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Conserved domains on  [gi|66392221|ref|NP_001018164|]
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serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C [Danio rerio]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
56-343 1.70e-51

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 183.23  E-value: 1.70e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   56 IMDLLISAGANVNAKDHVWLTPLHRAAASRNERAVGLLLRKGADVTARDKYWQTPLHIAAANRATRCVETLLPHVSSLNM 135
Cdd:COG0666    3 LLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221  136 ADRTGRAPLHHAAQSGYQEMVKLLLNKGANLSASDKKDRQPIHWAAYLGHLEVVKLLVSQGSDKSCKDKRGYTPLHAAAA 215
Cdd:COG0666   83 KDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAA 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221  216 SGHVDVVKYLLRNGAEIDEPNAFGNTALHVACYTGQEAVANELVNRGANVNQPNHRGYTPLHLAAVSTNGALcLELLVNN 295
Cdd:COG0666  163 NGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEI-VKLLLEA 241

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 66392221  296 GADVNMQSKEGKSPLHMAAIHGRFTRSQILIQNGGEIDCVDRYGNTPL 343
Cdd:COG0666  242 GADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
289-602 1.62e-36

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 140.09  E-value: 1.62e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221  289 LELLVNNGADVNMQSKEGKSPLHMAAIHGRFTRSQILIQNGGEIDCVDRYGNTPLHVAAKYGHELLISTLMTNGADTARQ 368
Cdd:COG0666    4 LLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAK 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221  369 GIHGMFPLHLAVLYGSSDCCRKLLSsgqlysivlsmskehvlsAGFDINTPDNFGRTCLHAAASGGNIECLNLLLSSGAD 448
Cdd:COG0666   84 DDGGNTLLHAAARNGDLEIVKLLLE------------------AGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGAD 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221  449 MNKKDKFGRTPLHYAAANGRYQCVVVLVGAGAEVNERDRSGCTPLHYsaastafcrtdrphASTHQNQEdgekesflCVE 528
Cdd:COG0666  146 VNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHL--------------AAENGHLE--------IVK 203

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 66392221  529 HLLDNGADPCLCNTKGYSAVHYAAAHGNKQNLELLLEMcfNTLGDKESNGSISPLHLAVESGHWECVTVLIESG 602
Cdd:COG0666  204 LLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEA--GADLNAKDKDGLTALLLAAAAGAALIVKLLLLAL 275
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
530-771 1.89e-33

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 130.84  E-value: 1.89e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221  530 LLDNGADPCLCNTKGYSAVHYAAAHGNKQNLELLLEMCFNTlgDKESNGSISPLHLAVESGHWECVTVLIESGVCVDVCD 609
Cdd:COG0666   40 LLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADI--NAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARD 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221  610 PVGRSVLYLASQRGHSRCVELLLSQSAScLLAEHRSKWGPLHVAAANGHSECLRMLLcsEGGADlVNVTDAEGQTPLMLA 689
Cdd:COG0666  118 KDGETPLHLAAYNGNLEIVKLLLEAGAD-VNAQDNDGNTPLHLAAANGNLEIVKLLL--EAGAD-VNARDNDGETPLHLA 193

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221  690 VLGGHTDCVHLLLERGACPDMKDRRGRTALHRGAVMGREDCLTALLSHNVSVLSRDFQGRSALHLAASCGHADILSNLLS 769
Cdd:COG0666  194 AENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLL 273


                 ..
gi 66392221  770 AA 771
Cdd:COG0666  274 AL 275
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
672-951 1.14e-29

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 120.06  E-value: 1.14e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221  672 ADLVNVTDAEGQTPLMLAVLGGHTDCVHLLLERGACPDMKDRRGRTALHRGAVMGREDCLTALLSHNVSVLSRDFQGRSA 751
Cdd:COG0666   11 LLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTL 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221  752 LHLAASCGHADILSNLLSAADhsqpqDP-LTDRHGYTPAHWAAYHGHEDCLEVLLELK-PCSIQEGNPFTPLHCALINGH 829
Cdd:COG0666   91 LHAAARNGDLEIVKLLLEAGA-----DVnARDKDGETPLHLAAYNGNLEIVKLLLEAGaDVNAQDNDGNTPLHLAAANGN 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221  830 SGSAELLLESsvcNSLVNIRDAKGRTPLHAAAVAEDVAGLQLVLRQGADIDAVDHSGRSALMVAADYGQSGAVALLLhRA 909
Cdd:COG0666  166 LEIVKLLLEA---GADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLL-EA 241

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 66392221  910 KADLSLLDVNKNTALHLACSKAHEMCAMLILKEIHNPILINA 951
Cdd:COG0666  242 GADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALL 283
Ank_5 pfam13857
Ankyrin repeats (many copies);
944-992 1.89e-05

Ankyrin repeats (many copies);


:

Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 43.10  E-value: 1.89e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 66392221    944 HNPILINATNSMLQMPLHIAARNGLATVVQALLNRGATVLAVDEEGHTP 992
Cdd:pfam13857    4 HGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTA 52
Ank_4 pfam13637
Ankyrin repeats (many copies);
10-61 7.13e-03

Ankyrin repeats (many copies);


:

Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 35.71  E-value: 7.13e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 66392221     10 PPLVQAIFNRNADEVKLFLHKKDEVNALDQERRTPLHAAAWLGDVHIMDLLI 61
Cdd:pfam13637    3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
56-343 1.70e-51

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 183.23  E-value: 1.70e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   56 IMDLLISAGANVNAKDHVWLTPLHRAAASRNERAVGLLLRKGADVTARDKYWQTPLHIAAANRATRCVETLLPHVSSLNM 135
Cdd:COG0666    3 LLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221  136 ADRTGRAPLHHAAQSGYQEMVKLLLNKGANLSASDKKDRQPIHWAAYLGHLEVVKLLVSQGSDKSCKDKRGYTPLHAAAA 215
Cdd:COG0666   83 KDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAA 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221  216 SGHVDVVKYLLRNGAEIDEPNAFGNTALHVACYTGQEAVANELVNRGANVNQPNHRGYTPLHLAAVSTNGALcLELLVNN 295
Cdd:COG0666  163 NGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEI-VKLLLEA 241

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 66392221  296 GADVNMQSKEGKSPLHMAAIHGRFTRSQILIQNGGEIDCVDRYGNTPL 343
Cdd:COG0666  242 GADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
PHA03095 PHA03095
ankyrin-like protein; Provisional
 53-317 7.63e-37

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 145.55  E-value: 7.63e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221    53 DVHIMDLLISAGANVNAKDHVWLTPLHRAAASRNE---RAVGLLLRKGADVTARDKYWQTPLHIAAANRAT-RCVETLLP 128
Cdd:PHA03095   26 TVEEVRRLLAAGADVNFRGEYGKTPLHLYLHYSSEkvkDIVRLLLEAGADVNAPERCGFTPLHLYLYNATTlDVIKLLIK 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   129 HVSSLNMADRTGRAPLH-HAA-QSGYQEMVKLLLNKGANLSASDKKDRQPIHwaAYLGH----LEVVKLLVSQGSDKSCK 202
Cdd:PHA03095  106 AGADVNAKDKVGRTPLHvYLSgFNINPKVIRLLLRKGADVNALDLYGMTPLA--VLLKSrnanVELLRLLIDAGADVYAV 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   203 DKRGYTPLHAAAASGHVD--VVKYLLRNGAEIDEPNAFGNTALHV-ACYTGQEA--VANeLVNRGANVNQPNHRGYTPLH 277
Cdd:PHA03095  184 DDRFRSLLHHHLQSFKPRarIVRELIRAGCDPAATDMLGNTPLHSmATGSSCKRslVLP-LLIAGISINARNRYGQTPLH 262

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 66392221   278 LAAVSTNGALCLELLvNNGADVNMQSKEGKSPLHMAAIHG 317
Cdd:PHA03095  263 YAAVFNNPRACRRLI-ALGADINAVSSDGNTPLSLMVRNN 301
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
289-602 1.62e-36

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 140.09  E-value: 1.62e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221  289 LELLVNNGADVNMQSKEGKSPLHMAAIHGRFTRSQILIQNGGEIDCVDRYGNTPLHVAAKYGHELLISTLMTNGADTARQ 368
Cdd:COG0666    4 LLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAK 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221  369 GIHGMFPLHLAVLYGSSDCCRKLLSsgqlysivlsmskehvlsAGFDINTPDNFGRTCLHAAASGGNIECLNLLLSSGAD 448
Cdd:COG0666   84 DDGGNTLLHAAARNGDLEIVKLLLE------------------AGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGAD 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221  449 MNKKDKFGRTPLHYAAANGRYQCVVVLVGAGAEVNERDRSGCTPLHYsaastafcrtdrphASTHQNQEdgekesflCVE 528
Cdd:COG0666  146 VNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHL--------------AAENGHLE--------IVK 203

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 66392221  529 HLLDNGADPCLCNTKGYSAVHYAAAHGNKQNLELLLEMcfNTLGDKESNGSISPLHLAVESGHWECVTVLIESG 602
Cdd:COG0666  204 LLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEA--GADLNAKDKDGLTALLLAAAAGAALIVKLLLLAL 275
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
530-771 1.89e-33

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 130.84  E-value: 1.89e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221  530 LLDNGADPCLCNTKGYSAVHYAAAHGNKQNLELLLEMCFNTlgDKESNGSISPLHLAVESGHWECVTVLIESGVCVDVCD 609
Cdd:COG0666   40 LLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADI--NAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARD 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221  610 PVGRSVLYLASQRGHSRCVELLLSQSAScLLAEHRSKWGPLHVAAANGHSECLRMLLcsEGGADlVNVTDAEGQTPLMLA 689
Cdd:COG0666  118 KDGETPLHLAAYNGNLEIVKLLLEAGAD-VNAQDNDGNTPLHLAAANGNLEIVKLLL--EAGAD-VNARDNDGETPLHLA 193

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221  690 VLGGHTDCVHLLLERGACPDMKDRRGRTALHRGAVMGREDCLTALLSHNVSVLSRDFQGRSALHLAASCGHADILSNLLS 769
Cdd:COG0666  194 AENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLL 273


                 ..
gi 66392221  770 AA 771
Cdd:COG0666  274 AL 275
PHA03095 PHA03095
ankyrin-like protein; Provisional
 219-555 3.72e-30

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 125.52  E-value: 3.72e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   219 VDVVKYLLRNGAEIDEPNAFGNTALHVACYTGQEAVA---NELVNRGANVNQPNHRGYTPLHLAAVSTNGALCLELLVNN 295
Cdd:PHA03095   27 VEEVRRLLAAGADVNFRGEYGKTPLHLYLHYSSEKVKdivRLLLEAGADVNAPERCGFTPLHLYLYNATTLDVIKLLIKA 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   296 GADVNMQSKEGKSPLHmAAIHGRFTRS---QILIQNGGEIDCVDRYGNTPLHVaakygheLLISTLMTngADTARqgihg 372
Cdd:PHA03095  107 GADVNAKDKVGRTPLH-VYLSGFNINPkviRLLLRKGADVNALDLYGMTPLAV-------LLKSRNAN--VELLR----- 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   373 MFPLHLAVLYGSSDCCRKLLSSGQLY-----SIVlsmskEHVLSAGFDINTPDNFGRTCLHAAASGGNIECLNL--LLSS 445
Cdd:PHA03095  172 LLIDAGADVYAVDDRFRSLLHHHLQSfkpraRIV-----RELIRAGCDPAATDMLGNTPLHSMATGSSCKRSLVlpLLIA 246

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   446 GADMNKKDKFGRTPLHYAAANGRYQCVVVLVGAGAEVNERDRSGCTPL------HYSAASTAFCRTdRPHASTHQNQedg 519
Cdd:PHA03095  247 GISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLslmvrnNNGRAVRAALAK-NPSAETVAAT--- 322

                         330       340       350
                  ....*....|....*....|....*....|....*.
gi 66392221   520 ekesflcVEHLLDNGADPCLCNTKgySAVHYAAAHG 555
Cdd:PHA03095  323 -------LNTASVAGGDIPSDATR--LCVAKVVLRG 349
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
672-951 1.14e-29

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 120.06  E-value: 1.14e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221  672 ADLVNVTDAEGQTPLMLAVLGGHTDCVHLLLERGACPDMKDRRGRTALHRGAVMGREDCLTALLSHNVSVLSRDFQGRSA 751
Cdd:COG0666   11 LLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTL 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221  752 LHLAASCGHADILSNLLSAADhsqpqDP-LTDRHGYTPAHWAAYHGHEDCLEVLLELK-PCSIQEGNPFTPLHCALINGH 829
Cdd:COG0666   91 LHAAARNGDLEIVKLLLEAGA-----DVnARDKDGETPLHLAAYNGNLEIVKLLLEAGaDVNAQDNDGNTPLHLAAANGN 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221  830 SGSAELLLESsvcNSLVNIRDAKGRTPLHAAAVAEDVAGLQLVLRQGADIDAVDHSGRSALMVAADYGQSGAVALLLhRA 909
Cdd:COG0666  166 LEIVKLLLEA---GADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLL-EA 241

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 66392221  910 KADLSLLDVNKNTALHLACSKAHEMCAMLILKEIHNPILINA 951
Cdd:COG0666  242 GADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALL 283
Ank_2 pfam12796
Ankyrin repeats (3 copies);
177-269 7.69e-22

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 90.95  E-value: 7.69e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221    177 IHWAAYLGHLEVVKLLVSQGSDKSCKDKRGYTPLHAAAASGHVDVVKYLLRNgAEIDEPNaFGNTALHVACYTGQEAVAN 256
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVK 78

                           90
                   ....*....|...
gi 66392221    257 ELVNRGANVNQPN 269
Cdd:pfam12796   79 LLLEKGADINVKD 91
Ank_2 pfam12796
Ankyrin repeats (3 copies);
650-745 8.85e-18

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 79.39  E-value: 8.85e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221    650 LHVAAANGHSECLRMLLcsEGGADlVNVTDAEGQTPLMLAVLGGHTDCVHLLLERgACPDMKDRrGRTALHRGAVMGRED 729
Cdd:pfam12796    1 LHLAAKNGNLELVKLLL--ENGAD-ANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDN-GRTALHYAARSGHLE 75

                           90
                   ....*....|....*.
gi 66392221    730 CLTALLSHNVSVLSRD 745
Cdd:pfam12796   76 IVKLLLEKGADINVKD 91
Ank_2 pfam12796
Ankyrin repeats (3 copies);
376-486 2.90e-17

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 77.85  E-value: 2.90e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221    376 LHLAVLYGSSDCCRKLLSSGqlysivlsmskehvlsagFDINTPDNFGRTCLHAAASGGNIECLNLLLSSgADMNKKDKf 455
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENG------------------ADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDN- 60

                           90       100       110
                   ....*....|....*....|....*....|.
gi 66392221    456 GRTPLHYAAANGRYQCVVVLVGAGAEVNERD 486
Cdd:pfam12796   61 GRTALHYAARSGHLEIVKLLLEKGADINVKD 91
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 516-907 2.95e-16

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 83.57  E-value: 2.95e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   516 QEDGEKESFLCVEHLLDNGADPCLCNTKGYSAVHYAAAHGNKQNLELLL----EMCFNTLGDkesngsISPLHLAVESGH 591
Cdd:PHA02876  150 KERIQQDELLIAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLsygaDVNIIALDD------LSVLECAVDSKN 223

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   592 WECVTVLIESGVCVDVCDpvgrsVLYLASQRGHSRCVELLLSQSASCLLAEHRSKWGPLHVAA-ANGHSECLRMLLcsEG 670
Cdd:PHA02876  224 IDTIKAIIDNRSNINKND-----LSLLKAIRNEDLETSLLLYDAGFSVNSIDDCKNTPLHHASqAPSLSRLVPKLL--ER 296

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   671 GADlVNVTDAEGQTPLMLAVLGGH-TDCVHLLLERGACPDMKDRRGRTALHRGAVMGR-EDCLTALLSHNVSVLSRDFQG 748
Cdd:PHA02876  297 GAD-VNAKNIKGETPLYLMAKNGYdTENIRTLIMLGADVNAADRLYITPLHQASTLDRnKDIVITLLELGANVNARDYCD 375

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   749 RSALHLAASCGHADILSNLLsaaDHSQPQDPLTDRHGyTPAHWAAYHghedclevllelkpcsiqeGNPFTPLHCALING 828
Cdd:PHA02876  376 KTPIHYAAVRNNVVIINTLL---DYGADIEALSQKIG-TALHFALCG-------------------TNPYMSVKTLIDRG 432

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   829 HSgsaelllessvcnslVNIRDAKGRTPLHAAA---VAEDVagLQLVLRQGADIDAVDHSGRSALMVAADYgqSGAVALL 905
Cdd:PHA02876  433 AN---------------VNSKNKDLSTPLHYACkknCKLDV--IEMLLDNGADVNAINIQNQYPLLIALEY--HGIVNIL 493


                  ..
gi 66392221   906 LH 907
Cdd:PHA02876  494 LH 495
PHA03095 PHA03095
ankyrin-like protein; Provisional
 662-1010 3.65e-15

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 79.30  E-value: 3.65e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   662 LRMLLcsEGGADlVNVTDAEGQTPLMLAVLGGHTDC---VHLLLERGACPDMKDRRGRTALHRGAVMG-REDCLTALLSH 737
Cdd:PHA03095   30 VRRLL--AAGAD-VNFRGEYGKTPLHLYLHYSSEKVkdiVRLLLEAGADVNAPERCGFTPLHLYLYNAtTLDVIKLLIKA 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   738 NVSVLSRDFQGRSALH--LAASCGHADILSNLLSA-ADhsqPQDplTDRHGYTPAHwaAYHGHEDC-LEVL--LELKPCS 811
Cdd:PHA03095  107 GADVNAKDKVGRTPLHvyLSGFNINPKVIRLLLRKgAD---VNA--LDLYGMTPLA--VLLKSRNAnVELLrlLIDAGAD 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   812 I--QEGNPFTPLHCALINGHSgSAELLLESSVCNSLVNIRDAKGRTPLHAAAVAEDVAGLQLV--LRQGADIDAVDHSGR 887
Cdd:PHA03095  180 VyaVDDRFRSLLHHHLQSFKP-RARIVRELIRAGCDPAATDMLGNTPLHSMATGSSCKRSLVLplLIAGISINARNRYGQ 258

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   888 SALMVAADYGQSGAVALLLhRAKADLSLLDVNKNTALHLACSKAHEMCAMLILKEIHNPILINATnsmlqmpLHIAARNG 967
Cdd:PHA03095  259 TPLHYAAVFNNPRACRRLI-ALGADINAVSSDGNTPLSLMVRNNNGRAVRAALAKNPSAETVAAT-------LNTASVAG 330

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 66392221   968 LATVVQALLNRGATVLAVDEEGHTPALACASNKA-VADCLALIL 1010
Cdd:PHA03095  331 GDIPSDATRLCVAKVVLRGAFSLLPEPIRAYHADfIRECEAEIA 374
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 201-445 7.41e-15

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 78.90  E-value: 7.41e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221  201 CKDKRGY-TPLHAAAASGHVDVVKYLLR-NGAEIDEPNAFGNTALHVACYTGQEAVANELVNRGAN-VNQPN----HRGY 273
Cdd:cd22192   11 LQQKRISeSPLLLAAKENDVQAIKKLLKcPSCDLFQRGALGETALHVAALYDNLEAAVVLMEAAPElVNEPMtsdlYQGE 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221  274 TPLHLAAVSTNGALcLELLVNNGADVNMQSKEGKSplhmaaihgrFTRSQiliqnggeiDCVDRYGNTPLHVAAKYGHEL 353
Cdd:cd22192   91 TALHIAVVNQNLNL-VRELIARGADVVSPRATGTF----------FRPGP---------KNLIYYGEHPLSFAACVGNEE 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221  354 LISTLMTNGADTARQGIHGMFPLHLAVLYGSSDccrkllSSGQLYSIVLSMSKE---HVLSagfdiNTPDNFGRTCLHAA 430
Cdd:cd22192  151 IVRLLIEHGADIRAQDSLGNTVLHILVLQPNKT------FACQMYDLILSYDKEddlQPLD-----LVPNNQGLTPFKLA 219

                        250
                 ....*....|....*
gi 66392221  431 ASGGNIECLNLLLSS 445
Cdd:cd22192  220 AKEGNIVMFQHLVQK 234
Ank_2 pfam12796
Ankyrin repeats (3 copies);
790-883 3.11e-12

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 63.60  E-value: 3.11e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221    790 HWAAYHGHEDCLEVLLELKP-CSIQEGNPFTPLHCALINGHSGSAELLLESSVCNSlvnirDAKGRTPLHAAAVAEDVAG 868
Cdd:pfam12796    2 HLAAKNGNLELVKLLLENGAdANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNL-----KDNGRTALHYAARSGHLEI 76

                           90
                   ....*....|....*
gi 66392221    869 LQLVLRQGADIDAVD 883
Cdd:pfam12796   77 VKLLLEKGADINVKD 91
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 274-461 1.06e-09

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 62.34  E-value: 1.06e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221  274 TPLHLAAvSTNGALCLE-LLVNNGADVNMQSKEGKSPLHMAAIHGRFTRSQILIQNGGEIDCV----DRY-GNTPLHVAA 347
Cdd:cd22192   19 SPLLLAA-KENDVQAIKkLLKCPSCDLFQRGALGETALHVAALYDNLEAAVVLMEAAPELVNEpmtsDLYqGETALHIAV 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221  348 KYGHELLISTLMTNGADTA---------RQGIHGMFplhlavLYGssdccrkllssgqlysivlsmskEHVLSagfdint 418
Cdd:cd22192   98 VNQNLNLVRELIARGADVVspratgtffRPGPKNLI------YYG-----------------------EHPLS------- 141

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 66392221  419 pdnFgrtclhaAASGGNIECLNLLLSSGADMNKKDKFGRTPLH 461
Cdd:cd22192  142 ---F-------AACVGNEEIVRLLIEHGADIRAQDSLGNTVLH 174
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 605-826 1.32e-09

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 62.41  E-value: 1.32e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221    605 VDVCDPVGRSVLYLASQRG-HSRCVELLLSQSasCLLAEHRSKwgpLHVAAANGH---SECLRMLLCSEGGAD---LVNV 677
Cdd:TIGR00870   45 INCPDRLGRSALFVAAIENeNLELTELLLNLS--CRGAVGDTL---LHAISLEYVdavEAILLHLLAAFRKSGpleLAND 119

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221    678 TDA----EGQTPLMLAVLGGHTDCVHLLLERGA-------CPDMKDRRGRTALHRG-------AVMGREDCLTALLSHNV 739
Cdd:TIGR00870  120 QYTseftPGITALHLAAHRQNYEIVKLLLERGAsvparacGDFFVKSQGVDSFYHGesplnaaACLGSPSIVALLSEDPA 199

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221    740 SVLSRDFQGRSALHLAA------------SCGHADILSNLLSAADHSQPQDPLTDRHGYTPAHWAAYHGHEDCLEVLLEL 807
Cdd:TIGR00870  200 DILTADSLGNTLLHLLVmenefkaeyeelSCQMYNFALSLLDKLRDSKELEVILNHQGLTPLKLAAKEGRIVLFRLKLAI 279

                          250       260
                   ....*....|....*....|
gi 66392221    808 KPCSIQ-EGNPFTPLHCALI 826
Cdd:TIGR00870  280 KYKQKKfVAWPNGQQLLSLY 299
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 66-284 3.88e-09

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 60.87  E-value: 3.88e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221     66 NVNAKDHVWLTPLHRAAA-SRNERAVGLLLRKGADVTARDkywqTPLHiAAANRATRCVETLLPHV-------SSLNMA- 136
Cdd:TIGR00870   44 NINCPDRLGRSALFVAAIeNENLELTELLLNLSCRGAVGD----TLLH-AISLEYVDAVEAILLHLlaafrksGPLELAn 118

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221    137 DRT------GRAPLHHAAQSGYQEMVKLLLNKGANLSA---------SDKKD-----RQPIHWAAYLGHLEVVKLLVSQG 196
Cdd:TIGR00870  119 DQYtseftpGITALHLAAHRQNYEIVKLLLERGASVPAracgdffvkSQGVDsfyhgESPLNAAACLGSPSIVALLSEDP 198

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221    197 SDKSCKDKRGYTPLHAAAasghvdvvkyllrngaeIDEPNAFGNTALHVACYtgqeavaNELVNRGANVNQ-------PN 269
Cdd:TIGR00870  199 ADILTADSLGNTLLHLLV-----------------MENEFKAEYEELSCQMY-------NFALSLLDKLRDskeleviLN 254

                          250
                   ....*....|....*
gi 66392221    270 HRGYTPLHLAAVSTN 284
Cdd:TIGR00870  255 HQGLTPLKLAAKEGR 269
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 581-720 2.60e-07

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 54.63  E-value: 2.60e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221  581 SPLHLAVESGHWECVTVLIESGVCvDVCD--PVGRSVLYLASQRGH-------SRCVELLLSQSASCLLAEHRSkwgPLH 651
Cdd:cd22192   19 SPLLLAAKENDVQAIKKLLKCPSC-DLFQrgALGETALHVAALYDNleaavvlMEAAPELVNEPMTSDLYQGET---ALH 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221  652 VAAANGHSECLRMLLcsEGGADLVN--VTDA-----------EGQTPLMLAVLGGHTDCVHLLLERGACPDMKDRRGRTA 718
Cdd:cd22192   95 IAVVNQNLNLVRELI--ARGADVVSprATGTffrpgpknliyYGEHPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTV 172


                 ..
gi 66392221  719 LH 720
Cdd:cd22192  173 LH 174
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 787-978 3.06e-07

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 54.63  E-value: 3.06e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221  787 TPAHWAAYHGHEDCLEVLLELKPCSIQEGNPF--TPLHCALINGHSGSAELLLESSvcNSLVNIRDA----KGRTPLHAA 860
Cdd:cd22192   19 SPLLLAAKENDVQAIKKLLKCPSCDLFQRGALgeTALHVAALYDNLEAAVVLMEAA--PELVNEPMTsdlyQGETALHIA 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221  861 AVAEDVAGLQLVLRQGADI--------------DAVDHSGRSALMVAADYGQSGAVALLLHRAkADLSLLDVNKNTALHL 926
Cdd:cd22192   97 VVNQNLNLVRELIARGADVvspratgtffrpgpKNLIYYGEHPLSFAACVGNEEIVRLLIEHG-ADIRAQDSLGNTVLHI 175

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 66392221  927 ACSKAHE--MCAM--LIL---KEIHNPILINATNSMLQMPLHIAARNGLATVVQALLNR 978
Cdd:cd22192  176 LVLQPNKtfACQMydLILsydKEDDLQPLDLVPNNQGLTPFKLAAKEGNIVMFQHLVQK 234
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 332-568 1.71e-06

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 52.01  E-value: 1.71e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221    332 IDCVDRYGNTPLHVAAKYG-HELLISTLMTNGadtaRQGIHGMFPLHLAVLyGSSDCCRKLLSSgQLYSIVLSMSKEHVL 410
Cdd:TIGR00870   45 INCPDRLGRSALFVAAIENeNLELTELLLNLS----CRGAVGDTLLHAISL-EYVDAVEAILLH-LLAAFRKSGPLELAN 118

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221    411 SAGFDINTPDnfgRTCLHAAASGGNIECLNLLLSSGADMNKKDK--------------FGRTPLHYAAANGRYQCVVVLV 476
Cdd:TIGR00870  119 DQYTSEFTPG---ITALHLAAHRQNYEIVKLLLERGASVPARACgdffvksqgvdsfyHGESPLNAAACLGSPSIVALLS 195

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221    477 GAGAEVNERDRSGCTPLHYSAASTAFcrtdrphasthqnQEDGEKESFLCVEHLLDNGADPC-------LCNTKGYSAVH 549
Cdd:TIGR00870  196 EDPADILTADSLGNTLLHLLVMENEF-------------KAEYEELSCQMYNFALSLLDKLRdskelevILNHQGLTPLK 262

                          250
                   ....*....|....*....
gi 66392221    550 YAAAHGNKQNLELLLEMCF 568
Cdd:TIGR00870  263 LAAKEGRIVLFRLKLAIKY 281
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 205-234 9.55e-06

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 43.35  E-value: 9.55e-06
                            10        20        30
                    ....*....|....*....|....*....|
gi 66392221     205 RGYTPLHAAAASGHVDVVKYLLRNGAEIDE 234
Cdd:smart00248    1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
Ank_5 pfam13857
Ankyrin repeats (many copies);
944-992 1.89e-05

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 43.10  E-value: 1.89e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 66392221    944 HNPILINATNSMLQMPLHIAARNGLATVVQALLNRGATVLAVDEEGHTP 992
Cdd:pfam13857    4 HGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTA 52
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 423-451 7.72e-05

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 40.65  E-value: 7.72e-05
                            10        20
                    ....*....|....*....|....*....
gi 66392221     423 GRTCLHAAASGGNIECLNLLLSSGADMNK 451
Cdd:smart00248    2 GRTPLHLAAENGNLEVVKLLLDKGADINA 30
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 878-982 1.10e-03

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 43.15  E-value: 1.10e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221    878 DIDAVDHSGRSALMVAADYGQSGAVA--LLLHRAKADLSlldvnkNTALHLACSKAHEMCAMLIL------KEIHNPILI 949
Cdd:TIGR00870   44 NINCPDRLGRSALFVAAIENENLELTelLLNLSCRGAVG------DTLLHAISLEYVDAVEAILLhllaafRKSGPLELA 117

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 66392221    950 NA----TNSMLQMPLHIAARNGLATVVQALLNRGATV 982
Cdd:TIGR00870  118 NDqytsEFTPGITALHLAAHRQNYEIVKLLLERGASV 154
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 681-710 2.57e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.41  E-value: 2.57e-03
                            10        20        30
                    ....*....|....*....|....*....|
gi 66392221     681 EGQTPLMLAVLGGHTDCVHLLLERGACPDM 710
Cdd:smart00248    1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 957-992 4.52e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 41.04  E-value: 4.52e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 66392221   957 QMPLHIAARNGLATVVQALLNRGATVLAVDEEGHTP 992
Cdd:PTZ00322  116 RTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTP 151
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 784-809 6.62e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 35.26  E-value: 6.62e-03
                            10        20
                    ....*....|....*....|....*.
gi 66392221     784 HGYTPAHWAAYHGHEDCLEVLLELKP 809
Cdd:smart00248    1 DGRTPLHLAAENGNLEVVKLLLDKGA 26
Ank_4 pfam13637
Ankyrin repeats (many copies);
10-61 7.13e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 35.71  E-value: 7.13e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 66392221     10 PPLVQAIFNRNADEVKLFLHKKDEVNALDQERRTPLHAAAWLGDVHIMDLLI 61
Cdd:pfam13637    3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
56-343 1.70e-51

