|
Name |
Accession |
Description |
Interval |
E-value |
| PLN02437 |
PLN02437 |
ribonucleoside--diphosphate reductase large subunit |
1-792 |
0e+00 |
|
ribonucleoside--diphosphate reductase large subunit
Pssm-ID: 178056 [Multi-domain] Cd Length: 813 Bit Score: 1547.78 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 1 MHVIKRDGRQERVMFDKITSRIQKLCYGLNMDFVDPAQITMKVIQGLYSGVTTVELDTLAAETAATLTTKHPDYAILAAR 80
Cdd:PLN02437 1 MYVVKRDGRQETVHFDKITARLKKLSYGLSQDHCDPVLVAQKVCAGVYKGVTTSQLDELAAETAAAMTTNHPDYAILAAR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 81 IAVSNLHKETKKVFSDVMEDLYNYINPHNGRHSPMVASSTLEIVMAHKDRLNSAIIYDRDFSYNYFGFKTLERSYLLKIN 160
Cdd:PLN02437 81 IAVSNLHKNTKKSFSETVKDMYNHVNERSGLKAPLIADDVYDIIMKNAARLDSEIIYDRDFDYDYFGFKTLERSYLLKVN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 161 GKVAERPQHMLMRVSVGIHKEDIDAAIETYNLLSEKWFTHASPTLFNAGTNRPQLSSCFLLSMKDDSIEGIYDTLKQCAL 240
Cdd:PLN02437 161 GKVVERPQHMLMRVSVGIHKDDIESAIKTYHLMSQRWFTHASPTLFNAGTPRPQLSSCFLICMKDDSIEGIYDTLKECAV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 241 ISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGNKRPGAFAIYLEPWHLDIFEFLDLKKNTGK 320
Cdd:PLN02437 241 ISKSAGGIGLSVHNIRATGSYIRGTNGTSNGIVPMLRVFNDTARYVDQGGGKRKGAFAIYLEPWHADIFEFLDLRKNHGK 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 321 EEQRARDLFFALWIPDLFMKRVETNQDWSLMCPNECPGLDEVWGEEFEKLYESYEKQGRVRKVVKAQQLWYAIIESQTET 400
Cdd:PLN02437 321 EEHRARDLFYALWIPDLFMERVQSNGDWSLFCPNEAPGLADCWGEEFERLYTKYEREGKAKKVVQAQQLWFAILESQIET 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 401 GTPYMLYKDSCNRKSNQQNLGTIKCSNLCTEIVEYTSKDEVAVCNLASLALNMYV-------------------TPEHTY 461
Cdd:PLN02437 401 GTPYMLFKDSCNRKSNQQNLGTIKSSNLCTEIIEYTSPTETAVCNLASIALPRFVrekgvpleshpsklvgslgSKNRYF 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 462 DFEKLAEVTKVIVRNLNKIIDINYYPIPEAHLSNKRHRPIGIGVQGLADAFILMRYPFESPEAQLLNKQIFETIYYGALE 541
Cdd:PLN02437 481 DFEKLAEVTAVVTRNLNKIIDVNYYPVETARRSNMRHRPIGIGVQGLADAFILLGMPFDSPEAQQLNKDIFETIYYHALK 560
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 542 ASCDLAKEYGPYETYEGSPVSKGILQYDMWNVTPTDLWDWKLLKEKIAKYGIRNSLLIAPMPTASTAQILGNNESIEPYT 621
Cdd:PLN02437 561 ASSELAAREGPYETYAGSPVSKGILQPDMWGVTPSGRWDWAALREMISKNGVRNSLLVAPMPTASTSQILGNNECFEPYT 640
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 622 SNIYTRRVLSGEFQIVNPHLLKDLTERGLWNEEMKNQIIACNGSIQSIPEIPEDLKQLYKTVWEISQKTVLKMAAERGAF 701
Cdd:PLN02437 641 SNIYSRRVLSGEFVVVNKHLLHDLTEMGLWTPTLKNKIIAENGSVQKIPEIPDDLKAIYKTVWEIKQRTLVDMAADRGCY 720
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 702 IDQSQSLNIHIAEPNYGKLTSMHFYGWKQGLKTGMYYLRTRPAANPIQFTLNKEKLKDKEKALKEEEEKERNT--AAMVC 779
Cdd:PLN02437 721 IDQSQSLNIHMDQPNFGKLTSLHFYAWSKGLKTGMYYLRSRAAADAIKFTVDTASLKPSATGVAAPEEEDVETkmAQMVC 800
|
810
....*....|...
gi 61557388 780 SLENREECLMCGS 792
Cdd:PLN02437 801 SLDNREECLACGS 813
|
|
| NrdA |
COG0209 |
Ribonucleotide reductase alpha subunit [Nucleotide transport and metabolism]; Ribonucleotide ... |
85-754 |
0e+00 |
|
Ribonucleotide reductase alpha subunit [Nucleotide transport and metabolism]; Ribonucleotide reductase alpha subunit is part of the Pathway/BioSystem: Pyrimidine salvage
Pssm-ID: 439979 [Multi-domain] Cd Length: 665 Bit Score: 866.04 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 85 NLHKETKKVFsdvmEDLYNYINPH-NGRHSPmvasstlEIVMAHKDRLNSAIIYDRDFSYNYFGFKTLERSYLLK-INGK 162
Cdd:COG0209 1 QLRKEALGQY----KSFSEKIKYVeEGLYDE-------RLLEEDLEELAAAIDPERDRFFSYNALKTLYDRYLLKdEDGK 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 163 VAERPQHMLMRVSVGIH-----KEDIDAAIETYNLLSEKWFTHASPTLFNAGTNRPQLSSCFLLSMkDDSIEGIYDTLKQ 237
Cdd:COG0209 70 PLETPQDLFMRVAMGLAaaekpEDREEWAKEFYDLLSSLRFLPATPTLFNAGTPRGQLSSCFVLPV-EDSLESIFDALKD 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 238 CALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGnKRPGAFAIYLEPWHLDIFEFLDLKKN 317
Cdd:COG0209 149 AALLSKSGGGVGFNFSRLRPKGSPIKGTGGVSSGPVPFMKVFDDAAVAVNQGG-KRRGANMVYLRVWHPDIEEFLDLKKN 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 318 TGKEEQRARDLFFALWIPDLFMKRVETNQDWSLMCPNECPGLDEVWGEEFEKLYESYEKQGRVRKVVKAQQLWYAIIESQ 397
Cdd:COG0209 228 NGDERRRLHNFNISVWIPDLFMEAVEEDEDWTLFSPREVPDLYGLYGEEFEEAYEEYEADGRVYKTIKARELWRKILESA 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 398 TETGTPYMLYKDSCNRKSNQQNLGTIKCSNLCTEIVEYTSKDEVAVCNLASLALNMYVTpEHTYDFEKLAEVTKVIVRNL 477
Cdd:COG0209 308 WETGEPGILFKDTINRRNPLPHLGVIHSSNLCGEIPLLPYESEDASCNLGSINLAKFVK-DGEFDWEKLEETVRTAVRFL 386
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 478 NKIIDINYYPIPEAHLSNKRHRPIGIGVQGLADAFILMRYPFESPEAQLLNKQIFETIYYGALEASCDLAKEYGPYETYE 557
Cdd:COG0209 387 DNVIDINDYPVPEIEKANRRHRPIGLGVMGLADALAKLGIPYDSEEARELADEIMEFINYYAYKASAELAKERGAFPAFE 466
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 558 GSPVSKGILQYDMW--NVTPTDLWDWKLLKEKIAKYGIRNSLLIAPMPTASTAQILGNNESIEPYTSNIYTRRVLS-GEF 634
Cdd:COG0209 467 GSKYAKGILPFDKYldDLLIPTTLDWDALREDIKKHGLRNSTLTAIAPTGTISLIAGTTSGIEPIFSLVYVRKVLDgGEF 546
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 635 QIVNPHLLKDLTERGLWNEEMKNQIIAcNGSIQSIPEIPEDLKQLYKTVWEISQKTVLKMAAERGAFIDQSQSLNIHIA- 713
Cdd:COG0209 547 TVVNPYLVRALKELGLWDEELVEKIKE-DGSVQDIDELPEELKELYVTAYEIDPEWHIDMQAARQKHVDQAISKTLNLPn 625
|
650 660 670 680
....*....|....*....|....*....|....*....|.
gi 61557388 714 EPNYGKLTSMHFYGWKQGLKTgMYYLRTRPAANPIQFTLNK 754
Cdd:COG0209 626 DATVEDLAELYLLAWKLGLKG-IYYYRDGSRTGQVLSTGKK 665
|
|
| RNR_I |
cd01679 |
Class I ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive ... |
167-741 |
0e+00 |
|
Class I ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive synthesis of deoxyribonucleotides from their corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. RNRs are separated into three classes based on their metallocofactor usage. Class I RNRs, found in eukaryotes, bacteria, and many viruses, use a diiron-tyrosyl radical. Class II RNRs, found in bacteria, bacteriophage, algae and archaea, use coenzyme B12 (adenosylcobalamin, AdoCbl). Class III RNRs, found in anaerobic bacteria, bacteriophages, and archaea, use an FeS cluster and S-adenosylmethionine to generate a glycyl radical. Many organisms have more than one class of RNR present in their genomes. All three RNRs have a ten-stranded alpha-beta barrel domain that is structurally similar to the domain of PFL (pyruvate formate lyase). Class I RNR is oxygen-dependent and can be subdivided into classes Ia (eukaryotes, prokaryotes, viruses and phages) and Ib (which is found in prokaryotes only). It is a tetrameric enzyme of two alpha and two beta subunits; this model covers the major part of the alpha or large subunit, called R1 in class Ia and R1E in class Ib.
