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Conserved domains on  [gi|145323884|ref|NP_001077531|]
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fucosyltransferase 8 [Arabidopsis thaliana]

Protein Classification

O-fucosyltransferase family protein( domain architecture ID 94843)

O-fucosyltransferase family protein may be involved in glycan metabolism by O-fucosylation of protein substrates

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
O-FucT_like super family cl16914
GDP-fucose protein O-fucosyltransferase and related proteins; O-fucosyltransferase-like ...
13-490 0e+00

GDP-fucose protein O-fucosyltransferase and related proteins; O-fucosyltransferase-like proteins are GDP-fucose dependent enzymes with similarities to the family 1 glycosyltransferases (GT1). They are soluble ER proteins that may be proteolytically cleaved from a membrane-associated preprotein, and are involved in the O-fucosylation of protein substrates, the core fucosylation of growth factor receptors, and other processes.


The actual alignment was detected with superfamily member pfam03254:

Pssm-ID: 450121  Cd Length: 475  Bit Score: 607.75  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145323884   13 LLSVMQLSFfnifnyqlldatTNGSKDSR---KSKDKLLGGLLTADFDEDSCLSRYESSLYRKPSPYKPSRYLVSKLRSY 89
Cdd:pfam03254   2 KLSVMQGGF------------TTGSGFKNpagKPADELLGGLLAPGMDERSCLSRYQSAHYRKHFPHAPSPYLLSKLRAY 69
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145323884   90 EMLHKRCGPGTEAYKKATEILghddenHSTKSVG--ECRYIVWIAVYGLGNRILTLASLFLYALLTDRIMLVDQRTDISD 167
Cdd:pfam03254  70 EALHRRCGPGTPFYKKSLEQL------RSGRSAGgvECNYVVWLPFDGLGNRMLSMASAFLYALLTDRVLLVDLPHDSSD 143
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145323884  168 LFCEPFPGTSWLLPLDFPLTDQLDSFNKESPRCYGTMLKNHAINS----TTTESIIPSYLCLYLIHDYDDYDKMFFCESD 243
Cdd:pfam03254 144 LFCEPFPGASWLLPPDFPVANLFGSLGPRSEQSYTTLLNKKKITNdddpAATAALPPPPAYVYLSLGYQMADKLFFCGDD 223
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145323884  244 QILIRQVPWLVFNSNLYFIPSLWLIPSFQSELSKLFPQKETVFHHLARYLFHPTNQVWGMITRSYNGYLSRADERLGIQV 323
Cdd:pfam03254 224 QRALAKVNWLILYSDLYFVPSLFLVPEFEGELRRLFPAKETVFHLLGRYLFHPTNAVWGLITRYYNSYLAKASERIGIQI 303
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145323884  324 RVFSKPAGYFQHVMDQILACTQREKLLPEVFVLETQVT-----NTSRSSKLKAVLVTSLYPEYSEILRQMYWKGPSSTGE 398
Cdd:pfam03254 304 RMFNFASIPVDDLYNQILTCTRQEKILPEITDNDPTAYdsnssNGSGGGNSKAVLVASLYPDYYEKIRAMYYEHATRTRE 383
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145323884  399 IIQIYQPSQEIYQQTDNKLHDQKALAEIYLLSLTDYIVTSDSSTFGYVAQGLGGLKPWILYKPKNHTAPEPPCVRAVSME 478
Cdd:pfam03254 384 RVGVFQPTHEERQATQKQFHNQKALAEMLLLSFSDVLVTSGMSTFGYVGSGLAGVKPWILMPPHNHRAPAPPCRRAVSME 463
                         490
                  ....*....|..
gi 145323884  479 PCFLRAPLYGCQ 490
Cdd:pfam03254 464 PCFHAPPFYDCR 475
 
Name Accession Description Interval E-value
XG_FTase pfam03254
Xyloglucan fucosyltransferase; Plant cell walls are crucial for development, signal ...
13-490 0e+00

Xyloglucan fucosyltransferase; Plant cell walls are crucial for development, signal transduction, and disease resistance in plants. Cell walls are made of cellulose, hemicelluloses, and pectins. Xyloglucan (XG), the principal load-bearing hemicellulose of dicotyledonous plants, has a terminal fucosyl residue. This fucosyltransferase adds this residue.


