGAYLGMTGRRISTpSDALFVGLGTHYVPSGKL----GSLRE-----------AILSADLSKDPQQhiqaTLSNYSSD 263
Cdd:PRK06210 167 A-NALDLLLSARTFYA-EEALRLGLVNRVVPPDELmertLAYAEdlarnvspasmAVIKRQLYEDAFQ----TLAEATAR 240

                        250
                 ....*....|..
gi 145332679 264 PETESHLQMLLP 275
Cdd:PRK06210 241 ANREMHESLQRP 252
PRK06144 PRK06144
enoyl-CoA hydratase; Provisional
 54-176 1.16e-12

enoyl-CoA hydratase; Provisional


Pssm-ID: 180424 [Multi-domain]  Cd Length: 262  Bit Score: 67.71  E-value: 1.16e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679  54 NGVALITLDRPKALNAMNLEMDLKYKSLLDEWEYDPGVKCVVVEGSTSRAFCAGGDVKQITSKNQLSDMIEVFTAEYSLI 133
Cdd:PRK06144  16 GGIARITFNRPAARNAMTWAMYEGLAEICEAIAADPSIRAVVLRGAGDKAFVAGTDIAQFRAFSTAEDAVAYERRIDRVL 95

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 145332679 134 CKIAGYRKPYISLMDGITMGFGLGLSGHGRYRVITERTVLAMP 176
Cdd:PRK06144  96 GALEQLRVPTIAAIAGACVGGGAAIAAACDLRIATPSARFGFP 138
PRK07799 PRK07799
crotonase/enoyl-CoA hydratase family protein;
58-245 1.25e-11

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 181122 [Multi-domain]  Cd Length: 263  Bit Score: 64.74  E-value: 1.25e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679  58 LITLDRPKALNAMNLEMDLKYKSLLDEWEYDPGVKCVVVEGSTSrAFCAGGDVKQITSKNQLSDMIEVFTAEYSLICKIA 137
Cdd:PRK07799  17 IVTMNRPEARNALSTEMLRIMVDAWDRVDNDPDIRSCILTGAGG-AFCAGMDLKAATKKPPGDSFKDGSYDPSRIDALLK 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679 138 GYR--KPYISLMDGITMGFGLGLSGHGRYRVITERTVLAMPENGIGLFPdVGFSYIAAHSPGEGSVGAYLGMTGRRISTP 215
Cdd:PRK07799  96 GRRltKPLIAAVEGPAIAGGTEILQGTDIRVAGESAKFGISEAKWSLFP-MGGSAVRLVRQIPYTVACDLLLTGRHITAA 174

                        170       180       190
                 ....*....|....*....|....*....|
gi 145332679 216 sDALFVGLGTHYVPSGKlgSLREAILSADL 245
Cdd:PRK07799 175 -EAKEIGLIGHVVPDGQ--ALDKALELAEL 201
fa_ox_alpha_mit TIGR02441
fatty acid oxidation complex, alpha subunit, mitochondrial; Members represent alpha subunit of ...
 54-212 1.25e-11

fatty acid oxidation complex, alpha subunit, mitochondrial; Members represent alpha subunit of mitochondrial multifunctional fatty acid degradation enzyme complex. Subunit activities include: enoyl-CoA hydratase (EC 4.2.1.17) _ 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35). Some characterization in human (SP:P40939), pig (SP:Q29554), and rat (SP:Q64428). The beta subunit has activity: acetyl-CoA C-acyltransferase (EC 2.3.1.16).


Pssm-ID: 131494 [Multi-domain]  Cd Length: 737  Bit Score: 66.40  E-value: 1.25e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679   54 NGVALITLDRPKA-LNAMNLEMDLKYKSLLDEWEYDPGVKCVVVEGSTSRAFCAGGDVKQITSKNQLSDMIEVFTAEYSL 132
Cdd:TIGR02441  21 GDVAVVKIDSPNSkVNTLSKELFAEFKEVMNELWTNEAIKSAVLISGKPGSFVAGADIQMIAACKTAQEVTQLSQEGQEM 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679  133 ICKIAGYRKPYISLMDGITMGFGLGLSGHGRYRVITE--RTVLAMPENGIGLFPDVGFSyiaAHSPGEGSVGAYLGM--T 208
Cdd:TIGR02441 101 FERIEKSQKPIVAAISGSCLGGGLELALACHYRIATKdrKTLLGLPEVMLGLLPGAGGT---QRLPKLTGVPAALDMmlT 177


                  ....
gi 145332679  209 GRRI 212
Cdd:TIGR02441 178 GKKI 181
PRK09674 PRK09674
enoyl-CoA hydratase-isomerase; Provisional
 55-187 1.44e-11

enoyl-CoA hydratase-isomerase; Provisional


Pssm-ID: 182026 [Multi-domain]  Cd Length: 255  Bit Score: 64.40  E-value: 1.44e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679  55 GVALITLDRPKALNAMNLEMDLKYKSLLDEWEYDPGVKCVVVEGStSRAFCAGGDVKQITSKnqlsDMIEVFT-AEYSLI 133
Cdd:PRK09674  11 RVLLLTLNRPEARNALNNALLTQLVNELEAAATDTSIGVCVITGN-ARFFAAGADLNEMAEK----DLAATLNdPRPQLW 85

