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Conserved domains on  [gi|82654216|ref|NP_001032433|]
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p21-activated protein kinase-interacting protein 1 [Rattus norvegicus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
28-277 7.80e-37

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 137.74  E-value: 7.80e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654216  28 ETWTPVADFTHHAHTASLSAVAANNRYVVTGSKDETIHIYDMKKKVEHGALVHHSGTVTCLKFY-GSRHLISGAEDGLIC 106
Cdd:COG2319 150 ATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSpDGKLLASGSADGTVR 229

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654216 107 VWDAKKWECLKSIKAHRGHVTFLSIHPSGKLALSVGTDKTLRTWNLVEGRS-AFIKNIKQNAHIVEWSPNGEkyvvvvmn 185
Cdd:COG2319 230 LWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELlRTLTGHSGGVNSVAFSPDGK-------- 301

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654216 186 kvdvyHLDTASVSGT-----LTNGK----------RISAITFLSD-SVLAVAGDEEVVRFFDCDTLVCLCEFKAHENRVK 249
Cdd:COG2319 302 -----LLASGSDDGTvrlwdLATGKllrtltghtgAVRSVAFSPDgKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVT 376

                       250       260
                ....*....|....*....|....*...
gi 82654216 250 DmVSFeIPDHHVLVTASNDGFIKMWTLT 277
Cdd:COG2319 377 S-VAF-SPDGRTLASGSADGTVRLWDLA 402
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
28-277 7.80e-37

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 137.74  E-value: 7.80e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654216  28 ETWTPVADFTHHAHTASLSAVAANNRYVVTGSKDETIHIYDMKKKVEHGALVHHSGTVTCLKFY-GSRHLISGAEDGLIC 106
Cdd:COG2319 150 ATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSpDGKLLASGSADGTVR 229

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654216 107 VWDAKKWECLKSIKAHRGHVTFLSIHPSGKLALSVGTDKTLRTWNLVEGRS-AFIKNIKQNAHIVEWSPNGEkyvvvvmn 185
Cdd:COG2319 230 LWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELlRTLTGHSGGVNSVAFSPDGK-------- 301

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654216 186 kvdvyHLDTASVSGT-----LTNGK----------RISAITFLSD-SVLAVAGDEEVVRFFDCDTLVCLCEFKAHENRVK 249
Cdd:COG2319 302 -----LLASGSDDGTvrlwdLATGKllrtltghtgAVRSVAFSPDgKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVT 376

                       250       260
                ....*....|....*....|....*...
gi 82654216 250 DmVSFeIPDHHVLVTASNDGFIKMWTLT 277
Cdd:COG2319 377 S-VAF-SPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 41-274 2.19e-36

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 134.00  E-value: 2.19e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654216  41 HTASLSAVA--ANNRYVVTGSKDETIHIYDMKKKVEHGALVHHSGTVTCLKFYGSRHLISGA-EDGLICVWDAKKWECLK 117
Cdd:cd00200  50 HTGPVRDVAasADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSsRDKTIKVWDVETGKCLT 129

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654216 118 SIKAHRGHVTFLSIHPSGKLALSVGTDKTLRTWNLVEGRsaFIKNIKqnAHI-----VEWSPNGEKYVVVVM-NKVDVYH 191
Cdd:cd00200 130 TLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGK--CVATLT--GHTgevnsVAFSPDGEKLLSSSSdGTIKLWD 205

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654216 192 LDTASVSGTLT-NGKRISAITFLSDSVLAVAGDEE-VVRFFDCDTLVCLCEFKAHENRVKDMVSFeiPDHHVLVTASNDG 269
Cdd:cd00200 206 LSTGKCLGTLRgHENGVNSVAFSPDGYLLASGSEDgTIRVWDLRTGECVQTLSGHTNSVTSLAWS--PDGKRLASGSADG 283


                ....*
gi 82654216 270 FIKMW 274
Cdd:cd00200 284 TIRIW 288
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 112-151 9.42e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.30  E-value: 9.42e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 82654216    112 KWECLKSIKAHRGHVTFLSIHPSGKLALSVGTDKTLRTWN 151
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
113-151 2.08e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.18  E-value: 2.08e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 82654216   113 WECLKSIKAHRGHVTFLSIHPSGKLALSVGTDKTLRTWN 151
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 54-271 7.45e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 44.69  E-value: 7.45e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654216   54 YVVTGSKDETIHIYDMKKKVEHGALVHH-----------SGTvtCLKFYGSRHLISGAEDGLICVWDAKKWECLKSIKAH 122
Cdd:PLN00181 497 FFATAGVNKKIKIFECESIIKDGRDIHYpvvelasrsklSGI--CWNSYIKSQVASSNFEGVVQVWDVARSQLVTEMKEH 574

