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Conserved domains on  [gi|114050785|ref|NP_001039467|]
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CD48 antigen precursor [Bos taurus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IgV_CD2_like_N cd05775
N-terminal immunoglobulin (Ig)-like domain of T-cell surface antigen CD2, and similar domains; ...
 27-125 7.84e-36

N-terminal immunoglobulin (Ig)-like domain of T-cell surface antigen CD2, and similar domains; The members here are composed of the N-terminal immunoglobulin (Ig)-like domain (or domain 1) of T-cell surface antigen Clusters of Differentiation (CD) 2 and similar proteins. CD2 is a T-cell specific surface glycoprotein and is critically important for mediating adhesion between T cells and antigen-presenting cells or between cytolytic T cells and target cells. CD2 is located on chromosome 1 at 1p13 in humans and on chromosome 3 in mice. CD2 contains an extracellular domain with two or Ig-like domains, a single transmembrane segment, and a cytoplasmic region rich in proline and basic residues.


:

Pssm-ID: 409431  Cd Length: 98  Bit Score: 122.46  E-value: 7.84e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114050785  27 QGHSKYAIPGDNVTLHISNLPKNHKSLTWFYTTDqKIVEWEF-DEPMYFNTkFKNRATLHPQSGALFIRNIQKEDSSTYL 105
Cdd:cd05775    1 SSGEVYGALGGNVTLTISSLQDDIDEIKWKKTKD-KIVEWENnIGPTYFGS-FKDRVLLDKESGSLTIKNLTKEDSGTYE 78

                         90       100
                 ....*....|....*....|
gi 114050785 106 LRVLKDNGDEKEWKISLMVL 125
Cdd:cd05775   79 LEITSTNGKVLSSKFTLEVL 98
Ig super family cl11960
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 130-207 5.03e-03

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


The actual alignment was detected with superfamily member cd00098:

Pssm-ID: 472250  Cd Length: 95  Bit Score: 35.51  E-value: 5.03e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114050785 130 KPVITVKKLWEMNNCKLMLSCVIQD---QSVNYTWY--------WESGSFPKQLQG------SVLQVVHTPENYSKSYTC 192
Cdd:cd00098    1 TVTLLPPSPEEKGGGKVTLVCLVSGfypKDITVTWLkngvpltsGVSTSSPVEPNDgtysvtSSLTVPPSDWDEGATYTC 80

                         90
                 ....*....|....*
gi 114050785 193 QVSNPVSSQNSTINF 207
Cdd:cd00098   81 VVTHESLKSPLSKTW 95
 
Name Accession Description Interval E-value
IgV_CD2_like_N cd05775
N-terminal immunoglobulin (Ig)-like domain of T-cell surface antigen CD2, and similar domains; ...
 27-125 7.84e-36

N-terminal immunoglobulin (Ig)-like domain of T-cell surface antigen CD2, and similar domains; The members here are composed of the N-terminal immunoglobulin (Ig)-like domain (or domain 1) of T-cell surface antigen Clusters of Differentiation (CD) 2 and similar proteins. CD2 is a T-cell specific surface glycoprotein and is critically important for mediating adhesion between T cells and antigen-presenting cells or between cytolytic T cells and target cells. CD2 is located on chromosome 1 at 1p13 in humans and on chromosome 3 in mice. CD2 contains an extracellular domain with two or Ig-like domains, a single transmembrane segment, and a cytoplasmic region rich in proline and basic residues.


Pssm-ID: 409431  Cd Length: 98  Bit Score: 122.46  E-value: 7.84e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114050785  27 QGHSKYAIPGDNVTLHISNLPKNHKSLTWFYTTDqKIVEWEF-DEPMYFNTkFKNRATLHPQSGALFIRNIQKEDSSTYL 105
Cdd:cd05775    1 SSGEVYGALGGNVTLTISSLQDDIDEIKWKKTKD-KIVEWENnIGPTYFGS-FKDRVLLDKESGSLTIKNLTKEDSGTYE 78

                         90       100
                 ....*....|....*....|
gi 114050785 106 LRVLKDNGDEKEWKISLMVL 125
Cdd:cd05775   79 LEITSTNGKVLSSKFTLEVL 98
Receptor_2B4 pfam11465
Natural killer cell receptor 2B4; 2B4 is a transmembrane receptor which is expressed primarily ...
 33-126 1.29e-04

Natural killer cell receptor 2B4; 2B4 is a transmembrane receptor which is expressed primarily on natural killer cells. It plays a role in activating NK-mediated cytotoxicity through its interaction with CD48 on target cells in a subset of CD8 T cells. The structure of 2B4 consists of an immunoglobulin variable domain fold and contains two beta-sheets. One of the beta-sheets, the six-stranded sheet, contains structural features that may have a role in ligand recognition and receptor function.


