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Conserved domains on  [gi|66730473|ref|NP_001019513|]
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dynein axonemal intermediate chain 1 [Rattus norvegicus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 358-616 4.14e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 82.38  E-value: 4.14e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66730473 358 GSYDfmkqsrGMLLLYSMKNPSFPEYMFSSESGIMCLDMHmDHPYLVVVGYYDGNVAIYNLKKPHSQPCFRStsksgkHT 437
Cdd:cd00200  69 GSSD------KTIRLWDLETGECVRTLTGHTSYVSSVAFS-PDGRILSSSSRDKTIKVWDVETGKCLTTLRG------HT 135

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66730473 438 DPVWQVKWQKDDMdhnlnF-FSVSSDGRIVSWTLVKSELVHIdviklkdegstteipegLQLHTvGCGTAFDFHKEiDYL 516
Cdd:cd00200 136 DWVNSVAFSPDGT-----FvASSSQDGTIKLWDLRTGKCVAT-----------------LTGHT-GEVNSVAFSPD-GEK 191

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66730473 517 FLVGTEEGKIyKCSKSYSSQFLDTYDAHNMAVDAVLWNPyHARVFISCSSDWTVKIWDHAIKTPMFIYDL-NAAVGDVAW 595
Cdd:cd00200 192 LLSSSSDGTI-KLWDLSTGKCLGTLRGHENGVNSVAFSP-DGYLLASGSEDGTIRVWDLRTGECVQTLSGhTNSVTSLAW 269

                       250       260
                ....*....|....*....|.
gi 66730473 596 APySSTVFAAVTTDGKAHVFD 616
Cdd:cd00200 270 SP-DGKRLASGSADGTIRIWD 289
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 358-616 4.14e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 82.38  E-value: 4.14e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66730473 358 GSYDfmkqsrGMLLLYSMKNPSFPEYMFSSESGIMCLDMHmDHPYLVVVGYYDGNVAIYNLKKPHSQPCFRStsksgkHT 437
Cdd:cd00200  69 GSSD------KTIRLWDLETGECVRTLTGHTSYVSSVAFS-PDGRILSSSSRDKTIKVWDVETGKCLTTLRG------HT 135

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66730473 438 DPVWQVKWQKDDMdhnlnF-FSVSSDGRIVSWTLVKSELVHIdviklkdegstteipegLQLHTvGCGTAFDFHKEiDYL 516
Cdd:cd00200 136 DWVNSVAFSPDGT-----FvASSSQDGTIKLWDLRTGKCVAT-----------------LTGHT-GEVNSVAFSPD-GEK 191

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66730473 517 FLVGTEEGKIyKCSKSYSSQFLDTYDAHNMAVDAVLWNPyHARVFISCSSDWTVKIWDHAIKTPMFIYDL-NAAVGDVAW 595
Cdd:cd00200 192 LLSSSSDGTI-KLWDLSTGKCLGTLRGHENGVNSVAFSP-DGYLLASGSEDGTIRVWDLRTGECVQTLSGhTNSVTSLAW 269

                       250       260
                ....*....|....*....|.
gi 66730473 596 APySSTVFAAVTTDGKAHVFD 616
Cdd:cd00200 270 SP-DGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
403-618 1.25e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 51.45  E-value: 1.25e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66730473 403 LVVVGYYDGNVAIYNLKKPHSQPCFRstsksgKHTDPVWQVKWQKDdmdhNLNFFSVSSDGRIVSWTLVKSELVHIdvik 482
Cdd:COG2319  92 LLASASADGTVRLWDLATGLLLRTLT------GHTGAVRSVAFSPD----GKTLASGSADGTVRLWDLATGKLLRT---- 157

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66730473 483 lkdegstteipegLQLHTvGCGTAFDFHKEIDYLfLVGTEEG--KIYKCSksySSQFLDTYDAHNMAVDAVLWNPyHARV 560
Cdd:COG2319 158 -------------LTGHS-GAVTSVAFSPDGKLL-ASGSDDGtvRLWDLA---TGKLLRTLTGHTGAVRSVAFSP-DGKL 218