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 183.23  E-value: 1.70e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   56 IMDLLISAGANVNAKDHVWLTPLHRAAASRNERAVGLLLRKGADVTARDKYWQTPLHIAAANRATRCVETLLPHVSSLNM 135
Cdd:COG0666    3 LLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221  136 ADRTGRAPLHHAAQSGYQEMVKLLLNKGANLSASDKKDRQPIHWAAYLGHLEVVKLLVSQGSDKSCKDKRGYTPLHAAAA 215
Cdd:COG0666   83 KDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAA 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221  216 SGHVDVVKYLLRNGAEIDEPNAFGNTALHVACYTGQEAVANELVNRGANVNQPNHRGYTPLHLAAVSTNGALcLELLVNN 295
Cdd:COG0666  163 NGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEI-VKLLLEA 241

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 66392221  296 GADVNMQSKEGKSPLHMAAIHGRFTRSQILIQNGGEIDCVDRYGNTPL 343
Cdd:COG0666  242 GADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
21-300 4.74e-49

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 176.30  E-value: 4.74e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   21 ADEVKLFLHKKDEVNALDQERRTPLHAAAWLGDVHIMDLLISAGANVNAKDHVWLTPLHRAAASRNERAVGLLLRKGADV 100
Cdd:COG0666    1 LLLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221  101 TARDKYWQTPLHIAAANRATRCVETLLPHVSSLNMADRTGRAPLHHAAQSGYQEMVKLLLNKGANLSASDKKDRQPIHWA 180
Cdd:COG0666   81 NAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221  181 AYLGHLEVVKLLVSQGSDKSCKDKRGYTPLHAAAASGHVDVVKYLLRNGAEIDEPNAFGNTALHVACYTGQEAVANELVN 260
Cdd:COG0666  161 AANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLE 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 66392221  261 RGANVNQPNHRGYTPLHLAAVSTNGALCLELLVNNGADVN 300
Cdd:COG0666  241 AGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAA 280
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
5-276 3.48e-48

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 173.60  E-value: 3.48e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221    5 NISDQPPLVQAIFNRNADEVKLFLHKKDEVNALDQERRTPLHAAAWLGDVHIMDLLISAGANVNAKDHVWLTPLHRAAAS 84
Cdd:COG0666   18 LLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARN 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   85 RNERAVGLLLRKGADVTARDKYWQTPLHIAAANRATRCVETLLPHVSSLNMADRTGRAPLHHAAQSGYQEMVKLLLNKGA 164
Cdd:COG0666   98 GDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGA 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221  165 NLSASDKKDRQPIHWAAYLGHLEVVKLLVSQGSDKSCKDKRGYTPLHAAAASGHVDVVKYLLRNGAEIDEPNAFGNTALH 244
Cdd:COG0666  178 DVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALL 257

                        250       260       270
                 ....*....|....*....|....*....|..
gi 66392221  245 VACYTGQEAVANELVNRGANVNQPNHRGYTPL 276
Cdd:COG0666  258 LAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
186-493 1.33e-39

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 148.95  E-value: 1.33e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221  186 LEVVKLLVSQGSDKSCKDKRGYTPLHAAAASGHVDVVKYLLRNGAEIDEPNAFGNTALHVACYTGQEAVANELVNRGANV 265
Cdd:COG0666    1 LLLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221  266 NQPNHRGYTPLHLAAVSTNGALcLELLVNNGADVNMQSKEGKSPLHMAAIHGRFTRSQILIQNGGEIDCVDRYGNTPLHV 345
Cdd:COG0666   81 NAKDDGGNTLLHAAARNGDLEI-VKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221  346 AAKYGHELLISTLMTNGADTARQGIHGMFPLHLAVLYGSSDCCRKLlssgqlysivlsmskehvLSAGFDINTPDNFGRT 425
Cdd:COG0666  160 AAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLL------------------LEAGADVNAKDNDGKT 221

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 66392221  426 CLHAAASGGNIECLNLLLSSGADMNKKDKFGRTPLHYAAANGRYQCVVVLVGAGAEVNERDRSGCTPL 493
Cdd:COG0666  222 ALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
PHA03095 PHA03095
ankyrin-like protein; Provisional
 53-317 7.63e-37

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 145.55  E-value: 7.63e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221    53 DVHIMDLLISAGANVNAKDHVWLTPLHRAAASRNE---RAVGLLLRKGADVTARDKYWQTPLHIAAANRAT-RCVETLLP 128
Cdd:PHA03095   26 TVEEVRRLLAAGADVNFRGEYGKTPLHLYLHYSSEkvkDIVRLLLEAGADVNAPERCGFTPLHLYLYNATTlDVIKLLIK 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   129 HVSSLNMADRTGRAPLH-HAA-QSGYQEMVKLLLNKGANLSASDKKDRQPIHwaAYLGH----LEVVKLLVSQGSDKSCK 202
Cdd:PHA03095  106 AGADVNAKDKVGRTPLHvYLSgFNINPKVIRLLLRKGADVNALDLYGMTPLA--VLLKSrnanVELLRLLIDAGADVYAV 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   203 DKRGYTPLHAAAASGHVD--VVKYLLRNGAEIDEPNAFGNTALHV-ACYTGQEA--VANeLVNRGANVNQPNHRGYTPLH 277
Cdd:PHA03095  184 DDRFRSLLHHHLQSFKPRarIVRELIRAGCDPAATDMLGNTPLHSmATGSSCKRslVLP-LLIAGISINARNRYGQTPLH 262

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 66392221   278 LAAVSTNGALCLELLvNNGADVNMQSKEGKSPLHMAAIHG 317
Cdd:PHA03095  263 YAAVFNNPRACRRLI-ALGADINAVSSDGNTPLSLMVRNN 301
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
289-602 1.62e-36

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 140.09  E-value: 1.62e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221  289 LELLVNNGADVNMQSKEGKSPLHMAAIHGRFTRSQILIQNGGEIDCVDRYGNTPLHVAAKYGHELLISTLMTNGADTARQ 368
Cdd:COG0666    4 LLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAK 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221  369 GIHGMFPLHLAVLYGSSDCCRKLLSsgqlysivlsmskehvlsAGFDINTPDNFGRTCLHAAASGGNIECLNLLLSSGAD 448
Cdd:COG0666   84 DDGGNTLLHAAARNGDLEIVKLLLE------------------AGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGAD 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221  449 MNKKDKFGRTPLHYAAANGRYQCVVVLVGAGAEVNERDRSGCTPLHYsaastafcrtdrphASTHQNQEdgekesflCVE 528
Cdd:COG0666  146 VNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHL--------------AAENGHLE--------IVK 203

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 66392221  529 HLLDNGADPCLCNTKGYSAVHYAAAHGNKQNLELLLEMcfNTLGDKESNGSISPLHLAVESGHWECVTVLIESG 602
Cdd:COG0666  204 LLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEA--GADLNAKDKDGLTALLLAAAAGAALIVKLLLLAL 275
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
530-771 1.89e-33

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 130.84  E-value: 1.89e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221  530 LLDNGADPCLCNTKGYSAVHYAAAHGNKQNLELLLEMCFNTlgDKESNGSISPLHLAVESGHWECVTVLIESGVCVDVCD 609
Cdd:COG0666   40 LLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADI--NAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARD 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221  610 PVGRSVLYLASQRGHSRCVELLLSQSAScLLAEHRSKWGPLHVAAANGHSECLRMLLcsEGGADlVNVTDAEGQTPLMLA 689
Cdd:COG0666  118 KDGETPLHLAAYNGNLEIVKLLLEAGAD-VNAQDNDGNTPLHLAAANGNLEIVKLLL--EAGAD-VNARDNDGETPLHLA 193

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221  690 VLGGHTDCVHLLLERGACPDMKDRRGRTALHRGAVMGREDCLTALLSHNVSVLSRDFQGRSALHLAASCGHADILSNLLS 769
Cdd:COG0666  194 AENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLL 273


                 ..
gi 66392221  770 AA 771
Cdd:COG0666  274 AL 275
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
541-808 6.16e-33

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 129.69  E-value: 6.16e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221  541 NTKGYSAVHYAAAHGNKQNLELLLEMCFNTLGDKESNGSISPLHLAVESGHWECVTVLIESGVCVDVCDPVGRSVLYLAS 620
Cdd:COG0666   16 LLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAA 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221  621 QRGHSRCVELLLSQSAScLLAEHRSKWGPLHVAAANGHSECLRMLLcsEGGADlVNVTDAEGQTPLMLAVLGGHTDCVHL 700
Cdd:COG0666   96 RNGDLEIVKLLLEAGAD-VNARDKDGETPLHLAAYNGNLEIVKLLL--EAGAD-VNAQDNDGNTPLHLAAANGNLEIVKL 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221  701 LLERGACPDMKDRRGRTALHRGAVMGREDCLTALLSHNVSVLSRDFQGRSALHLAASCGHADILSNLLSAADhsqpQDPL 780
Cdd:COG0666  172 LLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGA----DLNA 247

                        250       260
                 ....*....|....*....|....*...
gi 66392221  781 TDRHGYTPAHWAAYHGHEDCLEVLLELK 808
Cdd:COG0666  248 KDKDGLTALLLAAAAGAALIVKLLLLAL 275
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 53-384 1.67e-32

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 135.58  E-value: 1.67e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221    53 DVHIMDLLISAGANVNAKDHVWLTPLHRAAASRNERAVGLLLRKGADVTARDKYWQTPLHIAAANRATRCVETLLPHVSS 132
Cdd:PHA02876  157 ELLIAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNRSN 236

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   133 LNMADRTgrapLHHAAQSGYQEMVKLLLNKGANLSASDKKDRQPIHWAAYLGHL-EVVKLLVSQGSDKSCKDKRGYTPLH 211
Cdd:PHA02876  237 INKNDLS----LLKAIRNEDLETSLLLYDAGFSVNSIDDCKNTPLHHASQAPSLsRLVPKLLERGADVNAKNIKGETPLY 312

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   212 AAAASGH-VDVVKYLLRNGAEIDEPNAFGNTALHVACYTGQ-EAVANELVNRGANVNQPNHRGYTPLHLAAVStNGALCL 289
Cdd:PHA02876  313 LMAKNGYdTENIRTLIMLGADVNAADRLYITPLHQASTLDRnKDIVITLLELGANVNARDYCDKTPIHYAAVR-NNVVII 391

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   290 ELLVNNGADVNMQSKEGKSPLHMaAIHGR--FTRSQILIQNGGEIDCVDRYGNTPLHVAAKYGHEL-LISTLMTNGADTA 366
Cdd:PHA02876  392 NTLLDYGADIEALSQKIGTALHF-ALCGTnpYMSVKTLIDRGANVNSKNKDLSTPLHYACKKNCKLdVIEMLLDNGADVN 470

                         330
                  ....*....|....*...
gi 66392221   367 RQGIHGMFPLHLAVLYGS 384
Cdd:PHA02876  471 AINIQNQYPLLIALEYHG 488
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 25-364 2.31e-32

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 134.81  E-value: 2.31e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221    25 KLFLHKKDEVNALDQERRTPLHAAAWLGDVHIMDLLISAGANVNAKDHVWLTPLHRAAASRNERAVGLLLRKGADVTARD 104
Cdd:PHA02876  162 EMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNRSNINKND 241

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   105 kywqtpLHIAAANRATRCVETLLPHVS--SLNMADRTGRAPLHHAAQS-GYQEMVKLLLNKGANLSASDKKDRQPIHWAA 181
Cdd:PHA02876  242 ------LSLLKAIRNEDLETSLLLYDAgfSVNSIDDCKNTPLHHASQApSLSRLVPKLLERGADVNAKNIKGETPLYLMA 315

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   182 YLGH-LEVVKLLVSQGSDKSCKDKRGYTPLHAAAA-SGHVDVVKYLLRNGAEIDEPNAFGNTALHVACYTGQEAVANELV 259
Cdd:PHA02876  316 KNGYdTENIRTLIMLGADVNAADRLYITPLHQASTlDRNKDIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLL 395

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   260 NRGANVNQPNHRGYTPLHLAAVSTNGALCLELLVNNGADVNMQSKEGKSPLHMAAIHG-RFTRSQILIQNGGEIDCVDRY 338
Cdd:PHA02876  396 DYGADIEALSQKIGTALHFALCGTNPYMSVKTLIDRGANVNSKNKDLSTPLHYACKKNcKLDVIEMLLDNGADVNAINIQ 475

                         330       340
                  ....*....|....*....|....*.
gi 66392221   339 GNTPLHVAAKYghELLISTLMTNGAD 364
Cdd:PHA02876  476 NQYPLLIALEY--HGIVNILLHYGAE 499
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 66-301 4.65e-32

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 130.17  E-value: 4.65e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221    66 NVNAKDHVwlTPLHRAAASRNERAVGLLLRKGADVTARDKYWQTPLHIAAANRA--TRCVET---LLPHVSSLNMADRTG 140
Cdd:PHA03100   29 DYSYKKPV--LPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLSNIKYnlTDVKEIvklLLEYGANVNAPDNNG 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   141 RAPLHHAAQ--SGYQEMVKLLLNKGANLSASDKKDRQPIHWAAYLGH--LEVVKLLVSQGSDKSCKDKrgytplhaaaas 216
Cdd:PHA03100  107 ITPLLYAISkkSNSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKidLKILKLLIDKGVDINAKNR------------ 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   217 ghvdvVKYLLRNGAEIDEPNAFGNTALHVACYTGQEAVANELVNRGANVNQPNHRGYTPLHLAAVSTNGALcLELLVNNG 296
Cdd:PHA03100  175 -----VNYLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEI-FKLLLNNG 248


                  ....*
gi 66392221   297 ADVNM 301
Cdd:PHA03100  249 PSIKT 253
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
580-853 4.90e-31

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 123.91  E-value: 4.90e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221  580 ISPLHLAVESGHWECVTVLIESGVCVDVCDPVGRSVLYLASQRGHSRCVELLLSQSAScLLAEHRSKWGPLHVAAANGHS 659
Cdd:COG0666   22 ALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGAD-INAKDDGGNTLLHAAARNGDL 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221  660 ECLRMLLcsEGGADlVNVTDAEGQTPLMLAVLGGHTDCVHLLLERGACPDMKDRRGRTALHRGAVMGREDCLTALLSHNV 739
Cdd:COG0666  101 EIVKLLL--EAGAD-VNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGA 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221  740 SVLSRDFQGRSALHLAASCGHADILSNLLSA-ADHSqpqdpLTDRHGYTPAHWAAYHGHEDCLEVLLE-LKPCSIQEGNP 817
Cdd:COG0666  178 DVNARDNDGETPLHLAAENGHLEIVKLLLEAgADVN-----AKDNDGKTALDLAAENGNLEIVKLLLEaGADLNAKDKDG 252

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 66392221  818 FTPLHCALINGHSGSAELLLESSVCNSLVNIRDAKG 853
Cdd:COG0666  253 LTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTL 288
PHA03095 PHA03095
ankyrin-like protein; Provisional
 186-472 8.78e-31

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 127.45  E-value: 8.78e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   186 LEVVKLLVSQGSDKSCKDKRGYTPLHAAAASGH---VDVVKYLLRNGAEIDEPNAFGNTALHV-ACYTGQEAVANELVNR 261
Cdd:PHA03095   27 VEEVRRLLAAGADVNFRGEYGKTPLHLYLHYSSekvKDIVRLLLEAGADVNAPERCGFTPLHLyLYNATTLDVIKLLIKA 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   262 GANVNQPNHRGYTPLH--LAAVSTNgALCLELLVNNGADVNMQSKEGKSPLHmaaIHGRFTRSQI-----LIQNGGEIDC 334
Cdd:PHA03095  107 GADVNAKDKVGRTPLHvyLSGFNIN-PKVIRLLLRKGADVNALDLYGMTPLA---VLLKSRNANVellrlLIDAGADVYA 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   335 VDRYGNTPLHVAAKYGH--ELLISTLMTNGADTARQGIHGMFPLHLAVLYGSsdcCRKllssgqlySIVLSmskehVLSA 412
Cdd:PHA03095  183 VDDRFRSLLHHHLQSFKprARIVRELIRAGCDPAATDMLGNTPLHSMATGSS---CKR--------SLVLP-----LLIA 246

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   413 GFDINTPDNFGRTCLHAAASGGNIECLNLLLSSGADMNKKDKFGRTPLHYAAANGRYQCV 472
Cdd:PHA03095  247 GISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLSLMVRNNNGRAV 306
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 25-364 1.11e-30

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 126.62  E-value: 1.11e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221    25 KLFLHKKDEVNALDQERRTPLHAAAWLGDVHIMDLLISAGANVNAKDHVWLTPLHRAAASRNERAVGLLLRKGADVTard 104
Cdd:PHA02874   19 KIIKNKGNCINISVDETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIDNGVDTS--- 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   105 kywqtplhiaaanratrcvetLLPhVSSLNmadrtgraplhhaaqsgyQEMVKLLLNKGANLSASDKKDRQPIHWAAYLG 184
Cdd:PHA02874   96 ---------------------ILP-IPCIE------------------KDMIKTILDCGIDVNIKDAELKTFLHYAIKKG 135

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   185 HLEVVKLLVSQGSDKSCKDKRGYTPLHAAAASGHVDVVKYLLRNGAEIDEPNAFGNTALHVACYTGQEAVANELVNRGAN 264
Cdd:PHA02874  136 DLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLIDHGNH 215

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   265 VNQPNHRGYTPLHLAAVSTNGAlcLELLVNNgADVNMQSKEGKSPLHMaAIHGRFTRS--QILIQNGGEIDCVDRYGNTP 342
Cdd:PHA02874  216 IMNKCKNGFTPLHNAIIHNRSA--IELLINN-ASINDQDIDGSTPLHH-AINPPCDIDiiDILLYHKADISIKDNKGENP 291

                         330       340
                  ....*....|....*....|....*...
gi 66392221   343 LHVAAKYGH------ELLISTLMTNGAD 364
Cdd:PHA02874  292 IDTAFKYINkdpvikDIIANAVLIKEAD 319
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 19-266 2.15e-30

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 125.16  E-value: 2.15e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221    19 RNADEVKLFLHKKDEVN-ALDQERRTPLHAAAWLGDVHIMDLLISAGANVNAKDHVWLTPLH-----RAAASRNERAVGL 92
Cdd:PHA03100   12 IIKVKNIKYIIMEDDLNdYSYKKPVLPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHylsniKYNLTDVKEIVKL 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221    93 LLRKGADVTARDKYWQTPLHIAAANRA--TRCVETLLPHVSSLNMADRTGRAPLHHAAQSGYQ--EMVKLLLNKGANLsa 168
Cdd:PHA03100   92 LLEYGANVNAPDNNGITPLLYAISKKSnsYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKIdlKILKLLIDKGVDI-- 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   169 sDKKDRqpihwaaylghlevVKLLVSQGSDKSCKDKRGYTPLHAAAASGHVDVVKYLLRNGAEIDEPNAFGNTALHVACY 248
Cdd:PHA03100  170 -NAKNR--------------VNYLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAIL 234

                         250
                  ....*....|....*...
gi 66392221   249 TGQEAVANELVNRGANVN 266
Cdd:PHA03100  235 NNNKEIFKLLLNNGPSIK 252
PHA03095 PHA03095
ankyrin-like protein; Provisional
 219-555 3.72e-30

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 125.52  E-value: 3.72e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   219 VDVVKYLLRNGAEIDEPNAFGNTALHVACYTGQEAVA---NELVNRGANVNQPNHRGYTPLHLAAVSTNGALCLELLVNN 295
Cdd:PHA03095   27 VEEVRRLLAAGADVNFRGEYGKTPLHLYLHYSSEKVKdivRLLLEAGADVNAPERCGFTPLHLYLYNATTLDVIKLLIKA 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   296 GADVNMQSKEGKSPLHmAAIHGRFTRS---QILIQNGGEIDCVDRYGNTPLHVaakygheLLISTLMTngADTARqgihg 372
Cdd:PHA03095  107 GADVNAKDKVGRTPLH-VYLSGFNINPkviRLLLRKGADVNALDLYGMTPLAV-------LLKSRNAN--VELLR----- 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   373 MFPLHLAVLYGSSDCCRKLLSSGQLY-----SIVlsmskEHVLSAGFDINTPDNFGRTCLHAAASGGNIECLNL--LLSS 445
Cdd:PHA03095  172 LLIDAGADVYAVDDRFRSLLHHHLQSfkpraRIV-----RELIRAGCDPAATDMLGNTPLHSMATGSSCKRSLVlpLLIA 246

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   446 GADMNKKDKFGRTPLHYAAANGRYQCVVVLVGAGAEVNERDRSGCTPL------HYSAASTAFCRTdRPHASTHQNQedg 519
Cdd:PHA03095  247 GISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLslmvrnNNGRAVRAALAK-NPSAETVAAT--- 322

                         330       340       350
                  ....*....|....*....|....*....|....*.
gi 66392221   520 ekesflcVEHLLDNGADPCLCNTKgySAVHYAAAHG 555
Cdd:PHA03095  323 -------LNTASVAGGDIPSDATR--LCVAKVVLRG 349
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
672-951 1.14e-29

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 120.06  E-value: 1.14e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221  672 ADLVNVTDAEGQTPLMLAVLGGHTDCVHLLLERGACPDMKDRRGRTALHRGAVMGREDCLTALLSHNVSVLSRDFQGRSA 751
Cdd:COG0666   11 LLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTL 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221  752 LHLAASCGHADILSNLLSAADhsqpqDP-LTDRHGYTPAHWAAYHGHEDCLEVLLELK-PCSIQEGNPFTPLHCALINGH 829
Cdd:COG0666   91 LHAAARNGDLEIVKLLLEAGA-----DVnARDKDGETPLHLAAYNGNLEIVKLLLEAGaDVNAQDNDGNTPLHLAAANGN 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221  830 SGSAELLLESsvcNSLVNIRDAKGRTPLHAAAVAEDVAGLQLVLRQGADIDAVDHSGRSALMVAADYGQSGAVALLLhRA 909
Cdd:COG0666  166 LEIVKLLLEA---GADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLL-EA 241

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 66392221  910 KADLSLLDVNKNTALHLACSKAHEMCAMLILKEIHNPILINA 951
Cdd:COG0666  242 GADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALL 283
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 155-536 1.80e-29

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 125.95  E-value: 1.80e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   155 MVKLLLNKGANLSASDKKDRQPIHWAAYLGHLEVVKLLVSQGSDKSCKDKRGYTPLHAAAASGHVDVVKYLLRNGAEIDE 234
Cdd:PHA02876  160 IAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNRSNINK 239

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   235 P-----NAFGNTALHVACYtgqeavaneLVNRGANVNQPNHRGYTPLHLAAVSTNGALCLELLVNNGADVNMQSKEGKSP 309
Cdd:PHA02876  240 NdlsllKAIRNEDLETSLL---------LYDAGFSVNSIDDCKNTPLHHASQAPSLSRLVPKLLERGADVNAKNIKGETP 310

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   310 LHMAAIHGRFTRS-QILIQNGGEIDCVDRYGNTPLHVAakyghelliSTLMTNGadtarqgihgmfplhlavlygssdcc 388
Cdd:PHA02876  311 LYLMAKNGYDTENiRTLIMLGADVNAADRLYITPLHQA---------STLDRNK-------------------------- 355

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   389 rkllssgqlySIVLSMskehvLSAGFDINTPDNFGRTCLHAAASGGNIECLNLLLSSGADMNKKDKFGRTPLHYA-AANG 467
Cdd:PHA02876  356 ----------DIVITL-----LELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALHFAlCGTN 420

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 66392221   468 RYQCVVVLVGAGAEVNERDRSGCTPLHYSAASTafCRTDrphasthqnqedgekesflCVEHLLDNGAD 536
Cdd:PHA02876  421 PYMSVKTLIDRGANVNSKNKDLSTPLHYACKKN--CKLD-------------------VIEMLLDNGAD 468
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
700-993 5.14e-29

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 118.13  E-value: 5.14e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221  700 LLLERGACPDMKDRRGRTALHRGAVMGREDCLTALLSHNVSVLSRDFQGRSALHLAASCGHADILSNLLSAADHsqpqDP 779
Cdd:COG0666    6 LLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGAD----IN 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221  780 LTDRHGYTPAHWAAYHGHEDCLEVLLELKP-CSIQEGNPFTPLHCALINGHSGSAELLLESsvcNSLVNIRDAKGRTPLH 858
Cdd:COG0666   82 AKDDGGNTLLHAAARNGDLEIVKLLLEAGAdVNARDKDGETPLHLAAYNGNLEIVKLLLEA---GADVNAQDNDGNTPLH 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221  859 AAAVAEDVAGLQLVLRQGADIDAVDHSGRSALMVAADYGQSGAVALLLhRAKADLSLLDVNKNTALHLACSKAHEMCAML 938
Cdd:COG0666  159 LAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLL-EAGADVNAKDNDGKTALDLAAENGNLEIVKL 237

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 66392221  939 ILKEIHNpilINATNSMLQMPLHIAARNGLATVVQALLNRGATVLAVDEEGHTPA 993
Cdd:COG0666  238 LLEAGAD---LNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 4-313 2.28e-27

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 116.60  E-value: 2.28e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221     4 LNISDQ---PPLVQAIFNRNADEVKLFLHKKDEVNALDQERRTPLHAAAWLGDVHIMDLLISAGANVNakdhvwLTPLhr 80
Cdd:PHA02874   28 INISVDettTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIDNGVDTS------ILPI-- 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221    81 aaASRNERAVGLLLRKGADVTARDKYWQTPLHIAAANRATRCVETLLPHVSSLNMADRTGRAPLHHAAQSGYQEMVKLLL 160
Cdd:PHA02874  100 --PCIEKDMIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLL 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   161 NKGANLSASDKKDRQPIHWAAYLGHLEVVKLLVSQGSDKSCKDKRGYTPLHAAaasghvdvvkyLLRNGAEIdepnafgn 240
Cdd:PHA02874  178 EKGAYANVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNA-----------IIHNRSAI-------- 238

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 66392221   241 talhvacytgqeavanELVNRGANVNQPNHRGYTPLHLAAVSTNGALCLELLVNNGADVNMQSKEGKSPLHMA 313
Cdd:PHA02874  239 ----------------ELLINNASINDQDIDGSTPLHHAINPPCDIDIIDILLYHKADISIKDNKGENPIDTA 295
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
778-1010 2.60e-27

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 113.13  E-value: 2.60e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221  778 DPLTDRHGYTPAHWAAYHGHEDCLEVLLELKPCSIQEGNPFTPLHCALINGHSGSAELLLESSVCNslVNIRDAKGRTPL 857
Cdd:COG0666   14 ALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGAD--INAKDDGGNTLL 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221  858 HAAAVAEDVAGLQLVLRQGADIDAVDHSGRSALMVAADYGQSGAVALLLhRAKADLSLLDVNKNTALHLACSKAH-EMCA 936
Cdd:COG0666   92 HAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLL-EAGADVNAQDNDGNTPLHLAAANGNlEIVK 170

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 66392221  937 MLilkeIHNPILINATNSMLQMPLHIAARNGLATVVQALLNRGATVLAVDEEGHTPALACASNKAVADCLALIL 1010
Cdd:COG0666  171 LL----LEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLE 240
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 23-313 8.62e-27

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 115.36  E-value: 8.62e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221    23 EVKLFLHKKDEVNALDQERRTPLHAAAWLGDVHIMDLLISAGANVNAKDHVWLTPLHRAAASRNERAVGLLLRkgaDVTA 102
Cdd:PHA02878   19 YIEYIDHTENYSTSASLIPFIPLHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHIICKEPNKLGMKEMIR---SINK 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   103 RD-KYWQTPLHIAAANRATRCVETLLphvssLNMADRTGRAPLHHAAQSGYQ-----EMVKLLLNKGANLSASDK-KDRQ 175
Cdd:PHA02878   96 CSvFYTLVAIKDAFNNRNVEIFKIIL-----TNRYKNIQTIDLVYIDKKSKDdiieaEITKLLLSYGADINMKDRhKGNT 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   176 PIHWAAYLGHLEVVKLLVSQGSDKSCKDKRGYTPLHAAAASGHVDVVKYLLRNGAEIDEPNAFGNTALHVAC-YTGQEAV 254
Cdd:PHA02878  171 ALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHISVgYCKDYDI 250

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   255 ANELVNRGANVN-QPNHRGYTPLHLAAVSTNGalcLELLVNNGADVNMQSKEGKSPLHMA 313
Cdd:PHA02878  251 LKLLLEHGVDVNaKSYILGLTALHSSIKSERK---LKLLLEYGADINSLNSYKLTPLSSA 307
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 157-463 3.97e-26

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 112.75  E-value: 3.97e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   157 KLLLNKGANLSASDKKDRQPIHWAAYLGHLEVVKLLVSQGSDKSCKDKRGYTPLHAAAASGHVDVVKYLLRNGAEidepn 236
Cdd:PHA02874   19 KIIKNKGNCINISVDETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIDNGVD----- 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   237 afgNTALHVACYtgQEAVANELVNRGANVNQPNHRGYTPLHLAaVSTNGALCLELLVNNGADVNMQSKEGKSPLHMAAIH 316
Cdd:PHA02874   94 ---TSILPIPCI--EKDMIKTILDCGIDVNIKDAELKTFLHYA-IKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKH 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   317 GRFTRSQILIQNGGEIDCVDRYGNTPLHVAAKYGHELLISTLMTNGADTARQGIHGMFPLHLAVLYGSSdccrkllssgq 396
Cdd:PHA02874  168 NFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIHNRS----------- 236

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 66392221   397 lySIVLSMSKEhvlsagfDINTPDNFGRTCLHAAAS-GGNIECLNLLLSSGADMNKKDKFGRTPLHYA 463
Cdd:PHA02874  237 --AIELLINNA-------SINDQDIDGSTPLHHAINpPCDIDIIDILLYHKADISIKDNKGENPIDTA 295
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
761-1010 6.24e-26

