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Conserved domains on  [gi|414144874|ref|NP_001070213|]
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1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon [Danio rerio]

Protein Classification

lysophospholipid acyltransferase family protein( domain architecture ID 10870651)

lysophospholipid acyltransferase (LPLAT) family protein may act as an acyltransferase of a de novo or remodeling pathway of glycerophospholipid biosynthesis, catalyzing the incorporation of an acyl group from either acyl-CoAs or acyl-acyl carrier proteins (acyl-ACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid

CATH:  1.10.1200.50
EC:  2.3.1.-
Gene Ontology:  GO:0016746|GO:0008654|GO:0006644
PubMed:  18287005|18931347|18718904|37611890
SCOP:  4003349

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LPLAT_LCLAT1-like cd07990
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; ...
 63-263 5.33e-79

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as Lysocardiolipin acyltransferase 1 (LCLAT1) or 1-acyl-sn-glycerol-3-phosphate acyltransferase and similar proteins.


:

Pssm-ID: 153252 [Multi-domain]  Cd Length: 193  Bit Score: 240.60  E-value: 5.33e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 414144874  63 LFFFENYTGVEIVIYGEIPK-KKENVVYLSNHQSTADWIIADMLAIRQNAIGHVRYVLKDGLKWLPLYGWYFSQHGGVYV 141
Cdd:cd07990    1 VFLFEWLSGVKVVVYGDEPKlPKERALIISNHRSEVDWLVLWMLADRFGRLGRLKIVLKDSLKYPPLGGWGWQLGEFIFL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 414144874 142 KRSANFDEKAMKKKLSSQTRLSTPMYLVIFPEGTRYNPELKKVisdSQAFAAKQGLAVLNHILTPRMKASHVAIETMREH 221
Cdd:cd07990   81 KRKWEKDEKTIKRQLKRLKDSPEPFWLLIFPEGTRFTEEKKER---SQEFAEKNGLPPLKHVLLPRTKGFVAILETLRDA 157

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 414144874 222 LDAVYDITVAYEGTLtadgqrrPAPTMPEFLCKECPRVHIHI 263
Cdd:cd07990  158 VDAVYDVTIAYPDGK-------PPSEQRLLLGGKPREVHVHV 192
Acyltransf_C pfam16076
Acyltransferase C-terminus; This domain is found at the C-terminus of several different ...
 258-328 1.17e-10

Acyltransferase C-terminus; This domain is found at the C-terminus of several different acyltransferases including 1-acyl-sn-glycerol-3-phosphate acyltransferase, acyl-CoA:lysophosphatidylglycerol acyltransferase 1 and lysocardiolipin acyltransferase 1.


:

Pssm-ID: 465006 [Multi-domain]  Cd Length: 74  Bit Score: 56.81  E-value: 1.17e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 414144874  258 RVHIHISRVDIKDIPAEPDVFRGWLHQRFEIKDKLLTTFYEsedpaKKSRFPGEGRKSPlSLSKTLPSLLI 328
Cdd:pfam16076   9 EVHMYIRRIPLEELPEDEEELAQWLHDLFVEKDKLLDYFYE-----TGTFFPGKEHIIP-RRLKSLLVFIF 73
 
Name Accession Description Interval E-value
LPLAT_LCLAT1-like cd07990
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; ...
 63-263 5.33e-79

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as Lysocardiolipin acyltransferase 1 (LCLAT1) or 1-acyl-sn-glycerol-3-phosphate acyltransferase and similar proteins.


Pssm-ID: 153252 [Multi-domain]  Cd Length: 193  Bit Score: 240.60  E-value: 5.33e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 414144874  63 LFFFENYTGVEIVIYGEIPK-KKENVVYLSNHQSTADWIIADMLAIRQNAIGHVRYVLKDGLKWLPLYGWYFSQHGGVYV 141
Cdd:cd07990    1 VFLFEWLSGVKVVVYGDEPKlPKERALIISNHRSEVDWLVLWMLADRFGRLGRLKIVLKDSLKYPPLGGWGWQLGEFIFL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 414144874 142 KRSANFDEKAMKKKLSSQTRLSTPMYLVIFPEGTRYNPELKKVisdSQAFAAKQGLAVLNHILTPRMKASHVAIETMREH 221
Cdd:cd07990   81 KRKWEKDEKTIKRQLKRLKDSPEPFWLLIFPEGTRFTEEKKER---SQEFAEKNGLPPLKHVLLPRTKGFVAILETLRDA 157

