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Conserved domains on  [gi|85701794|ref|NP_001028464|]
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espin-like protein [Mus musculus]

Protein Classification

ankyrin repeat domain-containing protein( domain architecture ID 13838917)

ankyrin repeat (ANK) domain-containing protein mediates specific protein-protein interactions without necessarily recognizing specific primary sequences which allows for one ankyrin repeat domain to recognize and bind to a variety of intracellular substrates and may be involved in a wide array of functions

CATH:  1.25.40.20
Gene Ontology:  GO:0005515
PubMed:  33435370|15152081|17176038
SCOP:  4000366

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
97-325 1.73e-37

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 142.79  E-value: 1.73e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85701794   97 LQDQDASGVSPLHLAARFGHPALVEWLLREGHAATLETLEGALPLHHAAVSGDLTCLKLLTAAHSSgVNQRTCSGASPLY 176
Cdd:COG0666   47 LALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGAD-VNARDKDGETPLH 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85701794  177 LACQEGHLHLAQFLVkDCGADVRLRALDGMSSLHAAAAHGHYSLVVWLVtftDIG--LTARDNEGATALHFAARGGHTPI 254
Cdd:COG0666  126 LAAYNGNLEIVKLLL-EAGADVNAQDNDGNTPLHLAAANGNLEIVKLLL---EAGadVNARDNDGETPLHLAAENGHLEI 201

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 85701794  255 LDRLLLMGA-PIMRDSWGGTPLHDAAENGHMECCQTLLSHHVDPFLRDEDGYTAIDLAEYHGHQDCAQFLRE 325
Cdd:COG0666  202 VKLLLEAGAdVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLL 273
Ank_2 pfam12796
Ankyrin repeats (3 copies);
41-127 4.13e-12

Ankyrin repeats (3 copies);


:

Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 63.21  E-value: 4.13e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85701794     41 HHATRAGHLDCVKFLVQRAKLPgNQQAHNGATPVHDAAATGNLAELCWLVRDAGCGLQDQdasGVSPLHLAARFGHPALV 120
Cdd:pfam12796    2 HLAAKNGNLELVKLLLENGADA-NLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLKDN---GRTALHYAARSGHLEIV 77


                   ....*..
gi 85701794    121 EWLLREG 127
Cdd:pfam12796   78 KLLLEKG 84
Ank_4 pfam13637
Ankyrin repeats (many copies);
8-56 3.29e-05

Ankyrin repeats (many copies);


:

Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 42.26  E-value: 3.29e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 85701794      8 VASKDGDMATLERLFEAGAlRPDITDDLGAGLVHHATRAGHLDCVKFLV 56
Cdd:pfam13637    7 AAAASGHLELLRLLLEKGA-DINAVDGNGETALHFAASNGNVEVLKLLL 54
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
97-325 1.73e-37

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 142.79  E-value: 1.73e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85701794   97 LQDQDASGVSPLHLAARFGHPALVEWLLREGHAATLETLEGALPLHHAAVSGDLTCLKLLTAAHSSgVNQRTCSGASPLY 176
Cdd:COG0666   47 LALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGAD-VNARDKDGETPLH 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85701794  177 LACQEGHLHLAQFLVkDCGADVRLRALDGMSSLHAAAAHGHYSLVVWLVtftDIG--LTARDNEGATALHFAARGGHTPI 254
Cdd:COG0666  126 LAAYNGNLEIVKLLL-EAGADVNAQDNDGNTPLHLAAANGNLEIVKLLL---EAGadVNARDNDGETPLHLAAENGHLEI 201

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 85701794  255 LDRLLLMGA-PIMRDSWGGTPLHDAAENGHMECCQTLLSHHVDPFLRDEDGYTAIDLAEYHGHQDCAQFLRE 325
Cdd:COG0666  202 VKLLLEAGAdVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLL 273
Ank_2 pfam12796
Ankyrin repeats (3 copies);
209-301 1.56e-20

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 87.09  E-value: 1.56e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85701794    209 LHAAAAHGHYSLVVWLVTF-TDIGLTarDNEGATALHFAARGGHTPILdRLLLMGAPIMRDSWGGTPLHDAAENGHMECC 287
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENgADANLQ--DKNGRTALHLAAKNGHLEIV-KLLLEHADVNLKDNGRTALHYAARSGHLEIV 77

                           90
                   ....*....|....
gi 85701794    288 QTLLSHHVDPFLRD 301
Cdd:pfam12796   78 KLLLEKGADINVKD 91
Ank_2 pfam12796
Ankyrin repeats (3 copies);
41-127 4.13e-12

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 63.21  E-value: 4.13e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85701794     41 HHATRAGHLDCVKFLVQRAKLPgNQQAHNGATPVHDAAATGNLAELCWLVRDAGCGLQDQdasGVSPLHLAARFGHPALV 120
Cdd:pfam12796    2 HLAAKNGNLELVKLLLENGADA-NLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLKDN---GRTALHYAARSGHLEIV 77


                   ....*..
gi 85701794    121 EWLLREG 127
Cdd:pfam12796   78 KLLLEKG 84
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 72-311 1.53e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 61.52  E-value: 1.53e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85701794    72 TPVHDAAATGNlAELCWLVRDAGCGLQDQDASGVSPLHLAARFGHPALVEWLLREGHAATL--------ETLEGALP--- 140
Cdd:PHA02874   37 TPLIDAIRSGD-AKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIDNGVDTSIlpipciekDMIKTILDcgi 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85701794   141 ------------LHHAAVSGDLTCLKLLTAaHSSGVNQRTCSGASPLYLACQEGHLHLAQFLVKDcGADVRLRALDGMSS 208
Cdd:PHA02874  116 dvnikdaelktfLHYAIKKGDLESIKMLFE-YGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEK-GAYANVKDNNGESP 193

