Stealth protein CR2, conserved region 2; Stealth_CR2 is the second of several highly conserved regions on stealth proteins in metazoa and bacteria. There are up to four CR regions on all member proteins. CR2 carries a well-conserved NDD sequence-motif. The domain is found in tandem with CR1, CR3 and CR4 on both potential metazoan hosts and pathogenic eubacterial species that are capsular polysaccharide phosphotransferases. The CR domains appear on eukaryotic proteins such as GNPTAB, N-acetylglucosamine-1-phosphotransferase subunits alpha/beta. Horizontal gene-transfer seems to have occurred between host and bacteria of these sequence-regions in order for the bacteria to evade detection by the host innate immune system.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113677215   327 RFEDNEELRYSLRSIEKHAPWVRHIFIVTNGQIPSWLNLDNPRVSVVTHQDIFQNQTHLPTFSSPAIETHIHRIPGLSQK 406
Cdd:pfam11380    1 RFRDRDELRYSLRSVEKYAPWVRKIYIVTDGQIPSWLNTSHPKIRIVDHKDIFPNESHLPTFNSHAIESNLHRIPGLSEH 80

                           90       100
                   ....*....|....*....|....*...
gi 113677215   407 FIYLNDDVMFGKDVWPDDFYSHSKGQKV 434
Cdd:pfam11380   81 FLYFNDDMFLGRPVKPEDFFTPDGLPKD 108

Putative GlcNAc-1 phosphotransferase regulatory domain; The Golgi enzyme UDP-GlcNAc-lysosomal enzyme N-acetylglucosamine-1-phosphotransferase (GlcNAc-1-phosphotransferase), an alpha2beta2gamma2 hexamer, mediates the initial step in the addition of the mannose 6-phosphate targeting signal on newly synthesized lysosomal enzymes. GNPTAB encodes the alpha and beta subunits of GlcNAc-1-phosphotransferase, and mutations in this gene cause the lysosomal storage disorders mucolipidosis II and III alpha-beta The alpha-beta subunits contain three identifiable domains separated by so-called spacer regions. This domain is part of the first spacer region, Spacer-1. Studies indicate that GlcNAc-1 lacking spacer-1 exhibits enhanced phosphorylation of several non-lysosomal glycoproteins, while the phosphorylation of lysosomal acid hydrolases is not altered. In view of these effects on the maturation and function of GlcNAc-1, it is suggested to rename 'spacer-1' the 'regulatory-1' domain.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113677215   224 PGLVRMHTLAYLSGFPASLKETEQLRVKLPAVVTSKTKKLQLYSEASIALLHLNTAQDFTDLTQQAKKNLTLDGKELTVS 303
Cdd:pfam18440    2 PGLVLMQDLAFLSGFPRTFKETNQLKTKLPEKLRSKVKLLQLYSEASVALLDLNNPKDFDELLKQGKKNMTIDGKELTLT 81

                   ....*..
gi 113677215   304 SAFLFWD 310
Cdd:pfam18440   82 PAYLLWD 88

Stealth protein CR3, conserved region 3; Stealth_CR3 is the third of several highly conserved regions on stealth proteins in metazoa and bacteria. There are up to four CR regions on all member proteins. The domain is found in tandem with CR1, CR2 and CR4 on both potential metazoan hosts and pathogenic eubacterial species that are capsular polysaccharide phosphotransferases. The CR domains appear on eukaryotic proteins such as GNPTAB, N-acetylglucosamine-1-phosphotransferase subunits alpha/beta. Horizontal gene-transfer seems to have occurred between host and bacteria of these sequence-regions in order for the bacteria to evade detection by the host innate immune system.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 113677215   920 AHMPHMIDRLIMQELQDTFPQEFDKTSSHRVRHSEDMQFAFSYFYFLMS 968
Cdd:pfam17102    1 AHTPHPLRRSVLEEIEERFPEEFARTASHRFRSPDDLSMAFSYHHYYAE 49

Stealth protein CR1, conserved region 1; Stealth_C1 is the first of several highly conserved regions on stealth proteins in metazoa and bacteria. There are up to four CR regions on all member proteins. CR1 carries a well-conserved IDVVYT sequence-motif. The domain is found in tandem with CR2, CR3 and CR4 on both potential metazoan hosts and pathogenic eubacterial species that are capsular polysaccharide phosphotransferases. The CR domains appear on eukaryotic proteins such as GNPTAB, N-acetylglucosamine-1-phosphotransferase subunits alpha/beta. Horizontal gene-transfer seems to have occurred between host and bacteria of these sequence-regions in order for the bacteria to evade detection by the host innate immune system.