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 414144874 222 LDAVYDITVAYEGTLtadgqrrPAPTMPEFLCKECPRVHIHI 263
Cdd:cd07990  158 VDAVYDVTIAYPDGK-------PPSEQRLLLGGKPREVHVHV 192
PLN02510 PLN02510
probable 1-acyl-sn-glycerol-3-phosphate acyltransferase
 60-333 2.05e-54

probable 1-acyl-sn-glycerol-3-phosphate acyltransferase


Pssm-ID: 178126 [Multi-domain]  Cd Length: 374  Bit Score: 183.36  E-value: 2.05e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 414144874  60 SMVLFFFENYTGVEIVIYGEIPKKKENVVYLSNHQSTADWIIADMLAIRQNAIGHVRYVLKDGLKWLPLYGWYFSQHGGV 139
Cdd:PLN02510  67 ALWPFLFEKINKTKVVFSGDKVPPEERVLLIANHRTEVDWMYLWDLALRKGCLGYIKYVLKSSLMKLPVFGWAFHIFEFI 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 414144874 140 YVKRSANFDEKAMKKKLSSQTRLSTPMYLVIFPEGTRYNpELKKVisDSQAFAAKQGLAVLNHILTPRMKASHVAIETMR 219
Cdd:PLN02510 147 PVERKWEVDEPNIRQMLSSFKDPRDPLWLALFPEGTDYT-EAKCQ--RSQKFAAEHGLPILNNVLLPKTKGFVSCLQELR 223

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 414144874 220 EHLDAVYDITVAYEgtltadgqrrpaPTMPEFLCK----ECPRVHIHISRVDIKDIPAEPDVFRGWLHQRFEIKDKLLTT 295
Cdd:PLN02510 224 CSLDAVYDVTIGYK------------HRCPSFLDNvfgiDPSEVHIHIRRIPLKQIPTSEDEVSAWLMDRFQLKDQLLSD 291

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 414144874 296 FYesedpaKKSRFPGEGRKSPLSLSKTLPSLLILSGLT 333
Cdd:PLN02510 292 FY------AQGHFPNEGTEGELSTLKCLANFLAVIALT 323
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
 87-204 1.92e-19

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 82.79  E-value: 1.92e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 414144874    87 VVYLSNHQSTADWIIadMLAIRQNAIGHVRYVLKDGLKWLPLYGWYFSQHGGVYVKRSANF-DEKAMKKKLSsqtRLSTP 165
Cdd:smart00563   1 ALVVANHQSFLDPLV--LSALLPRKLGRVRFVAKKELFYVPLLGWLLRLLGAIFIDRSNGRkARAALREAVE---LLKEG 75

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 414144874   166 MYLVIFPEGTRYNPELkkvISDSQAFAAKQGLAVLNHIL 204
Cdd:smart00563  76 EWLLIFPEGTRSRPGK---LLPFKKGAARLALEAGVPIV 111
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 71-176 9.71e-15

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 72.35  E-value: 9.71e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 414144874  71 GVEIVIYG-EIPKKKENVVYLSNHQSTADWIIAdMLAIRQnaigHVRYVLKDGLKWLPLYGWYFSQHGGVYVKRSANF-D 148
Cdd:COG0204   28 GVRVRVEGlENLPADGPVLIVANHQSWLDILLL-LAALPR----PVRFVAKKELFKIPLLGWLLRALGAIPVDRSKRRaA 102

                         90       100
                 ....*....|....*....|....*...
gi 414144874 149 EKAMKKklsSQTRLSTPMYLVIFPEGTR 176
Cdd:COG0204  103 LRALRQ---AVEALKAGESLVIFPEGTR 127
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
 83-176 2.88e-12

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 63.45  E-value: 2.88e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 414144874   83 KKENVVYLSNHQSTADWIIADMLAIRQNAIghVRYVLKDGLKWLPLYGWYFSQHGGVYVKRSANFDEKAMKKKLSSqtRL 162
Cdd:pfam01553  12 RGGPAIVVANHQSYLDVLLLSLALYKRGRP--LVFVAKKELFDIPLVGWLMRLLGCIFIDRKNRKDAAGTLEYLVE--LL 87

