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Conserved domains on  [gi|115532296|ref|NP_001040663|]
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Sodium/calcium exchanger membrane region domain-containing protein [Caenorhabditis elegans]

Protein Classification

putative sodium/potassium/calcium exchanger( domain architecture ID 1001229)

putative sodium/potassium/calcium exchanger

Gene Ontology:  GO:0005886|GO:0015293|GO:0006811
PubMed:  15163769
TCDB:  2.A.19

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
2A1904 super family cl36772
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 48-594 3.78e-167

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


The actual alignment was detected with superfamily member TIGR00927:

Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 504.91  E-value: 3.78e-167
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532296    48 IITPENTPVNASKPFWKTLL----PTCNRSLAPPA-PDVNDDGQFPPDPFSLEQRQNGFVVLHMCGLIYMFVSLAIVCDE 122
Cdd:TIGR00927  398 VVKPAPAVPTTPSPSLTTALfpeaPSPSPSALPPGqPDLHPKAEYPPDLFSVEERRQGWVVLHIFGMMYVFVALAIVCDE 477

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532296   123 FFVPSLDVLTEKLSLSDDVAGATFMAAGGSAPEFFTSVIGVFIAQNNVGIGTIVGSATFNILCVLAFCTLFSKSILDLTW 202
Cdd:TIGR00927  478 YFVPALGVITDKLQISEDVAGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNILFVIGTCALFSREILNLTW 557

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532296   203 WPLFRDVSIYMLALAMLVFFFMDEMITFPEALAMFSIYIVYCTVMKFNGQLEQLVKK----------------------- 259
Cdd:TIGR00927  558 WPLFRDVSFYILDLMMLILFFLDSLIAWWESLLLLLAYALYVFTMKWNKQIELWVKEqlsrrpvakvmalgdlskgdvae 637

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532296   260 --------------------------GSDSEEASAHETQ---KLAADVPHNNNNNDLAQLEGSELRRRSSARRQSVPILH 310
Cdd:TIGR00927  638 aehtgertgeegerpteaegengeesGGEAEQEGETETKgenESEGEIPAERKGEQEGEGEIEAKEADHKGETEAEEVEH 717

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532296   311 SG----------------------------------TMFRNGIMQLMNQTLEQLPEDSEEDDSSRSRSNVNIE------- 349
Cdd:TIGR00927  718 EGeteaegtedegeietgeegeevedegegeaegkhEVETEGDRKETEHEGETEAEGKEDEDEGEIQAGEDGEmkgdega 797

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532296   350 ------------------------------------SHDMHRLNVNQSMPDRR-------------------------SS 368
Cdd:TIGR00927  798 egkvehegeteagekdehegqsetqaddtevkdetgEQELNAENQGEAKQDEKgvdggggsdggdseeeeeeeeeeeeEE 877

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532296   369 QIEEIKSLLEEQEEKPLDMTWPETWVKRLTYVLLAPVVIPMWVTIPDVRKSHNRGLYPATFIISILWIAFFSYLMVWWAN 448
Cdd:TIGR00927  878 EEEEEEEEEEEENEEPLSLEWPETRQKQAIYLFLLPIVFPLWLTVPDVRRQEARKFFVITFLGSIMWIAMFSYLMVWWAH 957

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532296   449 TIGETFVIPTEIIGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDVCVGLPIPWLLYFLIeyikhpnEPLSP 528
Cdd:TIGR00927  958 QVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPVPWLLFSLI-------NGLQP 1030

                          650       660       670       680       690       700
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 115532296   529 ISVSSKGLLCSVGMLFIMLIVLVFAIFLSGWKMNKIFGILMIVSYVFFCVFSVSLETDKLVCPLNI 594
Cdd:TIGR00927 1031 VPVSSNGLFCAIVLLFLMLLFVISSIASCKWRMNKILGFTMFLLYFVFLIISVMLEDRIISCPVSV 1096
 
Name Accession Description Interval E-value
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 48-594 3.78e-167

