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Conserved domains on  [gi|62912474|ref|NP_001017404|]
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leucine-rich repeat-containing G-protein coupled receptor 6 isoform 3 [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein; leucine-rich repeat and calponin homology domain-containing protein( domain architecture ID 11469450)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions| leucine-rich repeat and calponin homology (LRCH) domain-containing protein similar to human LRCH4 which is a Toll-like receptor (TLR) accessory protein that regulates signaling by multiple TLRs

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
7tmA_LGR6 cd15362
leucine-rich repeats-containing G protein-coupled receptor 6, the class A of 7-transmembrane ...
 423-695 6.98e-165

leucine-rich repeats-containing G protein-coupled receptor 6, the class A of 7-transmembrane GPCRs; The leucine-rich repeat containing G-protein coupled receptor LGR5, together with its family members LGR4 and LGR6, is structurally related to the glycoprotein hormone receptor family, which includes the luteinizing hormone (LH) receptor, the follicle-stimulating hormone (FSH) receptor, and the pituitary thyroid-stimulating hormone (TSH) receptor. LGR4-6 are receptors for the R-spondin (Rspo) family of secreted proteins containing two N-terminal furin-like repeats and a thrombospondin domain. The Rspo proteins are involved in regulating proliferation and differentiation of adult stem cells by potently enhancing the WNT-stimulated beta-catenin signaling. LGR5 serves as a marker for resident stem cell in numerous epithelial cell layers, including small intestine, colon, stomach, and kidney. LGR6 is a marker for multipotent stem cells in the hair follicle that generate all skin cell lineages. In addition, LGR4 is broadly expressed in proliferating cells, and its deficient mice display development defects in multiple organs. Members of this group are characterized by a very large extracellular N-terminal domain containing 17 leucine-rich repeats (LRRs), flanked by cysteine-rich N- and C-terminal capping domains, and the extracellular domain is responsible for high-affinity binding with the Rspo proteins.


:

Pssm-ID: 320484  Cd Length: 276  Bit Score: 478.90  E-value: 6.98e-165
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912474 423 WGIRLAVWAIVLLSVLCNGLVLLTVFAGGPVpLPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLG 502
Cdd:cd15362   1 WVVRLGVWAIVLVSVLCNGLVILTVFASPGY-LSPVKFVIGSIAGANLLTGICTGTLALVDALTFGQFAKYGARWETGLG 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912474 503 CRATGFLAVLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASVGEYGASPLCLPYA 582
Cdd:cd15362  80 CRATGFLSVFASEASILLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAAALCCLALSLTAAALPLFSVGEYGASPLCLPSP 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912474 583 PPEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEAVWDCAMVRHVAWLIFADGLLYCPVAFLSFASMLGLF 662
Cdd:cd15362 160 LPDGKPSTLGFTVALIMMNTLCFLVITGTYIKLYCDLLKGEFDAIWDCAMIKHVAWLIFTNCLLYCPVAFLTFSSLLNLF 239

                       250       260       270
                ....*....|....*....|....*....|...
gi 62912474 663 PVTPEAVKSVLLVVLPLPACLNPLLYLLFNPHF 695
Cdd:cd15362 240 PISPEVIKSVLLVVLPLPACLNPLLYLLFNPHF 272
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
46-326 2.76e-33

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 133.14  E-value: 2.76e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912474  46 LRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNqlggipaEALWELPSLQSLDLNYNKLQEFPVAIRTLGRLQELGF 125
Cdd:COG4886  71 LLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDL 143

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912474 126 HNNNIKAIPEkAFMGNPLLQTIHFYDNPIQFVGrSAFQYLPKLHTLSLNGAmDIQEFPD-LKGTTSLEILTLTRAGIRLL 204
Cdd:COG4886 144 SNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLP-EELGNLTNLKELDLSNN-QITDLPEpLGNLTNLEELDLSGNQLTDL 220

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912474 205 PSGMcQQLPRLRVLELSHNQIEELPSLHRCQKLEEIGLQHNRIWEIgaDTFSQLSSLQALDLSWNAIRSIHPEAFSTLHS 284
Cdd:COG4886 221 PEPL-ANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDL--PPLANLTNLKTLDLSNNQLTDLKLKELELLLG 297

                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 62912474 285 LVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAFSKDSF 326
Cdd:COG4886 298 LNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTT 339
 
Name Accession Description Interval E-value
7tmA_LGR6 cd15362
leucine-rich repeats-containing G protein-coupled receptor 6, the class A of 7-transmembrane ...
 423-695 6.98e-165

leucine-rich repeats-containing G protein-coupled receptor 6, the class A of 7-transmembrane GPCRs; The leucine-rich repeat containing G-protein coupled receptor LGR5, together with its family members LGR4 and LGR6, is structurally related to the glycoprotein hormone receptor family, which includes the luteinizing hormone (LH) receptor, the follicle-stimulating hormone (FSH) receptor, and the pituitary thyroid-stimulating hormone (TSH) receptor. LGR4-6 are receptors for the R-spondin (Rspo) family of secreted proteins containing two N-terminal furin-like repeats and a thrombospondin domain. The Rspo proteins are involved in regulating proliferation and differentiation of adult stem cells by potently enhancing the WNT-stimulated beta-catenin signaling. LGR5 serves as a marker for resident stem cell in numerous epithelial cell layers, including small intestine, colon, stomach, and kidney. LGR6 is a marker for multipotent stem cells in the hair follicle that generate all skin cell lineages. In addition, LGR4 is broadly expressed in proliferating cells, and its deficient mice display development defects in multiple organs. Members of this group are characterized by a very large extracellular N-terminal domain containing 17 leucine-rich repeats (LRRs), flanked by cysteine-rich N- and C-terminal capping domains, and the extracellular domain is responsible for high-affinity binding with the Rspo proteins.


Pssm-ID: 320484  Cd Length: 276  Bit Score: 478.90  E-value: 6.98e-165
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912474 423 WGIRLAVWAIVLLSVLCNGLVLLTVFAGGPVpLPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLG 502
Cdd:cd15362   1 WVVRLGVWAIVLVSVLCNGLVILTVFASPGY-LSPVKFVIGSIAGANLLTGICTGTLALVDALTFGQFAKYGARWETGLG 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912474 503 CRATGFLAVLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASVGEYGASPLCLPYA 582
Cdd:cd15362  80 CRATGFLSVFASEASILLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAAALCCLALSLTAAALPLFSVGEYGASPLCLPSP 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912474 583 PPEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEAVWDCAMVRHVAWLIFADGLLYCPVAFLSFASMLGLF 662
Cdd:cd15362 160 LPDGKPSTLGFTVALIMMNTLCFLVITGTYIKLYCDLLKGEFDAIWDCAMIKHVAWLIFTNCLLYCPVAFLTFSSLLNLF 239

                       250       260       270
                ....*....|....*....|....*....|...
gi 62912474 663 PVTPEAVKSVLLVVLPLPACLNPLLYLLFNPHF 695
Cdd:cd15362 240 PISPEVIKSVLLVVLPLPACLNPLLYLLFNPHF 272
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
46-326 2.76e-33

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 133.14  E-value: 2.76e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912474  46 LRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNqlggipaEALWELPSLQSLDLNYNKLQEFPVAIRTLGRLQELGF 125
Cdd:COG4886  71 LLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDL 143

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912474 126 HNNNIKAIPEkAFMGNPLLQTIHFYDNPIQFVGrSAFQYLPKLHTLSLNGAmDIQEFPD-LKGTTSLEILTLTRAGIRLL 204
Cdd:COG4886 144 SNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLP-EELGNLTNLKELDLSNN-QITDLPEpLGNLTNLEELDLSGNQLTDL 220

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912474 205 PSGMcQQLPRLRVLELSHNQIEELPSLHRCQKLEEIGLQHNRIWEIgaDTFSQLSSLQALDLSWNAIRSIHPEAFSTLHS 284
Cdd:COG4886 221 PEPL-ANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDL--PPLANLTNLKTLDLSNNQLTDLKLKELELLLG 297

                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 62912474 285 LVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAFSKDSF 326
Cdd:COG4886 298 LNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTT 339
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 29-302 1.76e-17

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 87.60  E-value: 1.76e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912474   29 DLSMNNLTELQPGLFHHLRFLEELRLSGNHLS-HIPGqAFSGLYSLKILMLQNNQL-GGIPAEaLWELPSLQSLDLNYNK 106
Cdd:PLN00113 290 DLSDNSLSGEIPELVIQLQNLEILHLFSNNFTgKIPV-ALTSLPRLQVLQLWSNKFsGEIPKN-LGKHNNLTVLDLSTNN 367

