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Conserved domains on  [gi|61557411|ref|NP_001013262|]
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tetraspanin-13 [Rattus norvegicus]

Protein Classification

tetraspanin family protein( domain architecture ID 11992908)

tetraspanin family protein is a transmembrane (TM) glycoprotein with four TM segments that facilitates the interaction of membrane and intracellular signaling molecules (such as integrins, pro-growth factors and their receptors, protein kinase-C) in the formation of membrane signaling microdomains (also referred to as the tetraspanin web)

Gene Ontology:  GO:0016020
PubMed:  15763890|11756464|19709882|16024509|32974937
SCOP:  4001512

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Tetraspanin pfam00335
Tetraspanin family;
55-190 4.74e-07

Tetraspanin family;


:

Pssm-ID: 459767  Cd Length: 183  Bit Score: 48.08  E-value: 4.74e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557411    55 FLFLIALVGLIGAVKHHQVLLFFYMIILLLVFIVQFSVSCACLALNREQQGQL-------LEVGWNNTASARND------ 121
Cdd:pfam00335  54 VIFLVGFLGCCGALKENRCLLLTYFVLLLLLFLAELAAGILAFVYRDKLSGLLsnwlkksLEDGYRDWLDLYSClnsald 133

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557411   122 -IQRNLNCCGfrnynpndtcpascaksnqkcsSCAPIIGEYAGEVLRFVGGIGLFFSFTEILGVWLTYRY 190
Cdd:pfam00335 134 sLQSEFGCCG----------------------GCKEKLLEWLRKNLKIIGAGVIALGVIQLLGIILACCL 181
 
Name Accession Description Interval E-value
Tetraspanin pfam00335
Tetraspanin family;
55-190 4.74e-07

Tetraspanin family;


Pssm-ID: 459767  Cd Length: 183  Bit Score: 48.08  E-value: 4.74e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557411    55 FLFLIALVGLIGAVKHHQVLLFFYMIILLLVFIVQFSVSCACLALNREQQGQL-------LEVGWNNTASARND------ 121
Cdd:pfam00335  54 VIFLVGFLGCCGALKENRCLLLTYFVLLLLLFLAELAAGILAFVYRDKLSGLLsnwlkksLEDGYRDWLDLYSClnsald 133

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557411   122 -IQRNLNCCGfrnynpndtcpascaksnqkcsSCAPIIGEYAGEVLRFVGGIGLFFSFTEILGVWLTYRY 190
Cdd:pfam00335 134 sLQSEFGCCG----------------------GCKEKLLEWLRKNLKIIGAGVIALGVIQLLGIILACCL 181
TM4SF2_6_like_LEL cd03161
Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF2_6_like subfamily. ...
 115-153 8.13e-04

Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF2_6_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This subfamily contaions transmembrane 4 superfamily 2 (TM4SF2) or Tspan-7, transmembrane 4 superfamily 6 (TM4SF6) or Tspan-6, and related proteins. TM4SF2 has been identified as involved in some forms of X-linked mental retardation.


Pssm-ID: 239414  Cd Length: 104  Bit Score: 37.34  E-value: 8.13e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*..
gi 61557411 115 TASARNDIQRNLNCCGFRNYN--------PNDTCPASCAKSNQKCSS 153
Cdd:cd03161  28 RSDAVDTVQRTLHCCGVENYTdwlnspyfLEKGIPLSCCKNRSDCSP 74
 
Name Accession Description Interval E-value
Tetraspanin pfam00335
Tetraspanin family;
55-190 4.74e-07

Tetraspanin family;


Pssm-ID: 459767  Cd Length: 183  Bit Score: 48.08  E-value: 4.74e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557411    55 FLFLIALVGLIGAVKHHQVLLFFYMIILLLVFIVQFSVSCACLALNREQQGQL-------LEVGWNNTASARND------ 121
Cdd:pfam00335  54 VIFLVGFLGCCGALKENRCLLLTYFVLLLLLFLAELAAGILAFVYRDKLSGLLsnwlkksLEDGYRDWLDLYSClnsald 133

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557411   122 -IQRNLNCCGfrnynpndtcpascaksnqkcsSCAPIIGEYAGEVLRFVGGIGLFFSFTEILGVWLTYRY 190
Cdd:pfam00335 134 sLQSEFGCCG----------------------GCKEKLLEWLRKNLKIIGAGVIALGVIQLLGIILACCL 181
TM4SF2_6_like_LEL cd03161
Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF2_6_like subfamily. ...
 115-153 8.13e-04

Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF2_6_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This subfamily contaions transmembrane 4 superfamily 2 (TM4SF2) or Tspan-7, transmembrane 4 superfamily 6 (TM4SF6) or Tspan-6, and related proteins. TM4SF2 has been identified as involved in some forms of X-linked mental retardation.


Pssm-ID: 239414  Cd Length: 104  Bit Score: 37.34  E-value: 8.13e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*..
gi 61557411 115 TASARNDIQRNLNCCGFRNYN--------PNDTCPASCAKSNQKCSS 153
Cdd:cd03161  28 RSDAVDTVQRTLHCCGVENYTdwlnspyfLEKGIPLSCCKNRSDCSP 74
TM4SF8_like_LEL cd03163
Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF8_like subfamily. ...
 111-154 3.47e-03

Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF8_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This subfamily contaions transmembrane 4 superfamily 8 (TM4SF8) or Tspan-3 and related proteins. Tspan-3 has been reported to form a complex with integrin beta1 and OSP/claudin-11, which may be involved in oligodendrocyte proliferation and migration.


Pssm-ID: 239416  Cd Length: 105  Bit Score: 35.86  E-value: 3.47e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 61557411 111 GWNNTASARNDIQRNLNCCGFRNY-----------NPNDTCPASCAKSNqkCSSC 154
Cdd:cd03163  25 GTNAESRAVDYLQRQLQCCGIHNYtdwentpwfkeSKNNSVPLSCCKET--FTSC 77
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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