Forkhead (FH) domain found in Forkhead box (FOX) family of transcription factors and similar proteins; The FOX family comprises diverse tissue- and cell type-specific transcription factors with an evolutionary conserved "Forkhead (FH)" or "winged helix" DNA-binding domain. FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. The structure of the FH domain contains 2 flexible loops or "wings" in the C-terminal region, hence the term winged helix. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'. They participate in a variety of cellular processes, such as cell cycle progression, proliferation, differentiation, migration, metabolism, and DNA damage response. Their expression can be regulated by multiple factors, and they can act as co-activators and/or transcriptional repressors. Fifty FOX-encoding genes in humans have been categorized into 19 subfamilies based on protein sequence homology (FOXA to FOXS).

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 113678624  31 TYTGLIAYAIQESPDKKLTFKEIMTKLE---PFVFGEKRSIENNIRVCLSSNKCFVKVPVDPDYPNPKKNYWKVD 102
Cdd:cd20034    5 SYIALIAMAIRDSPSGRLTLAEINEYLMkkfPFFRGSYTGWRNSVRHNLSLNDCFVKVLRDPSRPWGKDNYWTIN 79

Forkhead (FH) domain found in Forkhead box protein Q1 (FOXQ1) and similar proteins; FOXQ1, also called HNF-3/Forkhead-like protein 1 (HFH-1), or hepatocyte nuclear factor 3 Forkhead homolog 1, plays a role in hair follicle differentiation. It has also been reported to promote epithelial differentiation, inhibit smooth muscle differentiation, activate T cells and autoimmunity, and control mucin gene expression and granule content in stomach surface mucous cells. FOXQ1 is significantly associated with the pathogenesis of various tumor types including gastric, breast, colorectal, pancreatic, bladder and ovarian cancer, and glioma. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 113678624  31 TYTGLIAYAIQESPDKKLTFKEIMTKLE---PFVFGEKRSIENNIRVCLSSNKCFVKVPVDPDYPNPKKNYWKVD 102
Cdd:cd20034    5 SYIALIAMAIRDSPSGRLTLAEINEYLMkkfPFFRGSYTGWRNSVRHNLSLNDCFVKVLRDPSRPWGKDNYWTIN 79

Forkhead domain;

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 113678624   31 TYTGLIAYAIQESPDKKLTFKEI---MTKLEPFVFGEKRSIENNIRVCLSSNKCFVKVPVDPDYPnPKKNYWKVDE 103
Cdd:pfam00250   5 SYAALIAMAILSSPEKKLTLSEIyewISENFPYYRTADKGWQNSIRHNLSLNKCFVKVPRPKDEP-GKGSYWTIDP 79

Forkhead (FH) domain found in Forkhead box protein Q1 (FOXQ1) and similar proteins; FOXQ1, also called HNF-3/Forkhead-like protein 1 (HFH-1), or hepatocyte nuclear factor 3 Forkhead homolog 1, plays a role in hair follicle differentiation. It has also been reported to promote epithelial differentiation, inhibit smooth muscle differentiation, activate T cells and autoimmunity, and control mucin gene expression and granule content in stomach surface mucous cells. FOXQ1 is significantly associated with the pathogenesis of various tumor types including gastric, breast, colorectal, pancreatic, bladder and ovarian cancer, and glioma. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 113678624  31 TYTGLIAYAIQESPDKKLTFKEIMTKLE---PFVFGEKRSIENNIRVCLSSNKCFVKVPVDPDYPNPKKNYWKVD 102
Cdd:cd20034    5 SYIALIAMAIRDSPSGRLTLAEINEYLMkkfPFFRGSYTGWRNSVRHNLSLNDCFVKVLRDPSRPWGKDNYWTIN 79

FORKHEAD; FORKHEAD, also known as a "winged helix"

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 113678624    32 YTGLIAYAIQESPDKKLTFKEI---MTKLEPFVFGEKRSIENNIRVCLSSNKCFVKVPVDPDYPNpKKNYWKVD 102
Cdd:smart00339   6 YIALIAMAILSSPDKRLTLSEIykwIEDNFPYYRENRAGWQNSIRHNLSLNDCFVKVPREGDRPG-KGSYWTLD 78