                          90
                  ....*....|....
gi 414144874  163 STPMYLVIFPEGTR 176
Cdd:pfam01553  88 REGKLVVIFPEGTR 101
Acyltransf_C pfam16076
Acyltransferase C-terminus; This domain is found at the C-terminus of several different ...
 258-328 1.17e-10

Acyltransferase C-terminus; This domain is found at the C-terminus of several different acyltransferases including 1-acyl-sn-glycerol-3-phosphate acyltransferase, acyl-CoA:lysophosphatidylglycerol acyltransferase 1 and lysocardiolipin acyltransferase 1.


Pssm-ID: 465006 [Multi-domain]  Cd Length: 74  Bit Score: 56.81  E-value: 1.17e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 414144874  258 RVHIHISRVDIKDIPAEPDVFRGWLHQRFEIKDKLLTTFYEsedpaKKSRFPGEGRKSPlSLSKTLPSLLI 328
Cdd:pfam16076   9 EVHMYIRRIPLEELPEDEEELAQWLHDLFVEKDKLLDYFYE-----TGTFFPGKEHIIP-RRLKSLLVFIF 73
AGP_acyltrn TIGR00530
1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous ...
 71-176 1.25e-09

1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous region of a collection of related proteins, several of which are known to act as 1-acyl-sn-glycerol-3-phosphate acyltransferases (EC 2.3.1.51). Proteins scoring above the trusted cutoff are likely to have the same general activity. However, there is variation among characterized members as to whether the acyl group can be donated by acyl carrier protein or coenzyme A, and in the length and saturation of the donated acyl group. 1-acyl-sn-glycerol-3-phosphate acyltransferase is also called 1-AGP acyltransferase, lysophosphatidic acid acyltransferase, and LPA acyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 129621 [Multi-domain]  Cd Length: 130  Bit Score: 55.82  E-value: 1.25e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 414144874   71 GVEIVIYG-EIPKKKENVVYLSNHQSTADWIIadMLAIRQNAIghvRYVLKDGLKWLPLYGWYFSQHGGVYVKRSANFDE 149
Cdd:TIGR00530   1 GLKVEVVGpENLPAKSPVLVVANHQSNLDPLT--LSAAFPPPI---VFIAKKELKWIPFFGIMLWLTGAIFIDRENIRAI 75

                          90       100
                  ....*....|....*....|....*..
gi 414144874  150 KAMKKKLSSQTRLSTPmyLVIFPEGTR 176
Cdd:TIGR00530  76 ATALKAAIEVLKQGRS--IGVFPEGTR 100
 
Name Accession Description Interval E-value
LPLAT_LCLAT1-like cd07990
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; ...
 63-263 5.33e-79

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as Lysocardiolipin acyltransferase 1 (LCLAT1) or 1-acyl-sn-glycerol-3-phosphate acyltransferase and similar proteins.


Pssm-ID: 153252 [Multi-domain]  Cd Length: 193  Bit Score: 240.60  E-value: 5.33e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 414144874  63 LFFFENYTGVEIVIYGEIPK-KKENVVYLSNHQSTADWIIADMLAIRQNAIGHVRYVLKDGLKWLPLYGWYFSQHGGVYV 141
Cdd:cd07990    1 VFLFEWLSGVKVVVYGDEPKlPKERALIISNHRSEVDWLVLWMLADRFGRLGRLKIVLKDSLKYPPLGGWGWQLGEFIFL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 414144874 142 KRSANFDEKAMKKKLSSQTRLSTPMYLVIFPEGTRYNPELKKVisdSQAFAAKQGLAVLNHILTPRMKASHVAIETMREH 221
Cdd:cd07990   81 KRKWEKDEKTIKRQLKRLKDSPEPFWLLIFPEGTRFTEEKKER---SQEFAEKNGLPPLKHVLLPRTKGFVAILETLRDA 157