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85701794   209 LHAAAAHGHYSLVVWLVTFTDiGLTARDNEGATALHFAARGGHTPIldRLLLMGAPI-MRDSWGGTPLHDAAENG-HMEC 286
Cdd:PHA02874  194 LHNAAEYGDYACIKLLIDHGN-HIMNKCKNGFTPLHNAIIHNRSAI--ELLINNASInDQDIDGSTPLHHAINPPcDIDI 270

                         250       260
                  ....*....|....*....|....*
gi 85701794   287 CQTLLSHHVDPFLRDEDGYTAIDLA 311
Cdd:PHA02874  271 IDILLYHKADISIKDNKGENPIDTA 295
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 9-144 1.76e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 61.13  E-value: 1.76e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85701794     9 ASKDGDMATLERLFEAGAlRPDITDDLGAGLVHHATRAGHLDCVKFLVQRAKLpGNQQAHNGATPVHDAAATGNLAELCW 88
Cdd:PHA02874  131 AIKKGDLESIKMLFEYGA-DVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAY-ANVKDNNGESPLHNAAEYGDYACIKL 208

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 85701794    89 LVrDAGCGLQDQDASGVSPLHLAARFGHPALVewLLREGHAATLETLEGALPLHHA 144
Cdd:PHA02874  209 LI-DHGNHIMNKCKNGFTPLHNAIIHNRSAIE--LLINNASINDQDIDGSTPLHHA 261
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 139-276 6.06e-06

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 50.01  E-value: 6.06e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85701794  139 LPLHHAAVSGDLTCLKLLTAAHSSGVNQRTCSGASPLYLACQEGHLHLAQFLVKdcgADVRLRAL-------DGMSSLHA 211
Cdd:cd22192   19 SPLLLAAKENDVQAIKKLLKCPSCDLFQRGALGETALHVAALYDNLEAAVVLME---AAPELVNEpmtsdlyQGETALHI 95

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 85701794  212 AAAHGHYSLVVWLVTFTDIGLTAR----------DNE---GATALHFAARGGHTPILDRLLLMGAPI-MRDSWGGTPLH 276
Cdd:cd22192   96 AVVNQNLNLVRELIARGADVVSPRatgtffrpgpKNLiyyGEHPLSFAACVGNEEIVRLLIEHGADIrAQDSLGNTVLH 174
Ank_4 pfam13637
Ankyrin repeats (many copies);
8-56 3.29e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 42.26  E-value: 3.29e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 85701794      8 VASKDGDMATLERLFEAGAlRPDITDDLGAGLVHHATRAGHLDCVKFLV 56
Cdd:pfam13637    7 AAAASGHLELLRLLLEKGA-DINAVDGNGETALHFAASNGNVEVLKLLL 54
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 273-299 6.35e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 37.95  E-value: 6.35e-04
                            10        20
                    ....*....|....*....|....*..
gi 85701794     273 TPLHDAAENGHMECCQTLLSHHVDPFL 299
Cdd:smart00248    4 TPLHLAAENGNLEVVKLLLDKGADINA 30
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
97-325 1.73e-37

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 142.79  E-value: 1.73e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85701794   97 LQDQDASGVSPLHLAARFGHPALVEWLLREGHAATLETLEGALPLHHAAVSGDLTCLKLLTAAHSSgVNQRTCSGASPLY 176
Cdd:COG0666   47 LALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGAD-VNARDKDGETPLH 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85701794  177 LACQEGHLHLAQFLVkDCGADVRLRALDGMSSLHAAAAHGHYSLVVWLVtftDIG--LTARDNEGATALHFAARGGHTPI 254
Cdd:COG0666  126 LAAYNGNLEIVKLLL-EAGADVNAQDNDGNTPLHLAAANGNLEIVKLLL---EAGadVNARDNDGETPLHLAAENGHLEI 201

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 85701794  255 LDRLLLMGA-PIMRDSWGGTPLHDAAENGHMECCQTLLSHHVDPFLRDEDGYTAIDLAEYHGHQDCAQFLRE 325
Cdd:COG0666  202 VKLLLEAGAdVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLL 273
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
108-325 4.24e-37

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 141.63  E-value: 4.24e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85701794  108 LHLAARFGHPALVEWLLREGHAATLETLEGALPLHHAAVSGDLTCLKLLTAAHSSGVNQRTCSGASPLYLACQEGHLHLA 187
Cdd:COG0666   24 LLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIV 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85701794  188 QFLVKDcGADVRLRALDGMSSLHAAAAHGHYSLVVWLVtftDIG--LTARDNEGATALHFAARGGHTPILDRLLLMGAPI 265
Cdd:COG0666  104 KLLLEA-GADVNARDKDGETPLHLAAYNGNLEIVKLLL---EAGadVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADV 179

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 85701794  266 -MRDSWGGTPLHDAAENGHMECCQTLLSHHVDPFLRDEDGYTAIDLAEYHGHQDCAQFLRE 325
Cdd:COG0666  180 nARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLE 240
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
6-260 2.82e-32

