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Conserved domains on  [gi|76257396|ref|NP_001028929|]
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cyclin-dependent kinase inhibitor 1C isoform 1 [Rattus norvegicus]

Protein Classification

cyclin-dependent kinase inhibitor( domain architecture ID 10491403)

cyclin-dependent kinase inhibitor is an important regulator of cell cycle progression

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CDI pfam02234
Cyclin-dependent kinase inhibitor; Cell cycle progression is negatively controlled by ...
 35-81 3.73e-12

Cyclin-dependent kinase inhibitor; Cell cycle progression is negatively controlled by cyclin-dependent kinases inhibitors (CDIs). CDIs are involved in cell cycle arrest at the G1 phase.


:

Pssm-ID: 460503  Cd Length: 46  Bit Score: 60.24  E-value: 3.73e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 76257396    35 LFGPVDHEELGRELRMRLAELNAEDQNRWDFNFQQDVPLrgPGRLQW 81
Cdd:pfam02234   1 LFGPVDHEELEEFFQAALREQQERFSEKWNFDFVNDTPL--PGRYEW 45
PTZ00341 super family cl31759
Ring-infected erythrocyte surface antigen; Provisional
 165-280 3.83e-05

Ring-infected erythrocyte surface antigen; Provisional


The actual alignment was detected with superfamily member PTZ00341:

Pssm-ID: 173534 [Multi-domain]  Cd Length: 1136  Bit Score: 45.55  E-value: 3.83e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76257396   165 SDPIPDVTPVATSDSTPDPIPDVATQDGEEQVPEQVSEQVSEQGEESGAEPGDELGAEPVSEQGKQQGAEPVEEKDEepv 244
Cdd:PTZ00341  932 NENVPEHLKEHAEANIEEDAEENVEEDAEENVEENVEENVEENVEENVEENVEENVEENVEENVEENVEENIEENVE--- 1008

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 76257396   245 eeqgaEPVEEKDEEPVEGQNGELVEEQDENQELKDQ 280
Cdd:PTZ00341 1009 -----ENVEENIEENVEEYDEENVEEVEENVEEYDE 1039
 
Name Accession Description Interval E-value
CDI pfam02234
Cyclin-dependent kinase inhibitor; Cell cycle progression is negatively controlled by ...
 35-81 3.73e-12

Cyclin-dependent kinase inhibitor; Cell cycle progression is negatively controlled by cyclin-dependent kinases inhibitors (CDIs). CDIs are involved in cell cycle arrest at the G1 phase.


Pssm-ID: 460503  Cd Length: 46  Bit Score: 60.24  E-value: 3.73e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 76257396    35 LFGPVDHEELGRELRMRLAELNAEDQNRWDFNFQQDVPLrgPGRLQW 81
Cdd:pfam02234   1 LFGPVDHEELEEFFQAALREQQERFSEKWNFDFVNDTPL--PGRYEW 45
PTZ00341 PTZ00341
Ring-infected erythrocyte surface antigen; Provisional
 165-280 3.83e-05

Ring-infected erythrocyte surface antigen; Provisional


Pssm-ID: 173534 [Multi-domain]  Cd Length: 1136  Bit Score: 45.55  E-value: 3.83e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76257396   165 SDPIPDVTPVATSDSTPDPIPDVATQDGEEQVPEQVSEQVSEQGEESGAEPGDELGAEPVSEQGKQQGAEPVEEKDEepv 244
Cdd:PTZ00341  932 NENVPEHLKEHAEANIEEDAEENVEEDAEENVEENVEENVEENVEENVEENVEENVEENVEENVEENVEENIEENVE--- 1008

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 76257396   245 eeqgaEPVEEKDEEPVEGQNGELVEEQDENQELKDQ 280
Cdd:PTZ00341 1009 -----ENVEENIEENVEEYDEENVEEVEENVEEYDE 1039
 
Name Accession Description Interval E-value
CDI pfam02234
Cyclin-dependent kinase inhibitor; Cell cycle progression is negatively controlled by ...
 35-81 3.73e-12

Cyclin-dependent kinase inhibitor; Cell cycle progression is negatively controlled by cyclin-dependent kinases inhibitors (CDIs). CDIs are involved in cell cycle arrest at the G1 phase.