                           10        20
                   ....*....|....*....|....*....
gi 113677215    78 MPIDVVYTWVNGTDINLLKDLRAVRQRLE 106
Cdd:pfam17101    1 FPIDVVYTWVNGSDPEWQAKKAKYLGKLG 29

DMAP1-binding Domain; This domain binds DMAP1, a transcriptional co-repressor.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113677215   696 NETLLPDEVKIELKKLNEKLMSGDITIKGFNLTKAMLLEPYKEKDQFTLKHEKDKEEKQKLSPvAQLQNERAAARVKREK 775
Cdd:pfam06464    1 NPPSLPDDVRERLSELDLDLSEGDITEKGYEKKKLKLLRKFLLHPETPTKLSAEAQNQLASLE-TKLRDEELSEEVYLEK 79

Stealth protein CR2, conserved region 2; Stealth_CR2 is the second of several highly conserved regions on stealth proteins in metazoa and bacteria. There are up to four CR regions on all member proteins. CR2 carries a well-conserved NDD sequence-motif. The domain is found in tandem with CR1, CR3 and CR4 on both potential metazoan hosts and pathogenic eubacterial species that are capsular polysaccharide phosphotransferases. The CR domains appear on eukaryotic proteins such as GNPTAB, N-acetylglucosamine-1-phosphotransferase subunits alpha/beta. Horizontal gene-transfer seems to have occurred between host and bacteria of these sequence-regions in order for the bacteria to evade detection by the host innate immune system.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113677215   327 RFEDNEELRYSLRSIEKHAPWVRHIFIVTNGQIPSWLNLDNPRVSVVTHQDIFQNQTHLPTFSSPAIETHIHRIPGLSQK 406
Cdd:pfam11380    1 RFRDRDELRYSLRSVEKYAPWVRKIYIVTDGQIPSWLNTSHPKIRIVDHKDIFPNESHLPTFNSHAIESNLHRIPGLSEH 80

                           90       100
                   ....*....|....*....|....*...
gi 113677215   407 FIYLNDDVMFGKDVWPDDFYSHSKGQKV 434
Cdd:pfam11380   81 FLYFNDDMFLGRPVKPEDFFTPDGLPKD 108

Putative GlcNAc-1 phosphotransferase regulatory domain; The Golgi enzyme UDP-GlcNAc-lysosomal enzyme N-acetylglucosamine-1-phosphotransferase (GlcNAc-1-phosphotransferase), an alpha2beta2gamma2 hexamer, mediates the initial step in the addition of the mannose 6-phosphate targeting signal on newly synthesized lysosomal enzymes. GNPTAB encodes the alpha and beta subunits of GlcNAc-1-phosphotransferase, and mutations in this gene cause the lysosomal storage disorders mucolipidosis II and III alpha-beta The alpha-beta subunits contain three identifiable domains separated by so-called spacer regions. This domain is part of the first spacer region, Spacer-1. Studies indicate that GlcNAc-1 lacking spacer-1 exhibits enhanced phosphorylation of several non-lysosomal glycoproteins, while the phosphorylation of lysosomal acid hydrolases is not altered. In view of these effects on the maturation and function of GlcNAc-1, it is suggested to rename 'spacer-1' the 'regulatory-1' domain.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113677215   224 PGLVRMHTLAYLSGFPASLKETEQLRVKLPAVVTSKTKKLQLYSEASIALLHLNTAQDFTDLTQQAKKNLTLDGKELTVS 303
Cdd:pfam18440    2 PGLVLMQDLAFLSGFPRTFKETNQLKTKLPEKLRSKVKLLQLYSEASVALLDLNNPKDFDELLKQGKKNMTIDGKELTLT 81

                   ....*..
gi 113677215   304 SAFLFWD 310
Cdd:pfam18440   82 PAYLLWD 88

Stealth protein CR4, conserved region 4; Stealth_CR4 is the fourth highly conserved region on stealth proteins in metazoa and bacteria. There are four CR regions on mammalian members. CR4 carries a well-conserved CLND sequence-motif. The domain is found in tandem with CR1, CR2 and CR3 on both potential metazoan hosts and on pathogenic eubacterial species that are capsular polysaccharide phosphotransferases. The CR domains also appear on eukaryotic proteins such as GNPTAB, N-acetylglucosamine-1-phosphotransferase subunits alpha/beta. Horizontal gene-transfer seems to have occurred between host and bacteria of these sequence-regions in order for the bacteria to evade detection by the host innate immune system.