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 145332679 134 CKIAGYRKPYISLMDGITMGFGLGLSGHGRYRVITERTVLAMPENGIGLFPDVG 187
Cdd:PRK09674  86 QRLQAFNKPLIAAVNGYALGAGCELALLCDIVIAGENARFGLPEITLGIMPGAG 139
PRK05864 PRK05864
enoyl-CoA hydratase; Provisional
 55-233 5.76e-11

enoyl-CoA hydratase; Provisional


Pssm-ID: 168278 [Multi-domain]  Cd Length: 276  Bit Score: 62.93  E-value: 5.76e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679  55 GVALITLDRPKALNAMNLEMDLKYKSLLDEWEYDPGVKCVVVEGStSRAFCAGGDVKQITSKNQLSDMIEVFTAEYSL-- 132
Cdd:PRK05864  19 EIALITLNRPERMNSMAFDVMVPLKEALAEVSYDNSVRVVVLTGA-GRGFSSGADHKSAGVVPHVEGLTRPTYALRSMel 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679 133 ----ICKIAGYRKPYISLMDGITMGFGLGLSGHGRYRVITERTVL--AMPENGIGLfPDVGFSYIAAHSPGEgSVGAYLG 206
Cdd:PRK05864  98 lddvILALRRLHQPVIAAVNGPAIGGGLCLALAADIRVASSSAYFraAGINNGLTA-SELGLSYLLPRAIGS-SRAFEIM 175

                        170       180
                 ....*....|....*....|....*..
gi 145332679 207 MTGRRIsTPSDALFVGLGTHYVPSGKL 233
Cdd:PRK05864 176 LTGRDV-DAEEAERIGLVSRQVPDEQL 201
PRK08258 PRK08258
enoyl-CoA hydratase family protein;
54-249 1.15e-10

enoyl-CoA hydratase family protein;


Pssm-ID: 181329  Cd Length: 277  Bit Score: 61.91  E-value: 1.15e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679  54 NGVALITLDRPKALNAMNLEMDLKYKSLLDEWEYDPGVKCVVVEGStSRAFCAGGDVKQITSKNQLSDMIEV--FT-AEY 130
Cdd:PRK08258  25 DGVATITLNRPERKNPLTFESYAELRDLFRELVYADDVKAVVLTGA-GGNFCSGGDVHEIIGPLTKMDMPELlaFTrMTG 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679 131 SLICKIAGYRKPYISLMDGITMGFGLGLSGHGRYRVITERTVLAMPENGIGLF-PDVGFSYIAAHSPGEGSvGAYLGMTG 209
Cdd:PRK08258 104 DLVKAMRACPQPIIAAVDGVCAGAGAILAMASDLRLGTPSAKTAFLFTRVGLAgADMGACALLPRIIGQGR-ASELLYTG 182

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 145332679 210 RRISTPsDALFVGLGTHYVPSGKLgsLREA-ILSADLSKDP 249
Cdd:PRK08258 183 RSMSAE-EGERWGFFNRLVEPEEL--LAEAqALARRLAAGP 220
PRK07327 PRK07327
enoyl-CoA hydratase/isomerase family protein;
53-156 1.60e-10

enoyl-CoA hydratase/isomerase family protein;


Pssm-ID: 235991  Cd Length: 268  Bit Score: 61.19  E-value: 1.60e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679  53 PNGVALITLDRPKALNAMNLEMdlkYKSLLDEW---EYDPGVKCVVVEGStSRAFCAGGDVKQItsknqlSDMIEVFTAE 129
Cdd:PRK07327  19 PPGVLEIVLNGPGALNAADARM---HRELADIWrdvDRDPDVRVVLIRGE-GKAFSAGGDLALV------EEMADDFEVR 88

                         90       100       110
                 ....*....|....*....|....*....|....
gi 145332679 130 Y-------SLICKIAGYRKPYISLMDGITMGFGL 156
Cdd:PRK07327  89 ArvwrearDLVYNVINCDKPIVSAIHGPAVGAGL 122
PRK08140 PRK08140
enoyl-CoA hydratase; Provisional
 55-155 2.20e-10

enoyl-CoA hydratase; Provisional


Pssm-ID: 236163  Cd Length: 262  Bit Score: 60.70  E-value: 2.20e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679  55 GVALITLDRPKALNAMNLEMDLKYKSLLDEWEyDPGVKCVVVEGStSRAFCAGGDV--KQITSKNQLSDMIEVFTAEYS- 131
Cdd:PRK08140  13 GVATLTLNRPDKLNSFTREMHRELREALDQVE-DDGARALLLTGA-GRGFCAGQDLadRDVTPGGAMPDLGESIETFYNp 90

                         90       100
                 ....*....|....*....|....
gi 145332679 132 LICKIAGYRKPYISLMDGITMGFG 155
Cdd:PRK08140  91 LVRRLRALPLPVIAAVNGVAAGAG 114
PRK07509 PRK07509
crotonase/enoyl-CoA hydratase family protein;
54-226 4.19e-10

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 181008 [Multi-domain]  Cd Length: 262  Bit Score: 59.89  E-value: 4.19e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679  54 NGVALITLDRPKALNAMNLEMdlkYKSLLD---EWEYDPGVKCVVVEGsTSRAFCAGGDVKQITS--KNQLSDMIEVFTA 128
Cdd:PRK07509  11 DGIADVRLNRPDKMNALDFAM---FEELIAtikRLKKDRGIRAVILSG-EGGAFCAGLDVKSVASspGNAVKLLFKRLPG 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679 129 EYSLICKIA-GYRK---PYISLMDGITMGFGLGLSGHGRYRVITERTVLAMPENGIGLFPDVGfsyiaahspgeGSVGA- 203
Cdd:PRK07509  87 NANLAQRVSlGWRRlpvPVIAALEGVCFGGGLQIALGADIRIAAPDTKLSIMEAKWGLVPDMA-----------GTVSLr 155