Forkhead (FH) domain found in the Forkhead box protein G (FOXG) subfamily; The FOXG subfamily includes a winged helix transcription factor FOXG1, which is also called brain factor 1 (BF-1), brain factor 2 (BF-2), Forkhead box protein G1A, Forkhead box protein G1B, Forkhead box protein G1C, Forkhead-related protein FKHL1, Forkhead-related protein FKHL2, or Forkhead-related protein FKHL3. FOXG1 acts as a transcription repression factor which plays an important role in the establishment of the regional subdivision of the developing brain and in the development of the telencephalon. It is repetitively used in the sequential events of telencephalic development to control multi-steps of brain circuit formation ranging from cell cycle control to neuronal differentiation in a clade- and species-specific manner. Individuals with mutations in FOXG1 harbor "FOXG1-related encephalopathy", characterized by two clinical phenotypes/syndromes including microcephaly, developmental delay, severe cognitive disabilities, early-onset dyskinesia and hyperkinetic movements, stereotypies, epilepsy, and cerebral malformation for those with deletions or intragenic mutations of FOXG1. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 113678624  31 TYTGLIAYAIQESPDKKLTFKEI---MTKLEPFVFGEKRSIENNIRVCLSSNKCFVKVPVDPDYPNpKKNYWKVD 102
Cdd:cd20021    5 SYNALIMMAIRQSPEKRLTLNGIyefIMKNFPYYRENKQGWQNSIRHNLSLNKCFVKVPRHYDDPG-KGNYWMLD 78

Forkhead (FH) domain found in Forkhead box (FOX) family of transcription factors and similar proteins; The FOX family comprises diverse tissue- and cell type-specific transcription factors with an evolutionary conserved "Forkhead (FH)" or "winged helix" DNA-binding domain. FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. The structure of the FH domain contains 2 flexible loops or "wings" in the C-terminal region, hence the term winged helix. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'. They participate in a variety of cellular processes, such as cell cycle progression, proliferation, differentiation, migration, metabolism, and DNA damage response. Their expression can be regulated by multiple factors, and they can act as co-activators and/or transcriptional repressors. Fifty FOX-encoding genes in humans have been categorized into 19 subfamilies based on protein sequence homology (FOXA to FOXS).

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 113678624  31 TYTGLIAYAIQESPDKKLTFKEI---MTKLEPFVFGEKRSIENNIRVCLSSNKCFVKVPVDPDYPNpKKNYW 99
Cdd:cd00059    4 SYAALIALAILSSPDKRLTLSEIykwIEDNFPYYRTATKGWKNSIRHNLSLNKCFVKVPREPSDPG-KGSYW 74

Forkhead (FH) domain found in the Forkhead box protein F (FOXF) subfamily; The FOXF subfamily includes two winged helix transcription factors, FOXF1 and FOXF2, both of which are probable transcription activators for a number of lung-specific genes. FOXF1 mutations in sporadic and familial cases of alveolar capillary dysplasia with misaligned pulmonary veins (ACD/MPV) suggest its involvement in ACD/MPV and lung organogenesis. FOXF2 is involved in programming organogenesis and regulating epithelial-to-mesenchymal transition (EMT) and cell proliferation. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 113678624  31 TYTGLIAYAIQESPDKKLTFKEIMTKLE---PFVFGEKRSIENNIRVCLSSNKCFVKVPVDPDYPNpKKNYWKVDE 103
Cdd:cd20020    4 SYIALIVMAIQASPTKRLTLSEIYQFLQqrfPFFRGPYQGWKNSVRHNLSLNECFIKLPKGLGRPG-KGHYWTIDP 78

Forkhead (FH) domain found in Forkhead box protein L2 (FOXL2) and similar proteins; FOXL2 is a transcriptional regulator that is essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination. Mutations in the FOXL2 gene cause blepharophimosis-ptosis-epicanthus inversus syndrome (BPES) types I and II, a rare genetic disorder. In BPES type I, a complex eyelid malformation is associated with premature ovarian failure (POF), whereas in BPES type II, the eyelid defect occurs as an isolated entity. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 113678624  31 TYTGLIAYAIQESPDKKLTFKEI----MTKLePFVFGEKRSIENNIRVCLSSNKCFVKVPVDPDyPNPKKNYWKVDEN 104
Cdd:cd20028    5 SYVALIAMAIRESPEKRLTLSGIyqyiIAKF-PYYEKNKKGWQNSIRHNLSLNECFVKVPREGG-GERKGNYWTLDPA 80