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 109.27  E-value: 6.24e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221  761 ADILSNLLSAADHSQPQDPLTDRHGYTPAHWAAYHGHEDCLEVLLELKPCSIQEGNP--FTPLHCALINGHSGSAELLLE 838
Cdd:COG0666   29 ALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDggNTLLHAAARNGDLEIVKLLLE 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221  839 SsvcNSLVNIRDAKGRTPLHAAAVAEDVAGLQLVLRQGADIDAVDHSGRSALMVAADYGQSGAVALLLHrAKADLSLLDV 918
Cdd:COG0666  109 A---GADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLE-AGADVNARDN 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221  919 NKNTALHLACSKAH-EMCAMLILKEIHnpilINATNSMLQMPLHIAARNGLATVVQALLNRGATVLAVDEEGHTPALACA 997
Cdd:COG0666  185 DGETPLHLAAENGHlEIVKLLLEAGAD----VNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAA 260

                        250
                 ....*....|...
gi 66392221  998 SNKAVADCLALIL 1010
Cdd:COG0666  261 AAGAALIVKLLLL 273
PHA03095 PHA03095
ankyrin-like protein; Provisional
 258-557 1.25e-25

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 111.66  E-value: 1.25e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   258 LVNRGANVNQPNHRGYTPLHLAaVSTNGALCLE---LLVNNGADVNMQSKEGKSPLHMAAIHGRFTR-SQILIQNGGEID 333
Cdd:PHA03095   33 LLAAGADVNFRGEYGKTPLHLY-LHYSSEKVKDivrLLLEAGADVNAPERCGFTPLHLYLYNATTLDvIKLLIKAGADVN 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   334 CVDRYGNTPLHVaakyghellistlmtngadtarqgihgmfplhlavlYGSSDCCRkllssgqlYSIVLSMskehvLSAG 413
Cdd:PHA03095  112 AKDKVGRTPLHV------------------------------------YLSGFNIN--------PKVIRLL-----LRKG 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   414 FDINTPDNFGRTCLHA--AASGGNIECLNLLLSSGADMNKKDKFGRTPLHYAAAN--GRYQCVVVLVGAGAEVNERDRSG 489
Cdd:PHA03095  143 ADVNALDLYGMTPLAVllKSRNANVELLRLLIDAGADVYAVDDRFRSLLHHHLQSfkPRARIVRELIRAGCDPAATDMLG 222

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 66392221   490 CTPLHYSAASTAFCRTDrphasthqnqedgekesflcVEHLLDNGADPCLCNTKGYSAVHYAAAHGNK 557
Cdd:PHA03095  223 NTPLHSMATGSSCKRSL--------------------VLPLLIAGISINARNRYGQTPLHYAAVFNNP 270
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 143-455 2.23e-24

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 107.44  E-value: 2.23e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   143 PLHHAAQSGYQEMVKLLLNKGANLSASDKKDRQPIHWAAYLGH-----LEVVKLLVSQGSDKSCKDKRGYTPLHAAAA-- 215
Cdd:PHA03100   38 PLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLSNIKYnltdvKEIVKLLLEYGANVNAPDNNGITPLLYAISkk 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   216 SGHVDVVKYLLrngaeidepnafgntalhvacytgqeavanelvNRGANVNQPNHRGYTPLHLAAVSTNGAL-CLELLVN 294
Cdd:PHA03100  118 SNSYSIVEYLL---------------------------------DNGANVNIKNSDGENLLHLYLESNKIDLkILKLLID 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   295 NGADVNMQskegksplhmaaihgrfTRSQILIQNGGEIDCVDRYGNTPLHVAAKYGHELLISTLMTNGADtarqgihgmf 374
Cdd:PHA03100  165 KGVDINAK-----------------NRVNYLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGAN---------- 217

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   375 plhlavlygssdccrkllssgqlysivlsmskehvlsagfdINTPDNFGRTCLHAAASGGNIECLNLLLSSGADMNKKDK 454
Cdd:PHA03100  218 -----------------------------------------PNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSIKTIIE 256


                  .
gi 66392221   455 F 455
Cdd:PHA03100  257 T 257
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 186-466 2.56e-24

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 107.06  E-value: 2.56e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   186 LEVVKLLVSQGSDKSCKDKRGYTPLHAAAASGHVDVVKYLLRNGAEIDEPNAFGNTALHVAcyTGQEAVANE-------L 258
Cdd:PHA03100   15 VKNIKYIIMEDDLNDYSYKKPVLPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYL--SNIKYNLTDvkeivklL 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   259 VNRGANVNQPNHRGYTPLHLAAVSTNGALCL-ELLVNNGADVNMQSKEGKSPLHMAA--IHGRFTRSQILIQNGGEIDCV 335
Cdd:PHA03100   93 LEYGANVNAPDNNGITPLLYAISKKSNSYSIvEYLLDNGANVNIKNSDGENLLHLYLesNKIDLKILKLLIDKGVDINAK 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   336 DRYgntplhvaakyghELLISTlmtngadtarqgihgmfplhlavlygssdccrkllssgqlysivlsmskehvlsaGFD 415
Cdd:PHA03100  173 NRV-------------NYLLSY-------------------------------------------------------GVP 184

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 66392221   416 INTPDNFGRTCLHAAASGGNIECLNLLLSSGADMNKKDKFGRTPLHYAAAN 466
Cdd:PHA03100  185 INIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILN 235
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 12-332 9.51e-24

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 107.84  E-value: 9.51e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221    12 LVQAIFNRNADEVKLFLHKKDEVNALDQERRTPLHaaawlgdvhimdllisaganvnakdhvwltplHRAAASRNERAVG 91
Cdd:PHA02876  244 LLKAIRNEDLETSLLLYDAGFSVNSIDDCKNTPLH--------------------------------HASQAPSLSRLVP 291

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221    92 LLLRKGADVTARDKYWQTPLHIAAAN-RATRCVETLLPHVSSLNMADRTGRAPLHHAAQ-SGYQEMVKLLLNKGANLSAS 169
Cdd:PHA02876  292 KLLERGADVNAKNIKGETPLYLMAKNgYDTENIRTLIMLGADVNAADRLYITPLHQASTlDRNKDIVITLLELGANVNAR 371

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   170 DKKDRQPIHWaaylghlevvkllvsqgsdksckdkrgytplhaAAASGHVDVVKYLLRNGAEIDEPNAFGNTALHVA-CY 248
Cdd:PHA02876  372 DYCDKTPIHY---------------------------------AAVRNNVVIINTLLDYGADIEALSQKIGTALHFAlCG 418

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   249 TGQEAVANELVNRGANVNQPNHRGYTPLHLAAVSTNGALCLELLVNNGADVNMQSKEGKSPLHMAAihGRFTRSQILIQN 328
Cdd:PHA02876  419 TNPYMSVKTLIDRGANVNSKNKDLSTPLHYACKKNCKLDVIEMLLDNGADVNAINIQNQYPLLIAL--EYHGIVNILLHY 496


                  ....
gi 66392221   329 GGEI 332
Cdd:PHA02876  497 GAEL 500
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 290-619 1.26e-22

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 102.35  E-value: 1.26e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   290 ELLVNNGADVNMQSKEGKSPLHMAAIHGRFTRSQILIQNGGEIDCVDRYGNTPLHVAAKYGHELLISTLMTNGADTArqg 369
Cdd:PHA02874   19 KIIKNKGNCINISVDETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIDNGVDTS--- 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   370 ihgMFPlhlavlygssdccrkllssgqlysiVLSMSKEHV---LSAGFDINTPDNFGRTCLHAAASGGNIECLNLLLSSG 446
Cdd:PHA02874   96 ---ILP-------------------------IPCIEKDMIktiLDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYG 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   447 ADMNKKDKFGRTPLHYAAANGRYQCVVVLVGAGAEVNERDRSGCTPLHYSAastafcrtdrphasthqnqedgEKESFLC 526
Cdd:PHA02874  148 ADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAA----------------------EYGDYAC 205

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   527 VEHLLDNGADPCLCNTKGYSAVHYAAAHgNKQNLELLLEMcfNTLGDKESNGSiSPLHLAVEsghWEC----VTVLIESG 602
Cdd:PHA02874  206 IKLLIDHGNHIMNKCKNGFTPLHNAIIH-NRSAIELLINN--ASINDQDIDGS-TPLHHAIN---PPCdidiIDILLYHK 278

                         330
                  ....*....|....*..
gi 66392221   603 VCVDVCDPVGRSVLYLA 619
Cdd:PHA02874  279 ADISIKDNKGENPIDTA 295
Ank_2 pfam12796
Ankyrin repeats (3 copies);
177-269 7.69e-22

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 90.95  E-value: 7.69e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221    177 IHWAAYLGHLEVVKLLVSQGSDKSCKDKRGYTPLHAAAASGHVDVVKYLLRNgAEIDEPNaFGNTALHVACYTGQEAVAN 256
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVK 78

                           90
                   ....*....|...
gi 66392221    257 ELVNRGANVNQPN 269
Cdd:pfam12796   79 LLLEKGADINVKD 91
Ank_2 pfam12796
Ankyrin repeats (3 copies);
144-236 1.03e-21

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 90.56  E-value: 1.03e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221    144 LHHAAQSGYQEMVKLLLNKGANLSASDKKDRQPIHWAAYLGHLEVVKLLVSQGsDKSCKDKrGYTPLHAAAASGHVDVVK 223
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHA-DVNLKDN-GRTALHYAARSGHLEIVK 78

                           90
                   ....*....|...
gi 66392221    224 YLLRNGAEIDEPN 236
Cdd:pfam12796   79 LLLEKGADINVKD 91
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 143-380 9.37e-21

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 96.87  E-value: 9.37e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   143 PLHHAAQSGYQEMVKLLLNKGANLSASDKKDRQPIHWAAYLGHLEVVKLLVSQGSdkscKDKRGYT--PLHAAAASGHVD 220
Cdd:PHA02878   40 PLHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHIICKEPNKLGMKEMIRSIN----KCSVFYTlvAIKDAFNNRNVE 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   221 VVKYLLRNG---------AEIDEPNAFGNTalhvacytgQEAVANELVNRGANVNQPN-HRGYTPLHLAAVSTNGALcLE 290
Cdd:PHA02878  116 IFKIILTNRykniqtidlVYIDKKSKDDII---------EAEITKLLLSYGADINMKDrHKGNTALHYATENKDQRL-TE 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   291 LLVNNGADVNMQSKEGKSPLHMAAIHGRFTRSQILIQNGGEIDCVDRYGNTPLHVAAKYGHEL-LISTLMTNGAD-TARQ 368
Cdd:PHA02878  186 LLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHISVGYCKDYdILKLLLEHGVDvNAKS 265

                         250
                  ....*....|..
gi 66392221   369 GIHGMFPLHLAV 380
Cdd:PHA02878  266 YILGLTALHSSI 277
PHA03095 PHA03095
ankyrin-like protein; Provisional
 24-227 3.31e-19

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 92.01  E-value: 3.31e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221    24 VKLFLHKKDEVNALDQERRTPLHAaaWLG----DVHIMDLLISAGANVNAKDHVWLTPLHRAAASRN--ERAVGLLLRKG 97
Cdd:PHA03095  100 IKLLIKAGADVNAKDKVGRTPLHV--YLSgfniNPKVIRLLLRKGADVNALDLYGMTPLAVLLKSRNanVELLRLLIDAG 177

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221    98 ADVTARDKYWQTPLHIAAANRATR--CVETLLPHVSSLNMADRTGRAPLHHAAQSGYQEMVKL--LLNKGANLSASDKKD 173
Cdd:PHA03095  178 ADVYAVDDRFRSLLHHHLQSFKPRarIVRELIRAGCDPAATDMLGNTPLHSMATGSSCKRSLVlpLLIAGISINARNRYG 257

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 66392221   174 RQPIHWAAYLGHLEVVKLLVSQGSDKSCKDKRGYTPLHAAAASGHVDVVKYLLR 227
Cdd:PHA03095  258 QTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLSLMVRNNNGRAVRAALA 311
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 24-194 3.82e-18

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 88.78  E-value: 3.82e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221    24 VKLFLHKKDEVNALDQER-RTPLHAAAWLGDVHIMDLLISAGANVNAKDHVWLTPLHRAAASRNERAVGLLLRKGADVTA 102
Cdd:PHA02878  150 TKLLLSYGADINMKDRHKgNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDA 229

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   103 RDKYWQTPLHIAAAN-RATRCVETLLPHVSSLNMADRT-GRAPLHHAAQSgyQEMVKLLLNKGANLSASDKKDRQPIHWA 180
Cdd:PHA02878  230 RDKCGNTPLHISVGYcKDYDILKLLLEHGVDVNAKSYIlGLTALHSSIKS--ERKLKLLLEYGADINSLNSYKLTPLSSA 307

                         170
                  ....*....|....*.
gi 66392221   181 A--YLGhLEVVKLLVS 194
Cdd:PHA02878  308 VkqYLC-INIGRILIS 322
Ank_2 pfam12796
Ankyrin repeats (3 copies);
78-170 3.87e-18

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 80.16  E-value: 3.87e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221     78 LHRAAASRNERAVGLLLRKGADVTARDKYWQTPLHIAAANRATRCVETLLPHVsSLNMADRtGRAPLHHAAQSGYQEMVK 157
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHA-DVNLKDN-GRTALHYAARSGHLEIVK 78

                           90
                   ....*....|...
gi 66392221    158 LLLNKGANLSASD 170
Cdd:pfam12796   79 LLLEKGADINVKD 91
Ank_2 pfam12796
Ankyrin repeats (3 copies);
111-203 6.36e-18

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 79.77  E-value: 6.36e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221    111 LHIAAANRATRCVETLLPHVSSLNMADRTGRAPLHHAAQSGYQEMVKLLLNKGAnlSASDKKDRQPIHWAAYLGHLEVVK 190
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHAD--VNLKDNGRTALHYAARSGHLEIVK 78

                           90
                   ....*....|...
gi 66392221    191 LLVSQGSDKSCKD 203
Cdd:pfam12796   79 LLLEKGADINVKD 91
Ank_2 pfam12796
Ankyrin repeats (3 copies);
650-745 8.85e-18

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 79.39  E-value: 8.85e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221    650 LHVAAANGHSECLRMLLcsEGGADlVNVTDAEGQTPLMLAVLGGHTDCVHLLLERgACPDMKDRrGRTALHRGAVMGRED 729
Cdd:pfam12796    1 LHLAAKNGNLELVKLLL--ENGAD-ANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDN-GRTALHYAARSGHLE 75

                           90
                   ....*....|....*.
gi 66392221    730 CLTALLSHNVSVLSRD 745
Cdd:pfam12796   76 IVKLLLEKGADINVKD 91
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 109-301 1.36e-17

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 86.58  E-value: 1.36e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   109 TPLHIAAANRATRCVETLLPHVSSLNMADRTGRAPLHHAAQSGYQEMVKLLLNkgANLSASD---KKDRQPIHWAAYLGH 185
Cdd:PHA02875   37 SPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEELLD--LGKFADDvfyKDGMTPLHLATILKK 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   186 LEVVKLLVSQGSDKSCKDKRGYTPLHAAAASGHVDVVKYLLRNGAEIDEPNAFGNTALHVACYTGQEAVANELVNRGANV 265
Cdd:PHA02875  115 LDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANI 194

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 66392221   266 NQPNHRGYTPLHLAAVSTNGALCLELLVNNGADVNM 301
Cdd:PHA02875  195 DYFGKNGCVAALCYAIENNKIDIVRLFIKRGADCNI 230
Ank_2 pfam12796
Ankyrin repeats (3 copies);
376-486 2.90e-17

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 77.85  E-value: 2.90e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221    376 LHLAVLYGSSDCCRKLLSSGqlysivlsmskehvlsagFDINTPDNFGRTCLHAAASGGNIECLNLLLSSgADMNKKDKf 455
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENG------------------ADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDN- 60

                           90       100       110
                   ....*....|....*....|....*....|.
gi 66392221    456 GRTPLHYAAANGRYQCVVVLVGAGAEVNERD 486
Cdd:pfam12796   61 GRTALHYAARSGHLEIVKLLLEKGADINVKD 91
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 233-463 3.32e-17

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 86.09  E-value: 3.32e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   233 DEPNAFGNTALHVACYTGQEAVANELVNRGANVNQPNHRGYTPLHLAAVSTN---------------------------- 284
Cdd:PHA02878   31 TSASLIPFIPLHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHIICKEPNklgmkemirsinkcsvfytlvaikdafn 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   285 -----------------------------------GALCLELLVNNGADVNMQSKE-GKSPLHMAAIHGRFTRSQILIQN 328
Cdd:PHA02878  111 nrnveifkiiltnrykniqtidlvyidkkskddiiEAEITKLLLSYGADINMKDRHkGNTALHYATENKDQRLTELLLSY 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   329 GGEIDCVDRYGNTPLHVAAKYGHELLISTLMTNGADTARQGIHGMFPLHLAVlygssdccrkllssGQLYSI-VLSMSKE 407
Cdd:PHA02878  191 GANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHISV--------------GYCKDYdILKLLLE 256

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 66392221   408 HvlsaGFDINTPDNF-GRTCLHAAASGGNIecLNLLLSSGADMNKKDKFGRTPLHYA 463
Cdd:PHA02878  257 H----GVDVNAKSYIlGLTALHSSIKSERK--LKLLLEYGADINSLNSYKLTPLSSA 307
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 51-236 7.90e-17

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 85.69  E-value: 7.90e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221    51 LGDVHIMDLLISAGANvnAKDHVWLTPLHRAAASRNERAVGLLLRKGADVTARDKYWQTPLHIAAANRATRCVETLLPHV 130
Cdd:PLN03192  504 LHDLNVGDLLGDNGGE--HDDPNMASNLLTVASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHA 581

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   131 SSLNMADRTGRAPLHHAAQSGYQEMVKLLLNKGanlSASDKKDRQPIH-WAAYLGHLEVVKLLVSQGSDKSCKDKRGYTP 209
Cdd:PLN03192  582 CNVHIRDANGNTALWNAISAKHHKIFRILYHFA---SISDPHAAGDLLcTAAKRNDLTAMKELLKQGLNVDSEDHQGATA 658

                         170       180
                  ....*....|....*....|....*..
gi 66392221   210 LHAAAASGHVDVVKYLLRNGAEIDEPN 236
Cdd:PLN03192  659 LQVAMAEDHVDMVRLLIMNGADVDKAN 685
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 11-198 1.25e-16

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 83.50  E-value: 1.25e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221    11 PLVQAIFNRNADEVKLFLHKKDEVNALDQERRTPLHAAAWLGDVHIMDLLISAGANVNakDHVW---LTPLHRAAASRNE 87
Cdd:PHA02875   38 PIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEELLDLGKFAD--DVFYkdgMTPLHLATILKKL 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221    88 RAVGLLLRKGA--DVTARDKYwqTPLHIAAANRATRCVETLLPHVSSLNMADRTGRAPLHHAAQSGYQEMVKLLLNKGAN 165
Cdd:PHA02875  116 DIMKLLIARGAdpDIPNTDKF--SPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGAN 193

                         170       180       190
                  ....*....|....*....|....*....|....
gi 66392221   166 LS-ASDKKDRQPIHWAAYLGHLEVVKLLVSQGSD 198
Cdd:PHA02875  194 IDyFGKNGCVAALCYAIENNKIDIVRLFIKRGAD 227
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 516-907 2.95e-16

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 83.57  E-value: 2.95e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   516 QEDGEKESFLCVEHLLDNGADPCLCNTKGYSAVHYAAAHGNKQNLELLL----EMCFNTLGDkesngsISPLHLAVESGH 591
Cdd:PHA02876  150 KERIQQDELLIAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLsygaDVNIIALDD------LSVLECAVDSKN 223

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   592 WECVTVLIESGVCVDVCDpvgrsVLYLASQRGHSRCVELLLSQSASCLLAEHRSKWGPLHVAA-ANGHSECLRMLLcsEG 670
Cdd:PHA02876  224 IDTIKAIIDNRSNINKND-----LSLLKAIRNEDLETSLLLYDAGFSVNSIDDCKNTPLHHASqAPSLSRLVPKLL--ER 296

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   671 GADlVNVTDAEGQTPLMLAVLGGH-TDCVHLLLERGACPDMKDRRGRTALHRGAVMGR-EDCLTALLSHNVSVLSRDFQG 748
Cdd:PHA02876  297 GAD-VNAKNIKGETPLYLMAKNGYdTENIRTLIMLGADVNAADRLYITPLHQASTLDRnKDIVITLLELGANVNARDYCD 375

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   749 RSALHLAASCGHADILSNLLsaaDHSQPQDPLTDRHGyTPAHWAAYHghedclevllelkpcsiqeGNPFTPLHCALING 828
Cdd:PHA02876  376 KTPIHYAAVRNNVVIINTLL---DYGADIEALSQKIG-TALHFALCG-------------------TNPYMSVKTLIDRG 432

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   829 HSgsaelllessvcnslVNIRDAKGRTPLHAAA---VAEDVagLQLVLRQGADIDAVDHSGRSALMVAADYgqSGAVALL 905
Cdd:PHA02876  433 AN---------------VNSKNKDLSTPLHYACkknCKLDV--IEMLLDNGADVNAINIQNQYPLLIALEY--HGIVNIL 493


                  ..
gi 66392221   906 LH 907
Cdd:PHA02876  494 LH 495
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 425-706 1.76e-15

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 80.09  E-value: 1.76e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   425 TCLHAAASGGNIECLNLLLSSGADMNKKDKFGRTPLHYAAaNGRY------QCVVVLVGAGAEVNERDRSGCTPLHYsAA 498
Cdd:PHA03100   37 LPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLS-NIKYnltdvkEIVKLLLEYGANVNAPDNNGITPLLY-AI 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   499 STafcrtdrphasthqnqedgEKESFLCVEHLLDNGADPCLCNTKGYSAVHYAaahgnkqnlellLEMCFNTLgdkesng 578
Cdd:PHA03100  115 SK-------------------KSNSYSIVEYLLDNGANVNIKNSDGENLLHLY------------LESNKIDL------- 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   579 sisplhlavesghwECVTVLIESGVCVDVCDPvgrsvlylasqrghsrcVELLLSQSASCLLAEHRSkWGPLHVAAANGH 658
Cdd:PHA03100  157 --------------KILKLLIDKGVDINAKNR-----------------VNYLLSYGVPINIKDVYG-FTPLHYAVYNNN 204

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 66392221   659 SECLRMLLcsEGGADlVNVTDAEGQTPLMLAVLGGHTDCVHLLLERGA 706
Cdd:PHA03100  205 PEFVKYLL--DLGAN-PNLVNKYGDTPLHIAILNNNKEIFKLLLNNGP 249
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 141-365 2.40e-15

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 79.65  E-value: 2.40e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   141 RAPLHHAAQSGYQEMVKLLLNKGANLSASDKKDRQPIHWAAYLGHLEVVKLLVSQGSDKSCKDKRGYTPLHAAAASGHVD 220
Cdd:PHA02875    3 QVALCDAILFGELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVK 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   221 VVKYLLRNGAEIDEpnAF---GNTALHVACYTGQEAVANELVNRGANVNQPNHRGYTPLHLAAVSTNGALcLELLVNNGA 297
Cdd:PHA02875   83 AVEELLDLGKFADD--VFykdGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKG-IELLIDHKA 159

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 66392221   298 DVNMQSKEGKSPLHMAAIHGRFTRSQILIQNGGEIDCVDRYGNTPLHVAAKYGHEL-LISTLMTNGADT 365
Cdd:PHA02875  160 CLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNGCVAALCYAIENNKIdIVRLFIKRGADC 228
Ank_2 pfam12796
Ankyrin repeats (3 copies);
427-537 2.44e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 72.46  E-value: 2.44e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221    427 LHAAASGGNIECLNLLLSSGADMNKKDKFGRTPLHYAAANGRYQCVVVLVgAGAEVNERDrSGCTPLHYSAAStafcrtd 506
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLL-EHADVNLKD-NGRTALHYAARS------- 71

                           90       100       110
                   ....*....|....*....|....*....|.
gi 66392221    507 rphasthqNQEDgekesflCVEHLLDNGADP 537
Cdd:pfam12796   72 --------GHLE-------IVKLLLEKGADI 87
Ank_2 pfam12796
Ankyrin repeats (3 copies);
583-679 2.69e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 72.07  E-value: 2.69e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221    583 LHLAVESGHWECVTVLIESGVCVDVCDPVGRSVLYLASQRGHSRCVELLLSQSASCLLAEHRSkwgPLHVAAANGHSECL 662
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLKDNGRT---ALHYAARSGHLEIV 77

                           90
                   ....*....|....*..
gi 66392221    663 RMLLCSegGADlVNVTD 679
Cdd:pfam12796   78 KLLLEK--GAD-INVKD 91
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 246-493 3.05e-15

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 79.26  E-value: 3.05e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   246 ACYTGQEAVANELVNRGANVNQPNHRGYTPLHLAaVSTNGALCLELLVNNGADVNMQSKEGKSPLHMAAIHGRFTRSQIL 325
Cdd:PHA02875    9 AILFGELDIARRLLDIGINPNFEIYDGISPIKLA-MKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEEL 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   326 IQNGGEI-DCVDRYGNTPLHVAAKYGHELLISTLMTNGADTarqgihgmfplhlavlygssdccrkllssgqlysivlsm 404
Cdd:PHA02875   88 LDLGKFAdDVFYKDGMTPLHLATILKKLDIMKLLIARGADP--------------------------------------- 128

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   405 skehvlsagfDINTPDNFgrTCLHAAASGGNIECLNLLLSSGADMNKKDKFGRTPLHYAAANGRYQCVVVLVGAGAEVNE 484
Cdd:PHA02875  129 ----------DIPNTDKF--SPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDY 196


                  ....*....
gi 66392221   485 RDRSGCTPL 493
Cdd:PHA02875  197 FGKNGCVAA 205
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 140-335 3.13e-15

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 79.26  E-value: 3.13e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   140 GRAPLHHAAQSGYQEMVKLLLNKGANLSASDKKDRQPIHWAAYLGHLEVVKLLVSQGsdKSCKD---KRGYTPLHAAAAS 216
Cdd:PHA02875   35 GISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEELLDLG--KFADDvfyKDGMTPLHLATIL 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   217 GHVDVVKYLLRNGAEIDEPNAFGNTALHVACYTGQEAVANELVNRGANVNQPNHRGYTPLHLAAVSTNGALClELLVNNG 296
Cdd:PHA02875  113 KKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAIC-KMLLDSG 191

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 66392221   297 ADVNMQSKEGKSPLHMAAI-HGRFTRSQILIQNGGEIDCV 335
Cdd:PHA02875  192 ANIDYFGKNGCVAALCYAIeNNKIDIVRLFIKRGADCNIM 231
PHA03095 PHA03095
ankyrin-like protein; Provisional
 662-1010 3.65e-15

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 79.30  E-value: 3.65e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   662 LRMLLcsEGGADlVNVTDAEGQTPLMLAVLGGHTDC---VHLLLERGACPDMKDRRGRTALHRGAVMG-REDCLTALLSH 737
Cdd:PHA03095   30 VRRLL--AAGAD-VNFRGEYGKTPLHLYLHYSSEKVkdiVRLLLEAGADVNAPERCGFTPLHLYLYNAtTLDVIKLLIKA 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   738 NVSVLSRDFQGRSALH--LAASCGHADILSNLLSA-ADhsqPQDplTDRHGYTPAHwaAYHGHEDC-LEVL--LELKPCS 811
Cdd:PHA03095  107 GADVNAKDKVGRTPLHvyLSGFNINPKVIRLLLRKgAD---VNA--LDLYGMTPLA--VLLKSRNAnVELLrlLIDAGAD 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   812 I--QEGNPFTPLHCALINGHSgSAELLLESSVCNSLVNIRDAKGRTPLHAAAVAEDVAGLQLV--LRQGADIDAVDHSGR 887
Cdd:PHA03095  180 VyaVDDRFRSLLHHHLQSFKP-RARIVRELIRAGCDPAATDMLGNTPLHSMATGSSCKRSLVLplLIAGISINARNRYGQ 258

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   888 SALMVAADYGQSGAVALLLhRAKADLSLLDVNKNTALHLACSKAHEMCAMLILKEIHNPILINATnsmlqmpLHIAARNG 967
Cdd:PHA03095  259 TPLHYAAVFNNPRACRRLI-ALGADINAVSSDGNTPLSLMVRNNNGRAVRAALAKNPSAETVAAT-------LNTASVAG 330

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 66392221   968 LATVVQALLNRGATVLAVDEEGHTPALACASNKA-VADCLALIL 1010
Cdd:PHA03095  331 GDIPSDATRLCVAKVVLRGAFSLLPEPIRAYHADfIRECEAEIA 374
Ank_2 pfam12796
Ankyrin repeats (3 copies);
616-712 4.50e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 71.69  E-value: 4.50e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221    616 LYLASQRGHSRCVELLLSQSASCLLAEHRsKWGPLHVAAANGHSECLRmLLCSEGGADLVNvtdaEGQTPLMLAVLGGHT 695
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKN-GRTALHLAAKNGHLEIVK-LLLEHADVNLKD----NGRTALHYAARSGHL 74

                           90
                   ....*....|....*..
gi 66392221    696 DCVHLLLERGACPDMKD 712
Cdd:pfam12796   75 EIVKLLLEKGADINVKD 91
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 628-896 5.81e-15

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 78.47  E-value: 5.81e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   628 VELLLSQSASCLLAEHRSKWGPLHVAAANGHSECLRMLLCSegGADlVNVTDAEGQTPLMLAVLGGHTDCVHLLLERGA- 706
Cdd:PHA02874   17 IEKIIKNKGNCINISVDETTTPLIDAIRSGDAKIVELFIKH--GAD-INHINTKIPHPLLTAIKIGAHDIIKLLIDNGVd 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   707 -----CPDM-----------------KDRRGRTALHRGAVMGREDCLTALLSHNVSVLSRDFQGRSALHLAASCGHADIL 764
Cdd:PHA02874   94 tsilpIPCIekdmiktildcgidvniKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDII 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   765 SNLLSAADHSQpqdpLTDRHGYTPAHWAAYHGHEDCLEVLLE-LKPCSIQEGNPFTPLHCALINGHSgSAELLLEssvcN 843
Cdd:PHA02874  174 KLLLEKGAYAN----VKDNNGESPLHNAAEYGDYACIKLLIDhGNHIMNKCKNGFTPLHNAIIHNRS-AIELLIN----N 244

