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Conserved domains on  [gi|68342038|ref|NP_001020280|]
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hematopoietic progenitor cell antigen CD34 isoform a precursor [Homo sapiens]

Protein Classification

Herpes_BLLF1 and CD34_antigen domain-containing protein( domain architecture ID 10533843)

Herpes_BLLF1 and CD34_antigen domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CD34_antigen pfam06365
CD34/Podocalyxin family; This family consists of several mammalian CD34 antigen proteins. The ...
 190-385 4.39e-90

CD34/Podocalyxin family; This family consists of several mammalian CD34 antigen proteins. The CD34 antigen is a human leukocyte membrane protein expressed specifically by lymphohematopoietic progenitor cells. CD34 is a phosphoprotein. Activation of protein kinase C (PKC) has been found to enhance CD34 phosphorylation. This family contains several eukaryotic podocalyxin proteins. Podocalyxin is a major membrane protein of the glomerular epithelium and is thought to be involved in maintenance of the architecture of the foot processes and filtration slits characteriztic of this unique epithelium by virtue of its high negative charge. Podocalyxin functions as an anti-adhesin that maintains an open filtration pathway between neighbouring foot processes in the glomerular epithelium by charge repulsion.


:

Pssm-ID: 461884  Cd Length: 211  Bit Score: 270.08  E-value: 4.39e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68342038   190 CLEQNKTSSCAEFKKDRGEGLARVLCGEEQADADAGAQVCSLLLAQSEVRPQCLLLVLANRTEIS--SKLQLMKKHQSDL 267
Cdd:pfam06365   1 ILNLNETSDCEDFKKEKGEDLLQVLCRAFSATFNSPQDVCSILLAKSEENDQCLLLTLANETGLPpkAVLELLKDKRRDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68342038   268 KKLGILDFT------EQDVASHQSYSQKTLIALVTSGALLAVLGITGYF--LMNRRSWSPTGERLGEDPYYTENGG-GQG 338
Cdd:pfam06365  81 EELGIQNFTygtecqEEDVQSHQDYSKLTLIALVTSGILLAILLVAGYYgcLHRRRSKSKAGERLGEELQTVENGYhDNP 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 68342038   339 -YSSGPGTSPEAQGKASVNRGAQENGTGQAT---SRNGHSARQHVVADTEL 385
Cdd:pfam06365 161 tLSVAPDTQSEMQEKPSVNGGAQENGTGSWIvplSRNGHSDRQHVEEDTHL 211
 
Name Accession Description Interval E-value
CD34_antigen pfam06365
CD34/Podocalyxin family; This family consists of several mammalian CD34 antigen proteins. The ...
 190-385 4.39e-90

CD34/Podocalyxin family; This family consists of several mammalian CD34 antigen proteins. The CD34 antigen is a human leukocyte membrane protein expressed specifically by lymphohematopoietic progenitor cells. CD34 is a phosphoprotein. Activation of protein kinase C (PKC) has been found to enhance CD34 phosphorylation. This family contains several eukaryotic podocalyxin proteins. Podocalyxin is a major membrane protein of the glomerular epithelium and is thought to be involved in maintenance of the architecture of the foot processes and filtration slits characteriztic of this unique epithelium by virtue of its high negative charge. Podocalyxin functions as an anti-adhesin that maintains an open filtration pathway between neighbouring foot processes in the glomerular epithelium by charge repulsion.


Pssm-ID: 461884  Cd Length: 211  Bit Score: 270.08  E-value: 4.39e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68342038   190 CLEQNKTSSCAEFKKDRGEGLARVLCGEEQADADAGAQVCSLLLAQSEVRPQCLLLVLANRTEIS--SKLQLMKKHQSDL 267
Cdd:pfam06365   1 ILNLNETSDCEDFKKEKGEDLLQVLCRAFSATFNSPQDVCSILLAKSEENDQCLLLTLANETGLPpkAVLELLKDKRRDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68342038   268 KKLGILDFT------EQDVASHQSYSQKTLIALVTSGALLAVLGITGYF--LMNRRSWSPTGERLGEDPYYTENGG-GQG 338
Cdd:pfam06365  81 EELGIQNFTygtecqEEDVQSHQDYSKLTLIALVTSGILLAILLVAGYYgcLHRRRSKSKAGERLGEELQTVENGYhDNP 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 68342038   339 -YSSGPGTSPEAQGKASVNRGAQENGTGQAT---SRNGHSARQHVVADTEL 385
Cdd:pfam06365 161 tLSVAPDTQSEMQEKPSVNGGAQENGTGSWIvplSRNGHSDRQHVEEDTHL 211
 
Name Accession Description Interval E-value
CD34_antigen pfam06365
CD34/Podocalyxin family; This family consists of several mammalian CD34 antigen proteins. The ...
 190-385 4.39e-90

CD34/Podocalyxin family; This family consists of several mammalian CD34 antigen proteins. The CD34 antigen is a human leukocyte membrane protein expressed specifically by lymphohematopoietic progenitor cells. CD34 is a phosphoprotein. Activation of protein kinase C (PKC) has been found to enhance CD34 phosphorylation. This family contains several eukaryotic podocalyxin proteins. Podocalyxin is a major membrane protein of the glomerular epithelium and is thought to be involved in maintenance of the architecture of the foot processes and filtration slits characteriztic of this unique epithelium by virtue of its high negative charge. Podocalyxin functions as an anti-adhesin that maintains an open filtration pathway between neighbouring foot processes in the glomerular epithelium by charge repulsion.


Pssm-ID: 461884  Cd Length: 211  Bit Score: 270.08  E-value: 4.39e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68342038   190 CLEQNKTSSCAEFKKDRGEGLARVLCGEEQADADAGAQVCSLLLAQSEVRPQCLLLVLANRTEIS--SKLQLMKKHQSDL 267
Cdd:pfam06365   1 ILNLNETSDCEDFKKEKGEDLLQVLCRAFSATFNSPQDVCSILLAKSEENDQCLLLTLANETGLPpkAVLELLKDKRRDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68342038   268 KKLGILDFT------EQDVASHQSYSQKTLIALVTSGALLAVLGITGYF--LMNRRSWSPTGERLGEDPYYTENGG-GQG 338
Cdd:pfam06365  81 EELGIQNFTygtecqEEDVQSHQDYSKLTLIALVTSGILLAILLVAGYYgcLHRRRSKSKAGERLGEELQTVENGYhDNP 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 68342038   339 -YSSGPGTSPEAQGKASVNRGAQENGTGQAT---SRNGHSARQHVVADTEL 385
Cdd:pfam06365 161 tLSVAPDTQSEMQEKPSVNGGAQENGTGSWIvplSRNGHSDRQHVEEDTHL 211
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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