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 504.91  E-value: 3.78e-167
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532296    48 IITPENTPVNASKPFWKTLL----PTCNRSLAPPA-PDVNDDGQFPPDPFSLEQRQNGFVVLHMCGLIYMFVSLAIVCDE 122
Cdd:TIGR00927  398 VVKPAPAVPTTPSPSLTTALfpeaPSPSPSALPPGqPDLHPKAEYPPDLFSVEERRQGWVVLHIFGMMYVFVALAIVCDE 477

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532296   123 FFVPSLDVLTEKLSLSDDVAGATFMAAGGSAPEFFTSVIGVFIAQNNVGIGTIVGSATFNILCVLAFCTLFSKSILDLTW 202
Cdd:TIGR00927  478 YFVPALGVITDKLQISEDVAGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNILFVIGTCALFSREILNLTW 557

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532296   203 WPLFRDVSIYMLALAMLVFFFMDEMITFPEALAMFSIYIVYCTVMKFNGQLEQLVKK----------------------- 259
Cdd:TIGR00927  558 WPLFRDVSFYILDLMMLILFFLDSLIAWWESLLLLLAYALYVFTMKWNKQIELWVKEqlsrrpvakvmalgdlskgdvae 637

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532296   260 --------------------------GSDSEEASAHETQ---KLAADVPHNNNNNDLAQLEGSELRRRSSARRQSVPILH 310
Cdd:TIGR00927  638 aehtgertgeegerpteaegengeesGGEAEQEGETETKgenESEGEIPAERKGEQEGEGEIEAKEADHKGETEAEEVEH 717

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532296   311 SG----------------------------------TMFRNGIMQLMNQTLEQLPEDSEEDDSSRSRSNVNIE------- 349
Cdd:TIGR00927  718 EGeteaegtedegeietgeegeevedegegeaegkhEVETEGDRKETEHEGETEAEGKEDEDEGEIQAGEDGEmkgdega 797

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532296   350 ------------------------------------SHDMHRLNVNQSMPDRR-------------------------SS 368
Cdd:TIGR00927  798 egkvehegeteagekdehegqsetqaddtevkdetgEQELNAENQGEAKQDEKgvdggggsdggdseeeeeeeeeeeeEE 877

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532296   369 QIEEIKSLLEEQEEKPLDMTWPETWVKRLTYVLLAPVVIPMWVTIPDVRKSHNRGLYPATFIISILWIAFFSYLMVWWAN 448
Cdd:TIGR00927  878 EEEEEEEEEEEENEEPLSLEWPETRQKQAIYLFLLPIVFPLWLTVPDVRRQEARKFFVITFLGSIMWIAMFSYLMVWWAH 957

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532296   449 TIGETFVIPTEIIGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDVCVGLPIPWLLYFLIeyikhpnEPLSP 528
Cdd:TIGR00927  958 QVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPVPWLLFSLI-------NGLQP 1030

                          650       660       670       680       690       700
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 115532296   529 ISVSSKGLLCSVGMLFIMLIVLVFAIFLSGWKMNKIFGILMIVSYVFFCVFSVSLETDKLVCPLNI 594
Cdd:TIGR00927 1031 VPVSSNGLFCAIVLLFLMLLFVISSIASCKWRMNKILGFTMFLLYFVFLIISVMLEDRIISCPVSV 1096
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
122-579 5.78e-38

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 141.81  E-value: 5.78e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532296 122 EFFVPSLDVLTEKLSLSDDVAGATFMAAGGSAPEFFTSVIGVFIAQNNVGIGTIVGSATFNILCVLAFCTLFSKSILDLT 201
Cdd:COG0530    2 DLLVRGADALARRLGISPLVIGLTIVAFGTSLPELAVSVTAALDGSPDIAVGNVVGSNIANILLILGLAALIRPLAVDRR 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532296 202 WwpLFRDVSIYMLALAMLVFFFMDEMITFPEALAMFSIYIVYctvmkfngqleqlvkkgsdseeasahetqklaadvphn 281
Cdd:COG0530   82 V--LRRDLPFLLLASLLLLALLLDGTLSRIDGVILLLLYVLY-------------------------------------- 121

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532296 282 nnnndlaqlegselrrrssarrqsvpilhsgtmfrngIMQLMNQTLEQLPEDSEEDDssrsrsnvnieshdmhrlnvnqs 361
Cdd:COG0530  122 -------------------------------------LYYLIRRARKEPAWEEVEEE----------------------- 141

