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Conserved domains on  [gi|113678710|ref|NP_001038424|]
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cyclin-P [Danio rerio]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CYCLIN_CNTD2 cd20542
cyclin box found in Cyclin N-terminal domain-containing protein 2 (CNTD2) and similar proteins; ...
 164-259 2.26e-46

cyclin box found in Cyclin N-terminal domain-containing protein 2 (CNTD2) and similar proteins; CNTD2 is an atypical cyclin upregulated in human cancer tissues. It promotes cell proliferation and migration, as well as increases tumor growth in vivo. It can function as a prognostic factor and drug target. CNTD2 contains one cyclin box. The cyclin box is a protein binding domain.


:

Pssm-ID: 410245 [Multi-domain]  Cd Length: 96  Bit Score: 154.02  E-value: 2.26e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678710 164 RAILVDWLIQVHEVFQFSEETLYLTVHLLNRALRLIKVSISGLQLLGVVCLFLAAKREECLLPEVSELCYLMENAYSKKQ 243
Cdd:cd20542    1 RAILVDWLVQVQEHLELSTQTLHLAVALLDRYLSRQKISLSLLQLLGITCLFIACKFEERFPPEVATLCYLTDDSYSKKQ 80

                         90
                 ....*....|....*.
gi 113678710 244 LLRMERRVLIGLKFDL 259
Cdd:cd20542   81 VLRMERRVLRRLRFDL 96
Cyclin_C pfam02984
Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 264-384 3.90e-15

Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the C-terminal domain.


:

Pssm-ID: 397230  Cd Length: 119  Bit Score: 71.12  E-value: 3.90e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678710  264 PLHFL--LISASIARCSDKVVWMARYLLELSLLEGRCVVYLPAQLAGAALRLARKILQeaaapeaEMAWCIASSIHIG-S 340
Cdd:pfam02984   3 PLSFLrrFSKAADYLHDLELRTLAKYLLELTLLDYDFLKYPPSLIAAAAVYLARKTLN-------SPEWTETLEHYTGyS 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 113678710  341 EAVLLSIMQIMAIAAARAQTRETRATFIKFSTVQTLHVSMHPAL 384
Cdd:pfam02984  76 EEDLKPCVKLLLELLLNAPSSKLQAVRRKYSSSKFMKVSTLPPL 119
 
Name Accession Description Interval E-value
CYCLIN_CNTD2 cd20542
cyclin box found in Cyclin N-terminal domain-containing protein 2 (CNTD2) and similar proteins; ...
 164-259 2.26e-46

cyclin box found in Cyclin N-terminal domain-containing protein 2 (CNTD2) and similar proteins; CNTD2 is an atypical cyclin upregulated in human cancer tissues. It promotes cell proliferation and migration, as well as increases tumor growth in vivo. It can function as a prognostic factor and drug target. CNTD2 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410245 [Multi-domain]  Cd Length: 96  Bit Score: 154.02  E-value: 2.26e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678710 164 RAILVDWLIQVHEVFQFSEETLYLTVHLLNRALRLIKVSISGLQLLGVVCLFLAAKREECLLPEVSELCYLMENAYSKKQ 243
Cdd:cd20542    1 RAILVDWLVQVQEHLELSTQTLHLAVALLDRYLSRQKISLSLLQLLGITCLFIACKFEERFPPEVATLCYLTDDSYSKKQ 80

                         90
                 ....*....|....*.
gi 113678710 244 LLRMERRVLIGLKFDL 259
Cdd:cd20542   81 VLRMERRVLRRLRFDL 96
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 136-259 1.38e-35

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 126.86  E-value: 1.38e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678710  136 DIFsDMMRSQLLCTLPNADLP---KPFTDTTRAILVDWLIQVHEVFQFSEETLYLTVHLLNRALRLIKVSISGLQLLGVV 212
Cdd:pfam00134   1 DIF-QYLRELELKYLPKPDYMdqqPDINPKMRAILIDWLVEVHEKFKLLPETLYLAVNYLDRFLSKKSVPKNKLQLVGVT 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 113678710  213 CLFLAAKREECLLPEVSELCYLMENAYSKKQLLRMERRVLIGLKFDL 259
Cdd:pfam00134  80 CLFIAAKYEEIYPPTVEDLVYITDNAYTREEILRMERLILETLNFDL 126
COG5024 COG5024
Cyclin [Cell division and chromosome partitioning];
133-319 7.66e-31

Cyclin [Cell division and chromosome partitioning];


Pssm-ID: 227357 [Multi-domain]  Cd Length: 440  Bit Score: 122.19  E-value: 7.66e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678710 133 YAWDIFSDMMRSQLLCTLPNADLPK--PFTDTTRAILVDWLIQVHEVFQFSEETLYLTVHLLNRALRLIKVSISGLQLLG 210
Cdd:COG5024  180 YASDIFEYLLKLELIDLPNPNYLIKqsLYEWSMRSILVDWLVEVHGKFGLLPETLFLAINIIDRFLSSRVVSLEKYQLVG 259

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678710 211 VVCLFLAAKREECLLPEVSELCYLMENAYSKKQLLRMERRVLIGLKFDLYHCPPLHFL--LISASIARCSDKVvwMARYL 288
Cdd:COG5024  260 ISALFIASKYEEVNCPSIKDLVYATDGAFTRDDIIRAERYMLEVLDFNISWPSPMSFLrrISKASDYDIFSRT--PAKFS 337

                        170       180       190
                 ....*....|....*....|....*....|.
gi 113678710 289 LELSLLEGRCVVYLPAQLAGAALRLARKILQ 319
Cdd:COG5024  338 SEISPVDYKFIQISPSWCAAAAMYLSRKILS 368
Cyclin_C pfam02984
Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 264-384 3.90e-15

Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the C-terminal domain.


Pssm-ID: 397230  Cd Length: 119  Bit Score: 71.12  E-value: 3.90e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678710  264 PLHFL--LISASIARCSDKVVWMARYLLELSLLEGRCVVYLPAQLAGAALRLARKILQeaaapeaEMAWCIASSIHIG-S 340
Cdd:pfam02984   3 PLSFLrrFSKAADYLHDLELRTLAKYLLELTLLDYDFLKYPPSLIAAAAVYLARKTLN-------SPEWTETLEHYTGyS 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 113678710  341 EAVLLSIMQIMAIAAARAQTRETRATFIKFSTVQTLHVSMHPAL 384
Cdd:pfam02984  76 EEDLKPCVKLLLELLLNAPSSKLQAVRRKYSSSKFMKVSTLPPL 119
CYCLIN_CCNO-like_rpt2 cd20537
second cyclin box found in cyclin-O (CCNO) and similar proteins; This subfamily is composed of ...
 264-319 3.53e-13