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912474  107 LQ-------------------------EFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSA 161
Cdd:PLN00113 368 LTgeipeglcssgnlfklilfsnslegEIPKSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQGRINSR 447

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912474  162 FQYLPKLHTLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIR-LLPSGMcQQLPRLRVLELSHNQIE-ELPS-LHRCQKLE 238
Cdd:PLN00113 448 KWDMPSLQMLSLARNKFFGGLPDSFGSKRLENLDLSRNQFSgAVPRKL-GSLSELMQLKLSENKLSgEIPDeLSSCKKLV 526

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 62912474  239 EIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQL-TTLPLAG 302
Cdd:PLN00113 527 SLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQLSGEIPKNLGNVESLVQVNISHNHLhGSLPSTG 591
LRR_8 pfam13855
Leucine rich repeat;
49-107 5.12e-15

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 69.86  E-value: 5.12e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 62912474    49 LEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLDLNYNKL 107
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 167-314 4.40e-14

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 72.13  E-value: 4.40e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912474 167 KLHTLSLNGaMDIQEFPDLKGTTSLEILTLTRAGIRLLPSgmCQQLPRLRVLELSHNQIEELPSLHRCQKLEEIGLQHNR 246
Cdd:cd21340   3 RITHLYLND-KNITKIDNLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNR 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912474 247 IWEI-GADTFSQLS---------------------------SLQALDLSWNAIRSIHPeaFSTLHSLVKLDLTDNQLT-- 296
Cdd:cd21340  80 ISVVeGLENLTNLEelhienqrlppgekltfdprslaalsnSLRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQISdl 157

                       170       180
                ....*....|....*....|.
gi 62912474 297 ---TLPLAGLGGLMHLKLKGN 314
Cdd:cd21340 158 eelLDLLSSWPSLRELDLTGN 178
LRR smart00370
Leucine-rich repeats, outliers;
258-280 3.88e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 35.41  E-value: 3.88e-03
                           10        20
                   ....*....|....*....|...
gi 62912474    258 LSSLQALDLSWNAIRSIHPEAFS 280
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQ 23
 
Name Accession Description Interval E-value
7tmA_LGR6 cd15362
leucine-rich repeats-containing G protein-coupled receptor 6, the class A of 7-transmembrane ...
 423-695 6.98e-165

leucine-rich repeats-containing G protein-coupled receptor 6, the class A of 7-transmembrane GPCRs; The leucine-rich repeat containing G-protein coupled receptor LGR5, together with its family members LGR4 and LGR6, is structurally related to the glycoprotein hormone receptor family, which includes the luteinizing hormone (LH) receptor, the follicle-stimulating hormone (FSH) receptor, and the pituitary thyroid-stimulating hormone (TSH) receptor. LGR4-6 are receptors for the R-spondin (Rspo) family of secreted proteins containing two N-terminal furin-like repeats and a thrombospondin domain. The Rspo proteins are involved in regulating proliferation and differentiation of adult stem cells by potently enhancing the WNT-stimulated beta-catenin signaling. LGR5 serves as a marker for resident stem cell in numerous epithelial cell layers, including small intestine, colon, stomach, and kidney. LGR6 is a marker for multipotent stem cells in the hair follicle that generate all skin cell lineages. In addition, LGR4 is broadly expressed in proliferating cells, and its deficient mice display development defects in multiple organs. Members of this group are characterized by a very large extracellular N-terminal domain containing 17 leucine-rich repeats (LRRs), flanked by cysteine-rich N- and C-terminal capping domains, and the extracellular domain is responsible for high-affinity binding with the Rspo proteins.


Pssm-ID: 320484  Cd Length: 276  Bit Score: 478.90  E-value: 6.98e-165
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912474 423 WGIRLAVWAIVLLSVLCNGLVLLTVFAGGPVpLPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLG 502
Cdd:cd15362   1 WVVRLGVWAIVLVSVLCNGLVILTVFASPGY-LSPVKFVIGSIAGANLLTGICTGTLALVDALTFGQFAKYGARWETGLG 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912474 503 CRATGFLAVLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASVGEYGASPLCLPYA 582
Cdd:cd15362  80 CRATGFLSVFASEASILLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAAALCCLALSLTAAALPLFSVGEYGASPLCLPSP 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912474 583 PPEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEAVWDCAMVRHVAWLIFADGLLYCPVAFLSFASMLGLF 662
Cdd:cd15362 160 LPDGKPSTLGFTVALIMMNTLCFLVITGTYIKLYCDLLKGEFDAIWDCAMIKHVAWLIFTNCLLYCPVAFLTFSSLLNLF 239

                       250       260       270
                ....*....|....*....|....*....|...
gi 62912474 663 PVTPEAVKSVLLVVLPLPACLNPLLYLLFNPHF 695
Cdd:cd15362 240 PISPEVIKSVLLVVLPLPACLNPLLYLLFNPHF 272
7tmA_LRR_GPR cd15138
orphan leucine-rich repeat-containing G protein-coupled receptors, member of the class A ...
 423-695 5.29e-147

orphan leucine-rich repeat-containing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes leucine-rich repeat-containing G-protein coupled receptor 4 (LGR4), 5 (LGR5), and 6 (LGR6). These receptors contain a subfamily of receptors related to the glycoprotein hormone receptor family, which includes the luteinizing hormone (LH) receptor, the follicle-stimulating hormone (FSH) receptor, and the pituitary thyroid-stimulating hormone (TSH) receptor. LGR4-6 are receptors for the R-spondin (Rspo) family of secreted proteins containing two N-terminal furin-like repeats and a thrombospondin domain. The RSPO proteins are involved in regulating proliferation and differentiation of adult stem cells by potently enhancing the WNT-stimulated beta-catenin signaling. LGR4 is broadly expressed in proliferating cells, and its deficient mice display development defects in multiple organs. LGR5 acts as a marker for resident stem cell in numerous epithelial cell layers, including small intestine, colon, stomach, and kidney. LGR6 also serves as a marker of multipotent stem cells in the hair follicle that generate all skin cell lineages. Members of this group are characterized by a very large extracellular N-terminal domain containing 17 leucine-rich repeats (LRRs), flanked by cysteine-rich N- and C-terminal capping domains, and the extracellular domain is responsible for high-affinity binding with the Rspo proteins.


Pssm-ID: 320266  Cd Length: 274  Bit Score: 433.13  E-value: 5.29e-147
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912474 423 WGIRLAVWAIVLLSVLCNGLVLLTVFAGGPVPlPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLG 502
Cdd:cd15138   1 WMIRLTVWFIFLLALFCNLLVILTVFASCTSL-PPSKLFIGLIAVSNLLTGISTGILAFVDAVTFGRFAEFGAWWETGSG 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912474 503 CRATGFLAVLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASVGEYGASPLCLPYA 582
Cdd:cd15138  80 CKVAGFLAVFSSESSVFLLTLAAVERSLSVKDIMKNGKSNHLKSFRVAALLCFLLATVAAAFPLFHRGEYGASPLCLPFP 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912474 583 PpeGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEAVWDCAMVRHVAWLIFADGLLYCPVAFLSFASMLGLF 662
Cdd:cd15138 160 T--GEPPSLGFTVALVLLNSLCFLLMAVAYTKLYCNLEKGDLEENWDCSMVKHVAWLIFTNCILFCPVAFLSFASLITLI 237

                       250       260       270
                ....*....|....*....|....*....|...
gi 62912474 663 PVTPEAVKSVLLVVLPLPACLNPLLYLLFNPHF 695
Cdd:cd15138 238 SISPEIMKSVLLVVFPLPACLNPLLYVLFNPHF 270
7tmA_LGR5 cd15363
leucine-rich repeats-containing G protein-coupled receptor 5, member of the class A family of ...
 423-695 2.74e-96

leucine-rich repeats-containing G protein-coupled receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The leucine-rich repeat containing G-protein coupled receptor LGR6, together with its family members LGR4 and LGR5, is structurally related to the glycoprotein hormone receptor family, which includes the luteinizing hormone (LH) receptor, the follicle-stimulating hormone (FSH) receptor, and the pituitary thyroid-stimulating hormone (TSH) receptor. LGR4-6 are receptors for the R-spondin (Rspo) family of secreted proteins containing two N-terminal furin-like repeats and a thrombospondin domain. The Rspo proteins are involved in regulating proliferation and differentiation of adult stem cells by potently enhancing the WNT-stimulated beta-catenin signaling. LGR6 serves as a marker of multipotent stem cells in the hair follicle that generate all skin cell lineages, whereas LGR5 is a marker for resident stem cell in numerous epithelial cell layers, including small intestine, colon, stomach, and kidney. In addition, LGR4 is broadly expressed in proliferating cells, and its deficient mice display development defects in multiple organs. Members of this group are characterized by a very large extracellular N-terminal domain containing 17 leucine-rich repeats (LRRs), flanked by cysteine-rich N- and C-terminal capping domains, and the extracellular domain is responsible for high-affinity binding with the Rspo proteins.