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 414144874 222 LDAVYDITVAYEGTLtadgqrrPAPTMPEFLCKECPRVHIHI 263
Cdd:cd07990  158 VDAVYDVTIAYPDGK-------PPSEQRLLLGGKPREVHVHV 192
PLN02510 PLN02510
probable 1-acyl-sn-glycerol-3-phosphate acyltransferase
 60-333 2.05e-54

probable 1-acyl-sn-glycerol-3-phosphate acyltransferase


Pssm-ID: 178126 [Multi-domain]  Cd Length: 374  Bit Score: 183.36  E-value: 2.05e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 414144874  60 SMVLFFFENYTGVEIVIYGEIPKKKENVVYLSNHQSTADWIIADMLAIRQNAIGHVRYVLKDGLKWLPLYGWYFSQHGGV 139
Cdd:PLN02510  67 ALWPFLFEKINKTKVVFSGDKVPPEERVLLIANHRTEVDWMYLWDLALRKGCLGYIKYVLKSSLMKLPVFGWAFHIFEFI 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 414144874 140 YVKRSANFDEKAMKKKLSSQTRLSTPMYLVIFPEGTRYNpELKKVisDSQAFAAKQGLAVLNHILTPRMKASHVAIETMR 219
Cdd:PLN02510 147 PVERKWEVDEPNIRQMLSSFKDPRDPLWLALFPEGTDYT-EAKCQ--RSQKFAAEHGLPILNNVLLPKTKGFVSCLQELR 223

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 414144874 220 EHLDAVYDITVAYEgtltadgqrrpaPTMPEFLCK----ECPRVHIHISRVDIKDIPAEPDVFRGWLHQRFEIKDKLLTT 295
Cdd:PLN02510 224 CSLDAVYDVTIGYK------------HRCPSFLDNvfgiDPSEVHIHIRRIPLKQIPTSEDEVSAWLMDRFQLKDQLLSD 291

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 414144874 296 FYesedpaKKSRFPGEGRKSPLSLSKTLPSLLILSGLT 333
Cdd:PLN02510 292 FY------AQGHFPNEGTEGELSTLKCLANFLAVIALT 323
PLN02380 PLN02380
1-acyl-sn-glycerol-3-phosphate acyltransferase
 45-334 4.49e-40

1-acyl-sn-glycerol-3-phosphate acyltransferase


Pssm-ID: 178006 [Multi-domain]  Cd Length: 376  Bit Score: 145.27  E-value: 4.49e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 414144874  45 RLYHTVDDRAYSVYQSMVLFFFENYTGVEIVIYGEIPKK----KENVVYLSNHQSTADWIIADMLAIRQNAIGHVRYVLK 120
Cdd:PLN02380  40 SLYRRINRAVAELLWLELIWLVDWWAGVKVQLYADEETFelmgKEHALVISNHRSDIDWLVGWILAQRSGCLGSALAVMK 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 414144874 121 DGLKWLPLYGW--YFSQHggVYVKRSANFDEKAMKKKLSSQTRLSTPMYLVIFPEGTRYNPElkKVISdSQAFAAKQGLA 198
Cdd:PLN02380 120 KSSKFLPVIGWsmWFSEY--VFLERSWAKDENTLKSGFQRLKDFPRPFWLALFVEGTRFTQA--KLLA-AQEYAASRGLP 194

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 414144874 199 VLNHILTPRMKASHVAIETMREHLDAVYDITVAYEGTLtadgqrrPAPTMPEFLCKECPRVHIHISRVDIKDIPAEPDVF 278
Cdd:PLN02380 195 VPRNVLIPRTKGFVSAVSNMRSFVPAIYDVTVAVPKGQ-------PAPTMLRIFRGQSSVVHVHIKRHSMKELPETDDGI 267

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 414144874 279 RGWLHQRFEIKDKLLTTfYESEDPAKKSRFPGEGR-KSPLSLSKTLPSLLILSGLTF 334
Cdd:PLN02380 268 AQWCKDVFVAKDALLDK-HFAEDTFGDQEYQDIGRpKKSLIVVISWACLLILGAIKF 323
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
 87-204 1.92e-19