second cyclin box found in cyclin-O (CCNO) and similar proteins; This subfamily is composed of CCNO and similar proteins including Schizosaccharomyces pombe meiosis-specific cyclin rem1, Drosophila melanogaster G2/mitotic-specific cyclin-A (CCNA), and Candida albicans G1/S-specific cyclin CCN1, among others. Rem1 is required for pre-meiotic DNA synthesis and S phase progression. CCNA is essential for the control of the cell cycle at the G2/M (mitosis) transition. CCN1 is essential for the control of the cell cycle at the G1/S (start) transition and for maintenance of filamentous growth. CCNO is specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. It is involved in the activation of cyclin-dependent kinase 2. Members of this subfamily contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410240 [Multi-domain]  Cd Length: 91  Bit Score: 64.64  E-value: 3.53e-13
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 113678710 264 PLHFLLISASIARCSDKVVWMARYLLELSLLEGRCVVYLPAQLAGAALRLARKILQ 319
Cdd:cd20537    3 PLSFLRRYLSLLGLDEKVRHLARYLLELSLLDYEFLKYRPSLIAAAALYLARKILG 58
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 169-252 1.48e-12

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 62.61  E-value: 1.48e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678710   169 DWLIQVHEVFQFSEETLYLTVHLLNRALRLIKVSISGLQLLGVVCLFLAAKREECLLPEVSELCYLmeNAYSKKQLLRME 248
Cdd:smart00385   1 DFLRRVCKALNLDPETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLASKTEETPPWTKELVHYT--GYFTEEEILRME 78


                   ....
gi 113678710   249 RRVL 252
Cdd:smart00385  79 RLLL 82
CCL1 COG5333
Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision ...
 212-318 3.86e-04

Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit [Cell division and chromosome partitioning / Transcription / DNA replication, recombination, and repair];


Pssm-ID: 227640 [Multi-domain]  Cd Length: 297  Bit Score: 42.03  E-value: 3.86e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678710 212 VCLFLAAKREECLLpEVSELCYLMENAYS------KKQLLRMERRVLIGLKFDLY----HCPPLHFLLIsaSIARCSDKV 281
Cdd:COG5333   93 TCVYLACKVEDTPR-DISIESFEARDLWSeepkssRERILEYEFELLEALDFDLHvhhpYKYLEGFLKD--LQEKDKYKL 169

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 113678710 282 VWMARYLLELSLLEGRCVVYLPAQLAGAALRLARKIL 318
Cdd:COG5333  170 LQIAWKIINDALRTDLCLLYPPHIIALAALLIACEVL 206
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 266-319 2.23e-03

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 36.80  E-value: 2.23e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 113678710   266 HFLLISASIARCSDKVVWMARYLLELSLLEGRCVVYLPAQLAGAALRLARKILQ 319
Cdd:smart00385   1 DFLRRVCKALNLDPETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLASKTEE 54
 
Name Accession Description Interval E-value
CYCLIN_CNTD2 cd20542
cyclin box found in Cyclin N-terminal domain-containing protein 2 (CNTD2) and similar proteins; ...
 164-259 2.26e-46

cyclin box found in Cyclin N-terminal domain-containing protein 2 (CNTD2) and similar proteins; CNTD2 is an atypical cyclin upregulated in human cancer tissues. It promotes cell proliferation and migration, as well as increases tumor growth in vivo. It can function as a prognostic factor and drug target. CNTD2 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410245 [Multi-domain]  Cd Length: 96  Bit Score: 154.02  E-value: 2.26e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678710 164 RAILVDWLIQVHEVFQFSEETLYLTVHLLNRALRLIKVSISGLQLLGVVCLFLAAKREECLLPEVSELCYLMENAYSKKQ 243
Cdd:cd20542    1 RAILVDWLVQVQEHLELSTQTLHLAVALLDRYLSRQKISLSLLQLLGITCLFIACKFEERFPPEVATLCYLTDDSYSKKQ 80

                         90
                 ....*....|....*.
gi 113678710 244 LLRMERRVLIGLKFDL 259
Cdd:cd20542   81 VLRMERRVLRRLRFDL 96
CYCLIN_CCNB1-like_rpt1 cd20507
first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two ...
 133-257 4.21e-38

first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two B-type cyclins, CCNB1 and CCNB2, both of which are essential for the control of the cell cycle at the G2/M (mitosis) transition. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410211 [Multi-domain]  Cd Length: 130  Bit Score: 133.81  E-value: 4.21e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678710 133 YAWDIFSDMMRSQLLCTLPNADLP--KPFTDTTRAILVDWLIQVHEVFQFSEETLYLTVHLLNRALRLIKVSISGLQLLG 210
Cdd:cd20507    4 YVKDIYKYLRQLEKKYAIDPDYLSgqPEITERMRAILVDWLVEVHLKFKLLPETLYLTVNIIDRYLSKKQVPRKKLQLVG 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 113678710 211 VVCLFLAAKREECLLPEVSELCYLMENAYSKKQLLRMERRVLIGLKF 257
Cdd:cd20507   84 VTALLIASKYEEIYPPEIKDFVYITDNAYTREEILQMERDILKTLDF 130
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 136-259 1.38e-35

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 126.86  E-value: 1.38e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678710  136 DIFsDMMRSQLLCTLPNADLP---KPFTDTTRAILVDWLIQVHEVFQFSEETLYLTVHLLNRALRLIKVSISGLQLLGVV 212
Cdd:pfam00134   1 DIF-QYLRELELKYLPKPDYMdqqPDINPKMRAILIDWLVEVHEKFKLLPETLYLAVNYLDRFLSKKSVPKNKLQLVGVT 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 113678710  213 CLFLAAKREECLLPEVSELCYLMENAYSKKQLLRMERRVLIGLKFDL 259
Cdd:pfam00134  80 CLFIAAKYEEIYPPTVEDLVYITDNAYTREEILRMERLILETLNFDL 126
CYCLIN_CCNA_rpt1 cd20504
first cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, ...
 132-257 1.98e-34

first cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, CCNA1 and CCNA2. CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. Members in this family contain two cyclin boxes. The model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410208 [Multi-domain]  Cd Length: 128  Bit Score: 123.90  E-value: 1.98e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678710 132 TYAWDIFSDMMRSQLLCTlPNADLPKPFTDTT---RAILVDWLIQVHEVFQFSEETLYLTVHLLNRALRLIKVSISGLQL 208
Cdd:cd20504    1 EYADDIYEYLRESELKHR-PKPDYMRKQPDINpsmRSILVDWLVEVAEEYKLVPETLYLAVNYIDRFLSQMSVLRSKLQL 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 113678710 209 LGVVCLFLAAKREECLLPEVSELCYLMENAYSKKQLLRMERRVLIGLKF 257
Cdd:cd20504   80 VGTACMFIAAKYEEIYPPEVEEFVYITDDTYTKKQVLRMEHLVLKVLSF 128
CYCLIN_CLBs_yeast_rpt1 cd20568
first cyclin box found in yeast B-type cyclins; This subfamily includes Saccharomyces ...
 133-257 3.76e-31