Forkhead (FH) domain found in the Forkhead box protein C (FOXC) subfamily; The FOXC subfamily includes two winged helix transcription factors, FOXC1 (also called Forkhead-related protein FKHL7, or Forkhead-related transcription factor 3) and FOXC2 (also called Forkhead-related protein FKHL14, or Mesenchyme fork head protein 1). FOXC1 is a DNA-binding transcriptional factor that plays a role in a broad range of cellular and developmental processes such as the development of the eyes, bones, cardiovascular system, kidneys, and skin. FOXC2 acts as a transcriptional activator that might be involved in the formation of special mesenchymal tissues. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 113678624  31 TYTGLIAYAIQESPDKKLT----FKEIMTKLePFVFGEKRSIENNIRVCLSSNKCFVKVPVDPDYPNpKKNYW 99
Cdd:cd20017    5 SYIALIAMAIQNAPDKKITlngiYQFIMDRF-PFYRENKQGWQNSIRHNLSLNECFVKVPRDDKKPG-KGSYW 75

Forkhead (FH) domain found in the Forkhead box protein A (FOXA) subfamily; The FOXA subfamily includes three winged helix transcription factors, FOXA1 (also called hepatocyte nuclear factor 3-alpha or transcription factor 3A), FOXA2 (also called hepatocyte nuclear factor 3-beta or transcription factor 3B), and FOXA3 (also called hepatocyte nuclear factor 3-gamma or transcription factor 3G). FOXA1 is essential for epithelial lineage differentiation and has been found to be upregulated in numerous cancers. FOXA2 controls cell differentiation. It is a key transcriptional regulator that maintains airway mucus homeostasis and may also have an important role in bone metabolism. FOXA3 acts as an essential transcriptional regulator engaged in adipogenesis and energy metabolism. This subfamily also includes Xenopus tropicalis FOXA4, Drosophila melanogaster protein fork head (dFKH), and similar proteins. FOXA4 is only present in amphibians, where it is required for the correct regionalization and maintenance of the central nervous system. dFKH promotes terminal as opposed to segmental development. In the absence of dFKH, this developmental switch does not occur. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 113678624  31 TYTGLIAYAIQESPDKKLTFKEI---MTKLEPFVFGEKRSIENNIRVCLSSNKCFVKVPVDPDYPNpKKNYW 99
Cdd:cd20015    5 SYISLITMAIQQSPSKMLTLSEIyqwIMDLFPYYRQNQQRWQNSIRHSLSFNDCFVKVPRSPDKPG-KGSYW 75

Forkhead (FH) domain found in Forkhead box protein C2 (FOXC2) and similar proteins; FOXC2, also called Forkhead-related protein FKHL14, Mesenchyme fork head protein 1 (MFH-1 protein), or transcription factor FKH-14, acts as a transcriptional activator that might be involved in the formation of special mesenchymal tissues. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 113678624  31 TYTGLIAYAIQESPDKKLT----FKEIMTKLePFVFGEKRSIENNIRVCLSSNKCFVKVPVDPDYPNpKKNYWKVDEN 104
Cdd:cd20045    7 SYIALITMAIQNAPDKKITlngiYQFIMDRF-PFYRENKQGWQNSIRHNLSLNECFVKVPRDDKKPG-KGSYWTLDPD 82

Forkhead (FH) domain found in Forkhead box proteins, FOXJ2, FOXJ3 and similar proteins; The FOXJ2-like subfamily includes two winged helix transcription factors, FOXJ2 and FOXJ3. FOXJ2, also called Forkhead homologous X (FHX), plays an important role in tumorigenesis, progression, and metastasis of certain cancers. It acts as a transcriptional activator that can bind to two different type of DNA binding sites. FOXJ3 is a transcription factor which regulates sperm function. It transcriptionally activates Mef2c and regulates adult skeletal muscle fiber type identity. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 113678624  31 TYTGLIAYAIQESPDKKLTFKEIMTKLE---PFVFGEKRSIENNIRVCLSSNKCFVKVPVDPDYPNpKKNYWKV 101
Cdd:cd20024    5 SYATLITFAINSSPKKKMTLSEIYTWICenfPYYREAGTGWKNSIRHNLSLNKCFKKVPRSKDDPG-KGSYWTL 77

