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Conserved domains on  [gi|70887745|ref|NP_001020719|]
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keratocan precursor [Danio rerio]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 12183199)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
74-297 6.29e-19

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 87.30  E-value: 6.29e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887745  74 YLYLQNNLIDVLSAnALRNATQLKWINLNRNKITTEGlevDALRAMSNLVHLYMEDNLLSSIPSPLPA--KLEQLRLSRN 151
Cdd:COG4886 117 SLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDLP---EPLGNLTNLKSLDLSNNQLTDLPEELGNltNLKELDLSNN 192

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887745 152 KISKIPPgVFSGMGHLTLLDLQSNKLQDdavTEVSLKGLNNLIQINLAKNQLNSMP-LGLPPTTTQIFLDGNNIEKIPAE 230
Cdd:COG4886 193 QITDLPE-PLGNLTNLEELDLSGNQLTD---LPEPLANLTNLETLDLSNNQLTDLPeLGNLTNLEELDLSNNQLTDLPPL 268

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 70887745 231 yfKGLPKVASLRLNRNKLANGGIpKNVFNLSSILDLQLSHNQLTEVPVISSGLEHLHLDHNKIKSVN 297
Cdd:COG4886 269 --ANLTNLKTLDLSNNQLTDLKL-KELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKG 332
LRRNT smart00013
Leucine rich repeat N-terminal domain;
40-74 2.78e-07

Leucine rich repeat N-terminal domain;


:

Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 46.16  E-value: 2.78e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 70887745     40 ACPKECNCPpnfPNAVYCDNKGLKSIPV-IPPYTWY 74
Cdd:smart00013   1 ACPAPCNCS---GTAVDCSGRGLTEVPLdLPPDTTL 33
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
74-297 6.29e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 87.30  E-value: 6.29e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887745  74 YLYLQNNLIDVLSAnALRNATQLKWINLNRNKITTEGlevDALRAMSNLVHLYMEDNLLSSIPSPLPA--KLEQLRLSRN 151
Cdd:COG4886 117 SLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDLP---EPLGNLTNLKSLDLSNNQLTDLPEELGNltNLKELDLSNN 192

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887745 152 KISKIPPgVFSGMGHLTLLDLQSNKLQDdavTEVSLKGLNNLIQINLAKNQLNSMP-LGLPPTTTQIFLDGNNIEKIPAE 230
Cdd:COG4886 193 QITDLPE-PLGNLTNLEELDLSGNQLTD---LPEPLANLTNLETLDLSNNQLTDLPeLGNLTNLEELDLSNNQLTDLPPL 268

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 70887745 231 yfKGLPKVASLRLNRNKLANGGIpKNVFNLSSILDLQLSHNQLTEVPVISSGLEHLHLDHNKIKSVN 297
Cdd:COG4886 269 --ANLTNLKTLDLSNNQLTDLKL-KELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKG 332
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
105-291 1.78e-13

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 71.65  E-value: 1.78e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887745  105 KITTEGLEVDALRAM-----SNLVHLYMEDNLLSSIPSPLPAKLEQLRLSRNKISKIPPGVFSGmghLTLLDLQSNKLQd 179
Cdd:PRK15370 200 QITTLILDNNELKSLpenlqGNIKTLYANSNQLTSIPATLPDTIQEMELSINRITELPERLPSA---LQSLDLFHNKIS- 275

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887745  180 dAVTEVSLKGLNNLiqiNLAKNQLNSMPLGLPPTTTQIFLDGNNIEKIPAEYFKGLpkvASLRLNRNKLAN--GGIPKNV 257
Cdd:PRK15370 276 -CLPENLPEELRYL---SVYDNSIRTLPAHLPSGITHLNVQSNSLTALPETLPPGL---KTLEAGENALTSlpASLPPEL 348

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 70887745  258 FNLSsildlqLSHNQLTEVP-VISSGLEHLHLDHN 291
Cdd:PRK15370 349 QVLD------VSKNQITVLPeTLPPTITTLDVSRN 377
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 75-206 8.15e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 58.26  E-value: 8.15e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887745  75 LYLQNNLIDVLsaNALRNATQLKWINLNRNKITTegleVDALRAMSNLVHLYMEDNLLSSIP--SPLPaKLEQLRLSRNK 152
Cdd:cd21340   7 LYLNDKNITKI--DNLSLCKNLKVLYLYDNKITK----IENLEFLTNLTHLYLQNNQIEKIEnlENLV-NLKKLYLGGNR 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887745 153 ISKI-------------------PPGV------FSGMGH---LTLLDLQSNKLQDDAvtevSLKGLNNLIQINLAKNQLN 204
Cdd:cd21340  80 ISVVeglenltnleelhienqrlPPGEkltfdpRSLAALsnsLRVLNISGNNIDSLE----PLAPLRNLEQLDASNNQIS 155