first cyclin box found in yeast B-type cyclins; This subfamily includes Saccharomyces cerevisiae G2/mitotic-specific cyclins 1-4 (ScCLB1-4), S-phase entry cyclins 5-6 (ScCLB5-6), and Schizosaccharomyces pombe G2/mitotic-specific cyclins, cig1, cig2 and cdc13. ScCLB1-4 are essential for the control of the cell cycle at the G2/M (mitosis) transition. They interact with the CDC2 protein kinase to form maturation promoting factor (MPF). ScCLB5-6 interact with CDC28 and are involved in DNA replication in Saccharomyces cerevisiae. ScCLB5 is required for efficient progression through S phase and possibly for the normal progression through meiosis. ScCLB6 is involved in G1/S and or S phase progression. Cig1 is required for efficient passage of the G1/S transition. Cig2 and cdc13 are essential for the control of the cell cycle at the G2/M and G1/S (mitosis) transitions. They interact with the cdc2 protein kinase to form MPF. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410271  Cd Length: 134  Bit Score: 115.47  E-value: 3.76e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678710 133 YAWDIFsDMMRSQLLCTLPNA---DLPKPFTDTTRAILVDWLIQVHEVFQFSEETLYLTVHLLNRALRLIKVSISGLQLL 209
Cdd:cd20568    8 YVPEIF-EYLRELELKTLPNPnymDDQKELRWKMRGILVDWLVEVHEKFRLLPETLFLAVNIIDRFLSKRVVSLNKLQLV 86

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 113678710 210 GVVCLFLAAKREECLLPEVSELCYLMENAYSKKQLLRMERRVLIGLKF 257
Cdd:cd20568   87 GISALFIASKYEEVNSPSIKNFAYMTDGAYTVEDILRAERYMLNTLEF 134
COG5024 COG5024
Cyclin [Cell division and chromosome partitioning];
133-319 7.66e-31

Cyclin [Cell division and chromosome partitioning];


Pssm-ID: 227357 [Multi-domain]  Cd Length: 440  Bit Score: 122.19  E-value: 7.66e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678710 133 YAWDIFSDMMRSQLLCTLPNADLPK--PFTDTTRAILVDWLIQVHEVFQFSEETLYLTVHLLNRALRLIKVSISGLQLLG 210
Cdd:COG5024  180 YASDIFEYLLKLELIDLPNPNYLIKqsLYEWSMRSILVDWLVEVHGKFGLLPETLFLAINIIDRFLSSRVVSLEKYQLVG 259

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678710 211 VVCLFLAAKREECLLPEVSELCYLMENAYSKKQLLRMERRVLIGLKFDLYHCPPLHFL--LISASIARCSDKVvwMARYL 288
Cdd:COG5024  260 ISALFIASKYEEVNCPSIKDLVYATDGAFTRDDIIRAERYMLEVLDFNISWPSPMSFLrrISKASDYDIFSRT--PAKFS 337

                        170       180       190
                 ....*....|....*....|....*....|.
gi 113678710 289 LELSLLEGRCVVYLPAQLAGAALRLARKILQ 319
Cdd:COG5024  338 SEISPVDYKFIQISPSWCAAAAMYLSRKILS 368
CYCLIN_AtCycB-like_rpt1 cd20567
first cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; ...
 164-257 1.89e-29

first cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; Plant B-type cyclins (CycBs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycBs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410270  Cd Length: 147  Bit Score: 111.28  E-value: 1.89e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678710 164 RAILVDWLIQVHEVFQFSEETLYLTVHLLNRALRLIKVSISGLQLLGVVCLFLAAKREECLLPEVSELCYLMENAYSKKQ 243
Cdd:cd20567   54 RAILIDWLIEVHLKFELMPETLYLTVNLIDRFLSVKQVPRKELQLVGVTAMLIASKYEEIWAPEVNDFVYISDNAYTRKQ 133

                         90
                 ....*....|....
gi 113678710 244 LLRMERRVLIGLKF 257
Cdd:cd20567  134 ILVMEKTMLNTLEF 147
CYCLIN_AtCycA_like_rpt1 cd20562
first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; ...
 132-258 2.84e-29

first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; Plant A-type cyclins (CycAs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycAs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410265  Cd Length: 136  Bit Score: 110.58  E-value: 2.84e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678710 132 TYAWDIFSDMMRSQLLcTLPNAD----LPKPFTDTTRAILVDWLIQVHEVFQFSEETLYLTVHLLNRALRLIKVSISGLQ 207
Cdd:cd20562    7 LYATDIYLNLRVAELK-RRPLPDymekIQRDITPSMRGILVDWLVEVAEEYKLVPDTLYLTVSYIDRFLSGNYVNRQRLQ 85

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 113678710 208 LLGVVCLFLAAKREECLLPEVSELCYLMENAYSKKQLLRMERRVLIGLKFD 258
Cdd:cd20562   86 LLGVSCMLIASKYEEICAPQVEEFCYITDNTYTKQEVLEMEIDVLNALQFE 136
CYCLIN_CCNA2_rpt1 cd20561
first cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1/S ...
 133-258 5.00e-27

first cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. It is significantly over-expressed in various cancer types, and can be used as a prognostic biomarker for estrogen receptor positive (ER+) breast cancer and tamoxifen resistance. CCNA2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410264 [Multi-domain]  Cd Length: 131  Bit Score: 104.37  E-value: 5.00e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678710 133 YAWDIFSDMMRSQLLCTlPNADLPKPFTDTT---RAILVDWLIQVHEVFQFSEETLYLTVHLLNRALRLIKVSISGLQLL 209
Cdd:cd20561    4 YHEDIHTYLREMEVKCK-PKVGYMKKQPDITnsmRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQLV 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 113678710 210 GVVCLFLAAKREECLLPEVSELCYLMENAYSKKQLLRMERRVLIGLKFD 258
Cdd:cd20561   83 GTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLTFD 131
CYCLIN_CCNB3_rpt1 cd20508
first cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is ...
 133-258 2.21e-25

first cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is a mitotic B-type cyclin that promotes the metaphase-anaphase transition. It controls anaphase onset independent of spindle assembly checkpoint in meiotic oocytes. CCNB3 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410212 [Multi-domain]  Cd Length: 142  Bit Score: 100.41  E-value: 2.21e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678710 133 YAWDIFSDMMRSQLLCTLPN-----ADLpkpfTDTTRAILVDWLIQVHEVFQFSEETLYLTVHLLNRALRLIKVSISGLQ 207
Cdd:cd20508   16 YAKDIFDYMKEREEKFVVPDylekqTEL----TPSMRAILVDWLVEVQENFELNHETLYLAVKLVDLYLSKKVVKKEKLQ 91