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532296 362 mpdrrssqieeikslleeqEEKPLDMTWPETWVKrltyvllapvvipmwvtipdvrkshnrglypatFIISILWIAFFSY 441
Cdd:COG0530  142 -------------------LEEKPKMSLWKALLL---------------------------------LVLGLALLVVGAR 169

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532296 442 LMVWWANTIGETFVIPTEIIGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDVCVGLPIPWLlyflieyikh 521
Cdd:COG0530  170 LLVDGAVEIARALGVSELVIGLTIVAIGTSLPELATSIVAARKGEDDLAVGNIIGSNIFNILLVLGIGAL---------- 239

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 115532296 522 pnepLSPISVSSKGLlcSVGMLF-IMLIVLVFAIFLSGWKMNKIFGILMIVSYVFFCVF 579
Cdd:COG0530  240 ----ITPIPVDPAVL--SFDLPVmLAATLLLLGLLRTGGRIGRWEGLLLLALYLAYLAL 292
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 424-581 8.39e-27

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 106.15  E-value: 8.39e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532296  424 LYPATFIISILWIAFFSYLMVWWANTIGETFVIPTEIIGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDVC 503
Cdd:pfam01699   1 LSLLLFILGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAALRGEPDLALGNVIGSNIFNIL 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 115532296  504 VGLPIPWLlyFLIEYIKHPNEPLspisvsSKGLLCSVGMLFIMLIVLVFAIFLsgWKMNKIFGILMIVSYVFFCVFSV 581
Cdd:pfam01699  81 LVLGLSAL--IGPVKVDSLLLKL------DLGVLLLVALLLLLLLLLLLLPLF--GRLSRFEGLVLLLLYIVYLVFQI 148
PLN03151 PLN03151
cation/calcium exchanger; Provisional
 100-582 1.05e-14

cation/calcium exchanger; Provisional


Pssm-ID: 215604 [Multi-domain]  Cd Length: 650  Bit Score: 77.11  E-value: 1.05e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532296 100 GFVVLHMCgLIYMFVSLAIVCDEFFVPSLDVLTEKLSLSDDVAGATFMAAGGSAPEFFTSvIGVFIAQN--NVGIGTIVG 177
Cdd:PLN03151 139 GYAVLGVW-LVALFYLLGNTAADYFCCSLEKLSKLLRLPPTVAGVTLLPLGNGAPDVFAS-IAAFVGKDagEVGLNSVLG 216

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532296 178 SATFnILCVLA----FCTLFSKSILDLTWWplFRDVSIYMLALAMLVFFFMDEMITFPEALAMFSIYIVYCTVMKFNgql 253
Cdd:PLN03151 217 GAVF-VTCVVVgivsLCVADKEVQIDKRCF--IRDLCFFLFTLVSLLVILMVGKVTVGGAIAFVSIYVVYAFLVAAN--- 290

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532296 254 EQLVKkgsdseeasahETQKLAADVphnnnnndlaqlegselrrrssarrqSVPILH-SGTMFRNGIMQLMNQTLEQLPE 332
Cdd:PLN03151 291 EILRK-----------HARRLKLDV--------------------------VTPLLPvQGSIFSPSVEEDESMYSPLLES 333

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532296 333 DSEED----DSSRSR----SNVNIESHDMHRLNVNQS------------MPDRRSSQIEEIKSLLEEQEEKPLDMTWP-- 390
Cdd:PLN03151 334 DTESDvprlQTSLPQwmwaSNVAIYSNHFAKGSVHDEerppwgwtdegaEVESSLFSCSKLFSLLEMPLTIPRRLTIPiv 413

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532296 391 --ETWVKrlTY----VLLAPVVIP-MWVTIPDVR-KSHN----------------------------RGLYP---ATFII 431
Cdd:PLN03151 414 eeDRWSK--TYavasASLAPVLLAfLWSSQDDVSlQARIaayfigvaigstlgflaykytepdrpprRFLIPwvlGGFIM 491

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532296 432 SILWIAFFSYLMVWWANTIGETFVIPTEIIGLTILAAGTSIPDLITSVIVARKGlGD---MAVSSSVGSNIFDVCVGLPI 508
Cdd:PLN03151 492 SIVWFYMIANELVALLVAFGVIFGINPSILGLTVLAWGNSMGDLMSNVALAMNG-GDgvqIAMSGCYAGPMFNTLVGLGM 570

