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Conserved domains on  [gi|145331417|ref|NP_001078067|]
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plasma membrane intrinsic protein 1B [Arabidopsis thaliana]

Protein Classification

MIP/aquaporin family protein( domain architecture ID 11088534)

MIP (Major Intrinsic Protein)/aquaporin family protein similar to aquaporin that permits osmotically driven movement of water in both directions, and glycerol uptake facilitator protein that mediates glycerol diffusion across the cytoplasmic membrane via a pore-type mechanism

CATH:  1.20.1080.10
Gene Ontology:  GO:0055085|GO:0015267
PubMed:  11473620|8849412|11964478
SCOP:  3000508
TCDB:  1.A.8

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 44-261 3.51e-90

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


:

Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 267.65  E-value: 3.51e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145331417   44 ELASWSFWRAGIAEFIATFLFLYITVLTVMGVKRSPNMCASVGIQGIAWAFGGMIFALVYCTAGISGGHINPAVTFGLFL 123
Cdd:pfam00230   1 ELRSVSFLRAVIAEFLATLLFVFFGVGSALGVKKLVSSLAVSGLLAVALAFGLALATLVYCAGHISGAHLNPAVTLALLV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145331417  124 ARKLSLTRAVYYIVMQCLGAICGAGVVKGFQPKqYQALGGGANTIAHGYTKGSGLGAEIIGTFVLVYTVFSATDAKRNAR 203
Cdd:pfam00230  81 GRRFSLLRAIFYIVAQLLGAIAGAALLYGVTVG-LQRAGLFANTLAPGVNAGQAFVVEIILTFQLVYCVFATTDDRRNGS 159

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 145331417  204 DSHVpilAPLPIGFAVFLVHLATIPITGTGINPARSLGAAIIFNKdnaWDDHVMGLLG 261
Cdd:pfam00230 160 LGTV---APLAIGFAVFLNHLAGGPYTGASMNPARSFGPAVVLWK---WDDHWVYWVG 211
 
Name Accession Description Interval E-value
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 44-261 3.51e-90

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 267.65  E-value: 3.51e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145331417   44 ELASWSFWRAGIAEFIATFLFLYITVLTVMGVKRSPNMCASVGIQGIAWAFGGMIFALVYCTAGISGGHINPAVTFGLFL 123
Cdd:pfam00230   1 ELRSVSFLRAVIAEFLATLLFVFFGVGSALGVKKLVSSLAVSGLLAVALAFGLALATLVYCAGHISGAHLNPAVTLALLV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145331417  124 ARKLSLTRAVYYIVMQCLGAICGAGVVKGFQPKqYQALGGGANTIAHGYTKGSGLGAEIIGTFVLVYTVFSATDAKRNAR 203
Cdd:pfam00230  81 GRRFSLLRAIFYIVAQLLGAIAGAALLYGVTVG-LQRAGLFANTLAPGVNAGQAFVVEIILTFQLVYCVFATTDDRRNGS 159

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 145331417  204 DSHVpilAPLPIGFAVFLVHLATIPITGTGINPARSLGAAIIFNKdnaWDDHVMGLLG 261
Cdd:pfam00230 160 LGTV---APLAIGFAVFLNHLAGGPYTGASMNPARSFGPAVVLWK---WDDHWVYWVG 211
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 52-255 4.71e-71

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


Pssm-ID: 238204  Cd Length: 228  Bit Score: 219.05  E-value: 4.71e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145331417  52 RAGIAEFIATFLFLYITVLTVMGVKRSPNmcASVGIQGIAWAFGGMIFALVYCTAGISGGHINPAVTFGLFLARKLSLTR 131
Cdd:cd00333    1 RKYLAEFLGTFLLVFFGCGSVLAVKLAGG--ASGGLLGIALAWGFAIFVLVYAVGHISGGHINPAVTLALAVGGRFPLIR 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145331417 132 AVYYIVMQCLGAICGAGVVKGFQPKQYQALGGGANTIAH--------GYTKGSGLGAEIIGTFVLVYTVFSATDAKRNAr 203
Cdd:cd00333   79 VIPYIIAQLLGAILGAALLYGLYYGLYLEFLGANNIVAGifgtypspGVSNGNAFFVEFIGTFILVLVVFATTDDPNGP- 157

