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Conserved domains on  [gi|79319153|ref|NP_001031137|]
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P-loop containing nucleoside triphosphate hydrolases superfamily protein [Arabidopsis thaliana]

Protein Classification

AIG1 domain-containing protein( domain architecture ID 10518548)

AIG1 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AIG1 pfam04548
AIG1 family; Arabidopsis protein AIG1 appears to be involved in plant resistance to bacteria.
 25-239 2.05e-94

AIG1 family; Arabidopsis protein AIG1 appears to be involved in plant resistance to bacteria.


:

Pssm-ID: 398307 [Multi-domain]  Cd Length: 200  Bit Score: 276.41  E-value: 2.05e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79319153    25 RTLVLVGRTGNGKSATGNSILGRKAFRSRARTVGVTSTCESQRVVQeDGDIINVVDTPGLFDLSTAADFIGKEIVRCISL 104
Cdd:pfam04548   1 LRIVLVGKTGNGKSATGNSILGRKAFESKLRAQGVTKTCQLVSRTW-DGRIINVIDTPGLFDLSVSNDFISKEIIRCLLL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79319153   105 AEDGIHAILLVFSVRRLAEEEQTVLSFLQALFGSKIADYMIVVFTGGDelEENEETLEEYLADYCPEFLKEILgicdnrl 184
Cdd:pfam04548  80 AEPGPHAVLLVLSLGRFTEEEEQALRTLQELFGSKILDYMIVVFTRKD--DLEDDSLDDYLSDGCPEFLKEVL------- 150

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 79319153   185 vlfnnKTTDKVKKAEQVQKLLSLVESVVKQNNGKPYSDELFHELQEEAIKLRDQK 239
Cdd:pfam04548 151 -----RTADGEEKEEQVQQLLALVEAIVKENGGKPYTNDLYEKIKEEGERLREQQ 200
 
Name Accession Description Interval E-value
AIG1 pfam04548
AIG1 family; Arabidopsis protein AIG1 appears to be involved in plant resistance to bacteria.
 25-239 2.05e-94

AIG1 family; Arabidopsis protein AIG1 appears to be involved in plant resistance to bacteria.


Pssm-ID: 398307 [Multi-domain]  Cd Length: 200  Bit Score: 276.41  E-value: 2.05e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79319153    25 RTLVLVGRTGNGKSATGNSILGRKAFRSRARTVGVTSTCESQRVVQeDGDIINVVDTPGLFDLSTAADFIGKEIVRCISL 104
Cdd:pfam04548   1 LRIVLVGKTGNGKSATGNSILGRKAFESKLRAQGVTKTCQLVSRTW-DGRIINVIDTPGLFDLSVSNDFISKEIIRCLLL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79319153   105 AEDGIHAILLVFSVRRLAEEEQTVLSFLQALFGSKIADYMIVVFTGGDelEENEETLEEYLADYCPEFLKEILgicdnrl 184
Cdd:pfam04548  80 AEPGPHAVLLVLSLGRFTEEEEQALRTLQELFGSKILDYMIVVFTRKD--DLEDDSLDDYLSDGCPEFLKEVL------- 150

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 79319153   185 vlfnnKTTDKVKKAEQVQKLLSLVESVVKQNNGKPYSDELFHELQEEAIKLRDQK 239
Cdd:pfam04548 151 -----RTADGEEKEEQVQQLLALVEAIVKENGGKPYTNDLYEKIKEEGERLREQQ 200
AIG1 cd01852
AvrRpt2-Induced Gene 1 (AIG1); This group represents Arabidoposis protein AIG1 ...
 25-230 3.26e-94

AvrRpt2-Induced Gene 1 (AIG1); This group represents Arabidoposis protein AIG1 (avrRpt2-induced gene 1) that appears to be involved in plant resistance to bacteria. The Arabidopsis disease resistance gene RPS2 is involved in recognition of bacterial pathogens carrying the avirulence gene avrRpt2. AIG1 exhibits RPS2- and avrRpt1-dependent induction early after infection with Pseudomonas syringae carrying avrRpt2. This subfamily also includes IAN-4 protein, which has GTP-binding activity and shares sequence homology with a novel family of putative GTP-binding proteins: the immuno-associated nucleotide (IAN) family. The evolutionary conservation of the IAN family provides a unique example of a plant pathogen response gene conserved in animals. The IAN/IMAP subfamily has been proposed to regulate apoptosis in vertebrates and angiosperm plants, particularly in relation to cancer, diabetes, and infections. The human IAN genes were renamed GIMAP (GTPase of the immunity associated proteins).