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 66730473 561 FISCSSDWTVKIWDhaIKTPMFIYDLN---AAVGDVAWAPYSSTVfAAVTTDGKAHVFDLA 618
Cdd:COG2319 219 LASGSADGTVRLWD--LATGKLLRTLTghsGSVRSVAFSPDGRLL-ASGSADGTVRLWDLA 276
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 534-574 6.01e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.46  E-value: 6.01e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 66730473    534 SSQFLDTYDAHNMAVDAVLWNPyHARVFISCSSDWTVKIWD 574
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
535-574 8.90e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.02  E-value: 8.90e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 66730473   535 SQFLDTYDAHNMAVDAVLWNPYHaRVFISCSSDWTVKIWD 574
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDG-KLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 358-616 4.14e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 82.38  E-value: 4.14e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66730473 358 GSYDfmkqsrGMLLLYSMKNPSFPEYMFSSESGIMCLDMHmDHPYLVVVGYYDGNVAIYNLKKPHSQPCFRStsksgkHT 437
Cdd:cd00200  69 GSSD------KTIRLWDLETGECVRTLTGHTSYVSSVAFS-PDGRILSSSSRDKTIKVWDVETGKCLTTLRG------HT 135

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66730473 438 DPVWQVKWQKDDMdhnlnF-FSVSSDGRIVSWTLVKSELVHIdviklkdegstteipegLQLHTvGCGTAFDFHKEiDYL 516
Cdd:cd00200 136 DWVNSVAFSPDGT-----FvASSSQDGTIKLWDLRTGKCVAT-----------------LTGHT-GEVNSVAFSPD-GEK 191

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66730473 517 FLVGTEEGKIyKCSKSYSSQFLDTYDAHNMAVDAVLWNPyHARVFISCSSDWTVKIWDHAIKTPMFIYDL-NAAVGDVAW 595
Cdd:cd00200 192 LLSSSSDGTI-KLWDLSTGKCLGTLRGHENGVNSVAFSP-DGYLLASGSEDGTIRVWDLRTGECVQTLSGhTNSVTSLAW 269

                       250       260
                ....*....|....*....|.
gi 66730473 596 APySSTVFAAVTTDGKAHVFD 616
Cdd:cd00200 270 SP-DGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 386-659 9.02e-15

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 75.45  E-value: 9.02e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66730473 386 SSESGIMCLDMHMDHPYLVVvGYYDGNVAIYNLKkpHSQPCFRSTSksgkHTDPVWQVKWqkddMDHNLNFFSVSSDGRI 465
Cdd:cd00200   7 GHTGGVTCVAFSPDGKLLAT-GSGDGTIKVWDLE--TGELLRTLKG----HTGPVRDVAA----SADGTYLASGSSDKTI 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66730473 466 VSWTLVKSELVHIdviklkdegstteipegLQLHTVGCgTAFDFHKEIDYLfLVGTEEGKIyKCSKSYSSQFLDTYDAHN 545
Cdd:cd00200  76 RLWDLETGECVRT-----------------LTGHTSYV-SSVAFSPDGRIL-SSSSRDKTI-KVWDVETGKCLTTLRGHT 135

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66730473 546 MAVDAVLWNPYHARVFiSCSSDWTVKIWDhaIKTPMFIYDLNAAVGDV---AWAPySSTVFAAVTTDGKAHVFDLAVNKY 622
Cdd:cd00200 136 DWVNSVAFSPDGTFVA-SSSQDGTIKLWD--LRTGKCVATLTGHTGEVnsvAFSP-DGEKLLSSSSDGTIKLWDLSTGKC 211

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 66730473 623 EAICNqpvvaKKKNKITHVQFNPIHPIIIVGDDRGHI 659
Cdd:cd00200 212 LGTLR-----GHENGVNSVAFSPDGYLLASGSEDGTI 243
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 496-671 1.34e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 56.96  E-value: 1.34e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66730473 496 LQLHTVGCgTAFDFHKEIDYLfLVGTEEGKIYKCSKSySSQFLDTYDAHNMAVDAVLWNPYHARVFiSCSSDWTVKIWDh 575
Cdd:cd00200   5 LKGHTGGV-TCVAFSPDGKLL-ATGSGDGTIKVWDLE-TGELLRTLKGHTGPVRDVAASADGTYLA-SGSSDKTIRLWD- 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66730473 576 aIKTPMFIYDL---NAAVGDVAWAPySSTVFAAVTTDGKAHVFDLAVNKYEAICNQpvvakKKNKITHVQFNPIHPIIIV 652
Cdd:cd00200  80 -LETGECVRTLtghTSYVSSVAFSP-DGRILSSSSRDKTIKVWDVETGKCLTTLRG-----HTDWVNSVAFSPDGTFVAS 152