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 145331417 204 dsHVPILAPLPIGFAVFLVHLATIPITGTGINPARSLGAAIIFNKDNAWDDH 255
Cdd:cd00333  158 --PPGGLAPLAIGLLVAAIGLAGGPITGASMNPARSLGPALFTGLARHWHYF 207
MIP TIGR00861
MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is ...
 56-255 4.91e-64

MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is large and diverse, possessing over 100 members that all form transmembrane channels. These channel proteins function in water, smallcarbohydrate (e.g., glycerol), urea, NH3, CO2 and possibly ion transport by an energy independent mechanism. They are found ubiquitously in bacteria, archaeaand eukaryotes. The MIP family contains two major groups of channels: aquaporins and glycerol facilitators.The known aquaporins cluster loosely together as do the known glycerol facilitators. MIP family proteins are believed to form aqueous pores that selectively allow passive transport of their solute(s) across the membrane with minimal apparent recognition. Aquaporins selectively transport water (but not glycerol) while glycerol facilitators selectively transport glycerol but not water. Some aquaporins can transport NH3 and CO2. Glycerol facilitators function as solute nonspecific channels, and may transport glycerol, dihydroxyacetone, propanediol, urea and other small neutral molecules in physiologically importantprocesses. Some members of the family, including the yeast FPS protein (TC #1.A.8.5.1) and tobacco NtTIPA may transport both water and small solutes. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273306 [Multi-domain]  Cd Length: 216  Bit Score: 200.60  E-value: 4.91e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145331417   56 AEFIATFLFLYITVLTVMGVKRsPNMCASVGIQ---GIAWAFGGMIFALVYCTAGISGGHINPAVTFGLFLARKLSLTRA 132
Cdd:TIGR00861   1 AEFLGTFLLVFFGVGSALGVNV-AGAYGAVGGGqflGVALAFGLAVATLVYCVGGISGAHLNPAVTIALLLGRRFPLKRV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145331417  133 VYYIVMQCLGAICGAGVVKGFQPKQYQALGGGANTIAHGYTKGSGLGAEIIGTFVLVYTVFSATDaKRNARDSHvpILAP 212
Cdd:TIGR00861  80 PVYIVAQLIGAILGAALLYGLTSGLFPGNLAVNGSASAGVSSGQAFFVEFIGTAILVLVIFATTD-DRNRVPRG--GFAP 156

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 145331417  213 LPIGFAVFLVHLATIPITGTGINPARSLGAAIIFNKDNaWDDH 255
Cdd:TIGR00861 157 LAIGLLVFLIHLSMGPYTGTGMNPARSLGPALFAGLAG-WGNH 198
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 49-252 1.54e-51

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 169.15  E-value: 1.54e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145331417  49 SFWRAGIAEFIATFLFLYITVLTVMGVKRSPnmcASVGIQGIAWAFGGMIFALVYCTAGISGGHINPAVTFGLFLARKLS 128
Cdd:COG0580    1 SLMKRLLAEFLGTFILVLLGCGVVAVLAGTK---GGIGWLGIALAWGLAVLAGVYAFGHISGAHLNPAVTLALAVAGRFP 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145331417 129 LTRAVYYIVMQCLGAICGAGVVKGFQPKQYQA-------LGGGANTIAHGYTKGSGLGAEIIGTFVLVYTVFSATDAKRN 201
Cdd:COG0580   78 WKDVLPYIIAQLLGAFLGAALVYLIYGGHFDAtedggakLGVFATSPAIGYSLGAAFLTEIIGTFVLVFVILGITDKRAA 157

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 145331417 202 ARDshvpiLAPLPIGFAVFLVHLATIPITGTGINPARSLGAAI---IFNKDNAW 252
Cdd:COG0580  158 PGG-----LAPLAIGLLVAAIGLSLGPLTGYAINPARDLGPRLfhaLGKGGSDW 206
PRK05420 PRK05420
aquaporin Z; Provisional
 55-244 1.13e-27