                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 115532296 509 PWLLYfliEYIKHPNEPLSPisvSSKGLLCSVGMLFIMLIVLVFAIFLSGWKMNKIFGILMIVSYVFFCVFSVS 582
Cdd:PLN03151 571 SMLLG---AWSKSPESYMLP---EDSSLFYTMGFLVSGLIWALVVLPRNDMRPNKTLGVGLIALYLIFLTFRVS 638
 
Name Accession Description Interval E-value
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 48-594 3.78e-167

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 504.91  E-value: 3.78e-167
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532296    48 IITPENTPVNASKPFWKTLL----PTCNRSLAPPA-PDVNDDGQFPPDPFSLEQRQNGFVVLHMCGLIYMFVSLAIVCDE 122
Cdd:TIGR00927  398 VVKPAPAVPTTPSPSLTTALfpeaPSPSPSALPPGqPDLHPKAEYPPDLFSVEERRQGWVVLHIFGMMYVFVALAIVCDE 477

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532296   123 FFVPSLDVLTEKLSLSDDVAGATFMAAGGSAPEFFTSVIGVFIAQNNVGIGTIVGSATFNILCVLAFCTLFSKSILDLTW 202
Cdd:TIGR00927  478 YFVPALGVITDKLQISEDVAGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNILFVIGTCALFSREILNLTW 557

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532296   203 WPLFRDVSIYMLALAMLVFFFMDEMITFPEALAMFSIYIVYCTVMKFNGQLEQLVKK----------------------- 259
Cdd:TIGR00927  558 WPLFRDVSFYILDLMMLILFFLDSLIAWWESLLLLLAYALYVFTMKWNKQIELWVKEqlsrrpvakvmalgdlskgdvae 637

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532296   260 --------------------------GSDSEEASAHETQ---KLAADVPHNNNNNDLAQLEGSELRRRSSARRQSVPILH 310
Cdd:TIGR00927  638 aehtgertgeegerpteaegengeesGGEAEQEGETETKgenESEGEIPAERKGEQEGEGEIEAKEADHKGETEAEEVEH 717

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532296   311 SG----------------------------------TMFRNGIMQLMNQTLEQLPEDSEEDDSSRSRSNVNIE------- 349
Cdd:TIGR00927  718 EGeteaegtedegeietgeegeevedegegeaegkhEVETEGDRKETEHEGETEAEGKEDEDEGEIQAGEDGEmkgdega 797

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532296   350 ------------------------------------SHDMHRLNVNQSMPDRR-------------------------SS 368
Cdd:TIGR00927  798 egkvehegeteagekdehegqsetqaddtevkdetgEQELNAENQGEAKQDEKgvdggggsdggdseeeeeeeeeeeeEE 877

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532296   369 QIEEIKSLLEEQEEKPLDMTWPETWVKRLTYVLLAPVVIPMWVTIPDVRKSHNRGLYPATFIISILWIAFFSYLMVWWAN 448
Cdd:TIGR00927  878 EEEEEEEEEEEENEEPLSLEWPETRQKQAIYLFLLPIVFPLWLTVPDVRRQEARKFFVITFLGSIMWIAMFSYLMVWWAH 957

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532296   449 TIGETFVIPTEIIGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDVCVGLPIPWLLYFLIeyikhpnEPLSP 528
Cdd:TIGR00927  958 QVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPVPWLLFSLI-------NGLQP 1030

                          650       660       670       680       690       700
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 115532296   529 ISVSSKGLLCSVGMLFIMLIVLVFAIFLSGWKMNKIFGILMIVSYVFFCVFSVSLETDKLVCPLNI 594
Cdd:TIGR00927 1031 VPVSSNGLFCAIVLLFLMLLFVISSIASCKWRMNKILGFTMFLLYFVFLIISVMLEDRIISCPVSV 1096
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
 104-576 8.26e-56