Pssm-ID: 206651 [Multi-domain]  Cd Length: 201  Bit Score: 275.95  E-value: 3.26e-94
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79319153  25 RTLVLVGRTGNGKSATGNSILGRKAFRSRARTVGVTSTCESQRVVQeDGDIINVVDTPGLFDLSTAADFIGKEIVRCISL 104
Cdd:cd01852   1 LRLVLVGKTGNGKSATGNTILGRKVFESKLSASGVTKTCQKESAVW-DGRRVNVIDTPGLFDTSVSPEQLSKEIIRCLSL 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79319153 105 AEDGIHAILLVFSVRRLAEEEQTVLSFLQALFGSKIADYMIVVFTGGDELEENEETleeylaDY---CPEFLKEILGICD 181
Cdd:cd01852  80 SAPGPHAFLLVVPLGRFTEEEEQAVEELQELFGEKVLDHTIVLFTRGDDLEGGSLE------DYledSCEALKRLLEKCG 153

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 79319153 182 NRLVLFNNKTTDKvKKAEQVQKLLSLVESVVKQNNGKPYSDELFHELQE 230
Cdd:cd01852 154 GRYVAFNNKAKGR-EQEQQVKELLAKVEEMVRENGGKPYTNEMYEEAEE 201
YeeP COG3596
Predicted GTPase [General function prediction only];
26-149 6.15e-09

Predicted GTPase [General function prediction only];


Pssm-ID: 442815 [Multi-domain]  Cd Length: 318  Bit Score: 55.93  E-value: 6.15e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79319153  26 TLVLVGRTGNGKSATGNSILGrkafRSRART-VGVTSTCESQRVV--QEDGDIINVVDTPGLFDlSTAADFIGKEIVRCI 102
Cdd:COG3596  41 VIALVGKTGAGKSSLINALFG----AEVAEVgVGRPCTREIQRYRleSDGLPGLVLLDTPGLGE-VNERDREYRELRELL 115

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 79319153 103 SLAedgiHAILLVFSVRRLAeeEQTVLSFLQALFGSKIADYMIVVFT 149
Cdd:COG3596 116 PEA----DLILWVVKADDRA--LATDEEFLQALRAQYPDPPVLVVLT 156
3a0901s04IAP86 TIGR00993
chloroplast protein import component Toc86/159, G and M domains; The long precursor of the 86K ...
 26-92 1.06e-06

chloroplast protein import component Toc86/159, G and M domains; The long precursor of the 86K protein originally described is proposed to have three domains. The N-terminal A-domain is acidic, repetitive, weakly conserved, readily removed by proteolysis during chloroplast isolation, and not required for protein translocation. The other domains are designated G (GTPase) and M (membrane anchor); this family includes most of the G domain and all of M. [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273381 [Multi-domain]  Cd Length: 763  Bit Score: 49.57  E-value: 1.06e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 79319153    26 TLVLVGRTGNGKSATGNSILGRKAFRSRARTVGVTSTCESQRVVQedGDIINVVDTPGLfdLSTAAD 92
Cdd:TIGR00993 120 NILVLGKSGVGKSATINSIFGEVKFSTDAFGMGTTSVQEIEGLVQ--GVKIRVIDTPGL--KSSASD 182
 
Name Accession Description Interval E-value
AIG1 pfam04548
AIG1 family; Arabidopsis protein AIG1 appears to be involved in plant resistance to bacteria.
 25-239 2.05e-94

AIG1 family; Arabidopsis protein AIG1 appears to be involved in plant resistance to bacteria.