Pssm-ID: 288342  Cd Length: 108  Bit Score: 40.33  E-value: 1.29e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114050785   33 AIPGDNVTLHISNLPKNHKSLTWFYTTD-----QKIVEWEFDEPMYFNTKFKNRATLHPQSGALFIRNIQKEDSSTYLLR 107
Cdd:pfam11465  10 GVSGKPVQLRPSNIQTKVVSIAWKKLLPshngfHHILKWENGSLPSNNMCSSDIYGFIVKNFALSIKSAKLQDSGHYLLE 89

                          90
                  ....*....|....*....
gi 114050785  108 VLKDNGDEKEWKISLMVLD 126
Cdd:pfam11465  90 ITNISGKVCTKNFQVLIFD 108
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 30-116 3.93e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 35.56  E-value: 3.93e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114050785    30 SKYAIPGDNVTLHISNLPKNHKSLTWFYTTDQKIvewefdepmyfntKFKNRATLHPQSGA--LFIRNIQKEDSSTYLLR 107
Cdd:smart00410   3 SVTVKEGESVTLSCEASGSPPPEVTWYKQGGKLL-------------AESGRFSVSRSGSTstLTISNVTPEDSGTYTCA 69


                   ....*....
gi 114050785   108 VLKDNGDEK 116
Cdd:smart00410  70 ATNSSGSAS 78
IgC1 cd00098
Immunoglobulin Constant-1 (C1)-set domain; The members here are composed of C1-set domains, ...
 130-207 5.03e-03

Immunoglobulin Constant-1 (C1)-set domain; The members here are composed of C1-set domains, classical Ig-like domains resembling the antibody constant domain. Members of the IgC1 family are components of immunoglobulin, T-cell receptors, CD1 cell surface glycoproteins, secretory glycoproteins A/C, and major histocompatibility complex (MHC) class I/II molecules. In immunoglobulins, each chain is composed of one variable domain (IgV) and one or more IgC domains. These names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. The IgV domain is responsible for antigen binding, while the IgC domain is involved in oligomerization and molecular interactions. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other strands by G, F, C, and C'.


Pssm-ID: 409354  Cd Length: 95  Bit Score: 35.51  E-value: 5.03e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114050785 130 KPVITVKKLWEMNNCKLMLSCVIQD---QSVNYTWY--------WESGSFPKQLQG------SVLQVVHTPENYSKSYTC 192
Cdd:cd00098    1 TVTLLPPSPEEKGGGKVTLVCLVSGfypKDITVTWLkngvpltsGVSTSSPVEPNDgtysvtSSLTVPPSDWDEGATYTC 80

                         90
                 ....*....|....*
gi 114050785 193 QVSNPVSSQNSTINF 207
Cdd:cd00098   81 VVTHESLKSPLSKTW 95
 
Name Accession Description Interval E-value
IgV_CD2_like_N cd05775
N-terminal immunoglobulin (Ig)-like domain of T-cell surface antigen CD2, and similar domains; ...
 27-125 7.84e-36

N-terminal immunoglobulin (Ig)-like domain of T-cell surface antigen CD2, and similar domains; The members here are composed of the N-terminal immunoglobulin (Ig)-like domain (or domain 1) of T-cell surface antigen Clusters of Differentiation (CD) 2 and similar proteins. CD2 is a T-cell specific surface glycoprotein and is critically important for mediating adhesion between T cells and antigen-presenting cells or between cytolytic T cells and target cells. CD2 is located on chromosome 1 at 1p13 in humans and on chromosome 3 in mice. CD2 contains an extracellular domain with two or Ig-like domains, a single transmembrane segment, and a cytoplasmic region rich in proline and basic residues.


Pssm-ID: 409431  Cd Length: 98  Bit Score: 122.46  E-value: 7.84e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114050785  27 QGHSKYAIPGDNVTLHISNLPKNHKSLTWFYTTDqKIVEWEF-DEPMYFNTkFKNRATLHPQSGALFIRNIQKEDSSTYL 105
Cdd:cd05775    1 SSGEVYGALGGNVTLTISSLQDDIDEIKWKKTKD-KIVEWENnIGPTYFGS-FKDRVLLDKESGSLTIKNLTKEDSGTYE 78

                         90       100
                 ....*....|....*....|
gi 114050785 106 LRVLKDNGDEKEWKISLMVL 125
Cdd:cd05775   79 LEITSTNGKVLSSKFTLEVL 98
IgV_CEACAM_like cd05741
Immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion ...
 32-124 3.46e-10

Immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM) and related domains. The CEA family is a group of anchored or secreted glycoproteins, expressed by epithelial cells, leukocytes, endothelial cells and placenta. The CEA family is divided into the CEACAM and pregnancy-specific glycoprotein (PSG) subfamilies. This group represents the CEACAM subfamily. CEACAM1 has many important cellular functions: it is a cell adhesion molecule and a signaling molecule that regulates the growth of tumor cells, an angiogenic factor, and a receptor for bacterial and viral pathogens, including mouse hepatitis virus (MHV). In mice, four isoforms of CEACAM1 generated by alternative splicing have either two (D1, D4) or four (D1-D4) Ig-like domains on the cell surface. This family corresponds to the D1 Ig-like domain. Also belonging to this group is the N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family, CD84-like family. The SLAM family is a group of immune-cell specific receptors that can regulate both adaptive and innate immune responses. SLAM family proteins are organized as an extracellular domain with having two or four Ig-like domains, a single transmembrane segment, and a cytoplasmic region having Tyr-based motifs. The extracellular domain is organized as a membrane-distal Ig variable (IgV) domain that is responsible for ligand recognition and a membrane-proximal truncated Ig constant-2 (IgC2) domain.


Pssm-ID: 409403  Cd Length: 102  Bit Score: 55.60  E-value: 3.46e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114050785  32 YAIPGDNVTLHISNLPKNHKSLTWFYT----TDQKIVEWE--FDEPMYFNtKFKNRATLHPqSGALFIRNIQKEDSSTYL 105
Cdd:cd05741    6 YGAEGKNVLLLVPNLQTPLKSVSWYKGkqvsRNDEIAEYEnsSDEFRAGS-AFSGREYIYT-NGSLLIQNITLSDTGFYT 83

                         90
                 ....*....|....*....
gi 114050785 106 LRVLKDNGDEKEWKISLMV 124
Cdd:cd05741   84 LESTNIGGKTESATFQLHV 102
IgV_CEACAM_D1 cd05774
First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion ...
 36-113 3.67e-08

First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM); The members here are composed of the immunoglobulin (Ig)-like domain 1 in carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM) proteins. The CEA family is a group of anchored or secreted glycoproteins, expressed by epithelial cells, leukocytes, endothelial cells, and placenta. The CEA family is divided into the CEACAM and pregnancy-specific glycoprotein (PSG) subfamilies. This group represents the CEACAM subfamily. CEACAM1 has many important cellular functions: it is a cell adhesion molecule and a signaling molecule that regulates the growth of tumor cells, an angiogenic factor, and a receptor for bacterial and viral pathogens, including mouse hepatitis virus (MHV). In mice, four isoforms of CEACAM1 generated by alternative splicing have either two (D1, D4) or four (D1-D4) Ig-like domains on the cell surface.


Pssm-ID: 409430  Cd Length: 105  Bit Score: 49.96  E-value: 3.67e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114050785  36 GDNVTLHISNLPKNHKSLTWF----YTTDQKIVEWEFD------EPMYFntkfkNRATLHPqSGALFIRNIQKEDSSTYL 105
Cdd:cd05774   13 GENVLLLVHNLPENLLAYAWYkgktVSPNFLIASYIIStnsstpGPAYS-----GRETIYP-NGSLLIQNVTQKDTGFYT 86


                 ....*...
gi 114050785 106 LRVLKDNG 113
Cdd:cd05774   87 LQTITADL 94
Receptor_2B4 pfam11465
Natural killer cell receptor 2B4; 2B4 is a transmembrane receptor which is expressed primarily ...
 33-126 1.29e-04

Natural killer cell receptor 2B4; 2B4 is a transmembrane receptor which is expressed primarily on natural killer cells. It plays a role in activating NK-mediated cytotoxicity through its interaction with CD48 on target cells in a subset of CD8 T cells. The structure of 2B4 consists of an immunoglobulin variable domain fold and contains two beta-sheets. One of the beta-sheets, the six-stranded sheet, contains structural features that may have a role in ligand recognition and receptor function.


Pssm-ID: 288342  Cd Length: 108  Bit Score: 40.33  E-value: 1.29e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114050785   33 AIPGDNVTLHISNLPKNHKSLTWFYTTD-----QKIVEWEFDEPMYFNTKFKNRATLHPQSGALFIRNIQKEDSSTYLLR 107
Cdd:pfam11465  10 GVSGKPVQLRPSNIQTKVVSIAWKKLLPshngfHHILKWENGSLPSNNMCSSDIYGFIVKNFALSIKSAKLQDSGHYLLE 89

                          90
                  ....*....|....*....
gi 114050785  108 VLKDNGDEKEWKISLMVLD 126
Cdd:pfam11465  90 ITNISGKVCTKNFQVLIFD 108
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 30-116 3.93e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 35.56  E-value: 3.93e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114050785    30 SKYAIPGDNVTLHISNLPKNHKSLTWFYTTDQKIvewefdepmyfntKFKNRATLHPQSGA--LFIRNIQKEDSSTYLLR 107
Cdd:smart00410   3 SVTVKEGESVTLSCEASGSPPPEVTWYKQGGKLL-------------AESGRFSVSRSGSTstLTISNVTPEDSGTYTCA 69