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 191.00  E-value: 8.26e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532296  104 LHMCGLIYMFVSLAIVCDEFFVPSLDVLTEKLSLSDDVAGATFMAAGGSAPEFFTSVIGVFIAQNNVGIGTIVGSATFNI 183
Cdd:TIGR00367   1 LLLIGYLILGLILLIYGADLFVKSSVRIARHLGISPLIIGVTVVAIGTSLPELFTSLIASLMGQPDIGVGNVIGSNIFNI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532296  184 LCVLAFCTLFSKsILDLTWWpLFRDVSIYMLALAMLVFFFMDEMITFPEALAMFSIYIVYctvMKFNGQLEQLVKKGSDS 263
Cdd:TIGR00367  81 LLILGLSAIFSP-IIVDKDW-LRRDILFYLLVSILLLFFGLDGQISRIDGVVLLILYIVY---LLFLVKNERWVKYDTYT 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532296  264 EEasahetqklaadvpHNNNNNDlaqlegselrrrssarrqsvpilhsgtmfRNGIMQLMnqtleqlpedseeddssrsr 343
Cdd:TIGR00367 156 EE--------------NLDENNR-----------------------------RPQIFFSL-------------------- 172

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532296  344 snvnieshdmhrlnvnqsmpdrrssqieeikslleeqeekpldmtwpetwvkrltyvllapvvipmwvtipdvrkshnrg 423
Cdd:TIGR00367     --------------------------------------------------------------------------------

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532296  424 lypATFIISILWIAFFSYLMVWWANTIGETFVIPTEIIGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDVC 503
Cdd:TIGR00367 173 ---VLLIIGLIGLVVGSRLLVDGAVKIAEILGISEKIIGLTLLAIGTSLPELVVSLAAARKGLGDIAVGNVIGSNIFNIL 249

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 115532296  504 VGLPIPWLLYFLieyikhpnePLSPISVSSKGLLCSVGMLFIMLivlvfaIFLSGWKMNKIFGILMIVSYVFF 576
Cdd:TIGR00367 250 VGLGVPSLFMPI---------PVEPLAYNLDAPVMVIVTLLLML------FFKTSMKLGRWEGILLLALYIAY 307
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
122-579 5.78e-38

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 141.81  E-value: 5.78e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532296 122 EFFVPSLDVLTEKLSLSDDVAGATFMAAGGSAPEFFTSVIGVFIAQNNVGIGTIVGSATFNILCVLAFCTLFSKSILDLT 201
Cdd:COG0530    2 DLLVRGADALARRLGISPLVIGLTIVAFGTSLPELAVSVTAALDGSPDIAVGNVVGSNIANILLILGLAALIRPLAVDRR 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532296 202 WwpLFRDVSIYMLALAMLVFFFMDEMITFPEALAMFSIYIVYctvmkfngqleqlvkkgsdseeasahetqklaadvphn 281
Cdd:COG0530   82 V--LRRDLPFLLLASLLLLALLLDGTLSRIDGVILLLLYVLY-------------------------------------- 121

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532296 282 nnnndlaqlegselrrrssarrqsvpilhsgtmfrngIMQLMNQTLEQLPEDSEEDDssrsrsnvnieshdmhrlnvnqs 361
Cdd:COG0530  122 -------------------------------------LYYLIRRARKEPAWEEVEEE----------------------- 141

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532296 362 mpdrrssqieeikslleeqEEKPLDMTWPETWVKrltyvllapvvipmwvtipdvrkshnrglypatFIISILWIAFFSY 441
Cdd:COG0530  142 -------------------LEEKPKMSLWKALLL---------------------------------LVLGLALLVVGAR 169

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532296 442 LMVWWANTIGETFVIPTEIIGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDVCVGLPIPWLlyflieyikh 521
Cdd:COG0530  170 LLVDGAVEIARALGVSELVIGLTIVAIGTSLPELATSIVAARKGEDDLAVGNIIGSNIFNILLVLGIGAL---------- 239

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 115532296 522 pnepLSPISVSSKGLlcSVGMLF-IMLIVLVFAIFLSGWKMNKIFGILMIVSYVFFCVF 579
Cdd:COG0530  240 ----ITPIPVDPAVL--SFDLPVmLAATLLLLGLLRTGGRIGRWEGLLLLALYLAYLAL 292
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 424-581 8.39e-27