Pssm-ID: 153088 [Multi-domain] Cd Length: 460 Bit Score: 773.25 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 167 PQHMLMRVSVGIHKEDIDAAIETYNLLSEKWFTHASPTLFNAGTNRPQLSSCFLLSMkDDSIEGIYDTLKQCALISKSAG 246
Cdd:cd01679 1 PQDRLMRVALGLASGDLEWAKEFYDLLSKQRFTPATPTLFNAGTPRGQLSSCFLLTV-DDSLESIYDTIKECAQLSKIGG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 247 GIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGnKRPGAFAIYLEPWHLDIFEFLDLKKNTGKEEQRAR 326
Cdd:cd01679 80 GIGLNLSNIRATGSPIRGTNGASNGVIPFLKLLNDTARYVDQGG-QRKGAGAVYLEIWHPDIEEFLDLKKNNGDERRRAR 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 327 DLFFALWIPDLFMKRVEtnqdwslmcpnecpgldevwgeefeklyesyekqgrvrkvvkaQQLWYAIIESQTETGTPYML 406
Cdd:cd01679 159 DLFYGVWIPDLFMERVE-------------------------------------------RDLWRKILESQFETGYPYIL 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 407 YKDSCNRKSNQQNLGTIKCSNLCTEIVEYTSK-----DEVAVCNLASLALNMYVTpehtydFEKLAEVTKVIVRNLNKII 481
Cdd:cd01679 196 FKDTCNRKNPQKHLGTIKSSNLCTEILQPTSPsedepGEDAVCNLASINLGNFVT------FEKLEEVVKLAVRALDNVI 269
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 482 DINYYPIPEAHLSNKRHRPIGIGVQGLADAFILMRYPFESPEAQLLNKQIFETIYYGALEASCDLAKEYGpyetyegspv 561
Cdd:cd01679 270 DLNYYPVPEAKRSNMRHRAIGLGVMGLHDYLALLRIPYESEEALDLNDRIFETINYYALKASCELAKERG---------- 339
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 562 skgilqydmwnvtptdlwdwkllkekiakyGIRNSLLIAPMPTASTAQILGNNESIEPYTSNIYTRRVLSGEFQIVNPHL 641
Cdd:cd01679 340 ------------------------------GLRNSLLLAIAPTASISQILGATPSIEPITSNIYVRRVLSGEFPVVNPHL 389
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 642 LKDLTERGlwneemknqiiacngsiqsipeipedlkqLYKTVWEISQKTVLKMAAERGAFIDQSQSLNIHIAEP-NYGKL 720
Cdd:cd01679 390 EKDLWEYG-----------------------------LYKTAYEIDQRWLIDLAADRQKHIDQGQSLNLFLTPPaTTRDL 440
|
570 580
....*....|....*....|.
gi 61557388 721 TSMHFYGWKQGLKTGmYYLRT 741
Cdd:cd01679 441 NSLYFYAWKKGLKTL-YYLRT 460
|
|
| Ribonuc_red_lgC |
pfam02867 |
Ribonucleotide reductase, barrel domain; |
216-738 |
0e+00 |
|
Ribonucleotide reductase, barrel domain;
Pssm-ID: 460729 [Multi-domain] Cd Length: 487 Bit Score: 755.97 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 216 SSCFLLSMkDDSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGnKRPG 295
Cdd:pfam02867 1 SSCFLLSV-EDSLDSIYDTLKEAALLSKGGGGIGLNLSKLRAKGSPIRGTGGASSGVVPFLKLFDDSARYVNQGG-KRRG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 296 AFAIYLEPWHLDIFEFLDLKKNTGKEEQRARDLFFALWIPDLFMKRVETNQDWSLMCPNECPGLDEVWGEEFEKL-YESY 374
Cdd:pfam02867 79 AAAVYLEVWHPDIEEFLDLKKNNGDEEVRARNLNLGVWVPDLFMERVEADEDWTLFSPREAPDLEDLYGEEFEKEyYERE 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 375 EKQGRVRKVVKAQQLWYAIIESQTETGTPYMLYKDSCNRKSNQQNLGTIKCSNLCTEIVEYTSKDEVAVCNLASLALNMY 454
Cdd:pfam02867 159 ENEGIRKKTVKARELWFKIAKSQIETGYPYILFKDAVNRKNPQKHLGTIKSSNLCTEIVQPTSPSEIAVCNLASINLAKF 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 455 VTPEHTYDFEKLAEVTKVIVRNLNKIIDINYYPIPEAHLSNKRHRPIGIGVQGLADAFILMRYPFESPEAQLLNKQIFET 534
Cdd:pfam02867 239 VEFGGTFDFEKLREVVKLAVRALDNVIDINDYPVPEARRSNKRHRPIGLGVMGLADALAKLGIPYDSEEARDLNDKIFET 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 535 IYYGALEASCDLAKEYGPYETYEGSPVSKGILQYDMWNVTPTD------LWDWKLLKEKIAKYGIRNSLLIAPMPTASTA 608
Cdd:pfam02867 319 MYYYALKASSELAKEKGPFPGFEGSKYSKGILQFDKYVKTDFApkasktREDWEELREDIKKYGLRNSQLTAIAPTGSIS 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 609 QILGNNESIEPYTSNIYTRRVLSgefqivnphllkdlterglwneemknqiiacngsiqsipeipEDLKQLYKTVWEISQ 688
Cdd:pfam02867 399 QIAGATESIEPIFSNVYSRKVLS------------------------------------------EETKEYYKTAYDIDQ 436
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|.
gi 61557388 689 KTVLKMAAERGAFIDQSQSLNIHI-AEPNYGKLTSMHFYGWKQGLKTGMYY 738
Cdd:pfam02867 437 KAHIDMAAARQPFVDQSISKTLFLpNDATTSDLKSLYLYAWKLGLKTIYYY 487
|
|
| NrdE_NrdA |
TIGR02506 |
ribonucleoside-diphosphate reductase, alpha subunit; This model represents the alpha (large) ... |
145-742 |
0e+00 |
|
ribonucleoside-diphosphate reductase, alpha subunit; This model represents the alpha (large) chain of the class I ribonucleotide reductase (RNR). RNR's are responsible for the conversion of the ribose sugar of RNA into the deoxyribose sugar of DNA. This is the rate-limiting step of DNA biosynthesis. Class I RNR's generate the required radical (on tyrosine) via a "non-heme" iron cofactor which resides in the beta (small) subunit. The alpha subunit contains the catalytic and allosteric regulatory sites. The mechanism of this enzyme requires molecular oxygen. E. Coli contains two versions of this enzyme which are regulated independently (NrdAB and NrdEF, where NrdA and NrdE are the large chains). Most organisms contain only one, but the application of the gene symbols NrdA and NrdE are somewhat arbitrary. This model identifies RNR's in diverse clades of bacteria, eukaryotes as well as numerous DNA viruses and phage. [Purines, pyrimidines, nucleosides, and nucleotides, 2'-Deoxyribonucleotide metabolism]
Pssm-ID: 274170 [Multi-domain] Cd Length: 617 Bit Score: 745.74 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 145 YFGFKTLERSYLLKIN--GKVAERPQHMLMRVSVGIH-----KEDIDAAIETYNLLSEKWFTHASPTLFNAGTNRPQLSS 217
Cdd:TIGR02506 1 YMGLKELYNRYLLRNAatGAIYESPQEAYMRVAMGLAslepkDTRLADAIRFYDLLSRLKISPATPTLFNAGTPRGQLSS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 218 CFLLSMKDDSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGnKRPGAF 297
Cdd:TIGR02506 81 CFLLDVTDDTLESIYKAIDDVAQLSKHGGGIGLNLTKLRAIGSPIRGTNNASKGIIPFLKLLDSSVEAVNQGG-KRPGAA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 298 AIYLEPWHLDIFEFLDLKKNTGKEEQRARDLFFALWIPDLFMKRVETNQDWSLMCPNECPGLDEVWGEEFEKLYESYEKQ 377
Cdd:TIGR02506 160 AVYLEVWHPDIEEFLDLKKNNGDERRRCDNLFYGLWIPDLFMKRVEEDKDWYLFSPYDVPGLYGLYGEEFEEEYERLEKD 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 378 GRVRK---VVKAQQLWYAIIESQTETGTPYMLYKDSCNRK-SNQQNLGTIKCSNLCTEIVEYTSKD---EVAVCNLASLA 450
Cdd:TIGR02506 240 VEARKkirKVSARDLMKDILRTRVETGRPYILFKDAVNKHnPFKTGGGAIKMSNLCTEITQPTDDShkgETAVCNLASVN 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 451 LNMYVTpEHTYDFEKLAEVTKVIVRNLNKIIDINYYPIPEAHLSNKRHRPIGIGVQGLADAFILMRYPFESPEAQLLNKQ 530
Cdd:TIGR02506 320 LANFVM-EDKFDFSELEDAVRIAVRFLDNVIDLQNYPTAPAAKSNQRRRSIGIGVMGLHDVLAKLGLPYDSEEARDLNDR 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 531 IFETIYYGALEASCDLAKEYGPYETYEGSPVSKGILQYDMWNVTPTDLW-------DWKLLKEKIAKYGIRNSLLIAPMP 603
Cdd:TIGR02506 399 IFEAIYYYAIKASAELAKEKGPFPGFSGSKYAKGWLHPDTWEKTIDPKTsmapteeDWEALRERIKEYGLRNSQLTALMP 478
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 604 TASTAQILGNNESIEPYTSNIYTRRVLSGEFQIVNPHLLKDLTERGLWNEEMKNQIIACNGSIQSIPEIPEDLKQLYKTV 683
Cdd:TIGR02506 479 TASSSQLTGVTESIEPVFSNIFTKKTLSGEFLIPNKYLMKELEELGLWDADRRGDIVENVGSPQPIAAIPETLKYKYKTA 558