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 66392221   844 SLVNIRDAKGRTPLHAA---AVAEDVagLQLVLRQGADIDAVDHSGRSALMVAADY 896
Cdd:PHA02874  245 ASINDQDIDGSTPLHHAinpPCDIDI--IDILLYHKADISIKDNKGENPIDTAFKY 298
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 201-445 7.41e-15

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 78.90  E-value: 7.41e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221  201 CKDKRGY-TPLHAAAASGHVDVVKYLLR-NGAEIDEPNAFGNTALHVACYTGQEAVANELVNRGAN-VNQPN----HRGY 273
Cdd:cd22192   11 LQQKRISeSPLLLAAKENDVQAIKKLLKcPSCDLFQRGALGETALHVAALYDNLEAAVVLMEAAPElVNEPMtsdlYQGE 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221  274 TPLHLAAVSTNGALcLELLVNNGADVNMQSKEGKSplhmaaihgrFTRSQiliqnggeiDCVDRYGNTPLHVAAKYGHEL 353
Cdd:cd22192   91 TALHIAVVNQNLNL-VRELIARGADVVSPRATGTF----------FRPGP---------KNLIYYGEHPLSFAACVGNEE 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221  354 LISTLMTNGADTARQGIHGMFPLHLAVLYGSSDccrkllSSGQLYSIVLSMSKE---HVLSagfdiNTPDNFGRTCLHAA 430
Cdd:cd22192  151 IVRLLIEHGADIRAQDSLGNTVLHILVLQPNKT------FACQMYDLILSYDKEddlQPLD-----LVPNNQGLTPFKLA 219

                        250
                 ....*....|....*
gi 66392221  431 ASGGNIECLNLLLSS 445
Cdd:cd22192  220 AKEGNIVMFQHLVQK 234
PHA03095 PHA03095
ankyrin-like protein; Provisional
 436-796 7.65e-15

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 78.53  E-value: 7.65e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   436 IECLNLLLSSGADMNKKDKFGRTPLHYAAANGRYQC---VVVLVGAGAEVNERDRSGCTPLHYsaastafcrtdrphast 512
Cdd:PHA03095   27 VEEVRRLLAAGADVNFRGEYGKTPLHLYLHYSSEKVkdiVRLLLEAGADVNAPERCGFTPLHL----------------- 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   513 hqnqedgekesflcvehlldngadpclcntkgysavhYaaahgnkqnlellleMCFNTLgdkesngsisplhlavesghW 592
Cdd:PHA03095   90 -------------------------------------Y---------------LYNATT--------------------L 97

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   593 ECVTVLIESGVCVDVCDPVGRSVL--YLASQRGHSRCVELLLsqsascllaehrskwgplhvaaanghseclrmllcsEG 670
Cdd:PHA03095   98 DVIKLLIKAGADVNAKDKVGRTPLhvYLSGFNINPKVIRLLL------------------------------------RK 141

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   671 GADlVNVTDAEGQTPlmLAVLGGHTDC----VHLLLERGACPDMKDRRGRTALHRGA--VMGREDCLTALLSHNVSVLSR 744
Cdd:PHA03095  142 GAD-VNALDLYGMTP--LAVLLKSRNAnvelLRLLIDAGADVYAVDDRFRSLLHHHLqsFKPRARIVRELIRAGCDPAAT 218

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 66392221   745 DFQGRSALHLAA---SCGHADILSNLLSAADhsqpqDPLTDRHGYTPAHWAAYHG 796
Cdd:PHA03095  219 DMLGNTPLHSMAtgsSCKRSLVLPLLIAGIS-----INARNRYGQTPLHYAAVFN 268
Ank_2 pfam12796
Ankyrin repeats (3 copies);
343-453 1.03e-14

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 70.53  E-value: 1.03e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221    343 LHVAAKYGHELLISTLMTNGADTARQGIHGMFPLHLAVLYGSSDCCRKLLSSgqlysivlsmskehvlsagFDINTPDNf 422
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-------------------ADVNLKDN- 60

                           90       100       110
                   ....*....|....*....|....*....|.
gi 66392221    423 GRTCLHAAASGGNIECLNLLLSSGADMNKKD 453
Cdd:pfam12796   61 GRTALHYAARSGHLEIVKLLLEKGADINVKD 91
Ank_2 pfam12796
Ankyrin repeats (3 copies);
12-104 3.19e-14

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 68.99  E-value: 3.19e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221     12 LVQAIFNRNADEVKLFLHKKDEVNALDQERRTPLHAAAWLGDVHIMDLLISaGANVNAKDHVWlTPLHRAAASRNERAVG 91
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKDNGR-TALHYAARSGHLEIVK 78

                           90
                   ....*....|...
gi 66392221     92 LLLRKGADVTARD 104
Cdd:pfam12796   79 LLLEKGADINVKD 91
Ank_2 pfam12796
Ankyrin repeats (3 copies);
686-769 5.89e-14

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 68.22  E-value: 5.89e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221    686 LMLAVLGGHTDCVHLLLERGACPDMKDRRGRTALHRGAVMGREDCLTALLSHNvsVLSRDFQGRSALHLAASCGHADILS 765
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHA--DVNLKDNGRTALHYAARSGHLEIVK 78


                   ....
gi 66392221    766 NLLS 769
Cdd:pfam12796   79 LLLE 82
PHA02946 PHA02946
ankyin-like protein; Provisional
 207-460 1.10e-13

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 74.70  E-value: 1.10e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   207 YTPLHAAAASGHVDVvkylLRNGAEIDEPNafGNT-ALHVACYTG--QEAVANELVNRGANVNQPNHRGYTPLHLAAVST 283
Cdd:PHA02946   10 YLSLYAKYNSKNLDV----FRNMLQAIEPS--GNYhILHAYCGIKglDERFVEELLHRGYSPNETDDDGNYPLHIASKIN 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   284 NGALcLELLVNNGADVNMQSKEGKSPLHMAAIHGR--FTRSQILIQNGGEI-DCVDRYGNTPLhVAAKYGHELLISTLMT 360
Cdd:PHA02946   84 NNRI-VAMLLTHGADPNACDKQHKTPLYYLSGTDDevIERINLLVQYGAKInNSVDEEGCGPL-LACTDPSERVFKKIMS 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   361 NGadtarqgihgmFPLHLAVLYGSSDCCRKLLSSGQLYSIVLSMSKehvlsAGFDINTPDNFGRTCLHAAASG--GNIEC 438
Cdd:PHA02946  162 IG-----------FEARIVDKFGKNHIHRHLMSDNPKASTISWMMK-----LGISPSKPDHDGNTPLHIVCSKtvKNVDI 225

                         250       260
                  ....*....|....*....|..
gi 66392221   439 LNLLLSSgADMNKKDKFGRTPL 460
Cdd:PHA02946  226 INLLLPS-TDVNKQNKFGDSPL 246
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 529-736 1.26e-13

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 74.26  E-value: 1.26e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   529 HLLDNGADPCLCNTKGYSAVHYAAAHGNKQNLELLleMCFNTLGDKESNGSISPLHLAVESGHWECVTVLIESGVCV-DV 607
Cdd:PHA02875   20 RLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLL--MKHGAIPDVKYPDIESELHDAVEEGDVKAVEELLDLGKFAdDV 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   608 CDPVGRSVLYLASQRGHSRCVELLLSQSASCLLAeHRSKWGPLHVAAANGHSECLRMLLCSEGgadLVNVTDAEGQTPLM 687
Cdd:PHA02875   98 FYKDGMTPLHLATILKKLDIMKLLIARGADPDIP-NTDKFSPLHLAVMMGDIKGIELLIDHKA---CLDIEDCCGCTPLI 173

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 66392221   688 LAVLGGHTDCVHLLLERGACPDMKDRRGRTALHRGAVM-GREDCLTALLS 736
Cdd:PHA02875  174 IAMAKGDIAICKMLLDSGANIDYFGKNGCVAALCYAIEnNKIDIVRLFIK 223
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 64-284 1.38e-13

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 75.05  E-value: 1.38e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   64 GANVNAKDHVWLTPLHRAAASRNERAVG-LLLRKGADVTARDKYWQTPLHIAAANRATRCVETLLPHVSSL-NMADRT-- 139
Cdd:cd22192    7 ELHLLQQKRISESPLLLAAKENDVQAIKkLLKCPSCDLFQRGALGETALHVAALYDNLEAAVVLMEAAPELvNEPMTSdl 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221  140 --GRAPLHHAAQSGYQEMVKLLLNKGANLSasdkKDRqpihwaaylghleVVKLLVSQGSDKSCKdkRGYTPLHAAAASG 217
Cdd:cd22192   87 yqGETALHIAVVNQNLNLVRELIARGADVV----SPR-------------ATGTFFRPGPKNLIY--YGEHPLSFAACVG 147

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 66392221  218 HVDVVKYLLRNGAEIDEPNAFGNTALHVACYTGQEAVANE----LVNRGANVNQ------PNHRGYTPLHLAAVSTN 284
Cdd:cd22192  148 NEEIVRLLIEHGADIRAQDSLGNTVLHILVLQPNKTFACQmydlILSYDKEDDLqpldlvPNNQGLTPFKLAAKEGN 224
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 10-139 1.46e-13

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 73.93  E-value: 1.46e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221    10 PPLVQAIFNR--NADEVKLFLHKKDEVNALDQERRTPLHAAAW--LGDVHIMDLLISAGANVNAKDHVWL---------- 75
Cdd:PHA03100  108 TPLLYAISKKsnSYSIVEYLLDNGANVNIKNSDGENLLHLYLEsnKIDLKILKLLIDKGVDINAKNRVNYllsygvpini 187

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221    76 ------TPLHRAAASRNERAVGLLLRKGADVTARDKYWQTPLHIAAANRATRCVETLLPHVSSLNMADRT 139
Cdd:PHA03100  188 kdvygfTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSIKTIIET 257
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 11-169 2.11e-13

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 74.71  E-value: 2.11e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221    11 PLVQA-IFNRNADEVKLFLHKKDEVNALDQERRTPLHAAAWLGDVHIMDLLISAGANVNAKDHVWLTPLHRAAASRNE-R 88
Cdd:PHA02876  344 PLHQAsTLDRNKDIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALHFALCGTNPyM 423

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221    89 AVGLLLRKGADVTARDKYWQTPLHIAAANRAT-RCVETLLPHVSSLNMADRTGRAPLHHAAqsGYQEMVKLLLNKGANLS 167
Cdd:PHA02876  424 SVKTLIDRGANVNSKNKDLSTPLHYACKKNCKlDVIEMLLDNGADVNAINIQNQYPLLIAL--EYHGIVNILLHYGAELR 501


                  ..
gi 66392221   168 AS 169
Cdd:PHA02876  502 DS 503
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 407-714 2.30e-13

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 74.33  E-value: 2.30e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   407 EHVLSAGFDINTPDNFGRTCLHAAASGGNIECLNLLLSSGADMNKKDKFGRTPLHYAA---------------------- 464
Cdd:PHA02876  162 EMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVdsknidtikaiidnrsninknd 241

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   465 -------ANGRYQCVVVLVGAGAEVNERDRSGCTPLHYSAASTAFCRTdrphasthqnqedgekesflcVEHLLDNGADP 537
Cdd:PHA02876  242 lsllkaiRNEDLETSLLLYDAGFSVNSIDDCKNTPLHHASQAPSLSRL---------------------VPKLLERGADV 300

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   538 CLCNTKGYSAVHYAAAHG-NKQNLELLLEMCFNTlgDKESNGSISPLHLAVESGHW-ECVTVLIESGVCVDVCDPVGRSV 615
Cdd:PHA02876  301 NAKNIKGETPLYLMAKNGyDTENIRTLIMLGADV--NAADRLYITPLHQASTLDRNkDIVITLLELGANVNARDYCDKTP 378

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   616 LYLASQRGHSRCVELL---------LSQSASCLL------------------------AEHRSKWGPLHVAAANG-HSEC 661
Cdd:PHA02876  379 IHYAAVRNNVVIINTLldygadieaLSQKIGTALhfalcgtnpymsvktlidrganvnSKNKDLSTPLHYACKKNcKLDV 458

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|...
gi 66392221   662 LRMLLcsEGGADlVNVTDAEGQTPLMLAVlgGHTDCVHLLLERGAcpDMKDRR 714
Cdd:PHA02876  459 IEMLL--DNGAD-VNAINIQNQYPLLIAL--EYHGIVNILLHYGA--ELRDSR 504
Ank_2 pfam12796
Ankyrin repeats (3 copies);
310-395 4.34e-13

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 65.91  E-value: 4.34e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221    310 LHMAAIHGRFTRSQILIQNGGEIDCVDRYGNTPLHVAAKYGH----ELLISTLMTNGADtarqgiHGMFPLHLAVLYGSS 385
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHleivKLLLEHADVNLKD------NGRTALHYAARSGHL 74

                           90
                   ....*....|
gi 66392221    386 DCCRKLLSSG 395
Cdd:pfam12796   75 EIVKLLLEKG 84
Ank_2 pfam12796
Ankyrin repeats (3 copies);
276-364 5.76e-13

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 65.52  E-value: 5.76e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221    276 LHLAAVStNGALCLELLVNNGADVNMQSKEGKSPLHMAAIHGRFTRSQILIQNGgEIDCVDrYGNTPLHVAAKYGHELLI 355
Cdd:pfam12796    1 LHLAAKN-GNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHA-DVNLKD-NGRTALHYAARSGHLEIV 77


                   ....*....
gi 66392221    356 STLMTNGAD 364
Cdd:pfam12796   78 KLLLEKGAD 86
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 8-266 7.13e-13

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 71.95  E-value: 7.13e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221     8 DQPPLVQAIFNRNADEVKLFLHKKDEVNALDQERRTPLHAAAWLGDVHIMDLLISAGANVNAKDHVWLTPLHRAAASRNE 87
Cdd:PHA02875    2 DQVALCDAILFGELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221    88 RAVGLLLRKGA---DVTARDkywqtplhiaaanratrcvetllphvsslnmadrtGRAPLHHAAQSGYQEMVKLLLNKGA 164
Cdd:PHA02875   82 KAVEELLDLGKfadDVFYKD-----------------------------------GMTPLHLATILKKLDIMKLLIARGA 126

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   165 NLSASDKKDRQPIHWAAYLGHLEVVKLLVSQGSDKSCKDKRGYTPLHAAAASGHVDVVKYLLRNGAEIDEPNAFGNTALh 244
Cdd:PHA02875  127 DPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNGCVAA- 205

                         250       260
                  ....*....|....*....|....*
gi 66392221   245 vACYTGQEA---VANELVNRGANVN 266
Cdd:PHA02875  206 -LCYAIENNkidIVRLFIKRGADCN 229
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 3-118 7.75e-13

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 72.22  E-value: 7.75e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221     3 VLNISDQPPLVQAIFNRNADEVKLFLHKKDEVNALDQERRTPLH-AAAWLGDVHIMDLLISAGANVNAKDHVW-LTPLHr 80
Cdd:PHA02878  196 IPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHiSVGYCKDYDILKLLLEHGVDVNAKSYILgLTALH- 274

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 66392221    81 aAASRNERAVGLLLRKGADVTARDKYWQTPLHIAAANR 118
Cdd:PHA02878  275 -SSIKSERKLKLLLEYGADINSLNSYKLTPLSSAVKQY 311
Ank_2 pfam12796
Ankyrin repeats (3 copies);
45-137 9.28e-13

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 65.14  E-value: 9.28e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221     45 LHAAAWLGDVHIMDLLISAGANVNAKDHVWLTPLHRAAASRNERAVGLLLRKgADVTARDKYWqTPLHIAAANRATRCVE 124
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDNGR-TALHYAARSGHLEIVK 78

                           90
                   ....*....|...
gi 66392221    125 TLLPHVSSLNMAD 137
Cdd:pfam12796   79 LLLEKGADINVKD 91
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 424-719 1.16e-12

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 71.53  E-value: 1.16e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   424 RTCLHAaasgGNIECL-NLLLSSGADMNKKDKFGRTPLHYAAANGRYQCVVVLVGAGAEVNERDRSGCTPLhysaaSTAF 502
Cdd:PHA02874    6 RMCIYS----GDIEAIeKIIKNKGNCINISVDETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPL-----LTAI 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   503 crTDRPHASTHQNQEDGEKESFL---CVEH-----LLDNGADPCLCNTKGYSAVHYAAAHGNKQNLELLLEMCFNtLGDK 574
Cdd:PHA02874   77 --KIGAHDIIKLLIDNGVDTSILpipCIEKdmiktILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGAD-VNIE 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   575 ESNGSIsPLHLAVESGHWECVTVLIESGVCVDVCDPVGRSVLYLASQRGHSRCVELLLSQSaSCLLAEHRSKWGPLHVAA 654
Cdd:PHA02874  154 DDNGCY-PIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLIDHG-NHIMNKCKNGFTPLHNAI 231

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 66392221   655 ANGHSeCLRMLLCSEGgadlVNVTDAEGQTPLMLAV-LGGHTDCVHLLLERGACPDMKDRRGRTAL 719
Cdd:PHA02874  232 IHNRS-AIELLINNAS----INDQDIDGSTPLHHAInPPCDIDIIDILLYHKADISIKDNKGENPI 292
PHA02946 PHA02946
ankyin-like protein; Provisional
 121-312 1.29e-12

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 71.24  E-value: 1.29e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   121 RCVETLLPHVSSLNMADRTGRAPLHHAAQSGYQEMVKLLLNKGANLSASDKKDRQPIHWAAYLGH--LEVVKLLVSQGSD 198
Cdd:PHA02946   53 RFVEELLHRGYSPNETDDDGNYPLHIASKINNNRIVAMLLTHGADPNACDKQHKTPLYYLSGTDDevIERINLLVQYGAK 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   199 -KSCKDKRGYTPLHAAAASGHvDVVKYLLRNGAEIDEPNAFGNTAL--HVACYTGQEAVANELVNRGANVNQPNHRGYTP 275
Cdd:PHA02946  133 iNNSVDEEGCGPLLACTDPSE-RVFKKIMSIGFEARIVDKFGKNHIhrHLMSDNPKASTISWMMKLGISPSKPDHDGNTP 211

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 66392221   276 LHLAAVSTNGALCLELLVNNGADVNMQSKEGKSPLHM 312
Cdd:PHA02946  212 LHIVCSKTVKNVDIINLLLPSTDVNKQNKFGDSPLTL 248
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 594-980 2.24e-12

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 71.25  E-value: 2.24e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   594 CVTVLIESGVCVDVC-DPVGRSVLYLAS-----QRGHSRCVELLLSQSASCLLAEHRSKwGPLHVAAANGHSECLRMLLC 667
Cdd:PHA02876  121 CIHILKEAISGNDIHyDKINESIEYMKLikeriQQDELLIAEMLLEGGADVNAKDIYCI-TPIHYAAERGNAKMVNLLLS 199

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   668 SegGADlVNVTDAEGQTPLMLAVLGGHTDCVHLLLergacpDMKDRRGRTALHRGAVMGREDCLTALLSHNV--SVLSRD 745
Cdd:PHA02876  200 Y--GAD-VNIIALDDLSVLECAVDSKNIDTIKAII------DNRSNINKNDLSLLKAIRNEDLETSLLLYDAgfSVNSID 270

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   746 FQGRSALHLAAscgHADILSNLLSAADHSQPQDPLTDRHGYTPAHWAAYHGH--EDCLEVLLELKPCSIQEGNPFTPLHC 823
Cdd:PHA02876  271 DCKNTPLHHAS---QAPSLSRLVPKLLERGADVNAKNIKGETPLYLMAKNGYdtENIRTLIMLGADVNAADRLYITPLHQ 347

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   824 A-LINGHSGSAELLLEssvCNSLVNIRDAKGRTPLHAAAVAEDVAGLQLVLRQGADIDAVDHSGRSALMVAAdYGQS--G 900
Cdd:PHA02876  348 AsTLDRNKDIVITLLE---LGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALHFAL-CGTNpyM 423

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   901 AVALLLHRAkADLSLLDVNKNTALHLACSKAhemCAMLILKE-IHNPILINATNSMLQMPLHIAArnGLATVVQALLNRG 979
Cdd:PHA02876  424 SVKTLIDRG-ANVNSKNKDLSTPLHYACKKN---CKLDVIEMlLDNGADVNAINIQNQYPLLIAL--EYHGIVNILLHYG 497


                  .
gi 66392221   980 A 980
Cdd:PHA02876  498 A 498
Ank_2 pfam12796
Ankyrin repeats (3 copies);
243-336 2.82e-12

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 63.60  E-value: 2.82e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221    243 LHVACYTGQEAVANELVNRGANVNQPNHRGYTPLHLAAvSTNGALCLELLVNNgADVNMQSkEGKSPLHMAAIHGRFTRS 322
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAA-KNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIV 77

                           90
                   ....*....|....
gi 66392221    323 QILIQNGGEIDCVD 336
Cdd:pfam12796   78 KLLLEKGADINVKD 91
Ank_2 pfam12796
Ankyrin repeats (3 copies);
790-883 3.11e-12

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 63.60  E-value: 3.11e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221    790 HWAAYHGHEDCLEVLLELKP-CSIQEGNPFTPLHCALINGHSGSAELLLESSVCNSlvnirDAKGRTPLHAAAVAEDVAG 868
Cdd:pfam12796    2 HLAAKNGNLELVKLLLENGAdANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNL-----KDNGRTALHYAARSGHLEI 76

                           90
                   ....*....|....*
gi 66392221    869 LQLVLRQGADIDAVD 883
Cdd:pfam12796   77 VKLLLEKGADINVKD 91
PHA02798 PHA02798
ankyrin-like protein; Provisional
 154-346 7.28e-12

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 69.09  E-value: 7.28e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   154 EMVKLLLNKGANLSASDKKDRQPI-----HWAAYLGHLEVVKLLVSQGSDKSCKDKRGYTPLHAAAASGHV---DVVKYL 225
Cdd:PHA02798   52 DIVKLFINLGANVNGLDNEYSTPLctilsNIKDYKHMLDIVKILIENGADINKKNSDGETPLYCLLSNGYInnlEILLFM 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   226 LRNGAEIDEPNAFGNTALHVACYTG---QEAVANELVNRGANVNQPNHR-GYTPLHL---AAVSTNGALCLELLVNNGAD 298
Cdd:PHA02798  132 IENGADTTLLDKDGFTMLQVYLQSNhhiDIEIIKLLLEKGVDINTHNNKeKYDTLHCyfkYNIDRIDADILKLFVDNGFI 211

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   299 VNMQSKEGKS---------------------------------------PLHMAAIHGRFTRSQILIQNGGEIDCVDRYG 339
Cdd:PHA02798  212 INKENKSHKKkfmeylnsllydnkrfkknildfifsyidinqvdelgfnPLYYSVSHNNRKIFEYLLQLGGDINIITELG 291


                  ....*..
gi 66392221   340 NTPLHVA 346
Cdd:PHA02798  292 NTCLFTA 298
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 213-450 8.40e-12

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 68.48  E-value: 8.40e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   213 AAASGHVDVVKYLLRNGAEIDEPNAFGNTALHVACYTGQEAVANELVNRGA--NVNQPNHRgyTPLHLAAVSTNGALCLE 290
Cdd:PHA02875    9 AILFGELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAipDVKYPDIE--SELHDAVEEGDVKAVEE 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   291 LLVNNGADVNMQSKEGKSPLHMAAIHGRFTRSQILIQNGGEIDCVDRYGNTPLHVAAKYGHELLISTLMTNGADTARQGI 370
Cdd:PHA02875   87 LLDLGKFADDVFYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDC 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   371 HGMFPLHLAVLYGSSDCCRKLLSSGQlysivlsmskehvlsagfdinTPDNFGR----TCLHAAASGGNIECLNLLLSSG 446
Cdd:PHA02875  167 CGCTPLIIAMAKGDIAICKMLLDSGA---------------------NIDYFGKngcvAALCYAIENNKIDIVRLFIKRG 225


                  ....
gi 66392221   447 ADMN 450
Cdd:PHA02875  226 ADCN 229
Ank_2 pfam12796
Ankyrin repeats (3 copies);
719-806 8.40e-12

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 62.06  E-value: 8.40e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221    719 LHRGAVMGREDCLTALLSHNVSVLSRDFQGRSALHLAASCGHADILSNLLSAAdhsqpqDPLTDRHGYTPAHWAAYHGHE 798
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHA------DVNLKDNGRTALHYAARSGHL 74


                   ....*...
gi 66392221    799 DCLEVLLE 806
Cdd:pfam12796   75 EIVKLLLE 82
Ank_2 pfam12796
Ankyrin repeats (3 copies);
526-607 9.92e-12

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 62.06  E-value: 9.92e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221    526 CVEHLLDNGADPCLCNTKGYSAVHYAAAHGNKQNLELLLEMCFntlGDKESNGSiSPLHLAVESGHWECVTVLIESGVCV 605
Cdd:pfam12796   12 LVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHAD---VNLKDNGR-TALHYAARSGHLEIVKLLLEKGADI 87


                   ..
gi 66392221    606 DV 607
Cdd:pfam12796   88 NV 89
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 676-929 1.06e-11

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 68.09  E-value: 1.06e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   676 NVTDAEGQTPLMLAVLGGHTDCVHLLLERGACPDMKDRRGRTALHRGAVMGREDCLTALLSHNV---SVLSRDfqGRSAL 752
Cdd:PHA02875   29 NFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEELLDLGKfadDVFYKD--GMTPL 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   753 HLAASCGHADILSNLLsaADHSQPQDPLTDRhgytpahwaayhghedclevllelkpcsiqegnpFTPLHCALINGHSGS 832
Cdd:PHA02875  107 HLATILKKLDIMKLLI--ARGADPDIPNTDK----------------------------------FSPLHLAVMMGDIKG 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   833 AELLLESSVCnslVNIRDAKGRTPLHAAAVAEDVAGLQLVLRQGADIDAVDHSGRSALM-VAADYGQSGAVALLLHRAkA 911
Cdd:PHA02875  151 IELLIDHKAC---LDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNGCVAALcYAIENNKIDIVRLFIKRG-A 226

                         250       260
                  ....*....|....*....|.
gi 66392221   912 DLSLLDVNKN---TALHLACS 929
Cdd:PHA02875  227 DCNIMFMIEGeecTILDMICN 247
Ank_4 pfam13637
Ankyrin repeats (many copies);
423-476 1.32e-11

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 60.37  E-value: 1.32e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 66392221    423 GRTCLHAAASGGNIECLNLLLSSGADMNKKDKFGRTPLHYAAANGRYQCVVVLV 476
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 180-338 1.44e-11

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 68.74  E-value: 1.44e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   180 AAYLGHLEVVKLLVSQGSDKSCKDKRGYTPLHAAAASGHVDVVKYLLRNGAEIDEPNAFGNTALHVACYTGQEAVANeLV 259
Cdd:PLN03192  532 VASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFR-IL 610

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 66392221   260 NRGANVNQPnHRGYTPLHLAAVSTNGALCLELLvNNGADVNMQSKEGKSPLHMAAIHGRFTRSQILIQNGGEIDCVDRY 338
Cdd:PLN03192  611 YHFASISDP-HAAGDLLCTAAKRNDLTAMKELL-KQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADVDKANTD 687
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 579-860 1.77e-11

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 67.68  E-value: 1.77e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   579 SISPLHLAVESGHWECVTVLIESGVCVDVCDPVGRSVLYLASQRGHSRCVELLLSQSAS-------CLLAE--------- 642
Cdd:PHA02874   35 TTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIDNGVDtsilpipCIEKDmiktildcg 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   643 ------HRSKWGPLHVAAANGHSECLRMLLcsEGGADlVNVTDAEGQTPLMLAVLGGHTDCVHLLLERGACPDMKDRRGR 716
Cdd:PHA02874  115 idvnikDAELKTFLHYAIKKGDLESIKMLF--EYGAD-VNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGE 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   717 TALHRGAVMGREDCLTALLSHNVsvlsrdfqgrsalHLAASCghadilsnllsaadhsqpqdpltdRHGYTPAHWAAYHg 796
Cdd:PHA02874  192 SPLHNAAEYGDYACIKLLIDHGN-------------HIMNKC------------------------KNGFTPLHNAIIH- 233

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 66392221   797 HEDCLEVLLELKPCSIQEGNPFTPLHCALinGHSGSAELLLESSVCNSLVNIRDAKGRTPLHAA 860
Cdd:PHA02874  234 NRSAIELLINNASINDQDIDGSTPLHHAI--NPPCDIDIIDILLYHKADISIKDNKGENPIDTA 295
Ank_4 pfam13637
Ankyrin repeats (many copies);
174-226 1.82e-11

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 59.98  E-value: 1.82e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 66392221    174 RQPIHWAAYLGHLEVVKLLVSQGSDKSCKDKRGYTPLHAAAASGHVDVVKYLL 226
Cdd:pfam13637    2 LTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 342-691 3.65e-11

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 66.83  E-value: 3.65e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   342 PLHVAAKYGHELLISTLMTNGADTARQGIHGMFPLHLAVLYGSSDCCRKLLSSGQLYSIVLSMSK-------------EH 408
Cdd:PHA02878   40 PLHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHIICKEPNKLGMKEMIRSINKCSVFYTLVAikdafnnrnveifKI 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   409 VLSAGFDINTPDNFGRTCLHAAASGGNIECLNLLLSSGADMNKKDK-FGRTPLHYAAANGRYQCVVVLVGAGAEVNERDR 487
Cdd:PHA02878  120 ILTNRYKNIQTIDLVYIDKKSKDDIIEAEITKLLLSYGADINMKDRhKGNTALHYATENKDQRLTELLLSYGANVNIPDK 199

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   488 SGCTPLHysaastafcrtdrpHASTHQNqEDGekesflcVEHLLDNGAdpclcNTKgysavhyaaaHGNKqnlelllemC 567
Cdd:PHA02878  200 TNNSPLH--------------HAVKHYN-KPI-------VHILLENGA-----STD----------ARDK---------C 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   568 FNTlgdkesngsisPLHLAVES-GHWECVTVLIESGVCVDVcdpvgrsvlyLASQRGHSrcvelllsqsascllaehrsk 646
Cdd:PHA02878  234 GNT-----------PLHISVGYcKDYDILKLLLEHGVDVNA----------KSYILGLT--------------------- 271

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*.
gi 66392221   647 wgPLHVAAangHSE-CLRMLLcsEGGADlVNVTDAEGQTPLMLAVL 691
Cdd:PHA02878  272 --ALHSSI---KSErKLKLLL--EYGAD-INSLNSYKLTPLSSAVK 309
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 755-906 5.32e-11