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654216  123 RGHVTFLSIHPSGKLALSVGTDK-TLRTWNLVEGRSafIKNIKQNAHI--VEWSPNGEKYVVVVMNKVDVYHLDTAS--- 196
Cdd:PLN00181 575 EKRVWSIDYSSADPTLLASGSDDgSVKLWSINQGVS--IGTIKTKANIccVQFPSESGRSLAFGSADHKVYYYDLRNpkl 652

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654216  197 -VSGTLTNGKRISAITFLSDSVLAVAGDEEVVRFFDCDTLVC------LCEFKAHENrVKDMVSFEIPDHHVLV-TASND 268
Cdd:PLN00181 653 pLCTMIGHSKTVSYVRFVDSSTLVSSSTDNTLKLWDLSMSISginetpLHSFMGHTN-VKNFVGLSVSDGYIATgSETNE 731


                 ...
gi 82654216  269 GFI 271
Cdd:PLN00181 732 VFV 734
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
28-277 7.80e-37

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 137.74  E-value: 7.80e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654216  28 ETWTPVADFTHHAHTASLSAVAANNRYVVTGSKDETIHIYDMKKKVEHGALVHHSGTVTCLKFY-GSRHLISGAEDGLIC 106
Cdd:COG2319 150 ATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSpDGKLLASGSADGTVR 229

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654216 107 VWDAKKWECLKSIKAHRGHVTFLSIHPSGKLALSVGTDKTLRTWNLVEGRS-AFIKNIKQNAHIVEWSPNGEkyvvvvmn 185
Cdd:COG2319 230 LWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELlRTLTGHSGGVNSVAFSPDGK-------- 301

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654216 186 kvdvyHLDTASVSGT-----LTNGK----------RISAITFLSD-SVLAVAGDEEVVRFFDCDTLVCLCEFKAHENRVK 249
Cdd:COG2319 302 -----LLASGSDDGTvrlwdLATGKllrtltghtgAVRSVAFSPDgKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVT 376

                       250       260
                ....*....|....*....|....*...
gi 82654216 250 DmVSFeIPDHHVLVTASNDGFIKMWTLT 277
Cdd:COG2319 377 S-VAF-SPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 41-274 2.19e-36

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 134.00  E-value: 2.19e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654216  41 HTASLSAVA--ANNRYVVTGSKDETIHIYDMKKKVEHGALVHHSGTVTCLKFYGSRHLISGA-EDGLICVWDAKKWECLK 117
Cdd:cd00200  50 HTGPVRDVAasADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSsRDKTIKVWDVETGKCLT 129

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654216 118 SIKAHRGHVTFLSIHPSGKLALSVGTDKTLRTWNLVEGRsaFIKNIKqnAHI-----VEWSPNGEKYVVVVM-NKVDVYH 191
Cdd:cd00200 130 TLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGK--CVATLT--GHTgevnsVAFSPDGEKLLSSSSdGTIKLWD 205

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654216 192 LDTASVSGTLT-NGKRISAITFLSDSVLAVAGDEE-VVRFFDCDTLVCLCEFKAHENRVKDMVSFeiPDHHVLVTASNDG 269
Cdd:cd00200 206 LSTGKCLGTLRgHENGVNSVAFSPDGYLLASGSEDgTIRVWDLRTGECVQTLSGHTNSVTSLAWS--PDGKRLASGSADG 283


                ....*
gi 82654216 270 FIKMW 274
Cdd:cd00200 284 TIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
27-276 2.66e-32

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 125.41  E-value: 2.66e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654216  27 RETWTPVADFTHHAHTASLSAVAANNRYVVTGSKDETIHIYDMKKKVEHGALVHHSGTVTCLKFygS---RHLISGAEDG 103
Cdd:COG2319  65 AAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAF--SpdgKTLASGSADG 142

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654216 104 LICVWDAKKWECLKSIKAHRGHVTFLSIHPSGKLALSVGTDKTLRTWNLVEGRSAFIKNIKQNA-HIVEWSPNGEkyvvv 182
Cdd:COG2319 143 TVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAvRSVAFSPDGK----- 217

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654216 183 vmnkvdvyHLDTASVSGT-----LTNGK----------RISAITFLSD-SVLAVAGDEEVVRFFDCDTLVCLCEFKAHEN 246
Cdd:COG2319 218 --------LLASGSADGTvrlwdLATGKllrtltghsgSVRSVAFSPDgRLLASGSADGTVRLWDLATGELLRTLTGHSG 289

                       250       260       270
                ....*....|....*....|....*....|
gi 82654216 247 RVKDmVSFeIPDHHVLVTASNDGFIKMWTL 276
Cdd:COG2319 290 GVNS-VAF-SPDGKLLASGSDDGTVRLWDL 317
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 41-280 9.00e-27