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 684 WEISQKTVLKMAAERGAFIDQSQSLNIHIAE-PNYGKLTSMHFYGWKQGLKTgMYYLRTR 742
Cdd:TIGR02506 559 YELDQEALIDMAADRQKFVDQSISLNLFLTEeVTAKDLLKLLLLAWKKGLKT-MYYCRSR 617
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PLN02437 |
PLN02437 |
ribonucleoside--diphosphate reductase large subunit |
1-792 |
0e+00 |
|
ribonucleoside--diphosphate reductase large subunit
Pssm-ID: 178056 [Multi-domain] Cd Length: 813 Bit Score: 1547.78 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 1 MHVIKRDGRQERVMFDKITSRIQKLCYGLNMDFVDPAQITMKVIQGLYSGVTTVELDTLAAETAATLTTKHPDYAILAAR 80
Cdd:PLN02437 1 MYVVKRDGRQETVHFDKITARLKKLSYGLSQDHCDPVLVAQKVCAGVYKGVTTSQLDELAAETAAAMTTNHPDYAILAAR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 81 IAVSNLHKETKKVFSDVMEDLYNYINPHNGRHSPMVASSTLEIVMAHKDRLNSAIIYDRDFSYNYFGFKTLERSYLLKIN 160
Cdd:PLN02437 81 IAVSNLHKNTKKSFSETVKDMYNHVNERSGLKAPLIADDVYDIIMKNAARLDSEIIYDRDFDYDYFGFKTLERSYLLKVN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 161 GKVAERPQHMLMRVSVGIHKEDIDAAIETYNLLSEKWFTHASPTLFNAGTNRPQLSSCFLLSMKDDSIEGIYDTLKQCAL 240
Cdd:PLN02437 161 GKVVERPQHMLMRVSVGIHKDDIESAIKTYHLMSQRWFTHASPTLFNAGTPRPQLSSCFLICMKDDSIEGIYDTLKECAV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 241 ISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGNKRPGAFAIYLEPWHLDIFEFLDLKKNTGK 320
Cdd:PLN02437 241 ISKSAGGIGLSVHNIRATGSYIRGTNGTSNGIVPMLRVFNDTARYVDQGGGKRKGAFAIYLEPWHADIFEFLDLRKNHGK 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 321 EEQRARDLFFALWIPDLFMKRVETNQDWSLMCPNECPGLDEVWGEEFEKLYESYEKQGRVRKVVKAQQLWYAIIESQTET 400
Cdd:PLN02437 321 EEHRARDLFYALWIPDLFMERVQSNGDWSLFCPNEAPGLADCWGEEFERLYTKYEREGKAKKVVQAQQLWFAILESQIET 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 401 GTPYMLYKDSCNRKSNQQNLGTIKCSNLCTEIVEYTSKDEVAVCNLASLALNMYV-------------------TPEHTY 461
Cdd:PLN02437 401 GTPYMLFKDSCNRKSNQQNLGTIKSSNLCTEIIEYTSPTETAVCNLASIALPRFVrekgvpleshpsklvgslgSKNRYF 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 462 DFEKLAEVTKVIVRNLNKIIDINYYPIPEAHLSNKRHRPIGIGVQGLADAFILMRYPFESPEAQLLNKQIFETIYYGALE 541
Cdd:PLN02437 481 DFEKLAEVTAVVTRNLNKIIDVNYYPVETARRSNMRHRPIGIGVQGLADAFILLGMPFDSPEAQQLNKDIFETIYYHALK 560
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 542 ASCDLAKEYGPYETYEGSPVSKGILQYDMWNVTPTDLWDWKLLKEKIAKYGIRNSLLIAPMPTASTAQILGNNESIEPYT 621
Cdd:PLN02437 561 ASSELAAREGPYETYAGSPVSKGILQPDMWGVTPSGRWDWAALREMISKNGVRNSLLVAPMPTASTSQILGNNECFEPYT 640
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 622 SNIYTRRVLSGEFQIVNPHLLKDLTERGLWNEEMKNQIIACNGSIQSIPEIPEDLKQLYKTVWEISQKTVLKMAAERGAF 701
Cdd:PLN02437 641 SNIYSRRVLSGEFVVVNKHLLHDLTEMGLWTPTLKNKIIAENGSVQKIPEIPDDLKAIYKTVWEIKQRTLVDMAADRGCY 720
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 702 IDQSQSLNIHIAEPNYGKLTSMHFYGWKQGLKTGMYYLRTRPAANPIQFTLNKEKLKDKEKALKEEEEKERNT--AAMVC 779
Cdd:PLN02437 721 IDQSQSLNIHMDQPNFGKLTSLHFYAWSKGLKTGMYYLRSRAAADAIKFTVDTASLKPSATGVAAPEEEDVETkmAQMVC 800
|
810
....*....|...
gi 61557388 780 SLENREECLMCGS 792
Cdd:PLN02437 801 SLDNREECLACGS 813
|
|
| NrdA |
COG0209 |
Ribonucleotide reductase alpha subunit [Nucleotide transport and metabolism]; Ribonucleotide ... |
85-754 |
0e+00 |
|
Ribonucleotide reductase alpha subunit [Nucleotide transport and metabolism]; Ribonucleotide reductase alpha subunit is part of the Pathway/BioSystem: Pyrimidine salvage
Pssm-ID: 439979 [Multi-domain] Cd Length: 665 Bit Score: 866.04 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 85 NLHKETKKVFsdvmEDLYNYINPH-NGRHSPmvasstlEIVMAHKDRLNSAIIYDRDFSYNYFGFKTLERSYLLK-INGK 162
Cdd:COG0209 1 QLRKEALGQY----KSFSEKIKYVeEGLYDE-------RLLEEDLEELAAAIDPERDRFFSYNALKTLYDRYLLKdEDGK 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 163 VAERPQHMLMRVSVGIH-----KEDIDAAIETYNLLSEKWFTHASPTLFNAGTNRPQLSSCFLLSMkDDSIEGIYDTLKQ 237
Cdd:COG0209 70 PLETPQDLFMRVAMGLAaaekpEDREEWAKEFYDLLSSLRFLPATPTLFNAGTPRGQLSSCFVLPV-EDSLESIFDALKD 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 238 CALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGnKRPGAFAIYLEPWHLDIFEFLDLKKN 317
Cdd:COG0209 149 AALLSKSGGGVGFNFSRLRPKGSPIKGTGGVSSGPVPFMKVFDDAAVAVNQGG-KRRGANMVYLRVWHPDIEEFLDLKKN 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 318 TGKEEQRARDLFFALWIPDLFMKRVETNQDWSLMCPNECPGLDEVWGEEFEKLYESYEKQGRVRKVVKAQQLWYAIIESQ 397
Cdd:COG0209 228 NGDERRRLHNFNISVWIPDLFMEAVEEDEDWTLFSPREVPDLYGLYGEEFEEAYEEYEADGRVYKTIKARELWRKILESA 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 398 TETGTPYMLYKDSCNRKSNQQNLGTIKCSNLCTEIVEYTSKDEVAVCNLASLALNMYVTpEHTYDFEKLAEVTKVIVRNL 477
Cdd:COG0209 308 WETGEPGILFKDTINRRNPLPHLGVIHSSNLCGEIPLLPYESEDASCNLGSINLAKFVK-DGEFDWEKLEETVRTAVRFL 386
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 478 NKIIDINYYPIPEAHLSNKRHRPIGIGVQGLADAFILMRYPFESPEAQLLNKQIFETIYYGALEASCDLAKEYGPYETYE 557
Cdd:COG0209 387 DNVIDINDYPVPEIEKANRRHRPIGLGVMGLADALAKLGIPYDSEEARELADEIMEFINYYAYKASAELAKERGAFPAFE 466
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 558 GSPVSKGILQYDMW--NVTPTDLWDWKLLKEKIAKYGIRNSLLIAPMPTASTAQILGNNESIEPYTSNIYTRRVLS-GEF 634
Cdd:COG0209 467 GSKYAKGILPFDKYldDLLIPTTLDWDALREDIKKHGLRNSTLTAIAPTGTISLIAGTTSGIEPIFSLVYVRKVLDgGEF 546
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 635 QIVNPHLLKDLTERGLWNEEMKNQIIAcNGSIQSIPEIPEDLKQLYKTVWEISQKTVLKMAAERGAFIDQSQSLNIHIA- 713
Cdd:COG0209 547 TVVNPYLVRALKELGLWDEELVEKIKE-DGSVQDIDELPEELKELYVTAYEIDPEWHIDMQAARQKHVDQAISKTLNLPn 625
|
650 660 670 680
....*....|....*....|....*....|....*....|.
gi 61557388 714 EPNYGKLTSMHFYGWKQGLKTgMYYLRTRPAANPIQFTLNK 754
Cdd:COG0209 626 DATVEDLAELYLLAWKLGLKG-IYYYRDGSRTGQVLSTGKK 665
|
|
| RNR_I |
cd01679 |
Class I ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive ... |
167-741 |
0e+00 |
|
Class I ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive synthesis of deoxyribonucleotides from their corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. RNRs are separated into three classes based on their metallocofactor usage. Class I RNRs, found in eukaryotes, bacteria, and many viruses, use a diiron-tyrosyl radical. Class II RNRs, found in bacteria, bacteriophage, algae and archaea, use coenzyme B12 (adenosylcobalamin, AdoCbl). Class III RNRs, found in anaerobic bacteria, bacteriophages, and archaea, use an FeS cluster and S-adenosylmethionine to generate a glycyl radical. Many organisms have more than one class of RNR present in their genomes. All three RNRs have a ten-stranded alpha-beta barrel domain that is structurally similar to the domain of PFL (pyruvate formate lyase). Class I RNR is oxygen-dependent and can be subdivided into classes Ia (eukaryotes, prokaryotes, viruses and phages) and Ib (which is found in prokaryotes only). It is a tetrameric enzyme of two alpha and two beta subunits; this model covers the major part of the alpha or large subunit, called R1 in class Ia and R1E in class Ib.