                ..
gi 70887745 205 SM 206
Cdd:cd21340 156 DL 157
LRRNT smart00013
Leucine rich repeat N-terminal domain;
40-74 2.78e-07

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 46.16  E-value: 2.78e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 70887745     40 ACPKECNCPpnfPNAVYCDNKGLKSIPV-IPPYTWY 74
Cdd:smart00013   1 ACPAPCNCS---GTAVDCSGRGLTEVPLdLPPDTTL 33
LRR_8 pfam13855
Leucine rich repeat;
142-203 4.40e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 46.36  E-value: 4.40e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 70887745   142 KLEQLRLSRNKISKIPPGVFSGMGHLTLLDLQSNKLQDdaVTEVSLKGLNNLIQINLAKNQL 203
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTT--LSPGAFSGLPSLRYLDLSGNRL 61
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 40-70 2.69e-05

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 40.69  E-value: 2.69e-05
                          10        20        30
                  ....*....|....*....|....*....|.
gi 70887745    40 ACPKECNCPPNfpnAVYCDNKGLKSIPVIPP 70
Cdd:pfam01462   1 ACPVPCHCSAT---VVNCSDRGLTAVPRDLP 28
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
74-297 6.29e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 87.30  E-value: 6.29e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887745  74 YLYLQNNLIDVLSAnALRNATQLKWINLNRNKITTEGlevDALRAMSNLVHLYMEDNLLSSIPSPLPA--KLEQLRLSRN 151
Cdd:COG4886 117 SLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDLP---EPLGNLTNLKSLDLSNNQLTDLPEELGNltNLKELDLSNN 192

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887745 152 KISKIPPgVFSGMGHLTLLDLQSNKLQDdavTEVSLKGLNNLIQINLAKNQLNSMP-LGLPPTTTQIFLDGNNIEKIPAE 230
Cdd:COG4886 193 QITDLPE-PLGNLTNLEELDLSGNQLTD---LPEPLANLTNLETLDLSNNQLTDLPeLGNLTNLEELDLSNNQLTDLPPL 268

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 70887745 231 yfKGLPKVASLRLNRNKLANGGIpKNVFNLSSILDLQLSHNQLTEVPVISSGLEHLHLDHNKIKSVN 297
Cdd:COG4886 269 --ANLTNLKTLDLSNNQLTDLKL-KELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKG 332
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
72-328 7.81e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 86.91  E-value: 7.81e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887745  72 TWYLYLQNNLIDVLSANALRNATQLKWINLNRNKITTEGLEVDALRAMSNLVHLYMEDNLLSSIPSplpaKLEQLRLSRN 151
Cdd:COG4886  48 LLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLT----NLESLDLSGN 123

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887745 152 KISKIPPGvFSGMGHLTLLDLQSNKLQDdavTEVSLKGLNNLIQINLAKNQLNSMPLGLPPTT--TQIFLDGNNIEKIPA 229
Cdd:COG4886 124 QLTDLPEE-LANLTNLKELDLSNNQLTD---LPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTnlKELDLSNNQITDLPE 199

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887745 230 EyFKGLPKVASLRLNRNKLANggIPKNVFNLSSILDLQLSHNQLTEVPVIS--SGLEHLHLDHNKIKSVNSSdicppgvl 307
Cdd:COG4886 200 P-LGNLTNLEELDLSGNQLTD--LPEPLANLTNLETLDLSNNQLTDLPELGnlTNLEELDLSNNQLTDLPPL-------- 268

                       250       260
                ....*....|....*....|.
gi 70887745 308 ddhleEKSPRLRYLRLDGNEI 328
Cdd:COG4886 269 -----ANLTNLKTLDLSNNQL 284
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
77-297 7.89e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 86.91  E-value: 7.89e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887745  77 LQNNLIDVLSANALRNATQLKWINLNRNkitteglevDALRAMSNLVHLYMEDNLLSSIPSPLPA--KLEQLRLSRNKIS 154
Cdd:COG4886  79 LLLLSLLLLGLTDLGDLTNLTELDLSGN---------EELSNLTNLESLDLSGNQLTDLPEELANltNLKELDLSNNQLT 149

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887745 155 KIPPgVFSGMGHLTLLDLQSNKLQDDAVtevSLKGLNNLIQINLAKNQLNSMP--LGLPPTTTQIFLDGNNIEKIPAEyF 232
Cdd:COG4886 150 DLPE-PLGNLTNLKSLDLSNNQLTDLPE---ELGNLTNLKELDLSNNQITDLPepLGNLTNLEELDLSGNQLTDLPEP-L 224