                        170       180       190
                 ....*....|....*....|....*....|..
gi 145332679 204 ---------YLGMTGRRIStPSDALFVGLGTH 226
Cdd:PRK07509 156 glvrkdvarELTYTARVFS-AEEALELGLVTH 186
PRK09076 PRK09076
enoyl-CoA hydratase; Provisional
 56-243 6.90e-10

enoyl-CoA hydratase; Provisional


Pssm-ID: 236373 [Multi-domain]  Cd Length: 258  Bit Score: 59.16  E-value: 6.90e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679  56 VALITLDRPKAlNAMNLEMDLKYKSLLDEWEYDPGVKCVVVEGSTSRAFCAGGDVKQITS--KNQLSDMIEVFTAEYSli 133
Cdd:PRK09076  13 VAILTLNNPPA-NTWTADSLQALKQLVLELNADKDVYALVITGDGEKFFSAGADLNLFADgdKAVAREMARRFGEAFE-- 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679 134 cKIAGYRKPYISLMDGITMGFGLGLSGHGRYRVITERTVLAMPENGIGLFPDVGFSYIAAHSPGEGSVGAYLgMTGRRIS 213
Cdd:PRK09076  90 -ALSAFRGVSIAAINGYAMGGGLECALACDIRIAEEQAQMALPEASVGLLPCAGGTQNLPWLVGEGWAKRMI-LCGERVD 167

                        170       180       190
                 ....*....|....*....|....*....|
gi 145332679 214 TPSdALFVGLGTHYVPSGKlgSLREAILSA 243
Cdd:PRK09076 168 AAT-ALRIGLVEEVVEKGE--AREAALALA 194
PRK08260 PRK08260
enoyl-CoA hydratase; Provisional
 54-109 8.09e-10

enoyl-CoA hydratase; Provisional


Pssm-ID: 236206 [Multi-domain]  Cd Length: 296  Bit Score: 59.63  E-value: 8.09e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 145332679  54 NGVALITLDRPKALNAMNLEMDLKYKSLLDEWEYDPGVKCVVVEGStSRAFCAGGD 109
Cdd:PRK08260  12 DGIATITLNRPDKLNAFTVTMARELIEAFDAADADDAVRAVIVTGA-GRAFCAGAD 66
PLN02888 PLN02888
enoyl-CoA hydratase
 53-158 1.07e-09

enoyl-CoA hydratase


Pssm-ID: 215480  Cd Length: 265  Bit Score: 59.00  E-value: 1.07e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679  53 PNGVALITLDRPKALNAMNLEMDLKYKSLLDEWEYDPGVKCVVVEGStSRAFCAGGDvkqitsknqLSDMIEVF-----T 127
Cdd:PLN02888  17 RNGIATITINRPKALNALTRPMMVELAAAFKRLDEDDSVKVIILTGS-GRAFCSGVD---------LTAAEEVFkgdvkD 86

                         90       100       110
                 ....*....|....*....|....*....|...
gi 145332679 128 AEYSLICKIAGYRKPYISLMDG--ITMGFGLGL 158
Cdd:PLN02888  87 VETDPVAQMERCRKPIIGAINGfaITAGFEIAL 119
PRK07511 PRK07511
enoyl-CoA hydratase; Provisional
 55-213 1.67e-09

enoyl-CoA hydratase; Provisional


Pssm-ID: 181009 [Multi-domain]  Cd Length: 260  Bit Score: 58.08  E-value: 1.67e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679  55 GVALITLDRPKALNAMNLEMdlkYKSL---LDEWEYDPGVKCVVVEGStSRAFCAGGDVKQITSKNQL--SDMIEVFTAE 129
Cdd:PRK07511  12 STLVLTLSNPGARNALHPDM---YAAGieaLNTAERDPSIRAVVLTGA-GGFFCAGGNLNRLLENRAKppSVQAASIDGL 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679 130 YSLICKIAGYRKPYISLMDGITMGFGLGLSGHGRYRVITERTVLAMPENGIGLFPDVGFSYIAAHS-PGEgsVGAYLGMT 208
Cdd:PRK07511  88 HDWIRAIRAFPKPVIAAVEGAAAGAGFSLALACDLLVAARDAKFVMAYVKVGLTPDGGGSWFLARAlPRQ--LATELLLE 165


                 ....*
gi 145332679 209 GRRIS 213
Cdd:PRK07511 166 GKPIS 170
PRK05995 PRK05995
enoyl-CoA hydratase; Provisional
 52-250 2.09e-09

enoyl-CoA hydratase; Provisional


Pssm-ID: 235664 [Multi-domain]  Cd Length: 262  Bit Score: 58.01  E-value: 2.09e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679  52 YPNGVALITLDRPKALNAMNLEMDLKYKSLLDEWEYDPGVKCVVVEGsTSRAFCAGGDVKQIT-------SKN-----QL 119
Cdd:PRK05995  10 QRGQVATVTLNRPDVRNAFNETVIAELTAAFRALDADDSVRAVVLAG-AGKAFCAGADLNWMKkmagysdDENradarRL 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679 120 SDMIEVftaeyslickIAGYRKPYISLMDGITMGFGLGLSGHGRYRVITERTVLAMPENGIGLFPDVGFSYIaAHSPGEG 199
Cdd:PRK05995  89 ADMLRA----------IYRCPKPVIARVHGDAYAGGMGLVAACDIAVAADHAVFCLSEVRLGLIPATISPYV-IRAMGER 157