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 113678710 208 LLGVVCLFLAAKREECLLPEVSELCYLMENAYSKKQLLRMERRVLIGLKFD 258
Cdd:cd20508   92 LLGATAILIASKFDERCPPCVDDFLYICDDAYTREELLKMEREILKTLDFD 142
CYCLIN_CCNB2_rpt1 cd20566
first cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 is ...
 164-257 5.91e-25

first cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for progression through meiosis. CCNB2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410269 [Multi-domain]  Cd Length: 133  Bit Score: 98.78  E-value: 5.91e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678710 164 RAILVDWLIQVHEVFQFSEETLYLTVHLLNRALRLIKVSISGLQLLGVVCLFLAAKREECLLPEVSELCYLMENAYSKKQ 243
Cdd:cd20566   40 RAILVDWLVQVHSRFQLLQETLYMCVAIMDRFLQVQPVSRKKLQLVGVTALLLASKYEEMYSPEIGDFVYITDNAYTKAQ 119

                         90
                 ....*....|....
gi 113678710 244 LLRMERRVLIGLKF 257
Cdd:cd20566  120 IREMEMLILKELNF 133
CYCLIN_CCNO_rpt1 cd20536
first cyclin box found in cyclin-O (CCNO) and similar proteins; CCNO is specifically required ...
 163-255 3.68e-24

first cyclin box found in cyclin-O (CCNO) and similar proteins; CCNO is specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. It acts downstream of MCIDAS (multiciliate differentiation and DNA synthesis associated cell cycle protein) to promote mother centriole amplification and maturation in preparation for apical docking. CCNO is involved in the activation of cyclin-dependent kinase 2. CCNO contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410239  Cd Length: 93  Bit Score: 95.47  E-value: 3.68e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678710 163 TRAILVDWLIQVHEVFQFSEETLYLTVHLLNRALRLIKVSISGLQLLGVVCLFLAAKREECLLPEVSELCYLMENAYSKK 242
Cdd:cd20536    1 MRAKLISWLIPVHRHFNLSQETLFLAVNILDRFLATTPVARDCFQLLGVTSLLIACKQEEIYPPEVKDLLALCCGAYTRE 80

                         90
                 ....*....|...
gi 113678710 243 QLLRMERRVLIGL 255
Cdd:cd20536   81 QICNLECIILTKL 93
CYCLIN_CCNA1_rpt1 cd20560
first cyclin box found in cyclin-A1 (CCNA1); CCNA1 may primarily function in the control of ...
 156-258 1.13e-23

first cyclin box found in cyclin-A1 (CCNA1); CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410263  Cd Length: 163  Bit Score: 96.45  E-value: 1.13e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678710 156 PKPF--------TDTTRAILVDWLIQVHEVFQFSEETLYLTVHLLNRALRLIKVSISGLQLLGVVCLFLAAKREECLLPE 227
Cdd:cd20560   53 PKPGymrkqpdiTTGMRTILVDWLVEVGEEYKLQTETLYLAVNYLDRFLSCMSVLRGKLQLVGTAAILLASKYEEIYPPE 132

                         90       100       110
                 ....*....|....*....|....*....|.
gi 113678710 228 VSELCYLMENAYSKKQLLRMERRVLIGLKFD 258
Cdd:cd20560  133 VDEFVYITDDTYTKKQLLRMEHLLLKVLAFD 163
CYCLIN_CCNB1_rpt1 cd20565
first cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1); CCNB1 is essential for the ...
 151-257 4.77e-23

first cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1); CCNB1 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for embryo development. Over-expression of human CCNB1 has been found in numerous cancers and has been associated with tumor aggressiveness. CCNB1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410268 [Multi-domain]  Cd Length: 129  Bit Score: 93.40  E-value: 4.77e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678710 151 PNADLPKPFTDTTRAILVDWLIQVHEVFQFSEETLYLTVHLLNRALRLIKVSISGLQLLGVVCLFLAAKREECLLPEVSE 230
Cdd:cd20565   23 PKYLEGQEVTGNMRAILIDWLVQVQMKFRLLQETMYMTVAIIDRFLQNNPVPKKMLQLVGVTAMFIASKYEEMYPPEIGD 102

                         90       100
                 ....*....|....*....|....*..
gi 113678710 231 LCYLMENAYSKKQLLRMERRVLIGLKF 257
Cdd:cd20565  103 FAFVTDNTYTKHQIRQMEMKILRALDF 129
CYCLIN_CCNE_rpt1 cd20519
first cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two ...
 160-257 3.57e-19

first cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two E-type cyclins, CCNE1 and CCNE2. CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complexes. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410223  Cd Length: 131  Bit Score: 82.75  E-value: 3.57e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678710 160 TDTTRAILVDWLIQVHEVFQFSEETLYLTVHLLNRALRLIK-VSISGLQLLGVVCLFLAAKREECLLPEVSELCYLMENA 238
Cdd:cd20519   33 QPRMRAILLDWLMEVCEVYRLHRETFYLAVDFVDRYLSTQTnVPKTQLQLIGITCLFIAAKLEEIYPPKLSEFAYVTDGA 112

                         90
                 ....*....|....*....
gi 113678710 239 YSKKQLLRMERRVLIGLKF 257
Cdd:cd20519  113 CTEDEILTMELIILKALNW 131
Cyclin_C pfam02984
Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 264-384 3.90e-15

Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the C-terminal domain.


Pssm-ID: 397230  Cd Length: 119  Bit Score: 71.12  E-value: 3.90e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678710  264 PLHFL--LISASIARCSDKVVWMARYLLELSLLEGRCVVYLPAQLAGAALRLARKILQeaaapeaEMAWCIASSIHIG-S 340
Cdd:pfam02984   3 PLSFLrrFSKAADYLHDLELRTLAKYLLELTLLDYDFLKYPPSLIAAAAVYLARKTLN-------SPEWTETLEHYTGyS 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 113678710  341 EAVLLSIMQIMAIAAARAQTRETRATFIKFSTVQTLHVSMHPAL 384
Cdd:pfam02984  76 EEDLKPCVKLLLELLLNAPSSKLQAVRRKYSSSKFMKVSTLPPL 119
CYCLIN_CCNF_rpt1 cd20521
first cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, also ...
 161-247 6.86e-15

first cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, also termed F-box only protein 1 (FBXO1), is a substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication. It is the largest among all cyclins and oscillates in the cell cycle like other cyclins. CCNF contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410225  Cd Length: 95  Bit Score: 69.65  E-value: 6.86e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678710 161 DTTRAILVDWLIQVHEVFQFSEETLYLTVHLLNRALRLIKVSISGLQLLGVVCLFLAAKREECLLPEVSELCYLMENAYS 240
Cdd:cd20521    1 DTMRYILVDWLVEVATMKDFSSLTLHVAVSCVDRYLMVRKVPRSKLQLLGIACMVIATRFLGKDILTIREAAWLTDNTYK 80