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 113677215  1103 DDIRKNPRKFICLNDNIDHIHKDAgtVKAVLRDFYESMFPLPSQFELPREYRNRFLH 1159
Cdd:pfam17103    1 DGIRRRRKKFFCLNDNIDPEVEEE--VKALLQDFLESLFPFPSPFELPPAYRNRFLY 55

LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase.

                           10        20        30
                   ....*....|....*....|....*....|....*
gi 113677215   441 PNC-AEGCPgSWIKDGYCDKACNNSACDWDGGDCQ 474
Cdd:pfam00066    2 PNCpYPYCW-DKFGNGVCDEECNNAECLWDGGDCS 35

Stealth protein CR1, conserved region 1; Stealth_C1 is the first of several highly conserved regions on stealth proteins in metazoa and bacteria. There are up to four CR regions on all member proteins. CR1 carries a well-conserved IDVVYT sequence-motif. The domain is found in tandem with CR2, CR3 and CR4 on both potential metazoan hosts and pathogenic eubacterial species that are capsular polysaccharide phosphotransferases. The CR domains appear on eukaryotic proteins such as GNPTAB, N-acetylglucosamine-1-phosphotransferase subunits alpha/beta. Horizontal gene-transfer seems to have occurred between host and bacteria of these sequence-regions in order for the bacteria to evade detection by the host innate immune system.

                           10        20
                   ....*....|....*....|....*....
gi 113677215    78 MPIDVVYTWVNGTDINLLKDLRAVRQRLE 106
Cdd:pfam17101    1 FPIDVVYTWVNGSDPEWQAKKAKYLGKLG 29

DMAP1-binding Domain; This domain binds DMAP1, a transcriptional co-repressor.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113677215   696 NETLLPDEVKIELKKLNEKLMSGDITIKGFNLTKAMLLEPYKEKDQFTLKHEKDKEEKQKLSPvAQLQNERAAARVKREK 775
Cdd:pfam06464    1 NPPSLPDDVRERLSELDLDLSEGDITEKGYEKKKLKLLRKFLLHPETPTKLSAEAQNQLASLE-TKLRDEELSEEVYLEK 79

Stealth protein CR2, conserved region 2; Stealth_CR2 is the second of several highly conserved regions on stealth proteins in metazoa and bacteria. There are up to four CR regions on all member proteins. CR2 carries a well-conserved NDD sequence-motif. The domain is found in tandem with CR1, CR3 and CR4 on both potential metazoan hosts and pathogenic eubacterial species that are capsular polysaccharide phosphotransferases. The CR domains appear on eukaryotic proteins such as GNPTAB, N-acetylglucosamine-1-phosphotransferase subunits alpha/beta. Horizontal gene-transfer seems to have occurred between host and bacteria of these sequence-regions in order for the bacteria to evade detection by the host innate immune system.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113677215   327 RFEDNEELRYSLRSIEKHAPWVRHIFIVTNGQIPSWLNLDNPRVSVVTHQDIFQNQTHLPTFSSPAIETHIHRIPGLSQK 406
Cdd:pfam11380    1 RFRDRDELRYSLRSVEKYAPWVRKIYIVTDGQIPSWLNTSHPKIRIVDHKDIFPNESHLPTFNSHAIESNLHRIPGLSEH 80

                           90       100
                   ....*....|....*....|....*...
gi 113677215   407 FIYLNDDVMFGKDVWPDDFYSHSKGQKV 434
Cdd:pfam11380   81 FLYFNDDMFLGRPVKPEDFFTPDGLPKD 108