Pssm-ID: 320485  Cd Length: 274  Bit Score: 301.76  E-value: 2.74e-96
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912474 423 WGIRLAVWAIVLLSVLCNGLVLLTVFAGgPVPLPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLG 502
Cdd:cd15363   1 WLIRIGVWTIAVLALVCNALVTATVFRS-PLYISSIKLLIGLIAIVNMLMGVSSAVLAGVDAFTFGSFAQHGAWWESGVG 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912474 503 CRATGFLAVLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASVGEYGASPLCLPYa 582
Cdd:cd15363  80 CQITGFLSIFASESSVFLLTLAALERGFSVKCSTKFETKSPFLSLKAIILLCFLLALTIAVIPLLGGSEYGASPLCLPL- 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912474 583 pPEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEAVWDCAMVRHVAWLIFADGLLYCPVAFLSFASMLGLF 662
Cdd:cd15363 159 -PFGEPSAMGYMVALVLLNSLCFLVMTIAYTKLYCSLEKGELENIWDCSMVKHIALLLFTNCILYCPVAFLSFSSLLNLT 237

                       250       260       270
                ....*....|....*....|....*....|...
gi 62912474 663 PVTPEAVKSVLLVVLPLPACLNPLLYLLFNPHF 695
Cdd:cd15363 238 FISPEVIKFILLVIVPLPACLNPLLYILFNPHF 270
7tmA_LGR4 cd15361
leucine-rich repeats-containing G protein-coupled receptor 4, member of the class A family of ...
 423-695 3.82e-76

leucine-rich repeats-containing G protein-coupled receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The leucine-rich repeat containing G-protein coupled receptor Lgr4 (formerly known as Gpr48), together with its close family members LGR5 and LGR6, is structurally related to the glycoprotein hormone receptor family, which includes the luteinizing hormone (LH) receptor, the follicle-stimulating hormone (FSH) receptor, and the pituitary thyroid-stimulating hormone (TSH) receptor. LGR4-6 are receptors for the R-spondin (Rspo) family of secreted proteins containing two N-terminal furin-like repeats and a thrombospondin domain. The Rspo proteins are involved in regulating proliferation and differentiation of adult stem cells by potently enhancing the WNT-stimulated beta-catenin signaling. LGR4 is broadly expressed in proliferating cells, and its deficient mice display development defects in multiple organs. LGR5 acts as a marker for resident stem cell in numerous epithelial cell layers, including small intestine, colon, stomach, and kidney. LGR6 also serves as a marker of multipotent stem cells in the hair follicle that generate all skin cell lineages. Members of this group are characterized by a very large extracellular N-terminal domain containing 17 leucine-rich repeats (LRRs), flanked by cysteine-rich N- and C-terminal capping domains, and the extracellular domain is responsible for high-affinity binding with the Rspo proteins.


Pssm-ID: 320483  Cd Length: 274  Bit Score: 248.62  E-value: 3.82e-76
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912474 423 WGIRLAVWAIVLLSVLCNGLVLLTVFAGGpVPLPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLG 502
Cdd:cd15361   1 WMIRLTVWFIFLVALFFNLLVILTTFASC-TSLPSSKLFVGLIAVSNLFMGVYTGILTFLDTVSWGRFAEFGIWWETGSG 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912474 503 CRATGFLAVLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASVGEYGASPLCLPYa 582
Cdd:cd15361  80 CKVAGFLAVFSSESAIFLLMLAAVERSLSAKDIMKKGKSNRLRQFQIAALLAFLVATAAGCLPLFHGGEYSASPLCLPF- 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912474 583 pPEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEAVWDCAMVRHVAWLIFADGLLYCPVAFLSFASMLGLF 662
Cdd:cd15361 159 -PTGETPSLGFTVTLVLLNSLAFLLMAVIYTKLYCNLEKEDLSENSQSSMIKHVAWLIFTNCIFFCPVAFFSFAPLITAI 237

                       250       260       270
                ....*....|....*....|....*....|...
gi 62912474 663 PVTPEAVKSVLLVVLPLPACLNPLLYLLFNPHF 695
Cdd:cd15361 238 SISPEIMKSVTLIFFPLPACLNPVLYVFFNPKF 270
7tmA_Glycoprotein_LRR_R-like cd14980
glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, ...
 423-695 3.97e-39

glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the glycoprotein hormone receptors (GPHRs), vertebrate receptors containing 17 leucine-rich repeats (LGR4-6), and the relaxin family peptide receptors (also known as LGR7 and LGR8). They are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone receptor family contains receptors for the pituitary hormones, thyrotropin (thyroid-stimulating hormone receptor), follitropin (follicle-stimulating hormone receptor), and lutropin (luteinizing hormone receptor). Glycoprotein hormone receptors couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein. Two orphan GPCRs, LGR7 and LGR8, have been recently identified as receptors for the relaxin peptide hormones.


Pssm-ID: 320111 [Multi-domain]  Cd Length: 286  Bit Score: 146.62  E-value: 3.97e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912474 423 WGIRLAVWAIVLLSVLCNGLVLLTVF----AGGPVPlppvKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWE 498
Cdd:cd14980   1 ISLRIFIWIIGILALIGNILVIIWHIsskkKKKKVP----KLLIINLAIADFLMGIYLLIIAIADQYYRGRYAQYSEEWL 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912474 499 TGLGCRATGFLAVLGSEASVLLLTLAAVQ----CSVSVSCVRAYGKSP--------SLGSVRAGVLGCLalaglaaalpl 566
Cdd:cd14980  77 RSPPCLLACFLVSLSSLMSVLMMLLITLDryicIVYPFSNKRLSYKSAkiililgwLFSIIFAAIPILY----------- 145

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912474 567 aSVGE------YGASPLCLPYAPpeGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEAV-----WDCAMVRH 635
Cdd:cd14980 146 -SINQpgdnrlYGYSSICMPSNV--SNPYYRGWLIAYLLLTFIAWIIICILYILIFISVRKSRKSARrssskRDKRIAIR 222

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912474 636 VAWLIFADGLLYCPVAFLSFASMLGLFPVTPEAVKSVLLVVLPLPACLNPLLYLLFNPHF 695
Cdd:cd14980 223 LALILITDLICWLPYYIVIFSGLLTSTEIDIHVLQFIAILALPLNSAINPYLYTLTTPTF 282
7tmA_Glyco_hormone_R cd15136
glycoprotein hormone receptors, member of the class A family of seven-transmembrane G ...
 423-695 3.01e-36

glycoprotein hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors (GPHRs) are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG) and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. GPHRs couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein.


Pssm-ID: 320264 [Multi-domain]  Cd Length: 275  Bit Score: 138.12  E-value: 3.01e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912474 423 WGIRLAVWAIVLLSVLCNG---LVLLTVFAGGPVPlppvKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWET 499
Cdd:cd15136   1 WWLRIGVWFVFLLALVGNIivlLVLLTSRTKLTVP----RFLMCNLAFADFCMGIYLGLLAIVDAKTLGEYYNYAIDWQT 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912474 500 GLGCRATGFLAVLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASVGEYGASPLCL 579
Cdd:cd15136  77 GAGCKTAGFLAVFSSELSVFTLTVITLERWYAITHAMHLNKRLSLRQAAIIMLGGWIFALIMALLPLVGVSSYSKTSICL 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912474 580 PYAppEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEAVW-DCAMVRHVAWLIFADGLLYCPVAFLSFASM 658
Cdd:cd15136 157 PFE--TETPVSKAYVIFLLLFNGLAFLIICGCYIKIYLSVRGSGRAANSnDTRIAKRMALLVFTDFLCWAPIAFFGLTAA 234

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 62912474 659 LGLFPVTPEAVKSVLLVVLPLPACLNPLLYLLFNPHF 695
Cdd:cd15136 235 FGLPLISVSNAKILLVFFYPLNSCANPFLYAIFTKQF 271
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
46-326 2.76e-33