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 145332679 200 SVGAYLgMTGRRIsTPSDALFVGLGTHYVPSGKLGSLREAILSADLSKDPQ 250
Cdd:PRK05995 158 AARRYF-LTAERF-DAAEALRLGLVHEVVPAEALDAKVDELLAALVANSPQ 206
PRK03580 PRK03580
crotonobetainyl-CoA hydratase;
54-233 3.65e-09

crotonobetainyl-CoA hydratase;


Pssm-ID: 179599 [Multi-domain]  Cd Length: 261  Bit Score: 57.01  E-value: 3.65e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679  54 NGVALITLDRPKAlNAMNL----EMDLKYKSLLDeweyDPGVKCVVVEGSTSRAFCAGGDVKQITSknqlSDMIEvftAE 129
Cdd:PRK03580  11 GSILEITLDRPKA-NAIDAktsfAMGEVFLNFRD----DPELRVAIITGAGEKFFSAGWDLKAAAE----GEAPD---AD 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679 130 YSL-----ICKIAGYRKPYISLMDGITMGFGLGLSGHGRYRVITERTVLAMPENGIGLFPDVGF-----SYIAAHspgeg 199
Cdd:PRK03580  79 FGPggfagLTEIFDLDKPVIAAVNGYAFGGGFELALAADFIVCADNASFALPEAKLGIVPDSGGvlrlpKRLPPA----- 153

                        170       180       190
                 ....*....|....*....|....*....|....
gi 145332679 200 sVGAYLGMTGRRIStPSDALFVGLGTHYVPSGKL 233
Cdd:PRK03580 154 -IANEMVMTGRRMD-AEEALRWGIVNRVVPQAEL 185
PRK07827 PRK07827
enoyl-CoA hydratase family protein;
55-186 6.64e-09

enoyl-CoA hydratase family protein;


Pssm-ID: 236109 [Multi-domain]  Cd Length: 260  Bit Score: 56.23  E-value: 6.64e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679  55 GVALITLDRPKALNAMNLEMDLKYKSLLDEWEYDPGVKCVVVeGSTSRAFCAGGDVKQITSKNQLSDMIEVFTAE--YSL 132
Cdd:PRK07827  15 GVATLTLDSPHNRNALSARLVAQLHDGLRAAAADPAVRAVVL-THTGGTFCAGADLSEAGGGGGDPYDAAVARARemTAL 93

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 145332679 133 ICKIAGYRKPYISLMDGITMGFGLGLSGHGRYRVITERTVLAMPENGIGLFPDV 186
Cdd:PRK07827  94 LRAIVELPKPVIAAIDGHVRAGGFGLVGACDIVVAGPESTFALTEARIGVAPAI 147
PRK06495 PRK06495
enoyl-CoA hydratase/isomerase family protein;
55-182 7.16e-09

enoyl-CoA hydratase/isomerase family protein;


Pssm-ID: 168580 [Multi-domain]  Cd Length: 257  Bit Score: 56.24  E-value: 7.16e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679  55 GVALITLDRPkALNAMNLEMDLKYKSLLDEWEYDPGVKCVVVEGsTSRAFCAGGDVK----------QITSKNQLSDmiE 124
Cdd:PRK06495  13 HVAVVTLDNP-PVNALSRELRDELIAVFDEISERPDVRVVVLTG-AGKVFCAGADLKgrpdvikgpgDLRAHNRRTR--E 88

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 145332679 125 VFTAeyslickIAGYRKPYISLMDGITMGFGLGLSGHGRYRVITERTVLAMPENGIGL 182
Cdd:PRK06495  89 CFHA-------IRECAKPVIAAVNGPALGAGLGLVASCDIIVASENAVFGLPEIDVGL 139
PRK08272 PRK08272
crotonase/enoyl-CoA hydratase family protein;
55-111 1.29e-08

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 236213  Cd Length: 302  Bit Score: 55.82  E-value: 1.29e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 145332679  55 GVALITLDRPKALNAMNLEMDLKYKSLLDEWEYDPGVKCVVVEGsTSRAFCAGGDVK 111
Cdd:PRK08272  19 RIARITLNRPEKGNAITADTPLELRAAVERADLDPGVHVILVSG-AGKGFCAGYDLS 74
PRK05870 PRK05870
enoyl-CoA hydratase; Provisional
 53-282 1.65e-08

enoyl-CoA hydratase; Provisional


Pssm-ID: 180298  Cd Length: 249  Bit Score: 55.12  E-value: 1.65e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679  53 PNGVALITLDRPKALNAMNLEMDLKYKSLLDEWEYDPGVKCVVVEGsTSRAFCAGGDVKQITSKNQLSDMiEVFTAEYSL 132
Cdd:PRK05870  10 DDGVALITVNDPDRRNAVTAEMSAQLRAAVAAAEADPDVHALVVTG-AGKAFCAGADLTALGAAPGRPAE-DGLRRIYDG 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679 133 ICKIAGYRKPYISLMDGITMGFGLGLSGHGRYRVITERTVLAMPENGIGLFPDVGFSYIAAHSPGEGSVGAYLgMTGRRI 212
Cdd:PRK05870  88 FLAVASCPLPTIAAVNGAAVGAGLNLALAADVRIAGPKALFDARFQKLGLHPGGGATWMLQRAVGPQVARAAL-LFGMRF 166

