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Conserved domains on  [gi|145329951|ref|NP_001077961|]
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Ankyrin repeat family protein [Arabidopsis thaliana]

Protein Classification

ankyrin repeat domain-containing protein( domain architecture ID 11429852)

ankyrin repeat domain-containing protein; ANK proteins mediate specific protein-protein interactions without necessarily recognizing specific primary sequences which allows for one ankyrin repeat domain to recognize and bind to a variety of intracellular substrates and may be involved in a wide array of functions

Gene Ontology:  GO:0005515
PubMed:  17176038
SCOP:  4000366

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
60-152 1.13e-15

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 72.29  E-value: 1.13e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145329951  60 NARSALNAGLDTPQRDYEASGEGLREAIKNGDSAGAKKLLKEGVDANYRDRQGMSVLHLAVLFNQTDIALMLMDHGASLE 139
Cdd:COG0666   68 LVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVN 147

                         90
                 ....*....|...
gi 145329951 140 YKNAQGETPLDCA 152
Cdd:COG0666  148 AQDNDGNTPLHLA 160
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
60-152 1.13e-15

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 72.29  E-value: 1.13e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145329951  60 NARSALNAGLDTPQRDYEASGEGLREAIKNGDSAGAKKLLKEGVDANYRDRQGMSVLHLAVLFNQTDIALMLMDHGASLE 139
Cdd:COG0666   68 LVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVN 147

                         90
                 ....*....|...
gi 145329951 140 YKNAQGETPLDCA 152
Cdd:COG0666  148 AQDNDGNTPLHLA 160
Ank_2 pfam12796
Ankyrin repeats (3 copies);
83-152 1.16e-10

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 55.12  E-value: 1.16e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145329951   83 LREAIKNGDSAGAKKLLKEGVDANYRDRQGMSVLHLAVLFNQTDIALMLMDHGASLEykNAQGETPLDCA 152
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNL--KDNGRTALHYA 68
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 62-159 7.43e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 56.51  E-value: 7.43e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145329951  62 RSALNAGLDTPQRDYEaSGEGLREAIKNGDSAGAKKLLKEGVDANYRDRQGMSVLHLAVLFNQTDIALMLMDHGASLEYK 141
Cdd:PHA02874 108 KTILDCGIDVNIKDAE-LKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVK 186

                         90
                 ....*....|....*...
gi 145329951 142 NAQGETPLDCAPATLQYK 159
Cdd:PHA02874 187 DNNGESPLHNAAEYGDYA 204
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 83-152 5.50e-05

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 42.31  E-value: 5.50e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 145329951  83 LREAIKNGDSAGAKKLLK-EGVDANYRDRQGMSVLHLAVLFNQTDIALMLMDhgASLEYKNA-------QGETPLDCA 152
Cdd:cd22192   21 LLLAAKENDVQAIKKLLKcPSCDLFQRGALGETALHVAALYDNLEAAVVLME--AAPELVNEpmtsdlyQGETALHIA 96
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 111-140 1.42e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 34.49  E-value: 1.42e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 145329951   111 QGMSVLHLAVLFNQTDIALMLMDHGASLEY 140
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
60-152 1.13e-15

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 72.29  E-value: 1.13e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145329951  60 NARSALNAGLDTPQRDYEASGEGLREAIKNGDSAGAKKLLKEGVDANYRDRQGMSVLHLAVLFNQTDIALMLMDHGASLE 139
Cdd:COG0666   68 LVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVN 147

                         90
                 ....*....|...
gi 145329951 140 YKNAQGETPLDCA 152
Cdd:COG0666  148 AQDNDGNTPLHLA 160
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
83-152 1.18e-15

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 72.29  E-value: 1.18e-15
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145329951  83 LREAIKNGDSAGAKKLLKEGVDANYRDRQGMSVLHLAVLFNQTDIALMLMDHGASLEYKNAQGETPLDCA 152
Cdd:COG0666  157 LHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLA 226
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
61-152 1.46e-15