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 133.14  E-value: 2.76e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912474  46 LRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNqlggipaEALWELPSLQSLDLNYNKLQEFPVAIRTLGRLQELGF 125
Cdd:COG4886  71 LLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDL 143

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912474 126 HNNNIKAIPEkAFMGNPLLQTIHFYDNPIQFVGrSAFQYLPKLHTLSLNGAmDIQEFPD-LKGTTSLEILTLTRAGIRLL 204
Cdd:COG4886 144 SNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLP-EELGNLTNLKELDLSNN-QITDLPEpLGNLTNLEELDLSGNQLTDL 220

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912474 205 PSGMcQQLPRLRVLELSHNQIEELPSLHRCQKLEEIGLQHNRIWEIgaDTFSQLSSLQALDLSWNAIRSIHPEAFSTLHS 284
Cdd:COG4886 221 PEPL-ANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDL--PPLANLTNLKTLDLSNNQLTDLKLKELELLLG 297

                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 62912474 285 LVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAFSKDSF 326
Cdd:COG4886 298 LNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTT 339
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
33-300 1.81e-32

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 130.82  E-value: 1.81e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912474  33 NNLTELQPGLFHHLRFLEELRLSGNhlshipgQAFSGLYSLKILMLQNNQLGGIPAEaLWELPSLQSLDLNYNKLQEFPV 112
Cdd:COG4886  82 LSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLPEE-LANLTNLKELDLSNNQLTDLPE 153

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912474 113 AIRTLGRLQELGFHNNNIKAIPEkAFMGNPLLQTIHFYDNPIQFVGrSAFQYLPKLHTLSLNGaMDIQEFPD-LKGTTSL 191
Cdd:COG4886 154 PLGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDLP-EPLGNLTNLEELDLSG-NQLTDLPEpLANLTNL 230

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912474 192 EILTLTRAGIRLLPSgmCQQLPRLRVLELSHNQIEELPSLHRCQKLEEIGLQHNRI-----WEIGADTFSQLSSLQALDL 266
Cdd:COG4886 231 ETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLtdlklKELELLLGLNSLLLLLLLL 308

                       250       260       270
                ....*....|....*....|....*....|....
gi 62912474 267 SWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPL 300
Cdd:COG4886 309 NLLELLILLLLLTTLLLLLLLLKGLLVTLTTLAL 342
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
29-307 1.81e-28

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 118.88  E-value: 1.81e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912474  29 DLSMNNLTELqPGLFHHLRFLEELRLSGNHLSHIPgQAFSGLYSLKILMLQNNQLGGIPAEaLWELPSLQSLDLNYNKLQ 108
Cdd:COG4886 119 DLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDLPEE-LGNLTNLKELDLSNNQIT 195

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912474 109 EFPVAIRTLGRLQELGFHNNNIKAIPEkAFMGNPLLQTIHFYDNPIQFVgrSAFQYLPKLHTLSLNGaMDIQEFPDLKGT 188
Cdd:COG4886 196 DLPEPLGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDL--PELGNLTNLEELDLSN-NQLTDLPPLANL 271

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912474 189 TSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSW 268
Cdd:COG4886 272 TNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLT 351

                       250       260       270
                ....*....|....*....|....*....|....*....
gi 62912474 269 NAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGGLM 307
Cdd:COG4886 352 LLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLL 390
7tmA_TSH-R cd15964
thyroid-stimulating hormone receptor (or thyrotropin receptor), member of the class A family ...
 425-695 3.62e-26

thyroid-stimulating hormone receptor (or thyrotropin receptor), member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. TSH-R plays an important role thyroid physiology, and its activation stimulates the production of thyroxine (T4) and triiodothyronine (T3). Defects in TSH-R are a cause of several types of hyperthyroidism. The receptor is predominantly found on the surface of the thyroid epithelial cells and couples to the G(s)-protein and activates adenylate cyclase, thereby promoting cAMP production. TSH and cAMP stimulate thyroid cell proliferation, differentiation, and function.


Pssm-ID: 320630 [Multi-domain]  Cd Length: 275  Bit Score: 108.84  E-value: 3.62e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912474 425 IRLAVWAIVLLSVLCNGLVLLTVFAGGpVPLPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLGCR 504
Cdd:cd15964   3 LRIVVWFVNLLAILGNVFVLLILLTSH-YKLTVPRFLMCNLAFADFCMGIYLLLIASVDLHTRSEYYNHAIDWQTGPGCN 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912474 505 ATGFLAVLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASVGEYGASPLCLPYAPP 584
Cdd:cd15964  82 TAGFFTVFASELSVYTLTVITLERWYAITFAMRLDRKIRLRHASAIMLGGWVFCFLLALLPLVGVSSYAKVSICLPMDTE 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912474 585 egQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEA-VWDCAMVRHVAWLIFADGLLYCPVAFLSFASMLGLFP 663
Cdd:cd15964 162 --TPLAQAYIVFVLMLNIIAFVIICACYIKIYITVRNPQYKSgDKDTKIAKRMAVLIFTDFICMAPISFYALSAILNKPL 239

                       250       260       270
                ....*....|....*....|....*....|..
gi 62912474 664 VTPEAVKSVLLVVLPLPACLNPLLYLLFNPHF 695
Cdd:cd15964 240 ITVSNSKILLVLFYPLNSCANPFLYAIFTKAF 271
7tmA_FSH-R cd15360
follicle-stimulating hormone receptor, member of the class A family of seven-transmembrane G ...
 425-695 4.12e-23

follicle-stimulating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. FSH-R functions in gonad development and is found in the ovary, testis, and uterus. Defects in this receptor cause ovarian dysgenesis type 1, and also ovarian hyperstimulation syndrome. The FSH-R activation couples to the G(s)-protein and stimulates adenylate cyclase, thereby promoting cAMP production.


Pssm-ID: 320482  Cd Length: 275  Bit Score: 99.93  E-value: 4.12e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912474 425 IRLAVWAIVLLSVLCNgLVLLTVFAGGPVPLPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLGCR 504
Cdd:cd15360   3 LRVLIWFINILAITGN-IVVLAILLTSQYKLTVPRFLMCNLAFADLCMGIYLLLIASVDIRTKSQYYNYAIDWQTGAGCA 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912474 505 ATGFLAVLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASVGEYGASPLCLPYAPP 584
Cdd:cd15360  82 AAGFFTVFASELSVYTLTVITLERWHTITYAMQLDRKVRLRHAAVIMVGGWIFAFTVALLPIFGISSYMKVSICLPMDIE 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912474 585 egQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDF-EAVWDCAMVRHVAWLIFADGLLYCPVAFLSFASMLGLFP 663
Cdd:cd15360 162 --SPLSQAYIIFILVLNVLAFLIICACYIKIYLTVRNPNFvSSNSDTKIAKRMAVLIFTDFLCMAPISFFAISASLKVPL 239

                       250       260       270
                ....*....|....*....|....*....|..
gi 62912474 664 VTPEAVKSVLLVVLPLPACLNPLLYLLFNPHF 695
Cdd:cd15360 240 ITVSKSKILLVLFYPINSCANPFLYAIFTKTF 271
7tmA_LHCGR cd15359
luteinizing hormone-choriogonadotropin receptor, member of the class A family of ...
 425-695 2.08e-21

luteinizing hormone-choriogonadotropin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. LHCGR is expressed predominantly in the ovary and testis, and plays an essential role in sexual development and reproductive processes. LHCGR couples primarily to the G(s)-protein and activates adenylate cyclase, thereby promoting cAMP production.