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 82.79  E-value: 1.92e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 414144874    87 VVYLSNHQSTADWIIadMLAIRQNAIGHVRYVLKDGLKWLPLYGWYFSQHGGVYVKRSANF-DEKAMKKKLSsqtRLSTP 165
Cdd:smart00563   1 ALVVANHQSFLDPLV--LSALLPRKLGRVRFVAKKELFYVPLLGWLLRLLGAIFIDRSNGRkARAALREAVE---LLKEG 75

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 414144874   166 MYLVIFPEGTRYNPELkkvISDSQAFAAKQGLAVLNHIL 204
Cdd:smart00563  76 EWLLIFPEGTRSRPGK---LLPFKKGAARLALEAGVPIV 111
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 71-176 9.71e-15

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 72.35  E-value: 9.71e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 414144874  71 GVEIVIYG-EIPKKKENVVYLSNHQSTADWIIAdMLAIRQnaigHVRYVLKDGLKWLPLYGWYFSQHGGVYVKRSANF-D 148
Cdd:COG0204   28 GVRVRVEGlENLPADGPVLIVANHQSWLDILLL-LAALPR----PVRFVAKKELFKIPLLGWLLRALGAIPVDRSKRRaA 102

                         90       100
                 ....*....|....*....|....*...
gi 414144874 149 EKAMKKklsSQTRLSTPMYLVIFPEGTR 176
Cdd:COG0204  103 LRALRQ---AVEALKAGESLVIFPEGTR 127
LPLAT_AGPAT-like cd07989
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; ...
 70-176 5.52e-14

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.


Pssm-ID: 153251 [Multi-domain]  Cd Length: 184  Bit Score: 69.61  E-value: 5.52e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 414144874  70 TGVEIVIYG-EIPKKKENVVYLSNHQSTADWIIAdMLAIRqnaiGHVRYVLKDGLKWLPLYGWYFSQHGGVYVKRSANF- 147
Cdd:cd07989    8 LGVRVRVEGlENLPPKGPVIIVANHQSYLDPLVL-GAALP----RPIRFVAKKELFKIPFLGWLLRLLGAIPIDRGNGRs 82

                         90       100
                 ....*....|....*....|....*....
gi 414144874 148 DEKAMKKklsSQTRLSTPMYLVIFPEGTR 176
Cdd:cd07989   83 AREALRE---AIEALKEGESVVIFPEGTR 108
PRK14014 PRK14014
putative acyltransferase; Provisional
 89-304 2.11e-13

putative acyltransferase; Provisional


Pssm-ID: 237584 [Multi-domain]  Cd Length: 301  Bit Score: 69.88  E-value: 2.11e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 414144874  89 YL--SNHQSTADwiIADMLAIRQNAIGHVRYVLKDGLKWLPLYG--WYF------SQHGGVYVKRS---ANFDEKAMKK- 154
Cdd:PRK14014  89 YLviSNHQSWVD--ILVLQYVFNRRIPMLKFFLKQELIWVPFLGlaWWAldfpfmKRYSKAYLAKNpelKGKDLETTRRa 166

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 414144874 155 --KLSSQtrlstPMYLVIFPEGTRYNPElKKVISDSQafaakqglavLNHILTPrmKASHVA--IETMREHLDAVYDITV 230
Cdd:PRK14014 167 ceKFKRM-----PTTIVNFVEGTRFTPE-KHQQQQSP----------YQHLLKP--KAGGIAfaLNAMGEQFDGLLDVTI 228

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 414144874 231 AYEGtltadgqrrPAPTMPEFLCKECPRVHIHISRVDIkdipaePDVFRG--------------WLHQRFEIKDKLLTTF 296
Cdd:PRK14014 229 VYPD---------GRPSFWDLLSGRVKKIVVHVRLLPI------PEELIGdyfndkefrrrfqqWLNQLWQEKDQLIEQL 293


                 ....*...
gi 414144874 297 YESEDPAK 304
Cdd:PRK14014 294 LAQYNQNK 301
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
 83-176 2.88e-12

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 63.45  E-value: 2.88e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 414144874   83 KKENVVYLSNHQSTADWIIADMLAIRQNAIghVRYVLKDGLKWLPLYGWYFSQHGGVYVKRSANFDEKAMKKKLSSqtRL 162
Cdd:pfam01553  12 RGGPAIVVANHQSYLDVLLLSLALYKRGRP--LVFVAKKELFDIPLVGWLMRLLGCIFIDRKNRKDAAGTLEYLVE--LL 87