Pssm-ID: 427220  Cd Length: 475  Bit Score: 607.75  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145323884   13 LLSVMQLSFfnifnyqlldatTNGSKDSR---KSKDKLLGGLLTADFDEDSCLSRYESSLYRKPSPYKPSRYLVSKLRSY 89
Cdd:pfam03254   2 KLSVMQGGF------------TTGSGFKNpagKPADELLGGLLAPGMDERSCLSRYQSAHYRKHFPHAPSPYLLSKLRAY 69
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145323884   90 EMLHKRCGPGTEAYKKATEILghddenHSTKSVG--ECRYIVWIAVYGLGNRILTLASLFLYALLTDRIMLVDQRTDISD 167
Cdd:pfam03254  70 EALHRRCGPGTPFYKKSLEQL------RSGRSAGgvECNYVVWLPFDGLGNRMLSMASAFLYALLTDRVLLVDLPHDSSD 143
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145323884  168 LFCEPFPGTSWLLPLDFPLTDQLDSFNKESPRCYGTMLKNHAINS----TTTESIIPSYLCLYLIHDYDDYDKMFFCESD 243
Cdd:pfam03254 144 LFCEPFPGASWLLPPDFPVANLFGSLGPRSEQSYTTLLNKKKITNdddpAATAALPPPPAYVYLSLGYQMADKLFFCGDD 223
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145323884  244 QILIRQVPWLVFNSNLYFIPSLWLIPSFQSELSKLFPQKETVFHHLARYLFHPTNQVWGMITRSYNGYLSRADERLGIQV 323
Cdd:pfam03254 224 QRALAKVNWLILYSDLYFVPSLFLVPEFEGELRRLFPAKETVFHLLGRYLFHPTNAVWGLITRYYNSYLAKASERIGIQI 303
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145323884  324 RVFSKPAGYFQHVMDQILACTQREKLLPEVFVLETQVT-----NTSRSSKLKAVLVTSLYPEYSEILRQMYWKGPSSTGE 398
Cdd:pfam03254 304 RMFNFASIPVDDLYNQILTCTRQEKILPEITDNDPTAYdsnssNGSGGGNSKAVLVASLYPDYYEKIRAMYYEHATRTRE 383
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145323884  399 IIQIYQPSQEIYQQTDNKLHDQKALAEIYLLSLTDYIVTSDSSTFGYVAQGLGGLKPWILYKPKNHTAPEPPCVRAVSME 478
Cdd:pfam03254 384 RVGVFQPTHEERQATQKQFHNQKALAEMLLLSFSDVLVTSGMSTFGYVGSGLAGVKPWILMPPHNHRAPAPPCRRAVSME 463
                         490
                  ....*....|..
gi 145323884  479 PCFLRAPLYGCQ 490
Cdd:pfam03254 464 PCFHAPPFYDCR 475
NodZ_like cd11548
Alpha 1,6-fucosyltransferase similar to Bradyrhizobium NodZ; Bradyrhizobium NodZ is an alpha 1, ...
135-452 6.25e-05

Alpha 1,6-fucosyltransferase similar to Bradyrhizobium NodZ; Bradyrhizobium NodZ is an alpha 1,6-fucosyltransferase involved in the biosynthesis of the nodulation factor, a lipo-chitooligosaccharide formed by three-to-six beta-1,4-linked N-acetyl-d-glucosamine (GlcNAc) residues and a fatty acid acyl group attached to the nitrogen atom at the non-reducing end. NodZ transfers L-fucose from the GDP-beta-L-fucose donor to the reducing residue of the chitin oligosaccharide backbone, before the attachment of a fatty acid group. O-fucosyltransferase-like proteins are GDP-fucose dependent enzymes with similarities to the family 1 glycosyltransferases (GT1). They are soluble ER proteins that may be proteolytically cleaved from a membrane-associated preprotein, and are involved in the O-fucosylation of protein substrates, the core fucosylation of growth factor receptors, and other processes.