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 145332679 213 STPSdALFVGLGTHYV--PSGKLGSLREAILSAD--LSKDPQQHIQATLSNYSSDPETESHLQmllPQIESAFS 282
Cdd:PRK05870 167 DAEA-AVRHGLALMVAddPVAAALELAAGPAAAPreLVLATKASMRATASLAQHAAAVEFELG---PQAASVQS 236
PRK05981 PRK05981
enoyl-CoA hydratase/isomerase;
55-272 1.81e-08

enoyl-CoA hydratase/isomerase;


Pssm-ID: 235661  Cd Length: 266  Bit Score: 55.12  E-value: 1.81e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679  55 GVALITLDRPKALNAMNLEMDLKYKSLLDEWEYDP-GVKCVVVEGStSRAFCAGGDVKQITSKNQLSDMIE-----VFTA 128
Cdd:PRK05981  13 GVAILTLDHPEVMNAVSIDMLGGLAEALDAIEDGKaEVRCLVLTGA-GRGFCTGANLQGRGSGGRESDSGGdagaaLETA 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679 129 EYSLICKIAGYRKPYISLMDGITMGFGLGLSGHGRYRVITERTVLAMPENGIGLFPDVGFSYIAAHSPGEGSvGAYLGMT 208
Cdd:PRK05981  92 YHPFLRRLRNLPCPIVTAVNGPAAGVGMSFALMGDLILCARSAYFLQAFRRIGLVPDGGSTWLLPRLVGKAR-AMELSLL 170

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 145332679 209 GRRIstPSD-ALFVGLGTHYVPSGKLgsLREAI-LSADLSKDPQQHIQATLSNYSSDPETESHLQM 272
Cdd:PRK05981 171 GEKL--PAEtALQWGLVNRVVDDAEL--MAEAMkLAHELANGPTVALGLIRKLYWDSPENDFEEQL 232
PRK09120 PRK09120
p-hydroxycinnamoyl CoA hydratase/lyase; Validated
 54-249 1.84e-08

p-hydroxycinnamoyl CoA hydratase/lyase; Validated


Pssm-ID: 236383  Cd Length: 275  Bit Score: 55.01  E-value: 1.84e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679  54 NGVALITLDRPKALNAMNLEMDLKYKSLLDEWEYDPGVKCVVVEGSTSrAFCAGGDVKQItsknqlsdMIEVFTAEYSLI 133
Cdd:PRK09120  16 DGIAWVTLNRPEKRNAMSPTLNREMIDVLDALEFDDDAGVLVLTGAGD-AWSAGMDLKEY--------FRETDAQPEILQ 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679 134 CKI-----------AGYRKPYISLMDGITMGFGLGLSGHGRYRVITERTVLAMPENGIGLFPDVGFSYIAAHSPGEGSvG 202
Cdd:PRK09120  87 ERIrreaygwwrrlRWYQKPTIAMVNGWCFGGGFSPLVACDLAIAADEAQFGLSEINWGIPPGGGVSKAMADTVGHRD-A 165

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 145332679 203 AYLGMTGRRIsTPSDALFVGLGTHYVPSGKLGSLREAILSADLSKDP 249
Cdd:PRK09120 166 LYYIMTGETF-TGRKAAEMGLVNESVPLAQLRARTRELAAKLLEKNP 211
fadJ PRK11154
fatty acid oxidation complex subunit alpha FadJ;
50-187 2.85e-08

fatty acid oxidation complex subunit alpha FadJ;


Pssm-ID: 236864 [Multi-domain]  Cd Length: 708  Bit Score: 55.67  E-value: 2.85e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679  50 NVYPNGVALITLDRP-KALNAMNLEMDLKYKSLLDEWEYDPGVKCVVVEGSTSRAFCAGGDVKQITSKNQLSDMIEVFTA 128
Cdd:PRK11154  10 NVREDNIAVITIDVPgEKMNTLKAEFAEQVRAILKQLREDKELKGVVFISGKPDNFIAGADINMLAACKTAQEAEALARQ 89

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 145332679 129 EYSLICKIAGYRKPYISLMDGITMGFGLGLSGHGRYRVIT--ERTVLAMPENGIGLFPDVG 187
Cdd:PRK11154  90 GQQLFAEIEALPIPVVAAIHGACLGGGLELALACHYRVCTddPKTVLGLPEVQLGLLPGSG 150
PRK06023 PRK06023
crotonase/enoyl-CoA hydratase family protein;
55-207 7.09e-08

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 168351  Cd Length: 251  Bit Score: 53.26  E-value: 7.09e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679  55 GVALITLDRPKALNAMNLEMDLKYKSLLDEWEYDPGVKCVVVEGsTSRAFCAGgdvkqitskNQLSDMIEVFTAEYSLIC 134
Cdd:PRK06023  15 GVQVIRFNRPEKKNAITRAMYATMAKALKAADADDAIRAHVFLG-TEGCFSAG---------NDMQDFLAAAMGGTSFGS 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679 135 KI-------AGYRKPYISLMDGITMGFGLGLSGHGRYRVITERTVLAMPENGIGLFPDVGFSYIAAHSPGEGSVGAYLGM 207
Cdd:PRK06023  85 EIldflialAEAEKPIVSGVDGLAIGIGTTIHLHCDLTFASPRSLFRTPFVDLALVPEAGSSLLAPRLMGHQRAFALLAL 164
PRK08150 PRK08150
crotonase/enoyl-CoA hydratase family protein;
54-231 8.19e-08