                          90
                  ....*....|....
gi 414144874  163 STPMYLVIFPEGTR 176
Cdd:pfam01553  88 REGKLVVIFPEGTR 101
Acyltransf_C pfam16076
Acyltransferase C-terminus; This domain is found at the C-terminus of several different ...
 258-328 1.17e-10

Acyltransferase C-terminus; This domain is found at the C-terminus of several different acyltransferases including 1-acyl-sn-glycerol-3-phosphate acyltransferase, acyl-CoA:lysophosphatidylglycerol acyltransferase 1 and lysocardiolipin acyltransferase 1.


Pssm-ID: 465006 [Multi-domain]  Cd Length: 74  Bit Score: 56.81  E-value: 1.17e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 414144874  258 RVHIHISRVDIKDIPAEPDVFRGWLHQRFEIKDKLLTTFYEsedpaKKSRFPGEGRKSPlSLSKTLPSLLI 328
Cdd:pfam16076   9 EVHMYIRRIPLEELPEDEEELAQWLHDLFVEKDKLLDYFYE-----TGTFFPGKEHIIP-RRLKSLLVFIF 73
AGP_acyltrn TIGR00530
1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous ...
 71-176 1.25e-09

1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous region of a collection of related proteins, several of which are known to act as 1-acyl-sn-glycerol-3-phosphate acyltransferases (EC 2.3.1.51). Proteins scoring above the trusted cutoff are likely to have the same general activity. However, there is variation among characterized members as to whether the acyl group can be donated by acyl carrier protein or coenzyme A, and in the length and saturation of the donated acyl group. 1-acyl-sn-glycerol-3-phosphate acyltransferase is also called 1-AGP acyltransferase, lysophosphatidic acid acyltransferase, and LPA acyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 129621 [Multi-domain]  Cd Length: 130  Bit Score: 55.82  E-value: 1.25e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 414144874   71 GVEIVIYG-EIPKKKENVVYLSNHQSTADWIIadMLAIRQNAIghvRYVLKDGLKWLPLYGWYFSQHGGVYVKRSANFDE 149
Cdd:TIGR00530   1 GLKVEVVGpENLPAKSPVLVVANHQSNLDPLT--LSAAFPPPI---VFIAKKELKWIPFFGIMLWLTGAIFIDRENIRAI 75

                          90       100
                  ....*....|....*....|....*..
gi 414144874  150 KAMKKKLSSQTRLSTPmyLVIFPEGTR 176
Cdd:TIGR00530  76 ATALKAAIEVLKQGRS--IGVFPEGTR 100
LPLAT_LPCAT1-like cd07991
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like; ...
 61-175 9.75e-07

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as lysophosphatidylcholine acyltransferase 1 (LPCAT-1), glycerol-3-phosphate acyltransferase 3 (GPAT3), and similar sequences.


Pssm-ID: 153253 [Multi-domain]  Cd Length: 211  Bit Score: 49.14  E-value: 9.75e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 414144874  61 MVLFFFENYTgveIVIYGEIPKKKENVVYLSNHQSTADWIIADMlairqnaIGHVRYVLKDGLKWLPLYGWYFSQHGGVY 140
Cdd:cd07991    3 VLLFAFGFYV---IKVHGKPDPPEAPRIIVANHTSFIDPLILFS-------DLFPSIVAKKELGKLPFIGTILRALGCIF 72

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 414144874 141 VKRSANFDEKAMKKKLSSQTRLSTPMYLVIFPEGT 175
Cdd:cd07991   73 VDRSEPKDRKKVVEEIKERATDPNWPPILIFPEGT 107
LPLAT_ABO13168-like cd07988
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ...
 76-182 2.12e-06

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are uncharacterized phospholipid/glycerol acyltransferases such as the Acinetobacter baumannii ATCC 17978 locus ABO13168 putative acyltransferase, and similar proteins.