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 70887745 233 KGLPKVASLRLNRNKLANggIPkNVFNLSSILDLQLSHNQLTEVPVIS--SGLEHLHLDHNKIKSVN 297
Cdd:COG4886 225 ANLTNLETLDLSNNQLTD--LP-ELGNLTNLEELDLSNNQLTDLPPLAnlTNLKTLDLSNNQLTDLK 288
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
105-291 1.78e-13

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 71.65  E-value: 1.78e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887745  105 KITTEGLEVDALRAM-----SNLVHLYMEDNLLSSIPSPLPAKLEQLRLSRNKISKIPPGVFSGmghLTLLDLQSNKLQd 179
Cdd:PRK15370 200 QITTLILDNNELKSLpenlqGNIKTLYANSNQLTSIPATLPDTIQEMELSINRITELPERLPSA---LQSLDLFHNKIS- 275

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887745  180 dAVTEVSLKGLNNLiqiNLAKNQLNSMPLGLPPTTTQIFLDGNNIEKIPAEYFKGLpkvASLRLNRNKLAN--GGIPKNV 257
Cdd:PRK15370 276 -CLPENLPEELRYL---SVYDNSIRTLPAHLPSGITHLNVQSNSLTALPETLPPGL---KTLEAGENALTSlpASLPPEL 348

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 70887745  258 FNLSsildlqLSHNQLTEVP-VISSGLEHLHLDHN 291
Cdd:PRK15370 349 QVLD------VSKNQITVLPeTLPPTITTLDVSRN 377
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
72-328 1.71e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 68.04  E-value: 1.71e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887745  72 TWYLYLQNNLIDVLSANALRNATQLKWINLNRNKITTEGLEVDALRAMSNLVHLYMEDNLLSSIPSPLPAKLEQLRLSRN 151
Cdd:COG4886   3 LLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLL 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887745 152 KISKIPPGVFSGMGHLTLLDLQSNKlqddavtevSLKGLNNLIQINLAKNQLNSMPLGLPPTT--TQIFLDGNNIEKIPA 229
Cdd:COG4886  83 SLLLLGLTDLGDLTNLTELDLSGNE---------ELSNLTNLESLDLSGNQLTDLPEELANLTnlKELDLSNNQLTDLPE 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887745 230 EyFKGLPKVASLRLNRNKLANggIPKNVFNLSSILDLQLSHNQLTEVP-VIS--SGLEHLHLDHNKIKSVnssdicpPGV 306
Cdd:COG4886 154 P-LGNLTNLKSLDLSNNQLTD--LPEELGNLTNLKELDLSNNQITDLPePLGnlTNLEELDLSGNQLTDL-------PEP 223

                       250       260
                ....*....|....*....|..
gi 70887745 307 LddhleEKSPRLRYLRLDGNEI 328
Cdd:COG4886 224 L-----ANLTNLETLDLSNNQL 240
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
28-249 5.38e-12

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 67.03  E-value: 5.38e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887745   28 EIPYEHLMSQLQACPKECNCPPNFPNAVYCDNKGLKSIPV-IPPYTWYLYLQNNLIDVLSANALRNatqLKWINLNRNKI 106
Cdd:PRK15370 156 EAPAKEAANREEAVQRMRDCLKNNKTELRLKILGLTTIPAcIPEQITTLILDNNELKSLPENLQGN---IKTLYANSNQL 232

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887745  107 TT---------EGLEVDALRAM-------SNLVHLYMEDNLLSSIPSPLPAKLEQLRLSRNKISKIPPGVFSGMGHLtll 170
Cdd:PRK15370 233 TSipatlpdtiQEMELSINRITelperlpSALQSLDLFHNKISCLPENLPEELRYLSVYDNSIRTLPAHLPSGITHL--- 309

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887745  171 DLQSNKLQ----------------DDAVTEVSLKGLNNLIQINLAKNQLNSMPLGLPPTTTQIFLDGNNIEKIPaeyfKG 234
Cdd:PRK15370 310 NVQSNSLTalpetlppglktleagENALTSLPASLPPELQVLDVSKNQITVLPETLPPTITTLDVSRNALTNLP----EN 385

                        250
                 ....*....|....*.
gi 70887745  235 LPKVAS-LRLNRNKLA 249
Cdd:PRK15370 386 LPAALQiMQASRNNLV 401
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
74-293 1.15e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 65.34  E-value: 1.15e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887745  74 YLYLQNNLIDVLSAnALRNATQLKWINLNRNKITTEGLEvdaLRAMSNLVHLYMEDNLLSSIP--SPLPaKLEQLRLSRN 151
Cdd:COG4886 186 ELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLTDLPEP---LANLTNLETLDLSNNQLTDLPelGNLT-NLEELDLSNN 260