Pssm-ID: 211389 [Multi-domain]  Cd Length: 287  Bit Score: 45.05  E-value: 6.25e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145323884 135 GLGNRILTLASLFLYALLTDRIMLVDQRTDisdlfcepfpgtsWLLPLD---FPLTdqldsFNKESPRCYGTMLknHAIN 211
Cdd:cd11548    9 GLGNRMLALASALELARLTGRTLVIDWRDY-------------EYAPRDenaFPLL-----FDPIEDRSIDGLP--DRDP 68
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145323884 212 STTTESIIPSYLCLYLIHDYDDYDKMF--FCESDQI--LIRQVPWLVFNSNLYFIPSLWLIPSFQSELSKLFpqketvfh 287
Cdd:cd11548   69 RRGTQNIKGYPQQWIRPTSDLSHRVPAqiFRECDELtvLDVKGRKAVQAGYLPKLPRDADKLGRDRGIIKCY-------- 140
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145323884 288 hLARYlFHPTNQVWGMITRSYNGYLSRAdeRLGIQVRVFSKPAGYF--QHVMDQILACTQREKLLPE---VFVletqvtn 362
Cdd:cd11548  141 -LYRL-FTPKQEVRAAVRKLYAKLFGRP--TIGVHIRTTDHKDSLFikLSPLHRVVDALRKKVALHKdatIFL------- 209
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145323884 363 TSRSSKLKavlvTSLYPEYSEILRQMYWKGPSSTgeiiqiyqpsqeiYQQTDNKLHDQKALAEIYLLSLTDYIVTSDSST 442
Cdd:cd11548  210 ATDSAEVK----DELKRLFPDVVVTPKEFPPHGE-------------RSASDGLEGAEDALIDMYLLARCDHLIGSRFST 272
                        330
                 ....*....|
gi 145323884 443 FGYVAQGLGG 452
Cdd:cd11548  273 FSRMASILGD 282
 
Name Accession Description Interval E-value
XG_FTase pfam03254
Xyloglucan fucosyltransferase; Plant cell walls are crucial for development, signal ...
13-490 0e+00

Xyloglucan fucosyltransferase; Plant cell walls are crucial for development, signal transduction, and disease resistance in plants. Cell walls are made of cellulose, hemicelluloses, and pectins. Xyloglucan (XG), the principal load-bearing hemicellulose of dicotyledonous plants, has a terminal fucosyl residue. This fucosyltransferase adds this residue.


Pssm-ID: 427220  Cd Length: 475  Bit Score: 607.75  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145323884   13 LLSVMQLSFfnifnyqlldatTNGSKDSR---KSKDKLLGGLLTADFDEDSCLSRYESSLYRKPSPYKPSRYLVSKLRSY 89
Cdd:pfam03254   2 KLSVMQGGF------------TTGSGFKNpagKPADELLGGLLAPGMDERSCLSRYQSAHYRKHFPHAPSPYLLSKLRAY 69
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145323884   90 EMLHKRCGPGTEAYKKATEILghddenHSTKSVG--ECRYIVWIAVYGLGNRILTLASLFLYALLTDRIMLVDQRTDISD 167
Cdd:pfam03254  70 EALHRRCGPGTPFYKKSLEQL------RSGRSAGgvECNYVVWLPFDGLGNRMLSMASAFLYALLTDRVLLVDLPHDSSD 143
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145323884  168 LFCEPFPGTSWLLPLDFPLTDQLDSFNKESPRCYGTMLKNHAINS----TTTESIIPSYLCLYLIHDYDDYDKMFFCESD 243
Cdd:pfam03254 144 LFCEPFPGASWLLPPDFPVANLFGSLGPRSEQSYTTLLNKKKITNdddpAATAALPPPPAYVYLSLGYQMADKLFFCGDD 223
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145323884  244 QILIRQVPWLVFNSNLYFIPSLWLIPSFQSELSKLFPQKETVFHHLARYLFHPTNQVWGMITRSYNGYLSRADERLGIQV 323
Cdd:pfam03254 224 QRALAKVNWLILYSDLYFVPSLFLVPEFEGELRRLFPAKETVFHLLGRYLFHPTNAVWGLITRYYNSYLAKASERIGIQI 303
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145323884  324 RVFSKPAGYFQHVMDQILACTQREKLLPEVFVLETQVT-----NTSRSSKLKAVLVTSLYPEYSEILRQMYWKGPSSTGE 398
Cdd:pfam03254 304 RMFNFASIPVDDLYNQILTCTRQEKILPEITDNDPTAYdsnssNGSGGGNSKAVLVASLYPDYYEKIRAMYYEHATRTRE 383
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145323884  399 IIQIYQPSQEIYQQTDNKLHDQKALAEIYLLSLTDYIVTSDSSTFGYVAQGLGGLKPWILYKPKNHTAPEPPCVRAVSME 478
Cdd:pfam03254 384 RVGVFQPTHEERQATQKQFHNQKALAEMLLLSFSDVLVTSGMSTFGYVGSGLAGVKPWILMPPHNHRAPAPPCRRAVSME 463
                         490
                  ....*....|..
gi 145323884  479 PCFLRAPLYGCQ 490
Cdd:pfam03254 464 PCFHAPPFYDCR 475
NodZ_like cd11548
Alpha 1,6-fucosyltransferase similar to Bradyrhizobium NodZ; Bradyrhizobium NodZ is an alpha 1, ...
135-452 6.25e-05