Forkhead (FH) domain found in Drosophila melanogaster protein fork head (dFKH) and similar proteins; dFKH promotes terminal as opposed to segmental development. In the absence of dFKH, this developmental switch does not occur. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 113678624  31 TYTGLIAYAIQESPDKKLTFKEI---MTKLEPFVFGEKRSIENNIRVCLSSNKCFVKVPVDPDYPNpKKNYW 99
Cdd:cd20041    5 SYISLITMAIQNSPNKMVTLSEIyqfIMDLFPFYRQNQQRWQNSIRHSLSFNDCFVKVPRTPDKPG-KGSFW 75

Forkhead (FH) domain found in Forkhead box protein F2 (FOXF2) and similar proteins; FOXF2, also called Forkhead-related activator 2 (FREAC-2), Forkhead-related protein FKHL6, or Forkhead-related transcription factor 2, is a probable transcription activator for a number of lung-specific genes. It is involved in programming organogenesis and regulating epithelial-to-mesenchymal transition (EMT) and cell proliferation. FOXF2 dysregulation is critical for tumorigenesis of various tissue types. Its expression correlates with good prognosis in patients with early non-invasive stages of breast cancer, but with poor prognosis in advanced breast cancer. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 113678624  31 TYTGLIAYAIQESPDKKLTFKEIMTKLE---PFVFGEKRSIENNIRVCLSSNKCFVKVPVDPDYPNpKKNYWKVD 102
Cdd:cd20050    4 SYIALIVMAIQSSPSKKLTLSEIYQFLQarfPFFRGAYQGWKNSVRHNLSLNECFIKLPKGLGRPG-KGHYWTID 77

Forkhead (FH) domain found in Forkhead box protein F1 (FOXF1) and similar proteins; FOXF1, also called Forkhead-related activator 1 (FREAC-1), Forkhead-related protein FKHL5, or Forkhead-related transcription factor 1, is a probable transcription activator for a number of lung-specific genes. FOXF1 mutations in sporadic and familial cases of alveolar capillary dysplasia with misaligned pulmonary veins (ACD/MPV) suggest its involvement in ACD/MPV and lung organogenesis. The role of FOXF1 in cancer is conflicting; its loss in some cancers suggests a tumor suppressive function, but its abundance in others is associated with protumorigenic and metastatic traits. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 113678624  31 TYTGLIAYAIQESPDKKLTFKEIMTKLE---PFVFGEKRSIENNIRVCLSSNKCFVKVPVDPDYPNpKKNYWKVD 102
Cdd:cd20049    4 SYIALIVMAIQSSPTKRLTLSEIYQFLQsrfPFFRGSYQGWKNSVRHNLSLNECFIKLPKGLGRPG-KGHYWTID 77

Forkhead (FH) domain found in Forkhead box protein S1 (FOXS1); FOXS1, also called Forkhead-like 18 protein or Forkhead-related transcription factor 10 (FREAC-10), is a transcriptional repressor that suppresses transcription from the FASLG, FOXO3, and FOXO4 promoters. It may have a role in the organization of the testicular vasculature. It has also been implicated in energy turnover, motor function, and body weight. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 113678624  31 TYTGLIAYAIQESPDKKLT----FKEIMTKLEpFVFGEKRSIENNIRVCLSSNKCFVKVPVDPDYPNpKKNYWKVD 102
Cdd:cd20037    6 SYIALIAMAIQSSPGQRATlsgiYRYIMGRFA-FYRHNRPGWQNSIRHNLSLNECFVKVPRDDRKPG-KGSYWTLD 79

Forkhead (FH) domain found in Forkhead box protein D4 (FOXD4) and similar proteins; FOXD4, also called Forkhead-related protein FKHL9, Forkhead-related transcription factor 5 (FREAC-5), or myeloid factor-alpha, is essential for establishing neural cell fate and for neuronal differentiation. The family also includes Forkhead box protein D4-like proteins, FOXD4L1-6. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 113678624  31 TYTGLIAYAIQESPDKKLTFKEIMTKLEP-FVFGEKR--SIENNIRVCLSSNKCFVKVPVDPDYPNpKKNYWKVDEN 104
Cdd:cd20048    5 SYIALITMAILQSPHKRLTLSGICAFISGrFPYYRRKfpAWQNSIRHNLSLNDCFVKIPREPGHPG-KGNYWSLDPA 80