                 ....*..
gi 113678710 241 KKQLLRM 247
Cdd:cd20521   81 YEDVVRM 87
CYCLIN_CCND_rpt1 cd20515
first cyclin box found in cyclin-D (CCND) family; The CCND family includes three ...
 164-258 8.78e-15

first cyclin box found in cyclin-D (CCND) family; The CCND family includes three mitogen-induced D-type cyclins, CCND1, CCND2 and CCND3, which function as regulatory subunits of the cyclin-dependent kinases CDK4 and CDK6, that drive progression through the G1 phase of the cell cycle. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410219  Cd Length: 150  Bit Score: 71.18  E-value: 8.78e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678710 164 RAILVDWLIQVHEVFQFSEETLYLTVHLLNRALRLIKVSISGLQLLGVVCLFLAAKREECLLPEVSELCYLMENAYSKKQ 243
Cdd:cd20515   56 RKMVTTWMLEVCEEQNCEEEVFPLAVNYLDRFLSLVPIRKSQLQLLGAVCLFLASKLKETIPLTAEKLCIYTDNSITLQE 135

                         90
                 ....*....|....*
gi 113678710 244 LLRMERRVLIGLKFD 258
Cdd:cd20515  136 LLDWELLVLTKLKWD 150
CYCLIN_CCNE2_rpt1 cd20580
first cyclin box found in G1/S-specific cyclin-E2 (CCNE2); CCNE2 is essential for the control ...
 164-257 1.23e-14

first cyclin box found in G1/S-specific cyclin-E2 (CCNE2); CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complexes. CCNE2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410283 [Multi-domain]  Cd Length: 137  Bit Score: 70.26  E-value: 1.23e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678710 164 RAILVDWLIQVHEVFQFSEETLYLTVHLLNR-ALRLIKVSISGLQLLGVVCLFLAAKREECLLPEVSELCYLMENAYSKK 242
Cdd:cd20580   43 RSILLDWLLEVCEVYTLHRETFYLAQDFFDRfMLTQKNINKSMLQLIGITSLFIASKLEEIYPPKLHEFAYVTDGACSED 122

                         90
                 ....*....|....*
gi 113678710 243 QLLRMERRVLIGLKF 257
Cdd:cd20580  123 DILDMELIILKALKW 137
CYCLIN_CCNE1_rpt1 cd20579
first cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control ...
 164-257 1.99e-14

first cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410282 [Multi-domain]  Cd Length: 137  Bit Score: 69.91  E-value: 1.99e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678710 164 RAILVDWLIQVHEVFQFSEETLYLTVHLLNRALRLIK-VSISGLQLLGVVCLFLAAKREECLLPEVSELCYLMENAYSKK 242
Cdd:cd20579   43 RAILLDWLMEVCEVYKLHRETFYLAQDFFDRFMATQEnVVKTRLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACTED 122

                         90
                 ....*....|....*
gi 113678710 243 QLLRMERRVLIGLKF 257
Cdd:cd20579  123 EILSMELIIMKALKW 137
CYCLIN_CCNO-like_rpt2 cd20537
second cyclin box found in cyclin-O (CCNO) and similar proteins; This subfamily is composed of ...
 264-319 3.53e-13

second cyclin box found in cyclin-O (CCNO) and similar proteins; This subfamily is composed of CCNO and similar proteins including Schizosaccharomyces pombe meiosis-specific cyclin rem1, Drosophila melanogaster G2/mitotic-specific cyclin-A (CCNA), and Candida albicans G1/S-specific cyclin CCN1, among others. Rem1 is required for pre-meiotic DNA synthesis and S phase progression. CCNA is essential for the control of the cell cycle at the G2/M (mitosis) transition. CCN1 is essential for the control of the cell cycle at the G1/S (start) transition and for maintenance of filamentous growth. CCNO is specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. It is involved in the activation of cyclin-dependent kinase 2. Members of this subfamily contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410240 [Multi-domain]  Cd Length: 91  Bit Score: 64.64  E-value: 3.53e-13
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 113678710 264 PLHFLLISASIARCSDKVVWMARYLLELSLLEGRCVVYLPAQLAGAALRLARKILQ 319
Cdd:cd20537    3 PLSFLRRYLSLLGLDEKVRHLARYLLELSLLDYEFLKYRPSLIAAAALYLARKILG 58
CYCLIN_CCNI-like cd20526
cyclin box found in cyclin-I (CCNI) and similar proteins; CCNI is an atypical cyclin because ...
 168-259 3.89e-13

cyclin box found in cyclin-I (CCNI) and similar proteins; CCNI is an atypical cyclin because it is most abundant in post-mitotic cells. It is involved in various biological processes, such as cell survival, angiogenesis, cell differentiation, and cell cycle progression. CCNI contains a typical cyclin box near the N-terminus and a PEST sequence near the C-terminus. The cyclin box is a protein binding domain.


Pssm-ID: 410230  Cd Length: 99  Bit Score: 65.03  E-value: 3.89e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678710 168 VDWLIQVHEVFQFSEETLYLTVHLLNRALRLIKVSISGLQLLGVVCLFLAAK--REECLLPEVSELCYLMENAYSKKQLL 245
Cdd:cd20526    6 VRWLAELNSQFKFYPETFALAVSILDRFLASVKARPKYLRCIAISCLFLAAKtnEEDEVIPSTKDLVRVSKCGCSVAEVL 85

                         90
                 ....*....|....
gi 113678710 246 RMERRVLIGLKFDL 259
Cdd:cd20526   86 RMERIILDKLHWDL 99
CYCLIN_CCND3_rpt1 cd20575
first cyclin box found in G1/S-specific cyclin-D3 (CCND3) and similar proteins; CCND3 is a ...
 164-258 1.08e-12

first cyclin box found in G1/S-specific cyclin-D3 (CCND3) and similar proteins; CCND3 is a regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. In skeletal muscle, CCND3 plays a unique function in controlling the proliferation/differentiation balance of myogenic progenitor cells. CCND3 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410278  Cd Length: 150  Bit Score: 65.40  E-value: 1.08e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678710 164 RAILVDWLIQVHEVFQFSEETLYLTVHLLNRALRLIKVSISGLQLLGVVCLFLAAKREECLLPEVSELCYLMENAYSKKQ 243
Cdd:cd20575   56 RKMLAYWMLEVCEEQKCEEEVFPLAMNYVDRYLSCVPTRKAQLQLLGAVCMLLASKLRETTPLTIEKLCIYTDNSISPRQ 135

                         90
                 ....*....|....*
gi 113678710 244 LLRMERRVLIGLKFD 258
Cdd:cd20575  136 LLDWEILVLGKLKWD 150
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 169-252 1.48e-12