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 127.38  E-value: 2.82e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85701794    6 ALVASKDGDMATLERLFEAGALRPDITDDLGAGLVHHATRAGHLDCVKFLVQRAKLPGNQQAHNGATPVHDAAATGNLAE 85
Cdd:COG0666   23 LLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEI 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85701794   86 LCWLVrDAGCGLQDQDASGVSPLHLAARFGHPALVEWLLREGHAATLETLEGALPLHHAAVSGDLTCLKLLtAAHSSGVN 165
Cdd:COG0666  103 VKLLL-EAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLL-LEAGADVN 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85701794  166 QRTCSGASPLYLACQEGHLHLAQFLVkDCGADVRLRALDGMSSLHAAAAHGHYSLVVWLVTFTDIgLTARDNEGATALHF 245
Cdd:COG0666  181 ARDNDGETPLHLAAENGHLEIVKLLL-EAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGAD-LNAKDKDGLTALLL 258

                        250
                 ....*....|....*
gi 85701794  246 AARGGHTPILDRLLL 260
Cdd:COG0666  259 AAAAGAALIVKLLLL 273
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
138-325 4.47e-28

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 115.44  E-value: 4.47e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85701794  138 ALPLHHAAVSGDLTCLKLLTAAHSSGVNQRTCSGASPLYLACQEGHLHLAQFLVKDCGADVRLRALDGMSSLHAAAAHGH 217
Cdd:COG0666   20 LLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGD 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85701794  218 YSLVVWLVtftDIG--LTARDNEGATALHFAARGGHTPILDRLLLMGAPI-MRDSWGGTPLHDAAENGHMECCQTLLSHH 294
Cdd:COG0666  100 LEIVKLLL---EAGadVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVnAQDNDGNTPLHLAAANGNLEIVKLLLEAG 176

                        170       180       190
                 ....*....|....*....|....*....|.
gi 85701794  295 VDPFLRDEDGYTAIDLAEYHGHQDCAQFLRE 325
Cdd:COG0666  177 ADVNARDNDGETPLHLAAENGHLEIVKLLLE 207
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
9-193 1.62e-26

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 110.81  E-value: 1.62e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85701794    9 ASKDGDMATLERLFEAGAlRPDITDDLGAGLVHHATRAGHLDCVKFLVQR-AKLpgNQQAHNGATPVHDAAATGNLAELC 87
Cdd:COG0666   94 AARNGDLEIVKLLLEAGA-DVNARDKDGETPLHLAAYNGNLEIVKLLLEAgADV--NAQDNDGNTPLHLAAANGNLEIVK 170

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85701794   88 WLVrDAGCGLQDQDASGVSPLHLAARFGHPALVEWLLREGHAATLETLEGALPLHHAAVSGDLTCLKLLTAAHsSGVNQR 167
Cdd:COG0666  171 LLL-EAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAG-ADLNAK 248

                        170       180
                 ....*....|....*....|....*.
gi 85701794  168 TCSGASPLYLACQEGHLHLAQFLVKD 193
Cdd:COG0666  249 DKDGLTALLLAAAAGAALIVKLLLLA 274
Ank_2 pfam12796
Ankyrin repeats (3 copies);
209-301 1.56e-20

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 87.09  E-value: 1.56e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85701794    209 LHAAAAHGHYSLVVWLVTF-TDIGLTarDNEGATALHFAARGGHTPILdRLLLMGAPIMRDSWGGTPLHDAAENGHMECC 287
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENgADANLQ--DKNGRTALHLAAKNGHLEIV-KLLLEHADVNLKDNGRTALHYAARSGHLEIV 77

                           90
                   ....*....|....
gi 85701794    288 QTLLSHHVDPFLRD 301
Cdd:pfam12796   78 KLLLEKGADINVKD 91
Ank_2 pfam12796
Ankyrin repeats (3 copies);
108-201 4.46e-17

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 77.08  E-value: 4.46e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85701794    108 LHLAARFGHPALVEWLLREGHAATLETLEGALPLHHAAVSGDLTCLKLLtAAHSSGvnQRTCSGASPLYLACQEGHLHLA 187
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLL-LEHADV--NLKDNGRTALHYAARSGHLEIV 77

                           90
                   ....*....|....
gi 85701794    188 QFLVkDCGADVRLR 201
Cdd:pfam12796   78 KLLL-EKGADINVK 90
Ank_2 pfam12796
Ankyrin repeats (3 copies);
243-323 2.48e-16

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 75.15  E-value: 2.48e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85701794    243 LHFAARGGHTPILDRLLLMGAPI-MRDSWGGTPLHDAAENGHMECCQTLLSH-HVDpflRDEDGYTAIDLAEYHGHQDCA 320
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADAnLQDKNGRTALHLAAKNGHLEIVKLLLEHaDVN---LKDNGRTALHYAARSGHLEIV 77


                   ...
gi 85701794    321 QFL 323
Cdd:pfam12796   78 KLL 80
Ank_2 pfam12796
Ankyrin repeats (3 copies);
175-263 5.40e-16

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 74.00  E-value: 5.40e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85701794    175 LYLACQEGHLHLAQFLVKdCGADVRLRALDGMSSLHAAAAHGHYSLVVWLVTFTDIGLtarDNEGATALHFAARGGHTPI 254
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLE-NGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNL---KDNGRTALHYAARSGHLEI 76


                   ....*....
gi 85701794    255 LDRLLLMGA 263
Cdd:pfam12796   77 VKLLLEKGA 85
Ank_2 pfam12796
Ankyrin repeats (3 copies);
75-156 4.48e-13

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 65.91  E-value: 4.48e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85701794     75 HDAAATGNLAELCWLVrDAGCGLQDQDASGVSPLHLAARFGHPALVEWLLRegHAATLETLEGALPLHHAAVSGDLTCLK 154
Cdd:pfam12796    2 HLAAKNGNLELVKLLL-ENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE--HADVNLKDNGRTALHYAARSGHLEIVK 78