Pssm-ID: 153088 [Multi-domain] Cd Length: 460 Bit Score: 773.25 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 167 PQHMLMRVSVGIHKEDIDAAIETYNLLSEKWFTHASPTLFNAGTNRPQLSSCFLLSMkDDSIEGIYDTLKQCALISKSAG 246
Cdd:cd01679 1 PQDRLMRVALGLASGDLEWAKEFYDLLSKQRFTPATPTLFNAGTPRGQLSSCFLLTV-DDSLESIYDTIKECAQLSKIGG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 247 GIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGnKRPGAFAIYLEPWHLDIFEFLDLKKNTGKEEQRAR 326
Cdd:cd01679 80 GIGLNLSNIRATGSPIRGTNGASNGVIPFLKLLNDTARYVDQGG-QRKGAGAVYLEIWHPDIEEFLDLKKNNGDERRRAR 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 327 DLFFALWIPDLFMKRVEtnqdwslmcpnecpgldevwgeefeklyesyekqgrvrkvvkaQQLWYAIIESQTETGTPYML 406
Cdd:cd01679 159 DLFYGVWIPDLFMERVE-------------------------------------------RDLWRKILESQFETGYPYIL 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 407 YKDSCNRKSNQQNLGTIKCSNLCTEIVEYTSK-----DEVAVCNLASLALNMYVTpehtydFEKLAEVTKVIVRNLNKII 481
Cdd:cd01679 196 FKDTCNRKNPQKHLGTIKSSNLCTEILQPTSPsedepGEDAVCNLASINLGNFVT------FEKLEEVVKLAVRALDNVI 269
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 482 DINYYPIPEAHLSNKRHRPIGIGVQGLADAFILMRYPFESPEAQLLNKQIFETIYYGALEASCDLAKEYGpyetyegspv 561
Cdd:cd01679 270 DLNYYPVPEAKRSNMRHRAIGLGVMGLHDYLALLRIPYESEEALDLNDRIFETINYYALKASCELAKERG---------- 339
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 562 skgilqydmwnvtptdlwdwkllkekiakyGIRNSLLIAPMPTASTAQILGNNESIEPYTSNIYTRRVLSGEFQIVNPHL 641
Cdd:cd01679 340 ------------------------------GLRNSLLLAIAPTASISQILGATPSIEPITSNIYVRRVLSGEFPVVNPHL 389
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 642 LKDLTERGlwneemknqiiacngsiqsipeipedlkqLYKTVWEISQKTVLKMAAERGAFIDQSQSLNIHIAEP-NYGKL 720
Cdd:cd01679 390 EKDLWEYG-----------------------------LYKTAYEIDQRWLIDLAADRQKHIDQGQSLNLFLTPPaTTRDL 440
|
570 580
....*....|....*....|.
gi 61557388 721 TSMHFYGWKQGLKTGmYYLRT 741
Cdd:cd01679 441 NSLYFYAWKKGLKTL-YYLRT 460
|
|
| Ribonuc_red_lgC |
pfam02867 |
Ribonucleotide reductase, barrel domain; |
216-738 |
0e+00 |
|
Ribonucleotide reductase, barrel domain;
Pssm-ID: 460729 [Multi-domain] Cd Length: 487 Bit Score: 755.97 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 216 SSCFLLSMkDDSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGnKRPG 295
Cdd:pfam02867 1 SSCFLLSV-EDSLDSIYDTLKEAALLSKGGGGIGLNLSKLRAKGSPIRGTGGASSGVVPFLKLFDDSARYVNQGG-KRRG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 296 AFAIYLEPWHLDIFEFLDLKKNTGKEEQRARDLFFALWIPDLFMKRVETNQDWSLMCPNECPGLDEVWGEEFEKL-YESY 374
Cdd:pfam02867 79 AAAVYLEVWHPDIEEFLDLKKNNGDEEVRARNLNLGVWVPDLFMERVEADEDWTLFSPREAPDLEDLYGEEFEKEyYERE 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 375 EKQGRVRKVVKAQQLWYAIIESQTETGTPYMLYKDSCNRKSNQQNLGTIKCSNLCTEIVEYTSKDEVAVCNLASLALNMY 454
Cdd:pfam02867 159 ENEGIRKKTVKARELWFKIAKSQIETGYPYILFKDAVNRKNPQKHLGTIKSSNLCTEIVQPTSPSEIAVCNLASINLAKF 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 455 VTPEHTYDFEKLAEVTKVIVRNLNKIIDINYYPIPEAHLSNKRHRPIGIGVQGLADAFILMRYPFESPEAQLLNKQIFET 534
Cdd:pfam02867 239 VEFGGTFDFEKLREVVKLAVRALDNVIDINDYPVPEARRSNKRHRPIGLGVMGLADALAKLGIPYDSEEARDLNDKIFET 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 535 IYYGALEASCDLAKEYGPYETYEGSPVSKGILQYDMWNVTPTD------LWDWKLLKEKIAKYGIRNSLLIAPMPTASTA 608
Cdd:pfam02867 319 MYYYALKASSELAKEKGPFPGFEGSKYSKGILQFDKYVKTDFApkasktREDWEELREDIKKYGLRNSQLTAIAPTGSIS 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 609 QILGNNESIEPYTSNIYTRRVLSgefqivnphllkdlterglwneemknqiiacngsiqsipeipEDLKQLYKTVWEISQ 688
Cdd:pfam02867 399 QIAGATESIEPIFSNVYSRKVLS------------------------------------------EETKEYYKTAYDIDQ 436
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|.
gi 61557388 689 KTVLKMAAERGAFIDQSQSLNIHI-AEPNYGKLTSMHFYGWKQGLKTGMYY 738
Cdd:pfam02867 437 KAHIDMAAARQPFVDQSISKTLFLpNDATTSDLKSLYLYAWKLGLKTIYYY 487
|
|
| NrdE_NrdA |
TIGR02506 |
ribonucleoside-diphosphate reductase, alpha subunit; This model represents the alpha (large) ... |
145-742 |
0e+00 |
|
ribonucleoside-diphosphate reductase, alpha subunit; This model represents the alpha (large) chain of the class I ribonucleotide reductase (RNR). RNR's are responsible for the conversion of the ribose sugar of RNA into the deoxyribose sugar of DNA. This is the rate-limiting step of DNA biosynthesis. Class I RNR's generate the required radical (on tyrosine) via a "non-heme" iron cofactor which resides in the beta (small) subunit. The alpha subunit contains the catalytic and allosteric regulatory sites. The mechanism of this enzyme requires molecular oxygen. E. Coli contains two versions of this enzyme which are regulated independently (NrdAB and NrdEF, where NrdA and NrdE are the large chains). Most organisms contain only one, but the application of the gene symbols NrdA and NrdE are somewhat arbitrary. This model identifies RNR's in diverse clades of bacteria, eukaryotes as well as numerous DNA viruses and phage. [Purines, pyrimidines, nucleosides, and nucleotides, 2'-Deoxyribonucleotide metabolism]
Pssm-ID: 274170 [Multi-domain] Cd Length: 617 Bit Score: 745.74 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 145 YFGFKTLERSYLLKIN--GKVAERPQHMLMRVSVGIH-----KEDIDAAIETYNLLSEKWFTHASPTLFNAGTNRPQLSS 217
Cdd:TIGR02506 1 YMGLKELYNRYLLRNAatGAIYESPQEAYMRVAMGLAslepkDTRLADAIRFYDLLSRLKISPATPTLFNAGTPRGQLSS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 218 CFLLSMKDDSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGnKRPGAF 297
Cdd:TIGR02506 81 CFLLDVTDDTLESIYKAIDDVAQLSKHGGGIGLNLTKLRAIGSPIRGTNNASKGIIPFLKLLDSSVEAVNQGG-KRPGAA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 298 AIYLEPWHLDIFEFLDLKKNTGKEEQRARDLFFALWIPDLFMKRVETNQDWSLMCPNECPGLDEVWGEEFEKLYESYEKQ 377
Cdd:TIGR02506 160 AVYLEVWHPDIEEFLDLKKNNGDERRRCDNLFYGLWIPDLFMKRVEEDKDWYLFSPYDVPGLYGLYGEEFEEEYERLEKD 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 378 GRVRK---VVKAQQLWYAIIESQTETGTPYMLYKDSCNRK-SNQQNLGTIKCSNLCTEIVEYTSKD---EVAVCNLASLA 450
Cdd:TIGR02506 240 VEARKkirKVSARDLMKDILRTRVETGRPYILFKDAVNKHnPFKTGGGAIKMSNLCTEITQPTDDShkgETAVCNLASVN 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 451 LNMYVTpEHTYDFEKLAEVTKVIVRNLNKIIDINYYPIPEAHLSNKRHRPIGIGVQGLADAFILMRYPFESPEAQLLNKQ 530
Cdd:TIGR02506 320 LANFVM-EDKFDFSELEDAVRIAVRFLDNVIDLQNYPTAPAAKSNQRRRSIGIGVMGLHDVLAKLGLPYDSEEARDLNDR 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 531 IFETIYYGALEASCDLAKEYGPYETYEGSPVSKGILQYDMWNVTPTDLW-------DWKLLKEKIAKYGIRNSLLIAPMP 603
Cdd:TIGR02506 399 IFEAIYYYAIKASAELAKEKGPFPGFSGSKYAKGWLHPDTWEKTIDPKTsmapteeDWEALRERIKEYGLRNSQLTALMP 478
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 604 TASTAQILGNNESIEPYTSNIYTRRVLSGEFQIVNPHLLKDLTERGLWNEEMKNQIIACNGSIQSIPEIPEDLKQLYKTV 683
Cdd:TIGR02506 479 TASSSQLTGVTESIEPVFSNIFTKKTLSGEFLIPNKYLMKELEELGLWDADRRGDIVENVGSPQPIAAIPETLKYKYKTA 558
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 684 WEISQKTVLKMAAERGAFIDQSQSLNIHIAE-PNYGKLTSMHFYGWKQGLKTgMYYLRTR 742
Cdd:TIGR02506 559 YELDQEALIDMAADRQKFVDQSISLNLFLTEeVTAKDLLKLLLLAWKKGLKT-MYYCRSR 617
|
|
| PRK07207 |
PRK07207 |
ribonucleoside-diphosphate reductase subunit alpha; |
1-790 |
0e+00 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 235966 [Multi-domain] Cd Length: 965 Bit Score: 670.90 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 1 MHVIKRDGrqERVMFDkiTSRIQKL----CYGLnmDFVDPAQITMKVIQGLYSGVTTVELDTLAAETAATLTTKHPDYAI 76
Cdd:PRK07207 149 LNVTLDDG--VRRPLD--MARLRALieeaCEGL--EAVDAEPILAETLKNLYDGVPMDEVYKALILAARTLIEKEPNYSY 222
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 77 LAARIAVSNLHKE-------TKKVFSDVMEDLY-----NYINP--HNGRHSPMVASSTLeivmahkDRLNSAIIYDRDFS 142
Cdd:PRK07207 223 VTARLLLDTLRREalgflgvPEEVTQAEMATRYaeyfpAFIKKgiEAELLDPKLAQFDL-------ERLGAALDPERDLQ 295
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 143 YNYFGFKTLERSYLLKINGKVAERPQHMLMRVSVGIHKEDIDA---AIETYNLLSEKWFTHASPTLFNAGTNRPQLSSCF 219
Cdd:PRK07207 296 FTYLGLQTLYDRYFLHVDGTRIELPQAFFMRVAMGLALNEIDRearAIEFYNLLSSFDFMSSTPTLFNSGTLRPQLSSCY 375
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 220 LLSMKDDsIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGnKRPGAFAI 299
Cdd:PRK07207 376 LTTVPDD-LDGIYEAIKDNALLSKFAGGLGNDWTPVRALGSHIKGTNGKSQGVVPFLKVVNDTAVAVNQGG-KRKGAVCA 453
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 300 YLEPWHLDIFEFLDLKKNTGKEEQRARDLFFALWIPDLFMKRVETNQDWSLMCPNECPGLDEVWGEEFEKLYESYEKQG- 378
Cdd:PRK07207 454 YLETWHLDIEEFLELRKNTGDDRRRTHDMNTANWIPDLFMKRVMEDGEWTLFSPSEVPDLHDLFGKAFEEAYTAYEAKAa 533
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 379 ----RVRKVVKAQQLWYAIIESQTETGTPYMLYKDSCNRKSNQQNLGTIKCSNLCTEIVEYTSKDEVAVCNLASLALNMY 454
Cdd:PRK07207 534 rgeiKLFKKIPAVDLWRKMLSMLFETGHPWITFKDPCNLRSPQQHVGVVHSSNLCTEITLNTSDDEIAVCNLGSVNLVAH 613
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 455 VTPEHTYDFEKLAEVTKVIVRNLNKIIDINYYPIPEAHLSNKRHRPIGIGVQGLADAFILMRYPFESPEAQLLNKQIFET 534
Cdd:PRK07207 614 IKDGAKLDHEKLKRTVSTAMRMLDNVIDINYYAVPKARNSNLRHRPVGLGIMGFQDALYLLRIPYASDEAVEFADRSMEA 693
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 535 IYYGALEASCDLAKEYGPYETYEGSPVSKGILQYD-----------MWNVTPTDLWDWKLLKEKIAKYGIRNSLLIAPMP 603
Cdd:PRK07207 694 VSYYAIWASTELAEERGRYSSYEGSLWSRGILPIDslkllaearggYLEVDRSSTLDWDALRARIKKHGMRNSNCMAIAP 773
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 604 TASTAQILGNNESIEPYTSNIYTRRVLSGEFQIVNPHLLKDLTERGLWNEEMKNQIIACNGSIQSIPEIPEDLKQLYKTV 683
Cdd:PRK07207 774 TATISNIIGVSQSIEPTYQNLYVKSNLSGEFTVVNPYLVRDLKARGLWDEVMVNDLKYFDGSLQRIDRIPADLKALYATA 853
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 684 WEISQKTVLKMAAERGAFIDQSQSLNIHIAEPNYGKLTSMHFYGWKQGLKTgMYYLRTRPAANPIQFTLNKEKL------ 757
Cdd:PRK07207 854 FEVDPRWLVEAASRRQKWIDQAQSLNLYMAGASGKKLDETYKLAWLRGLKT-TYYLRTLGATHVEKSTVNTGALnavssg 932
|
810 820 830
....*....|....*....|....*....|...