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 62.61  E-value: 1.48e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678710   169 DWLIQVHEVFQFSEETLYLTVHLLNRALRLIKVSISGLQLLGVVCLFLAAKREECLLPEVSELCYLmeNAYSKKQLLRME 248
Cdd:smart00385   1 DFLRRVCKALNLDPETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLASKTEETPPWTKELVHYT--GYFTEEEILRME 78


                   ....
gi 113678710   249 RRVL 252
Cdd:smart00385  79 RLLL 82
CYCLIN_CCND1_rpt1 cd20573
first cyclin box found in G1/S-specific cyclin-D1 (CCND1); CCND1, also called B-cell lymphoma ...
 164-258 5.01e-12

first cyclin box found in G1/S-specific cyclin-D1 (CCND1); CCND1, also called B-cell lymphoma 1 protein (BCL-1), or BCL-1 oncogene, or PRAD1 oncogene, is a regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1. The complex also regulates the cell-cycle during G(1)/S transition. It is an important cell cycle regulatory protein involved in carcinogenesis of various human cancers. CCND1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410276  Cd Length: 149  Bit Score: 63.46  E-value: 5.01e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678710 164 RAILVDWLIQVHEVFQFSEETLYLTVHLLNRALRLIKVSISGLQLLGVVCLFLAAKREECLLPEVSELCYLMENAYSKKQ 243
Cdd:cd20573   55 RKIVATWMLEVCEEQKCEEEVFPLAMNYLDRFLSVEPTKKSRLQLLGATCMFLASKMKETIPLTAEKLCIYTDNSIRPEE 134

                         90
                 ....*....|....*
gi 113678710 244 LLRMERRVLIGLKFD 258
Cdd:cd20573  135 LLQMELLVLNKLKWD 149
CYCLIN_ScCLN_like cd20559
cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclins (ScCLNs) and similar ...
 167-258 1.42e-11

cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclins (ScCLNs) and similar proteins; ScCLNs, including ScCLN1-3, are essential for the control of the cell cycle at the G1/S (start) transition in Saccharomyces. ScCLN1 and ScCLN2 interact with the CDC28 protein kinase to form maturation promoting factor (MPF). ScCLN3 may be an upstream activator of the G1 cyclins that directly initiate G1/S transition. This family also includes Schizosaccharomyces pombe cyclin puc1, which contributes to negative regulation of the timing of sexual development in fission yeast, and functions at the transition between cycling and non-cycling cells. It interacts with protein kinase A. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410262 [Multi-domain]  Cd Length: 95  Bit Score: 60.48  E-value: 1.42e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678710 167 LVDWLIQVHEVFQFSEETLYLTVHLLNRALRLIKVSISGLQLLGVVCLFLAAKREEC-----LLPEVSELCylmENAYSK 241
Cdd:cd20559    2 LLDFLFELHVELRLSPQTFFLSVNLIDRYCSKRIVLKKHYQLVGCTCLWIASKFWESkarvpLLSELSKMC---CNSYGE 78

                         90
                 ....*....|....*..
gi 113678710 242 KQLLRMERRVLIGLKFD 258
Cdd:cd20559   79 ELFIQMEMHILNTLNWD 95
CYCLIN_CCNB1-like_rpt2 cd20509
second cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two ...
 264-371 1.51e-11

second cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two B-type cyclins, CCNB1 and CCNB2, both of which are essential for the control of the cell cycle at the G2/M (mitosis) transition. Members in this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410213  Cd Length: 111  Bit Score: 60.70  E-value: 1.51e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678710 264 PLHFLLISASIARCSDKVVWMARYLLELSLLEGRCVVYLPAQLAGAALRLARKILqeaaapeAEMAWcIASSIHIG--SE 341
Cdd:cd20509    3 PLHFLRRFSKAGGADAQKHTLAKYLMELTLLDYDMVHYKPSEIAAAALCLSRKIL-------DEPEW-TPTLEHYStySE 74

                         90       100       110
                 ....*....|....*....|....*....|
gi 113678710 342 AVLLSIMQIMAIAAARAQTRETRATFIKFS 371
Cdd:cd20509   75 EDLLPIVQKMAKLVVKSQTSKYQAVKNKYS 104
CYCLIN_CCNJ-like_rpt1 cd20528
first cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ ...
 167-257 8.76e-11

first cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ and CCNJ-like. CCNJ may regulate the cell cycle or transcription. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410231 [Multi-domain]  Cd Length: 103  Bit Score: 58.38  E-value: 8.76e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678710 167 LVDWLIQVHEVFQFSEETLYLTVHLLNRALRLIKVSISGLQLLGVVCLFLAAKREEC--LLPEVSEL-CYLMENAYSKKQ 243
Cdd:cd20528   10 LVDWLAVVSERLKLSDTTLHLAVYLLDRFMDRYDISEDQLHLVALTCLLLAAKFEELddNIPKISDLnRYLCNSVYSKQE 89

                         90
                 ....*....|....
gi 113678710 244 LLRMERRVLIGLKF 257
Cdd:cd20528   90 YLQMELLILEFFQW 103
CYCLIN_AtCycD-like_rpt1 cd20543
first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta ...
 164-256 1.93e-10

first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta family cyclins, including a group of G1/S-specific D-type cyclins from Arabidopsis thaliana which may activate the cell cycle in the root apical meristem (RAM) and promote embryonic root (radicle) protrusion. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410246  Cd Length: 99  Bit Score: 57.33  E-value: 1.93e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678710 164 RAILVDWLIQVHEVFQFSEETLYLTVHLLNRAL---RLIKVSISGLQLLGVVCLFLAAKREECLLPEVSEL-CYLMENAY 239
Cdd:cd20543    2 RNEAIDWILKVRSRYGFGPLTAYLAVNYLDRFLssyDLPKDKPWMLQLLAVACLSLAAKMEETDVPLLVDLqVEEPKYVF 81

                         90
                 ....*....|....*..
gi 113678710 240 SKKQLLRMERRVLIGLK 256
Cdd:cd20543   82 EAKTIQRMELLVLSTLE 98
CYCLIN_CCND2_rpt1 cd20574
first cyclin box found in G1/S-specific cyclin-D2 (CCND2); CCND2 is a regulatory component of ...
 157-258 2.09e-10

first cyclin box found in G1/S-specific cyclin-D2 (CCND2); CCND2 is a regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. It is a critical mediator of exercise-induced cardiac hypertrophy. It also acts as a regulator of cell cycle proteins affecting SAMHD1-mediated HIV-1 restriction in non-proliferating macrophages. CCND2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410277  Cd Length: 150  Bit Score: 58.85  E-value: 2.09e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678710 157 KPFTdttRAILVDWLIQVHEVFQFSEETLYLTVHLLNRALRLIKVSISGLQLLGVVCLFLAAKREECLLPEVSELCYLME 236
Cdd:cd20574   52 QPFM---RRMVATWMLEVCEEQKCEEEVFPLAMNYLDRFLAVVPTRKCHLQLLGAVCMFLASKLKETIPLTAEKLCIYTD 128

                         90       100
                 ....*....|....*....|..
gi 113678710 237 NAYSKKQLLRMERRVLIGLKFD 258
Cdd:cd20574  129 NSIKPQELLEWELVVLGKLKWN 150
CYCLIN_SF cd00043
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ...
 167-250 7.91e-10

Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box.