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 106.15  E-value: 8.39e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532296  424 LYPATFIISILWIAFFSYLMVWWANTIGETFVIPTEIIGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDVC 503
Cdd:pfam01699   1 LSLLLFILGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAALRGEPDLALGNVIGSNIFNIL 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 115532296  504 VGLPIPWLlyFLIEYIKHPNEPLspisvsSKGLLCSVGMLFIMLIVLVFAIFLsgWKMNKIFGILMIVSYVFFCVFSV 581
Cdd:pfam01699  81 LVLGLSAL--IGPVKVDSLLLKL------DLGVLLLVALLLLLLLLLLLLPLF--GRLSRFEGLVLLLLYIVYLVFQI 148
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 108-249 2.80e-25

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 101.91  E-value: 2.80e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532296  108 GLIYMFVSLAIVCDEFFVPSLDVLTEKLSLSDDVAGATFMAAGGSAPEFFTSVIGVFIAQNNVGIGTIVGSATFNILCVL 187
Cdd:pfam01699   4 LLFILGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAALRGEPDLALGNVIGSNIFNILLVL 83

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 115532296  188 AFCTLFSKSILDLTW----WPLFRDVSIYMLALAMLVFFFMDEMITFPEALAMFSIYIVYCTVMKF 249
Cdd:pfam01699  84 GLSALIGPVKVDSLLlkldLGVLLLVALLLLLLLLLLLLPLFGRLSRFEGLVLLLLYIVYLVFQIV 149
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
450-581 2.13e-16

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 79.79  E-value: 2.13e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532296 450 IGETFVIPTEIIGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDVCVGLPIPWLlyflieyikhpnepLSPI 529
Cdd:COG0530   11 LARRLGISPLVIGLTIVAFGTSLPELAVSVTAALDGSPDIAVGNVVGSNIANILLILGLAAL--------------IRPL 76

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 115532296 530 SVSSKGLlcSVGMLFIMLIVLVFAIFLSGWKMNKIFGILMIVSYVFFCVFSV 581
Cdd:COG0530   77 AVDRRVL--RRDLPFLLLASLLLLALLLDGTLSRIDGVILLLLYVLYLYYLI 126
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
109-247 8.09e-16

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 78.25  E-value: 8.09e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532296 109 LIYMFVSLA--IVCDEFFVPSLDVLTEKLSLSDDVAGATFMAAGGSAPEFFTSVIGVFIAQNNVGIGTIVGSATFNILCV 186
Cdd:COG0530  154 LLLLVLGLAllVVGARLLVDGAVEIARALGVSELVIGLTIVAIGTSLPELATSIVAARKGEDDLAVGNIIGSNIFNILLV 233

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 115532296 187 LAFCTLFsksildlTWWPLFRDVSIY------MLALAMLVFFFMDEMITFPEALAMFSIYIVYCTVM 247
Cdd:COG0530  234 LGIGALI-------TPIPVDPAVLSFdlpvmlAATLLLLGLLRTGGRIGRWEGLLLLALYLAYLALL 293
PLN03151 PLN03151
cation/calcium exchanger; Provisional
 100-582 1.05e-14

cation/calcium exchanger; Provisional


Pssm-ID: 215604 [Multi-domain]  Cd Length: 650  Bit Score: 77.11  E-value: 1.05e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532296 100 GFVVLHMCgLIYMFVSLAIVCDEFFVPSLDVLTEKLSLSDDVAGATFMAAGGSAPEFFTSvIGVFIAQN--NVGIGTIVG 177
Cdd:PLN03151 139 GYAVLGVW-LVALFYLLGNTAADYFCCSLEKLSKLLRLPPTVAGVTLLPLGNGAPDVFAS-IAAFVGKDagEVGLNSVLG 216

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532296 178 SATFnILCVLA----FCTLFSKSILDLTWWplFRDVSIYMLALAMLVFFFMDEMITFPEALAMFSIYIVYCTVMKFNgql 253
Cdd:PLN03151 217 GAVF-VTCVVVgivsLCVADKEVQIDKRCF--IRDLCFFLFTLVSLLVILMVGKVTVGGAIAFVSIYVVYAFLVAAN--- 290