                   ..
gi 85701794    155 LL 156
Cdd:pfam12796   79 LL 80
Ank_2 pfam12796
Ankyrin repeats (3 copies);
41-127 4.13e-12

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 63.21  E-value: 4.13e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85701794     41 HHATRAGHLDCVKFLVQRAKLPgNQQAHNGATPVHDAAATGNLAELCWLVRDAGCGLQDQdasGVSPLHLAARFGHPALV 120
Cdd:pfam12796    2 HLAAKNGNLELVKLLLENGADA-NLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLKDN---GRTALHYAARSGHLEIV 77


                   ....*..
gi 85701794    121 EWLLREG 127
Cdd:pfam12796   78 KLLLEKG 84
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
196-323 1.12e-11

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 66.90  E-value: 1.12e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85701794  196 ADVRLRALDGMSSLHAAAAHGHYSLVVWLVTFTDIGLTARDNEGATALHFAARGGHTPILDRLLLMGAPI-MRDSWGGTP 274
Cdd:COG0666   11 LLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADInAKDDGGNTL 90

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 85701794  275 LHDAAENGHMECCQTLLSHHVDPFLRDEDGYTAIDLAEYHGHQDCAQFL 323
Cdd:COG0666   91 LHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLL 139
Ank_4 pfam13637
Ankyrin repeats (many copies);
271-323 2.09e-10

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 56.90  E-value: 2.09e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 85701794    271 GGTPLHDAAENGHMECCQTLLSHHVDPFLRDEDGYTAIDLAEYHGHQDCAQFL 323
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLL 53
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 72-311 1.53e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 61.52  E-value: 1.53e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85701794    72 TPVHDAAATGNlAELCWLVRDAGCGLQDQDASGVSPLHLAARFGHPALVEWLLREGHAATL--------ETLEGALP--- 140
Cdd:PHA02874   37 TPLIDAIRSGD-AKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIDNGVDTSIlpipciekDMIKTILDcgi 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85701794   141 ------------LHHAAVSGDLTCLKLLTAaHSSGVNQRTCSGASPLYLACQEGHLHLAQFLVKDcGADVRLRALDGMSS 208
Cdd:PHA02874  116 dvnikdaelktfLHYAIKKGDLESIKMLFE-YGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEK-GAYANVKDNNGESP 193

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85701794   209 LHAAAAHGHYSLVVWLVTFTDiGLTARDNEGATALHFAARGGHTPIldRLLLMGAPI-MRDSWGGTPLHDAAENG-HMEC 286
Cdd:PHA02874  194 LHNAAEYGDYACIKLLIDHGN-HIMNKCKNGFTPLHNAIIHNRSAI--ELLINNASInDQDIDGSTPLHHAINPPcDIDI 270

                         250       260
                  ....*....|....*....|....*
gi 85701794   287 CQTLLSHHVDPFLRDEDGYTAIDLA 311
Cdd:PHA02874  271 IDILLYHKADISIKDNKGENPIDTA 295
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 9-144 1.76e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 61.13  E-value: 1.76e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85701794     9 ASKDGDMATLERLFEAGAlRPDITDDLGAGLVHHATRAGHLDCVKFLVQRAKLpGNQQAHNGATPVHDAAATGNLAELCW 88
Cdd:PHA02874  131 AIKKGDLESIKMLFEYGA-DVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAY-ANVKDNNGESPLHNAAEYGDYACIKL 208

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 85701794    89 LVrDAGCGLQDQDASGVSPLHLAARFGHPALVewLLREGHAATLETLEGALPLHHA 144
Cdd:PHA02874  209 LI-DHGNHIMNKCKNGFTPLHNAIIHNRSAIE--LLINNASINDQDIDGSTPLHHA 261
Ank_4 pfam13637
Ankyrin repeats (many copies);
205-259 4.05e-09

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 53.43  E-value: 4.05e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 85701794    205 GMSSLHAAAAHGHYSLVVWLV-TFTDIglTARDNEGATALHFAARGGHTPILDRLL 259
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLeKGADI--NAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_5 pfam13857
Ankyrin repeats (many copies);
263-311 7.37e-09

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 52.73  E-value: 7.37e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 85701794    263 APIMRDSWGGTPLHDAAENGHMECCQTLLSHHVDPFLRDEDGYTAIDLA 311
Cdd:pfam13857    8 DLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
Ank_4 pfam13637
Ankyrin repeats (many copies);
241-291 1.47e-08

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 51.89  E-value: 1.47e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 85701794    241 TALHFAARGGHTPILDRLLLMGAPI-MRDSWGGTPLHDAAENGHMECCQTLL 291
Cdd:pfam13637    3 TALHAAAASGHLELLRLLLEKGADInAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 13-198 1.89e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 54.61  E-value: 1.89e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85701794    13 GDMATLERLFEAGaLRPDITDDLGAGLVHHATRAGHLDCVKFLVQRAKLPgNQQAHNGATPVHDAAATGNLAELCWLVrD 92
Cdd:PHA02875   13 GELDIARRLLDIG-INPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIP-DVKYPDIESELHDAVEEGDVKAVEELL-D 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85701794    93 AGCGLQDQ-DASGVSPLHLAARFGHPALVEWLLREGHAATLETLEGALPLHHAAVSGDLTCLKLLTaAHSSGVNQRTCSG 171
Cdd:PHA02875   90 LGKFADDVfYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLI-DHKACLDIEDCCG 168