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887745 152 KISKIPPgvFSGMGHLTLLDLQSNKLQDDAVTEVSLKGLNNLIQINLAKNQLNSMPLGLPPTTTQIFLDGNNIEKIPAEY 231
Cdd:COG4886 261 QLTDLPP--LANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLT 338

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 70887745 232 FKGLPKVASLRLNRNKLANGGIPKNVFNLSSILDLQLSHNQLTEVPVISSGLEHLHLDHNKI 293
Cdd:COG4886 339 TLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGV 400
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 96-336 2.57e-10

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 61.79  E-value: 2.57e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887745   96 LKWINLNRNKITTeGLEVDALRAMSNLVHLYMEDNLLS-SIPSPLPAKLEQLRLSRNKIS-KIPP--GVFSgmgHLTLLD 171
Cdd:PLN00113  95 IQTINLSNNQLSG-PIPDDIFTTSSSLRYLNLSNNNFTgSIPRGSIPNLETLDLSNNMLSgEIPNdiGSFS---SLKVLD 170

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887745  172 LQSNKLQDDavTEVSLKGLNNLIQINLAKNQL-NSMP--LGLPPTTTQIFLDGNNIE-KIPAEY---------------- 231
Cdd:PLN00113 171 LGGNVLVGK--IPNSLTNLTSLEFLTLASNQLvGQIPreLGQMKSLKWIYLGYNNLSgEIPYEIggltslnhldlvynnl 248

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887745  232 -------FKGLPKVASLRLNRNKLAnGGIPKNVFNLSSILDLQLSHNQLT-EVPVISSGLEHLHLDHnkIKSVNSSDICP 303
Cdd:PLN00113 249 tgpipssLGNLKNLQYLFLYQNKLS-GPIPPSIFSLQKLISLDLSDNSLSgEIPELVIQLQNLEILH--LFSNNFTGKIP 325

                        250       260       270
                 ....*....|....*....|....*....|...
gi 70887745  304 PGVlddhleEKSPRLRYLRLDGNEIQPPIPREL 336
Cdd:PLN00113 326 VAL------TSLPRLQVLQLWSNKFSGEIPKNL 352
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 75-206 8.15e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 58.26  E-value: 8.15e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887745  75 LYLQNNLIDVLsaNALRNATQLKWINLNRNKITTegleVDALRAMSNLVHLYMEDNLLSSIP--SPLPaKLEQLRLSRNK 152
Cdd:cd21340   7 LYLNDKNITKI--DNLSLCKNLKVLYLYDNKITK----IENLEFLTNLTHLYLQNNQIEKIEnlENLV-NLKKLYLGGNR 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887745 153 ISKI-------------------PPGV------FSGMGH---LTLLDLQSNKLQDDAvtevSLKGLNNLIQINLAKNQLN 204
Cdd:cd21340  80 ISVVeglenltnleelhienqrlPPGEkltfdpRSLAALsnsLRVLNISGNNIDSLE----PLAPLRNLEQLDASNNQIS 155


                ..
gi 70887745 205 SM 206
Cdd:cd21340 156 DL 157
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 79-343 1.22e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 59.86  E-value: 1.22e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887745   79 NNLIDVLSAnALRNATQLKWINLNRNKITteGLEVDALRAMSNLVHLYMEDNLLSSIPSPLPAKLEQLRL----SRNKIS 154
Cdd:PLN00113 246 NNLTGPIPS-SLGNLKNLQYLFLYQNKLS--GPIPPSIFSLQKLISLDLSDNSLSGEIPELVIQLQNLEIlhlfSNNFTG 322

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887745  155 KIPPGVFSgMGHLTLLDLQSNKLQDDavTEVSLKGLNNLIQINLAKNQL---------------------NSMPLGLPPT 213
Cdd:PLN00113 323 KIPVALTS-LPRLQVLQLWSNKFSGE--IPKNLGKHNNLTVLDLSTNNLtgeipeglcssgnlfklilfsNSLEGEIPKS 399

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887745  214 TT------QIFLDGNNIE-KIPAEYFKgLPKVASLRLNRNKLAnGGIPKNVFNLSSILDLQLSHNQLT-EVPVI--SSGL 283
Cdd:PLN00113 400 LGacrslrRVRLQDNSFSgELPSEFTK-LPLVYFLDISNNNLQ-GRINSRKWDMPSLQMLSLARNKFFgGLPDSfgSKRL 477