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 181254  Cd Length: 255  Bit Score: 53.10  E-value: 8.19e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679  54 NGVALITLDRPKALNAMNLEMDLKYKSLLDEWEydPGVKCVVVEGSTSRaFCAGGDvkqitsknqLSDMIEVFTAEYSLI 133
Cdd:PRK08150  10 GGVATIGLNRPAKRNALNDGLIAALRAAFARLP--EGVRAVVLHGEGDH-FCAGLD---------LSELRERDAGEGMHH 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679 134 C--------KIAGYRKPYISLMDGITMGFGLGLSGHGRYRVITERTVLAMPENGIGLFpdVGfsyiaahspGEGSV---- 201
Cdd:PRK08150  78 SrrwhrvfdKIQYGRVPVIAALHGAVVGGGLELASAAHIRVADESTYFALPEGQRGIF--VG---------GGGSVrvpr 146

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 145332679 202 --GAY----LGMTGRRISTpSDALFVGLGTHYVPSG 231
Cdd:PRK08150 147 liGVArmtdMMLTGRVYDA-QEGERLGLAQYLVPAG 181
PRK08252 PRK08252
crotonase/enoyl-CoA hydratase family protein;
55-111 1.79e-07

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 181325 [Multi-domain]  Cd Length: 254  Bit Score: 51.91  E-value: 1.79e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 145332679  55 GVALITLDRPKALNAMNLEMDLKYKSLLDEWEYDPGVKCVVVEGSTSrAFCAGGDVK 111
Cdd:PRK08252  12 RVLIITINRPEARNAVNAAVAQGLAAALDELDADPDLSVGILTGAGG-TFCAGMDLK 67
PRK07468 PRK07468
crotonase/enoyl-CoA hydratase family protein;
55-250 5.25e-07

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 180987 [Multi-domain]  Cd Length: 262  Bit Score: 50.83  E-value: 5.25e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679  55 GVALITLDRPKALNAMNLEMDLKYKSLLDEWEYDPGVKCVVVEGsTSRAFCAGGDvkqitsknqLSDMIEVFTAEYSliC 134
Cdd:PRK07468  14 GVATLTLNRPEKHNALSARMIAELTTAARRLAADAAVRVVVLTG-AGKSFCAGGD---------LGWMRAQMTADRA--T 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679 135 KIAGYR-------------KPYISLMDGITMGFGLGLSGHGRYRVITERTVLAMPENGIGLFPDVGFSYIAAHSpGEGSV 201
Cdd:PRK07468  82 RIEEARrlammlkalndlpKPLIGRIQGQAFGGGVGLISVCDVAIAVSGARFGLTETRLGLIPATISPYVVARM-GEANA 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 145332679 202 GAyLGMTGRRISTpSDALFVGLGTHYVPSGKLGSLREAILSADLSKDPQ 250
Cdd:PRK07468 161 RR-VFMSARLFDA-EEAVRLGLLSRVVPAERLDAAVEAEVTPYLSCAPG 207
PRK09245 PRK09245
crotonase/enoyl-CoA hydratase family protein;
55-233 8.90e-07

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 181723  Cd Length: 266  Bit Score: 49.97  E-value: 8.90e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679  55 GVALITLDRPKALNAMNLEMDL-KYKSLLDEWEYDPGVKCVVVEGSTSrAFCAGGDVKqitsknqlsDMIEVFTAEYSLI 133
Cdd:PRK09245  12 HIVTLTMNRPETRNALSDNDAVdALVAACAAINADRSVRAVILTGAGT-AFSSGGNVK---------DMRARVGAFGGSP 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679 134 CKI-AGYRK--------------PYISLMDGITMGFGLGLSGHGRYRVITERTVLAMPENGIGLFpdvgfsyiaahsPGE 198
Cdd:PRK09245  82 ADIrQGYRHgiqriplalynlevPVIAAVNGPAIGAGCDLACMCDIRIASETARFAESFVKLGLI------------PGD 149

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 145332679 199 GsvGAYL-----GM--------TGRRISTPSdALFVGLGTHYVPSGKL 233
Cdd:PRK09245 150 G--GAWLlpriiGMaraaemafTGDAIDAAT-ALEWGLVSRVVPADQL 194
PRK07260 PRK07260
enoyl-CoA hydratase; Provisional
 54-241 2.00e-06

enoyl-CoA hydratase; Provisional


Pssm-ID: 180910 [Multi-domain]  Cd Length: 255  Bit Score: 48.97  E-value: 2.00e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679  54 NGVALITLDRPKALNAMNLEMDLKYKSLLDEWEYDPGVKCVVVEgSTSRAFCAGGDVKQItSKNQLSDMIEVFTAEYSLI 133
Cdd:PRK07260  10 DDLATLTLNRPEVSNGFNIPMCQEILEALRLAEEDPSVRFLLIN-ANGKVFSVGGDLVEM-KRAVDEDDVQSLVKIAELV 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679 134 CKIA----GYRKPYISLMDGITMGFGLGLSGHGRYRVITERTVLAMPENGIGLFPDVGFSYIAAHSPGEgSVGAYLGMTG 209
Cdd:PRK07260  88 NEISfaikQLPKPVIMCVDGAVAGAAANMAVAADFCIASTKTKFIQAFVGVGLAPDAGGLFLLTRAIGL-NRATHLAMTG 166

