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Conserved domains on  [gi|71980924|ref|NP_001021005|]
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Nucleolar protein dao-5 [Caenorhabditis elegans]

Protein Classification

nucleolar and coiled-body phosphoprotein 1 family protein( domain architecture ID 4470)

nucleolar and coiled-body phosphoprotein 1 (NOLC1) family protein; similar to mammalian NOLC1 (also known as Nopp140) which may participate in the regulation of rRNA transcription by interacting with the largest subunit of RNA polymerase I, and to Saccharomyces cerevisiae suppressor protein Srp40 which is a weak suppressor of a mutant of the subunit AC40 of DNA dependent RNA polymerase I and III; may be a chaperone involved in nucleocytoplasmic transport

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SRP40_C super family cl04891
SRP40, C-terminal domain; This presumed domain is found at the C-terminus of the S. cerevisiae ...
 622-691 2.76e-09

SRP40, C-terminal domain; This presumed domain is found at the C-terminus of the S. cerevisiae SRP40 protein and its homologs. SRP40/nopp40 is a chaperone involved in nucleocytoplasmic transport. SRP40 is also a suppressor of mutant AC40 subunit of RNA polymerase I and III.


The actual alignment was detected with superfamily member pfam05022:

Pssm-ID: 461525  Cd Length: 75  Bit Score: 54.08  E-value: 2.76e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 71980924   622 PFRRVQMTKDSV--SEKFRNNQHDSHF--DQWGQRANESLGKVVGKAFRHEKTKKKKGSYGGGPIN-QSINSIKF 691
Cdd:pfam05022   1 PFQRVDPEDVVVfaDPRLADNSYEAKGaeDDYGEKANEDLIVTRGKGFRKEKNKKKRGSYRGGAIDtNSVNSIKF 75
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 264-611 3.45e-04

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.16  E-value: 3.45e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980924   264 AKPTSAKATPKPAAKKA--DLSSDFSDDEAPAKKTPAKAAPKPASKKAESSSDSSDDEKPAAKSTPAKTTPKPTAKKAAS 341
Cdd:PHA03247 2584 SRARRPDAPPQSARPRApvDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSR 2663

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980924   342 SSSDSSDDEKKPVAKPT------SAKATPKPAAKKADSSSDSSDDE-APAKKTPVKPTPVKIVAKKVDSSSDSSDDEKKP 414
Cdd:PHA03247 2664 PRRARRLGRAAQASSPPqrprrrAARPTVGSLTSLADPPPPPPTPEpAPHALVSATPLPPGPAAARQASPALPAAPAPPA 2743

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980924   415 TKATPvkVTPKSVTKKAAASSSDSSDDEKKPVVKQTP-----NVVPKKEKAASSSDDSSDDEKKPTAKPTPKATPKQSAK 489
Cdd:PHA03247 2744 VPAGP--ATPGGPARPARPPTTAGPPAPAPPAAPAAGpprrlTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPA 2821

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980924   490 KADSSDDSSDDEAPAKKTPAKSTPAKTAVKKEASSSSDDSSDDEKTKKKSATTPAKST-------PKTALKKAESSDSSD 562
Cdd:PHA03247 2822 ASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPArppvrrlARPAVSRSTESFALP 2901

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*....
gi 71980924   563 DDEDLPKPSKAVTPRPQRADSEESAETEESSSRTPALKAKPLATSTEKA 611
Cdd:PHA03247 2902 PDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPA 2950
 
Name Accession Description Interval E-value
SRP40_C pfam05022
SRP40, C-terminal domain; This presumed domain is found at the C-terminus of the S. cerevisiae ...
 622-691 2.76e-09

SRP40, C-terminal domain; This presumed domain is found at the C-terminus of the S. cerevisiae SRP40 protein and its homologs. SRP40/nopp40 is a chaperone involved in nucleocytoplasmic transport. SRP40 is also a suppressor of mutant AC40 subunit of RNA polymerase I and III.


Pssm-ID: 461525  Cd Length: 75  Bit Score: 54.08  E-value: 2.76e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 71980924   622 PFRRVQMTKDSV--SEKFRNNQHDSHF--DQWGQRANESLGKVVGKAFRHEKTKKKKGSYGGGPIN-QSINSIKF 691
Cdd:pfam05022   1 PFQRVDPEDVVVfaDPRLADNSYEAKGaeDDYGEKANEDLIVTRGKGFRKEKNKKKRGSYRGGAIDtNSVNSIKF 75
PHA03247 PHA03247
large tegument protein UL36; Provisional
 264-611 3.45e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.16  E-value: 3.45e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980924   264 AKPTSAKATPKPAAKKA--DLSSDFSDDEAPAKKTPAKAAPKPASKKAESSSDSSDDEKPAAKSTPAKTTPKPTAKKAAS 341
Cdd:PHA03247 2584 SRARRPDAPPQSARPRApvDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSR 2663