aquaporin Z; Provisional


Pssm-ID: 235453 [Multi-domain]  Cd Length: 231  Bit Score: 106.98  E-value: 1.13e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145331417  55 IAEFIATFlflyitVLTVMGvkrspnmCAS-----------VGIQGIAWAFGGMIFALVYCTAGISGGHINPAVTFGLFL 123
Cdd:PRK05420   6 AAEFFGTF------WLVFGG-------CGSavlaaafpelgIGFLGVALAFGLTVLTMAYAVGHISGGHFNPAVSVGLWA 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145331417 124 ARKLSLTRAVYYIVMQCLGAICGAGVV--------------KGFQPKQYQALGGGantiahGYTKGSGLGAEIIGTFVLV 189
Cdd:PRK05420  73 GGRFPAKELVPYIIAQVVGGIAAAAVLyliasgkagfdlagSGFASNGYGEHSPG------GYSLLAALVCEVVLTAFFL 146

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 145331417 190 YTVFSATDAKRNARdshvpiLAPLPIGFAVFLVHLATIPITGTGINPARSLGAAI 244
Cdd:PRK05420 147 LVILGATDKRAPAG------FAPIAIGLALTLIHLISIPVTNTSVNPARSTGVAL 195
 
Name Accession Description Interval E-value
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 44-261 3.51e-90

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 267.65  E-value: 3.51e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145331417   44 ELASWSFWRAGIAEFIATFLFLYITVLTVMGVKRSPNMCASVGIQGIAWAFGGMIFALVYCTAGISGGHINPAVTFGLFL 123
Cdd:pfam00230   1 ELRSVSFLRAVIAEFLATLLFVFFGVGSALGVKKLVSSLAVSGLLAVALAFGLALATLVYCAGHISGAHLNPAVTLALLV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145331417  124 ARKLSLTRAVYYIVMQCLGAICGAGVVKGFQPKqYQALGGGANTIAHGYTKGSGLGAEIIGTFVLVYTVFSATDAKRNAR 203
Cdd:pfam00230  81 GRRFSLLRAIFYIVAQLLGAIAGAALLYGVTVG-LQRAGLFANTLAPGVNAGQAFVVEIILTFQLVYCVFATTDDRRNGS 159

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 145331417  204 DSHVpilAPLPIGFAVFLVHLATIPITGTGINPARSLGAAIIFNKdnaWDDHVMGLLG 261
Cdd:pfam00230 160 LGTV---APLAIGFAVFLNHLAGGPYTGASMNPARSFGPAVVLWK---WDDHWVYWVG 211
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 52-255 4.71e-71

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


Pssm-ID: 238204  Cd Length: 228  Bit Score: 219.05  E-value: 4.71e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145331417  52 RAGIAEFIATFLFLYITVLTVMGVKRSPNmcASVGIQGIAWAFGGMIFALVYCTAGISGGHINPAVTFGLFLARKLSLTR 131
Cdd:cd00333    1 RKYLAEFLGTFLLVFFGCGSVLAVKLAGG--ASGGLLGIALAWGFAIFVLVYAVGHISGGHINPAVTLALAVGGRFPLIR 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145331417 132 AVYYIVMQCLGAICGAGVVKGFQPKQYQALGGGANTIAH--------GYTKGSGLGAEIIGTFVLVYTVFSATDAKRNAr 203
Cdd:cd00333   79 VIPYIIAQLLGAILGAALLYGLYYGLYLEFLGANNIVAGifgtypspGVSNGNAFFVEFIGTFILVLVVFATTDDPNGP- 157

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 145331417 204 dsHVPILAPLPIGFAVFLVHLATIPITGTGINPARSLGAAIIFNKDNAWDDH 255
Cdd:cd00333  158 --PPGGLAPLAIGLLVAAIGLAGGPITGASMNPARSLGPALFTGLARHWHYF 207
MIP TIGR00861
MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is ...
 56-255 4.91e-64

MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is large and diverse, possessing over 100 members that all form transmembrane channels. These channel proteins function in water, smallcarbohydrate (e.g., glycerol), urea, NH3, CO2 and possibly ion transport by an energy independent mechanism. They are found ubiquitously in bacteria, archaeaand eukaryotes. The MIP family contains two major groups of channels: aquaporins and glycerol facilitators.The known aquaporins cluster loosely together as do the known glycerol facilitators. MIP family proteins are believed to form aqueous pores that selectively allow passive transport of their solute(s) across the membrane with minimal apparent recognition. Aquaporins selectively transport water (but not glycerol) while glycerol facilitators selectively transport glycerol but not water. Some aquaporins can transport NH3 and CO2. Glycerol facilitators function as solute nonspecific channels, and may transport glycerol, dihydroxyacetone, propanediol, urea and other small neutral molecules in physiologically importantprocesses. Some members of the family, including the yeast FPS protein (TC #1.A.8.5.1) and tobacco NtTIPA may transport both water and small solutes. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273306 [Multi-domain]  Cd Length: 216  Bit Score: 200.60  E-value: 4.91e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145331417   56 AEFIATFLFLYITVLTVMGVKRsPNMCASVGIQ---GIAWAFGGMIFALVYCTAGISGGHINPAVTFGLFLARKLSLTRA 132
Cdd:TIGR00861   1 AEFLGTFLLVFFGVGSALGVNV-AGAYGAVGGGqflGVALAFGLAVATLVYCVGGISGAHLNPAVTIALLLGRRFPLKRV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145331417  133 VYYIVMQCLGAICGAGVVKGFQPKQYQALGGGANTIAHGYTKGSGLGAEIIGTFVLVYTVFSATDaKRNARDSHvpILAP 212
Cdd:TIGR00861  80 PVYIVAQLIGAILGAALLYGLTSGLFPGNLAVNGSASAGVSSGQAFFVEFIGTAILVLVIFATTD-DRNRVPRG--GFAP 156

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 145331417  213 LPIGFAVFLVHLATIPITGTGINPARSLGAAIIFNKDNaWDDH 255
Cdd:TIGR00861 157 LAIGLLVFLIHLSMGPYTGTGMNPARSLGPALFAGLAG-WGNH 198
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 49-252 1.54e-51

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 169.15  E-value: 1.54e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145331417  49 SFWRAGIAEFIATFLFLYITVLTVMGVKRSPnmcASVGIQGIAWAFGGMIFALVYCTAGISGGHINPAVTFGLFLARKLS 128
Cdd:COG0580    1 SLMKRLLAEFLGTFILVLLGCGVVAVLAGTK---GGIGWLGIALAWGLAVLAGVYAFGHISGAHLNPAVTLALAVAGRFP 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145331417 129 LTRAVYYIVMQCLGAICGAGVVKGFQPKQYQA-------LGGGANTIAHGYTKGSGLGAEIIGTFVLVYTVFSATDAKRN 201
Cdd:COG0580   78 WKDVLPYIIAQLLGAFLGAALVYLIYGGHFDAtedggakLGVFATSPAIGYSLGAAFLTEIIGTFVLVFVILGITDKRAA 157

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 145331417 202 ARDshvpiLAPLPIGFAVFLVHLATIPITGTGINPARSLGAAI---IFNKDNAW 252
Cdd:COG0580  158 PGG-----LAPLAIGLLVAAIGLSLGPLTGYAINPARDLGPRLfhaLGKGGSDW 206
PRK05420 PRK05420
aquaporin Z; Provisional
 55-244 1.13e-27

aquaporin Z; Provisional


Pssm-ID: 235453 [Multi-domain]  Cd Length: 231  Bit Score: 106.98  E-value: 1.13e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145331417  55 IAEFIATFlflyitVLTVMGvkrspnmCAS-----------VGIQGIAWAFGGMIFALVYCTAGISGGHINPAVTFGLFL 123
Cdd:PRK05420   6 AAEFFGTF------WLVFGG-------CGSavlaaafpelgIGFLGVALAFGLTVLTMAYAVGHISGGHFNPAVSVGLWA 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145331417 124 ARKLSLTRAVYYIVMQCLGAICGAGVV--------------KGFQPKQYQALGGGantiahGYTKGSGLGAEIIGTFVLV 189
Cdd:PRK05420  73 GGRFPAKELVPYIIAQVVGGIAAAAVLyliasgkagfdlagSGFASNGYGEHSPG------GYSLLAALVCEVVLTAFFL 146