Pssm-ID: 320481 [Multi-domain]  Cd Length: 275  Bit Score: 94.93  E-value: 2.08e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912474 425 IRLAVWAIVLLSVLCNGLVLLtVFAGGPVPLPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLGCR 504
Cdd:cd15359   3 LRVLIWFINILAIAGNLIVLF-VLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDSQTKSQYYNHAIDWQTGSGCS 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912474 505 ATGFLAVLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASVGEYGASPLCLPYAPP 584
Cdd:cd15359  82 TAGFFTVFASELSVYTLTVITLERWHTITYAMQLDRKLRLRHAILIMLGGWVFSLLIAVLPLVGVSNYMKVSICLPMDIE 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912474 585 EGQPAAlgFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEAV-WDCAMVRHVAWLIFADGLLYCPVAFLSFASMLGLFP 663
Cdd:cd15359 162 TLLSQA--YILLILVLNVIAFLVICACYIKIYLAVQNPELVAKnKDTKIAKRMAILIFTDFTCMAPISFFAISAAFKVPL 239

                       250       260       270
                ....*....|....*....|....*....|..
gi 62912474 664 VTPEAVKSVLLVVLPLPACLNPLLYLLFNPHF 695
Cdd:cd15359 240 ITVTNSKILLVLFYPINSCANPFLYAIFTKAF 271
7tmA_Relaxin_R cd15137
relaxin family peptide receptors, member of the class A family of seven-transmembrane G ...
 425-695 1.83e-19

relaxin family peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes relaxin/insulin-like family peptide receptor 1 (RXFP1 or LGR7) and 2 (RXFP2 or LGR8), which contain a very large extracellular N-terminal domain with numerous leucine-rich repeats responsible for hormone recognition and binding. Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural but low sequence similarity, and exert their physiological functions by activating a group of four GPCRs, RXFP1-4. Relaxin and INSL3 are the endogenous ligands for RXFP1 and RXFP2, respectively. Upon receptor binding, relaxin activates a variety of signaling pathways to produce second messengers such as cAMP.


Pssm-ID: 320265 [Multi-domain]  Cd Length: 284  Bit Score: 89.57  E-value: 1.83e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912474 425 IRLAVWAIVLLSVLCNGLVL---LTVFAGGPVPLppvkFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGL 501
Cdd:cd15137   3 LRVFIWVVGIIALLGNLFVLiwrLKYKEENKVHS----FLIKNLAIADFLMGVYLLIIASVDLYYRGVYIKHDEEWRSSW 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912474 502 GCRATGFLAVLGSEASVLLLTLAAVQ---CSVS-VSCVRAygKSPSLGSVRAGVLGCLALAGLAAALPLASVGE-YGASP 576
Cdd:cd15137  79 LCTFAGFLATLSSEVSVLILTLITLDrfiCIVFpFSGRRL--GLRRAIIVLACIWLIGLLLAVLPLLPWDYFGNfYGRSG 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912474 577 LCLPYAPPEGQPAALGFTVALVM-MNSFCFLVVAGAYIKLYCDLPR-----GDFEAVWDCAMVRHVAWLIFADGLLYCPV 650
Cdd:cd15137 157 VCLPLHITDERPAGWEYSVFVFLgLNFLAFVFILLSYIAMFISIRRtrkaaASRKSKRDMAVAKRFFLIVLTDFLCWIPI 236

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 62912474 651 AFLSFASMLGlFPVTPEAVKSVLLVVLPLPACLNPLLYLLFNPHF 695
Cdd:cd15137 237 IVIGILALSG-VPIPGEVYAWVAVFVLPINSALNPILYTLSTPKF 280
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 29-302 1.76e-17

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 87.60  E-value: 1.76e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912474   29 DLSMNNLTELQPGLFHHLRFLEELRLSGNHLS-HIPGqAFSGLYSLKILMLQNNQL-GGIPAEaLWELPSLQSLDLNYNK 106
Cdd:PLN00113 290 DLSDNSLSGEIPELVIQLQNLEILHLFSNNFTgKIPV-ALTSLPRLQVLQLWSNKFsGEIPKN-LGKHNNLTVLDLSTNN 367

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912474  107 LQ-------------------------EFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSA 161
Cdd:PLN00113 368 LTgeipeglcssgnlfklilfsnslegEIPKSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQGRINSR 447

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912474  162 FQYLPKLHTLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIR-LLPSGMcQQLPRLRVLELSHNQIE-ELPS-LHRCQKLE 238
Cdd:PLN00113 448 KWDMPSLQMLSLARNKFFGGLPDSFGSKRLENLDLSRNQFSgAVPRKL-GSLSELMQLKLSENKLSgEIPDeLSSCKKLV 526

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 62912474  239 EIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQL-TTLPLAG 302
Cdd:PLN00113 527 SLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQLSGEIPKNLGNVESLVQVNISHNHLhGSLPSTG 591
LRR_8 pfam13855
Leucine rich repeat;
49-107 5.12e-15

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 69.86  E-value: 5.12e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 62912474    49 LEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLDLNYNKL 107
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
235-295 1.99e-14

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 68.32  E-value: 1.99e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 62912474   235 QKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQL 295
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 30-296 2.72e-14

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 77.20  E-value: 2.72e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912474   30 LSMNNLTELQPGLFHHLRFLEELRLSGNHLS-HIPgQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLDLNYNKLQ 108
Cdd:PLN00113 219 LGYNNLSGEIPYEIGGLTSLNHLDLVYNNLTgPIP-SSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLS 297

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912474  109 -EFPVAIRTLGRLQELG-FHNNNIKAIPEkAFMGNPLLQTIHFYDN------PIQFVGRSAFQYLpKLHTLSLNG----- 175
Cdd:PLN00113 298 gEIPELVIQLQNLEILHlFSNNFTGKIPV-ALTSLPRLQVLQLWSNkfsgeiPKNLGKHNNLTVL-DLSTNNLTGeipeg 375

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912474  176 ---------------AMDIQEFPDLKGTTSLEILTLTRAGIR-LLPSGMCQ-----------------------QLPRLR 216
Cdd:PLN00113 376 lcssgnlfklilfsnSLEGEIPKSLGACRSLRRVRLQDNSFSgELPSEFTKlplvyfldisnnnlqgrinsrkwDMPSLQ 455

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912474  217 VLELSHNQIE-ELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQL 295
Cdd:PLN00113 456 MLSLARNKFFgGLPDSFGSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQL 535


                 .
gi 62912474  296 T 296
Cdd:PLN00113 536 S 536
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 167-314 4.40e-14

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 72.13  E-value: 4.40e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912474 167 KLHTLSLNGaMDIQEFPDLKGTTSLEILTLTRAGIRLLPSgmCQQLPRLRVLELSHNQIEELPSLHRCQKLEEIGLQHNR 246
Cdd:cd21340   3 RITHLYLND-KNITKIDNLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNR 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912474 247 IWEI-GADTFSQLS---------------------------SLQALDLSWNAIRSIHPeaFSTLHSLVKLDLTDNQLT-- 296
Cdd:cd21340  80 ISVVeGLENLTNLEelhienqrlppgekltfdprslaalsnSLRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQISdl 157

                       170       180
                ....*....|....*....|.
gi 62912474 297 ---TLPLAGLGGLMHLKLKGN 314
Cdd:cd21340 158 eelLDLLSSWPSLRELDLTGN 178
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 29-314 2.81e-12

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 70.65  E-value: 2.81e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912474   29 DLSMNNLTELQPGLFhhLRFLEELRLSGNHLS-------------------------HIPGqAFSGLYSLKILMLQNNQL 83
Cdd:PLN00113 124 NLSNNNFTGSIPRGS--IPNLETLDLSNNMLSgeipndigsfsslkvldlggnvlvgKIPN-SLTNLTSLEFLTLASNQL 200

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912474   84 -GGIPAE-----------------------ALWELPSLQSLDLNYNKLQ-EFPVAIRTLGRLQELGFHNNNIKA-IPEKA 137
Cdd:PLN00113 201 vGQIPRElgqmkslkwiylgynnlsgeipyEIGGLTSLNHLDLVYNNLTgPIPSSLGNLKNLQYLFLYQNKLSGpIPPSI 280

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912474  138 FMGNPL-----------------------LQTIHFYDNpiQFVGR--SAFQYLPKLHTLSLNGAMDIQEFP-DLKGTTSL 191
Cdd:PLN00113 281 FSLQKLisldlsdnslsgeipelviqlqnLEILHLFSN--NFTGKipVALTSLPRLQVLQLWSNKFSGEIPkNLGKHNNL 358

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912474  192 EILTLTRAGIR-LLPSGMCQQlPRLRVLELSHNQIE-ELP-SLHRCQKLEEIGLQHNRI----------------WEIGA 252
Cdd:PLN00113 359 TVLDLSTNNLTgEIPEGLCSS-GNLFKLILFSNSLEgEIPkSLGACRSLRRVRLQDNSFsgelpseftklplvyfLDISN 437

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 62912474  253 DTFS--------QLSSLQALDLSWNAIRSIHPEAFSTlHSLVKLDLTDNQLT-TLP--LAGLGGLMHLKLKGN 314
Cdd:PLN00113 438 NNLQgrinsrkwDMPSLQMLSLARNKFFGGLPDSFGS-KRLENLDLSRNQFSgAVPrkLGSLSELMQLKLSEN 509
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 117-299 7.87e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 62.50  E-value: 7.87e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912474 117 LGRLQELGFHNNNIKAIPEKAFMGNplLQTIHFYDNpiqfvgrsafqylpklhtlslngamDIQEFPDLKGTTSLEILTL 196
Cdd:cd21340   1 LKRITHLYLNDKNITKIDNLSLCKN--LKVLYLYDN-------------------------KITKIENLEFLTNLTHLYL 53