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 107.81  E-value: 9.00e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654216  41 HTASLSAVA--ANNRYVVTGSKDETIHIYDMKKKVEHGALVHHSGTVTCLKFYGSRH-LISGAEDGLICVWDAKKWECLK 117
Cdd:cd00200   8 HTGGVTCVAfsPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTyLASGSSDKTIRLWDLETGECVR 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654216 118 SIKAHRGHVTFLSIHPSGKLALSVGTDKTLRTWNLVEGRsaFIKNIKqnahivewspngekyvvvvmnkvdvYHLDTasv 197
Cdd:cd00200  88 TLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGK--CLTTLR-------------------------GHTDW--- 137

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654216 198 sgtltngkrISAITFLSDS-VLAVAGDEEVVRFFDCDTLVCLCEFKAHENRVKdMVSFeIPDHHVLVTASNDGFIKMWTL 276
Cdd:cd00200 138 ---------VNSVAFSPDGtFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVN-SVAF-SPDGEKLLSSSSDGTIKLWDL 206


                ....
gi 82654216 277 TQDK 280
Cdd:cd00200 207 STGK 210
WD40 COG2319
WD40 repeat [General function prediction only];
27-277 6.92e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 104.61  E-value: 6.92e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654216  27 RETWTPVADFTHHAHTASLSAVAANNRYVVTGSKDETIHIYDMKKKVEHGALVHHSGTVTCLKF-YGSRHLISGAEDGLI 105
Cdd:COG2319  23 AALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFsPDGRLLASASADGTV 102

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654216 106 CVWDAKKWECLKSIKAHRGHVTFLSIHPSGKLALSVGTDKTLRTWNLVEGRsaFIKNIKQNAHIVE---WSPNGEkyvvv 182
Cdd:COG2319 103 RLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGK--LLRTLTGHSGAVTsvaFSPDGK----- 175

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654216 183 vmnkvdvyHLDTASVSGT-----LTNGK----------RISAITFLSDS-VLAVAGDEEVVRFFDCDTLVCLCEFKAHEN 246
Cdd:COG2319 176 --------LLASGSDDGTvrlwdLATGKllrtltghtgAVRSVAFSPDGkLLASGSADGTVRLWDLATGKLLRTLTGHSG 247

                       250       260       270
                ....*....|....*....|....*....|.
gi 82654216 247 RVKDmVSFEiPDHHVLVTASNDGFIKMWTLT 277
Cdd:COG2319 248 SVRS-VAFS-PDGRLLASGSADGTVRLWDLA 276
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 28-151 1.66e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 93.17  E-value: 1.66e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654216  28 ETWTPVAdfTHHAHTASLSAVAA--NNRYVVTGSKDETIHIYDMKKKVEHGALVHHSGTVTCLKFYGSRHLI-SGAEDGL 104
Cdd:cd00200 165 RTGKCVA--TLTGHTGEVNSVAFspDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLaSGSEDGT 242

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 82654216 105 ICVWDAKKWECLKSIKAHRGHVTFLSIHPSGKLALSVGTDKTLRTWN 151
Cdd:cd00200 243 IRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 39-176 1.76e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 90.47  E-value: 1.76e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654216  39 HAHTASLSAVAA--NNRYVVTGSKDETIHIYDMKKKVEHGALVHHSGTVTCLKFYGS-RHLISGAEDGLICVWDAKKWEC 115
Cdd:cd00200 132 RGHTDWVNSVAFspDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDgEKLLSSSSDGTIKLWDLSTGKC 211

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 82654216 116 LKSIKAHRGHVTFLSIHPSGKLALSVGTDKTLRTWNLVEGRSafIKNIKQNAHIVE---WSPNG 176
Cdd:cd00200 212 LGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGEC--VQTLSGHTNSVTslaWSPDG 273
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 115-274 1.43e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 67.36  E-value: 1.43e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654216 115 CLKSIKAHRGHVTFLSIHPSGKLALSVGTDKTLRTWNLVEGRsaFIKNIKQNAHIVEW---SPNGEK-YVVVVMNKVDVY 190
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGE--LLRTLKGHTGPVRDvaaSADGTYlASGSSDKTIRLW 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654216 191 HLDTASVSGTLTN-GKRISAITFLSD-SVLAVAGDEEVVRFFDCDTLVCLCEFKAHENRVKDmVSFeIPDHHVLVTASND 268
Cdd:cd00200  79 DLETGECVRTLTGhTSYVSSVAFSPDgRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNS-VAF-SPDGTFVASSSQD 156