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 145331417 190 YTVFSATDAKRNARdshvpiLAPLPIGFAVFLVHLATIPITGTGINPARSLGAAI 244
Cdd:PRK05420 147 LVILGATDKRAPAG------FAPIAIGLALTLIHLISIPVTNTSVNPARSTGVAL 195
PLN00166 PLN00166
aquaporin TIP2; Provisional
 43-245 2.12e-25

aquaporin TIP2; Provisional


Pssm-ID: 165733  Cd Length: 250  Bit Score: 101.55  E-value: 2.12e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145331417  43 GELASWSFWRAGIAEFIATFLFLYITVLTVMGVKRSPNMCA--SVGIQGIAWAFGGMIFALVYCTAGISGGHINPAVTFG 120
Cdd:PLN00166  10 GDSFSVASLKAYLSEFIATLLFVFAGVGSAIAFAKLTSDAAldPAGLVAVAVAHAFALFVGVSIAANISGGHLNPAVTLG 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145331417 121 LFLARKLSLTRAVYYIVMQCLGAICGAGVVKgfqpkqyqALGGGANTIAHGYTKG----SGLGAEIIGTFVLVYTVF-SA 195
Cdd:PLN00166  90 LAIGGNITIITGFFYWIAQCLGSIVACLLLV--------FVTNGESVPTHGVAAGlgaiEGVVMEIVVTFALVYTVYaTA 161

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 145331417 196 TDAKRNArdshVPILAPLPIGFAVFLVHLATIPITGTGINPARSLGAAII 245
Cdd:PLN00166 162 ADPKKGS----LGTIAPIAIGFIVGANILAAGPFSGGSMNPARSFGPAVV 207
PLN00167 PLN00167
aquaporin TIP5; Provisional
 52-248 1.72e-23

aquaporin TIP5; Provisional


Pssm-ID: 215085  Cd Length: 256  Bit Score: 96.51  E-value: 1.72e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145331417  52 RAGIAEFIATFLFLYITVLTVMGVKR-SPNMCA---SVGIQGIAWAFGgmIFALVYCTAGISGGHINPAVTFGLFLARKL 127
Cdd:PLN00167  23 RSYLAEFISTFFFVFAAVGSAMSSRKlMPDAASdpsSLLIVAIANAFA--LSSAVYIAANISGGHVNPAVTFGMAVGGHI 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145331417 128 SLTRAVYYIVMQCLGAICGAGVVKGFQPKQYQALgggaNTIAHGYTkgsGLGAEIIG---TFVLVYTVFSATDAKRNARD 204
Cdd:PLN00167 101 SVPTAMFYWISQMLASVMACLFLKVTTVGQHVPT----YKIAEEMT---GFGASVLEgvlTFGLVYTVYAAGDPRRGLLG 173

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 145331417 205 ShvpiLAPLPIGFAVFLVHLATIPITGTGINPARSLGAAIIFNK 248
Cdd:PLN00167 174 A----IGPLAIGLVAGANVLAAGPFSGGSMNPACAFGSAVVAGS 213
PLN00027 PLN00027
aquaporin TIP; Provisional
 42-266 2.50e-23

aquaporin TIP; Provisional


Pssm-ID: 177664  Cd Length: 252  Bit Score: 96.01  E-value: 2.50e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145331417  42 PGELASWSFWRAGIAEFIATFLFLYITVLTVMGVKRSPNMCASV--GIQGIAWAFGGMIFALVYCTAGISGGHINPAVTF 119
Cdd:PLN00027  11 PGEASHPDALKAALAEFISTLIFVFAGEGSGMAFNKLTDNGSTTpaGLVAAALAHAFALFVAVSVGANISGGHVNPAVTF 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145331417 120 GLFLARKLSLTRAVYYIVMQCLGAICGAGVVKgfqpkqyqALGGGANTIAHGYTKGSG----LGAEIIGTFVLVYTVF-S 194
Cdd:PLN00027  91 GAFIGGNITLLRGILYWIAQLLGSVVACLLLK--------FSTGGLETSAFSLSSGVGvwnaFVFEIVMTFGLVYTVYaT 162

