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Conserved domains on  [gi|85702097|ref|NP_001028955|]
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prostate and testis expressed H precursor [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TFP_LU_ECD_SP10_like cd23628
extracellular domain (ECD) found in acrosomal protein SP-10, prostate and testis expressed ...
 22-100 4.65e-31

extracellular domain (ECD) found in acrosomal protein SP-10, prostate and testis expressed protein 14 (Pate14) and similar proteins; The family includes SP-10 and Pate14. SP-10 (also called acrosomal vesicle protein 1 (ACRV1)) is a human intra-acrosomal protein that is first detected in the developing acrosome of round spermatids and is observed associated with the acrosomal membranes and matrix of mature sperm. Pate14 ( also called prostate and testis expressed 14, or secreted seminal-vesicle Ly-6 protein 1 (SSLP-1)) is a secreted Ly-6 protein purified from mouse seminal vesicle fluid. Members in this family contain an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


:

Pssm-ID: 467148  Cd Length: 79  Bit Score: 104.68  E-value: 4.65e-31
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 85702097  22 EALKCFQCTLFNSKGKCLFQEPPCETQNNEVCVLWAKFEGGRFMYGFQECSHTCVNQTLNLRNKRIEMKCCNDKSFCNK 100
Cdd:cd23628   1 QALTCFQCDRMNSDGICETGEGTCEAQNSQQCMLKKIFEGGKLQYGVQGCSNLCPNMTLFSGNTRVEITCCRNQSFCNK 79
 
Name Accession Description Interval E-value
TFP_LU_ECD_SP10_like cd23628
extracellular domain (ECD) found in acrosomal protein SP-10, prostate and testis expressed ...
 22-100 4.65e-31

extracellular domain (ECD) found in acrosomal protein SP-10, prostate and testis expressed protein 14 (Pate14) and similar proteins; The family includes SP-10 and Pate14. SP-10 (also called acrosomal vesicle protein 1 (ACRV1)) is a human intra-acrosomal protein that is first detected in the developing acrosome of round spermatids and is observed associated with the acrosomal membranes and matrix of mature sperm. Pate14 ( also called prostate and testis expressed 14, or secreted seminal-vesicle Ly-6 protein 1 (SSLP-1)) is a secreted Ly-6 protein purified from mouse seminal vesicle fluid. Members in this family contain an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467148  Cd Length: 79  Bit Score: 104.68  E-value: 4.65e-31
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 85702097  22 EALKCFQCTLFNSKGKCLFQEPPCETQNNEVCVLWAKFEGGRFMYGFQECSHTCVNQTLNLRNKRIEMKCCNDKSFCNK 100
Cdd:cd23628   1 QALTCFQCDRMNSDGICETGEGTCEAQNSQQCMLKKIFEGGKLQYGVQGCSNLCPNMTLFSGNTRVEITCCRNQSFCNK 79
 
Name Accession Description Interval E-value
TFP_LU_ECD_SP10_like cd23628
extracellular domain (ECD) found in acrosomal protein SP-10, prostate and testis expressed ...
 22-100 4.65e-31

extracellular domain (ECD) found in acrosomal protein SP-10, prostate and testis expressed protein 14 (Pate14) and similar proteins; The family includes SP-10 and Pate14. SP-10 (also called acrosomal vesicle protein 1 (ACRV1)) is a human intra-acrosomal protein that is first detected in the developing acrosome of round spermatids and is observed associated with the acrosomal membranes and matrix of mature sperm. Pate14 ( also called prostate and testis expressed 14, or secreted seminal-vesicle Ly-6 protein 1 (SSLP-1)) is a secreted Ly-6 protein purified from mouse seminal vesicle fluid. Members in this family contain an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467148  Cd Length: 79  Bit Score: 104.68  E-value: 4.65e-31
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 85702097  22 EALKCFQCTLFNSKGKCLFQEPPCETQNNEVCVLWAKFEGGRFMYGFQECSHTCVNQTLNLRNKRIEMKCCNDKSFCNK 100
Cdd:cd23628   1 QALTCFQCDRMNSDGICETGEGTCEAQNSQQCMLKKIFEGGKLQYGVQGCSNLCPNMTLFSGNTRVEITCCRNQSFCNK 79
TFP_LU_ECD_UP cd23627
extracellular domain (ECD) found in urinary proteins (UP1-3) and similar proteins; The family ...
 22-99 5.39e-08