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887745  284 EHLHLDHNKIksvnsSDICPPGVLddhleeKSPRLRYLRLDGNEIQPPIPRELMTCFRLL 343
Cdd:PLN00113 478 ENLDLSRNQF-----SGAVPRKLG------SLSELMQLKLSENKLSGEIPDELSSCKKLV 526
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 119-328 1.42e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 57.49  E-value: 1.42e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887745 119 MSNLVHLYMEDNLLSSIPSPLPAK-LEQLRLSRNKISKIPPgvFSGMGHLTLLDLQSNKLQddavtevSLKGLNNLiqIN 197
Cdd:cd21340   1 LKRITHLYLNDKNITKIDNLSLCKnLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIE-------KIENLENL--VN 69

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887745 198 LAKnqlnsmplglpptttqIFLDGNNIEKIpaEYFKGLPKVASLRLNRNKLANG-GIPKNVFNLSSILD----LQLSHNQ 272
Cdd:cd21340  70 LKK----------------LYLGGNRISVV--EGLENLTNLEELHIENQRLPPGeKLTFDPRSLAALSNslrvLNISGNN 131

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 70887745 273 LTEVPVIS--SGLEHLHLDHNKIKSVNssDICppgvlddHLEEKSPRLRYLRLDGNEI 328
Cdd:cd21340 132 IDSLEPLAplRNLEQLDASNNQISDLE--ELL-------DLLSSWPSLRELDLTGNPV 180
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 142-273 4.98e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 57.94  E-value: 4.98e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887745  142 KLEQLRLSRNKISKIPPGVFSGMGHLTLLDLQSNKLQDDAVTEVSlkGLNNLIQINLAKNQLNSmplglpptttqifldg 221
Cdd:PLN00113 476 RLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELS--SCKKLVSLDLSHNQLSG---------------- 537

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 70887745  222 nnieKIPAEyFKGLPKVASLRLNRNKLAnGGIPKNVFNLSSILDLQLSHNQL 273
Cdd:PLN00113 538 ----QIPAS-FSEMPVLSQLDLSQNQLS-GEIPKNLGNVESLVQVNISHNHL 583
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 75-201 1.33e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 54.41  E-value: 1.33e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887745  75 LYLQNNLIDVLsaNALRNATQLKWINLNRNKITT-EGLEvdalrAMSNLVHLYMEDNLLSS----IPSP-----LPAKLE 144
Cdd:cd21340  51 LYLQNNQIEKI--ENLENLVNLKKLYLGGNRISVvEGLE-----NLTNLEELHIENQRLPPgeklTFDPrslaaLSNSLR 123

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 70887745 145 QLRLSRNKISKIPPgvFSGMGHLTLLDLQSNKLQDDAVTEVSLKGLNNLIQINLAKN 201
Cdd:cd21340 124 VLNISGNNIDSLEP--LAPLRNLEQLDASNNQISDLEELLDLLSSWPSLRELDLTGN 178
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
130-342 1.34e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 56.10  E-value: 1.34e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887745 130 NLLSSIPSPLPAKLEQLRLSRNKISKIPPGVFSGMGHLTLLDLQSNKLQDDAVTEVSLKGLNNLIQINLAKNQlnsmPLG 209
Cdd:COG4886  35 LALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE----ELS 110

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887745 210 LPPTTTQIFLDGNNIEKIPAEyFKGLPKVASLRLNRNKLANggIPKNVFNLSSILDLQLSHNQLTEVPVISSG---LEHL 286
Cdd:COG4886 111 NLTNLESLDLSGNQLTDLPEE-LANLTNLKELDLSNNQLTD--LPEPLGNLTNLKSLDLSNNQLTDLPEELGNltnLKEL 187

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 70887745 287 HLDHNKIKSVnssdicpPGVLddhleEKSPRLRYLRLDGNEIQpPIPRELMTCFRL 342
Cdd:COG4886 188 DLSNNQITDL-------PEPL-----GNLTNLEELDLSGNQLT-DLPEPLANLTNL 230
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
120-307 9.01e-08

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 53.63  E-value: 9.01e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887745  120 SNLVHLYMEDNLLSSIPSpLPAKLEQLRLSRNKISKIP---PGVFSgmghltlLDLQSNKLqddavteVSLKGL-NNLIQ 195
Cdd:PRK15387 222 AHITTLVIPDNNLTSLPA-LPPELRTLEVSGNQLTSLPvlpPGLLE-------LSIFSNPL-------THLPALpSGLCK 286