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912474 197 TRAGIRLLPsGMcQQLPRLRVLELSHNQIEELPSLHRCQKLEE-----------------------IG-------LQHNR 246
Cdd:cd21340  54 QNNQIEKIE-NL-ENLVNLKKLYLGGNRISVVEGLENLTNLEElhienqrlppgekltfdprslaaLSnslrvlnISGNN 131

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*
gi 62912474 247 IWEIgaDTFSQLSSLQALDLSWNAIRSIHP--EAFSTLHSLVKLDLTDNQLTTLP 299
Cdd:cd21340 132 IDSL--EPLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPVCKKP 184
7tmA_RXFP2_LGR8 cd15966
relaxin receptor 2 (or LGR8), member of the class A family of seven-transmembrane G ...
 468-695 1.09e-10

relaxin receptor 2 (or LGR8), member of the class A family of seven-transmembrane G protein-coupled receptors; Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural similarity, but low sequence similarity, and exert their physiological functions by activating a group of four G protein-coupled receptors, RXFP1-4. INSL3 is the endogenous ligand for RXFP2, which couples to the G(s) protein to increase intracellular cAMP levels, but also to the GoB protein to decrease cAMP formation. RXFP2 (or LGR8) is expressed in various tissues including the brain, kidney, muscle, testis, thyroid, uterus, and peripheral blood cells, among others.


Pssm-ID: 320632  Cd Length: 287  Bit Score: 63.27  E-value: 1.09e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912474 468 ANTLTGISCGLLASVDALTFGQFSEYGARWETGLGCRATGFLAVLGSEASVLLLTLAAVQCSVSV----SCVRAyGKSPS 543
Cdd:cd15966  45 ADCLMGVYLFFVGIFDVKYRGEYNKYALLWMESLQCRIIGFLAMLSTEVSVLLLTYLTLEKYLVIvfpfSNIRP-GKCQT 123

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912474 544 LgSVRAGVLGCLALAGLAAALPLASVGE-YGASPLCLP-YAPPEGQPAALGFTVALVM-MNSFCFLVVAGAYIKLYCDLP 620
Cdd:cd15966 124 L-IILISIWLVGFIIAVIPFWNEDFFGNyYGKNGVCFPlHSDQTEKIGAKGYSTGIFLgLNLLAFIIIVFSYSSMFCSIQ 202

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912474 621 RGDFEAV-------WDCAMVRHVAWLIFADGLLYCPVAFLsfaSMLGLFPV-TPEAVKS-VLLVVLPLPACLNPLLYLLF 691
Cdd:cd15966 203 KTGLQTTevrshihRDVAVANRFFFIVFSDAICWIPIFLL---KILSLFQVeIPGTITSwIVIFILPINSALNPILYTLT 279


                ....
gi 62912474 692 NPHF 695
Cdd:cd15966 280 TSFF 283
LRR_8 pfam13855
Leucine rich repeat;
29-83 6.76e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 55.61  E-value: 6.76e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 62912474    29 DLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQL 83
Cdd:pfam13855   7 DLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 29-253 1.77e-09

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 60.06  E-value: 1.77e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912474  29 DLSMNNLTELQ-PGLF---HHLRFLEELRLSGNHLSHIP------GQAFSGLYSLKILMLQNNQLGGIPA---EALWELP 95
Cdd:cd00116  29 RLEGNTLGEEAaKALAsalRPQPSLKELCLSLNETGRIPrglqslLQGLTKGCGLQELDLSDNALGPDGCgvlESLLRSS 108

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912474  96 SLQSLDLNYNKLQEFPVAI--RTLG----RLQELGFHNNNIKAIP----EKAFMGNPLLQTIHFYDNPIQFVG-RSAFQY 164
Cdd:cd00116 109 SLQELKLNNNGLGDRGLRLlaKGLKdlppALEKLVLGRNRLEGAScealAKALRANRDLKELNLANNGIGDAGiRALAEG 188

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912474 165 LP---KLHTLSLN-------GAMDIQE-FPDLKgttSLEILTL-----TRAGIRLLPSGMCQQLPRLRVLELSHNQIEEL 228
Cdd:cd00116 189 LKancNLEVLDLNnngltdeGASALAEtLASLK---SLEVLNLgdnnlTDAGAAALASALLSPNISLLTLSLSCNDITDD 265

                       250       260       270
                ....*....|....*....|....*....|.
gi 62912474 229 PSLHRCQ------KLEEIGLQHNRIWEIGAD 253
Cdd:cd00116 266 GAKDLAEvlaekeSLLELDLRGNKFGEEGAQ 296
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 29-315 7.57e-09

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 58.65  E-value: 7.57e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912474  29 DLSMNNLTELQPGLFHHLRFLEELrLSGNHLSHIpGQAFSGLYSLKILMLqnnqLGGIPAEALWELPSLQSLDLNYNKLQ 108
Cdd:COG5238 120 RRIMAKTLEDSLILYLALPRRINL-IQVLKDPLG-GNAVHLLGLAARLGL----LAAISMAKALQNNSVETVYLGCNQIG 193

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912474 109 EfpVAIRTLGrlqelgfhnnnikaipeKAFMGNPLLQTIHFYDNPIQFVGRSAF----QYLPKLHTLSLN-------GAM 177
Cdd:COG5238 194 D--EGIEELA-----------------EALTQNTTVTTLWLKRNPIGDEGAEILaealKGNKSLTTLDLSnnqigdeGVI 254

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912474 178 DIQEFpdLKGTTSLEILTL-----TRAGIRLLPSGMcQQLPRLRVLELSHNQIEE------LPSLHRCQKLEEIGLQHNR 246
Cdd:COG5238 255 ALAEA--LKNNTTVETLYLsgnqiGAEGAIALAKAL-QGNTTLTSLDLSVNRIGDegaialAEGLQGNKTLHTLNLAYNG 331

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912474 247 IWEIGADTFSQ----LSSLQALDLSWNAIRSIHPEAFSTL----HSLVKLDLTDNQLTTLPLAGLGGLMH------LKLK 312
Cdd:COG5238 332 IGAQGAIALAKalqeNTTLHSLDLSDNQIGDEGAIALAKYlegnTTLRELNLGKNNIGKQGAEALIDALQtnrlhtLILD 411


                ...
gi 62912474 313 GNL 315
Cdd:COG5238 412 GNL 414
LRR_8 pfam13855
Leucine rich repeat;
259-315 1.18e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 52.14  E-value: 1.18e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912474   259 SSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLP---LAGLGGLMHLKLKGNL 315
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSpgaFSGLPSLRYLDLSGNR 60
LRR_8 pfam13855
Leucine rich repeat;
213-271 1.39e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 51.76  E-value: 1.39e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 62912474   213 PRLRVLELSHNQIEELP--SLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAI 271
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDdgAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
8-299 1.60e-08

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 58.17  E-value: 1.60e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912474    8 RSARAGQNLSRAGSARRgaPRDLSMNNLTEL---QPGLFHHLRFLEE----LRLSGNHLSHIPgQAFSGlySLKILMLQN 80
Cdd:PRK15370 155 KEAPAKEAANREEAVQR--MRDCLKNNKTELrlkILGLTTIPACIPEqittLILDNNELKSLP-ENLQG--NIKTLYANS 229

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912474   81 NQLGGIPAEalweLP-SLQSLDLNYNKLQEFPVaiRTLGRLQELGFHNNNIKAIPEKAFMGnplLQTIHFYDNPIQ---- 155
Cdd:PRK15370 230 NQLTSIPAT----LPdTIQEMELSINRITELPE--RLPSALQSLDLFHNKISCLPENLPEE---LRYLSVYDNSIRtlpa 300

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912474  156 ---------FVGRSAFQYLPKlhTLSLNgamdiqefpdlkgttsLEILTLTRAGIRLLPSGMCqqlPRLRVLELSHNQIE 226
Cdd:PRK15370 301 hlpsgithlNVQSNSLTALPE--TLPPG----------------LKTLEAGENALTSLPASLP---PELQVLDVSKNQIT 359