extracellular domain (ECD) found in urinary proteins (UP1-3) and similar proteins; The family includes UP1 (also called liver regeneration-related protein LRRG05), UP2 and UP3, which are secreted proteins containing an extracellular domain (ECD) that belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467147  Cd Length: 81  Bit Score: 46.09  E-value: 5.39e-08
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 85702097  22 EALKCFQCTLFNSKGKCLFQEPPCETQNNEVCV-LWAKFEGGRFMYGFQECSHtCVNQTLNLRNKRIEMKCCNDKSFCN 99
Cdd:cd23627   3 LALQCFRCNSLDSTGFCHVGRRICQTYPDEICAwVVVTTRDGKFVYGNQSCAE-CNGTTVEHGSLIVSTNCCSATPFCN 80
TFP_LU_ECD_PATE3 cd23579
extracellular domain (ECD) found in prostate and testis expressed protein 3 (PATE3) and ...
 21-100 6.26e-05

extracellular domain (ECD) found in prostate and testis expressed protein 3 (PATE3) and similar proteins; PATE3 (also called acrosomal vesicle protein HEL-127, or PATE-like protein DJ (PATE-DJ)) is a member of the prostate and testis expression (PATE)-like family of proteins that likely play important roles in reproductive and neuronal physiology. They are expressed mainly in the male genital tract and involved in sperm-oolemma fusion and penetration, but not sperm-zona binding. PATE3 contains an extracellular domain (ECD), which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467109  Cd Length: 80  Bit Score: 38.18  E-value: 6.26e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702097  21 AEALKCFQCTLFNSKGKCLFQEPPCETQNNEVCVLWAKFEGGRFMYGFQECSHTCVNQTLNLRNKRIEMKCCNdKSFCNK 100
Cdd:cd23579   2 ATALKCITCHLRTVSDRCRRGFGTCTAQKDESCMRLRIYQGDTLQLSYMVCQKFCRDLTYHFNNRTYVHTCCN-KDYCNF 80
TFP_LU_ECD_mPATE6_like cd23581
extracellular domain (ECD) found in Mus musculus prostate and testis expressed protein 6 ...
 21-99 5.34e-04

extracellular domain (ECD) found in Mus musculus prostate and testis expressed protein 6 (PATE6) and similar proteins; The family includes Mus musculus PATE6 and PATE7. PATE6 (also called called prostate and testis expressed 6, or PATE-like protein C) acts as nicotinic acetylcholine receptor (nAChR) regulator. The biological function of PATE7 (also called called prostate and testis expressed 7) remains unclear. Members in this family contain an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467111  Cd Length: 82  Bit Score: 35.90  E-value: 5.34e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702097  21 AEALKCFQCtLFNSKGKCLFQEPPCETQNNEVCV---LWAKFEGGRFMYGFQECSHTCVNQTLNLRNKRIEMKCCNDKSF 97
Cdd:cd23581   1 ALALQCNQC-LSYKDGECVHGKQTCTAKPGESCMirrIFSASESVTINSAERGCTKNCTSTEDISGDYTVITTCCSDFDF 79


                ..
gi 85702097  98 CN 99
Cdd:cd23581  80 CN 81
TFP_LU_ECD_PATE4 cd23580
extracellular domain (ECD) found in prostate and testis expressed protein 4 (PATE4) and ...
 22-101 6.24e-04

extracellular domain (ECD) found in prostate and testis expressed protein 4 (PATE4) and similar proteins; PATE4, also called prostate and testis expressed 4, or PATE-like protein B) is a member of the prostate and testis expression (PATE)-like family of proteins that likely play important roles in reproductive and neuronal physiology. They are expressed mainly in the male genital tract and involved in sperm-oolemma fusion and penetration, but not sperm-zona binding. PATE4 may modulate the function of nicotinic acetylcholine receptors and enhance sperm motility. PATE4 contains an extracellular domain (ECD), which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467110  Cd Length: 79  Bit Score: 35.45  E-value: 6.24e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702097  22 EALKCFQCTlfNSKG-KCLFQEPPCETQNNEVCVLWAKFEGGRFMYGFQECSHTCVNQTLNLRNKRIEMKCCNdKSFCNK 100
Cdd:cd23580   2 EGLICNVCI--YSKNsRCMSGQGRCTAKPGGSCSTISYYRGSKHLYSKHMCKYHCKEEQYYKGDLLRYTMCCE-KNLCNS 78


                .
gi 85702097 101 F 101
Cdd:cd23580  79 F 79
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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