Pssm-ID: 153250 [Multi-domain]  Cd Length: 163  Bit Score: 47.21  E-value: 2.12e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 414144874  76 IYGEIPKKKENVVYLSNHQSTADWIIAdMLAIRQNAIGhVRYVLKDGLKWLPLyGWYFSQHGGVYVKRSANFDE-KAMKK 154
Cdd:cd07988   12 IEGEPPNKPKFVVIGAPHTSNWDFVLG-LLAAFALGLK-ISFLGKHSLFKPPL-GPFMRWLGGIPVDRSRAGGLvEQVVE 88

                         90       100
                 ....*....|....*....|....*....
gi 414144874 155 KLSSQTRLStpmyLVIFPEGTR-YNPELK 182
Cdd:cd07988   89 EFRRREEFV----LAIAPEGTRsKVDKWK 113
PLN02833 PLN02833
glycerol acyltransferase family protein
 59-180 6.86e-04

glycerol acyltransferase family protein


Pssm-ID: 215447  Cd Length: 376  Bit Score: 41.30  E-value: 6.86e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 414144874  59 QSMVLFFFENYTGVeIVIYGEIPKKKENVVYLSNHQSTADWIIADML----AIRQNAIGHVRYVLKDGLKWLplygwyfs 134
Cdd:PLN02833 138 ELICSAFVASWTGV-IKYHGPRPSRRPKQVFVANHTSMIDFIVLEQMtpfaVIMQKHPGWVGFLQNTILESV-------- 208

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 414144874 135 qhGGVYVKRSANFDEKAMKKKLSSQTRLSTPMYLVIFPEGTRYNPE 180
Cdd:PLN02833 209 --GCIWFNRTEAKDREVVAKKLRDHVQDPDRNPLLIFPEGTCVNNE 252
LPLAT cd06551
Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; ...
 61-176 1.86e-03

Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Lysophospholipid acyltransferase (LPLAT) superfamily members are acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis. These proteins catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this superfamily are LPLATs such as glycerol-3-phosphate 1-acyltransferase (GPAT, PlsB), 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), lysophosphatidylcholine acyltransferase 1 (LPCAT-1), lysophosphatidylethanolamine acyltransferase (LPEAT, also known as, MBOAT2, membrane-bound O-acyltransferase domain-containing protein 2), lipid A biosynthesis lauroyl/myristoyl acyltransferase, 2-acylglycerol O-acyltransferase (MGAT), dihydroxyacetone phosphate acyltransferase (DHAPAT, also known as 1 glycerol-3-phosphate O-acyltransferase 1) and Tafazzin (the protein product of the Barth syndrome (TAZ) gene).


Pssm-ID: 153244 [Multi-domain]  Cd Length: 187  Bit Score: 38.93  E-value: 1.86e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 414144874  61 MVLFFFENYTGVEIVIYG-EIPKKKENVVYLSNHQSTADWIIAdMLAIRQNAIGHVRYVLKDGLKwlpLYGWYFSQHGGV 139
Cdd:cd06551    1 FRYLLLNFFGFVRLEVKGpPPPPGGGPVLFVSNHSSWWDGLIL-FLLLERGLRRDVYGLMDEELL---ERYPFFTRLGAF 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 414144874 140 YVKRS----ANFDEKAMKKKLSSQTRLstpmyLVIFPEGTR 176
Cdd:cd06551   77 SVDRDsprsAAKSLKYVARLLSKPGSV-----VWIFPEGTR 112
PLN02901 PLN02901
1-acyl-sn-glycerol-3-phosphate acyltransferase
 62-176 3.03e-03

1-acyl-sn-glycerol-3-phosphate acyltransferase


Pssm-ID: 215488 [Multi-domain]  Cd Length: 214  Bit Score: 38.56  E-value: 3.03e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 414144874  62 VLFFFEnytgVEIVIYGEIPKKKENVVYLSNHQSTADwiIADMLAIRQNaighVRYVLKDGLKWLPLYGWYFSQHGGVYV 141
Cdd:PLN02901  31 TSPFYK----IEVEGLENLPSPDEPAVYVSNHQSFLD--IYTLFHLGRP----FKFISKTSIFLIPIIGWAMYMTGHIPL 100

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 414144874 142 KRsanfdekaMKKKlsSQTR-LSTPMYLV-------IFPEGTR 176
Cdd:PLN02901 101 KR--------MDRR--SQLEcLKRCMELLkkgasvfFFPEGTR 133
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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