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 72.29  E-value: 1.46e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145329951  61 ARSALNAGLDTPQRDyEASGEGLREAIKNGDSAGAKKLLKEGVDANYRDRQGMSVLHLAVLFNQTDIALMLMDHGASLEY 140
Cdd:COG0666  103 VKLLLEAGADVNARD-KDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNA 181

                         90
                 ....*....|..
gi 145329951 141 KNAQGETPLDCA 152
Cdd:COG0666  182 RDNDGETPLHLA 193
Ank_2 pfam12796
Ankyrin repeats (3 copies);
83-152 1.16e-10

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 55.12  E-value: 1.16e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145329951   83 LREAIKNGDSAGAKKLLKEGVDANYRDRQGMSVLHLAVLFNQTDIALMLMDHGASLEykNAQGETPLDCA 152
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNL--KDNGRTALHYA 68
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 62-159 7.43e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 56.51  E-value: 7.43e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145329951  62 RSALNAGLDTPQRDYEaSGEGLREAIKNGDSAGAKKLLKEGVDANYRDRQGMSVLHLAVLFNQTDIALMLMDHGASLEYK 141
Cdd:PHA02874 108 KTILDCGIDVNIKDAE-LKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVK 186

                         90
                 ....*....|....*...
gi 145329951 142 NAQGETPLDCAPATLQYK 159
Cdd:PHA02874 187 DNNGESPLHNAAEYGDYA 204
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
60-152 2.17e-09

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 54.96  E-value: 2.17e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145329951  60 NARSALNAGLDTPQRDYEASGEGLREAIKNGDSAGAKKLLKEGVDANYRDRQGMSVLHLAVLFNQTDIALMLMDHGASLE 139
Cdd:COG0666   35 LLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVN 114

                         90
                 ....*....|...
gi 145329951 140 YKNAQGETPLDCA 152
Cdd:COG0666  115 ARDKDGETPLHLA 127
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
83-165 1.13e-08

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 52.65  E-value: 1.13e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145329951  83 LREAIKNGDSAGAKKLLKEGVDANYRDRQGMSVLHLAVLFNQTDIALMLMDHGASLEYKNAQGETPLDCAPATLQYKMRE 162
Cdd:COG0666  190 LHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVK 269


                 ...
gi 145329951 163 KMK 165
Cdd:COG0666  270 LLL 272
Ank_5 pfam13857
Ankyrin repeats (many copies);
98-152 2.76e-08

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 47.73  E-value: 2.76e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 145329951   98 LLKEG-VDANYRDRQGMSVLHLAVLFNQTDIALMLMDHGASLEYKNAQGETPLDCA 152
Cdd:pfam13857   1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 89-152 4.75e-08

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 51.44  E-value: 4.75e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 145329951  89 NGDSAGAKKLLKEGVDANYRDRQGMSVLHLAVLFNQTDIALMLMDHGASLEYKNAQGETPLDCA 152
Cdd:PTZ00322  92 SGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELA 155
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 75-142 1.56e-06

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 46.78  E-value: 1.56e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 145329951  75 DYEASGEGLREAIKNGDSAGAKKLLKEGVDANYRDRQGMSVLHLAVLFNQTDIALMLMDHGASLEYKN 142
Cdd:PLN03192 618 DPHAAGDLLCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADVDKAN 685
Ank_4 pfam13637
Ankyrin repeats (many copies);
83-131 2.61e-06

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 42.65  E-value: 2.61e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 145329951   83 LREAIKNGDSAGAKKLLKEGVDANYRDRQGMSVLHLAVLFNQTDIALML 131
Cdd:pfam13637   5 LHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLL 53
Ank_2 pfam12796
Ankyrin repeats (3 copies);
86-142 1.24e-05

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 41.64  E-value: 1.24e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 145329951   86 AIKNGDSAGAKKLLKEgVDANYRDrQGMSVLHLAVLFNQTDIALMLMDHGASLEYKN 142
Cdd:pfam12796  37 AAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVKLLLEKGADINVKD 91
Ank_4 pfam13637
Ankyrin repeats (many copies);
112-152 2.70e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 39.95  E-value: 2.70e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 145329951  112 GMSVLHLAVLFNQTDIALMLMDHGASLEYKNAQGETPLDCA 152
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFA 41
PHA03095 PHA03095
ankyrin-like protein; Provisional
 98-151 4.01e-05