                ....*.
gi 82654216 269 GFIKMW 274
Cdd:cd00200 157 GTIKLW 162
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 112-151 9.42e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.30  E-value: 9.42e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 82654216    112 KWECLKSIKAHRGHVTFLSIHPSGKLALSVGTDKTLRTWN 151
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
113-151 2.08e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.18  E-value: 2.08e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 82654216   113 WECLKSIKAHRGHVTFLSIHPSGKLALSVGTDKTLRTWN 151
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
8prop_heme_binding_protein cd20718
eight-bladed beta-propeller heme-binding domain in cytochrome cd1 and similar proteins; ...
 38-138 5.85e-05

eight-bladed beta-propeller heme-binding domain in cytochrome cd1 and similar proteins; Members here contain an 8-bladed beta-propeller heme-binding domain in cytochrome cd1 (nitrite reductase) and similar proteins including NirN and NirF. During denitrification, nitrate (Nar), nitrite (Nir), nitric oxide (Nor), and nitrous oxide (Nos) reductases catalyze the reaction cascade of NO(3-)-> NO(2-)-> NO -> N2O -> N2. The integral membrane proteins NorC, NorB, and NosR form the core assembly platform that binds the nitrate reductase NarGHI and the periplasmic nitrite reductase NirS via its maturation factor NirF. NirN and NirF form a stable complex with the nitrite reductase NirS during enzyme maturation. NirF is involved in heme d1 insertion.


Pssm-ID: 467720 [Multi-domain]  Cd Length: 380  Bit Score: 44.64  E-value: 5.85e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654216  38 HHAHTASLSAvaaNNRYVVTGS-KDETIHIYDMK-----KKVEHGALVH-HSGTVTCLKFYGSrhlISGAEDGLICVWDA 110
Cdd:cd20718 196 RPLHDAFLDP---DGRYFIVASqGSNTMWVLDLKtgkvvARIPTGKTPHpGPGATWGRKGVTA---TPHLGEGIVTVWDL 269

                        90       100
                ....*....|....*....|....*...
gi 82654216 111 KKWECLKSIKAHrGHVTFLSIHPSGKLA 138
Cdd:cd20718 270 DTWKPVKYIPTP-GPGRFVRTHPSSPYV 296
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 54-271 7.45e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 44.69  E-value: 7.45e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654216   54 YVVTGSKDETIHIYDMKKKVEHGALVHH-----------SGTvtCLKFYGSRHLISGAEDGLICVWDAKKWECLKSIKAH 122
Cdd:PLN00181 497 FFATAGVNKKIKIFECESIIKDGRDIHYpvvelasrsklSGI--CWNSYIKSQVASSNFEGVVQVWDVARSQLVTEMKEH 574

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654216  123 RGHVTFLSIHPSGKLALSVGTDK-TLRTWNLVEGRSafIKNIKQNAHI--VEWSPNGEKYVVVVMNKVDVYHLDTAS--- 196
Cdd:PLN00181 575 EKRVWSIDYSSADPTLLASGSDDgSVKLWSINQGVS--IGTIKTKANIccVQFPSESGRSLAFGSADHKVYYYDLRNpkl 652

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654216  197 -VSGTLTNGKRISAITFLSDSVLAVAGDEEVVRFFDCDTLVC------LCEFKAHENrVKDMVSFEIPDHHVLV-TASND 268
Cdd:PLN00181 653 pLCTMIGHSKTVSYVRFVDSSTLVSSSTDNTLKLWDLSMSISginetpLHSFMGHTN-VKNFVGLSVSDGYIATgSETNE 731


                 ...
gi 82654216  269 GFI 271
Cdd:PLN00181 732 VFV 734
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 234-274 9.57e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.22  E-value: 9.57e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 82654216    234 TLVCLCEFKAHENRVKDmVSFeIPDHHVLVTASNDGFIKMW 274
Cdd:smart00320   1 SGELLKTLKGHTGPVTS-VAF-SPDGKYLASGSDDGTIKLW 39
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 205-281 2.58e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 42.32  E-value: 2.58e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 82654216 205 KRISAITFLSDS-VLAVAGDEEVVRFFDCDTLVCLCEFKAHENRVKDmVSFeIPDHHVLVTASNDGFIKMWTLTQDKK 281
Cdd:cd00200  10 GGVTCVAFSPDGkLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRD-VAA-SADGTYLASGSSDKTIRLWDLETGEC 85
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 78-109 2.77e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.06  E-value: 2.77e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 82654216     78 LVHHSGTVTCLKFYG-SRHLISGAEDGLICVWD 109
Cdd:smart00320   8 LKGHTGPVTSVAFSPdGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
78-109 3.66e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.71  E-value: 3.66e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 82654216    78 LVHHSGTVTCLKF-YGSRHLISGAEDGLICVWD 109
Cdd:pfam00400   7 LEGHTGSVTSLAFsPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
237-274 1.95e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.78  E-value: 1.95e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 82654216   237 CLCEFKAHENRVKDMVSfeIPDHHVLVTASNDGFIKMW 274
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAF--SPDGKLLASGSDDGTVKVW 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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