Putative GlcNAc-1 phosphotransferase regulatory domain; The Golgi enzyme UDP-GlcNAc-lysosomal enzyme N-acetylglucosamine-1-phosphotransferase (GlcNAc-1-phosphotransferase), an alpha2beta2gamma2 hexamer, mediates the initial step in the addition of the mannose 6-phosphate targeting signal on newly synthesized lysosomal enzymes. GNPTAB encodes the alpha and beta subunits of GlcNAc-1-phosphotransferase, and mutations in this gene cause the lysosomal storage disorders mucolipidosis II and III alpha-beta The alpha-beta subunits contain three identifiable domains separated by so-called spacer regions. This domain is part of the first spacer region, Spacer-1. Studies indicate that GlcNAc-1 lacking spacer-1 exhibits enhanced phosphorylation of several non-lysosomal glycoproteins, while the phosphorylation of lysosomal acid hydrolases is not altered. In view of these effects on the maturation and function of GlcNAc-1, it is suggested to rename 'spacer-1' the 'regulatory-1' domain.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113677215   224 PGLVRMHTLAYLSGFPASLKETEQLRVKLPAVVTSKTKKLQLYSEASIALLHLNTAQDFTDLTQQAKKNLTLDGKELTVS 303
Cdd:pfam18440    2 PGLVLMQDLAFLSGFPRTFKETNQLKTKLPEKLRSKVKLLQLYSEASVALLDLNNPKDFDELLKQGKKNMTIDGKELTLT 81

                   ....*..
gi 113677215   304 SAFLFWD 310
Cdd:pfam18440   82 PAYLLWD 88

Stealth protein CR4, conserved region 4; Stealth_CR4 is the fourth highly conserved region on stealth proteins in metazoa and bacteria. There are four CR regions on mammalian members. CR4 carries a well-conserved CLND sequence-motif. The domain is found in tandem with CR1, CR2 and CR3 on both potential metazoan hosts and on pathogenic eubacterial species that are capsular polysaccharide phosphotransferases. The CR domains also appear on eukaryotic proteins such as GNPTAB, N-acetylglucosamine-1-phosphotransferase subunits alpha/beta. Horizontal gene-transfer seems to have occurred between host and bacteria of these sequence-regions in order for the bacteria to evade detection by the host innate immune system.

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 113677215  1103 DDIRKNPRKFICLNDNIDHIHKDAgtVKAVLRDFYESMFPLPSQFELPREYRNRFLH 1159
Cdd:pfam17103    1 DGIRRRRKKFFCLNDNIDPEVEEE--VKALLQDFLESLFPFPSPFELPPAYRNRFLY 55

LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase.

                           10        20        30
                   ....*....|....*....|....*....|....*
gi 113677215   441 PNC-AEGCPgSWIKDGYCDKACNNSACDWDGGDCQ 474
Cdd:pfam00066    2 PNCpYPYCW-DKFGNGVCDEECNNAECLWDGGDCS 35

Stealth protein CR1, conserved region 1; Stealth_C1 is the first of several highly conserved regions on stealth proteins in metazoa and bacteria. There are up to four CR regions on all member proteins. CR1 carries a well-conserved IDVVYT sequence-motif. The domain is found in tandem with CR2, CR3 and CR4 on both potential metazoan hosts and pathogenic eubacterial species that are capsular polysaccharide phosphotransferases. The CR domains appear on eukaryotic proteins such as GNPTAB, N-acetylglucosamine-1-phosphotransferase subunits alpha/beta. Horizontal gene-transfer seems to have occurred between host and bacteria of these sequence-regions in order for the bacteria to evade detection by the host innate immune system.

                           10        20
                   ....*....|....*....|....*....
gi 113677215    78 MPIDVVYTWVNGTDINLLKDLRAVRQRLE 106
Cdd:pfam17101    1 FPIDVVYTWVNGSDPEWQAKKAKYLGKLG 29

DMAP1-binding Domain; This domain binds DMAP1, a transcriptional co-repressor.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113677215   696 NETLLPDEVKIELKKLNEKLMSGDITIKGFNLTKAMLLEPYKEKDQFTLKHEKDKEEKQKLSPvAQLQNERAAARVKREK 775
Cdd:pfam06464    1 NPPSLPDDVRERLSELDLDLSEGDITEKGYEKKKLKLLRKFLLHPETPTKLSAEAQNQLASLE-TKLRDEELSEEVYLEK 79