Pssm-ID: 398307 [Multi-domain]  Cd Length: 200  Bit Score: 276.41  E-value: 2.05e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79319153    25 RTLVLVGRTGNGKSATGNSILGRKAFRSRARTVGVTSTCESQRVVQeDGDIINVVDTPGLFDLSTAADFIGKEIVRCISL 104
Cdd:pfam04548   1 LRIVLVGKTGNGKSATGNSILGRKAFESKLRAQGVTKTCQLVSRTW-DGRIINVIDTPGLFDLSVSNDFISKEIIRCLLL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79319153   105 AEDGIHAILLVFSVRRLAEEEQTVLSFLQALFGSKIADYMIVVFTGGDelEENEETLEEYLADYCPEFLKEILgicdnrl 184
Cdd:pfam04548  80 AEPGPHAVLLVLSLGRFTEEEEQALRTLQELFGSKILDYMIVVFTRKD--DLEDDSLDDYLSDGCPEFLKEVL------- 150

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 79319153   185 vlfnnKTTDKVKKAEQVQKLLSLVESVVKQNNGKPYSDELFHELQEEAIKLRDQK 239
Cdd:pfam04548 151 -----RTADGEEKEEQVQQLLALVEAIVKENGGKPYTNDLYEKIKEEGERLREQQ 200
AIG1 cd01852
AvrRpt2-Induced Gene 1 (AIG1); This group represents Arabidoposis protein AIG1 ...
 25-230 3.26e-94

AvrRpt2-Induced Gene 1 (AIG1); This group represents Arabidoposis protein AIG1 (avrRpt2-induced gene 1) that appears to be involved in plant resistance to bacteria. The Arabidopsis disease resistance gene RPS2 is involved in recognition of bacterial pathogens carrying the avirulence gene avrRpt2. AIG1 exhibits RPS2- and avrRpt1-dependent induction early after infection with Pseudomonas syringae carrying avrRpt2. This subfamily also includes IAN-4 protein, which has GTP-binding activity and shares sequence homology with a novel family of putative GTP-binding proteins: the immuno-associated nucleotide (IAN) family. The evolutionary conservation of the IAN family provides a unique example of a plant pathogen response gene conserved in animals. The IAN/IMAP subfamily has been proposed to regulate apoptosis in vertebrates and angiosperm plants, particularly in relation to cancer, diabetes, and infections. The human IAN genes were renamed GIMAP (GTPase of the immunity associated proteins).


Pssm-ID: 206651 [Multi-domain]  Cd Length: 201  Bit Score: 275.95  E-value: 3.26e-94
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79319153  25 RTLVLVGRTGNGKSATGNSILGRKAFRSRARTVGVTSTCESQRVVQeDGDIINVVDTPGLFDLSTAADFIGKEIVRCISL 104
Cdd:cd01852   1 LRLVLVGKTGNGKSATGNTILGRKVFESKLSASGVTKTCQKESAVW-DGRRVNVIDTPGLFDTSVSPEQLSKEIIRCLSL 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79319153 105 AEDGIHAILLVFSVRRLAEEEQTVLSFLQALFGSKIADYMIVVFTGGDELEENEETleeylaDY---CPEFLKEILGICD 181
Cdd:cd01852  80 SAPGPHAFLLVVPLGRFTEEEEQAVEELQELFGEKVLDHTIVLFTRGDDLEGGSLE------DYledSCEALKRLLEKCG 153

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 79319153 182 NRLVLFNNKTTDKvKKAEQVQKLLSLVESVVKQNNGKPYSDELFHELQE 230
Cdd:cd01852 154 GRYVAFNNKAKGR-EQEQQVKELLAKVEEMVRENGGKPYTNEMYEEAEE 201
YeeP COG3596
Predicted GTPase [General function prediction only];
26-149 6.15e-09

Predicted GTPase [General function prediction only];


Pssm-ID: 442815 [Multi-domain]  Cd Length: 318  Bit Score: 55.93  E-value: 6.15e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79319153  26 TLVLVGRTGNGKSATGNSILGrkafRSRART-VGVTSTCESQRVV--QEDGDIINVVDTPGLFDlSTAADFIGKEIVRCI 102
Cdd:COG3596  41 VIALVGKTGAGKSSLINALFG----AEVAEVgVGRPCTREIQRYRleSDGLPGLVLLDTPGLGE-VNERDREYRELRELL 115

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 79319153 103 SLAedgiHAILLVFSVRRLAeeEQTVLSFLQALFGSKIADYMIVVFT 149
Cdd:COG3596 116 PEA----DLILWVVKADDRA--LATDEEFLQALRAQYPDPPVLVVLT 156
Ras_like_GTPase cd00882
Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Ras-like ...
 28-206 4.22e-08

Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras, Rho, Rab, and Sar1/Arf families. This superfamily also includes proteins like the GTP translation factors, Era-like GTPases, and G-alpha chain of the heterotrimeric G proteins. Members of the Ras superfamily regulate a wide variety of cellular functions: the Ras family regulates gene expression, the Rho family regulates cytoskeletal reorganization and gene expression, the Rab and Sar1/Arf families regulate vesicle trafficking, and the Ran family regulates nucleocytoplasmic transport and microtubule organization. The GTP translation factor family regulates initiation, elongation, termination, and release in translation, and the Era-like GTPase family regulates cell division, sporulation, and DNA replication. Members of the Ras superfamily are identified by the GTP binding site, which is made up of five characteristic sequence motifs, and the switch I and switch II regions.


Pssm-ID: 206648 [Multi-domain]  Cd Length: 161  Bit Score: 51.69  E-value: 4.22e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79319153  28 VLVGRTGNGKSATGNSILGRKaFRSRARTVGVTSTCESQRV-VQEDGDIINVVDTPGLFdlstaaDFIGKEIVRCISLAE 106
Cdd:cd00882   1 VVVGRGGVGKSSLLNALLGGE-VGEVSDVPGTTRDPDVYVKeLDKGKVKLVLVDTPGLD------EFGGLGREELARLLL 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79319153 107 DGIHAILLVFSVRRLAEEEQTVLSFLQALFGSKIadYMIVVFTGGDELEENEETLeeyladycPEFLKEILGICDNRLVL 186
Cdd:cd00882  74 RGADLILLVVDSTDRESEEDAKLLILRRLRKEGI--PIILVGNKIDLLEEREVEE--------LLRLEELAKILGVPVFE 143

                       170       180
                ....*....|....*....|
gi 79319153 187 FNNKTTDKVKkaEQVQKLLS 206
Cdd:cd00882 144 VSAKTGEGVD--ELFEKLIE 161
Toc34_like cd01853
Translocon at the Outer-envelope membrane of Chloroplasts 34-like (Toc34-like); The Toc34-like ...
 26-149 4.31e-08

Translocon at the Outer-envelope membrane of Chloroplasts 34-like (Toc34-like); The Toc34-like (Translocon at the Outer-envelope membrane of Chloroplasts) family contains several Toc proteins, including Toc34, Toc33, Toc120, Toc159, Toc86, Toc125, and Toc90. The Toc complex at the outer envelope membrane of chloroplasts is a molecular machine of ~500 kDa that contains a single Toc159 protein, four Toc75 molecules, and four or five copies of Toc34. Toc64 and Toc12 are associated with the translocon, but do not appear to be part of the core complex. The Toc translocon initiates the import of nuclear-encoded preproteins from the cytosol into the organelle. Toc34 and Toc159 are both GTPases, while Toc75 is a beta-barrel integral membrane protein. Toc159 is equally distributed between a soluble cytoplasmic form and a membrane-inserted form, suggesting that assembly of the Toc complex is dynamic. Toc34 and Toc75 act sequentially to mediate docking and insertion of Toc159 resulting in assembly of the functional translocon.


Pssm-ID: 206652  Cd Length: 248  Bit Score: 52.71  E-value: 4.31e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79319153  26 TLVLVGRTGNGKSATGNSILGRKAFRSRARTVGVTSTCESQRVVqeDGDIINVVDTPGLfdLSTAADFIGKEIVRCIS-- 103
Cdd:cd01853  33 TILVLGKTGVGKSSTINSIFGERKVSVSAFQSETLRPREVSRTV--DGFKLNIIDTPGL--LESQDQRVNRKILSIIKrf 108