                   ....*....
gi 114050785   108 VLKDNGDEK 116
Cdd:smart00410  70 ATNSSGSAS 78
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 36-125 4.51e-03

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 35.90  E-value: 4.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114050785   36 GDNVTLHISNLP---KNHKSLTWFYTTDQKIVEWEFDE--PMYFNTKFKNRATLH----PQSGALFIRNIQKEDSSTYLL 106
Cdd:pfam07686  11 GGSVTLPCTYSSsmsEASTSVYWYRQPPGKGPTFLIAYysNGSEEGVKKGRFSGRgdpsNGDGSLTIQNLTLSDSGTYTC 90

                          90
                  ....*....|....*....
gi 114050785  107 RVLKDNGDEKEWKISLMVL 125
Cdd:pfam07686  91 AVIPSGEGVFGKGTRLTVL 109
IgC1 cd00098
Immunoglobulin Constant-1 (C1)-set domain; The members here are composed of C1-set domains, ...
 130-207 5.03e-03

Immunoglobulin Constant-1 (C1)-set domain; The members here are composed of C1-set domains, classical Ig-like domains resembling the antibody constant domain. Members of the IgC1 family are components of immunoglobulin, T-cell receptors, CD1 cell surface glycoproteins, secretory glycoproteins A/C, and major histocompatibility complex (MHC) class I/II molecules. In immunoglobulins, each chain is composed of one variable domain (IgV) and one or more IgC domains. These names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. The IgV domain is responsible for antigen binding, while the IgC domain is involved in oligomerization and molecular interactions. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other strands by G, F, C, and C'.


Pssm-ID: 409354  Cd Length: 95  Bit Score: 35.51  E-value: 5.03e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114050785 130 KPVITVKKLWEMNNCKLMLSCVIQD---QSVNYTWY--------WESGSFPKQLQG------SVLQVVHTPENYSKSYTC 192
Cdd:cd00098    1 TVTLLPPSPEEKGGGKVTLVCLVSGfypKDITVTWLkngvpltsGVSTSSPVEPNDgtysvtSSLTVPPSDWDEGATYTC 80

                         90
                 ....*....|....*
gi 114050785 193 QVSNPVSSQNSTINF 207
Cdd:cd00098   81 VVTHESLKSPLSKTW 95
Ig_SLAM-like_N cd16842
N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule ...
 32-108 5.45e-03

N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family; The members here are composed of the N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family and similar proteins. The SLAM family is a group of immune-cell specific receptors that can regulate both adaptive and innate immune responses. Members of this group include proteins such as CD84, SLAM (CD150), Ly-9 (CD229), NTB-A (ly-108, SLAM6), 19A (CRACC), and SLAMF9. The genes coding for the SLAM family are nested on chromosome 1, in humans at 1q23, and in mice at 1H2. The SLAM family is a subset of the CD2 family, which also includes CD2 and CD58 located on chromosome 1 at 1p13 in humans. In mice, CD2 is located on chromosome 3, and there is no CD58 homolog. The SLAM family proteins are organized as an extracellular domain with either two or four Ig-like domains, a single transmembrane segment, and a cytoplasmic region having Tyr-based motifs. The extracellular domain is organized as a membrane-distal Ig variable (IgV) domain that is responsible for ligand recognition and a membrane-proximal truncated Ig constant-2 (IgC2) domain.


Pssm-ID: 409517  Cd Length: 102  Bit Score: 35.37  E-value: 5.45e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114050785  32 YAIPGDNVTLHISNLPKNH-KSLTWFYTTDQKIVEWEFDEP---MYFNTKFKNRATLHPQSGALFIRNIQKEDSSTYLLR 107
Cdd:cd16842    4 NGILGGSVTFPLNISDGQEiENITWSFKTSLAVIAPGEGGApeiIITDKSYKERLNISQNDYSLQISNLTMEDAGSYRAR 83


                 .
gi 114050785 108 V 108
Cdd:cd16842   84 I 84
Ig cd00096
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 146-205 9.38e-03

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409353 [Multi-domain]  Cd Length: 70  Bit Score: 34.23  E-value: 9.38e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 114050785 146 LMLSCVIQ-DQSVNYTWYWESGSFPKQLQ--------GSVLQVVHTPENYSKSYTCQVSNPVSSQNSTI 205
Cdd:cd00096    1 VTLTCSASgNPPPTITWYKNGKPLPPSSRdsrrselgNGTLTISNVTLEDSGTYTCVASNSAGGSASAS 69
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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