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887745  196 INLAKNQLNSMPLgLPPTTTQIFLDGNNIEKIPA------------EYFKGLPKVAS----LRLNRNKLAN-GGIPKNVF 258
Cdd:PRK15387 287 LWIFGNQLTSLPV-LPPGLQELSVSDNQLASLPAlpselcklwaynNQLTSLPTLPSglqeLSVSDNQLASlPTLPSELY 365

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 70887745  259 NL--------------SSILDLQLSHNQLTEVPVISSGLEHLHLDHNKIKSVnssDICPPGVL 307
Cdd:PRK15387 366 KLwaynnrltslpalpSGLKELIVSGNRLTSLPVLPSELKELMVSGNRLTSL---PMLPSGLL 425
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
28-165 9.99e-08

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 53.55  E-value: 9.99e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887745   28 EIPyEHLMSQLQACPKECN----CPPNFPN-----AVYCDNkgLKSIPV-IPPYTWYLYLQNNLIDVLSA---------- 87
Cdd:PRK15370 255 ELP-ERLPSALQSLDLFHNkiscLPENLPEelrylSVYDNS--IRTLPAhLPSGITHLNVQSNSLTALPEtlppglktle 331

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887745   88 ---NALRN-----ATQLKWINLNRNKITT--EGLEvdalramSNLVHLYMEDNLLSSIPSPLPAKLEQLRLSRNKISKIP 157
Cdd:PRK15370 332 ageNALTSlpaslPPELQVLDVSKNQITVlpETLP-------PTITTLDVSRNALTNLPENLPAALQIMQASRNNLVRLP 404

                        170
                 ....*....|
gi 70887745  158 PGV--FSGMG 165
Cdd:PRK15370 405 ESLphFRGEG 414
LRRNT smart00013
Leucine rich repeat N-terminal domain;
40-74 2.78e-07

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 46.16  E-value: 2.78e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 70887745     40 ACPKECNCPpnfPNAVYCDNKGLKSIPV-IPPYTWY 74
Cdd:smart00013   1 ACPAPCNCS---GTAVDCSGRGLTEVPLdLPPDTTL 33
LRR_8 pfam13855
Leucine rich repeat;
142-203 4.40e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 46.36  E-value: 4.40e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 70887745   142 KLEQLRLSRNKISKIPPGVFSGMGHLTLLDLQSNKLQDdaVTEVSLKGLNNLIQINLAKNQL 203
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTT--LSPGAFSGLPSLRYLDLSGNRL 61
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
46-301 8.11e-07

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 50.93  E-value: 8.11e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887745   46 NCPPNFPNAVYCDNKGLKSIPVIPPYTWYLYLQNNLIDVLSANAlrnaTQLKWINLNRNKITteglEVDALRamSNLVHL 125
Cdd:PRK15387 218 DCLPAHITTLVIPDNNLTSLPALPPELRTLEVSGNQLTSLPVLP----PGLLELSIFSNPLT----HLPALP--SGLCKL 287

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887745  126 YMEDNLLSSIPSpLPAKLEQLRLSRNKISKIPP------GVFSGMGHLTLLDLQSNKLQDDAVTEVSLKGL----NNLIQ 195
Cdd:PRK15387 288 WIFGNQLTSLPV-LPPGLQELSVSDNQLASLPAlpselcKLWAYNNQLTSLPTLPSGLQELSVSDNQLASLptlpSELYK 366

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887745  196 INLAKNQLNSMPlGLPPTTTQIFLDGNNIEKIPAeyfkgLPkvaslrlnrnklanggipknvfnlSSILDLQLSHNQLTE 275
Cdd:PRK15387 367 LWAYNNRLTSLP-ALPSGLKELIVSGNRLTSLPV-----LP------------------------SELKELMVSGNRLTS 416

                        250       260
                 ....*....|....*....|....*.
gi 70887745  276 VPVISSGLEHLHLDHNKIKSVNSSDI 301
Cdd:PRK15387 417 LPMLPSGLLSLSVYRNQLTRLPESLI 442
LRR_8 pfam13855
Leucine rich repeat;
94-177 1.25e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.21  E-value: 1.25e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887745    94 TQLKWINLNRNKITteGLEVDALRAMSNLVHLYmednllssipsplpakleqlrLSRNKISKIPPGVFSGMGHLTLLDLQ 173
Cdd:pfam13855   1 PNLRSLDLSNNRLT--SLDDGAFKGLSNLKVLD---------------------LSNNLLTTLSPGAFSGLPSLRYLDLS 57