gi 61557388 758 KDKEKALKEEEEKERNTAAMVCSLENrEECLMC 790
Cdd:PRK07207 933 GGGAGGAAAAAAAPPAADPKACSIDD-PDCEAC 964
|
|
| PRK12365 |
PRK12365 |
ribonucleoside-diphosphate reductase subunit alpha; |
3-790 |
0e+00 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 171440 [Multi-domain] Cd Length: 1046 Bit Score: 563.80 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 3 VIKRDGRQERVMFDKITSRIQKLCYGLNmDFVDPAQITMKVIQGLYSGVTTVELDTLAAETAATLTTKHPDYAILAARIA 82
Cdd:PRK12365 238 VLSKDGSTYTMTKSQLLAHFAWACSRFP-ETTDAALLADMAFANFYSGIKESEVVLACIMAARANIEKEPDYAFVAAELL 316
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 83 VSNLHKET--KKVFSDVMEDLY-----NYI-NPHNGRHSPMVASSTLeivmahkDRLNSAIIYDRDFSYNYFGFKTLERS 154
Cdd:PRK12365 317 LDVVYKEAlgKSKYDEDLEEAHkdhfkRYIlEGDTYRLNPELKHYDL-------DALAEALDLSRDLQFSYMGVQNLYDR 389
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 155 YLLKINGKVAERPQHMLMRVSVGIH-KEDIDA---AIETYNLLSEKWFTHASPTLFNAGTNRPQLSSCFLLSMKDDsIEG 230
Cdd:PRK12365 390 YFNHHEGRRLETPQIFWMRVSMGLAlNEGQDKtswAITFYNLLSTFRYTPATPTLFNSGMRHSQLSSCYLSTVQDD-LVH 468
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 231 IYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGnKRPGAFAIYLEPWHLDIFE 310
Cdd:PRK12365 469 IYKVISDNAMLSKWAGGIGNDWTAVRATGALIKGTNGKSQGVIPFIKVANDTAVAVNQGG-KRKGAVCVYLEVWHLDYED 547
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 311 FLDLKKNTGKEEQRARDLFFALWIPDLFMKRVETNQDWSLMCPNECPGLDEVWGEEFEKLYESYEKQ---GRVR--KVVK 385
Cdd:PRK12365 548 FLELRKNTGDERRRTHDINTASWIPDLFFKRLQQKGTWTLFSPDDVPGLHEAYGEEFEKLYEEYERKvdtGEIRlyKKVE 627
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 386 AQQLWYAIIESQTETGTPYMLYKDSCNRKSNQQNLGTIKCSNLCTEIVEYTSKDEVAVCNLASLALNMYVTPEHTyDFEK 465
Cdd:PRK12365 628 AEDLWRKMLSMLYETGHPWMTFKDPSNIRSAQDHKGVVRCSNLCTEILLNCSETETAVCNLGSINLVEHIVNDGL-DEEK 706
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 466 LAEVTKVIVRNLNKIIDINYYPIPEAHLSNKRHRPIGIGVQGLADAFILMRYPFESPEAQLLNKQIFETIYYGALEASCD 545
Cdd:PRK12365 707 LSETISIAIRILDNVIDINFYPTKEAKEANLAHRAIGLGVMGFQDALYKLNISYASQEAVEFADYSSELIAYYAILASSL 786
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 546 LAKEYGPYETYEGSPVSKGILQYDMWN------------VTPTDLWDWKLLKEKIAKYGIRNSLLIAPMPTASTAQILGN 613
Cdd:PRK12365 787 LAKERGTYSSYKGSKWDRGYLPIDTIEllkeyrgeanllMDTSSRKDWEPVRSLIKEYGMRNSQLMAIAPTATISNIIGV 866
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 614 NESIEPYTSNIYTRRVLSGEFQIVNPHLLKDLTERGLWNEEMKNQIIACNGSIQSIPEIPEDLKQLYKTVWEISQKTVLK 693
Cdd:PRK12365 867 TQSIEPTYKHLFVKSNLSGEFTIPNVYLIEKLKKLGIWDADMLDDLKYFDGSLLEIERIPDHLKKIFLTAFEIEPEWIIE 946
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 694 MAAERGAFIDQSQSLNIHIAEPNYGKLTSMHFYGWKQGLKTgMYYLRTRpAANPIQ--FT-LNKEKLK---DKEKALKEE 767
Cdd:PRK12365 947 CASRRQKWIDMGQSLNLYLAEPDGKKLSNMYLTAWKKGLKT-TYYLRSS-AATSVEksFVdINKRGIQprwMKNKSASTS 1024
|
810 820
....*....|....*....|...
gi 61557388 768 EEKERNTAAMVCSLEnrEECLMC 790
Cdd:PRK12365 1025 IVVERAKKTPVCSLE--EGCESC 1045
|
|
| PRK06539 |
PRK06539 |
ribonucleoside-diphosphate reductase subunit alpha; |
3-756 |
7.37e-166 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 180610 [Multi-domain] Cd Length: 822 Bit Score: 500.60 E-value: 7.37e-166
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 3 VIKRDGRQERVMFDKITSRIQKLCYGLNMDFVDPAQITMKVIQGLYSGVTTVELDTLAAETAATLTTKHPDYAILAARIA 82
Cdd:PRK06539 5 VVKRDGSKEPYDANKVNAAIEDAARGLDDAITWVTQLASELEITLFDGITTQQLDEAVIQVALQNVKDDPAFDTVAARLL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 83 VSNLHKETKKVFSDVMEDLYNYINPHNGRHSPMVASSTLEIVMAHK---DRLNSAIIYDRDFSYNYFGFKTLERSYLLKI 159
Cdd:PRK06539 85 LKKIYKRVLGDYDSPEELQDLHANHFRRTIEKGVAEGLLDSRLGGLfdlERLAAALDPTRDELLKYIGVVTLNNRYGIRA 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 160 -NGKVAERPQHMLMRVSVGI---HKEDIDAAIETYNLLSEKWFTHASPTLFNAGTNRPQLSSCFLLSMKDDsIEGIYDTL 235
Cdd:PRK06539 165 rNGDALEVPQYFWMRIAMGLslnEDDPTSSALAFYEKMSKLEYLAAGSTLVNAGTPYPQLSNCFVMEMQDD-IEHIAKTT 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 236 KQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGnKRPGAFAIYLEPWHLDIFEFLDLK 315
Cdd:PRK06539 244 RDVMWLTKGTGGIGLSVSKLRAQGSPIRSNNTTSTGPIPFMHTIDSVLRAVSRGG-KKFGALCFYMENWHMDFPEFLDLR 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 316 KNTGKEEQRARDLFFALWIPDLFMKRVETNQDWSLMCPNECPGLDEVWGEEFEKLYESYEKQ---GRVR--KVVKAQQLW 390
Cdd:PRK06539 323 QNSGDPYRRTRTANTAVWISDEFMKRVQNDEDWYLFDPLETPDLNELYGKAFSKRYAQYVEQaeaGRIRmfKRITAREQF 402
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 391 YAIIESQTETGTPYMLYKDSCNRKSNQQNLGTIKCSNLCTEIVEYTSKDEVAVCNLASLALNMY-VTPEhtYDFEKLAEV 469
Cdd:PRK06539 403 RAILMSLQTTSHPWLTWKDTINNRALNNNTGTIHLSNLCTEICLPQDRDNVSVCNLASINLSRHlADGE--LDWAQLEES 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 470 TKVIVRNLNKIIDINYYPIPEAHLSNKRHRPIGIGVQGLADAFILMRYPFESPEAQLLNKQIFETIYYGALEASCDLAKE 549
Cdd:PRK06539 481 TRLAVRQLDNLIDITASSVKEADFSNQQNRAIGLGVMGFTDMVERLGYSYESEEAYDLIDRIMEHISYAAIDESADLAAE 560
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 550 YGPYETYEGSPVSKGILQYDMW-----------NVTPTDLWDWKLLKEKIaKYGIRNSLLIAPMPTASTAQILGNNESIE 618
Cdd:PRK06539 561 RGAYPNFEGSRWSRGMVPVDSIalleadrgvpvDVNRTTRLDWDALRAKV-RGGMRNATLMAIAPTASIGLVAGTTPGLD 639
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 619 PYTSNIYTRRVLSGEFQIVNPHLLKDLTERGLWnEEMKNQIIACNGSIQSIPEIPEDLKQLYKTVWEISQKTVLKMAAER 698
Cdd:PRK06539 640 PQFSQIFSRSTSSGKFLEVNRNLVADLKELGLW-ETVREEILRSQGDIQEIAAIPDEIKALYRTSFQLSPYAFLEVAARA 718
|
730 740 750 760 770
....*....|....*....|....*....|....*....|....*....|....*...