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 79319153 104 LAEDGIHAILLV--FSVRRLAEEEQTVLSFLQALFGSKIADYMIVVFT 149
Cdd:cd01853 109 LKKKTIDVVLYVdrLDMYRVDNLDVPLLRAITDSFGPSIWRNAIVVLT 156
3a0901s04IAP86 TIGR00993
chloroplast protein import component Toc86/159, G and M domains; The long precursor of the 86K ...
 26-92 1.06e-06

chloroplast protein import component Toc86/159, G and M domains; The long precursor of the 86K protein originally described is proposed to have three domains. The N-terminal A-domain is acidic, repetitive, weakly conserved, readily removed by proteolysis during chloroplast isolation, and not required for protein translocation. The other domains are designated G (GTPase) and M (membrane anchor); this family includes most of the G domain and all of M. [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273381 [Multi-domain]  Cd Length: 763  Bit Score: 49.57  E-value: 1.06e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 79319153    26 TLVLVGRTGNGKSATGNSILGRKAFRSRARTVGVTSTCESQRVVQedGDIINVVDTPGLfdLSTAAD 92
Cdd:TIGR00993 120 NILVLGKSGVGKSATINSIFGEVKFSTDAFGMGTTSVQEIEGLVQ--GVKIRVIDTPGL--KSSASD 182
Era_like cd00880
E. coli Ras-like protein (Era)-like GTPase; The Era (E. coli Ras-like protein)-like family ...
 28-149 8.26e-06

E. coli Ras-like protein (Era)-like GTPase; The Era (E. coli Ras-like protein)-like family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngB), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs), to the exclusion of other GTPases. TrmE is ubiquitous in bacteria and is a widespread mitochondrial protein in eukaryotes, but is absent from archaea. The yeast member of TrmE family, MSS1, is involved in mitochondrial translation; bacterial members are often present in translation-related operons. FeoB represents an unusual adaptation of GTPases for high-affinity iron (II) transport. YihA (EngB) family of GTPases is typified by the E. coli YihA, which is an essential protein involved in cell division control. Era is characterized by a distinct derivative of the KH domain (the pseudo-KH domain) which is located C-terminal to the GTPase domain. EngA and its orthologs are composed of two GTPase domains and, since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that an ancient gene duplication, rather than a fusion of evolutionarily distinct GTPases, gave rise to this family.


Pssm-ID: 206646 [Multi-domain]  Cd Length: 161  Bit Score: 44.93  E-value: 8.26e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79319153  28 VLVGRTGNGKSATGNSILGRKAFRSrARTVGVTSTCESQRVVQEDGDIINVVDTPGLFDLSTAADFIGKEIVRcislAED 107
Cdd:cd00880   1 AIFGRPNVGKSSLLNALLGQNVGIV-SPIPGTTRDPVRKEWELLPLGPVVLIDTPGLDEEGGLGRERVEEARQ----VAD 75

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 79319153 108 GIHAILLVFSVRRLAEEEQTVlsfLQALFGSKIAdyMIVVFT 149
Cdd:cd00880  76 RADLVLLVVDSDLTPVEEEAK---LGLLRERGKP--VLLVLN 112
MMR_HSR1 pfam01926
50S ribosome-binding GTPase; The full-length GTPase protein is required for the complete ...
 26-149 1.18e-04

50S ribosome-binding GTPase; The full-length GTPase protein is required for the complete activity of the protein of interacting with the 50S ribosome and binding of both adenine and guanine nucleotides, with a preference for guanine nucleotide.


Pssm-ID: 460387 [Multi-domain]  Cd Length: 113  Bit Score: 40.68  E-value: 1.18e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79319153    26 TLVLVGRTGNGKSATGNSILGRKAFRSraRTVGVTsTCESQRVVQEDGDIINVVDTPGLFDLSTAADFIGKEIVRCISla 105
Cdd:pfam01926   1 RVALVGRPNVGKSTLINALTGAKAIVS--DYPGTT-RDPNEGRLELKGKQIILVDTPGLIEGASEGEGLGRAFLAIIE-- 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 79319153   106 EDGIhaILLVFSVRRLAEEEQTVLSFLQalfgsKIADYMIVVFT 149
Cdd:pfam01926  76 ADLI--LFVVDSEEGITPLDEELLELLR-----ENKKPIILVLN 112
CDC_Septin cd01850
CDC/Septin GTPase family; Septins are a conserved family of GTP-binding proteins associated ...
 26-97 2.09e-04

CDC/Septin GTPase family; Septins are a conserved family of GTP-binding proteins associated with diverse processes in dividing and non-dividing cells. They were first discovered in the budding yeast S. cerevisiae as a set of genes (CDC3, CDC10, CDC11 and CDC12) required for normal bud morphology. Septins are also present in metazoan cells, where they are required for cytokinesis in some systems, and implicated in a variety of other processes involving organization of the cell cortex and exocytosis. In humans, 12 septin genes generate dozens of polypeptides, many of which comprise heterooligomeric complexes. Since septin mutants are commonly defective in cytokinesis and formation of the neck formation of the neck filaments/septin rings, septins have been considered to be the primary constituents of the neck filaments. Septins belong to the GTPase superfamily for their conserved GTPase motifs and enzymatic activities.