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 62912474  227 ELPslhrcqkleeiglqhnriweigaDTFSqlSSLQALDLSWNAIRSIhPEAFSTlhSLVKLDLTDNQLTTLP 299
Cdd:PRK15370 360 VLP-----------------------ETLP--PTITTLDVSRNALTNL-PENLPA--ALQIMQASRNNLVRLP 404
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 88-296 2.02e-08

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 56.98  E-value: 2.02e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912474  88 AEALWELPSLQSLDLNYNKLQE------------FPVAIRTLGRLQELGFHNNNIKAIPEkAFMGNPLLQTIHFYDNPIQ 155
Cdd:cd00116  16 TELLPKLLCLQVLRLEGNTLGEeaakalasalrpQPSLKELCLSLNETGRIPRGLQSLLQ-GLTKGCGLQELDLSDNALG 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912474 156 FVGRSAFQYL---PKLHTLSLN--------GAMDIQEFPDLKgtTSLEILTLTRagiRLLPSGMCQQL-------PRLRV 217
Cdd:cd00116  95 PDGCGVLESLlrsSSLQELKLNnnglgdrgLRLLAKGLKDLP--PALEKLVLGR---NRLEGASCEALakalranRDLKE 169

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912474 218 LELSHNQIEE------LPSLHRCQKLEEIGLQHNRIWEIG----ADTFSQLSSLQALDLSWNAIRS-----IHPEAFSTL 282
Cdd:cd00116 170 LNLANNGIGDagiralAEGLKANCNLEVLDLNNNGLTDEGasalAETLASLKSLEVLNLGDNNLTDagaaaLASALLSPN 249

                       250
                ....*....|....
gi 62912474 283 HSLVKLDLTDNQLT 296
Cdd:cd00116 250 ISLLTLSLSCNDIT 263
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 114-303 3.03e-08

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 56.21  E-value: 3.03e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912474 114 IRTLGRLQELGFHNNNI-----KAIPEKAfMGNPLLQTIHFYDNPIQFVGR------SAFQYLPKLHTLSLN----GAMD 178
Cdd:cd00116  19 LPKLLCLQVLRLEGNTLgeeaaKALASAL-RPQPSLKELCLSLNETGRIPRglqsllQGLTKGCGLQELDLSdnalGPDG 97

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912474 179 IQEFPDLKGTTSLEILTLTRAGI-----RLLPSGMCQQLPRLRVLELSHNQIE---------ELPSLhrcQKLEEIGLQH 244
Cdd:cd00116  98 CGVLESLLRSSSLQELKLNNNGLgdrglRLLAKGLKDLPPALEKLVLGRNRLEgascealakALRAN---RDLKELNLAN 174

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 62912474 245 NRIWEIGADT----FSQLSSLQALDLSWNAIR----SIHPEAFSTLHSLVKLDLTDNQLTTLPLAGL 303
Cdd:cd00116 175 NGIGDAGIRAlaegLKANCNLEVLDLNNNGLTdegaSALAETLASLKSLEVLNLGDNNLTDAGAAAL 241
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 29-334 3.31e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 57.55  E-value: 3.31e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912474   29 DLSMNNLTELQPGLFHHLRFLEELRLSGNHLS-HIPGQAFSGLYSLKILMLQNNQL-GGIPAEAlweLPSLQSLDLNYNK 106
Cdd:PLN00113  75 DLSGKNISGKISSAIFRLPYIQTINLSNNQLSgPIPDDIFTTSSSLRYLNLSNNNFtGSIPRGS---IPNLETLDLSNNM 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912474  107 LQ-EFPvairtlgrlQELGFHNNnikaipekafmgnpllqtihfydnpiqfvgrsafqylpkLHTLSLNGAMDIQEFP-D 184
Cdd:PLN00113 152 LSgEIP---------NDIGSFSS---------------------------------------LKVLDLGGNVLVGKIPnS 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912474  185 LKGTTSLEILTLTRagiRLLPSGMCQQLPRLRVLE---LSHNQIE-ELP-SLHRCQKLEEIGLQHNRIWEIGADTFSQLS 259
Cdd:PLN00113 184 LTNLTSLEFLTLAS---NQLVGQIPRELGQMKSLKwiyLGYNNLSgEIPyEIGGLTSLNHLDLVYNNLTGPIPSSLGNLK 260

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912474  260 SLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTtlplaglGGLMHLKLK-GNLALSQAFSKD----------SFPK 328
Cdd:PLN00113 261 NLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLS-------GEIPELVIQlQNLEILHLFSNNftgkipvaltSLPR 333


                 ....*.
gi 62912474  329 LRILEV 334
Cdd:PLN00113 334 LQVLQL 339
LRR_8 pfam13855
Leucine rich repeat;
72-130 1.34e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.06  E-value: 1.34e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912474    72 SLKILMLQNNQLGGIPAEALWELPSLQSLDLNYNKLQEF-PVAIRTLGRLQELGFHNNNI 130
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
7tmA_RXFP1_LGR7 cd15965
relaxin receptor 1 (or LGR7), member of the class A family of seven-transmembrane G ...
 468-690 6.23e-07

relaxin receptor 1 (or LGR7), member of the class A family of seven-transmembrane G protein-coupled receptors; Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural but low sequence similarity, and exert their physiological functions by activating a group of four G protein-coupled receptors, RXFP1-4. Relaxin is the endogenous ligand for RXFP1, which has a large extracellular N-terminal domain containing 10 leucine-rich repeats and a unique low-density lipoprotein type A (LDLa) module which is necessary for receptor activation. Upon receptor binding, relaxin activates a variety of signaling pathways to produce second messengers such as cAMP and nitric oxide. RXFP1 is expressed in various tissues including uterus, ovary, placenta, cerebral cortex, heart, lung and kidney, among others.


Pssm-ID: 320631 [Multi-domain]  Cd Length: 287  Bit Score: 51.79  E-value: 6.23e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912474 468 ANTLTGISCGLLASVDALTFGQFSEYGARWETGLGCRATGFLAVLGSEASVLLLTLAAVQ---CSV-SVSCVRAyGKSPS 543
Cdd:cd15965  45 ADCLMGIYLFVIGAFDLKYRGEYNKHAQLWMDSTQCQLVGSLAILSTEVSVLLLTYLTLEkyiCIVyPFRCLTP-GKCRT 123

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912474 544 LGSVRAGVLGCLALAGLAAALPLASVGEYGASPLCLPY--APPEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPR 621
Cdd:cd15965 124 ITILILIWIIGFIIAFIPLSNKEFFRNYYGTNGVCFPLhsEQPESTGAQIYSVVIFLGLNLAAFIIIVFSYGSMFYSIHQ 203

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 62912474 622 GDFEAVW-------DCAMVRHVAWLIFADGLLYCPVAFLSFASMLGLfpVTPEAVKS-VLLVVLPLPACLNPLLYLL 690
Cdd:cd15965 204 TAIMATEisnhikkEMTLAKRFFFIVFTDALCWIPIFILKLLSLLQV--EIPGTISSwVVIFILPINSALNPILYTL 278
LRR_8 pfam13855
Leucine rich repeat;
119-175 6.79e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.13  E-value: 6.79e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 62912474   119 RLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNG 175
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSG 58
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 33-154 1.56e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 49.78  E-value: 1.56e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912474  33 NNLTELQPglFHHLRFLEELRLSGNHLSHIPGqaFSGLYSLKILMLQNNQLGgiPAEAL--------WELPSLQSLDLNY 104
Cdd:cd21340  56 NQIEKIEN--LENLVNLKKLYLGGNRISVVEG--LENLTNLEELHIENQRLP--PGEKLtfdprslaALSNSLRVLNISG 129

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 62912474 105 NKLQEfPVAIRTLGRLQELGFHNNNIKAIPE--KAFMGNPLLQTIHFYDNPI 154
Cdd:cd21340 130 NNIDS-LEPLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPV 180
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 48-314 2.51e-06

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 50.94  E-value: 2.51e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912474  48 FLEELRLSGNHLSHIPGQAFSGLySLKILMLQNNQLGGIPAEALWELPSL---QSLDLNYNKLQEFPVAIRTLG----RL 120
Cdd:COG5238 104 ALAETATAVATPPPDLRRIMAKT-LEDSLILYLALPRRINLIQVLKDPLGgnaVHLLGLAARLGLLAAISMAKAlqnnSV 182