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 42.70  E-value: 4.01e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 145329951  98 LLKEGVDANYRDRQGMSVLH--LAVLFNQTDIALMLMDHGASLEYKNAQGETPLDC 151
Cdd:PHA03095 103 LIKAGADVNAKDKVGRTPLHvyLSGFNINPKVIRLLLRKGADVNALDLYGMTPLAV 158
PHA03095 PHA03095
ankyrin-like protein; Provisional
 98-149 5.47e-05

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 42.32  E-value: 5.47e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 145329951  98 LLKEGVDANYRDRQGMSVLHLAVLFNQT-DIALMLMDHGASLEYKNAQGETPL 149
Cdd:PHA03095  69 LLEAGADVNAPERCGFTPLHLYLYNATTlDVIKLLIKAGADVNAKDKVGRTPL 121
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 98-149 5.48e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 42.34  E-value: 5.48e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 145329951  98 LLKEGVDANYRDRQGMSVLHLAVLFNQTDIALMLMDHGASLEYKNAQGETPL 149
Cdd:PHA03100 178 LLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPL 229
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 83-152 5.50e-05

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 42.31  E-value: 5.50e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 145329951  83 LREAIKNGDSAGAKKLLK-EGVDANYRDRQGMSVLHLAVLFNQTDIALMLMDhgASLEYKNA-------QGETPLDCA 152
Cdd:cd22192   21 LLLAAKENDVQAIKKLLKcPSCDLFQRGALGETALHVAALYDNLEAAVVLME--AAPELVNEpmtsdlyQGETALHIA 96
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 32-134 5.58e-05

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 42.19  E-value: 5.58e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145329951  32 PPATIAPVVLPQLKSEASAKSkGSTSSSNARSALNAGLDTPQRDYEASGEgLREAIKNGDSAGAKKLLKEGVDANYRDRQ 111
Cdd:PTZ00322  70 TEEVIDPVVAHMLTVELCQLA-ASGDAVGARILLTGGADPNCRDYDGRTP-LHIACANGHVQVVRVLLEFGADPTLLDKD 147

                         90       100
                 ....*....|....*....|...
gi 145329951 112 GMSVLHLAVLFNQTDIALMLMDH 134
Cdd:PTZ00322 148 GKTPLELAEENGFREVVQLLSRH 170
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 90-160 5.93e-05

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 42.16  E-value: 5.93e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 145329951  90 GDSAGAKKLLKEGVDANYRDRQGMSVLHLAVLFNQTDIALMLMDHGASLEYKNAQGETPLDCAPATLQYKM 160
Cdd:PLN03192 536 GNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKI 606
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 65-149 1.47e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 41.02  E-value: 1.47e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145329951  65 LNAGLDTPQRDYEASGEGLREAIKNGDSAGAKKLLKEGVDANYRDRQGMSVLHLAVLFNQTDIALMLMDHGASLEYKNAQ 144
Cdd:PHA02878 154 LSYGADINMKDRHKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKC 233


                 ....*
gi 145329951 145 GETPL 149
Cdd:PHA02878 234 GNTPL 238
PHA03095 PHA03095
ankyrin-like protein; Provisional
 97-149 1.14e-03

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 38.47  E-value: 1.14e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 145329951  97 KLLKEGVDANYRDRQGMSVLHLAVLFNQTDIALMLMDHGASLEYKNAQGETPL 149
Cdd:PHA03095 242 PLLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPL 294
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 111-140 1.42e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 34.49  E-value: 1.42e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 145329951   111 QGMSVLHLAVLFNQTDIALMLMDHGASLEY 140
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
PHA03095 PHA03095
ankyrin-like protein; Provisional
 96-151 1.49e-03