Pssm-ID: 206649  Cd Length: 275  Bit Score: 41.76  E-value: 2.09e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79319153  26 TLVLVGRTGNGKSATGNSILGRKAFRSR---ARTVGVTSTCE--SQRVVQEDGDI---INVVDTPGLfdlstaADFIGKE 97
Cdd:cd01850   6 NIMVVGESGLGKSTFINTLFGTKLYPSKyppAPGEHITKTVEikISKAELEENGVklkLTVIDTPGF------GDNINNS 79
3a0901s02IAP34 TIGR00991
GTP-binding protein (Chloroplast Envelope Protein Translocase); [Transport and binding ...
 3-149 5.20e-04

GTP-binding protein (Chloroplast Envelope Protein Translocase); [Transport and binding proteins, Nucleosides, purines and pyrimidines]


Pssm-ID: 130064  Cd Length: 313  Bit Score: 40.65  E-value: 5.20e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79319153     3 LLDMGGDMMEDDwefASSsnpkRTLVLVGRTGNGKSATGNSILGRK-----AFRSRA-RTVGVTSTcesqrvvqEDGDII 76
Cdd:TIGR00991  24 LLELLGKLKEED---VSS----LTILVMGKGGVGKSSTVNSIIGERiatvsAFQSEGlRPMMVSRT--------RAGFTL 88

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 79319153    77 NVVDTPGLFDlstaADFIGKEIVRCIS--LAEDGIHAILLV--FSVRRLAEEEQTVLSFLQALFGSKIADYMIVVFT 149
Cdd:TIGR00991  89 NIIDTPGLIE----GGYINDQAVNIIKrfLLGKTIDVLLYVdrLDAYRVDTLDGQVIRAITDSFGKDIWRKSLVVLT 161
YfjP cd11383
YfjP GTPase; The Era (E. coli Ras-like protein)-like YfjP subfamily includes several ...
 28-83 3.41e-03

YfjP GTPase; The Era (E. coli Ras-like protein)-like YfjP subfamily includes several uncharacterized bacterial GTPases that are similar to Era. They generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs), to the exclusion of other GTPases. Era is characterized by a distinct derivative of the KH domain (the pseudo-KH domain) which is located C-terminal to the GTPase domain.


Pssm-ID: 206743 [Multi-domain]  Cd Length: 140  Bit Score: 36.93  E-value: 3.41e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 79319153  28 VLVGRTGNGKSATGNSIlgrkaFRSRARTVGVTSTC--ESQRVV-QEDGDIINVVDTPG 83
Cdd:cd11383   1 GLMGKTGAGKSSLCNAL-----FGTEVAAVGDRRPTtrAAQAYVwQTGGDGLVLLDLPG 54
small_GTP TIGR00231
small GTP-binding protein domain; Proteins with a small GTP-binding domain recognized by this ...
 27-83 4.94e-03

small GTP-binding protein domain; Proteins with a small GTP-binding domain recognized by this model include Ras, RhoA, Rab11, translation elongation factor G, translation initiation factor IF-2, tetratcycline resistance protein TetM, CDC42, Era, ADP-ribosylation factors, tdhF, and many others. In some proteins the domain occurs more than once.This model recognizes a large number of small GTP-binding proteins and related domains in larger proteins. Note that the alpha chains of heterotrimeric G proteins are larger proteins in which the NKXD motif is separated from the GxxxxGK[ST] motif (P-loop) by a long insert and are not easily detected by this model. [Unknown function, General]


Pssm-ID: 272973 [Multi-domain]  Cd Length: 162  Bit Score: 36.97  E-value: 4.94e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 79319153    27 LVLVGRTGNGKSATGNSILGRKAFRSrARTVGVTSTCESQrVVQEDGDI--INVVDTPG 83
Cdd:TIGR00231   4 IVIVGHPNVGKSTLLNSLLGNKGSIT-EYYPGTTRNYVTT-VIEEDGKTykFNLLDTAG 60
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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