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980924   342 SSSDSSDDEKKPVAKPT------SAKATPKPAAKKADSSSDSSDDE-APAKKTPVKPTPVKIVAKKVDSSSDSSDDEKKP 414
Cdd:PHA03247 2664 PRRARRLGRAAQASSPPqrprrrAARPTVGSLTSLADPPPPPPTPEpAPHALVSATPLPPGPAAARQASPALPAAPAPPA 2743

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980924   415 TKATPvkVTPKSVTKKAAASSSDSSDDEKKPVVKQTP-----NVVPKKEKAASSSDDSSDDEKKPTAKPTPKATPKQSAK 489
Cdd:PHA03247 2744 VPAGP--ATPGGPARPARPPTTAGPPAPAPPAAPAAGpprrlTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPA 2821

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980924   490 KADSSDDSSDDEAPAKKTPAKSTPAKTAVKKEASSSSDDSSDDEKTKKKSATTPAKST-------PKTALKKAESSDSSD 562
Cdd:PHA03247 2822 ASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPArppvrrlARPAVSRSTESFALP 2901

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*....
gi 71980924   563 DDEDLPKPSKAVTPRPQRADSEESAETEESSSRTPALKAKPLATSTEKA 611
Cdd:PHA03247 2902 PDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPA 2950
 
Name Accession Description Interval E-value
SRP40_C pfam05022
SRP40, C-terminal domain; This presumed domain is found at the C-terminus of the S. cerevisiae ...
 622-691 2.76e-09

SRP40, C-terminal domain; This presumed domain is found at the C-terminus of the S. cerevisiae SRP40 protein and its homologs. SRP40/nopp40 is a chaperone involved in nucleocytoplasmic transport. SRP40 is also a suppressor of mutant AC40 subunit of RNA polymerase I and III.


Pssm-ID: 461525  Cd Length: 75  Bit Score: 54.08  E-value: 2.76e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 71980924   622 PFRRVQMTKDSV--SEKFRNNQHDSHF--DQWGQRANESLGKVVGKAFRHEKTKKKKGSYGGGPIN-QSINSIKF 691
Cdd:pfam05022   1 PFQRVDPEDVVVfaDPRLADNSYEAKGaeDDYGEKANEDLIVTRGKGFRKEKNKKKRGSYRGGAIDtNSVNSIKF 75
PHA03247 PHA03247
large tegument protein UL36; Provisional
 264-611 3.45e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.16  E-value: 3.45e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980924   264 AKPTSAKATPKPAAKKA--DLSSDFSDDEAPAKKTPAKAAPKPASKKAESSSDSSDDEKPAAKSTPAKTTPKPTAKKAAS 341
Cdd:PHA03247 2584 SRARRPDAPPQSARPRApvDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSR 2663

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980924   342 SSSDSSDDEKKPVAKPT------SAKATPKPAAKKADSSSDSSDDE-APAKKTPVKPTPVKIVAKKVDSSSDSSDDEKKP 414
Cdd:PHA03247 2664 PRRARRLGRAAQASSPPqrprrrAARPTVGSLTSLADPPPPPPTPEpAPHALVSATPLPPGPAAARQASPALPAAPAPPA 2743

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980924   415 TKATPvkVTPKSVTKKAAASSSDSSDDEKKPVVKQTP-----NVVPKKEKAASSSDDSSDDEKKPTAKPTPKATPKQSAK 489
Cdd:PHA03247 2744 VPAGP--ATPGGPARPARPPTTAGPPAPAPPAAPAAGpprrlTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPA 2821

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980924   490 KADSSDDSSDDEAPAKKTPAKSTPAKTAVKKEASSSSDDSSDDEKTKKKSATTPAKST-------PKTALKKAESSDSSD 562
Cdd:PHA03247 2822 ASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPArppvrrlARPAVSRSTESFALP 2901

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*....
gi 71980924   563 DDEDLPKPSKAVTPRPQRADSEESAETEESSSRTPALKAKPLATSTEKA 611
Cdd:PHA03247 2902 PDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPA 2950
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 285-397 1.95e-03

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 41.80  E-value: 1.95e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71980924   285 DFSDDEAPAKKTPAKAAPKPASKKAESSSDSSDDEKPAAKSTPAKTTPKPTakkaassssdssddeKKPVAKPTSAKATP 364
Cdd:PRK12270   31 EFFADYGPGSTAAPTAAAAAAAAAASAPAAAPAAKAPAAPAPAPPAAAAPA---------------APPKPAAAAAAAAA 95

                          90       100       110
                  ....*....|....*....|....*....|...
gi 71980924   365 KPAAKKADSSSDSSDDEAPAKKTPVKPTPVKIV 397
Cdd:PRK12270   96 PAAPPAAAAAAAPAAAAVEDEVTPLRGAAAAVA 128
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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