                        170       180       190
                 ....*....|....*....|....*....|..
gi 145332679 210 RRISTpSDALFVGLGTHYVPSGKLGSLREAIL 241
Cdd:PRK07260 167 EALTA-EKALEYGFVYRVAESEKLEKTCEQLL 197
PLN02664 PLN02664
enoyl-CoA hydratase/delta3,5-delta2,4-dienoyl-CoA isomerase
 54-223 2.82e-06

enoyl-CoA hydratase/delta3,5-delta2,4-dienoyl-CoA isomerase


Pssm-ID: 178269 [Multi-domain]  Cd Length: 275  Bit Score: 48.36  E-value: 2.82e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679  54 NGVALITLDRPKALNAMNLEMDLKYKSLLDEWEYDPGVKCVVVEGsTSRAFCAGGDVK---QITSKNQLSD--------- 121
Cdd:PLN02664  16 SSVFHLNLNRPSQRNALSLDFFTEFPKALSSLDQNPNVSVIILSG-AGDHFCSGIDLKtlnSISEQSSSGDrgrsgerlr 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679 122 -----MIEVFTAeyslickIAGYRKPYISLMDGITMGFGLGLSGHGRYRVITERTVLAMPENGIGLFPDVGFSYIAAHSP 196
Cdd:PLN02664  95 rkikfLQDAITA-------IEQCRKPVIAAIHGACIGGGVDIVTACDIRYCSEDAFFSVKEVDLAITADLGTLQRLPSIV 167

                        170       180
                 ....*....|....*....|....*..
gi 145332679 197 GEGSvGAYLGMTGRRISTpSDALFVGL 223
Cdd:PLN02664 168 GYGN-AMELALTGRRFSG-SEAKELGL 192
menB TIGR01929
naphthoate synthase (dihydroxynaphthoic acid synthetase); This model represents an enzyme, ...
 54-111 3.48e-06

naphthoate synthase (dihydroxynaphthoic acid synthetase); This model represents an enzyme, naphthoate synthase (dihydroxynaphthoic acid synthetase), which is involved in the fifth step of the menaquinone biosynthesis pathway. Together with o-succinylbenzoate-CoA ligase (menE: TIGR01923), this enzyme takes 2-succinylbenzoate and converts it into 1,4-di-hydroxy-2-naphthoate. Included above the trusted cutoff are two enzymes from Arabadopsis thaliana and one from Staphylococcus aureus which are identified as putative enoyl-CoA hydratase/isomerases. These enzymes group with the naphthoate synthases when building a tree and when doing BLAST searches. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 200143 [Multi-domain]  Cd Length: 259  Bit Score: 48.31  E-value: 3.48e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 145332679   54 NGVALITLDRPKALNAMNLEMDLKYKSLLDEWEYDPGVKCVVVEGSTSRAFCAGGDVK 111
Cdd:TIGR01929  11 DGIAKITINRPQVRNAFRPLTVKEIIQALDDAREDPDIGVVILTGAGDKAFCSGGDQK 68
PRK05674 PRK05674
gamma-carboxygeranoyl-CoA hydratase; Validated
 53-250 4.19e-06

gamma-carboxygeranoyl-CoA hydratase; Validated


Pssm-ID: 168168  Cd Length: 265  Bit Score: 47.88  E-value: 4.19e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679  53 PNGVALITLDRPKALNAMNLEMDLKYKSLLDEWEYDPGVKCVVVEGStSRAFCAGGDV------KQITSKNQLSDMIEVF 126
Cdd:PRK05674  13 PRGFATLWLSRADKNNAFNAQMIRELILALDQVQSDASLRFLLLRGR-GRHFSAGADLawmqqsADLDYNTNLDDARELA 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679 127 TAEYSLickiAGYRKPYISLMDGITMGFGLGLSGHGRYRVITERTVLAMPENGIGLFPDVgFSYIAAHSPGEGSVGAYlG 206
Cdd:PRK05674  92 ELMYNL----YRLKIPTLAVVQGAAFGGALGLISCCDMAIGADDAQFCLSEVRIGLAPAV-ISPFVVKAIGERAARRY-A 165

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 145332679 207 MTGRRISTpSDALFVGLGTHYVPSGKLGSLREAILSADLSKDPQ 250
Cdd:PRK05674 166 LTAERFDG-RRARELGLLAESYPAAELEAQVEAWIANLLLNSPQ 208
PRK12478 PRK12478
crotonase/enoyl-CoA hydratase family protein;
56-109 5.49e-06

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 183548  Cd Length: 298  Bit Score: 47.64  E-value: 5.49e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 145332679  56 VALITLDRPKALNAMNLEMDLKYKSLLDEWEYDPGVKCVVVEGStSRAFCAGGD 109
Cdd:PRK12478  15 VATITLNRPEQLNTIVPPMPDEIEAAIGLAERDQDIKVIVLRGA-GRAFSGGYD 67
PRK07938 PRK07938
enoyl-CoA hydratase family protein;
54-177 9.46e-06

enoyl-CoA hydratase family protein;


Pssm-ID: 181174  Cd Length: 249  Bit Score: 46.89  E-value: 9.46e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679  54 NGVALITLDRPKaLNAMNLEMDLKYKSLLDEWEYDPGVKCVVV--EGstsRAFCAGGDVKQITSKNQLSDMIEV------ 125
Cdd:PRK07938  10 PGIAEVTVDYPP-VNALPSAGWFALADAITAAGADPDTRVVVLraEG---RGFNAGVDIKELQATPGFTALIDAnrgcfa 85