                         170       180
                  ....*....|....*....|....*..
gi 85701794   172 ASPLYLACQEGHLHLAQFLVkDCGADV 198
Cdd:PHA02875  169 CTPLIIAMAKGDIAICKMLL-DSGANI 194
PHA03095 PHA03095
ankyrin-like protein; Provisional
 69-292 2.35e-07

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 54.65  E-value: 2.35e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85701794    69 NGATPVHDAAATGNLAELCWLVRDAGCGLQDQDASGVSPLH--LAARFGHPALVEWLLREGHAATLETLEGALPLHHAAV 146
Cdd:PHA03095   82 CGFTPLHLYLYNATTLDVIKLLIKAGADVNAKDKVGRTPLHvyLSGFNINPKVIRLLLRKGADVNALDLYGMTPLAVLLK 161

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85701794   147 SGDLT--CLKLLTAAhssGVNQRTCS--GASPLYlacqeghlHLAQFLVKD---------CGADVRLRALDGMSSLHAAA 213
Cdd:PHA03095  162 SRNANveLLRLLIDA---GADVYAVDdrFRSLLH--------HHLQSFKPRarivrelirAGCDPAATDMLGNTPLHSMA 230

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85701794   214 AHG--HYSLVVWLVTfTDIGLTARDNEGATALHFAARGGHTPILDRLLLMGAPI-MRDSWGGTPLHDAAENGHMECCQTL 290
Cdd:PHA03095  231 TGSscKRSLVLPLLI-AGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADInAVSSDGNTPLSLMVRNNNGRAVRAA 309


                  ..
gi 85701794   291 LS 292
Cdd:PHA03095  310 LA 311
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 244-385 2.60e-07

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 54.52  E-value: 2.60e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85701794   244 HFAARGGHTPIldRLLLMGA--PIMRDSWGGTPLHDAAENGHMECCQTLLSHHVDPFLRDEDGYTAIDLAEYHGHQDCAQ 321
Cdd:PTZ00322   88 QLAASGDAVGA--RILLTGGadPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQ 165

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 85701794   322 FLREMSRpvrvlmtpppppfppppllaAKLSLEEERRGDSGLKSPSSATLSPVWPAQP----VPRePM 385
Cdd:PTZ00322  166 LLSRHSQ--------------------CHFELGANAKPDSFTGKPPSLEDSPISSHHPdfsaVPQ-PM 212
PHA03095 PHA03095
ankyrin-like protein; Provisional
 6-154 4.61e-07

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 53.49  E-value: 4.61e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85701794     6 ALVASKDGDMATLERLFEAGAlrpDIT--DDLGAGLVHHatragHLD-------CVKFLVQRAKLPGNQQAHnGATPVHD 76
Cdd:PHA03095  158 VLLKSRNANVELLRLLIDAGA---DVYavDDRFRSLLHH-----HLQsfkprarIVRELIRAGCDPAATDML-GNTPLHS 228

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85701794    77 AAATGNLAELcwLVRD---AGCGLQDQDASGVSPLHLAARFGHPALVEWLLREGHAATLETLEGALPLHHAAVSGDLTCL 153
Cdd:PHA03095  229 MATGSSCKRS--LVLPlliAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLSLMVRNNNGRAV 306


                  .
gi 85701794   154 K 154
Cdd:PHA03095  307 R 307
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 205-323 5.46e-07

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 53.72  E-value: 5.46e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85701794   205 GMSSLHAAAAHGHYSLVVWLVTFTdIGLTARDNEGATALHFAARGGHTPILdRLLLMGAPIMRDSWGGTPLHDAAENGHM 284
Cdd:PLN03192  558 GRTPLHIAASKGYEDCVLVLLKHA-CNVHIRDANGNTALWNAISAKHHKIF-RILYHFASISDPHAAGDLLCTAAKRNDL 635

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 85701794   285 ECCQTLLSHHVDPFLRDEDGYTAIDLAEYHGHQDCAQFL 323
Cdd:PLN03192  636 TAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLL 674
Ank_4 pfam13637
Ankyrin repeats (many copies);
72-124 9.68e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 46.50  E-value: 9.68e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 85701794     72 TPVHDAAATGNLAELCWLVrDAGCGLQDQDASGVSPLHLAARFGHPALVEWLL 124
Cdd:pfam13637    3 TALHAAAASGHLELLRLLL-EKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_4 pfam13637
Ankyrin repeats (many copies);
173-225 9.97e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 46.50  E-value: 9.97e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 85701794    173 SPLYLACQEGHLHLAQFLVKDcGADVRLRALDGMSSLHAAAAHGHYSLVVWLV 225
Cdd:pfam13637    3 TALHAAAASGHLELLRLLLEK-GADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA03095 PHA03095
ankyrin-like protein; Provisional
 92-324 1.61e-06

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 51.95  E-value: 1.61e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85701794    92 DAGCGLQDQDASGVSPLHLAARFGH-PALVEWLLREGHAATLETLEGALPLHhAAVSGDLTCLKLLTA--AHSSGVNQRT 168
Cdd:PHA03095   71 EAGADVNAPERCGFTPLHLYLYNATtLDVIKLLIKAGADVNAKDKVGRTPLH-VYLSGFNINPKVIRLllRKGADVNALD 149