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 66.82  E-value: 5.32e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   755 AASCGHADILSNLLSAAdhsqpQDP-LTDRHGYTPAHWAAYHGHEDCLEVLLElKPCS--IQEGNPFTPLHCALINGHSG 831
Cdd:PLN03192  532 VASTGNAALLEELLKAK-----LDPdIGDSKGRTPLHIAASKGYEDCVLVLLK-HACNvhIRDANGNTALWNAISAKHHK 605

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 66392221   832 SAELLLEssvCNSLVNIRdaKGRTPLHAAAVAEDVAGLQLVLRQGADIDAVDHSGRSALMVAADYGQSGAVALLL 906
Cdd:PLN03192  606 IFRILYH---FASISDPH--AAGDLLCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLI 675
Ank_4 pfam13637
Ankyrin repeats (many copies);
206-259 5.83e-11

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 58.44  E-value: 5.83e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 66392221    206 GYTPLHAAAASGHVDVVKYLLRNGAEIDEPNAFGNTALHVACYTGQEAVANELV 259
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA03095 PHA03095
ankyrin-like protein; Provisional
 18-168 1.40e-10

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 65.05  E-value: 1.40e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221    18 NRNADEVKLFLHKKDEVNALDQERRTPLHaaawlgdVH---------IMDLLISAGANVNAKDHVWLTPLHRAAASRNER 88
Cdd:PHA03095  164 NANVELLRLLIDAGADVYAVDDRFRSLLH-------HHlqsfkprarIVRELIRAGCDPAATDMLGNTPLHSMATGSSCK 236

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221    89 A--VGLLLRKGADVTARDKYWQTPLHIAAANRATRCVETLLPHVSSLNMADRTGRAPLHHAAQSGYQEMVKLLLNKGANL 166
Cdd:PHA03095  237 RslVLPLLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLSLMVRNNNGRAVRAALAKNPSA 316


                  ..
gi 66392221   167 SA 168
Cdd:PHA03095  317 ET 318
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 31-228 2.15e-10

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 64.65  E-value: 2.15e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   31 KDEVNALDQER--RTPLHAAAWLGDVH-IMDLLISAGANVNAKDHVWLTPLHRAAASRNERAVGLLLRKGAD-----VTA 102
Cdd:cd22192    5 LDELHLLQQKRisESPLLLAAKENDVQaIKKLLKCPSCDLFQRGALGETALHVAALYDNLEAAVVLMEAAPElvnepMTS 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221  103 RDKYWQTPLHIAAANRATRCVETLLPHVSSLNMADRTGRA--------------PLHHAAQSGYQEMVKLLLNKGANLSA 168
Cdd:cd22192   85 DLYQGETALHIAVVNQNLNLVRELIARGADVVSPRATGTFfrpgpknliyygehPLSFAACVGNEEIVRLLIEHGADIRA 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221  169 SDkkdrqpihwaaYLGHlEVVKLLVSQGS-DKSCK---------------------DKRGYTPLHAAAASGHVDVVKYLL 226
Cdd:cd22192  165 QD-----------SLGN-TVLHILVLQPNkTFACQmydlilsydkeddlqpldlvpNNQGLTPFKLAAKEGNIVMFQHLV 232


                 ..
gi 66392221  227 RN 228
Cdd:cd22192  233 QK 234
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 144-237 2.72e-10

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 64.53  E-value: 2.72e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   144 LHHAAQSGYQEMVKLLLNKGANLSASDKKDRQPIHWAAYLGHLEVVKLLVSQGSDKSCKDKRGYTPLHAAAASGHVDVVK 223
Cdd:PTZ00322   86 LCQLAASGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQ 165

                          90
                  ....*....|....
gi 66392221   224 YLLRNGAEIDEPNA 237
Cdd:PTZ00322  166 LLSRHSQCHFELGA 179
Ank_4 pfam13637
Ankyrin repeats (many copies);
140-193 5.58e-10

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 55.74  E-value: 5.58e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 66392221    140 GRAPLHHAAQSGYQEMVKLLLNKGANLSASDKKDRQPIHWAAYLGHLEVVKLLV 193
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_2 pfam12796
Ankyrin repeats (3 copies);
890-986 6.19e-10

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 57.05  E-value: 6.19e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221    890 LMVAADYGQSGAVALLLhRAKADLSLLDVNKNTALHLACSKAHEMCAMLILKEIH-NPILINATnsmlqmPLHIAARNGL 968
Cdd:pfam12796    1 LHLAAKNGNLELVKLLL-ENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADvNLKDNGRT------ALHYAARSGH 73

                           90
                   ....*....|....*...
gi 66392221    969 ATVVQALLNRGATVLAVD 986
Cdd:pfam12796   74 LEIVKLLLEKGADINVKD 91
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 428-493 6.91e-10

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 62.99  E-value: 6.91e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 66392221   428 HAAASGGNIEcLNLLLSSGADMNKKDKFGRTPLHYAAANGRYQCVVVLVGAGAEVNERDRSGCTPL 493
Cdd:PTZ00322   88 QLAASGDAVG-ARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPL 152
Ank_2 pfam12796
Ankyrin repeats (3 copies);
549-638 7.67e-10

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 56.66  E-value: 7.67e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221    549 HYAAAHGNKQNLELLLEMCFNtLGDKESNGsISPLHLAVESGHWECVTVLIESgVCVDVCDPvGRSVLYLASQRGHSRCV 628
Cdd:pfam12796    2 HLAAKNGNLELVKLLLENGAD-ANLQDKNG-RTALHLAAKNGHLEIVKLLLEH-ADVNLKDN-GRTALHYAARSGHLEIV 77

                           90
                   ....*....|
gi 66392221    629 ELLLSQSASC 638
Cdd:pfam12796   78 KLLLEKGADI 87
Ank_2 pfam12796
Ankyrin repeats (3 copies);
857-944 8.80e-10

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 56.66  E-value: 8.80e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221    857 LHAAAVAEDVAGLQLVLRQGADIDAVDHSGRSALMVAADYGQSGAVALLLHRAKADlslLDVNKNTALHLACSKAH-EMC 935
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVN---LKDNGRTALHYAARSGHlEIV 77


                   ....*....
gi 66392221    936 AMLILKEIH 944
Cdd:pfam12796   78 KLLLEKGAD 86
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 274-461 1.06e-09

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 62.34  E-value: 1.06e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221  274 TPLHLAAvSTNGALCLE-LLVNNGADVNMQSKEGKSPLHMAAIHGRFTRSQILIQNGGEIDCV----DRY-GNTPLHVAA 347
Cdd:cd22192   19 SPLLLAA-KENDVQAIKkLLKCPSCDLFQRGALGETALHVAALYDNLEAAVVLMEAAPELVNEpmtsDLYqGETALHIAV 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221  348 KYGHELLISTLMTNGADTA---------RQGIHGMFplhlavLYGssdccrkllssgqlysivlsmskEHVLSagfdint 418
Cdd:cd22192   98 VNQNLNLVRELIARGADVVspratgtffRPGPKNLI------YYG-----------------------EHPLS------- 141

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 66392221  419 pdnFgrtclhaAASGGNIECLNLLLSSGADMNKKDKFGRTPLH 461
Cdd:cd22192  142 ---F-------AACVGNEEIVRLLIEHGADIRAQDSLGNTVLH 174
PHA02989 PHA02989
ankyrin repeat protein; Provisional
 90-317 1.27e-09

ankyrin repeat protein; Provisional


Pssm-ID: 222954 [Multi-domain]  Cd Length: 494  Bit Score: 62.07  E-value: 1.27e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221    90 VGLLLRKGADVTARDkYWQTPLHIAAANRA------TRCVETLLPHVSSLNMADRTGRAPLH---HAAQSGYQEMVKLLL 160
Cdd:PHA02989   53 VKLLIDNGADVNYKG-YIETPLCAVLRNREitsnkiKKIVKLLLKFGADINLKTFNGVSPIVcfiYNSNINNCDMLRFLL 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   161 NKGANL-SASDKKDRQPIHwaAYLG----HLEVVKLLVSQGSDK-SCKDKRGYTP----LHAAAASGHVDVVKYLLRNGA 230
Cdd:PHA02989  132 SKGINVnDVKNSRGYNLLH--MYLEsfsvKKDVIKILLSFGVNLfEKTSLYGLTPmniyLRNDIDVISIKVIKYLIKKGV 209

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   231 EIDEPNAFGNTAL------HVACYTGQEAVANELVNRgANVNQPNHRGYTPLHLAAVSTNGALCLELLvNNGADVNMQSK 304
Cdd:PHA02989  210 NIETNNNGSESVLesfldnNKILSKKEFKVLNFILKY-IKINKKDKKGFNPLLISAKVDNYEAFNYLL-KLGDDIYNVSK 287

                         250
                  ....*....|...
gi 66392221   305 EGKSPLHMAAIHG 317
Cdd:PHA02989  288 DGDTVLTYAIKHG 300
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 605-826 1.32e-09

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 62.41  E-value: 1.32e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221    605 VDVCDPVGRSVLYLASQRG-HSRCVELLLSQSasCLLAEHRSKwgpLHVAAANGH---SECLRMLLCSEGGAD---LVNV 677
Cdd:TIGR00870   45 INCPDRLGRSALFVAAIENeNLELTELLLNLS--CRGAVGDTL---LHAISLEYVdavEAILLHLLAAFRKSGpleLAND 119

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221    678 TDA----EGQTPLMLAVLGGHTDCVHLLLERGA-------CPDMKDRRGRTALHRG-------AVMGREDCLTALLSHNV 739
Cdd:TIGR00870  120 QYTseftPGITALHLAAHRQNYEIVKLLLERGAsvparacGDFFVKSQGVDSFYHGesplnaaACLGSPSIVALLSEDPA 199

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221    740 SVLSRDFQGRSALHLAA------------SCGHADILSNLLSAADHSQPQDPLTDRHGYTPAHWAAYHGHEDCLEVLLEL 807
Cdd:TIGR00870  200 DILTADSLGNTLLHLLVmenefkaeyeelSCQMYNFALSLLDKLRDSKELEVILNHQGLTPLKLAAKEGRIVLFRLKLAI 279

                          250       260
                   ....*....|....*....|
gi 66392221    808 KPCSIQ-EGNPFTPLHCALI 826
Cdd:TIGR00870  280 KYKQKKfVAWPNGQQLLSLY 299
PHA03095 PHA03095
ankyrin-like protein; Provisional
 35-152 1.36e-09

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 61.58  E-value: 1.36e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221    35 NALDQERRTPLHAAAWLGDVH--IMDLLISAGANVNAKDHVWLTPLHRAAASRNERAVGLLLRKGADVTARDKYWQTPLH 112
Cdd:PHA03095  216 AATDMLGNTPLHSMATGSSCKrsLVLPLLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLS 295

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 66392221   113 IAAANRATRCVETLLPHVSSLNMADRTgrapLHHAAQSGY 152
Cdd:PHA03095  296 LMVRNNNGRAVRAALAKNPSAETVAAT----LNTASVAGG 331
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 339-564 1.60e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 61.16  E-value: 1.60e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   339 GNTPLHVAAKYGHELLISTLMTNGA--DTARQGIHGmfPLHLAVLYGSSDCCRKLLSSGQLYSIVLSMskehvlsagfDI 416
Cdd:PHA02875   35 GISPIKLAMKFRDSEAIKLLMKHGAipDVKYPDIES--ELHDAVEEGDVKAVEELLDLGKFADDVFYK----------DG 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   417 NTPdnfgrtcLHAAASGGNIECLNLLLSSGAD--MNKKDKFgrTPLHYAAANGRYQCVVVLVGAGAEVNERDRSGCTPLH 494
Cdd:PHA02875  103 MTP-------LHLATILKKLDIMKLLIARGADpdIPNTDKF--SPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLI 173

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 66392221   495 YSAA--STAFCRTdrphasthqnqedgekesflcvehLLDNGADPCLCNTKGYSAVHYAAAHGNKQNLELLL 564
Cdd:PHA02875  174 IAMAkgDIAICKM------------------------LLDSGANIDYFGKNGCVAALCYAIENNKIDIVRLF 221
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 662-883 1.62e-09

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 61.22  E-value: 1.62e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   662 LRMLLcsEGGADLVNVTDAEgQTPLMLAVLGGHT-----DCVHLLLERGACPDMKDRRGRTALHRGAV--MGREDCLTAL 734
Cdd:PHA03100   51 VKILL--DNGADINSSTKNN-STPLHYLSNIKYNltdvkEIVKLLLEYGANVNAPDNNGITPLLYAISkkSNSYSIVEYL 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   735 LSHNVSVLSRDFQGRSALHLAASCGHAD--ILSNLLSaadhsqpqdpltdrHGYtpahwaaYHGHEDCLEVLLELK-PCS 811
Cdd:PHA03100  128 LDNGANVNIKNSDGENLLHLYLESNKIDlkILKLLID--------------KGV-------DINAKNRVNYLLSYGvPIN 186

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 66392221   812 IQEGNPFTPLHCALINGHSGSAELLLESSvCNslVNIRDAKGRTPLHAAAVAEDVAGLQLVLRQGADIDAVD 883
Cdd:PHA03100  187 IKDVYGFTPLHYAVYNNNPEFVKYLLDLG-AN--PNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSIKTII 255
PHA02798 PHA02798
ankyrin-like protein; Provisional
 54-313 2.31e-09

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 61.00  E-value: 2.31e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221    54 VHIMDLLISAGANVNAKDHVWLTPLhraaasrneravglllrkgADVTARDKYWQTPLHIaaanratrcVETLLPHVSSL 133
Cdd:PHA02798   51 TDIVKLFINLGANVNGLDNEYSTPL-------------------CTILSNIKDYKHMLDI---------VKILIENGADI 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   134 NMADRTGRAPLHHAAQSGY---QEMVKLLLNKGANLSASDKKDRQPIHWAAYLGH---LEVVKLLVSQGSD-KSCKDKRG 206
Cdd:PHA02798  103 NKKNSDGETPLYCLLSNGYinnLEILLFMIENGADTTLLDKDGFTMLQVYLQSNHhidIEIIKLLLEKGVDiNTHNNKEK 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   207 YTPLHAAAASG----HVDVVKYLLRNGAEIDEPNAFGNTALhvACYTGQEAVANELVNRGA--------NVNQPNHRGYT 274
Cdd:PHA02798  183 YDTLHCYFKYNidriDADILKLFVDNGFIINKENKSHKKKF--MEYLNSLLYDNKRFKKNIldfifsyiDINQVDELGFN 260

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 66392221   275 PLHLaAVSTNGALCLELLVNNGADVNMQSKEGKSPLHMA 313
Cdd:PHA02798  261 PLYY-SVSHNNRKIFEYLLQLGGDINIITELGNTCLFTA 298
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 337-494 2.57e-09

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 61.18  E-value: 2.57e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221  337 RYGNTPLHVAAKYGHELLISTLMT-NGADTARQGIHGMFPLHLAVLYGSSDCCRKLLSSgqlysiVLSMSKEHVLSAGFD 415
Cdd:cd22192   15 RISESPLLLAAKENDVQAIKKLLKcPSCDLFQRGALGETALHVAALYDNLEAAVVLMEA------APELVNEPMTSDLYQ 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221  416 intpdnfGRTCLHAAASGGNIECLNLLLSSGADM------------NKKDK--FGRTPLHYAAANGRYQCVVVLVGAGAE 481
Cdd:cd22192   89 -------GETALHIAVVNQNLNLVRELIARGADVvspratgtffrpGPKNLiyYGEHPLSFAACVGNEEIVRLLIEHGAD 161

                        170
                 ....*....|...
gi 66392221  482 VNERDRSGCTPLH 494
Cdd:cd22192  162 IRAQDSLGNTVLH 174
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 429-606 3.40e-09

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 61.04  E-value: 3.40e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   429 AAASGGNIECLNLLLSSGADMNKKDKFGRTPLHYAAANGRYQCVVVLVGAGAEVNERDRSGCTPLHYSAAST-------- 500
Cdd:PLN03192  531 TVASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKhhkifril 610

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   501 -AFCRTDRPHAsthqnqedgekesflcvehlldnGADpCLCntkgysavhYAAAHGNKQNLELLLEMCFNTlgDKESNGS 579
Cdd:PLN03192  611 yHFASISDPHA-----------------------AGD-LLC---------TAAKRNDLTAMKELLKQGLNV--DSEDHQG 655

                         170       180
                  ....*....|....*....|....*..
gi 66392221   580 ISPLHLAVESGHWECVTVLIESGVCVD 606
Cdd:PLN03192  656 ATALQVAMAEDHVDMVRLLIMNGADVD 682
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 66-284 3.88e-09

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 60.87  E-value: 3.88e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221     66 NVNAKDHVWLTPLHRAAA-SRNERAVGLLLRKGADVTARDkywqTPLHiAAANRATRCVETLLPHV-------SSLNMA- 136
Cdd:TIGR00870   44 NINCPDRLGRSALFVAAIeNENLELTELLLNLSCRGAVGD----TLLH-AISLEYVDAVEAILLHLlaafrksGPLELAn 118

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221    137 DRT------GRAPLHHAAQSGYQEMVKLLLNKGANLSA---------SDKKD-----RQPIHWAAYLGHLEVVKLLVSQG 196
Cdd:TIGR00870  119 DQYtseftpGITALHLAAHRQNYEIVKLLLERGASVPAracgdffvkSQGVDsfyhgESPLNAAACLGSPSIVALLSEDP 198

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221    197 SDKSCKDKRGYTPLHAAAasghvdvvkyllrngaeIDEPNAFGNTALHVACYtgqeavaNELVNRGANVNQ-------PN 269
Cdd:TIGR00870  199 ADILTADSLGNTLLHLLV-----------------MENEFKAEYEELSCQMY-------NFALSLLDKLRDskeleviLN 254

                          250
                   ....*....|....*
gi 66392221    270 HRGYTPLHLAAVSTN 284
Cdd:TIGR00870  255 HQGLTPLKLAAKEGR 269
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 654-737 4.74e-09

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 60.30  E-value: 4.74e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   654 AANGHSECLRMLLcsEGGADlVNVTDAEGQTPLMLAVLGGHTDCVHLLLERGACPDMKDRRGRTALHRGAVMGREDCLTA 733
Cdd:PTZ00322   90 AASGDAVGARILL--TGGAD-PNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQL 166


                  ....
gi 66392221   734 LLSH 737
Cdd:PTZ00322  167 LSRH 170
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 582-893 1.24e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 58.74  E-value: 1.24e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   582 PLHLAVESGHWECVTVLIESGVCVDVCDPVGRSVLYLASQRGHSRCVELLLSQSASCLLAEHRSKwgpLHVAAANGHSEC 661
Cdd:PHA02878   40 PLHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHIICKEPNKLGMKEMIRSINKCSVFYTLVA---IKDAFNNRNVEI 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   662 LRMLLCS----EGGADLVNVTDAEGQTPLmlavlggHTDCVHLLLERGACPDMKDR-RGRTALHRGAVMGREDCLTALLS 736
Cdd:PHA02878  117 FKIILTNryknIQTIDLVYIDKKSKDDII-------EAEITKLLLSYGADINMKDRhKGNTALHYATENKDQRLTELLLS 189

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   737 HNVSVLSRDFQGRSALHLAASCGHADILSNLL---SAADHSqpqdpltDRHGYTPAHWAAyhGHEDCLEVLlelkpcsiq 813
Cdd:PHA02878  190 YGANVNIPDKTNNSPLHHAVKHYNKPIVHILLengASTDAR-------DKCGNTPLHISV--GYCKDYDIL--------- 251

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   814 egnpftplhcalinghsgsaELLLESSVCnslVNIRDA-KGRTPLHAAAVAEDVagLQLVLRQGADIDAVDHSGRSALMV 892
Cdd:PHA02878  252 --------------------KLLLEHGVD---VNAKSYiLGLTALHSSIKSERK--LKLLLEYGADINSLNSYKLTPLSS 306


                  .
gi 66392221   893 A 893
Cdd:PHA02878  307 A 307
TRPV cd21882
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily ...
 139-284 1.37e-08

Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily (TRPV), named after the vanilloid receptor 1 (TRPV1), consists of six members: four thermo-sensing channels (TRPV1, TRPV2, TRPV3, and TRPV4) and two Ca2+ selective channels (TRPV5 and TRPV6). The calcium-selective channels TRPV5 and TRPV6 can be heterotetramers and are important for general Ca2+ homeostasis. All four channels within the TRPV1-4 group show temperature-invoked currents when expressed in heterologous cell systems, ranging from activation at ~25C for TRPV4 to ~52C for TRPV2. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains. The TRP family consists of membrane proteins that function as ion channels that communicate between the cell and its environment, by a vast array of physical or chemical stimuli, including radiation (in the form of temperature, infrared ,or light) and pressure (osmotic or mechanical). TRP channels are formed by a tetrameric complex of channel subunits. Based on sequence identity, the mammalian TRP channel family is classified into six subfamilies, with significant sequence similarity within the transmembrane domains, but very low similarity in their N- and C-terminal cytoplasmic regions. The six subfamilies are named based on their first member: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPA (ankyrin), TRPML (mucolipin), and TRPP (polycystic).


Pssm-ID: 411975 [Multi-domain]  Cd Length: 600  Bit Score: 58.74  E-value: 1.37e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221  139 TGRAPLHHAA---QSGYQEMVKLLLNKG---------ANLSASDK--KDRQPIHWAAYLGHLEVVKLLVSQGSD---KSC 201
Cdd:cd21882   25 TGKTCLHKAAlnlNDGVNEAIMLLLEAApdsgnpkelVNAPCTDEfyQGQTALHIAIENRNLNLVRLLVENGADvsaRAT 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221  202 KD--KR--------GYTPLHAAAASGHVDVVKYLLRNGAEIDEPNA---FGNTALHVACYTGQEAVA---------NELV 259
Cdd:cd21882  105 GRffRKspgnlfyfGELPLSLAACTNQEEIVRLLLENGAQPAALEAqdsLGNTVLHALVLQADNTPEnsafvcqmyNLLL 184

                        170       180       190
                 ....*....|....*....|....*....|..
gi 66392221  260 NRGANVNQ-------PNHRGYTPLHLAAVSTN 284
Cdd:cd21882  185 SYGAHLDPtqqleeiPNHQGLTPLKLAAVEGK 216
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 7-152 1.39e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 58.74  E-value: 1.39e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221     7 SDQPPLVQAIFNRNADEVKLFLHKKDEVNALDQERRTPLHAAAWLGDVHIMDLLISAGANVNAKDHVWLTPLHRAAAS-R 85
Cdd:PHA02878  167 KGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHISVGYcK 246

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 66392221    86 NERAVGLLLRKGADVTARDKYWQ-TPLHIAAanRATRCVETLLPHVSSLNMADRTGRAPLHHAAQSGY 152
Cdd:PHA02878  247 DYDILKLLLEHGVDVNAKSYILGlTALHSSI--KSERKLKLLLEYGADINSLNSYKLTPLSSAVKQYL 312
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 833-999 1.68e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 58.54  E-value: 1.68e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   833 AELLLESSVCnslVNIRDAKGRTPLHAAAVAEDVAGLQLVLRQGADIDAVDHSGRSALMVAADYGQSGAV-ALLLHRA-- 909
Cdd:PHA02876  161 AEMLLEGGAD---VNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIkAIIDNRSni 237

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   910 -KADLSLLDVNKNTALHLAcskahemcamLILKEihNPILINATNSMLQMPLHIAARN-GLATVVQALLNRGATVLAVDE 987
Cdd:PHA02876  238 nKNDLSLLKAIRNEDLETS----------LLLYD--AGFSVNSIDDCKNTPLHHASQApSLSRLVPKLLERGADVNAKNI 305

                         170
                  ....*....|..
gi 66392221   988 EGHTPALACASN 999
Cdd:PHA02876  306 KGETPLYLMAKN 317
Ank_2 pfam12796
Ankyrin repeats (3 copies);
821-917 2.20e-08

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 52.43  E-value: 2.20e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221    821 LHCALINGHSGSAELLLEssvCNSLVNIRDAKGRTPLHAAAVAEDVAGLQLVLRQgADIDAVDHsGRSALMVAADYGQSG 900
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLE---NGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDN-GRTALHYAARSGHLE 75

                           90
                   ....*....|....*..
gi 66392221    901 AVALLLHRaKADLSLLD 917
Cdd:pfam12796   76 IVKLLLEK-GADINVKD 91
Ank_4 pfam13637
Ankyrin repeats (many copies);
74-127 3.58e-08

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 50.74  E-value: 3.58e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 66392221     74 WLTPLHRAAASRNERAVGLLLRKGADVTARDKYWQTPLHIAAANRATRCVETLL 127
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 183-374 3.69e-08

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 57.57  E-value: 3.69e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   183 LGHLEVVKLLVSQGSDKSckDKRGYTPLHAAAASGHVDVVKYLLRNGAEIDEPNAFGNTALHVACYTGQEAVANELVNRG 262
Cdd:PLN03192  504 LHDLNVGDLLGDNGGEHD--DPNMASNLLTVASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHA 581

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   263 ANVNQPNHRGYTPLhLAAVSTNGALCLELLVNNGADVNMQSkeGKSPLHMAAIHGRFTRSQILIQNGGEIDCVDRYGNTP 342
Cdd:PLN03192  582 CNVHIRDANGNTAL-WNAISAKHHKIFRILYHFASISDPHA--AGDLLCTAAKRNDLTAMKELLKQGLNVDSEDHQGATA 658

                         170       180       190
                  ....*....|....*....|....*....|..
gi 66392221   343 LHVAAKYGHELLISTLMTNGADTARQGIHGMF 374
Cdd:PLN03192  659 LQVAMAEDHVDMVRLLIMNGADVDKANTDDDF 690
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 72-176 3.78e-08

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 57.60  E-value: 3.78e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221    72 HVWLTPLHRAAASRNERAVGLLLRKGADVTARDKYWQTPLHIAAANRATRCVETLLPHVSSLNMADRTGRAPLHHAAQSG 151
Cdd:PTZ00322   80 HMLTVELCQLAASGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENG 159

                          90       100       110
                  ....*....|....*....|....*....|..
gi 66392221   152 YQEMVKLLL-------NKGANlSASDKKDRQP 176
Cdd:PTZ00322  160 FREVVQLLSrhsqchfELGAN-AKPDSFTGKP 190
Ank_4 pfam13637
Ankyrin repeats (many copies);
647-702 5.19e-08

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 50.35  E-value: 5.19e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 66392221    647 WGPLHVAAANGHSECLRMLLCSegGADlVNVTDAEGQTPLMLAVLGGHTDCVHLLL 702
Cdd:pfam13637    2 LTALHAAAASGHLELLRLLLEK--GAD-INAVDGNGETALHFAASNGNVEVLKLLL 54
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 551-706 5.74e-08

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 57.19  E-value: 5.74e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   551 AAAHGNKQNLELLLEMCFNT-LGDkeSNGSiSPLHLAVESGHWECVTVLIESGVCVDVCDPVGRSVLYLASQRGHSRCVE 629
Cdd:PLN03192  532 VASTGNAALLEELLKAKLDPdIGD--SKGR-TPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFR 608

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 66392221   630 LLLSQSAsclLAEHRSKWGPLHVAAANGHSECLRMLLcsEGGADlVNVTDAEGQTPLMLAVLGGHTDCVHLLLERGA 706
Cdd:PLN03192  609 ILYHFAS---ISDPHAAGDLLCTAAKRNDLTAMKELL--KQGLN-VDSEDHQGATALQVAMAEDHVDMVRLLIMNGA 679
PHA02716 PHA02716
CPXV016; CPX019; EVM010; Provisional
 289-493 7.22e-08

CPXV016; CPX019; EVM010; Provisional


Pssm-ID: 165089 [Multi-domain]  Cd Length: 764  Bit Score: 56.84  E-value: 7.22e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   289 LELLVNNGADVNMQSKEGKSPLHMAAIHGRFTRSQI--LIQNGGEID--CVDryGNTPlhvaakyghellISTLMTNGAD 364
Cdd:PHA02716  195 LEWLCNNGVNVNLQNNHLITPLHTYLITGNVCASVIkkIIELGGDMDmkCVN--GMSP------------IMTYIINIDN 260

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   365 TARQGIHgmfplhlavLYGSSDCCRKLLSSGQLYSIVLSMSK-------EHVLSAGFDINTPDNFGRTCLHAAASGGNI- 436
Cdd:PHA02716  261 INPEITN---------IYIESLDGNKVKNIPMILHSYITLARnidisvvYSFLQPGVKLHYKDSAGRTCLHQYILRHNIs 331

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 66392221   437 -ECLNLLLSSGADMNKKDKFGRTPLHYAAA--------------NGRYQCVVVLVGAGAEVNERDRSGCTPL 493
Cdd:PHA02716  332 tDIIKLLHEYGNDLNEPDNIGNTVLHTYLSmlsvvnildpetdnDIRLDVIQCLISLGADITAVNCLGYTPL 403
PHA02859 PHA02859
ankyrin repeat protein; Provisional
 143-278 8.56e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165195 [Multi-domain]  Cd Length: 209  Bit Score: 54.05  E-value: 8.56e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   143 PLHHAAQSGY--QEMVKLLLNKGANLSASDKKDR-QPIHWaaYLGH-----LEVVKLLVSQGSDKSCKDKRGYTPLHA-- 212
Cdd:PHA02859   54 PIFSCLEKDKvnVEILKFLIENGADVNFKTRDNNlSALHH--YLSFnknvePEILKILIDSGSSITEEDEDGKNLLHMym 131

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 66392221   213 AAASGHVDVVKYLLRNGAEIDEPNAFGNTALHV-ACYTGQEAVANELVNRGANVNQPNHRGYTPLHL 278
Cdd:PHA02859  132 CNFNVRINVIKLLIDSGVSFLNKDFDNNNILYSyILFHSDKKIFDFLTSLGIDINETNKSGYNCYDL 198
PHA02946 PHA02946
ankyin-like protein; Provisional
 53-278 1.19e-07

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 55.45  E-value: 1.19e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221    53 DVHIMDLLISAGANVNAKDHVWLTPLHRAAASRNERAVGLLLRKGADVTARDKYWQTPLHIAAA--NRATRCVETLLPHV 130
Cdd:PHA02946   51 DERFVEELLHRGYSPNETDDDGNYPLHIASKINNNRIVAMLLTHGADPNACDKQHKTPLYYLSGtdDEVIERINLLVQYG 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   131 SSLNMA-DRTGRAPLhhaaqsgyqemvklllnkganLSASDKKDRqpihwaaylghleVVKLLVSQGSDKSCKDKRGYTP 209
Cdd:PHA02946  131 AKINNSvDEEGCGPL---------------------LACTDPSER-------------VFKKIMSIGFEARIVDKFGKNH 176