gi 61557388 699 GAFIDQSQSLNIHIAEPNYGKLTSMHFYGWKQGLKTgMYYLRTRPAANPIQFTLNKEK 756
Cdd:PRK06539 719 QKWVDQAISRNMYLESRDIGDMMDIYTAAWEMGVKT-TYYLHMKPRHTAEQSTVKVNK 775
|
|
| PRK08447 |
PRK08447 |
ribonucleoside-diphosphate reductase subunit alpha; |
1-741 |
4.02e-148 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 236266 [Multi-domain] Cd Length: 789 Bit Score: 453.41 E-value: 4.02e-148
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 1 MHVIKRDGRQERVMFDKITSRIQKLCYGLN------------MDFVDpaQITMKVIQG--LYSGVTTVELDTlaaetaat 66
Cdd:PRK08447 2 ITVVKRNGRIEPLDISKIQKYTSDAVEGLEgvsqselevdakIQFRD--GITTEEIQQtlIKTAVDKIDIDR-------- 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 67 lttkhPDYAILAARIAVSNL-HKETKKVFSDVMEDlYNYINPHNGRhspmvasstleIVMAHKDR-----LNSAIIYDRD 140
Cdd:PRK08447 72 -----PNWTFVAARLFLYDLyHKVSGFTGYNHLKE-YFEKGEKEGR-----------ILLGLKEKydlddLNAYIKPERD 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 141 FSYNYFGFKTLERSYLLK-INGKVAERPQHMLMRVSVGIHKEDIDA---AIETYNLLSEKWFTHASPTLFNAGTNRPQLS 216
Cdd:PRK08447 135 LQFNYLGIKTLYDRYLIKdRNNNPIELPQHMFMAIAMFLAQNELDPqkwAKKFYDVISKFEVMLATPTLSNARTTRHQLS 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 217 SCFLLSMKDDsIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGNkRPGA 296
Cdd:PRK08447 215 SCYIGSTPDN-IEGIFDSYKEMALLSKYGGGIGWDWSKVRAMGSYIDGHKNAAGGIIPFLKITNDIAIAVDQLGT-RKGA 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 297 FAIYLEPWHLDIFEFLDLKKNTGKEEQRARDLFFALWIPDLFMKRVETNQDWSLMCPNECPGLDEVWGEEFEKLYESYEK 376
Cdd:PRK08447 293 IAVYLEPWHMDISDFIDLRKNSGEERRRAHDLFPALWINDLFMKRVEEDAMWTLFDPYECKDLTELYGEEFEKRYLEYEK 372
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 377 QGRVRK-VVKAQQLWYAIIESQTETGTPYMLYKDSCNRKSNQQNLGTIKCSNLCTEI------------VEYTSKDEV-- 441
Cdd:PRK08447 373 DEKIIKeYINAKELWKKILTNYFETGLPFLCFKDNANRANPNAHAGIIRSSNLCTEIfqntapnhykikIEFEDGSIEff 452
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 442 ------------------------------------------AVCNLASLALNMYVTPehtydfEKLAEVTKVIVRNLNK 479
Cdd:PRK08447 453 eeeelvtvdsgitkkakkitsldslkgkkiyivekekkdgktAVCNLASINLSKINTK------EDIERVVPIAIRMLDN 526
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 480 IIDINYYPIPEAHLSNKRHRPIGIGVQGLADAFILMRYPFESPEAQLLNKQIFETIYYGALEASCDLAKEYGPYETYEGS 559
Cdd:PRK08447 527 VIDLNFYPNRKVKATNLKSRAIGLGVMGEAQMLAEHKIAWGSKEHLEKIDEIMEQISYNAIDASSNLALEKGVYPDFEGS 606
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 560 PVSKGILQYDMWN------VTPTDLW----DWKLLKEKIAKYGIRNSLLIAPMPTASTAQILGNNESIEPytsnIYTRRv 629
Cdd:PRK08447 607 NWSKGIFPIDKANeeakklVERGGLFdsacDWEGLREKVKKDGMRNGYLMAIAPTSSISILVGTTQTIEP----VYKRK- 681
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 630 lsgefqivnphllkdlterglWNEEMKNQIIACngsiqSIPEIPEDLKQLYKTVWEISQKTVLKMAAERGAFIDQSQSLN 709
Cdd:PRK08447 682 ---------------------WFEENLSGLIPV-----VVPNLSPETWQYYTPAYDLDQKDLIKAAAVRQKWIDQGQSLN 735
|
810 820 830
....*....|....*....|....*....|....
gi 61557388 710 IHIA-EPNYGK-LTSMHFYGWKQGLKTgMYYLRT 741
Cdd:PRK08447 736 IFLSlDKASGKyLNEIYTLAWKLGLKS-TYYLRS 768
|
|
| PRK09209 |
PRK09209 |
ribonucleoside-diphosphate reductase subunit alpha; |
72-742 |
3.01e-131 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 181700 [Multi-domain] Cd Length: 761 Bit Score: 408.73 E-value: 3.01e-131
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 72 PDYAILAARIAVSNLHKETKKV-FSDVME---DLYNYINP--HNGRHSPMVAS--STLEIvmahkDRLNSAIIYDRDFSY 143
Cdd:PRK09209 82 PEWTFFAARLYLNRLYKRASRNrFYDASEkygSFVGLQESlaERGIYSNDLLKrySKEEL-----IEAGKMIDPERDKLF 156
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 144 NYFGFKTLERSYLLK-INGKVAERPQHMLMRVSVGI-HKEDIDAAI----ETYNLLSEKWFTHASPTLFNAGTNRPQLSS 217
Cdd:PRK09209 157 TYIGLYLLADRYLATdSDRNVYELPQERWLTIALYLmQNEPRERRMqlvkEAYWALSNLYMTVATPTLANAGKVGGQLSS 236
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 218 CFLLSMkDDSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGnKRPGAF 297
Cdd:PRK09209 237 CFIDTV-DDSLQGIYDSNTDVARVSKHGGGVGAYLGKVRSRGSDIRGFKGVSSGVIPWIKQLNNTAVSVDQLG-QRKGAI 314
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 298 AIYLEPWHLDIFEFLDLKKNTGKEEQRARDLFFALWIPDLFMKRVETNQDWSLMCPNECP-----GLDEVWGEE-----F 367
Cdd:PRK09209 315 AVYLDVWHKDIESFLDLRLNNGDERLRAHDVFTGVCIPDLFMEAVERRGDWYLFDPHEVKkvmgwYLEDFYDEKkgdgsF 394
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 368 EKLYESYEKQGRV-RKVVKAQQLWYAIIESQTETGTPYMLYKDSCNRKSNQQNLGTIKCSNLCTEIV----------EYT 436
Cdd:PRK09209 395 REKYEECVADERLsRKTVKAIDIMKRIMVSQLETGNPFMFYRDEVNRMNPNKHEGMIYSSNLCTEIMqnmsptvmiqEII 474
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 437 SKDEV---------AVCNLASLALNMYVTPEhtydfeKLAEVTKVIVRNLNKIIDINYYPIPEAHLSNKRHRPIGIGVQG 507
Cdd:PRK09209 475 SGGQIvitkqpgdfVVCNLSSINLGRAVTAD------VLERLIPIQVRMLDNVIDLNQLPVPQATITNQKYRAIGLGTFG 548
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 508 LADAFILMRYPFESPEAQLLNKQIFETIYYGALEASCDLAKEYGPYETYEGSPVSKGilQY-DMWNVTPTDlwdWKLLKE 586
Cdd:PRK09209 549 WHHLLALKGIAWESEEAVQYADELYERINYLTIQASMELAKEKGAYPVFKGSDWQTG--EYfERRGYNSPQ---WDELAA 623
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 587 KIAKYGIRNSLLIAPMPTASTAQILGNNESIEPytsnIYTRrvlsgefqivnphllkdltergLWNEEMKNQIIACngsi 666
Cdd:PRK09209 624 QVAENGVRNAYLMAVAPNMSTAQIAGSTASIDP----IYSA----------------------FYYEEKKDYRRPV---- 673
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 667 qSIPEIPEDLKQLY-KTVWEISQKTVLKMAAERGAFIDQSQSLNIHIaePN---YGKLTSMHFYGWKQGLKTgMYYLRTR 742
Cdd:PRK09209 674 -TAPDLSLDTWPYYeKGAYKVDQFWSIRQNAARQRHVDQSISFNFYV--PStirASELLDLHMTAWKEGLKT-TYYVRST 749
|
|
| PRK09102 |
PRK09102 |
ribonucleoside-diphosphate reductase subunit alpha; |
125-745 |
3.75e-127 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 236378 [Multi-domain] Cd Length: 601 Bit Score: 392.78 E-value: 3.75e-127
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 125 MAHKDRLNSAII-YDRDFSYNYFGFKTLERSYLLKingkvAERPQHMLMRVSVgiHKEDIDAAIET--YNLLSEKWFTHA 201
Cdd:PRK09102 2 KMQNKLVFQINIdRSRDAWLTEFGKATLRDRYLLE-----GESYQDLFARIAE--AYADIDPEHAQrfYDYMSRGWFMPA 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 202 SPTLFNAGTNRPQLSSCFLLSMkDDSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIaGTNGNSNGLVPMLRVYNN 281
Cdd:PRK09102 75 TPVLSNGGTDRGLPISCFLNYV-EDSLEGIVNTWNENVWLAKRGGGIGSYWGNVRSIGEPI-RNNGKSSGIIPFIKVMDS 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 282 TARYVDQGGNKRpGAFAIYLEPWHLDIFEFLDLKKNTGKEEQRARDLFFALWIPDLFMKRVETNQDWSLMCPnecpglde 361
Cdd:PRK09102 153 LTLAISQGSLRR-GSFAVYLDIEHPEIEEFLDIRKPTGDPNRKALNLHHGVCVTDEFMEAVEDGDEWDLISP-------- 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 362 vwgeefeklyesyeKQGRVRKVVKAQQLWYAIIESQTETGTPYMLYKDSCNRK--SNQQNLG-TIKCSNLCTEI-----V 433