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85701794   169 CSGASPL--YLACQEGHLHLAQFLVkDCGADVRLRALDGMSSLH--AAAAHGHYSLVVWLVTfTDIGLTARDNEGATALH 244
Cdd:PHA03095  150 LYGMTPLavLLKSRNANVELLRLLI-DAGADVYAVDDRFRSLLHhhLQSFKPRARIVRELIR-AGCDPAATDMLGNTPLH 227

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85701794   245 FAARGG--HTPILDRLLLMGAPI-MRDSWGGTPLHDAAENGHMECCQTLLSHHVDPFLRDEDGYTAIDLAEYHGHQDC-A 320
Cdd:PHA03095  228 SMATGSscKRSLVLPLLIAGISInARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLSLMVRNNNGRAvR 307


                  ....
gi 85701794   321 QFLR 324
Cdd:PHA03095  308 AALA 311
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 76-297 2.16e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 51.15  E-value: 2.16e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85701794    76 DAAATGNLAELCWLVrDAGCGLQDQDASGVSPLHLAARFGHPALVEWLLREGHAATLETLEGALPLHHAAVSGDLTCLKL 155
Cdd:PHA02875    8 DAILFGELDIARRLL-DIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEE 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85701794   156 LTAAHSSGVNQRTCSGASPLYLACQEGHLHLAQFLVKDcGADVRLRALDGMSSLHAAAAHGHYSLVVWLVTftdigltar 235
Cdd:PHA02875   87 LLDLGKFADDVFYKDGMTPLHLATILKKLDIMKLLIAR-GADPDIPNTDKFSPLHLAVMMGDIKGIELLID--------- 156

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 85701794   236 dnegatalhfaarggHTPILDrlllmgapiMRDSWGGTPLHDAAENGHMECCQTLLSHHVDP 297
Cdd:PHA02875  157 ---------------HKACLD---------IEDCCGCTPLIIAMAKGDIAICKMLLDSGANI 194
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 72-248 3.07e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 50.73  E-value: 3.07e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85701794    72 TPVHDAAATGNLaELCWLVRDAGCGLQDQDASGVSPLHLAARFGHPALVEWLLREGHAATLETLEGALPLHHAAVSGDLT 151
Cdd:PHA02874  126 TFLHYAIKKGDL-ESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYA 204

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85701794   152 CLKLLTaAHSSGVNQRTCSGASPLYLACqeghLH---LAQFLVKDcgADVRLRALDGMSSLHAAAAHGHYSLVVWLVTFT 228
Cdd:PHA02874  205 CIKLLI-DHGNHIMNKCKNGFTPLHNAI----IHnrsAIELLINN--ASINDQDIDGSTPLHHAINPPCDIDIIDILLYH 277

                         170       180
                  ....*....|....*....|
gi 85701794   229 DIGLTARDNEGATALHFAAR 248
Cdd:PHA02874  278 KADISIKDNKGENPIDTAFK 297
Ank_5 pfam13857
Ankyrin repeats (many copies);
224-276 3.12e-06

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 45.03  E-value: 3.12e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 85701794    224 LVTFTDIGLTARDNEGATALHFAARGGHTPILDRLLLMGAPI-MRDSWGGTPLH 276
Cdd:pfam13857    1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLnLKDEEGLTALD 54
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 39-226 3.12e-06

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 51.41  E-value: 3.12e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85701794    39 LVHHATRAGhLDCVKFLVQRAklpGNQQAHNGATPVHDAAATGNLAELCWLVRdAGCGLQDQDASGVSPLHLAARFGHPA 118
Cdd:PLN03192  498 LQHHKELHD-LNVGDLLGDNG---GEHDDPNMASNLLTVASTGNAALLEELLK-AKLDPDIGDSKGRTPLHIAASKGYED 572

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85701794   119 LVEWLLREGHAATLETLEGALPLHHAAVSGDLTCLKLLTA-AHSSGVNqrtcSGASPLYLACQEGHLHLAQFLVKDcGAD 197
Cdd:PLN03192  573 CVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRILYHfASISDPH----AAGDLLCTAAKRNDLTAMKELLKQ-GLN 647

                         170       180
                  ....*....|....*....|....*....
gi 85701794   198 VRLRALDGMSSLHAAAAHGHYSLVVWLVT 226
Cdd:PLN03192  648 VDSEDHQGATALQVAMAEDHVDMVRLLIM 676
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 3-209 3.40e-06

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 51.02  E-value: 3.40e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85701794     3 AQQALVASKDGDMATLERLFEAGaLRPDITDDLGAGLVHHATRAGHLDCVKFLVQRAklpgnqqahngatpvhdaaatgn 82
Cdd:PLN03192  526 ASNLLTVASTGNAALLEELLKAK-LDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHA----------------------- 581

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85701794    83 laelcwlvrdagCGLQDQDASGVSPLHLAARFGHPALVeWLLREGHAATLETLEGALpLHHAAVSGDLTCLKLLTAaHSS 162
Cdd:PLN03192  582 ------------CNVHIRDANGNTALWNAISAKHHKIF-RILYHFASISDPHAAGDL-LCTAAKRNDLTAMKELLK-QGL 646

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 85701794   163 GVNQRTCSGASPLYLACQEGHLHLAQFLVKDcGADVRLRAL-DGMSSL 209
Cdd:PLN03192  647 NVDSEDHQGATALQVAMAEDHVDMVRLLIMN-GADVDKANTdDDFSPT 693
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 236-328 5.12e-06

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 50.64  E-value: 5.12e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85701794   236 DNEGATALHFAARGGHTPILDRLLLMG-APIMRDSWGGTPLHDAAENGHMECCQTLLSHHVDPFLRDEDGYTAIDLAEYH 314
Cdd:PLN03192  522 DPNMASNLLTVASTGNAALLEELLKAKlDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISA 601