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532296 254 EQLVKkgsdseeasahETQKLAADVphnnnnndlaqlegselrrrssarrqSVPILH-SGTMFRNGIMQLMNQTLEQLPE 332
Cdd:PLN03151 291 EILRK-----------HARRLKLDV--------------------------VTPLLPvQGSIFSPSVEEDESMYSPLLES 333

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532296 333 DSEED----DSSRSR----SNVNIESHDMHRLNVNQS------------MPDRRSSQIEEIKSLLEEQEEKPLDMTWP-- 390
Cdd:PLN03151 334 DTESDvprlQTSLPQwmwaSNVAIYSNHFAKGSVHDEerppwgwtdegaEVESSLFSCSKLFSLLEMPLTIPRRLTIPiv 413

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532296 391 --ETWVKrlTY----VLLAPVVIP-MWVTIPDVR-KSHN----------------------------RGLYP---ATFII 431
Cdd:PLN03151 414 eeDRWSK--TYavasASLAPVLLAfLWSSQDDVSlQARIaayfigvaigstlgflaykytepdrpprRFLIPwvlGGFIM 491

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532296 432 SILWIAFFSYLMVWWANTIGETFVIPTEIIGLTILAAGTSIPDLITSVIVARKGlGD---MAVSSSVGSNIFDVCVGLPI 508
Cdd:PLN03151 492 SIVWFYMIANELVALLVAFGVIFGINPSILGLTVLAWGNSMGDLMSNVALAMNG-GDgvqIAMSGCYAGPMFNTLVGLGM 570

                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 115532296 509 PWLLYfliEYIKHPNEPLSPisvSSKGLLCSVGMLFIMLIVLVFAIFLSGWKMNKIFGILMIVSYVFFCVFSVS 582
Cdd:PLN03151 571 SMLLG---AWSKSPESYMLP---EDSSLFYTMGFLVSGLIWALVVLPRNDMRPNKTLGVGLIALYLIFLTFRVS 638
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
 429-584 5.08e-12

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 66.96  E-value: 5.08e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532296  429 FIISILWIAFFSYLMVWWANTIGETFVIPTEIIGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDVCVGLPI 508
Cdd:TIGR00367   7 LILGLILLIYGADLFVKSSVRIARHLGISPLIIGVTVVAIGTSLPELFTSLIASLMGQPDIGVGNVIGSNIFNILLILGL 86

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 115532296  509 PWLlyflieyikhpnepLSPISVSSKGLLCSVGMLFIMLIVLVFAIFLSGWkmNKIFGILMIVSYVFFCVFSVSLE 584
Cdd:TIGR00367  87 SAI--------------FSPIIVDKDWLRRDILFYLLVSILLLFFGLDGQI--SRIDGVVLLILYIVYLLFLVKNE 146
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 447-512 9.91e-11

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 63.51  E-value: 9.91e-11
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 115532296 447 ANTIGETFVIPTEIIGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDVCVGLPIPWLL 512
Cdd:PRK10734 197 ATVLANYFAISELTIGLTVIAIGTSLPELATAIAGARKGENDIAVGNIIGSNIFNIVIVLGLPALI 262
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 102-190 3.11e-10

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 63.27  E-value: 3.11e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532296  102 VVLHMCGLIYMFVSLAIVCDEFfVPSLDVLTEKLS------------------LSDDVAGATFMAAGGSAPEFFTSVIGV 163
Cdd:TIGR00845  75 ATVYFVAMVYMFLGVSIIADRF-MASIEVITSQEKeitikkpngettvttvriWNETVSNLTLMALGSSAPEILLSVIEV 153

                          90       100       110
                  ....*....|....*....|....*....|.
gi 115532296  164 fIAQN----NVGIGTIVGSATFNILCVLAFC 190
Cdd:TIGR00845 154 -CGHNfeagDLGPSTIVGSAAFNMFIIIAIC 183
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 427-583 1.03e-09

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 60.04  E-value: 1.03e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532296 427 ATFIISILWIAFFSYLMVWWANTIGETFVIPTEIIGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDVCVGL 506
Cdd:PRK10734   6 ALLIIGLLLLVYGADRLVFAASILCRTFGIPPLIIGMTVVGIGTSLPEIIVSVAASLHGQRDLAVGTALGSNITNILLIL 85