Pssm-ID: 460503  Cd Length: 46  Bit Score: 60.24  E-value: 3.73e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 76257396    35 LFGPVDHEELGRELRMRLAELNAEDQNRWDFNFQQDVPLrgPGRLQW 81
Cdd:pfam02234   1 LFGPVDHEELEEFFQAALREQQERFSEKWNFDFVNDTPL--PGRYEW 45
PTZ00341 PTZ00341
Ring-infected erythrocyte surface antigen; Provisional
 165-280 3.83e-05

Ring-infected erythrocyte surface antigen; Provisional


Pssm-ID: 173534 [Multi-domain]  Cd Length: 1136  Bit Score: 45.55  E-value: 3.83e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76257396   165 SDPIPDVTPVATSDSTPDPIPDVATQDGEEQVPEQVSEQVSEQGEESGAEPGDELGAEPVSEQGKQQGAEPVEEKDEepv 244
Cdd:PTZ00341  932 NENVPEHLKEHAEANIEEDAEENVEEDAEENVEENVEENVEENVEENVEENVEENVEENVEENVEENVEENIEENVE--- 1008

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 76257396   245 eeqgaEPVEEKDEEPVEGQNGELVEEQDENQELKDQ 280
Cdd:PTZ00341 1009 -----ENVEENIEENVEEYDEENVEEVEENVEEYDE 1039
PTZ00341 PTZ00341
Ring-infected erythrocyte surface antigen; Provisional
 193-276 4.47e-04

Ring-infected erythrocyte surface antigen; Provisional


Pssm-ID: 173534 [Multi-domain]  Cd Length: 1136  Bit Score: 42.47  E-value: 4.47e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76257396   193 EEQVPEQVSEQVSEQGEESgAEPGDELGAEPVSEQGKQQGAEPVEEKDEEPVEE---QGAEPVEEKDEEPVEGQNGELVE 269
Cdd:PTZ00341  992 EENVEENVEENIEENVEEN-VEENIEENVEEYDEENVEEVEENVEEYDEENVEEieeNAEENVEENIEENIEEYDEENVE 1070


                  ....*..
gi 76257396   270 EQDENQE 276
Cdd:PTZ00341 1071 EIEENIE 1077
PTZ00341 PTZ00341
Ring-infected erythrocyte surface antigen; Provisional
 193-276 7.46e-04

Ring-infected erythrocyte surface antigen; Provisional


Pssm-ID: 173534 [Multi-domain]  Cd Length: 1136  Bit Score: 41.70  E-value: 7.46e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76257396   193 EEQVPEQVSEQVSEQGEESGAEPGDELGAEPVSEQGKQQGAEPVEEKDEEPVEEQGAEPVEEKdEEPVEGQNGELVEEQD 272
Cdd:PTZ00341  968 EENVEENVEENVEENVEENVEENVEENVEENVEENIEENVEENVEENIEENVEEYDEENVEEV-EENVEEYDEENVEEIE 1046


                  ....
gi 76257396   273 ENQE 276
Cdd:PTZ00341 1047 ENAE 1050
PTZ00341 PTZ00341
Ring-infected erythrocyte surface antigen; Provisional
 193-273 9.86e-04

Ring-infected erythrocyte surface antigen; Provisional


Pssm-ID: 173534 [Multi-domain]  Cd Length: 1136  Bit Score: 41.31  E-value: 9.86e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 76257396   193 EEQVPEQVSEQVSEQGEESGAEPGDEL------GAEPVSEQGKQQGAEPVEEKDEEPVEEQGAEPVEEKDEEPVEGQNGE 266
Cdd:PTZ00341 1046 EENAEENVEENIEENIEEYDEENVEEIeenieeNIEENVEENVEENVEEIEENVEENVEENAEENAEENAEENAEEYDDE 1125


                  ....*..
gi 76257396   267 LVEEQDE 273
Cdd:PTZ00341 1126 NPEEHNE 1132
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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