                          90
                  ....*....|....
gi 85701794   315 GHQDCAQFLREMSR 328
Cdd:PLN03192  602 KHHKIFRILYHFAS 615
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 118-314 5.53e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 49.96  E-value: 5.53e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85701794   118 ALVEWLLR-EGHAATLETLEGALPLHHAAVSGDLTCLKLLTAaHSSGVNQRTCSGASPLYLACQEGHLHLAQFLVK---- 192
Cdd:PHA02874   15 EAIEKIIKnKGNCINISVDETTTPLIDAIRSGDAKIVELFIK-HGADINHINTKIPHPLLTAIKIGAHDIIKLLIDngvd 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85701794   193 ------------------DCGADVRLRALDGMSSLHAAAAHGHYSLVVWLVTF-TDIGLtaRDNEGATALHFAARGGHTP 253
Cdd:PHA02874   94 tsilpipciekdmiktilDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYgADVNI--EDDNGCYPIHIAIKHNFFD 171

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 85701794   254 ILDRLLLMGAPI-MRDSWGGTPLHDAAENGHMECCQTLLSHHVDPFLRDEDGYTAIDLAEYH 314
Cdd:PHA02874  172 IIKLLLEKGAYAnVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIH 233
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 139-276 6.06e-06

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 50.01  E-value: 6.06e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85701794  139 LPLHHAAVSGDLTCLKLLTAAHSSGVNQRTCSGASPLYLACQEGHLHLAQFLVKdcgADVRLRAL-------DGMSSLHA 211
Cdd:cd22192   19 SPLLLAAKENDVQAIKKLLKCPSCDLFQRGALGETALHVAALYDNLEAAVVLME---AAPELVNEpmtsdlyQGETALHI 95

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 85701794  212 AAAHGHYSLVVWLVTFTDIGLTAR----------DNE---GATALHFAARGGHTPILDRLLLMGAPI-MRDSWGGTPLH 276
Cdd:cd22192   96 AVVNQNLNLVRELIARGADVVSPRatgtffrpgpKNLiyyGEHPLSFAACVGNEEIVRLLIEHGADIrAQDSLGNTVLH 174
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 140-278 1.80e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 48.91  E-value: 1.80e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85701794   140 PLHHAAVSGDLTCLKLLTAAHSSGVNQRTCSGASPLYLACQEGHLHLAQFLVKDCGADVRlrALDGM--SSLHAAAAHGH 217
Cdd:PHA02876  276 PLHHASQAPSLSRLVPKLLERGADVNAKNIKGETPLYLMAKNGYDTENIRTLIMLGADVN--AADRLyiTPLHQASTLDR 353

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 85701794   218 YSLVVwlVTFTDIG--LTARDNEGATALHFAARGGHTPILDRLLLMGAPIMRDSWG-GTPLHDA 278
Cdd:PHA02876  354 NKDIV--ITLLELGanVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQKiGTALHFA 415
Ank_4 pfam13637
Ankyrin repeats (many copies);
8-56 3.29e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 42.26  E-value: 3.29e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 85701794      8 VASKDGDMATLERLFEAGAlRPDITDDLGAGLVHHATRAGHLDCVKFLV 56
Cdd:pfam13637    7 AAAASGHLELLRLLLEKGA-DINAVDGNGETALHFAASNGNVEVLKLLL 54
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 98-265 3.38e-05

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 47.94  E-value: 3.38e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85701794    98 QDQDASGVSPLHLAARFGHPALVEWLLREGHAATLETLEGALPLHHAAVSGDLTCLKLLTAaHSSGVNQRTCSGASPLYL 177
Cdd:PLN03192  519 EHDDPNMASNLLTVASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLK-HACNVHIRDANGNTALWN 597

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85701794   178 ACQEGH-------LHLAQFLVKDCGADVrlraldgmssLHAAAAHGHYSLVVWLVTFtDIGLTARDNEGATALHFAARGG 250
Cdd:PLN03192  598 AISAKHhkifrilYHFASISDPHAAGDL----------LCTAAKRNDLTAMKELLKQ-GLNVDSEDHQGATALQVAMAED 666

                         170
                  ....*....|....*
gi 85701794   251 HTPILDRLLLMGAPI 265
Cdd:PLN03192  667 HVDMVRLLIMNGADV 681
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 89-296 3.71e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 47.75  E-value: 3.71e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85701794    89 LVRDAGCGLQDQDASGVSPLHLAARFGHPALVEWLLREGHAATLETLEGALPLHHAAVSGDLTCLK-------------- 154
Cdd:PHA02876  163 MLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKaiidnrsninkndl 242

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85701794   155 -LLTAAHSS-------------GVNQRTCSGASPLYLACQEGHLHLAQFLVKDCGADVRLRALDGMSSLHAAAAHGHYSL 220
Cdd:PHA02876  243 sLLKAIRNEdletslllydagfSVNSIDDCKNTPLHHASQAPSLSRLVPKLLERGADVNAKNIKGETPLYLMAKNGYDTE 322

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85701794   221 VVWLVTFTDIGLTARDNEGATALHFAArgghtpILDR-------LLLMGAPI-MRDSWGGTPLHDAAENGHMECCQTLLS 292
Cdd:PHA02876  323 NIRTLIMLGADVNAADRLYITPLHQAS------TLDRnkdivitLLELGANVnARDYCDKTPIHYAAVRNNVVIINTLLD 396