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912474 121 QELGFHNNNI--KAIPE--KAFMGNPLLQTIHFYDNPIQFVGRSAF----QYLPKLHTLSLN-------GAMDIQEFpdL 185
Cdd:COG5238 183 ETVYLGCNQIgdEGIEElaEALTQNTTVTTLWLKRNPIGDEGAEILaealKGNKSLTTLDLSnnqigdeGVIALAEA--L 260

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912474 186 KGTTSLEILTL-----TRAGIRLLPSGMcQQLPRLRVLELSHNQIEE------LPSLHRCQKLEEIGLQHNRIWEIGADT 254
Cdd:COG5238 261 KNNTTVETLYLsgnqiGAEGAIALAKAL-QGNTTLTSLDLSVNRIGDegaialAEGLQGNKTLHTLNLAYNGIGAQGAIA 339

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912474 255 FSQlsSLQALdlswnairsihpeafSTLHSLvklDLTDNQLTTlplAGLGGLMHLkLKGN 314
Cdd:COG5238 340 LAK--ALQEN---------------TTLHSL---DLSDNQIGD---EGAIALAKY-LEGN 375
LRR_8 pfam13855
Leucine rich repeat;
95-154 8.05e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.05  E-value: 8.05e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 62912474    95 PSLQSLDLNYNKLQEF-PVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPI 154
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN03150 PLN03150
hypothetical protein; Provisional
 233-306 2.14e-05

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 47.89  E-value: 2.14e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 62912474  233 RCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGGL 306
Cdd:PLN03150 440 KLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLSGRVPAALGGR 513
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 213-245 2.55e-05

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 41.85  E-value: 2.55e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 62912474   213 PRLRVLELSHNQIEELPSLHRCQKLEEIGLQHN 245
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSGN 33
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 29-81 7.70e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 44.78  E-value: 7.70e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 62912474  29 DLSMNNLTELQPglFHHLRFLEELRLSGNHLSHIP--GQAFSGLYSLKILMLQNN 81
Cdd:cd21340 126 NISGNNIDSLEP--LAPLRNLEQLDASNNQISDLEelLDLLSSWPSLRELDLTGN 178
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
194-342 9.92e-05

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 45.84  E-value: 9.92e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912474  194 LTLTRAGIRLLPSGMCQQLPRLRVLElshNQIEELPSLHRcQKLEEIGLQHNRIWEIGadtfSQL-SSLQALDLSWNAIR 272
Cdd:PRK15370 204 LILDNNELKSLPENLQGNIKTLYANS---NQLTSIPATLP-DTIQEMELSINRITELP----ERLpSALQSLDLFHNKIS 275

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 62912474  273 SIhPEAFStlHSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGNlalSQAFSKDSFP-KLRILEV-PYAYQCCP 342
Cdd:PRK15370 276 CL-PENLP--EELRYLSVYDNSIRTLPAHLPSGITHLNVQSN---SLTALPETLPpGLKTLEAgENALTSLP 341
PLN03150 PLN03150
hypothetical protein; Provisional
 253-314 1.66e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 45.19  E-value: 1.66e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 62912474  253 DTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGGLMHLK---LKGN 314
Cdd:PLN03150 436 NDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRilnLNGN 500
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
 431-692 3.55e-04

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 43.43  E-value: 3.55e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912474 431 AIVLLSVLCNGLVLLTVFAGgPVPLPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQfseygarWETGLGCRATGFLA 510
Cdd:cd00637   7 LIFVVGLVGNLLVILVILRN-RRLRTVTNYFILNLAVADLLVGLLVIPFSLVSLLLGRW-------WFGDALCKLLGFLQ 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912474 511 VLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASVGEYGASPLCLPYAPPEGQPAA 590
Cdd:cd00637  79 SVSLLASILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLLLALPPLLGWGVYDYGGYCCCCLCWPDLTLS 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912474 591 LGFTVALVMMNSF-CFLVVAGAYIKLYCDL-------------PRGDFEAVWDCAMVRHVAWLIFADGLLYCPVAFLSFA 656
Cdd:cd00637 159 KAYTIFLFVLLFLlPLLVIIVCYVRIFRKLrrhrrrirssssnSSRRRRRRRERKVTKTLLIVVVVFLLCWLPYFILLLL 238

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 62912474 657 SMLGLFPV-TPEAVKSVLLVVLPLPACLNPLLYLLFN 692
Cdd:cd00637 239 DVFGPDPSpLPRILYFLALLLAYLNSAINPIIYAFFN 275
PLN03150 PLN03150
hypothetical protein; Provisional
 48-153 1.51e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 42.11  E-value: 1.51e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912474   48 FLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQL-GGIPAeALWELPSLQSLDLNYNKLQ-EFPVAIRTLGRLQELGF 125
Cdd:PLN03150 419 FIDGLGLDNQGLRGFIPNDISKLRHLQSINLSGNSIrGNIPP-SLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNL 497

                         90       100
                 ....*....|....*....|....*....
gi 62912474  126 HNNNIKAIPEKAFMGNPLLQTI-HFYDNP 153
Cdd:PLN03150 498 NGNSLSGRVPAALGGRLLHRASfNFTDNA 526
PLN03150 PLN03150
hypothetical protein; Provisional
 30-114 1.57e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 42.11  E-value: 1.57e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912474   30 LSMNN--LTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLDLNYNKL 107
Cdd:PLN03150 423 LGLDNqgLRGFIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSL 502


                 ....*...
gi 62912474  108 Q-EFPVAI 114
Cdd:PLN03150 503 SgRVPAAL 510
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 72-107 1.59e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.84  E-value: 1.59e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 62912474    72 SLKILMLQNNQLGGIPAeaLWELPSLQSLDLNYNKL 107
Cdd:pfam12799   2 NLEVLDLSNNQITDIPP--LAKLPNLETLDLSGNNK 35
LRR_8 pfam13855
Leucine rich repeat;
142-225 1.67e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.50  E-value: 1.67e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912474   142 PLLQTIHFYDNPIQFVGRSAFQYLPklhtlslngamdiqefpdlkgttSLEILTLTRAGIRLLPSGMCQQLPRLRVLELS 221
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLS-----------------------NLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLS 57


                  ....
gi 62912474   222 HNQI 225
Cdd:pfam13855  58 GNRL 61
LRR smart00370
Leucine-rich repeats, outliers;
258-280 3.88e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 35.41  E-value: 3.88e-03
                           10        20
                   ....*....|....*....|...
gi 62912474    258 LSSLQALDLSWNAIRSIHPEAFS 280
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQ 23
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
258-280 3.88e-03

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 35.41  E-value: 3.88e-03
                           10        20
                   ....*....|....*....|...
gi 62912474    258 LSSLQALDLSWNAIRSIHPEAFS 280
Cdd:smart00369   1 LPNLRELDLSNNQLSSLPPGAFQ 23
LRR smart00370
Leucine-rich repeats, outliers;
46-69 6.80e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 34.63  E-value: 6.80e-03
                           10        20
                   ....*....|....*....|....
gi 62912474     46 LRFLEELRLSGNHLSHIPGQAFSG 69
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
46-69 6.80e-03

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 34.63  E-value: 6.80e-03
                           10        20
                   ....*....|....*....|....
gi 62912474     46 LRFLEELRLSGNHLSHIPGQAFSG 69
Cdd:smart00369   1 LPNLRELDLSNNQLSSLPPGAFQG 24
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 96-327 7.13e-03

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 40.24  E-value: 7.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912474    96 SLQSLDLNYNKLQEFPVAIRTLGRLQELGFH-NNNIKAIPEKAFMGNplLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLN 174
Cdd:PLN03210  612 NLVKLQMQGSKLEKLWDGVHSLTGLRNIDLRgSKNLKEIPDLSMATN--LETLKLSDCSSLVELPSSIQYLNKLEDLDMS 689

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912474   175 GAMDIQEFPDLKGTTSLEILTLTR-AGIRLLPSGMCQqlprLRVLELSHNQIEELPSLHRCQKLEEIGL---QHNRIWE- 249
Cdd:PLN03210  690 RCENLEILPTGINLKSLYRLNLSGcSRLKSFPDISTN----ISWLDLDETAIEEFPSNLRLENLDELILcemKSEKLWEr 765

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62912474   250 --IGADTFSQLS-SLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTD-NQLTTLPLAglgglMHLKLKGNLALSQAFSKDS 325
Cdd:PLN03210  766 vqPLTPLMTMLSpSLTRLFLSDIPSLVELPSSIQNLHKLEHLEIENcINLETLPTG-----INLESLESLDLSGCSRLRT 840


                  ..
gi 62912474   326 FP 327
Cdd:PLN03210  841 FP 842
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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