Pssm-ID: 410207 [Multi-domain]  Cd Length: 82  Bit Score: 55.11  E-value: 7.91e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678710 167 LVDWLIQVHEVFQFSEETLYLTVHLLNRALRLIKVSISGLQLLGVVCLFLAAKREECLLPeVSELCYLMEnaYSKKQLLR 246
Cdd:cd00043    2 AVDFIRRLCSKLGLPEEVLELAIELLDRFLSKGLLLGRSPELIAAACLYLACKLEELPRT-LKEIAKVSG--VSEKELRK 78


                 ....
gi 113678710 247 MERR 250
Cdd:cd00043   79 AEKE 82
CYCLIN_CCNG1 cd20583
cyclin box found in cyclin-G1 (CCNG1) and similar proteins; CCNG1 is the only cyclin that has ...
 164-252 3.17e-08

cyclin box found in cyclin-G1 (CCNG1) and similar proteins; CCNG1 is the only cyclin that has either positive or negative effects on cell growth. It is associated with G2/M phase arrest in response to DNA damage. It is also involved in the development of human carcinoma. CCNG1 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410286  Cd Length: 98  Bit Score: 50.98  E-value: 3.17e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678710 164 RAILVDWLIQVHEVFQFSEETLYLTVHLLNRALRLIKVSISGLQLLGVVCLFLAAK--REECLLPEVSELCYLMENAYSK 241
Cdd:cd20583    2 RDFEVKDLLSLTQFFGFSTETFSLAVNLLDRFLAKMKVQPKHLGCVGLSCFYLAVKaiEEERNVPLATDLIRISQYRFTV 81

                         90
                 ....*....|.
gi 113678710 242 KQLLRMERRVL 252
Cdd:cd20583   82 SDMMRMEKIIL 92
CYCLIN_vCyC_rpt1 cd20517
first cyclin box found in viral cyclin (v-cyclin); v-Cyclin modulates host cell cycle ...
 159-257 1.54e-07

first cyclin box found in viral cyclin (v-cyclin); v-Cyclin modulates host cell cycle progression and apoptotic signaling pathways. It forms an active kinase complex with cellular CDK6, a cellular cyclin-dependent kinase known to interact with cellular type D cyclins. v-Cyclin belongs to Cyclin D subfamily. It contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410221  Cd Length: 99  Bit Score: 49.10  E-value: 1.54e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678710 159 FTDTTRAILVDWLIQVHEVFQFSEETLYLTVHLLNRALRLIKVSISGLQLLGVVCLFLAAKREECLLPEVSELCYLMENA 238
Cdd:cd20517    1 VTSDNRKILLTWMFLVCESFELDKNVFPLAVSLLDRLLLKKQGTKETLQKTGAACLLIASKIRTVKPITVSKLTYLSCDC 80

                         90
                 ....*....|....*....
gi 113678710 239 YSKKQLLRMERRVLIGLKF 257
Cdd:cd20517   81 FTNLELINQEKDILEALKW 99
CYCLIN_CCNB2_rpt2 cd20570
second cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 ...
 264-384 2.05e-07

second cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for progression through meiosis. CCNB2 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410273  Cd Length: 119  Bit Score: 49.11  E-value: 2.05e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678710 264 PLHFLLISASIARCSDKVVWMARYLLELSLLEGRCVVYLPAQLAGAALRLARKILQeaaapeaEMAWCIASSIHIG-SEA 342
Cdd:cd20570    3 PLHFLRRASKAGSADVEKHTLAKYLMELTLIDYDMVHYHPSEIAAAALCLSQKVLD-------GGKWSLTQQYYTGyTED 75

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 113678710 343 VLLSIMQIMAIAAARAQTRETRATFI--KFSTVQTLHVSMHPAL 384
Cdd:cd20570   76 DLKPIMQHMAKNVVKVNEGLTKHVAVknKYASSKLMKISTIPQL 119
CYCLIN_CCNB1_rpt2 cd20569
second cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1) and similar proteins; CCNB1 ...
 264-386 2.19e-07

second cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1) and similar proteins; CCNB1 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for embryo development. Over-expression of human CCNB1 has been found in numerous cancers and has been associated with tumor aggressiveness. CCNB1 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410272  Cd Length: 121  Bit Score: 49.12  E-value: 2.19e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678710 264 PLHFLLISASIARCSDKVVWMARYLLELSLLEGRCVVYLPAQLAGAALRLARKILQeaaapeaEMAWCIASSIHIG-SEA 342
Cdd:cd20569    3 PLHFLRRASKIGEVDVEQHTLAKYLMELTMVDYDMVHFPPSQIAAAAFCLALKILD-------NGEWTPTLQHYMSyTEE 75

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 113678710 343 VLLSIMQIMAIAAARAQTRETRATFIK--FSTVQTLHVSMHPALKA 386
Cdd:cd20569   76 SLLPVMQHMAKNVVKVNQGLTKHMTVKnkYASSKQMKISTLPQLNS 121
CYCLIN_CCNG2 cd20584
cyclin box found in cyclin-G2 (CCNG2) and similar proteins; CCNG2 may play a role in growth ...
 178-249 6.87e-07

cyclin box found in cyclin-G2 (CCNG2) and similar proteins; CCNG2 may play a role in growth regulation and in negative regulation of cell cycle progression. It has been identified as a tumor suppressor in several cancers. CCNG2 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410287  Cd Length: 96  Bit Score: 47.15  E-value: 6.87e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 113678710 178 FQFSEETLYLTVHLLNRALRLIKVSISGLQLLGVVCLFLAAK--REECLLPEVSELCYLMENAYSKKQLLRMER 249
Cdd:cd20584   16 FGFSTETFVLAVNILDRFLALMKVKPKHLSCIGICCFHLAARvvEEECNIPSSHDLIRISQCKCTVSDLKRMEK 89
CYCLIN_CCNB3_rpt2 cd20510
second cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 ...
 264-319 1.33e-06

second cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is a mitotic B-type cyclin that promotes the metaphase-anaphase transition. It controls anaphase onset independent of spindle assembly checkpoint in meiotic oocytes. CCNB3 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410214  Cd Length: 115  Bit Score: 46.89  E-value: 1.33e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 113678710 264 PLHFLLISASIARCSDKVVWMARYLLELSLLEGRCVVYLPAQLAGAALRLARKILQ 319
Cdd:cd20510    3 SYRFLRRYAKCARASMETLTLARYILELSLMEYQFVQERASKLAAAALLLALKMKN 58
CYCLIN_CCNG cd20523
cyclin box found in the cyclin-G (CCNG) family; The CCNG family includes two cyclins, CCNG1 ...
 168-252 1.61e-06

