nuclear speckle splicing regulatory protein 1 (NSRP1) family protein is a DUF2040 domain-containing protein similar to Schizosaccharomyces pombe NSRP1 homolog, also called coiled-coil domain-containing protein 55 homolog
Nuclear speckle splicing regulatory protein 1, RS-like domain; This domain found at the ...
290-460
4.72e-46
Nuclear speckle splicing regulatory protein 1, RS-like domain; This domain found at the C-terminal of Nuclear speckle splicing regulatory protein 1 (NRP1, also known as Nuclear speckle-related protein 70 and Coiled-coil domain-containing protein 55). This is the RS-like domain, that resembles the arginine/serine-rich (RS) domain in other SR proteins, interacts with two SR proteins and with target mRNA, being essential for NRP1 activity. NRP1 is a RNA-binding protein that mediates pre-mRNA alternative splicing regulation.
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Pssm-ID: 466576 [Multi-domain] Cd Length: 174 Bit Score: 159.24 E-value: 4.72e-46
Nuclear speckle splicing regulatory protein 1, N-terminal; This domain is found at the ...
57-176
1.10e-30
Nuclear speckle splicing regulatory protein 1, N-terminal; This domain is found at the N-terminal of Nuclear speckle splicing regulatory protein 1 (NRP1, also known as Nuclear speckle-related protein 70 and Coiled-coil domain-containing protein 55) and contains a coiled-coil domain that plays a critical role in NRP1 alternative splicing activity and self-oligomerization. NRP1 is a RNA-binding protein that mediates pre-mRNA alternative splicing regulation.
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Pssm-ID: 462876 [Multi-domain] Cd Length: 121 Bit Score: 115.70 E-value: 1.10e-30
Nuclear speckle splicing regulatory protein 1, RS-like domain; This domain found at the ...
290-460
4.72e-46
Nuclear speckle splicing regulatory protein 1, RS-like domain; This domain found at the C-terminal of Nuclear speckle splicing regulatory protein 1 (NRP1, also known as Nuclear speckle-related protein 70 and Coiled-coil domain-containing protein 55). This is the RS-like domain, that resembles the arginine/serine-rich (RS) domain in other SR proteins, interacts with two SR proteins and with target mRNA, being essential for NRP1 activity. NRP1 is a RNA-binding protein that mediates pre-mRNA alternative splicing regulation.
Pssm-ID: 466576 [Multi-domain] Cd Length: 174 Bit Score: 159.24 E-value: 4.72e-46
Nuclear speckle splicing regulatory protein 1, N-terminal; This domain is found at the ...
57-176
1.10e-30
Nuclear speckle splicing regulatory protein 1, N-terminal; This domain is found at the N-terminal of Nuclear speckle splicing regulatory protein 1 (NRP1, also known as Nuclear speckle-related protein 70 and Coiled-coil domain-containing protein 55) and contains a coiled-coil domain that plays a critical role in NRP1 alternative splicing activity and self-oligomerization. NRP1 is a RNA-binding protein that mediates pre-mRNA alternative splicing regulation.
Pssm-ID: 462876 [Multi-domain] Cd Length: 121 Bit Score: 115.70 E-value: 1.10e-30
U2 snRNP auxilliary factor, large subunit, splicing factor; These splicing factors consist of ...
353-483
1.32e-04
U2 snRNP auxilliary factor, large subunit, splicing factor; These splicing factors consist of an N-terminal arginine-rich low complexity domain followed by three tandem RNA recognition motifs (pfam00076). The well-characterized members of this family are auxilliary components of the U2 small nuclear ribonuclearprotein splicing factor (U2AF). These proteins are closely related to the CC1-like subfamily of splicing factors (TIGR01622). Members of this subfamily are found in plants, metazoa and fungi.
Pssm-ID: 273727 [Multi-domain] Cd Length: 509 Bit Score: 44.50 E-value: 1.32e-04
Nuclear speckle splicing regulatory protein 1, RS-like domain; This domain found at the ...