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 38.08  E-value: 1.49e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 145329951  96 KKLLKEGVDANYRDRQGMSVLHLAVLFNQ---TDIALMLMDHGASLEYKNAQGETPLDC 151
Cdd:PHA03095  31 RRLLAAGADVNFRGEYGKTPLHLYLHYSSekvKDIVRLLLEAGADVNAPERCGFTPLHL 89
Ank_5 pfam13857
Ankyrin repeats (many copies);
86-119 1.65e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 35.01  E-value: 1.65e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 145329951   86 AIKNGDSAGAKKLLKEGVDANYRDRQGMSVLHLA 119
Cdd:pfam13857  23 AAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 96-149 2.06e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 37.66  E-value: 2.06e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 145329951  96 KKLLKEGVDANYRDRQGMSVLHLAVLFNQTDIALMLMDHGASLEYKNAQGETPL 149
Cdd:PHA02875 119 KLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPL 172
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 64-151 3.13e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 36.89  E-value: 3.13e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145329951  64 ALNAGLDTPQRDYEASgegLREAIKNGDSAGAKKLLKEGVDANYRDRQGMSVLHLAVLFNQTDIALMLMDHGASLEYKNA 143
Cdd:PHA02875 123 ARGADPDIPNTDKFSP---LHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYFGK 199


                 ....*...
gi 145329951 144 QGETPLDC 151
Cdd:PHA02875 200 NGCVAALC 207
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 72-162 3.16e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 36.89  E-value: 3.16e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145329951  72 PQRDYEASGEGLREAIKNGDSAGAKKLLKEGVDAN---YRDrqGMSVLHLAVLFNQTDIALMLMDHGASLEYKNAQGETP 148
Cdd:PHA02875  61 PDVKYPDIESELHDAVEEGDVKAVEELLDLGKFADdvfYKD--GMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSP 138

                         90
                 ....*....|....
gi 145329951 149 LDCAPATLQYKMRE 162
Cdd:PHA02875 139 LHLAVMMGDIKGIE 152
PHA03095 PHA03095
ankyrin-like protein; Provisional
 98-150 3.42e-03

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 36.93  E-value: 3.42e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 145329951  98 LLKEGVDANYRDRQGMSVLHLAVLFNQTDIAL--MLMDHGASLEYKNAQGETPLD 150
Cdd:PHA03095 138 LLRKGADVNALDLYGMTPLAVLLKSRNANVELlrLLIDAGADVYAVDDRFRSLLH 192
PHA02946 PHA02946
ankyin-like protein; Provisional
 86-149 3.93e-03

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 36.96  E-value: 3.93e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 145329951  86 AIKNGDSAGAKKLLKEGVDANYRDRQGMSVLHLAVLFNQTDIALMLMDHGASLEYKNAQGETPL 149
Cdd:PHA02946  46 GIKGLDERFVEELLHRGYSPNETDDDGNYPLHIASKINNNRIVAMLLTHGADPNACDKQHKTPL 109
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 83-152 5.36e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 36.48  E-value: 5.36e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145329951  83 LREAIKNGDSAGAKKLLKEGVDANYRDRQGMSVLHLAVLFNQTDIALMLmdHGASLEYKNAQGETPLDCA 152
Cdd:PHA02874 194 LHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIHNRSAIELLI--NNASINDQDIDGSTPLHHA 261
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 83-149 5.53e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 36.40  E-value: 5.53e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 145329951  83 LREAIKNGDSAGAKKLLKEGVDANYRDRQGMSVLHLAVLF-NQTDIALMLMDHGASLEYKNA-QGETPL 149
Cdd:PHA02878 205 LHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHISVGYcKDYDILKLLLEHGVDVNAKSYiLGLTAL 273
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 85-149 5.70e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 36.12  E-value: 5.70e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 145329951  85 EAIKNGDSAGAKKLLKEGVDANYRDRQGMSVLHLAVLFNQTDIALMLMDHGASLEYKNAQGETPL 149
Cdd:PHA02875   8 DAILFGELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESEL 72
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 83-152 6.31e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 36.19  E-value: 6.31e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145329951  83 LREAIKNGDSAGAKKLLKEGVDANYRDRQGMSVLHLAVLFNQTDIALMLMDHGASLEYKNAQGETPLDCA 152
Cdd:PHA02876 149 IKERIQQDELLIAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECA 218
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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