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 66392221   210 LHAAAASGH--VDVVKYLLRNGAEIDEPNAFGNTALHVACytgQEAVAN----ELVNRGANVNQPNHRGYTPLHL 278
Cdd:PHA02946  177 IHRHLMSDNpkASTISWMMKLGISPSKPDHDGNTPLHIVC---SKTVKNvdiiNLLLPSTDVNKQNKFGDSPLTL 248
Ank_4 pfam13637
Ankyrin repeats (many copies);
785-837 1.80e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 48.81  E-value: 1.80e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 66392221    785 GYTPAHWAAYHGHEDCLEVLLELK-PCSIQEGNPFTPLHCALINGHSGSAELLL 837
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGaDINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 834-999 1.89e-07

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 54.67  E-value: 1.89e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   834 ELLLESSVCnslVNIRDAKGRTPLHAAAVAEDVAG-----LQLVLRQGADIDAVDHSGRSALMVAADY--GQSGAVALLL 906
Cdd:PHA03100   52 KILLDNGAD---INSSTKNNSTPLHYLSNIKYNLTdvkeiVKLLLEYGANVNAPDNNGITPLLYAISKksNSYSIVEYLL 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   907 HRAkADLSLLDVNKNTALHLA---CSKAHEMCAMLILKEIH------------NPILINATNSMLQMPLHIAARNGLATV 971
Cdd:PHA03100  129 DNG-ANVNIKNSDGENLLHLYlesNKIDLKILKLLIDKGVDinaknrvnyllsYGVPINIKDVYGFTPLHYAVYNNNPEF 207

                         170       180
                  ....*....|....*....|....*....
gi 66392221   972 VQALLNRGATVLAVDEEGHTPA-LACASN 999
Cdd:PHA03100  208 VKYLLDLGANPNLVNKYGDTPLhIAILNN 236
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 396-719 2.58e-07

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 54.50  E-value: 2.58e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   396 QLYSIVLSMSKEHVLSAGFDINTPDNF--GRTC-----LHAAASGGNIECLNLLLSSGADMNKKDKFGRTPLHYAAANGR 468
Cdd:PHA02878    3 KLYKSMYTDNYETILKYIEYIDHTENYstSASLipfipLHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHIICKEPN 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   469 YQCVVVLVgagAEVNERDRSgctpLHYSAASTAFCRTDRPHA-STHQNQEDGEKES---FLCvEHLLDNGADPCLcntkg 544
Cdd:PHA02878   83 KLGMKEMI---RSINKCSVF----YTLVAIKDAFNNRNVEIFkIILTNRYKNIQTIdlvYID-KKSKDDIIEAEI----- 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   545 ysaVHYAAAHGNKQNLelllemcfntlgdKESNGSISPLHLAVESGHWECVTVLIESGVCVDVCDPVGRSVLYLASQRGH 624
Cdd:PHA02878  150 ---TKLLLSYGADINM-------------KDRHKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYN 213

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   625 SRCVELLLSQSAScllAEHRSKWG--PLHVAAANGHS-ECLRMLLcsEGGADLVNVTDAEGQTPLMLAVlgGHTDCVHLL 701
Cdd:PHA02878  214 KPIVHILLENGAS---TDARDKCGntPLHISVGYCKDyDILKLLL--EHGVDVNAKSYILGLTALHSSI--KSERKLKLL 286

                         330
                  ....*....|....*...
gi 66392221   702 LERGACPDMKDRRGRTAL 719
Cdd:PHA02878  287 LEYGADINSLNSYKLTPL 304
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 581-720 2.60e-07

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 54.63  E-value: 2.60e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221  581 SPLHLAVESGHWECVTVLIESGVCvDVCD--PVGRSVLYLASQRGH-------SRCVELLLSQSASCLLAEHRSkwgPLH 651
Cdd:cd22192   19 SPLLLAAKENDVQAIKKLLKCPSC-DLFQrgALGETALHVAALYDNleaavvlMEAAPELVNEPMTSDLYQGET---ALH 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221  652 VAAANGHSECLRMLLcsEGGADLVN--VTDA-----------EGQTPLMLAVLGGHTDCVHLLLERGACPDMKDRRGRTA 718
Cdd:cd22192   95 IAVVNQNLNLVRELI--ARGADVVSprATGTffrpgpknliyYGEHPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTV 172


                 ..
gi 66392221  719 LH 720
Cdd:cd22192  173 LH 174
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 787-978 3.06e-07

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 54.63  E-value: 3.06e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221  787 TPAHWAAYHGHEDCLEVLLELKPCSIQEGNPF--TPLHCALINGHSGSAELLLESSvcNSLVNIRDA----KGRTPLHAA 860
Cdd:cd22192   19 SPLLLAAKENDVQAIKKLLKCPSCDLFQRGALgeTALHVAALYDNLEAAVVLMEAA--PELVNEPMTsdlyQGETALHIA 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221  861 AVAEDVAGLQLVLRQGADI--------------DAVDHSGRSALMVAADYGQSGAVALLLHRAkADLSLLDVNKNTALHL 926
Cdd:cd22192   97 VVNQNLNLVRELIARGADVvspratgtffrpgpKNLIYYGEHPLSFAACVGNEEIVRLLIEHG-ADIRAQDSLGNTVLHI 175

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 66392221  927 ACSKAHE--MCAM--LIL---KEIHNPILINATNSMLQMPLHIAARNGLATVVQALLNR 978
Cdd:cd22192  176 LVLQPNKtfACQMydLILsydKEDDLQPLDLVPNNQGLTPFKLAAKEGNIVMFQHLVQK 234
PHA02946 PHA02946
ankyin-like protein; Provisional
 325-493 3.82e-07

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 53.90  E-value: 3.82e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   325 LIQNGGEIDCVDRYGNTPLHVAAKYGHELLISTLMTNGADTARQGIHGMFPLH--------------LAVLYGS------ 384
Cdd:PHA02946   58 LLHRGYSPNETDDDGNYPLHIASKINNNRIVAMLLTHGADPNACDKQHKTPLYylsgtddevierinLLVQYGAkinnsv 137

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   385 -SDCCRKLLSSGQLYSIVLsmskEHVLSAGFDINTPDNFGRTCLHAAASGGN--IECLNLLLSSGADMNKKDKFGRTPLH 461
Cdd:PHA02946  138 dEEGCGPLLACTDPSERVF----KKIMSIGFEARIVDKFGKNHIHRHLMSDNpkASTISWMMKLGISPSKPDHDGNTPLH 213

                         170       180       190
                  ....*....|....*....|....*....|...
gi 66392221   462 YAAANGRYQC-VVVLVGAGAEVNERDRSGCTPL 493
Cdd:PHA02946  214 IVCSKTVKNVdIINLLLPSTDVNKQNKFGDSPL 246
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 189-258 3.83e-07

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 54.13  E-value: 3.83e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   189 VKLLVSQGSDKSCKDKRGYTPLHAAAASGHVDVVKYLLRNGAEIDEPNAFGNTALHVACYTGQEAVANEL 258
Cdd:PTZ00322   98 ARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLL 167
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 277-359 4.14e-07

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 54.13  E-value: 4.14e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   277 HLAAvsTNGALCLELLVNNGADVNMQSKEGKSPLHMAAIHGRFTRSQILIQNGGEIDCVDRYGNTPLHVAAKYGHELLIS 356
Cdd:PTZ00322   88 QLAA--SGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQ 165


                  ...
gi 66392221   357 TLM 359
Cdd:PTZ00322  166 LLS 168
PHA02798 PHA02798
ankyrin-like protein; Provisional
 186-450 5.15e-07

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 53.69  E-value: 5.15e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   186 LEVVKLLVSQGSDKSCKDKRGYTPLHAAAAS-----GHVDVVKYLLRNGAEIDEPNAFGNTALHvaCYTGQEAVANE--- 257
Cdd:PHA02798   51 TDIVKLFINLGANVNGLDNEYSTPLCTILSNikdykHMLDIVKILIENGADINKKNSDGETPLY--CLLSNGYINNLeil 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   258 --LVNRGANVNQPNHRGYTPLHLAAVSTNGAL--CLELLVNNGADVNMQS-KEGKSPLHmAAIHGRFTR-----SQILIQ 327
Cdd:PHA02798  129 lfMIENGADTTLLDKDGFTMLQVYLQSNHHIDieIIKLLLEKGVDINTHNnKEKYDTLH-CYFKYNIDRidadiLKLFVD 207

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   328 NGGEIDCVDRYGNTPLhvaakygHELLISTLMTNGA-------------DTARQGIHGMFPLHLAVLYGSSDCCrkllss 394
Cdd:PHA02798  208 NGFIINKENKSHKKKF-------MEYLNSLLYDNKRfkknildfifsyiDINQVDELGFNPLYYSVSHNNRKIF------ 274

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 66392221   395 gqlysivlsmskEHVLSAGFDINTPDNFGRTCLHAAASGGNIECLNLLLSSGADMN 450
Cdd:PHA02798  275 ------------EYLLQLGGDINIITELGNTCLFTAFENESKFIFNSILNKKPNKN 318
Ank_4 pfam13637
Ankyrin repeats (many copies);
41-94 5.20e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 47.27  E-value: 5.20e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 66392221     41 RRTPLHAAAWLGDVHIMDLLISAGANVNAKDHVWLTPLHRAAASRNERAVGLLL 94
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_4 pfam13637
Ankyrin repeats (many copies);
456-498 6.14e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 47.27  E-value: 6.14e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 66392221    456 GRTPLHYAAANGRYQCVVVLVGAGAEVNERDRSGCTPLHYSAA 498
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAAS 43
TRPV3 cd22194
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a ...
 230-350 6.55e-07

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a temperature-sensitive Transient Receptor Potential (TRP) ion channel that is activated by warm temperatures, synthetic small-molecule chemicals, and natural compounds from plants. TRPV3 function is regulated by physiological factors such as extracellular divalent cations and acidic pH, intracellular adenosine triphosphate, membrane voltage, and arachidonic acid. It is expressed in both neuronal and non-neuronal tissues including epidermal keratinocytes, epithelial cells in the gut, endothelial cells in blood vessels, and neurons in dorsal root ganglia and CNS. TRPV3 null mice have abnormal hair morphogenesis and compromised skin barrier function. It may play roles in inflammatory skin disorders, such as itch and pain sensation. TRPV3 is also expressed by many neuronal and non-neuronal tissues, showing that TRPV3 might play roles in other unknown cellular and physiological functions. TRPV3 belongs to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411978 [Multi-domain]  Cd Length: 680  Bit Score: 53.61  E-value: 6.55e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221  230 AEIDEPNAFGNTALHVACYTGQEAVANELVNRGANVN--------QPNHR------GYTPLHLAAVsTNGALCLELLVNN 295
Cdd:cd22194  132 AEYTEEAYEGQTALNIAIERRQGDIVKLLIAKGADVNahakgvffNPKYKhegfyfGETPLALAAC-TNQPEIVQLLMEK 210

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 66392221  296 GAD-VNMQSKEGKSPLH---MAA----IHGRFTR---SQILIQNGGE-IDCV-DRYGNTPLHVAAKYG 350
Cdd:cd22194  211 ESTdITSQDSRGNTVLHalvTVAedskTQNDFVKrmyDMILLKSENKnLETIrNNEGLTPLQLAAKMG 278
Ank_4 pfam13637
Ankyrin repeats (many copies);
684-735 7.25e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 46.88  E-value: 7.25e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 66392221    684 TPLMLAVLGGHTDCVHLLLERGACPDMKDRRGRTALHRGAVMGREDCLTALL 735
Cdd:pfam13637    3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 842-1006 7.41e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 53.04  E-value: 7.41e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   842 CNSLVNIRDAKGRTPLHAAAVAEDVAGLQLVLRQGADIDAVDHSGRSALMVAADYGQSGAVALLLHRAkADLSLLDVNKN 921
Cdd:PHA02874  113 CGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKG-AYANVKDNNGE 191

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   922 TALHLACSKAHEMCAMLILKEIHNpILINATNSMlqMPLHIAARNGlATVVQALLNrGATVLAVDEEGHTP---ALACAS 998
Cdd:PHA02874  192 SPLHNAAEYGDYACIKLLIDHGNH-IMNKCKNGF--TPLHNAIIHN-RSAIELLIN-NASINDQDIDGSTPlhhAINPPC 266


                  ....*...
gi 66392221   999 NKAVADCL 1006
Cdd:PHA02874  267 DIDIIDIL 274
PHA02798 PHA02798
ankyrin-like protein; Provisional
 323-488 7.86e-07

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 52.91  E-value: 7.86e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   323 QILIQNGGEIDCVDRYGNTPLHVA----AKYGHEL-LISTLMTNGADTARQGIHGMFPLhlavlygssdCCrkLLSSGQL 397
Cdd:PHA02798   55 KLFINLGANVNGLDNEYSTPLCTIlsniKDYKHMLdIVKILIENGADINKKNSDGETPL----------YC--LLSNGYI 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   398 YS--IVLSMskehvLSAGFDINTPDNFGRTCLHAAASGGN---IECLNLLLSSGADMNK-KDKFGRTPLH-YAAANgrYQ 470
Cdd:PHA02798  123 NNleILLFM-----IENGADTTLLDKDGFTMLQVYLQSNHhidIEIIKLLLEKGVDINThNNKEKYDTLHcYFKYN--ID 195

                         170       180
                  ....*....|....*....|...
gi 66392221   471 CVVV-----LVGAGAEVNERDRS 488
Cdd:PHA02798  196 RIDAdilklFVDNGFIINKENKS 218
Ank_4 pfam13637
Ankyrin repeats (many copies);
308-358 8.57e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 46.88  E-value: 8.57e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 66392221    308 SPLHMAAIHGRFTRSQILIQNGGEIDCVDRYGNTPLHVAAKYGHELLISTL 358
Cdd:pfam13637    3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLL 53
Ank_5 pfam13857
Ankyrin repeats (many copies);
447-495 9.01e-07

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 46.96  E-value: 9.01e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 66392221    447 ADMNKKDKFGRTPLHYAAANGRYQCVVVLVGAGAEVNERDRSGCTPLHY 495
Cdd:pfam13857    7 IDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDL 55
TRPV cd21882
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily ...
 650-806 1.10e-06

Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily (TRPV), named after the vanilloid receptor 1 (TRPV1), consists of six members: four thermo-sensing channels (TRPV1, TRPV2, TRPV3, and TRPV4) and two Ca2+ selective channels (TRPV5 and TRPV6). The calcium-selective channels TRPV5 and TRPV6 can be heterotetramers and are important for general Ca2+ homeostasis. All four channels within the TRPV1-4 group show temperature-invoked currents when expressed in heterologous cell systems, ranging from activation at ~25C for TRPV4 to ~52C for TRPV2. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains. The TRP family consists of membrane proteins that function as ion channels that communicate between the cell and its environment, by a vast array of physical or chemical stimuli, including radiation (in the form of temperature, infrared ,or light) and pressure (osmotic or mechanical). TRP channels are formed by a tetrameric complex of channel subunits. Based on sequence identity, the mammalian TRP channel family is classified into six subfamilies, with significant sequence similarity within the transmembrane domains, but very low similarity in their N- and C-terminal cytoplasmic regions. The six subfamilies are named based on their first member: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPA (ankyrin), TRPML (mucolipin), and TRPP (polycystic).


Pssm-ID: 411975 [Multi-domain]  Cd Length: 600  Bit Score: 52.57  E-value: 1.10e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221  650 LHVAAAN---GHSECLRMLL----CSEGGADLVN--VTDA--EGQTPLMLAVLGGHTDCVHLLLERG------ACPDMKD 712
Cdd:cd21882   30 LHKAALNlndGVNEAIMLLLeaapDSGNPKELVNapCTDEfyQGQTALHIAIENRNLNLVRLLVENGadvsarATGRFFR 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221  713 RRGRTALHRG-------AVMGREDCLTALLSHN---VSVLSRDFQGRSALHL------------AASCGHADILSNLLSA 770
Cdd:cd21882  110 KSPGNLFYFGelplslaACTNQEEIVRLLLENGaqpAALEAQDSLGNTVLHAlvlqadntpensAFVCQMYNLLLSYGAH 189

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 66392221  771 ADHSQPQDPLTDRHGYTPAHWAAYHGHEDCLEVLLE 806
Cdd:cd21882  190 LDPTQQLEEIPNHQGLTPLKLAAVEGKIVMFQHILQ 225
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 52-129 1.29e-06

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 52.59  E-value: 1.29e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 66392221    52 GDVHIMDLLISAGANVNAKDHVWLTPLHRAAASRNERAVGLLLRKGADVTARDKYWQTPLHIAAANRATRCVETLLPH 129
Cdd:PTZ00322   93 GDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRH 170
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 606-707 1.49e-06

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 52.21  E-value: 1.49e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   606 DVCDPVGRSVLYLA----SQRGHSRCVELLLSQSASCLLAEHRSKwGPLHVAAANGHSECLRMLLcsEGGADlVNVTDAE 681
Cdd:PTZ00322   72 EVIDPVVAHMLTVElcqlAASGDAVGARILLTGGADPNCRDYDGR-TPLHIACANGHVQVVRVLL--EFGAD-PTLLDKD 147

                          90       100
                  ....*....|....*....|....*.
gi 66392221   682 GQTPLMLAVLGGHTDCVHLLLERGAC 707
Cdd:PTZ00322  148 GKTPLELAEENGFREVVQLLSRHSQC 173
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 816-987 1.55e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 51.97  E-value: 1.55e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   816 NPFTPLHCALINgHSGSAEL--LLESSVCNslVNIRDAKGRTPLHAAA--VAEDVAGLQLVLRQGADIDAVDHsgrsalm 891
Cdd:PHA03100  105 NGITPLLYAISK-KSNSYSIveYLLDNGAN--VNIKNSDGENLLHLYLesNKIDLKILKLLIDKGVDINAKNR------- 174

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   892 vaadygqsgaVALLLhRAKADLSLLDVNKNTALHLACSKAHEMCAMLILKEIHNPiliNATNSMLQMPLHIAARNGLATV 971
Cdd:PHA03100  175 ----------VNYLL-SYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANP---NLVNKYGDTPLHIAILNNNKEI 240

                         170
                  ....*....|....*.
gi 66392221   972 VQALLNRGATVLAVDE 987
Cdd:PHA03100  241 FKLLLNNGPSIKTIIE 256
Ank_4 pfam13637
Ankyrin repeats (many copies);
581-632 1.70e-06

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 46.11  E-value: 1.70e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 66392221    581 SPLHLAVESGHWECVTVLIESGVCVDVCDPVGRSVLYLASQRGHSRCVELLL 632
Cdd:pfam13637    3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 332-568 1.71e-06

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 52.01  E-value: 1.71e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221    332 IDCVDRYGNTPLHVAAKYG-HELLISTLMTNGadtaRQGIHGMFPLHLAVLyGSSDCCRKLLSSgQLYSIVLSMSKEHVL 410
Cdd:TIGR00870   45 INCPDRLGRSALFVAAIENeNLELTELLLNLS----CRGAVGDTLLHAISL-EYVDAVEAILLH-LLAAFRKSGPLELAN 118

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221    411 SAGFDINTPDnfgRTCLHAAASGGNIECLNLLLSSGADMNKKDK--------------FGRTPLHYAAANGRYQCVVVLV 476
Cdd:TIGR00870  119 DQYTSEFTPG---ITALHLAAHRQNYEIVKLLLERGASVPARACgdffvksqgvdsfyHGESPLNAAACLGSPSIVALLS 195

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221    477 GAGAEVNERDRSGCTPLHYSAASTAFcrtdrphasthqnQEDGEKESFLCVEHLLDNGADPC-------LCNTKGYSAVH 549
Cdd:TIGR00870  196 EDPADILTADSLGNTLLHLLVMENEF-------------KAEYEELSCQMYNFALSLLDKLRdskelevILNHQGLTPLK 262

                          250
                   ....*....|....*....
gi 66392221    550 YAAAHGNKQNLELLLEMCF 568
Cdd:TIGR00870  263 LAAKEGRIVLFRLKLAIKY 281
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 586-770 1.79e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 51.53  E-value: 1.79e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   586 AVESGHWECVTVLIESGVCVDVCDPVGRSVLYLASQRGHSRCVELLLSQSA--SCLLAEHRSkwgPLHVAAANGHSECLR 663
Cdd:PHA02875    9 AILFGELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAipDVKYPDIES---ELHDAVEEGDVKAVE 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   664 MLLCSEGGADlvNVTDAEGQTPLMLAVLGGHTDCVHLLLERGACPDMKDRRGRTALHRGAVMGREDCLTALLSHNVSVLS 743
Cdd:PHA02875   86 ELLDLGKFAD--DVFYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDI 163

                         170       180
                  ....*....|....*....|....*..
gi 66392221   744 RDFQGRSALHLAASCGHADILSNLLSA 770
Cdd:PHA02875  164 EDCCGCTPLIIAMAKGDIAICKMLLDS 190
Ank_5 pfam13857
Ankyrin repeats (many copies);
415-463 2.04e-06

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 45.80  E-value: 2.04e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 66392221    415 DINTPDNFGRTCLHAAASGGNIECLNLLLSSGADMNKKDKFGRTPLHYA 463
Cdd:pfam13857    8 DLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 409-489 2.19e-06

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 51.82  E-value: 2.19e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   409 VLSAGFDINTPDNFGRTCLHAAASGGNIECLNLLLSSGADMNKKDKFGRTPLHYAAANGRYQCVVVLVGAGAEVNERDRS 488
Cdd:PTZ00322  101 LLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRHSQCHFELGAN 180


                  .
gi 66392221   489 G 489
Cdd:PTZ00322  181 A 181
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 527-688 2.51e-06

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 51.79  E-value: 2.51e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   527 VEHLLDNGADPCLCNTKGYSAVHYAAAHGNKQNLELLLEMCFNtLGDKESNGSiSPLHLAVESGHWECVTVLIEsgvCVD 606
Cdd:PLN03192  541 LEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACN-VHIRDANGN-TALWNAISAKHHKIFRILYH---FAS 615

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   607 VCDP-VGRSVLYLASQRGHSRCVELLLSQSAScLLAEHRSKWGPLHVAAANGHSECLRMLLCSegGADLVNVTDAEGQTP 685
Cdd:PLN03192  616 ISDPhAAGDLLCTAAKRNDLTAMKELLKQGLN-VDSEDHQGATALQVAMAEDHVDMVRLLIMN--GADVDKANTDDDFSP 692


                  ...
gi 66392221   686 LML 688
Cdd:PLN03192  693 TEL 695
Ank_5 pfam13857
Ankyrin repeats (many copies);
92-147 2.55e-06

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 45.42  E-value: 2.55e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 66392221     92 LLLRKGADVTARDKYWQTPLHIAAANRATRCVETLLPHVSSLNMADRTGRAPLHHA 147
Cdd:pfam13857    1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PHA02946 PHA02946
ankyin-like protein; Provisional
 407-493 2.73e-06

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 51.21  E-value: 2.73e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   407 EHVLSAGFDINTPDNFGRTCLHAAASGGNIECLNLLLSSGADMNKKDKFGRTPLHYAAANGR--YQCVVVLVGAGAEVNE 484
Cdd:PHA02946   56 EELLHRGYSPNETDDDGNYPLHIASKINNNRIVAMLLTHGADPNACDKQHKTPLYYLSGTDDevIERINLLVQYGAKINN 135

                          90
                  ....*....|
gi 66392221   485 R-DRSGCTPL 493
Cdd:PHA02946  136 SvDEEGCGPL 145
TRPV1 cd22196
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 1; Vanilloid receptor 1 ...
 172-280 2.96e-06

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 1; Vanilloid receptor 1 (TRPV1), a capsaicin (vanilloid) receptor, is the founding member of the vanilloid TRP subfamily (TRPV). In humans, it is expressed in the brain, kidney, pancreas, testis, uterus, spleen, stomach, small intestine, lung and liver. TRPV1 has been implicated to have function in thermo-sensation (heat), autonomic thermoregulation, nociception, food intake regulation, and multiple functions in the gastrointestinal (GI) tract. The receptor has also been involved in growth cone guidance, long-term depression, endocannabinoid signaling and osmosensing in the central nervous system. TRPV1 is up regulated in several human pathological conditions including vulvodynia, GI inflammation, Crohn's disease and ulcerative colitis. TRPV1 knock-out mice exhibit impaired sensation to thermal-mechanical acute pain. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411980 [Multi-domain]  Cd Length: 649  Bit Score: 51.35  E-value: 2.96e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221  172 KDRQPIHWAAYLGHLEVVKLLVSQGSD----------KSCKDKRGY----TPLHAAAASGHVDVVKYLLRN---GAEIDE 234
Cdd:cd22196   93 KGQTALHIAIERRNMHLVELLVQNGADvharasgeffKKKKGGPGFyfgeLPLSLAACTNQLDIVKFLLENphsPADISA 172

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 66392221  235 PNAFGNTALH----VACYTGQEA-----VANELVNRGANVNQ-------PNHRGYTPLHLAA 280
Cdd:cd22196  173 RDSMGNTVLHalveVADNTPENTkfvtkMYNEILILGAKIRPllkleeiTNKKGLTPLKLAA 234
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 43-186 3.36e-06

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 51.17  E-value: 3.36e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   43 TPLHAAAWLGDVHIMDLLISAGANVNAK------------------DHvwltPLHRAAASRNERAVGLLLRKGADVTARD 104
Cdd:cd22192   91 TALHIAVVNQNLNLVRELIARGADVVSPratgtffrpgpknliyygEH----PLSFAACVGNEEIVRLLIEHGADIRAQD 166

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221  105 KYWQTPLHI----AAANRATRCVETLLPHVSSLN------MADRTGRAPLHHAAQSGYQEMVKLLLNKganlsasdkkdR 174
Cdd:cd22192  167 SLGNTVLHIlvlqPNKTFACQMYDLILSYDKEDDlqpldlVPNNQGLTPFKLAAKEGNIVMFQHLVQK-----------R 235

                        170
                 ....*....|..
gi 66392221  175 QPIHWAayLGHL 186
Cdd:cd22192  236 RHIQWT--YGPL 245
Ank_5 pfam13857
Ankyrin repeats (many copies);
202-246 3.89e-06

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 45.03  E-value: 3.89e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 66392221    202 KDKRGYTPLHAAAASGHVDVVKYLLRNGAEIDEPNAFGNTALHVA 246
Cdd:pfam13857   12 LDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
Ank_5 pfam13857
Ankyrin repeats (many copies);
258-313 4.08e-06

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 45.03  E-value: 4.08e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 66392221    258 LVNRGANVNQPNHRGYTPLHLAAvSTNGALCLELLVNNGADVNMQSKEGKSPLHMA 313
Cdd:pfam13857    2 LEHGPIDLNRLDGEGYTPLHVAA-KYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
TRPV2 cd22197
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 2; TRPV2 is closely ...
 140-280 4.17e-06

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 2; TRPV2 is closely related to TRPV1, sharing high sequence identity (>50%), but TRPV2 shows a higher temperature threshold and sensitivity for activation than TRPV1. TRPV2 can be stimulated by ligands or lipids, and is involved in osmosensation and mechanosensation. TRPV2 is expressed in both neuronal and non-neuronal tissues, and it has been implicated in diverse physiological and pathophysiological processes, including cardiac-structure maintenance, innate immunity, and cancer. TRPV2 belongs to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411981 [Multi-domain]  Cd Length: 640  Bit Score: 51.01  E-value: 4.17e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221  140 GRAPLHHAAQSGYQEMVKLLLNKGANLSASDKKD--RQPIHWAAYLGHLevvkllvsqgsdksckdkrgytPLHAAAASG 217
Cdd:cd22197   94 GHSALHIAIEKRSLQCVKLLVENGADVHARACGRffQKKQGTCFYFGEL----------------------PLSLAACTK 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221  218 HVDVVKYLLRNG---AEIDEPNAFGNTALHVACYTGQEAVAN---------ELVNRGANVNQ-------PNHRGYTPLHL 278
Cdd:cd22197  152 QWDVVNYLLENPhqpASLQAQDSLGNTVLHALVMIADNSPENsalvikmydGLLQAGARLCPtvqleeiSNHEGLTPLKL 231


                 ..
gi 66392221  279 AA 280
Cdd:cd22197  232 AA 233
Ank_4 pfam13637
Ankyrin repeats (many copies);
715-768 4.46e-06

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 44.96  E-value: 4.46e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 66392221    715 GRTALHRGAVMGREDCLTALLSHNVSVLSRDFQGRSALHLAASCGHADILSNLL 768
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02884 PHA02884
ankyrin repeat protein; Provisional
 56-195 5.87e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165212 [Multi-domain]  Cd Length: 300  Bit Score: 49.60  E-value: 5.87e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221    56 IMDLLISAGANVNAK----DHVWLTPLHRAAASRNERAVGLLLRKGADVTARDKYWQ-TPLHIAAANRATRCVETLLPHV 130
Cdd:PHA02884   48 IIDAILKLGADPEAPfplsENSKTNPLIYAIDCDNDDAAKLLIRYGADVNRYAEEAKiTPLYISVLHGCLKCLEILLSYG 127

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 66392221   131 SSLNMADRTGRAPLHHAAQSGYQEMVKLLlnKGANLSASDKkdrqpiHWAAYLGHLEVVKLLVSQ 195
Cdd:PHA02884  128 ADINIQTNDMVTPIELALMICNNFLAFMI--CDNEISNFYK------HPKKILINFDILKILVSH 184
PHA02716 PHA02716
CPXV016; CPX019; EVM010; Provisional
 45-276 6.48e-06

CPXV016; CPX019; EVM010; Provisional


Pssm-ID: 165089 [Multi-domain]  Cd Length: 764  Bit Score: 50.30  E-value: 6.48e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221    45 LHAaaWLG----DVHIMDLLISAGANVNAKDHVWLTPLHRAAASRNERAVGL--LLRKGADVTARDKYWQTPLHIAAANR 118
Cdd:PHA02716  181 LHA--YLGnmyvDIDILEWLCNNGVNVNLQNNHLITPLHTYLITGNVCASVIkkIIELGGDMDMKCVNGMSPIMTYIINI 258