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 145331417 195 ATDAKRnardSHVPILAPLPIGFAVFLVHLATIPITGTGINPARSLGAAIIfnkdnAWDdhvmgllgWTIHW 266
Cdd:PLN00027 163 AVDPKK----GDLGIIAPIAIGFIVGANILAGGAFDGASMNPAVSFGPAVV-----SWT--------WTNHW 217
PLN00184 PLN00184
aquaporin NIP1; Provisional
 36-247 9.78e-17

aquaporin NIP1; Provisional


Pssm-ID: 177778  Cd Length: 296  Bit Score: 78.52  E-value: 9.78e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145331417  36 PAPLFEPGELASWS--FWRAGIAEFIATFLFLYITVLTVMGVKRSPNmcaSVGIQGIAWAFGGMIFALVYCTAGISGGHI 113
Cdd:PLN00184  37 PKPLKKQDSLLSVSvpFLQKLIAEVLGTYFLVFTGCASVVVNMQNDN---VVTLPGIAIVWGLTIMVLIYSLGHISGAHI 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145331417 114 NPAVTFGLFLARKLSLTRAVYYIVMQCLGAICGAGVVKGFQPKQYQALGGGANTIAHGYTKGSGLGA---EIIGTFVLVY 190
Cdd:PLN00184 114 NPAVTIAFASCGRFPLKQVPAYVISQVIGSTLAAATLRLLFGLDHDVCSGKHDVFIGSSPVGSDLQAfvmEFIVTFYLMF 193

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 145331417 191 TVFS-ATDAKRnardshVPILAPLPIGFAVFLVHLATIPITGTGINPARSLGAAIIFN 247
Cdd:PLN00184 194 IISGvATDNRA------IGELAGLAIGSTVLLNVLIAAPVSSASMNPGRSLGPAMVYG 245
PTZ00016 PTZ00016
aquaglyceroporin; Provisional
 32-244 3.44e-16

aquaglyceroporin; Provisional


Pssm-ID: 240230 [Multi-domain]  Cd Length: 294  Bit Score: 77.09  E-value: 3.44e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145331417  32 KEPPPAPLF-EPGELASWsfWRAGIAEFIATFLFLYI---TVLTVMGVKRSPN-MCASVGiqgiaWAFGgmIFALVYCTA 106
Cdd:PTZ00016  32 KRPPGGQNFwAPREYRPN--VREYVAEFLGTFVLLFFgegVVATTHTVGNNGDyLAITIG-----WGLG--VTFGLLVSA 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145331417 107 GISGGHINPAVTFGLFLARKLSLTRAVYYIVMQCLGAICGA----GVVKGF---QPKQYQALGGGANTIAHGYTKGSGLG 179
Cdd:PTZ00016 103 GISGGHLNPAVTLGNAVFGKFPWKKLPGYFVAQLLGAFVGAacvyGLYYGFfkdHGIPELPWETMANGFAGVFATYPREG 182

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 145331417 180 A------EIIGTFVLVYTVFSATDAKRNARDSHVpilaPLPIGFAVFLVHLATIPITGTGINPARSLGAAI 244
Cdd:PTZ00016 183 NfyaifsELILTAILLLVILAITDPNNCPAFNYL----PVAVGLLVFVIGISFGGNTGYALNPARDLGPRL 249
PLN00183 PLN00183
putative aquaporin NIP7; Provisional
 52-253 4.99e-14

putative aquaporin NIP7; Provisional


Pssm-ID: 215092  Cd Length: 274  Bit Score: 70.66  E-value: 4.99e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145331417  52 RAGIAEFIATFLFLYitvlTVMGVKRSPN-MCASVGIQGIAWAFGGMIFALVYCTAGISGGHINPAVTFGLFLARKLSLT 130
Cdd:PLN00183  46 RMVLAEMVGTFILMF----CVCGIIASTQlSGGEVGLLEYAATAGLTVVVVVFSIGSISGAHVNPSVTIAFATFGHFPWS 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145331417 131 RAVYYIVMQCLGAICGAGVVKgfqpkqyQALGGGANTIAHGYTKG--SGLGAEIIGTFVLVYTVFSATDAKRNARDshvp 208
Cdd:PLN00183 122 KVPLYITAQTVGSVLATYVGV-------SVYGVKADLMTTKPAQGcsSAFWVEFIATFIVMFLAASLTSQPQSLGH---- 190