                  ....
gi 70887745   174 SNKL 177
Cdd:pfam13855  58 GNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 99-293 3.21e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 49.08  E-value: 3.21e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887745   99 INLNRNKITteGLEVDALRAMSNLVHLYMEDNLL-SSIPSPLPA--KLEQLRLSRNKISKIPPGVFSGMGHLTLLDLQSN 175
Cdd:PLN00113 361 LDLSTNNLT--GEIPEGLCSSGNLFKLILFSNSLeGEIPKSLGAcrSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNN 438

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887745  176 KLQDDavTEVSLKGLNNLIQINLAKNQLNSmplGLPPTT-----TQIFLDGNNIEKIPAEYFKGLPKVASLRLNRNKLAn 250
Cdd:PLN00113 439 NLQGR--INSRKWDMPSLQMLSLARNKFFG---GLPDSFgskrlENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLS- 512

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 70887745  251 GGIPKNVFNLSSILDLQLSHNQLT--------EVPVISsgleHLHLDHNKI 293
Cdd:PLN00113 513 GEIPDELSSCKKLVSLDLSHNQLSgqipasfsEMPVLS----QLDLSQNQL 559
LRR_8 pfam13855
Leucine rich repeat;
74-132 3.36e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.05  E-value: 3.36e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 70887745    74 YLYLQNNLIDVLSANALRNATQLKWINLNRNKITTegLEVDALRAMSNLVHLYMEDNLL 132
Cdd:pfam13855   5 SLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTT--LSPGAFSGLPSLRYLDLSGNRL 61
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 40-70 2.69e-05

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 40.69  E-value: 2.69e-05
                          10        20        30
                  ....*....|....*....|....*....|.
gi 70887745    40 ACPKECNCPPNfpnAVYCDNKGLKSIPVIPP 70
Cdd:pfam01462   1 ACPVPCHCSAT---VVNCSDRGLTAVPRDLP 28
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 75-321 5.04e-05

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 44.78  E-value: 5.04e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887745  75 LYLQNNLIDVLsANALRNATQLKWINLNRNKITTEGLE--VDALRAMSNLVHL-----YMEDNLLSSIPSPL--PAKLEQ 145
Cdd:COG5238 190 NQIGDEGIEEL-AEALTQNTTVTTLWLKRNPIGDEGAEilAEALKGNKSLTTLdlsnnQIGDEGVIALAEALknNTTVET 268

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887745 146 LRLSRNKISKipPGV------FSGMGHLTLLDLQSNKLQDDAVTEV--SLKGLNNLIQINLAKNQLnsmplglpptttqi 217
Cdd:COG5238 269 LYLSGNQIGA--EGAialakaLQGNTTLTSLDLSVNRIGDEGAIALaeGLQGNKTLHTLNLAYNGI-------------- 332

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887745 218 fldGNNIEKIPAEYFKGLPKVASLRLNRNKLANGG---IPKNVFNLSSILDLQLSHNQLTEVpvissGLEHL--HLDHNK 292
Cdd:COG5238 333 ---GAQGAIALAKALQENTTLHSLDLSDNQIGDEGaiaLAKYLEGNTTLRELNLGKNNIGKQ-----GAEALidALQTNR 404

                       250       260
                ....*....|....*....|....*....
gi 70887745 293 IKSVNSSDICPPGVLDDHLEEKSPRLRYL 321
Cdd:COG5238 405 LHTLILDGNLIGAEAQQRLEQLLERIKSV 433
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 75-336 5.18e-05

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 44.78  E-value: 5.18e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887745  75 LYLQNNLIDVLSA----NALRNATQLKWINLNRNKITTEGLE--VDALRAMSNLVHLYMEDNLLSSIPSPLPAKLeqlrL 148
Cdd:COG5238 213 LWLKRNPIGDEGAeilaEALKGNKSLTTLDLSNNQIGDEGVIalAEALKNNTTVETLYLSGNQIGAEGAIALAKA----L 288

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887745 149 SRNKiskippgvfsgmgHLTLLDLQSNKLQDDAVTEV--SLKGLNNLIQINLAKNQLnsmplglpptttqifldGNNIEK 226
Cdd:COG5238 289 QGNT-------------TLTSLDLSVNRIGDEGAIALaeGLQGNKTLHTLNLAYNGI-----------------GAQGAI 338

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887745 227 IPAEYFKGLPKVASLRLNRNKLANGG---IPKNVFNLSSILDLQLSHNQLTEVPVISsglehlhldhnkiksvnssdicp 303
Cdd:COG5238 339 ALAKALQENTTLHSLDLSDNQIGDEGaiaLAKYLEGNTTLRELNLGKNNIGKQGAEA----------------------- 395