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   119 ATRCVETLLPHVSSLNmADRTGRAPlhhaaqsgyqEMVKLLLNKGANLSASdkkdrqpihwaaylghleVVKLLVSQGSD 198
Cdd:PHA02716  259 DNINPEITNIYIESLD-GNKVKNIP----------MILHSYITLARNIDIS------------------VVYSFLQPGVK 309

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   199 KSCKDKRGYTPLHAAAASGHV--DVVKYLLRNGAEIDEPNAFGNTALHVacYTGQEAVANE----------------LVN 260
Cdd:PHA02716  310 LHYKDSAGRTCLHQYILRHNIstDIIKLLHEYGNDLNEPDNIGNTVLHT--YLSMLSVVNIldpetdndirldviqcLIS 387

                         250
                  ....*....|....*.
gi 66392221   261 RGANVNQPNHRGYTPL 276
Cdd:PHA02716  388 LGADITAVNCLGYTPL 403
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 734-988 6.75e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 50.06  E-value: 6.75e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   734 LLSHNVSVLSRDFQGRSALHLAASCGHADILSNLLS-AADHSqpqdpLTDRHGYTPAHWAAYHGHEDCLEVLLELKpcSI 812
Cdd:PHA02876  164 LLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSyGADVN-----IIALDDLSVLECAVDSKNIDTIKAIIDNR--SN 236

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   813 QEGNPFTPLHcALINGHSGSAELLLESSVCnslVNIRDAKGRTPLHAAAVAEDVAGL-QLVLRQGADIDAVDHSGRSALM 891
Cdd:PHA02876  237 INKNDLSLLK-AIRNEDLETSLLLYDAGFS---VNSIDDCKNTPLHHASQAPSLSRLvPKLLERGADVNAKNIKGETPLY 312

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   892 VAADYGQSGAVALLLHRAKADLSLLDVNKNTALHLACSKAHEMCAMLILKEIHNPIliNATNSMLQMPLHIAARNGLATV 971
Cdd:PHA02876  313 LMAKNGYDTENIRTLIMLGADVNAADRLYITPLHQASTLDRNKDIVITLLELGANV--NARDYCDKTPIHYAAVRNNVVI 390

                         250
                  ....*....|....*..
gi 66392221   972 VQALLNRGATVLAVDEE 988
Cdd:PHA02876  391 INTLLDYGADIEALSQK 407
Ank_5 pfam13857
Ankyrin repeats (many copies);
669-720 6.81e-06

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 44.26  E-value: 6.81e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 66392221    669 EGGADLVNVTDAEGQTPLMLAVLGGHTDCVHLLLERGACPDMKDRRGRTALH 720
Cdd:pfam13857    3 EHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALD 54
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 278-451 7.33e-06

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 50.25  E-value: 7.33e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   278 LAAVSTNGALCLELLVNNGADVNMQSKEGKSPLHMAAIHGRFTRSQILIQNGGEIDCVDRYGNTPLHVAAKYGHELLIST 357
Cdd:PLN03192  530 LTVASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRI 609

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   358 LMtngadtarqgihgmfplHLAVL---YGSSDCCRKLLSSGQLysivlSMSKEhVLSAGFDINTPDNFGRTCLHAAASGG 434
Cdd:PLN03192  610 LY-----------------HFASIsdpHAAGDLLCTAAKRNDL-----TAMKE-LLKQGLNVDSEDHQGATALQVAMAED 666

                         170
                  ....*....|....*..
gi 66392221   435 NIECLNLLLSSGADMNK 451
Cdd:PLN03192  667 HVDMVRLLIMNGADVDK 683
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 205-234 9.55e-06

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 43.35  E-value: 9.55e-06
                            10        20        30
                    ....*....|....*....|....*....|
gi 66392221     205 RGYTPLHAAAASGHVDVVKYLLRNGAEIDE 234
Cdd:smart00248    1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
Ank_4 pfam13637
Ankyrin repeats (many copies);
272-326 9.77e-06

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 43.80  E-value: 9.77e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 66392221    272 GYTPLHLAAVSTNGAlCLELLVNNGADVNMQSKEGKSPLHMAAIHGRFTRSQILI 326
Cdd:pfam13637    1 ELTALHAAAASGHLE-LLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 846-992 1.26e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 49.11  E-value: 1.26e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   846 VNIRDA-KGRTPLHAAAVAEDVAGLQLVLRQGADIDAVDHSGRSALMVAADYGQSGAVALLLhRAKADLSLLDVNKNTAL 924
Cdd:PHA02878  160 INMKDRhKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILL-ENGASTDARDKCGNTPL 238

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 66392221   925 HLACSKAHEMCAMLILKEihNPILINATNSMLQM-PLHIAARNglATVVQALLNRGATVLAVDEEGHTP 992
Cdd:PHA02878  239 HISVGYCKDYDILKLLLE--HGVDVNAKSYILGLtALHSSIKS--ERKLKLLLEYGADINSLNSYKLTP 303
Ank_5 pfam13857
Ankyrin repeats (many copies);
291-346 1.44e-05

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 43.49  E-value: 1.44e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 66392221    291 LLVNNGADVNMQSKEGKSPLHMAAIHGRFTRSQILIQNGGEIDCVDRYGNTPLHVA 346
Cdd:pfam13857    1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
TRPV1-4 cd22193
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 1-4; TRPV1-4 are ...
 186-280 1.70e-05

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 1-4; TRPV1-4 are thermo-sensing channels that function directly in temperature-sensing and nociception; they share substantial structural and functional properties. Transient Receptor Potential (TRP) ion channels activated by temperature (thermo TRPs) are important molecular players in acute, inflammatory, and chronic pain states. So far, 11 TRP channels in mammalian cells have been identified as thermosensitive TRP (thermo-TRP) channels. TRPV1-4 channels are activated by different heat temperatures, for example, TRPV1 and TRPV2 are activated by high temperatures (>43C and >55C, respectively). TRPV1-4 belong to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411977 [Multi-domain]  Cd Length: 607  Bit Score: 49.02  E-value: 1.70e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221  186 LEVVKLLVSQGSD---KSC------KDKRGY-----TPLHAAAASGHVDVVKYLLRNG---AEIDEPNAFGNTALHVACY 248
Cdd:cd22193   89 GDIVALLVENGADvhaHAKgrffqpKYQGEGfyfgeLPLSLAACTNQPDIVQYLLENEhqpADIEAQDSRGNTVLHALVT 168

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 66392221  249 TGQEAVAN---------ELVNRGANVNQP-------NHRGYTPLHLAA 280
Cdd:cd22193  169 VADNTKENtkfvtrmydMILIRGAKLCPTveleeirNNDGLTPLQLAA 216
PHA02946 PHA02946
ankyin-like protein; Provisional
 24-243 1.75e-05

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 48.51  E-value: 1.75e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221    24 VKLFLHKKDEVNALDQERRTPLHAAAWLGDVHIMDLLISAGANVNAKDHVWLTPLHRAAASRNE--RAVGLLLRKGADV- 100
Cdd:PHA02946   55 VEELLHRGYSPNETDDDGNYPLHIASKINNNRIVAMLLTHGADPNACDKQHKTPLYYLSGTDDEviERINLLVQYGAKIn 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   101 TARDKYWQTPLhIAAANRATRCVETLLPHVSSLNMADRTGRAPLHHAAQsgyqemvklllnkganlsaSDKKDRQPIHWa 180
Cdd:PHA02946  135 NSVDEEGCGPL-LACTDPSERVFKKIMSIGFEARIVDKFGKNHIHRHLM-------------------SDNPKASTISW- 193

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 66392221   181 aylghlevvklLVSQGSDKSCKDKRGYTPLHAAAAS--GHVDVVKYLLRNgAEIDEPNAFGNTAL 243
Cdd:PHA02946  194 -----------MMKLGISPSKPDHDGNTPLHIVCSKtvKNVDIINLLLPS-TDVNKQNKFGDSPL 246
Ank_4 pfam13637
Ankyrin repeats (many copies);
375-443 1.80e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 43.03  E-value: 1.80e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 66392221    375 PLHLAVLYGSSDCCRKLLSSGqlysivlsmskehvlsagFDINTPDNFGRTCLHAAASGGNIECLNLLL 443
Cdd:pfam13637    4 ALHAAAASGHLELLRLLLEKG------------------ADINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_5 pfam13857
Ankyrin repeats (many copies);
944-992 1.89e-05

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 43.10  E-value: 1.89e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 66392221    944 HNPILINATNSMLQMPLHIAARNGLATVVQALLNRGATVLAVDEEGHTP 992
Cdd:pfam13857    4 HGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTA 52
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 859-1010 2.07e-05

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 48.71  E-value: 2.07e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   859 AAAVAEDVAGLQLVLRQGADIDAVDHSGRSALMVAADYGQSGAVALLLHRAkADLSLLDVNKNTALHLACSKAHEMCAML 938
Cdd:PLN03192  531 TVASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHA-CNVHIRDANGNTALWNAISAKHHKIFRI 609

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 66392221   939 I--LKEIHNPiliNATNSMLQMplhiAARNGLATVVQALLNRGATVLAVDEEGHTpALACASNKAVADCLALIL 1010
Cdd:PLN03192  610 LyhFASISDP---HAAGDLLCT----AAKRNDLTAMKELLKQGLNVDSEDHQGAT-ALQVAMAEDHVDMVRLLI 675
Ank_4 pfam13637
Ankyrin repeats (many copies);
109-160 2.44e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 42.65  E-value: 2.44e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 66392221    109 TPLHIAAANRATRCVETLLPHVSSLNMADRTGRAPLHHAAQSGYQEMVKLLL 160
Cdd:pfam13637    3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_5 pfam13857
Ankyrin repeats (many copies);
158-213 2.59e-05

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 42.72  E-value: 2.59e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 66392221    158 LLLNKGANLSASDKKDRQPIHWAAYLGHLEVVKLLVSQGSDKSCKDKRGYTPLHAA 213
Cdd:pfam13857    1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 205-236 2.90e-05

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 41.89  E-value: 2.90e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 66392221    205 RGYTPLHAAAAS-GHVDVVKYLLRNGAEIDEPN 236
Cdd:pfam00023    1 DGNTPLHLAAGRrGNLEIVKLLLSKGADVNARD 33
Ank_4 pfam13637
Ankyrin repeats (many copies);
339-392 3.15e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 42.26  E-value: 3.15e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 66392221    339 GNTPLHVAAKYGHELLISTLMTNGADTARQGIHGMFPLHLAVLYGSSDCCRKLL 392
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 819-992 3.22e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 47.65  E-value: 3.22e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   819 TPLHCALINGHSGSAELLLESsvcNSLVNIRDAKGRTPLHAAAVAEDVAGLQLVLRQGADIDAVDHSGRSALMVAADYGQ 898
Cdd:PHA02874  126 TFLHYAIKKGDLESIKMLFEY---GADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGD 202

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   899 SGAVALLLHRAkADLSLLDVNKNTALHLACSKAHEMCAMLIlkeihNPILINATNSMLQMPLHIAARNGLAT-VVQALLN 977
Cdd:PHA02874  203 YACIKLLIDHG-NHIMNKCKNGFTPLHNAIIHNRSAIELLI-----NNASINDQDIDGSTPLHHAINPPCDIdIIDILLY 276

                         170
                  ....*....|....*
gi 66392221   978 RGATVLAVDEEGHTP 992
Cdd:PHA02874  277 HKADISIKDNKGENP 291
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 173-443 3.31e-05

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 48.15  E-value: 3.31e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221    173 DRQPIHWAAYlGHLEVVK--LLVSQGSDKSCKDKRGYTPLHAAAASG-HVDVVKYLLRNGAEIDEpnafGNTALHVACYT 249
Cdd:TIGR00870   18 EKAFLPAAER-GDLASVYrdLEEPKKLNINCPDRLGRSALFVAAIENeNLELTELLLNLSCRGAV----GDTLLHAISLE 92

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221    250 GQEAVaNELvnrgANVNQPNHRGYTPLHLAavstngalclellvnngadvNMQSK----EGKSPLHMAAIHGRFTRSQIL 325
Cdd:TIGR00870   93 YVDAV-EAI----LLHLLAAFRKSGPLELA--------------------NDQYTseftPGITALHLAAHRQNYEIVKLL 147

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221    326 IQNGGEI-------DCVD-------RYGNTPLHVAAKYGHELLISTLMTNGADTARQGIHGMFPLHLAVLYGSSDCCRKL 391
Cdd:TIGR00870  148 LERGASVparacgdFFVKsqgvdsfYHGESPLNAAACLGSPSIVALLSEDPADILTADSLGNTLLHLLVMENEFKAEYEE 227

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 66392221    392 LSSgQLYSIVL--------SMSKEHVLsagfdintpdNF-GRTCLHAAASGGNIECLNLLL 443
Cdd:TIGR00870  228 LSC-QMYNFALslldklrdSKELEVIL----------NHqGLTPLKLAAKEGRIVLFRLKL 277
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 205-234 3.60e-05

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 41.47  E-value: 3.60e-05
                           10        20        30
                   ....*....|....*....|....*....|
gi 66392221    205 RGYTPLHAAAASGHVDVVKYLLRNGAEIDE 234
Cdd:pfam13606    1 DGNTPLHLAARNGRLEIVKLLLENGADINA 30
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 888-982 3.88e-05

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 47.70  E-value: 3.88e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221  888 SALMVAADYGQSGAVALLLHRAKADLSLLDVNKNTALHLACSKAHEMCAMLILKEIhnPILIN--ATNSMLQ--MPLHIA 963
Cdd:cd22192   19 SPLLLAAKENDVQAIKKLLKCPSCDLFQRGALGETALHVAALYDNLEAAVVLMEAA--PELVNepMTSDLYQgeTALHIA 96

                         90
                 ....*....|....*....
gi 66392221  964 ARNGLATVVQALLNRGATV 982
Cdd:cd22192   97 VVNQNLNLVRELIARGADV 115
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 861-927 5.56e-05

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 47.20  E-value: 5.56e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 66392221   861 AVAEDVAGLQLVLRQGADIDAVDHSGRSALMVAADYGQSGAVALLLHRAkADLSLLDVNKNTALHLA 927
Cdd:PTZ00322   90 AASGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFG-ADPTLLDKDGKTPLELA 155
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 271-304 6.62e-05

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 40.74  E-value: 6.62e-05
                           10        20        30
                   ....*....|....*....|....*....|....
gi 66392221    271 RGYTPLHLAAVSTNGALCLELLVNNGADVNMQSK 304
Cdd:pfam00023    1 DGNTPLHLAAGRRGNLEIVKLLLSKGADVNARDK 34
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 112-206 7.43e-05

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 46.82  E-value: 7.43e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   112 HIAAANRATRcVETLLPHVSSLNMADRTGRAPLHHAAQSGYQEMVKLLLNKGANLSASDKKDRQPIHWAAYLGHLEVVKL 191
Cdd:PTZ00322   88 QLAASGDAVG-ARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQL 166

                          90
                  ....*....|....*
gi 66392221   192 LVSQGSDKSCKDKRG 206
Cdd:PTZ00322  167 LSRHSQCHFELGANA 181
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 423-451 7.72e-05

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 40.65  E-value: 7.72e-05
                            10        20
                    ....*....|....*....|....*....
gi 66392221     423 GRTCLHAAASGGNIECLNLLLSSGADMNK 451
Cdd:smart00248    2 GRTPLHLAAENGNLEVVKLLLDKGADINA 30
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 311-399 8.37e-05

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 46.82  E-value: 8.37e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   311 HMAAiHGRFTRSQILIQNGGEIDCVDRYGNTPLHVAAKYGHELLISTLMTNGADTARQGIHGMFPLHLAVLYGSSDCCRK 390
Cdd:PTZ00322   88 QLAA-SGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQL 166


                  ....*....
gi 66392221   391 LLSSGQLYS 399
Cdd:PTZ00322  167 LSRHSQCHF 175
TRPV cd21882
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily ...
 237-443 1.17e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily (TRPV), named after the vanilloid receptor 1 (TRPV1), consists of six members: four thermo-sensing channels (TRPV1, TRPV2, TRPV3, and TRPV4) and two Ca2+ selective channels (TRPV5 and TRPV6). The calcium-selective channels TRPV5 and TRPV6 can be heterotetramers and are important for general Ca2+ homeostasis. All four channels within the TRPV1-4 group show temperature-invoked currents when expressed in heterologous cell systems, ranging from activation at ~25C for TRPV4 to ~52C for TRPV2. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains. The TRP family consists of membrane proteins that function as ion channels that communicate between the cell and its environment, by a vast array of physical or chemical stimuli, including radiation (in the form of temperature, infrared ,or light) and pressure (osmotic or mechanical). TRP channels are formed by a tetrameric complex of channel subunits. Based on sequence identity, the mammalian TRP channel family is classified into six subfamilies, with significant sequence similarity within the transmembrane domains, but very low similarity in their N- and C-terminal cytoplasmic regions. The six subfamilies are named based on their first member: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPA (ankyrin), TRPML (mucolipin), and TRPP (polycystic).


Pssm-ID: 411975 [Multi-domain]  Cd Length: 600  Bit Score: 46.03  E-value: 1.17e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221  237 AFGNTALHVACYTGQEA----------VANELVNRGANVNQPN----HRGYTPLHLAAVSTNgALCLELLVNNGADVnmq 302
Cdd:cd21882   24 ATGKTCLHKAALNLNDGvneaimllleAAPDSGNPKELVNAPCtdefYQGQTALHIAIENRN-LNLVRLLVENGADV--- 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221  303 skegksplHMAAIHGRFTRSQIliqnggeiDCVdRYGNTPLHVAAKYGHELLISTLMTNGADTA---RQGIHGMFPLHLA 379
Cdd:cd21882  100 --------SARATGRFFRKSPG--------NLF-YFGELPLSLAACTNQEEIVRLLLENGAQPAaleAQDSLGNTVLHAL 162

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 66392221  380 VLYGSSDCCRKLLSSgQLYSIVLSMSKEHVLSAGFDInTPDNFGRTCLHAAASGGNIECLNLLL 443
Cdd:cd21882  163 VLQADNTPENSAFVC-QMYNLLLSYGAHLDPTQQLEE-IPNHQGLTPLKLAAVEGKIVMFQHIL 224
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 430-565 1.24e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 46.16  E-value: 1.24e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221  430 AASGGNIECLN-LLLSSGADMNKKDKFGRTPLHYAAANGRYQCVVVLVGAGAE-VNERDRS----GCTPLHYSAAstafc 503
Cdd:cd22192   24 AAKENDVQAIKkLLKCPSCDLFQRGALGETALHVAALYDNLEAAVVLMEAAPElVNEPMTSdlyqGETALHIAVV----- 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221  504 rtdrphasthqnqedgeKESFLCVEHLLDNGADP---------------CLCntkgYSAVH---YAAAHGNKQNLELLLE 565
Cdd:cd22192   99 -----------------NQNLNLVRELIARGADVvspratgtffrpgpkNLI----YYGEHplsFAACVGNEEIVRLLIE 157
PHA02791 PHA02791
ankyrin-like protein; Provisional
 136-227 1.36e-04

ankyrin-like protein; Provisional


Pssm-ID: 165154 [Multi-domain]  Cd Length: 284  Bit Score: 45.03  E-value: 1.36e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   136 ADRTGRAPLHHAAQSGYQEMVKLLLNKGA--NLSasdkKDRQPIHWAAYLGHLEVVKLLVSQGSDKSCKDKRGYTPLHAA 213
Cdd:PHA02791   26 ADVHGHSALYYAIADNNVRLVCTLLNAGAlkNLL----ENEFPLHQAATLEDTKIVKILLFSGMDDSQFDDKGNTALYYA 101

                          90
                  ....*....|....
gi 66392221   214 AASGHVDVVKYLLR 227
Cdd:PHA02791  102 VDSGNMQTVKLFVK 115
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 664-999 1.40e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 45.82  E-value: 1.40e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   664 MLLcsEGGADlVNVTDAEGQTPLMLAVLGGHTDCVHLLLERGACPDMKDRRGRTALHRGAVMGREDCLTALLSHNVSVLS 743
Cdd:PHA02876  163 MLL--EGGAD-VNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNRSNINK 239

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   744 RDfqgrsaLHLAASCGHADILSNLLsAADHSQPQDPLtDRHGYTPAHWAAYhghedclevllelkpcsiqegnpfTPLHC 823
Cdd:PHA02876  240 ND------LSLLKAIRNEDLETSLL-LYDAGFSVNSI-DDCKNTPLHHASQ------------------------APSLS 287

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   824 ALINGhsgsaelLLESSVCnslVNIRDAKGRTPLH-AAAVAEDVAGLQLVLRQGADIDAVDHSGRSALMVAADYGQSGAV 902
Cdd:PHA02876  288 RLVPK-------LLERGAD---VNAKNIKGETPLYlMAKNGYDTENIRTLIMLGADVNAADRLYITPLHQASTLDRNKDI 357

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   903 ALLLHRAKADLSLLDVNKNTALHLACSKAHEMcamlilkeIHNPIL-----INATNSMLQMPLHIA-ARNGLATVVQALL 976
Cdd:PHA02876  358 VITLLELGANVNARDYCDKTPIHYAAVRNNVV--------IINTLLdygadIEALSQKIGTALHFAlCGTNPYMSVKTLI 429

                         330       340
                  ....*....|....*....|....
gi 66392221   977 NRGATVLAVDEEGHTPA-LACASN 999
Cdd:PHA02876  430 DRGANVNSKNKDLSTPLhYACKKN 453
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 609-741 1.51e-04

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 46.01  E-value: 1.51e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   609 DPVGRSVLYLASQRGHSRCVELLLSQSASCLLAEHRSKwGPLHVAAANGHSECLRMLL---CSeggadlVNVTDAEGQTP 685
Cdd:PLN03192  522 DPNMASNLLTVASTGNAALLEELLKAKLDPDIGDSKGR-TPLHIAASKGYEDCVLVLLkhaCN------VHIRDANGNTA 594

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   686 LMLAVLGGHTD-------CVHL------------------------LLERGACPDMKDRRGRTALHRGAVMGREDCLTAL 734
Cdd:PLN03192  595 LWNAISAKHHKifrilyhFASIsdphaagdllctaakrndltamkeLLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLL 674


                  ....*..
gi 66392221   735 LSHNVSV 741
Cdd:PLN03192  675 IMNGADV 681
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 816-1011 1.66e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 45.37  E-value: 1.66e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   816 NPFTPLHCALINGHSGSAELLLESsvcNSLVNIRDAKGRTPLHAAAVAEDVAGLQLVLRQGADIDAVDHS-GRSALMVAA 894
Cdd:PHA02875   34 DGISPIKLAMKFRDSEAIKLLMKH---GAIPDVKYPDIESELHDAVEEGDVKAVEELLDLGKFADDVFYKdGMTPLHLAT 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   895 DYGQSGAVALLLHRaKADLSLLDVNKNTALHLAC-SKAHEMCAMLIlkeIHNPILiNATNSMLQMPLHIAARNGLATVVQ 973
Cdd:PHA02875  111 ILKKLDIMKLLIAR-GADPDIPNTDKFSPLHLAVmMGDIKGIELLI---DHKACL-DIEDCCGCTPLIIAMAKGDIAICK 185

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 66392221   974 ALLNRGATVLAVDEEGHTPALACASNKAVADCLALILS 1011
Cdd:PHA02875  186 MLLDSGANIDYFGKNGCVAALCYAIENNKIDIVRLFIK 223
TRPV3 cd22194
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a ...
 56-248 1.81e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a temperature-sensitive Transient Receptor Potential (TRP) ion channel that is activated by warm temperatures, synthetic small-molecule chemicals, and natural compounds from plants. TRPV3 function is regulated by physiological factors such as extracellular divalent cations and acidic pH, intracellular adenosine triphosphate, membrane voltage, and arachidonic acid. It is expressed in both neuronal and non-neuronal tissues including epidermal keratinocytes, epithelial cells in the gut, endothelial cells in blood vessels, and neurons in dorsal root ganglia and CNS. TRPV3 null mice have abnormal hair morphogenesis and compromised skin barrier function. It may play roles in inflammatory skin disorders, such as itch and pain sensation. TRPV3 is also expressed by many neuronal and non-neuronal tissues, showing that TRPV3 might play roles in other unknown cellular and physiological functions. TRPV3 belongs to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411978 [Multi-domain]  Cd Length: 680  Bit Score: 45.52  E-value: 1.81e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   56 IMDLLISAgaNVNAKDHVWLTPLHRAAASRNERAVGLLLRKGADVTARDK--------------YWQTPLHIAAANRATR 121
Cdd:cd22194  125 ILDRFINA--EYTEEAYEGQTALNIAIERRQGDIVKLLIAKGADVNAHAKgvffnpkykhegfyFGETPLALAACTNQPE 202

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221  122 CVETLLPHVSS-LNMADRTGRAPLHH----AAQSGYQ--------EMVkLLLNKGANLSA-SDKKDRQPIHWAAYLGHLE 187
Cdd:cd22194  203 IVQLLMEKESTdITSQDSRGNTVLHAlvtvAEDSKTQndfvkrmyDMI-LLKSENKNLETiRNNEGLTPLQLAAKMGKAE 281

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 66392221  188 VVKLLVSQgsDKSCKDKRGYTPLHAAAASGHVDVVKYLLrNGAEIDEPnafgNTALHVACY 248
Cdd:cd22194  282 ILKYILSR--EIKEKPNRSLSRKFTDWAYGPVSSSLYDL-TNVDTTTD----NSVLEIIVY 335
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 681-713 1.86e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 39.58  E-value: 1.86e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 66392221    681 EGQTPLMLAVL-GGHTDCVHLLLERGACPDMKDR 713
Cdd:pfam00023    1 DGNTPLHLAAGrRGNLEIVKLLLSKGADVNARDK 34
TRPV cd21882
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily ...
 423-537 1.96e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily (TRPV), named after the vanilloid receptor 1 (TRPV1), consists of six members: four thermo-sensing channels (TRPV1, TRPV2, TRPV3, and TRPV4) and two Ca2+ selective channels (TRPV5 and TRPV6). The calcium-selective channels TRPV5 and TRPV6 can be heterotetramers and are important for general Ca2+ homeostasis. All four channels within the TRPV1-4 group show temperature-invoked currents when expressed in heterologous cell systems, ranging from activation at ~25C for TRPV4 to ~52C for TRPV2. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains. The TRP family consists of membrane proteins that function as ion channels that communicate between the cell and its environment, by a vast array of physical or chemical stimuli, including radiation (in the form of temperature, infrared ,or light) and pressure (osmotic or mechanical). TRP channels are formed by a tetrameric complex of channel subunits. Based on sequence identity, the mammalian TRP channel family is classified into six subfamilies, with significant sequence similarity within the transmembrane domains, but very low similarity in their N- and C-terminal cytoplasmic regions. The six subfamilies are named based on their first member: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPA (ankyrin), TRPML (mucolipin), and TRPP (polycystic).