Alpha 1,6-fucosyltransferase similar to Bradyrhizobium NodZ; Bradyrhizobium NodZ is an alpha 1,6-fucosyltransferase involved in the biosynthesis of the nodulation factor, a lipo-chitooligosaccharide formed by three-to-six beta-1,4-linked N-acetyl-d-glucosamine (GlcNAc) residues and a fatty acid acyl group attached to the nitrogen atom at the non-reducing end. NodZ transfers L-fucose from the GDP-beta-L-fucose donor to the reducing residue of the chitin oligosaccharide backbone, before the attachment of a fatty acid group. O-fucosyltransferase-like proteins are GDP-fucose dependent enzymes with similarities to the family 1 glycosyltransferases (GT1). They are soluble ER proteins that may be proteolytically cleaved from a membrane-associated preprotein, and are involved in the O-fucosylation of protein substrates, the core fucosylation of growth factor receptors, and other processes.


Pssm-ID: 211389 [Multi-domain]  Cd Length: 287  Bit Score: 45.05  E-value: 6.25e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145323884 135 GLGNRILTLASLFLYALLTDRIMLVDQRTDisdlfcepfpgtsWLLPLD---FPLTdqldsFNKESPRCYGTMLknHAIN 211
Cdd:cd11548    9 GLGNRMLALASALELARLTGRTLVIDWRDY-------------EYAPRDenaFPLL-----FDPIEDRSIDGLP--DRDP 68
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145323884 212 STTTESIIPSYLCLYLIHDYDDYDKMF--FCESDQI--LIRQVPWLVFNSNLYFIPSLWLIPSFQSELSKLFpqketvfh 287
Cdd:cd11548   69 RRGTQNIKGYPQQWIRPTSDLSHRVPAqiFRECDELtvLDVKGRKAVQAGYLPKLPRDADKLGRDRGIIKCY-------- 140
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145323884 288 hLARYlFHPTNQVWGMITRSYNGYLSRAdeRLGIQVRVFSKPAGYF--QHVMDQILACTQREKLLPE---VFVletqvtn 362
Cdd:cd11548  141 -LYRL-FTPKQEVRAAVRKLYAKLFGRP--TIGVHIRTTDHKDSLFikLSPLHRVVDALRKKVALHKdatIFL------- 209
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145323884 363 TSRSSKLKavlvTSLYPEYSEILRQMYWKGPSSTgeiiqiyqpsqeiYQQTDNKLHDQKALAEIYLLSLTDYIVTSDSST 442
Cdd:cd11548  210 ATDSAEVK----DELKRLFPDVVVTPKEFPPHGE-------------RSASDGLEGAEDALIDMYLLARCDHLIGSRFST 272
                        330
                 ....*....|
gi 145323884 443 FGYVAQGLGG 452
Cdd:cd11548  273 FSRMASILGD 282
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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