290-460
4.72e-46
Nuclear speckle splicing regulatory protein 1, RS-like domain; This domain found at the C-terminal of Nuclear speckle splicing regulatory protein 1 (NRP1, also known as Nuclear speckle-related protein 70 and Coiled-coil domain-containing protein 55). This is the RS-like domain, that resembles the arginine/serine-rich (RS) domain in other SR proteins, interacts with two SR proteins and with target mRNA, being essential for NRP1 activity. NRP1 is a RNA-binding protein that mediates pre-mRNA alternative splicing regulation.
Pssm-ID: 466576 [Multi-domain] Cd Length: 174 Bit Score: 159.24 E-value: 4.72e-46
Nuclear speckle splicing regulatory protein 1, N-terminal; This domain is found at the ...
57-176
1.10e-30
Nuclear speckle splicing regulatory protein 1, N-terminal; This domain is found at the N-terminal of Nuclear speckle splicing regulatory protein 1 (NRP1, also known as Nuclear speckle-related protein 70 and Coiled-coil domain-containing protein 55) and contains a coiled-coil domain that plays a critical role in NRP1 alternative splicing activity and self-oligomerization. NRP1 is a RNA-binding protein that mediates pre-mRNA alternative splicing regulation.
Pssm-ID: 462876 [Multi-domain] Cd Length: 121 Bit Score: 115.70 E-value: 1.10e-30
U2 snRNP auxilliary factor, large subunit, splicing factor; These splicing factors consist of ...
353-483
1.32e-04
U2 snRNP auxilliary factor, large subunit, splicing factor; These splicing factors consist of an N-terminal arginine-rich low complexity domain followed by three tandem RNA recognition motifs (pfam00076). The well-characterized members of this family are auxilliary components of the U2 small nuclear ribonuclearprotein splicing factor (U2AF). These proteins are closely related to the CC1-like subfamily of splicing factors (TIGR01622). Members of this subfamily are found in plants, metazoa and fungi.
Pssm-ID: 273727 [Multi-domain] Cd Length: 509 Bit Score: 44.50 E-value: 1.32e-04
splicing factor, CC1-like family; This model represents a subfamily of RNA splicing factors ...
370-494
1.02e-03
splicing factor, CC1-like family; This model represents a subfamily of RNA splicing factors including the Pad-1 protein (N. crassa), CAPER (M. musculus) and CC1.3 (H.sapiens). These proteins are characterized by an N-terminal arginine-rich, low complexity domain followed by three (or in the case of 4 H. sapiens paralogs, two) RNA recognition domains (rrm: pfam00706). These splicing factors are closely related to the U2AF splicing factor family (TIGR01642). A homologous gene from Plasmodium falciparum was identified in the course of the analysis of that genome at TIGR and was included in the seed.
Pssm-ID: 273721 [Multi-domain] Cd Length: 494 Bit Score: 41.83 E-value: 1.02e-03
splicing factor, CC1-like family; This model represents a subfamily of RNA splicing factors ...
349-467
1.50e-03
splicing factor, CC1-like family; This model represents a subfamily of RNA splicing factors including the Pad-1 protein (N. crassa), CAPER (M. musculus) and CC1.3 (H.sapiens). These proteins are characterized by an N-terminal arginine-rich, low complexity domain followed by three (or in the case of 4 H. sapiens paralogs, two) RNA recognition domains (rrm: pfam00706). These splicing factors are closely related to the U2AF splicing factor family (TIGR01642). A homologous gene from Plasmodium falciparum was identified in the course of the analysis of that genome at TIGR and was included in the seed.
Pssm-ID: 273721 [Multi-domain] Cd Length: 494 Bit Score: 41.06 E-value: 1.50e-03
U2 snRNP auxilliary factor, large subunit, splicing factor; These splicing factors consist of ...
365-499
7.77e-03
U2 snRNP auxilliary factor, large subunit, splicing factor; These splicing factors consist of an N-terminal arginine-rich low complexity domain followed by three tandem RNA recognition motifs (pfam00076). The well-characterized members of this family are auxilliary components of the U2 small nuclear ribonuclearprotein splicing factor (U2AF). These proteins are closely related to the CC1-like subfamily of splicing factors (TIGR01622). Members of this subfamily are found in plants, metazoa and fungi.
Pssm-ID: 273727 [Multi-domain] Cd Length: 509 Bit Score: 39.11 E-value: 7.77e-03
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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