Forkhead (FH) domain found in Forkhead box protein A1 (FOXA1) and similar proteins; FOXA1, also called hepatocyte nuclear factor 3-alpha (HNF-3-alpha or HNF-3A) or transcription factor 3A (TCF-3A), acts as a transcription factor that is essential for epithelial lineage differentiation. It has been found to be upregulated in numerous cancers. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 113678624  31 TYTGLIAYAIQESPDKKLTFKEI---MTKLEPFVFGEKRSIENNIRVCLSSNKCFVKVPVDPDYPNpKKNYWKV 101
Cdd:cd20038   18 SYISLITMAIQQAPSKMLTLSEIyqwIMDLFPYYRQNQQRWQNSIRHSLSFNDCFVKVARSPDKPG-KGSYWTL 90

Forkhead (FH) domain found in Forkhead box protein J1 (FOXJ1) and similar proteins; FOXJ1, also called Forkhead-related protein FKHL13 or hepatocyte nuclear factor 3 Forkhead homolog 4 (HFH-4), acts as a transcription factor specifically required for the formation of motile cilia. It acts by activating transcription of genes that mediate assembly of motile cilia, such as CFAP157. FOXJ1 binds the DNA consensus sequences 5'-HWDTGTTTGTTTA-3' or 5'-KTTTGTTGTTKTW-3' (where H is not G, W is A or T, D is not C, and K is G or T). It activates the transcription of a variety of ciliary proteins in the developing brain and lung. The FH domain is a winged helix DNA-binding domain.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 113678624  31 TYTGLIAYAIQESPDKKLTFKEIMTKL-EPFVFGE--KRSIENNIRVCLSSNKCFVKVPVDPDYPNpKKNYWKVD 102
Cdd:cd20023    5 SYATLICMAMQASKKTKITLSAIYKWItDNFMYYRvaDPTWQNSIRHNLSLNKCFIKVPRSKDEPG-KGGFWRID 78

Forkhead (FH) domain found in the Forkhead box protein P (FOXP) subfamily; The FOXP subfamily includes four winged helix transcription factors, FOXP1-4. They are involved in the development of the central nervous system. Mutations in FOXP1, also called Mac-1-regulated Forkhead (MFH), leads to developmental delay, intellectual disability, autism spectrum disorder, speech delay, and dysmorphic features. FOXP2, also called CAG repeat protein 44 or Trinucleotide repeat-containing gene 10 protein, is a transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. It may also play a role in developing neural, gastrointestinal and cardiovascular tissues. FOXP3, also called Scurfin, is a transcriptional regulator which is crucial for the development and inhibitory function of regulatory T-cells (Treg). FOXP4, also called Forkhead-related protein-like A, is a transcriptional repressor that represses lung-specific expression. It is necessary for normal T cell cytokine recall responses to antigen following pathogenic infection. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 113678624  31 TYTGLIAYAIQESPDKKLTFKEI---MTKLEPFVFGEKRSIENNIRVCLSSNKCFVKV 85
Cdd:cd20033    5 TYASLIRQAILESPNKQLTLNEIynwFQKTFAYFRRNAATWKNAVRHNLSLHKCFVRV 62

Forkhead (FH) domain found in Forkhead box protein N2 (FOXN2); FOXN2, also called human T-cell leukemia virus enhancer factor (HTLF), is a potential tumor suppressor that can facilitate replication fork reversal. It acts as a transcription factor that binds to the purine-rich region in human T-cell leukemia virus long terminal repeat (HTLV-I LTR). It may be a potential therapeutic and radiosensitization target for lung cancer. FOXN2 has also been found to be down-regulated in breast cancer, where it regulates migration, invasion, and epithelial-mesenchymal transition. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 113678624  31 TYTGLIAYAIQESPDKKLTFKEI---MTKLEPFVFGEKRSIENNIRVCLSSNKCFVKVPVDPDYPNPKKNYWKVD 102
Cdd:cd20058    6 SFSLLIYMAIEHSPNKCLPVKEIyswILEHFPYFSTAPTGWKNSVRHNLSLNKCFRKVERSHGKVNGKGSLWCVD 80