phosphatidate cytidylyltransferase, mitochondrial precursor [Danio rerio]
phosphatidate cytidylyltransferase( domain architecture ID 10557553)
phosphatidate cytidylyltransferase catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol
List of domain hits
Name | Accession | Description | Interval | E-value | ||||||
Tam41_Mmp37 | pfam09139 | Phosphatidate cytidylyltransferase, mitochondrial; Tam41 also known as MMp37 is a ... |
13-328 | 8.33e-156 | ||||||
Phosphatidate cytidylyltransferase, mitochondrial; Tam41 also known as MMp37 is a mitochondrial phosphatidate cytidylyltransferase (CDP-DAG synthase)(EC:2.7.7.41) that catalyzes the formation of CDP-diacylglycerol (CDP-DAG) from phosphatidic acid (PA) in the mitochondrial inner membrane. It is required for the biosynthesis of the dimeric phospholipid cardiolipin, which stabilizes supercomplexes of the mitochondrial respiratory chain in the mitochondrial inner membrane. It is suggested that the N-terminal portion of Tam41 may possess the NTase (Nucleotide Transferase) fold, which is consistent with the CDP-DAG synthase function of Tam41. Furthermore, it has been shown that Tam41/MMP37 proteins possess the NTase fold but they have only one active site carboxylate and thus probably are not able to carry out enzymatic reaction. These potentially non-active members of NTase fold superfamily may bind ATP, hydrolysis of which is necessary for the translocation of proteins through the membrane. : Pssm-ID: 462690 Cd Length: 322 Bit Score: 439.27 E-value: 8.33e-156
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Name | Accession | Description | Interval | E-value | ||||||
Tam41_Mmp37 | pfam09139 | Phosphatidate cytidylyltransferase, mitochondrial; Tam41 also known as MMp37 is a ... |
13-328 | 8.33e-156 | ||||||
Phosphatidate cytidylyltransferase, mitochondrial; Tam41 also known as MMp37 is a mitochondrial phosphatidate cytidylyltransferase (CDP-DAG synthase)(EC:2.7.7.41) that catalyzes the formation of CDP-diacylglycerol (CDP-DAG) from phosphatidic acid (PA) in the mitochondrial inner membrane. It is required for the biosynthesis of the dimeric phospholipid cardiolipin, which stabilizes supercomplexes of the mitochondrial respiratory chain in the mitochondrial inner membrane. It is suggested that the N-terminal portion of Tam41 may possess the NTase (Nucleotide Transferase) fold, which is consistent with the CDP-DAG synthase function of Tam41. Furthermore, it has been shown that Tam41/MMP37 proteins possess the NTase fold but they have only one active site carboxylate and thus probably are not able to carry out enzymatic reaction. These potentially non-active members of NTase fold superfamily may bind ATP, hydrolysis of which is necessary for the translocation of proteins through the membrane. Pssm-ID: 462690 Cd Length: 322 Bit Score: 439.27 E-value: 8.33e-156
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Name | Accession | Description | Interval | E-value | ||||||
Tam41_Mmp37 | pfam09139 | Phosphatidate cytidylyltransferase, mitochondrial; Tam41 also known as MMp37 is a ... |
13-328 | 8.33e-156 | ||||||
Phosphatidate cytidylyltransferase, mitochondrial; Tam41 also known as MMp37 is a mitochondrial phosphatidate cytidylyltransferase (CDP-DAG synthase)(EC:2.7.7.41) that catalyzes the formation of CDP-diacylglycerol (CDP-DAG) from phosphatidic acid (PA) in the mitochondrial inner membrane. It is required for the biosynthesis of the dimeric phospholipid cardiolipin, which stabilizes supercomplexes of the mitochondrial respiratory chain in the mitochondrial inner membrane. It is suggested that the N-terminal portion of Tam41 may possess the NTase (Nucleotide Transferase) fold, which is consistent with the CDP-DAG synthase function of Tam41. Furthermore, it has been shown that Tam41/MMP37 proteins possess the NTase fold but they have only one active site carboxylate and thus probably are not able to carry out enzymatic reaction. These potentially non-active members of NTase fold superfamily may bind ATP, hydrolysis of which is necessary for the translocation of proteins through the membrane. Pssm-ID: 462690 Cd Length: 322 Bit Score: 439.27 E-value: 8.33e-156
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