Pssm-ID: 411975 [Multi-domain]  Cd Length: 600  Bit Score: 45.26  E-value: 1.96e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221  423 GRTCLHAAA---SGGNIECLNLLLSSGADMNKKDKF-----------GRTPLHYAAANGRYQCVVVLVGAGAEVNER--- 485
Cdd:cd21882   26 GKTCLHKAAlnlNDGVNEAIMLLLEAAPDSGNPKELvnapctdefyqGQTALHIAIENRNLNLVRLLVENGADVSARatg 105

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 66392221  486 ---DRSGCTPLHYSAASTAFCrtdrphASThqNQEDgekesflCVEHLLDNGADP 537
Cdd:cd21882  106 rffRKSPGNLFYFGELPLSLA------ACT--NQEE-------IVRLLLENGAQP 145
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 423-454 2.40e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 39.19  E-value: 2.40e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 66392221    423 GRTCLHAAA-SGGNIECLNLLLSSGADMNKKDK 454
Cdd:pfam00023    2 GNTPLHLAAgRRGNLEIVKLLLSKGADVNARDK 34
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 42-72 2.52e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 39.19  E-value: 2.52e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 66392221     42 RTPLHAAAW-LGDVHIMDLLISAGANVNAKDH 72
Cdd:pfam00023    3 NTPLHLAAGrRGNLEIVKLLLSKGADVNARDK 34
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 827-915 2.60e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 44.89  E-value: 2.60e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   827 NGHSGSAELLLESSV-CNSlvniRDAKGRTPLHAAAVAEDVAGLQLVLRQGADIDAVDHSGRSALMVAADYGQSGAVALL 905
Cdd:PTZ00322   92 SGDAVGARILLTGGAdPNC----RDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLL 167

                          90
                  ....*....|
gi 66392221   906 LHRAKADLSL 915
Cdd:PTZ00322  168 SRHSQCHFEL 177
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 214-314 2.76e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 44.89  E-value: 2.76e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   214 AASGHVDVVKYLLRNGAEIDEPNAFGNTALHVACYTGQEAVANELVNRGANVNQPNHRGYTPLHLAAVSTNGALcLELLV 293
Cdd:PTZ00322   90 AASGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREV-VQLLS 168

                          90       100       110
                  ....*....|....*....|....*....|....
gi 66392221   294 -------NNGADVNMQSKEGK------SPLHMAA 314
Cdd:PTZ00322  169 rhsqchfELGANAKPDSFTGKppsledSPISSHH 202
PHA02859 PHA02859
ankyrin repeat protein; Provisional
 265-426 3.05e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165195 [Multi-domain]  Cd Length: 209  Bit Score: 43.27  E-value: 3.05e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   265 VNQPNHRGYTPLHLAAVSTNGAL-CLELLVNNGADVNMQSK-EGKSPLHMAAIHGRFTRS---QILIQNGGEIDCVDRYG 339
Cdd:PHA02859   44 VNDCNDLYETPIFSCLEKDKVNVeILKFLIENGADVNFKTRdNNLSALHHYLSFNKNVEPeilKILIDSGSSITEEDEDG 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   340 NTPLHVaakYGHEL-----LISTLMTNGADTARQGIHGMFPLHLAVLYGSSDccrkllssgqlySIVlsmskEHVLSAGF 414
Cdd:PHA02859  124 KNLLHM---YMCNFnvrinVIKLLIDSGVSFLNKDFDNNNILYSYILFHSDK------------KIF-----DFLTSLGI 183

                         170
                  ....*....|..
gi 66392221   415 DINTPDNFGRTC 426
Cdd:PHA02859  184 DINETNKSGYNC 195
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 547-691 3.91e-04

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 44.69  E-value: 3.91e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221    547 AVHYAAAHGNKQNLELLLEMCFNTlgdkESNGsISPLHLAVESGHWECVTVLIESGVCVDVcdpvgrsvlylasqRGHsr 626
Cdd:TIGR00870  101 LLHLLAAFRKSGPLELANDQYTSE----FTPG-ITALHLAAHRQNYEIVKLLLERGASVPA--------------RAC-- 159

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 66392221    627 CVELLLSQSASCL-LAEHrskwgPLHVAAANGHSECLRMLlcSEGGADlVNVTDAEGQTPLMLAVL 691
Cdd:TIGR00870  160 GDFFVKSQGVDSFyHGES-----PLNAAACLGSPSIVALL--SEDPAD-ILTADSLGNTLLHLLVM 217
PHA02791 PHA02791
ankyrin-like protein; Provisional
 99-247 3.92e-04

ankyrin-like protein; Provisional


Pssm-ID: 165154 [Multi-domain]  Cd Length: 284  Bit Score: 43.49  E-value: 3.92e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221    99 DVTARDKYWQTPLHIAAANRATRCVETLLPHVSSLNMADrtGRAPLHHAAQSGYQEMVKLLLNKGANLSASDKKDRQPIH 178
Cdd:PHA02791   22 DAFKADVHGHSALYYAIADNNVRLVCTLLNAGALKNLLE--NEFPLHQAATLEDTKIVKILLFSGMDDSQFDDKGNTALY 99

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   179 WAAYLGHLEVVKLLVSQGSDKSCKDKRGY-TPLHAAAASGHVDVVKYLLrngAEIdePNAFgNTALHVAC 247
Cdd:PHA02791  100 YAVDSGNMQTVKLFVKKNWRLMFYGKTGWkTSFYHAVMLNDVSIVSYFL---SEI--PSTF-DLAILLSC 163
Ank_4 pfam13637
Ankyrin repeats (many copies);
853-906 4.18e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 39.18  E-value: 4.18e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 66392221    853 GRTPLHAAAVAEDVAGLQLVLRQGADIDAVDHSGRSALMVAADYGQSGAVALLL 906
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02743 PHA02743
Viral ankyrin protein; Provisional
 233-363 4.70e-04

Viral ankyrin protein; Provisional


Pssm-ID: 222925 [Multi-domain]  Cd Length: 166  Bit Score: 42.11  E-value: 4.70e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   233 DEPNAFgntalHVACYTGQeavANELV-------NRGANVNQPNHRGYTPLHLAAV--STNGALCLELLVNNGADVNM-Q 302
Cdd:PHA02743   19 DEQNTF-----LRICRTGN---IYELMevapfisGDGHLLHRYDHHGRQCTHMVAWydRANAVMKIELLVNMGADINArE 90

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 66392221   303 SKEGKSPLHMAAIHGRFTRSQILIQN-GGEIDCVDRYGNTPLHVAAKYGHELLISTLMTNGA 363
Cdd:PHA02743   91 LGTGNTLLHIAASTKNYELAEWLCRQlGVNLGAINYQHETAYHIAYKMRDRRMMEILRANGA 152
TRPV1 cd22196
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 1; Vanilloid receptor 1 ...
 270-344 5.35e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 1; Vanilloid receptor 1 (TRPV1), a capsaicin (vanilloid) receptor, is the founding member of the vanilloid TRP subfamily (TRPV). In humans, it is expressed in the brain, kidney, pancreas, testis, uterus, spleen, stomach, small intestine, lung and liver. TRPV1 has been implicated to have function in thermo-sensation (heat), autonomic thermoregulation, nociception, food intake regulation, and multiple functions in the gastrointestinal (GI) tract. The receptor has also been involved in growth cone guidance, long-term depression, endocannabinoid signaling and osmosensing in the central nervous system. TRPV1 is up regulated in several human pathological conditions including vulvodynia, GI inflammation, Crohn's disease and ulcerative colitis. TRPV1 knock-out mice exhibit impaired sensation to thermal-mechanical acute pain. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411980 [Multi-domain]  Cd Length: 649  Bit Score: 44.03  E-value: 5.35e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221  270 HRGYTPLHLAAVSTNGALcLELLVNNGADVNM--------QSKE------GKSPLHMAAIHGRFTRSQILIQN---GGEI 332
Cdd:cd22196   92 YKGQTALHIAIERRNMHL-VELLVQNGADVHArasgeffkKKKGgpgfyfGELPLSLAACTNQLDIVKFLLENphsPADI 170

                         90
                 ....*....|..
gi 66392221  333 DCVDRYGNTPLH 344
Cdd:cd22196  171 SARDSMGNTVLH 182
Ank_5 pfam13857
Ankyrin repeats (many copies);
225-279 5.56e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 38.87  E-value: 5.56e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 66392221    225 LLRNG-AEIDEPNAFGNTALHVACYTGQEAVANELVNRGANVNQPNHRGYTPLHLA 279
Cdd:pfam13857    1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
Ank_4 pfam13637
Ankyrin repeats (many copies);
239-293 5.61e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 38.79  E-value: 5.61e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 66392221    239 GNTALHVACYTGQEAVANELVNRGANVNQPNHRGYTPLHLAAVSTNGAlCLELLV 293
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVE-VLKLLL 54
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 9-173 6.46e-04

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 43.70  E-value: 6.46e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221     9 QPPLVQAIFNRNADEV---KLFLHKKDEVNALD---------QERRTPLHAA-----AWLGDVHIMDLLISAGANVNAKD 71
Cdd:PLN03192  476 TSTLIEAMQTRQEDNVvilKNFLQHHKELHDLNvgdllgdngGEHDDPNMASnlltvASTGNAALLEELLKAKLDPDIGD 555

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221    72 HVWLTPLHRAAASRNERAVGLLLRKGADVTARDKYWQTPL----------------HIAAANR-----------ATR--- 121
Cdd:PLN03192  556 SKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALwnaisakhhkifrilyHFASISDphaagdllctaAKRndl 635

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 66392221   122 -CVETLLPHVSSLNMADRTGRAPLHHAAQSGYQEMVKLLLNKGANLSASDKKD 173
Cdd:PLN03192  636 tAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADVDKANTDD 688
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 239-266 6.83e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 37.95  E-value: 6.83e-04
                            10        20
                    ....*....|....*....|....*...
gi 66392221     239 GNTALHVACYTGQEAVANELVNRGANVN 266
Cdd:smart00248    2 GRTPLHLAAENGNLEVVKLLLDKGADIN 29
TRPV3 cd22194
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a ...
 258-444 7.44e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a temperature-sensitive Transient Receptor Potential (TRP) ion channel that is activated by warm temperatures, synthetic small-molecule chemicals, and natural compounds from plants. TRPV3 function is regulated by physiological factors such as extracellular divalent cations and acidic pH, intracellular adenosine triphosphate, membrane voltage, and arachidonic acid. It is expressed in both neuronal and non-neuronal tissues including epidermal keratinocytes, epithelial cells in the gut, endothelial cells in blood vessels, and neurons in dorsal root ganglia and CNS. TRPV3 null mice have abnormal hair morphogenesis and compromised skin barrier function. It may play roles in inflammatory skin disorders, such as itch and pain sensation. TRPV3 is also expressed by many neuronal and non-neuronal tissues, showing that TRPV3 might play roles in other unknown cellular and physiological functions. TRPV3 belongs to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411978 [Multi-domain]  Cd Length: 680  Bit Score: 43.59  E-value: 7.44e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221  258 LVNrgANVNQPNHRGYTPLHLAAVSTNGALcLELLVNNGADVNMQSKegksplhmaaihGRFtrsqilIQNGGEIDCVdR 337
Cdd:cd22194  129 FIN--AEYTEEAYEGQTALNIAIERRQGDI-VKLLIAKGADVNAHAK------------GVF------FNPKYKHEGF-Y 186

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221  338 YGNTPLHVAAKYGHELLISTLMTNGADT-ARQGIHGMFPLHlAVLYGSSDCCRKLLSSGQLYSIVLSMSKEHVLSAgfdi 416
Cdd:cd22194  187 FGETPLALAACTNQPEIVQLLMEKESTDiTSQDSRGNTVLH-ALVTVAEDSKTQNDFVKRMYDMILLKSENKNLET---- 261

                        170       180
                 ....*....|....*....|....*...
gi 66392221  417 nTPDNFGRTCLHAAASGGNIECLNLLLS 444
Cdd:cd22194  262 -IRNNEGLTPLQLAAKMGKAEILKYILS 288
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 687-769 8.22e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 43.35  E-value: 8.22e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   687 MLAV----LGGHTDCV--HLLLERGACPDMKDRRGRTALHRGAVMGREDCLTALLSHNVSVLSRDFQGRSALHLAASCGH 760
Cdd:PTZ00322   81 MLTVelcqLAASGDAVgaRILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGF 160


                  ....*....
gi 66392221   761 ADILSNLLS 769
Cdd:PTZ00322  161 REVVQLLSR 169
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 456-484 8.47e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 37.57  E-value: 8.47e-04
                            10        20
                    ....*....|....*....|....*....
gi 66392221     456 GRTPLHYAAANGRYQCVVVLVGAGAEVNE 484
Cdd:smart00248    2 GRTPLHLAAENGNLEVVKLLLDKGADINA 30
PHA02859 PHA02859
ankyrin repeat protein; Provisional
 232-344 8.93e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165195 [Multi-domain]  Cd Length: 209  Bit Score: 41.73  E-value: 8.93e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   232 IDEPNAFGNTALHvACYTgQEAVANE----LVNRGANVN-QPNHRGYTPLHlAAVSTNGAL---CLELLVNNGADVNMQS 303
Cdd:PHA02859   44 VNDCNDLYETPIF-SCLE-KDKVNVEilkfLIENGADVNfKTRDNNLSALH-HYLSFNKNVepeILKILIDSGSSITEED 120

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 66392221   304 KEGKSPLH--MAAIHGRFTRSQILIQNGGEIDCVDRYGNTPLH 344
Cdd:PHA02859  121 EDGKNLLHmyMCNFNVRINVIKLLIDSGVSFLNKDFDNNNILY 163
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 140-171 9.30e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 37.65  E-value: 9.30e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 66392221    140 GRAPLHHAA-QSGYQEMVKLLLNKGANLSASDK 171
Cdd:pfam00023    2 GNTPLHLAAgRRGNLEIVKLLLSKGADVNARDK 34
TRPV1-4 cd22193
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 1-4; TRPV1-4 are ...
 270-344 9.73e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 1-4; TRPV1-4 are thermo-sensing channels that function directly in temperature-sensing and nociception; they share substantial structural and functional properties. Transient Receptor Potential (TRP) ion channels activated by temperature (thermo TRPs) are important molecular players in acute, inflammatory, and chronic pain states. So far, 11 TRP channels in mammalian cells have been identified as thermosensitive TRP (thermo-TRP) channels. TRPV1-4 channels are activated by different heat temperatures, for example, TRPV1 and TRPV2 are activated by high temperatures (>43C and >55C, respectively). TRPV1-4 belong to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411977 [Multi-domain]  Cd Length: 607  Bit Score: 43.25  E-value: 9.73e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221  270 HRGYTPLHLAAVSTNGAlCLELLVNNGADVNMQSKE--------------GKSPLHMAAIHGRFTRSQILIQNG---GEI 332
Cdd:cd22193   74 YEGQTALHIAIERRQGD-IVALLVENGADVHAHAKGrffqpkyqgegfyfGELPLSLAACTNQPDIVQYLLENEhqpADI 152

                         90
                 ....*....|..
gi 66392221  333 DCVDRYGNTPLH 344
Cdd:cd22193  153 EAQDSRGNTVLH 164
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 878-982 1.10e-03

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 43.15  E-value: 1.10e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221    878 DIDAVDHSGRSALMVAADYGQSGAVA--LLLHRAKADLSlldvnkNTALHLACSKAHEMCAMLIL------KEIHNPILI 949
Cdd:TIGR00870   44 NINCPDRLGRSALFVAAIENENLELTelLLNLSCRGAVG------DTLLHAISLEYVDAVEAILLhllaafRKSGPLELA 117

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 66392221    950 NA----TNSMLQMPLHIAARNGLATVVQALLNRGATV 982
Cdd:TIGR00870  118 NDqytsEFTPGITALHLAAHRQNYEIVKLLLERGASV 154
PHA02859 PHA02859
ankyrin repeat protein; Provisional
 104-239 1.21e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165195 [Multi-domain]  Cd Length: 209  Bit Score: 41.34  E-value: 1.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   104 DKYWQTPLH--IAAANRATRCVETLLPHVSSLNMADR-TGRAPLHHAA---QSGYQEMVKLLLNKGANLSASDKKDRQPI 177
Cdd:PHA02859   48 NDLYETPIFscLEKDKVNVEILKFLIENGADVNFKTRdNNLSALHHYLsfnKNVEPEILKILIDSGSSITEEDEDGKNLL 127

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 66392221   178 HwaAYLGH----LEVVKLLVSQGSDKSCKDKRGYTPLHAAAASgHVD--VVKYLLRNGAEIDEPNAFG 239
Cdd:PHA02859  128 H--MYMCNfnvrINVIKLLIDSGVSFLNKDFDNNNILYSYILF-HSDkkIFDFLTSLGIDINETNKSG 192
PHA02859 PHA02859
ankyrin repeat protein; Provisional
 416-494 1.28e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165195 [Multi-domain]  Cd Length: 209  Bit Score: 41.34  E-value: 1.28e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   416 INTPDNFGRTCLHAAASG--GNIECLNLLLSSGADMNKKDK-FGRTPLHYAAA---NGRYQCVVVLVGAGAEVNERDRSG 489
Cdd:PHA02859   44 VNDCNDLYETPIFSCLEKdkVNVEILKFLIENGADVNFKTRdNNLSALHHYLSfnkNVEPEILKILIDSGSSITEEDEDG 123


                  ....*
gi 66392221   490 CTPLH 494
Cdd:PHA02859  124 KNLLH 128
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 456-487 1.55e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 36.88  E-value: 1.55e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 66392221    456 GRTPLHYAAA-NGRYQCVVVLVGAGAEVNERDR 487
Cdd:pfam00023    2 GNTPLHLAAGrRGNLEIVKLLLSKGADVNARDK 34
TRPV1-4 cd22193
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 1-4; TRPV1-4 are ...
 76-237 1.72e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 1-4; TRPV1-4 are thermo-sensing channels that function directly in temperature-sensing and nociception; they share substantial structural and functional properties. Transient Receptor Potential (TRP) ion channels activated by temperature (thermo TRPs) are important molecular players in acute, inflammatory, and chronic pain states. So far, 11 TRP channels in mammalian cells have been identified as thermosensitive TRP (thermo-TRP) channels. TRPV1-4 channels are activated by different heat temperatures, for example, TRPV1 and TRPV2 are activated by high temperatures (>43C and >55C, respectively). TRPV1-4 belong to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411977 [Multi-domain]  Cd Length: 607  Bit Score: 42.48  E-value: 1.72e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   76 TPLHRAAASRNERAVGLLLRKGADVTARDK--------------YWQTPLHIAAANRATRCVETLL--PHV-SSLNMADR 138
Cdd:cd22193   78 TALHIAIERRQGDIVALLVENGADVHAHAKgrffqpkyqgegfyFGELPLSLAACTNQPDIVQYLLenEHQpADIEAQDS 157

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221  139 TGRAPLH--------HAAQSGY-QEMVKLLLNKGANLSASDKkdrqpihwaaylghLEVVKllvsqgsdksckDKRGYTP 209
Cdd:cd22193  158 RGNTVLHalvtvadnTKENTKFvTRMYDMILIRGAKLCPTVE--------------LEEIR------------NNDGLTP 211

                        170       180
                 ....*....|....*....|....*...
gi 66392221  210 LHAAAASGHVDVVKYLLRNgaEIDEPNA 237
Cdd:cd22193  212 LQLAAKMGKIEILKYILQR--EIKEPEL 237
Ank_4 pfam13637
Ankyrin repeats (many copies);
748-805 1.76e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 37.64  E-value: 1.76e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 66392221    748 GRSALHLAASCGHADILSNLLSaadhSQPQDPLTDRHGYTPAHWAAYHGHEDCLEVLL 805
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLE----KGADINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_4 pfam13637
Ankyrin repeats (many copies);
612-666 1.78e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 37.64  E-value: 1.78e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 66392221    612 GRSVLYLASQRGHSRCVELLLSQSASCLLAEhRSKWGPLHVAAANGHSECLRMLL 666
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVD-GNGETALHFAASNGNVEVLKLLL 54
PHA02736 PHA02736
Viral ankyrin protein; Provisional
 423-470 1.90e-03

Viral ankyrin protein; Provisional


Pssm-ID: 165103 [Multi-domain]  Cd Length: 154  Bit Score: 39.86  E-value: 1.90e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 66392221   423 GRTCLHAAASGGNI---ECLNLLLSSGADMNKKD-KFGRTPLHYAAANGRYQ 470
Cdd:PHA02736   55 GKQCVHIVSNPDKAdpqEKLKLLMEWGADINGKErVFGNTPLHIAVYTQNYE 106
PHA02946 PHA02946
ankyin-like protein; Provisional
 546-772 1.93e-03

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 41.96  E-value: 1.93e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   546 SAVHYAAAHG--NKQNLELLLEMcfntLGDKESNGSISPLH--LAVESGHWECVTVLIESGVCVDVCDPVGRSVLYLASQ 621
Cdd:PHA02946    6 SAEYYLSLYAkyNSKNLDVFRNM----LQAIEPSGNYHILHayCGIKGLDERFVEELLHRGYSPNETDDDGNYPLHIASK 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   622 RGHSRCVELLLSQSASCLLAEHRSKwGPLHVAAANGHSECLRMLLCSEGGADLVNVTDAEGQTPLmLAVLGGHTDCVHLL 701
Cdd:PHA02946   82 INNNRIVAMLLTHGADPNACDKQHK-TPLYYLSGTDDEVIERINLLVQYGAKINNSVDEEGCGPL-LACTDPSERVFKKI 159

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 66392221   702 LERGACPDMKDRRGRTALHRGAVMG--REDCLTALLSHNVSVLSRDFQGRSALHLAAS--CGHADILSNLLSAAD 772
Cdd:PHA02946  160 MSIGFEARIVDKFGKNHIHRHLMSDnpKASTISWMMKLGISPSKPDHDGNTPLHIVCSktVKNVDIINLLLPSTD 234
Ank_5 pfam13857
Ankyrin repeats (many copies);
649-689 2.06e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 37.33  E-value: 2.06e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 66392221    649 PLHVAAANGHSECLRMLLcsEGGADLvNVTDAEGQTPLMLA 689
Cdd:pfam13857   19 PLHVAAKYGALEIVRVLL--AYGVDL-NLKDEEGLTALDLA 56
Ank_4 pfam13637
Ankyrin repeats (many copies);
520-564 2.10e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 37.25  E-value: 2.10e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 66392221    520 EKESFLCVEHLLDNGADPCLCNTKGYSAVHYAAAHGNKQNLELLL 564
Cdd:pfam13637   10 ASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02741 PHA02741
hypothetical protein; Provisional
 202-325 2.27e-03

hypothetical protein; Provisional


Pssm-ID: 165108 [Multi-domain]  Cd Length: 169  Bit Score: 40.03  E-value: 2.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   202 KDKRGYTPLHAAAASGHVDVVK----YLLRN--GAEIDEPNAFGNTALHVACYTGQEAVANE----LVNRGANVN-QPNH 270
Cdd:PHA02741   17 KNSEGENFFHEAARCGCFDIIArftpFIRGDchAAALNATDDAGQMCIHIAAEKHEAQLAAEiidhLIELGADINaQEML 96

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 66392221   271 RGYTPLHLAAVSTNGALCLELLVNNGADVNMQSKEGKSPLHMAAIHGRFTRSQIL 325
Cdd:PHA02741   97 EGDTALHLAAHRRDHDLAEWLCCQPGIDLHFCNADNKSPFELAIDNEDVAMMQIL 151
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 681-710 2.57e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.41  E-value: 2.57e-03
                            10        20        30
                    ....*....|....*....|....*....|
gi 66392221     681 EGQTPLMLAVLGGHTDCVHLLLERGACPDM 710
Cdd:smart00248    1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
TRPV3 cd22194
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a ...
 682-769 2.67e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a temperature-sensitive Transient Receptor Potential (TRP) ion channel that is activated by warm temperatures, synthetic small-molecule chemicals, and natural compounds from plants. TRPV3 function is regulated by physiological factors such as extracellular divalent cations and acidic pH, intracellular adenosine triphosphate, membrane voltage, and arachidonic acid. It is expressed in both neuronal and non-neuronal tissues including epidermal keratinocytes, epithelial cells in the gut, endothelial cells in blood vessels, and neurons in dorsal root ganglia and CNS. TRPV3 null mice have abnormal hair morphogenesis and compromised skin barrier function. It may play roles in inflammatory skin disorders, such as itch and pain sensation. TRPV3 is also expressed by many neuronal and non-neuronal tissues, showing that TRPV3 might play roles in other unknown cellular and physiological functions. TRPV3 belongs to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411978 [Multi-domain]  Cd Length: 680  Bit Score: 41.67  E-value: 2.67e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221  682 GQTPLMLAVLGGHTDCVHLLLERGACP-DMKDRRGRTALHrGAVMGREDCLTA-----------LLSHNVSVLS--RDFQ 747
Cdd:cd22194  188 GETPLALAACTNQPEIVQLLMEKESTDiTSQDSRGNTVLH-ALVTVAEDSKTQndfvkrmydmiLLKSENKNLEtiRNNE 266

                         90       100
                 ....*....|....*....|..
gi 66392221  748 GRSALHLAASCGHADILSNLLS 769
Cdd:cd22194  267 GLTPLQLAAKMGKAEILKYILS 288
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 140-168 2.68e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.41  E-value: 2.68e-03
                            10        20
                    ....*....|....*....|....*....
gi 66392221     140 GRAPLHHAAQSGYQEMVKLLLNKGANLSA 168
Cdd:smart00248    2 GRTPLHLAAENGNLEVVKLLLDKGADINA 30
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 42-69 2.92e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.03  E-value: 2.92e-03
                            10        20
                    ....*....|....*....|....*...
gi 66392221      42 RTPLHAAAWLGDVHIMDLLISAGANVNA 69
Cdd:smart00248    3 RTPLHLAAENGNLEVVKLLLDKGADINA 30
Ank_4 pfam13637
Ankyrin repeats (many copies);
819-873 3.83e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 36.48  E-value: 3.83e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 66392221    819 TPLHCALINGHSGSAELLLESSVCnslVNIRDAKGRTPLHAAAVAEDVAGLQLVL 873
Cdd:pfam13637    3 TALHAAAASGHLELLRLLLEKGAD---INAVDGNGETALHFAASNGNVEVLKLLL 54
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 957-992 4.52e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 41.04  E-value: 4.52e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 66392221   957 QMPLHIAARNGLATVVQALLNRGATVLAVDEEGHTP 992
Cdd:PTZ00322  116 RTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTP 151
PHA02736 PHA02736
Viral ankyrin protein; Provisional
 203-297 4.53e-03

Viral ankyrin protein; Provisional


Pssm-ID: 165103 [Multi-domain]  Cd Length: 154  Bit Score: 39.09  E-value: 4.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   203 DKRGYTPLHAAAASGHVD---VVKYLLRNGAEID-EPNAFGNTALHVACYTGQEAVANELVNR-GANVNQPNHRGYTPLH 277
Cdd:PHA02736   52 NRHGKQCVHIVSNPDKADpqeKLKLLMEWGADINgKERVFGNTPLHIAVYTQNYELATWLCNQpGVNMEILNYAFKTPYY 131

                          90       100
                  ....*....|....*....|
gi 66392221   278 LAAvSTNGALCLELLVNNGA 297
Cdd:PHA02736  132 VAC-ERHDAKMMNILRAKGA 150
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 846-992 4.60e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 40.72  E-value: 4.60e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   846 VNIRDAKGRTPLHAAAVAEDVAGLQLVLRQGADIDAVDHSGRSALMVAADYGQSGAVALLLHRAkADLSLL---DVNKNT 922
Cdd:PHA02874   28 INISVDETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIDNG-VDTSILpipCIEKDM 106

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221   923 alhlacskahemcamlILKEIHNPILINATNSMLQMPLHIAARNGLATVVQALLNRGATVLAVDEEGHTP 992
Cdd:PHA02874  107 ----------------IKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYP 160
TRPV3 cd22194
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a ...
 852-978 4.81e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a temperature-sensitive Transient Receptor Potential (TRP) ion channel that is activated by warm temperatures, synthetic small-molecule chemicals, and natural compounds from plants. TRPV3 function is regulated by physiological factors such as extracellular divalent cations and acidic pH, intracellular adenosine triphosphate, membrane voltage, and arachidonic acid. It is expressed in both neuronal and non-neuronal tissues including epidermal keratinocytes, epithelial cells in the gut, endothelial cells in blood vessels, and neurons in dorsal root ganglia and CNS. TRPV3 null mice have abnormal hair morphogenesis and compromised skin barrier function. It may play roles in inflammatory skin disorders, such as itch and pain sensation. TRPV3 is also expressed by many neuronal and non-neuronal tissues, showing that TRPV3 might play roles in other unknown cellular and physiological functions. TRPV3 belongs to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411978 [Multi-domain]  Cd Length: 680  Bit Score: 40.90  E-value: 4.81e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221  852 KGRTPLHAAAVAEDVAGLQLVLRQGADIDAVD--------------HSGRSALMVAADYGQSGAVALLLHRAKADLSLLD 917
Cdd:cd22194  140 EGQTALNIAIERRQGDIVKLLIAKGADVNAHAkgvffnpkykhegfYFGETPLALAACTNQPEIVQLLMEKESTDITSQD 219

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221  918 VNKNTALHLACSKAHEMCAML-ILKEIHNPILINATNSMLQ--------MPLHIAARNGLATVVQALLNR 978
Cdd:cd22194  220 SRGNTVLHALVTVAEDSKTQNdFVKRMYDMILLKSENKNLEtirnneglTPLQLAAKMGKAEILKYILSR 289
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 239-270 4.91e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 35.73  E-value: 4.91e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 66392221    239 GNTALHVACY-TGQEAVANELVNRGANVNQPNH 270
Cdd:pfam00023    2 GNTPLHLAAGrRGNLEIVKLLLSKGADVNARDK 34
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 43-160 5.19e-03

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 40.83  E-value: 5.19e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221     43 TPLHAAAWLGDVHIMDLLISAGANVNAK---------DHVWL-----TPLHRAAASRNERAVGLLLRKGADVTARDKYWQ 108
Cdd:TIGR00870  130 TALHLAAHRQNYEIVKLLLERGASVPARacgdffvksQGVDSfyhgeSPLNAAACLGSPSIVALLSEDPADILTADSLGN 209

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 66392221    109 TPLHIA-------AANRATRC-----VETLLPHVSSLN----MADRTGRAPLHHAAQSGYQEMVKLLL 160
Cdd:TIGR00870  210 TLLHLLvmenefkAEYEELSCqmynfALSLLDKLRDSKelevILNHQGLTPLKLAAKEGRIVLFRLKL 277
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 24-95 5.32e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 40.65  E-value: 5.32e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 66392221    24 VKLFLHKKDEVNALDQERRTPLHAAAWLGDVHIMDLLISAGANVNAKDHVWLTPLHRAAASRNERAVGLLLR 95
Cdd:PTZ00322   98 ARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSR 169
Ank_2 pfam12796
Ankyrin repeats (3 copies);
960-1013 5.62e-03

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 37.02  E-value: 5.62e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 66392221    960 LHIAARNGLATVVQALLNRGATVLAVDEEGHTPALACASNKaVADCLALILSTM 1013
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNG-HLEIVKLLLEHA 53
Ank_4 pfam13637
Ankyrin repeats (many copies);
921-976 6.59e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 35.71  E-value: 6.59e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 66392221    921 NTALHLACSKAHEMCAMLILKeihNPILINATNSMLQMPLHIAARNGLATVVQALL 976
Cdd:pfam13637    2 LTALHAAAASGHLELLRLLLE---KGADINAVDGNGETALHFAASNGNVEVLKLLL 54
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 784-809 6.62e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 35.26  E-value: 6.62e-03
                            10        20
                    ....*....|....*....|....*.
gi 66392221     784 HGYTPAHWAAYHGHEDCLEVLLELKP 809
Cdd:smart00248    1 DGRTPLHLAAENGNLEVVKLLLDKGA 26
Ank_4 pfam13637
Ankyrin repeats (many copies);
10-61 7.13e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 35.71  E-value: 7.13e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 66392221     10 PPLVQAIFNRNADEVKLFLHKKDEVNALDQERRTPLHAAAWLGDVHIMDLLI 61
Cdd:pfam13637    3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 781-927 7.48e-03

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 40.45  E-value: 7.48e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221    781 TDRHGYTPAHWAAYHGHEDCLEVLLELKPCSIQEGNpfTPLHCALINGHSGSAELLL------ESSVCNSLVNIRDA--- 851
Cdd:TIGR00870   48 PDRLGRSALFVAAIENENLELTELLLNLSCRGAVGD--TLLHAISLEYVDAVEAILLhllaafRKSGPLELANDQYTsef 125

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392221    852 -KGRTPLHAAAVAEDVAGLQLVLRQGADIDA-------VDHS-------GRSALMVAADYGQSGAVALLLhRAKADLSLL 916
Cdd:TIGR00870  126 tPGITALHLAAHRQNYEIVKLLLERGASVPAracgdffVKSQgvdsfyhGESPLNAAACLGSPSIVALLS-EDPADILTA 204

                          170
                   ....*....|.
gi 66392221    917 DVNKNTALHLA 927
Cdd:TIGR00870  205 DSLGNTLLHLL 215
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 338-364 7.59e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 34.87  E-value: 7.59e-03
                            10        20
                    ....*....|....*....|....*..
gi 66392221     338 YGNTPLHVAAKYGHELLISTLMTNGAD 364
Cdd:smart00248    1 DGRTPLHLAAENGNLEVVKLLLDKGAD 27
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 530-604 8.14e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 40.27  E-value: 8.14e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 66392221   530 LLDNGADPCLCNTKGYSAVHYAAAHGNKQNLELLLEMCFN-TLGDKESNgsiSPLHLAVESGHWECVTVLIESGVC 604
Cdd:PTZ00322  101 LLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADpTLLDKDGK---TPLELAEENGFREVVQLLSRHSQC 173
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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