cyclin box found in the cyclin-G (CCNG) family; The CCNG family includes two cyclins, CCNG1 and CCNG2. CCNG1 is the only cyclin that has either positive or negative effects on cell growth. It is associated with G2/M phase arrest in response to DNA damage. It is also involved in the development of human carcinoma. CCNG2 may play a role in growth regulation and in negative regulation of cell cycle progression. It has been identified as a tumor suppressor in several cancers. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410227  Cd Length: 94  Bit Score: 46.19  E-value: 1.61e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678710 168 VDWLIQVHEVFQFSEETLYLTVHLLNRALRLIKVSISGLQLLGVVCLFLAAK--REECLLPEVSELCYLMENAYSKKQLL 245
Cdd:cd20523    5 VDRLRCLHRFYGFSPETFALAVNLLDRFLSKVKVKPKHLACITVSCFHIAIKsvEEDQNIPSAEDLIRISQCGCTAADLM 84


                 ....*..
gi 113678710 246 RMERRVL 252
Cdd:cd20523   85 RMEGIIL 91
CYCLIN_AtCycB-like_rpt2 cd20511
second cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; ...
 264-382 8.46e-06

second cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; Plant B-type cyclins (CycBs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycBs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410215  Cd Length: 117  Bit Score: 44.60  E-value: 8.46e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678710 264 PLHFLLISASIARCSDKVVWMARYLLELSLLEGRCVVYLPAQLAGAALRLARKILQeaaapeAEMAWCIASSIHIG-SEA 342
Cdd:cd20511    3 PYVFLVRFLKAAQSDKKLENLAFFLVELGLVEYEMLKYSPSMLAASAVYTARCTLN------KTPEWTSTLEFHTGySES 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 113678710 343 VLLSIMQIMAIAAARAQTRETRATFIKFSTVQTLHVSMHP 382
Cdd:cd20511   77 QLMECARLMVRLHSKAGTGKLTAVYKKYSSSKFGAVALLP 116
CYCLIN_CLBs_yeast_rpt2 cd20512
second cyclin box found in yeast B-type cyclins; The family includes Saccharomyces cerevisiae ...
 264-318 1.38e-05

second cyclin box found in yeast B-type cyclins; The family includes Saccharomyces cerevisiae G2/mitotic-specific cyclins 1-4 (ScCLB1-4), S-phase entry cyclins 5-6 (ScCLB5-6), and Schizosaccharomyces pombe G2/mitotic-specific cyclins, cig1, cig2 and cdc13. ScCLB1-4 are essential for the control of the cell cycle at the G2/M (mitosis) transition. They interact with the CDC2 protein kinase to form maturation promoting factor (MPF). ScCLB5-6 interact with CDC28 and are involved in DNA replication in Saccharomyces cerevisiae. ScCLB5 is required for efficient progression through S phase and possibly for the normal progression through meiosis. ScCLB6 is involved in G1/S and or S phase progression. Cig1 is required for efficient passage of the G1/S transition. Cig2 and cdc13 are essential for the control of the cell cycle at the G2/M and G1/S (mitosis) transition. They interact with the cdc2 protein kinase to form MPF. Members in this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410216  Cd Length: 116  Bit Score: 43.76  E-value: 1.38e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 113678710 264 PLHFL-LISASIARCsDKVVWMARYLLELSLLEGRCVVYLPAQLAGAALRLARKIL 318
Cdd:cd20512    2 PMNFLrRISKADDYD-IQTRTLAKYLLEITILDHRFLGYPPSLLAAAAMYLARKML 56
CYCLIN_CCNA_rpt2 cd20505
second cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, ...
 267-315 2.75e-04

second cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, CCNA1 and CCNA2. CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. Members in this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410209 [Multi-domain]  Cd Length: 110  Bit Score: 39.97  E-value: 2.75e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 113678710 267 FLLISASIARCSDKVVWMARYLLELSLLEGRCVV-YLPAQLAGAALRLAR 315
Cdd:cd20505    6 FLERFLKHSNADEKTKSLAMYLCELSLIDADPYLkYLPSVIAAAAVCLAN 55
CYCLIN_AtCycA-like_rpt2 cd20506
second cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; ...
 284-318 3.45e-04

second cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; Plant A-type cyclins (CycAs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycAs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410210  Cd Length: 111  Bit Score: 39.92  E-value: 3.45e-04
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 113678710 284 MARYLLELSLLEGRCVVYLPAQLAGAALRLARKIL 318
Cdd:cd20506   26 LANYLAELSLLDYEFLKYLPSLIAASAVFLARHTL 60
CCL1 COG5333
Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision ...
 212-318 3.86e-04

Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit [Cell division and chromosome partitioning / Transcription / DNA replication, recombination, and repair];


Pssm-ID: 227640 [Multi-domain]  Cd Length: 297  Bit Score: 42.03  E-value: 3.86e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678710 212 VCLFLAAKREECLLpEVSELCYLMENAYS------KKQLLRMERRVLIGLKFDLY----HCPPLHFLLIsaSIARCSDKV 281
Cdd:COG5333   93 TCVYLACKVEDTPR-DISIESFEARDLWSeepkssRERILEYEFELLEALDFDLHvhhpYKYLEGFLKD--LQEKDKYKL 169

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 113678710 282 VWMARYLLELSLLEGRCVVYLPAQLAGAALRLARKIL 318
Cdd:COG5333  170 LQIAWKIINDALRTDLCLLYPPHIIALAALLIACEVL 206
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 266-319 2.23e-03

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 36.80  E-value: 2.23e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 113678710   266 HFLLISASIARCSDKVVWMARYLLELSLLEGRCVVYLPAQLAGAALRLARKILQ 319
Cdd:smart00385   1 DFLRRVCKALNLDPETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLASKTEE 54
CYCLIN_CCNC_rpt1 cd20513
first cyclin box found in cyclin-C (CCNC) and similar proteins; CCNC, also termed CycC, or ...
 208-252 5.52e-03

first cyclin box found in cyclin-C (CCNC) and similar proteins; CCNC, also termed CycC, or SRB11, is a component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. It mediates stress-induced mitochondrial fission and apoptosis. CCNC contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410217 [Multi-domain]  Cd Length: 101  Bit Score: 36.03  E-value: 5.52e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 113678710 208 LLGVVCLFLAAKREECLLP------EVSELC--YLMENAYSKKQLLRMERRVL 252
Cdd:cd20513   46 LVAPTCLYLASKVEECPSHarlivaEAKVLKtkFSYEFPYRVNDILECEFYLL 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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