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 115532296 507 PIPWLLYflieyikhpneplsPISVSSKGLLCSvgmLFIMLIVLVFA-IFLSGWKMNKIFGILMIVSYVFFCVFSVSL 583
Cdd:PRK10734  86 GLAALIR--------------PFTVHSDVLRRE---LPLMLLVSVLAgSVLYDGQLSRSDGIFLLLLAVLWLLFIVKI 146
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
 81-243 1.52e-08

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 56.56  E-value: 1.52e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532296   81 VNDDGQFPPDPFSLeqrqngfvVLHMCGLIYMFVSLAIvcdefFVPSLDVLTEKLSLSDDVAGATFMAAGGSAPEFFTSV 160
Cdd:TIGR00367 159 LDENNRRPQIFFSL--------VLLIIGLIGLVVGSRL-----LVDGAVKIAEILGISEKIIGLTLLAIGTSLPELVVSL 225

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532296  161 IGVFIAQNNVGIGTIVGSATFNILCVLAFCTLFSKSILDLTwwPLFRDVSIYML-ALAMLVFFFMDEMITFPEALAMFSI 239
Cdd:TIGR00367 226 AAARKGLGDIAVGNVIGSNIFNILVGLGVPSLFMPIPVEPL--AYNLDAPVMVIvTLLLMLFFKTSMKLGRWEGILLLAL 303


                  ....
gi 115532296  240 YIVY 243
Cdd:TIGR00367 304 YIAY 307
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 108-222 5.11e-06

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 48.87  E-value: 5.11e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532296 108 GLIYMFVSLAIVCDeffvpSLDVLTEKLSLSDDVAGATFMAAGGSAPEFFTSVIGVFIAQNNVGIGTIVGSATFNILCVL 187
Cdd:PRK10734 182 ALIIMPMATRMVID-----NATVLANYFAISELTIGLTVIAIGTSLPELATAIAGARKGENDIAVGNIIGSNIFNIVIVL 256

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 115532296 188 AFCTLFSKSILDLTWWPlfRDVSIYMLALAMLVFF 222
Cdd:PRK10734 257 GLPALISPGEINPLAFS--RDYWVMLLVSVIFALL 289
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 427-577 1.16e-04

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 45.17  E-value: 1.16e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532296  427 ATFIISILWIAFFSYLMVWWANTIGETFVIPTEIIGLTILAAGTSIPDLITSVIVARKGLG-DMAVSSSVGSNIFDVCVG 505
Cdd:TIGR00845 757 ACFVVSILMIGVLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQYaDASIGNVTGSNAVNVFLG 836

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532296  506 LPIPWllyfLIEYIKHPNEPlSPISVSSKGLLCSVGML----FIMLIVLVF---------------AIFLSGWkmnkIFG 566
Cdd:TIGR00845 837 IGVAW----SIAAIYHAANG-TQFKVSPGTLAFSVTLFtifaFICIGVLLYrrrpeiggelggprtAKLLTSA----LFV 907

                         170
                  ....*....|.
gi 115532296  567 ILMiVSYVFFC 577
Cdd:TIGR00845 908 LLW-LLYILFS 917
caca2 TIGR00846
calcium/proton exchanger; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the ...
 118-244 4.49e-04

calcium/proton exchanger; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is generated from the calcium ion/proton exchangers of the CacA family. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273297 [Multi-domain]  Cd Length: 363  Bit Score: 42.83  E-value: 4.49e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532296  118 IVCDEFFVPSLDVLTEKLSLSDDVAGATFMAAGGSAPEFFTSVIGVFIAQNNVGIGTIVGSATFNILCVLAFCTLFSKSI 197
Cdd:TIGR00846 232 ILLADYLVDTIDDAVDSWGLSVAFIGLILAPIVGNAAEHVTAVKAALKNKLDLALGVALGSALQIILFVVPLVVLVAWML 311

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 115532296  198 ---LDLTWWPLfrDVSIYMLALAMLVFFFMDEMITFPEALAMFSIYIVYC 244
Cdd:TIGR00846 312 gipMDLNFGTF--ETIVLALSLFLTTITLQDGRSNYLEGAVLLALYIIIA 359
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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