                       250       260       270
                ....*....|....*....|....*....|...
gi 70887745 304 pgvLDDHLEEKspRLRYLRLDGNEIQPPIPREL 336
Cdd:COG5238 396 ---LIDALQTN--RLHTLILDGNLIGAEAQQRL 423
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
196-336 9.69e-05

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 44.38  E-value: 9.69e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887745  196 INLAKNQLNSMPLGLPPTTTQIFLDGNNIEKIPAEyfkgLPKVASLRLNRNKLANGGI-PKNVFNLsSILDLQLSH---- 270
Cdd:PRK15387 206 LNVGESGLTTLPDCLPAHITTLVIPDNNLTSLPAL----PPELRTLEVSGNQLTSLPVlPPGLLEL-SIFSNPLTHlpal 280

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887745  271 -----------NQLTEVPVISSGLEHLHLDHNKIKSVNS--SDICPPGVLDDHLEE---KSPRLRYLRLDGNEIQ--PPI 332
Cdd:PRK15387 281 psglcklwifgNQLTSLPVLPPGLQELSVSDNQLASLPAlpSELCKLWAYNNQLTSlptLPSGLQELSVSDNQLAslPTL 360


                 ....
gi 70887745  333 PREL 336
Cdd:PRK15387 361 PSEL 364
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 75-182 1.41e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 43.11  E-value: 1.41e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887745  75 LYLQNNLIDVLS----ANALRNATQLKWINLNRNKITTEGLEV--DALRAMSNLVHLYMEDN--------LLSSIPSPLP 140
Cdd:cd00116 142 LVLGRNRLEGAScealAKALRANRDLKELNLANNGIGDAGIRAlaEGLKANCNLEVLDLNNNgltdegasALAETLASLK 221

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 70887745 141 AkLEQLRLSRNKI-----SKIPPGVFSGMGHLTLLDLQSNKLQDDAV 182
Cdd:cd00116 222 S-LEVLNLGDNNLtdagaAALASALLSPNISLLTLSLSCNDITDDGA 267
LRR_8 pfam13855
Leucine rich repeat;
217-273 1.42e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.43  E-value: 1.42e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 70887745   217 IFLDGNNIEKIPAEYFKGLPKVASLRLNRNKLanGGIPKNVF-NLSSILDLQLSHNQL 273
Cdd:pfam13855   6 LDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLL--TTLSPGAFsGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 101-328 1.08e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 40.42  E-value: 1.08e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887745 101 LNRNKITTEGlEVDALRAMSNLVHLYMEDNLL-----SSIPSPLPAK--LEQLRLSRNKISKIPPGVFSGMGH------L 167
Cdd:cd00116   5 LKGELLKTER-ATELLPKLLCLQVLRLEGNTLgeeaaKALASALRPQpsLKELCLSLNETGRIPRGLQSLLQGltkgcgL 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887745 168 TLLDLQSNKLQDDAVTEV-SLKGLNNLIQINLAKNQLNSMPLGL--------PPTTTQIFLDGNNIEKIP----AEYFKG 234
Cdd:cd00116  84 QELDLSDNALGPDGCGVLeSLLRSSSLQELKLNNNGLGDRGLRLlakglkdlPPALEKLVLGRNRLEGAScealAKALRA 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887745 235 LPKVASLRLNRNKLANGGIPKNVFNLSS-----ILDLQLSH------NQLTEVPVISSGLEHLHLDHNKIKSVNSSDICp 303
Cdd:cd00116 164 NRDLKELNLANNGIGDAGIRALAEGLKAncnleVLDLNNNGltdegaSALAETLASLKSLEVLNLGDNNLTDAGAAALA- 242

                       250       260
                ....*....|....*....|....*
gi 70887745 304 pgvldDHLEEKSPRLRYLRLDGNEI 328
Cdd:cd00116 243 -----SALLSPNISLLTLSLSCNDI 262
LRR_8 pfam13855
Leucine rich repeat;
266-328 3.02e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.58  E-value: 3.02e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 70887745   266 LQLSHNQLTEVPVIS----SGLEHLHLDHNKIKSVNssdicpPGVLDDhleekSPRLRYLRLDGNEI 328
Cdd:pfam13855   6 LDLSNNRLTSLDDGAfkglSNLKVLDLSNNLLTTLS------PGAFSG-----LPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
236-293 4.40e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.19  E-value: 4.40e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 70887745   236 PKVASLRLNRNKLanGGIPKNVF-NLSSILDLQLSHNQLTEVPVIS----SGLEHLHLDHNKI 293
Cdd:pfam13855   1 PNLRSLDLSNNRL--TSLDDGAFkGLSNLKVLDLSNNLLTTLSPGAfsglPSLRYLDLSGNRL 61
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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