                  ....
gi 85701794   293 HHVD 296
Cdd:PHA02876  397 YGAD 400
Ank_5 pfam13857
Ankyrin repeats (many copies);
97-144 5.76e-05

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 41.56  E-value: 5.76e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 85701794     97 LQDQDASGVSPLHLAARFGHPALVEWLLREGHAATLETLEGALPLHHA 144
Cdd:pfam13857    9 LNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
Ank_5 pfam13857
Ankyrin repeats (many copies);
190-246 7.97e-05

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 41.18  E-value: 7.97e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 85701794    190 LVKDCGADVRLRALDGMSSLHAAAAHGHYSLVVWLVTFtDIGLTARDNEGATALHFA 246
Cdd:pfam13857    1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAY-GVDLNLKDEEGLTALDLA 56
Ank_4 pfam13637
Ankyrin repeats (many copies);
39-90 8.36e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 41.11  E-value: 8.36e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 85701794     39 LVHHATRAGHLDCVKFLVQrAKLPGNQQAHNGATPVHDAAATGNLAELCWLV 90
Cdd:pfam13637    4 ALHAAAASGHLELLRLLLE-KGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 235-298 1.19e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 46.04  E-value: 1.19e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 85701794   235 RDNEGATALHFAARGGHTPILDRLLLMGA-PIMRDSWGGTPLHDAAENGHMECCQTLLSHHVDPF 298
Cdd:PTZ00322  111 RDYDGRTPLHIACANGHVQVVRVLLEFGAdPTLLDKDGKTPLELAEENGFREVVQLLSRHSQCHF 175
Ank_4 pfam13637
Ankyrin repeats (many copies);
140-191 1.58e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 40.34  E-value: 1.58e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 85701794    140 PLHHAAVSGDLTCLKLLtAAHSSGVNQRTCSGASPLYLACQEGHLHLAQFLV 191
Cdd:pfam13637    4 ALHAAAASGHLELLRLL-LEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_4 pfam13637
Ankyrin repeats (many copies);
104-156 1.75e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 40.34  E-value: 1.75e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 85701794    104 GVSPLHLAARFGHPALVEWLLREGHAATLETLEGALPLHHAAVSGDLTCLKLL 156
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLL 53
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 271-302 5.24e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 38.42  E-value: 5.24e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 85701794    271 GGTPLHDAAE-NGHMECCQTLLSHHVDPFLRDE 302
Cdd:pfam00023    2 GNTPLHLAAGrRGNLEIVKLLLSKGADVNARDK 34
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 273-299 6.35e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 37.95  E-value: 6.35e-04
                            10        20
                    ....*....|....*....|....*..
gi 85701794     273 TPLHDAAENGHMECCQTLLSHHVDPFL 299
Cdd:smart00248    4 TPLHLAAENGNLEVVKLLLDKGADINA 30
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 7-192 6.97e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 43.46  E-value: 6.97e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85701794    7 LVASKDGDMATLERL--------FEAGALrpditddlGAGLVHHATRAGHLDCVKFLVQRA----KLPGNQQAHNGATPV 74
Cdd:cd22192   22 LLAAKENDVQAIKKLlkcpscdlFQRGAL--------GETALHVAALYDNLEAAVVLMEAApelvNEPMTSDLYQGETAL 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85701794   75 HDAAATGNLAelcwLVRD---AGCGLQDQDASGV--------------SPLHLAARFGHPALVEWLLREGHAATLETLEG 137
Cdd:cd22192   94 HIAVVNQNLN----LVREliaRGADVVSPRATGTffrpgpknliyygeHPLSFAACVGNEEIVRLLIEHGADIRAQDSLG 169

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 85701794  138 ALPLHHAAV-------------------SGDLTCLKLLTaahssgvNQRtcsGASPLYLACQEGHLHLAQFLVK 192
Cdd:cd22192  170 NTVLHILVLqpnktfacqmydlilsydkEDDLQPLDLVP-------NNQ---GLTPFKLAAKEGNIVMFQHLVQ 233
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 104-127 2.30e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 36.47  E-value: 2.30e-03
                           10        20
                   ....*....|....*....|....
gi 85701794    104 GVSPLHLAARFGHPALVEWLLREG 127
Cdd:pfam13606    2 GNTPLHLAARNGRLEIVKLLLENG 25
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 65-210 2.71e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 41.54  E-value: 2.71e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85701794   65 QQAHNGATPVHDAAATGNLAELCWLVRDAGCGLQDQDASGVSPLHLAARFGHPALVEWLLREG-----HAATLETLEGAL 139
Cdd:cd22192   12 QQKRISESPLLLAAKENDVQAIKKLLKCPSCDLFQRGALGETALHVAALYDNLEAAVVLMEAApelvnEPMTSDLYQGET 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85701794  140 PLHHAAVSGDLTCLKLLTAAHSSGVNQRTCS-------------GASPL-YLACQeGHLHLAQFLVKDcGADVRLRALDG 205
Cdd:cd22192   92 ALHIAVVNQNLNLVRELIARGADVVSPRATGtffrpgpknliyyGEHPLsFAACV-GNEEIVRLLIEH-GADIRAQDSLG 169


                 ....*
gi 85701794  206 MSSLH 210
Cdd:cd22192  170 NTVLH 174
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 238-265 5.81e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 35.31  E-value: 5.81e-03
                           10        20
                   ....*....|....*....|....*...
gi 85701794    238 EGATALHFAARGGHTPILDRLLLMGAPI 265
Cdd:pfam13606    1 DGNTPLHLAARNGRLEIVKLLLENGADI 28
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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