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 145331417 209 iLAPLPIGFAVFLVHLATIPITGTGINPARSLGAAIIfnkdnAWD 253
Cdd:PLN00183 191 -LSGFVIGIAIGLAVLITGPVSGGSMNPARSLGPAIV-----SWD 229
PLN00182 PLN00182
putative aquaporin NIP4; Provisional
 55-245 2.44e-13

putative aquaporin NIP4; Provisional


Pssm-ID: 165748  Cd Length: 283  Bit Score: 68.78  E-value: 2.44e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145331417  55 IAEFIATflflYITVLTVMGVKRSPNM-CASVGIQGIAWAFGGMIFALVYCTAGISGGHINPAVTFGLFLARKLSLTRAV 133
Cdd:PLN00182  46 IAEMIGT----YFIIFSGCGVVVVNVLyGGTITFPGICVTWGLIVMVMIYSTGHISGAHFNPAVTVTFAIFRRFPWYQVP 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145331417 134 YYIVMQCLGAICGAGVVKGFQPKQYQALGGGANTiahgYTKGSGLGAEIIGTFVLVYTVFSATDAKRNARDshvpiLAPL 213
Cdd:PLN00182 122 LYIGAQLTGSLLASLTLRLMFNVTPEAFFGTTPT----DSSGQALVAEIIISFLLMFVISGVATDSRAVGE-----LAGI 192

                        170       180       190
                 ....*....|....*....|....*....|..
gi 145331417 214 PIGFAVFLVHLATIPITGTGINPARSLGAAII 245
Cdd:PLN00182 193 AVGMTIILNVFVAGPISGASMNPARSLGPAIV 224
PLN00026 PLN00026
aquaporin NIP; Provisional
 56-244 1.85e-12

aquaporin NIP; Provisional


Pssm-ID: 177663 [Multi-domain]  Cd Length: 298  Bit Score: 66.42  E-value: 1.85e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145331417  56 AEFIATFLFLYITVLTVMGVKRSPNmcaSVGIQGIAWAFGGMIFALVYCTAGISGGHINPAVTFGLFLARKLSLTRAVYY 135
Cdd:PLN00026  76 AEFVGTFILIFAATAGPIVNQKYDG---AETLIGNAACAGLAVMIVILSTGHISGAHLNPSLTIAFAALRHFPWKHVPAY 152

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145331417 136 IVMQCLGAICGAGVVKG-FQPkqyqALGGGANTIAHGYtkGSGLGAEIIGTFVLVYTVFS-ATDAKRnardshVPILAPL 213
Cdd:PLN00026 153 IAAQVSASICASFALKGvFHP----FMSGGVTVPSVST--GQAFALEFIITFNLLFVVTAvATDTRA------VGELAGI 220

                        170       180       190
                 ....*....|....*....|....*....|.
gi 145331417 214 PIGFAVFLVHLATIPITGTGINPARSLGAAI 244
Cdd:PLN00026 221 AVGATVMLNILVAGPSTGGSMNPVRTLGPAV 251
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 49-153 2.61e-07

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 50.51  E-value: 2.61e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145331417  49 SFWRAGIAEFIATFLFlyitVLTVMGVKRSPNMCASVGiqgiAWAFGGMIFALVYCTAGISGGHINPAVTFG--LFLARK 126
Cdd:COG0580  129 SLGAAFLTEIIGTFVL----VFVILGITDKRAAPGGLA----PLAIGLLVAAIGLSLGPLTGYAINPARDLGprLFHALG 200

                         90       100       110
                 ....*....|....*....|....*....|
gi 145331417 127 LS---LTRAVYYIVMQCLGAICGAGVVKGF 153
Cdd:COG0580  201 KGgsdWGYLWVPIVAPILGAALAALLYRAL 230
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 49-147 1.20e-05

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


Pssm-ID: 238204  Cd Length: 228  Bit Score: 45.71  E-value: 1.20e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145331417  49 SFWRAGIAEFIATFLFlyitVLTVMGVKRSPNMCASVGIQgiAWAFGGMIFALVYCTAGISGGHINPAVTFG--LFLARK 126
Cdd:cd00333  128 SNGNAFFVEFIGTFIL----VLVVFATTDDPNGPPPGGLA--PLAIGLLVAAIGLAGGPITGASMNPARSLGpaLFTGLA 201

                         90       100
                 ....*....|....*....|.
gi 145331417 127 LSLTRAVYYIVMQCLGAICGA 147
Cdd:cd00333  202 RHWHYFWVYWVGPLIGAIAGA 222
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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