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 145332679 126 -FTAEYSliCkiagyRKPYISLMDGITMGFGLGLSGHGRYRVITERTVLAMPE 177
Cdd:PRK07938  86 aFRAVYE--C-----AVPVIAAVHGFCLGGGIGLVGNADVIVASDDATFGLPE 131
PLN03214 PLN03214
probable enoyl-CoA hydratase/isomerase; Provisional
 40-233 1.81e-05

probable enoyl-CoA hydratase/isomerase; Provisional


Pssm-ID: 215635  Cd Length: 278  Bit Score: 46.03  E-value: 1.81e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679  40 ASGSDEFVKGNVYPNGVALITLDRpKALNAMNLEMDLKYKSLLDEWEYDPGVKCVVVEGSTSR-AFCAGGDVKQITS-KN 117
Cdd:PLN03214   6 PPGATPGVRVDRRPGGIAVVWLAK-EPVNSMTLAMWRSLDDALTALENDPTVRGVVFASGLRRdVFTAGNDIAELYApKT 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679 118 QLSDMIEVFTAEYSLICKIAGYRKPYISLMDGITMGFGLGLSGHGRYRVITERTVLAMPENGIGL----FPDVGFSYIA- 192
Cdd:PLN03214  85 SAARYAEFWLTQTTFLVRLLRSRLATVCAIRGACPAGGCAVSLCCDYRLQTTEGTMGLNEVALGIpvpkFWARLFMGRVi 164

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 145332679 193 AHSPGEGSVgaylgMTGRRIStPSDALFVGLGTHYVPSGKL 233
Cdd:PLN03214 165 DRKVAESLL-----LRGRLVR-PAEAKQLGLIDEVVPAAAL 199
PRK07112 PRK07112
enoyl-CoA hydratase/isomerase;
55-184 1.93e-04

enoyl-CoA hydratase/isomerase;


Pssm-ID: 235938  Cd Length: 255  Bit Score: 42.75  E-value: 1.93e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332679  55 GVALITLDRPKALNAMNLEMDLKYKSLLDEWEYDpgVKCVVVEGsTSRAFCAGGDVKQITSKNQLSdMIEVFTAE--YSL 132
Cdd:PRK07112  13 DVCFLQLHRPEAQNTINDRLIAECMDVLDRCEHA--ATIVVLEG-LPEVFCFGADFSAIAEKPDAG-RADLIDAEplYDL 88

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 145332679 133 ICKIAgyRKPYISL--MDGITMGFGLGLSGHGRYRVITERTVLAMPENGIGLFP 184
Cdd:PRK07112  89 WHRLA--TGPYVTIahVRGKVNAGGIGFVAASDIVIADETAPFSLSELLFGLIP 140
PRK08290 PRK08290
enoyl-CoA hydratase; Provisional
 54-111 3.70e-04

enoyl-CoA hydratase; Provisional


Pssm-ID: 236220 [Multi-domain]  Cd Length: 288  Bit Score: 42.26  E-value: 3.70e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 145332679  54 NGVALITLDRPKALNAMNLEMDLKYKSLLDEWEYDPGVKCVVVEGStSRAFCAGGDVK 111
Cdd:PRK08290  12 GRIARITLNRPEARNAQNRQMLYELDAAFRRAEADDAVRVIVLAGA-GKHFSAGHDLG 68
PLN02921 PLN02921
naphthoate synthase
 53-109 1.30e-03

naphthoate synthase


Pssm-ID: 178509 [Multi-domain]  Cd Length: 327  Bit Score: 40.54  E-value: 1.30e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 145332679  53 PNGVALITLDRPKALNAMNLEMDLKYKSLLDEWEYDPGVKCVVVEGSTSRAFCAGGD 109
Cdd:PLN02921  74 GEGIAKITINRPERRNAFRPRTVKELQRAFNDARDDSSVGVIILTGKGTKAFCSGGD 130
PRK07396 PRK07396
dihydroxynaphthoic acid synthetase; Validated
 54-111 1.87e-03

dihydroxynaphthoic acid synthetase; Validated


Pssm-ID: 180958 [Multi-domain]  Cd Length: 273  Bit Score: 39.88  E-value: 1.87e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 145332679  54 NGVALITLDRPKALNA----MNLEMdlkYKSLLDEwEYDPGVKCVVVEGSTSRAFCAGGDVK 111
Cdd:PRK07396  21 DGIAKITINRPEVRNAfrpkTVKEM---IDAFADA-RDDDNIGVIILTGAGDKAFCSGGDQK 78
PRK07854 PRK07854
enoyl-CoA hydratase; Provisional
 56-109 2.64e-03

enoyl-CoA hydratase; Provisional


Pssm-ID: 236115 [Multi-domain]  Cd Length: 243  Bit Score: 39.24  E-value: 2.64e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 145332679  56 VALITLDRPKALNAMNLEMDLKYKSLLDEWEyDPGVKCVVVEGSTSrAFCAGGD 109
Cdd:PRK07854  10 VLTIELQRPERRNALNAELCEELREAVRKAV-DESARAIVLTGQGT-VFCAGAD 61
MenB COG0447
1,4-Dihydroxy-2-naphthoyl-CoA synthase [Coenzyme transport and metabolism]; 1, ...
 54-109 5.21e-03

1,4-Dihydroxy-2-naphthoyl-CoA synthase [Coenzyme transport and metabolism]; 1,4-Dihydroxy-2-naphthoyl-CoA synthase is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440216  Cd Length: 281  Bit Score: 38.65  E-value: 5.21e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 145332679  54 NGVALITLDRPKALNA----MNLEMdlkYKSLLDEWEyDPGVKCVVVEG-----STSRAFCAGGD 109
Cdd:COG0447   26 EGIARIAINRPEVRNAfrpeTVDEL---YDALDHARE-DPDVGVVLLTGngpskDGGWAFCSGGD 86
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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