                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 66730473 653 GDD------------------RGH---ITCLKLSPNLRKM 671
Cdd:cd00200 153 SSQdgtiklwdlrtgkcvatlTGHtgeVNSVAFSPDGEKL 192
WD40 COG2319
WD40 repeat [General function prediction only];
403-618 1.25e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 51.45  E-value: 1.25e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66730473 403 LVVVGYYDGNVAIYNLKKPHSQPCFRstsksgKHTDPVWQVKWQKDdmdhNLNFFSVSSDGRIVSWTLVKSELVHIdvik 482
Cdd:COG2319  92 LLASASADGTVRLWDLATGLLLRTLT------GHTGAVRSVAFSPD----GKTLASGSADGTVRLWDLATGKLLRT---- 157

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66730473 483 lkdegstteipegLQLHTvGCGTAFDFHKEIDYLfLVGTEEG--KIYKCSksySSQFLDTYDAHNMAVDAVLWNPyHARV 560
Cdd:COG2319 158 -------------LTGHS-GAVTSVAFSPDGKLL-ASGSDDGtvRLWDLA---TGKLLRTLTGHTGAVRSVAFSP-DGKL 218

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 66730473 561 FISCSSDWTVKIWDhaIKTPMFIYDLN---AAVGDVAWAPYSSTVfAAVTTDGKAHVFDLA 618
Cdd:COG2319 219 LASGSADGTVRLWD--LATGKLLRTLTghsGSVRSVAFSPDGRLL-ASGSADGTVRLWDLA 276
WD40 COG2319
WD40 repeat [General function prediction only];
403-618 2.73e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 50.29  E-value: 2.73e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66730473 403 LVVVGYYDGNVAIYNLKkphSQPCFRSTSKsgkHTDPVWQVKWqkdDMDHNLnFFSVSSDGRIVSWTLVKSELVHIdvik 482
Cdd:COG2319 176 LLASGSDDGTVRLWDLA---TGKLLRTLTG---HTGAVRSVAF---SPDGKL-LASGSADGTVRLWDLATGKLLRT---- 241

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66730473 483 lkdegstteipegLQLHTvGCGTAFDFHKeiDYLFLV-GTEEGKIYKCSKSySSQFLDTYDAHNMAVDAVLWNPyHARVF 561
Cdd:COG2319 242 -------------LTGHS-GSVRSVAFSP--DGRLLAsGSADGTVRLWDLA-TGELLRTLTGHSGGVNSVAFSP-DGKLL 303

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 66730473 562 ISCSSDWTVKIWDHAIKTPMFIYD-LNAAVGDVAWAPYSSTVfAAVTTDGKAHVFDLA 618
Cdd:COG2319 304 ASGSDDGTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKTL-ASGSDDGTVRLWDLA 360
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 534-574 6.01e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.46  E-value: 6.01e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 66730473    534 SSQFLDTYDAHNMAVDAVLWNPyHARVFISCSSDWTVKIWD 574
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 COG2319
WD40 repeat [General function prediction only];
534-659 6.79e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 45.67  E-value: 6.79e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66730473 534 SSQFLDTYDAHNMAVDAVLWNPyHARVFISCSSDWTVKIWDhaIKTPMFIYDLN---AAVGDVAWAPySSTVFAAVTTDG 610
Cdd:COG2319 109 TGLLLRTLTGHTGAVRSVAFSP-DGKTLASGSADGTVRLWD--LATGKLLRTLTghsGAVTSVAFSP-DGKLLASGSDDG 184

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 66730473 611 KAHVFDLAVNKYEAicnqpVVAKKKNKITHVQFNPIHPIIIVGDDRGHI 659
Cdd:COG2319 185 TVRLWDLATGKLLR-----TLTGHTGAVRSVAFSPDGKLLASGSADGTV 228
WD40 pfam00400
WD domain, G-beta repeat;
535-574 8.90e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.02  E-value: 8.90e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 66730473   535 SQFLDTYDAHNMAVDAVLWNPYHaRVFISCSSDWTVKIWD 574
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDG-KLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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