Cdd:PRK09102 224 --------------KDKSVIRTVKARDLWAKILETRIETGEPYLLFIDNVNRAlpEVYKDLGlKVKASNLCSEItlptgI 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 434 EYTSKDEVAVCNLASLALNMYVTPEHTYDFeklaevTKVIVRNLNKIID--INYYP--IPEAHLSNKRHRPIGIGVQGLA 509
Cdd:PRK09102 290 DHLGEDRTAVCCLSSLNLEYYDEWKDTDAF------IEDLMRFLDNVLQdfIDKAPdeMERAKYSAMRERSVGLGVMGFH 363
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 510 DAFILMRYPFESPEAQLLNKQIFETIYYGALEASCDLAKEYGPyetyegspvskgilqydmwnvtPTDLwdwkllkekiA 589
Cdd:PRK09102 364 SYLQSKMIPFESVMAKQWNKKIFKHIREQADKASKELAKEKGE----------------------CPDA----------A 411
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 590 KYGI--RNSLLIAPMPTASTAQILGN-NESIEPYTSNIYTRRVLSGEFQIVNPHLLKDLTERGLWNEEMKNQIIACNGSI 666
Cdd:PRK09102 412 GYGVmrRFSTKMAIAPTASISIILGNtSPGIEPIAANYYTHKTLKGSFTVKNKYLEKLLEEKGKDTDEVWSSILTNEGSV 491
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 667 QSIPEIPEDLKQLYKTVWEISQKTVLKMAAERGAFIDQSQSLNIHI-AEPNYGKLTSMHFYGWKQGLKTgMYYLRTRPAA 745
Cdd:PRK09102 492 QHLDFLSEEEKDVFKTAFEIDQRWIIELAADRQKYIDQAQSLNLFLpANVPKRDLNKLHFEAWKKGVKS-LYYQRSKSVQ 570
|
|
| PRK07088 |
PRK07088 |
ribonucleoside-diphosphate reductase subunit alpha; |
5-742 |
4.82e-126 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 180831 [Multi-domain] Cd Length: 764 Bit Score: 395.33 E-value: 4.82e-126
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 5 KRDGRQERVMFDKITSRIQKLCYGLnmDFVDPAQITMKVIQGLYSGVTT-----------VELDTLAAETAATLTTK--H 71
Cdd:PRK07088 7 KRDGQYEPLQVEKTKKMVKLACEGL--YGCDPLELELDSRIQFRDGMTTkeiqksliqtaIEKVIQNSKDNNGNNTKktN 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 72 PDYAILAARIAVSNLHKETKK---VFSDVMEDLYNYINP--HNGRHSPMV--ASSTLEIvmahkDRLNSAIIYDRDFSYN 144
Cdd:PRK07088 85 PNWQYVAARLYVFDLYKEARInrhYNSFGYGDYYELVKKlvEEKLYGEYLlqNYSKEEI-----KELEKYIKPERDFLFN 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 145 YFGFKTLERSYLLK-INGKVAERPQHMLMRVSVGIHKEDIDA-----AIETYNLLSEKWFTHASPTLFNAGTNRPQLSSC 218
Cdd:PRK07088 160 YEGLKLLADRYLVKgFNREILELPQERFMGIAMHLAIPEGKEkrvyyAKKFYDLLSELKATVATPTLSNAGTPFYQLSSC 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 219 FLlSMKDDSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGnKRPGAFA 298
Cdd:PRK07088 240 FI-SVVDDNLWSIYDVNQKFAQVSKHGGALGIYTGKIRALNSEIRGFKNASGGVIPWIKLYNDTAIAVDQLG-KRKGGAA 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 299 IYLEPWHLDIFEFLDLKKNTGKEEQRARDLFFALWIPDLFMKRVETNQDWSLMCPNECPGL---------DEVWGEEFEK 369
Cdd:PRK07088 318 ITLDIWHKDIPEFLDLKTNNGDDRRKAHDIFPGVSYPDLFMKRLEKRENWSLFDPHEIKKVkgysledyyDEEDRKEFTK 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 370 LYESYEKQGRV-RKVVKAQQLWYAIIESQTETGTPYMLYKDSCNRKSNQQNLGTIKCSNLCTEIVEYTSKDEVA------ 442
Cdd:PRK07088 398 KYLECEEDTNIpRRTVPVLDIMKKIMKSAVETGTPFIFFRDTVNKANPNKHKGMIYSSNLCHEIAQNMSESELLeeeiid 477
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 443 -----------------VCNLASLALNmyvtpehTYDFEKLAEVTKVIVRNLNKIIDINYYPIPEAHLSNKRHRPIGIGV 505
Cdd:PRK07088 478 engyyevvqkikagdmvTCNLNSIVLG-------NVDDEELEEVIPTQIRMLDNVISLNYYPVPEAEITSDKYRAIGLGT 550
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 506 QGLADAFILMRYPFESPEAQLLNKQIFETIYYGALEASCDLAKEYGPYETYEGSPVSKGilqyDMWNVTPTDLWDWKLLK 585
Cdd:PRK07088 551 SGYHHMLANNKIRWESDEHIKFADKIYEEIAYYAIKASMELAKEKGSYPAFKGSEWETG----KYFERRGYNSERWKKLK 626
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 586 EKIAKYGIRNSLLIAPMPTASTAQILGNNESIEPytsnIYTRrvlsgefqivnphllkdltergLWNEEMKnqiiacnGS 665
Cdd:PRK07088 627 EEIKKYGMRNGYITAVAPTGSTSNIANTTAGIDP----VFKR----------------------FFMEEKK-------GS 673
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 666 IqsIPEIPEDLKQ----LYKTVWEISQKTVLKMAAERGAFIDQSQSLNIHIAePNYGKLTSMHFY--GWKQGLKTgMYYL 739
Cdd:PRK07088 674 F--TPKTAPDLNEenfwYYKEAHTIDQQWSIKACGVRQRHIDQAQSFNLYIT-PEYKAKQILNLYieAWKQGVKT-IYYV 749
|
...
gi 61557388 740 RTR 742
Cdd:PRK07088 750 RNK 752
|
|
| PRK12364 |
PRK12364 |
ribonucleoside-diphosphate reductase subunit alpha; |
72-742 |
1.35e-121 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 237077 [Multi-domain] Cd Length: 842 Bit Score: 385.64 E-value: 1.35e-121
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 72 PDYAILAARIAVSNLHKETKKV--------FSDVM-----EDLY-NYINPHNGRHspmvasstlEIvmahkDRLNSAIIY 137
Cdd:PRK12364 165 PDWEFIAARLLMLQFSKKLGKSleklgihsFYDKIkylteEGLYgSYILEHYSRE---------EI-----EEAAGFIDP 230
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 138 DRDFSYNYFGFKTLERSYLLKI-NGKVAERPQHMLMrvSVGIH------KEDIDAAIETYNLLSEKWFTHASPTLFNAGT 210
Cdd:PRK12364 231 ERDKLFTYSGLDLLLKRYVIRThSHEPLESPQEMFL--GIALHlampekQDRMGWVKRFYDMLSKLKVTMATPTLSNARK 308
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 211 NRPQLSSCFLLSMKDdSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGG 290
Cdd:PRK12364 309 PFHQLSSCFIDTVPD-SLDGIYRSIDNFAQVSKFGGGMGLYFGKVRAVGSNIRGFQGVAGGVIRWIKLANDTAVAVDQLG 387
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 291 nKRPGAFAIYLEPWHLDIFEFLDLKKNTGKEEQRARDLFFALWIPDLFMKRVE--TNQDWSLMCPNECP-----GLDEVW 363
Cdd:PRK12364 388 -MRQGAVAVYLDVWHKDIPEFLQLRTNNGDDRMKAHDVFPAVCYPDLFWKMVRddINQSWYLFCPHEILtvkgyALEDYY 466
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 364 GEEFEKLYESYEKQGRV-RKVVKAQQLWYAIIESQTETGTPYMLYKDSCNRKSNQQNLGTIKCSNLCTEI---------- 432
Cdd:PRK12364 467 GEEWEKRYLDCVNDARIsKRSIPIKDLVRLILKSAVETGTPFTFNRDTVNRANPNKHKGMIYCSNLCTEIaqnmsaietv 546
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 433 -------------VEYTSKDEVAVCNLASLAL-NMYVTpehtyDFEKLAEVTKVIVRNLNKIIDINYYPIPEAHLSNKRH 498
Cdd:PRK12364 547 steietedgdtvvVTTTRPGDFVVCNLASLSLgNIDLE-----DEEELEEVVRTVVRALDNVIDLNFYPVPYAQITNKRY 621
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 499 RPIGIGVQGLADAFILMRYPFESPEAQLLNKQIFETIYYGALEASCDLAKEYGPYETYEGSPVSKGILqYDMWNVTPTdl 578
Cdd:PRK12364 622 RSIGLGVSGYHHALAKNGIRWESEEHLEFADRVFERINYAAIKASMEIAKEKGAYGYFEGSDWQTGAY-FRKRGYTSE-- 698
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 579 wDWKLLKEKIAKYGIRNSLLIAPMPTASTAQILGNNESIEPytsniytrrvlsgefqIVNPHLLkdlterglwnEEMKNQ 658
Cdd:PRK12364 699 -EWQRLAREVAENGMRNAYLLAVAPTSSTSIIAGTTAGVDP----------------VMKRYFL----------EEKKGA 751
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 659 IIAcngsiQSIPEIPEDLKQLYKTVWEISQKTVLKMAAERGAFIDQSQSLNIHIA-EPNYGKLTSMHFYGWKQGLKTgMY 737
Cdd:PRK12364 752 LMP-----RVAPELSDKTFWLYKNAHLIDQKWSIRAAGVRQRHIDQAQSVNLYITnEFTMRQVLDLYLLAWEEGVKT-IY 825
|
....*
gi 61557388 738 YLRTR 742
Cdd:PRK12364 826 YVRSK 830
|
|
| NrdJ_Z |
TIGR02504 |
ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; This model represents a ... |
151-733 |
8.91e-101 |
|
ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; This model represents a group of adenosylcobalamin(B12)-dependent ribonucleotide reductases (Class II RNRs) related to the characterized species from Pyrococcus, Thermoplasma, Corynebacterium, and Deinococcus. RNR's are responsible for the conversion of the ribose sugar of RNA into the deoxyribose sugar of DNA. This is the rate-limiting step of DNA biosynthesis. This model identifies genes in a wide range of deeply branching bacteria. All are structurally related to the class I (non-heme iron dependent) RNRs. In most species this gene is known as NrdJ, while in mycobacteria it is called NrdZ. [Purines, pyrimidines, nucleosides, and nucleotides, 2'-Deoxyribonucleotide metabolism]
Pssm-ID: 274168 [Multi-domain] Cd Length: 575 Bit Score: 323.12 E-value: 8.91e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 151 LERSYLLKI-NGKVAERPQHMLMRVSVGI-HKEDIDA-------AIETYNLLSEKWFTHASPTLFN-AGTNRPQLSSCFL 220
Cdd:TIGR02504 2 LAARYLLKDeDGNIIESPEDLFRRVARALaAAEDKYNspvwkqwYERFYDLMVNLGFIPNSPTLMNaGGTRLGQLSACFV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 221 LSMKDDSiEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGnKRPGAFAIY 300
Cdd:TIGR02504 82 LPVEDSM-EDIFEALKEAALIFKRGGGVGYNFSTLRPKGDLVSGTGGVASGPVSFMRVFDSAAGVVKQGG-TRRGAQMGI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 301 LEPWHLDIFEFLDLKKNTGKEEQrardlF-FALWIPDLFMKRVETNQDWSLMCPNEcpgldevwgeefeklyesyekqgR 379
Cdd:TIGR02504 160 LDVWHPDIEEFIEAKAKEGKLQN-----FnISVGVTDEFMEAVENDEEYELRNPRT-----------------------G 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 380 VRKVVKAQQLWYAIIESQTETGTPYMLYKDSCNRKSNQQNLGTIKCSNLCTEI--VEYTSkdevavCNLASLAL-NMYVT 456
Cdd:TIGR02504 212 EYKEVDARELWDKIVESAWKSAEPGVLFIDTINKWHTCPYGGRINATNPCGEQplLPYES------CNLGSINLaKFVKN 285
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 457 P---EHTYDFEKLAEVTKVIVRNLNKIIDINYYPIPEAHLSNKRHRPIGIGVQGLADAFILMRYPFESPEAQLLNKQIFE 533
Cdd:TIGR02504 286 DfgdEASFDFERLREVVRLATRFLDNVIDINVFPLPEIAENTKKTRRIGLGIMGLADLLIKLGIPYDSEEARELAEEVME 365
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 534 TIYYGALEASCDLAKEYGPYETYEGSPVSKGILQYDMWNVT-PTDLWDWkllkekIAKYGIRNSLLIAPMPTASTAQILG 612
Cdd:TIGR02504 366 FIADAAYRASAELAKERGAFPLYDASKYPMGRAMGARIPSAlPAEIREA------IRKYGIRNAQLTTIAPTGTISLIAG 439
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 613 NNESIEPYTSNIYTRRVL-SGEFQIVNPHLLKDLTERGLWNEEmKNQIIACNGSIQSIPEiPEDLKQLYKTVWEISQKTV 691
Cdd:TIGR02504 440 TSSGIEPVFALVYFRNVTvGGELLEVNPLVELALRELGYYSDE-IVKYVDEKGTVEGAPG-PEELPKVFVTAMDISPEDH 517
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|..
gi 61557388 692 LKMAAERGAFIDQSQSLNIHIaePN----------YgkltsmhFYGWKQGLK 733
Cdd:TIGR02504 518 VLMQAAIQPWVDSSISKTINM--PSdatvedvkavY-------LEAWKLGLK 560
|
|
| nrdA |
PHA02572 |
ribonucleoside-diphosphate reductase subunit alpha; Provisional |
1-756 |
1.85e-100 |
|
ribonucleoside-diphosphate reductase subunit alpha; Provisional
Pssm-ID: 222883 [Multi-domain] Cd Length: 753 Bit Score: 327.45 E-value: 1.85e-100
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 1 MHVIKRDGRQERVMFDKITSRIQKLCYGLNmdfVDPAQITMKVIQGLYSGVTTVEL-DTLAAETAATLTTKHPDYAILAA 79
Cdd:PHA02572 4 INVIKSSGVSQPFDLEKIHKVLEWACEGTG---VDPSELEENSKIQLRDGMTTKDIqEILIKSAADLISVEEPDYQYVAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 80 RIAVSNLHKETKKVFSdvMEDLYNYI--NPHNGRHSPMVAS--STLEIvmahkDRLNSAIIYDRDFSYNYFGFKTLERSY 155
Cdd:PHA02572 81 RLLMFALRKQVYGQFE--PPSFIDHIskCVNEGKYDPEILSkySAEEI-----TYLESFIDHDRDFEFTYAGAMQLKEKY 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 156 LLK--INGKVAERPQHMLMRVSVGIHKED-----IDAAIETYNLLSEKWFThaSPTLFNAGTNRP--QLSSCFLLSMkDD 226
Cdd:PHA02572 154 LVQdrSTGEIYETPQFAYMLIAMALHQDEpkedrLEHVIRFYNAVSTRKIS--LPTPIMAGVRTPtrQFSSCVVIES-GD 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 227 SIEGIYDTLKQCA-LISKSAGgIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGnKRPGAFAIYLEPWH 305
Cdd:PHA02572 231 SLDSINKTAMAIVkYISKRAG-IGINAGMIRAEGSKIRGGEVRHTGVIPFWKHFQTAVKSCSQGG-IRGGAATAYYPIWH 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 306 LDIFEFLDLKKNTGKEEQRARDLFFALWIPDLFMKRVETNQDWSLMCPNECPGldEVWG------EEFEKLYESYEKQGR 379
Cdd:PHA02572 309 LEVEDLLVLKNNKGVEENRIRHLDYGVQINDLMYERFIKNDYITLFSPHDVGG--ELYDayfadqDRFRELYEALEKDPS 386
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 380 VR-KVVKAQQLWYAIIESQTETGTPYMLYKDSCNRKSNqqNLGTIKCSNLCTEIVEYTS-------KDEVAVCNLASLAL 451
Cdd:PHA02572 387 VRkKRIKAQELFLLLLKERSETGRIYIMFIDHCNNHSP--FKDPIRQSNLCCEIALPTKplnhidgEGEIALCTLSAIVL 464
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 452 NMYVTPEhtyDFEKLAEvtkVIVRNLNKIIDINYYPIPEAhLSNKRHRPIGIGVQGLAdAFILMRY-PFESPEAQLLNKq 530
Cdd:PHA02572 465 GNFEDQD---EIEELAE---VAVRALDNLLDYQDYPVPAA-LKAKKRRSLGVGVTNYA-HYLAKNFaSYEDANADLVHE- 535
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 531 IFETIYYGALEASCDLAKEYGPYETYEGSPVSKGILQYDMWN------VTPTDLWDWKLLKEKIAKYGIRNSLLIAPMPT 604
Cdd:PHA02572 536 LFERLQYYLIKASNKLAKEKGACEYFSDTKYSRGELPIDWYKkkvdelVAPKYNCDWESLREDLKKYGIRNSTLSALMPC 615
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 605 ASTAQILGNNESIEPYTSNIYTRRVLSGEFqivnphllkdlterglwneemkNQIiacngsiqsIPEIpEDLKQLYKTVW 684
Cdd:PHA02572 616 ESSSQVSNSTNGIEPPRGPVSIKKSKEGPF----------------------NQV---------VPNV-ETLKDLYDLLW 663
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 685 EISQKT---VLKMAAERGAFIDQSQSLNIHIAEPNY--GKL-TSMHF----YGWKQGLKTgMYYLRTRPAANPIQFTLNK 754
Cdd:PHA02572 664 DLAKKGnkgYLTQVAIMQKFVDQAISANTSYDPENYpnGKVpMSVMLddllYFYYYGGKT-LYYHNTRDGKGTEDYEIET 742
|
..
gi 61557388 755 EK 756
Cdd:PHA02572 743 PK 744
|
|
| RNR_II_dimer |
cd02888 |
Class II ribonucleotide reductase, dimeric form; Ribonucleotide reductase (RNR) catalyzes the ... |
188-620 |
2.64e-100 |
|
Class II ribonucleotide reductase, dimeric form; Ribonucleotide reductase (RNR) catalyzes the reductive synthesis of deoxyribonucleotides from their corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. RNRs are separated into three classes based on their metallocofactor usage. Class I RNRs, found in eukaryotes, bacteria, and bacteriophage, use a diiron-tyrosyl radical. Class II RNRs, found in bacteria, bacteriophage, algae and archaea, use coenzyme B12 (adenosylcobalamin, AdoCbl). Class III RNRs, found in anaerobic bacteria, bacteriophage, and archaea, use an FeS cluster and S-adenosylmethionine to generate a glycyl radical. Many organisms have more than one class of RNR present in their genomes. All three RNRs have a ten-stranded alpha-beta barrel domain that is structurally similar to the domain of PFL (pyruvate formate lyase). Class II RNRs are found in bacteria that can live under both aerobic and anaerobic conditions. Many, but not all members of this class are found to be homodimers. Adenosylcobalamin interacts directly with an active site cysteine to form the reactive cysteine radical.
Pssm-ID: 153089 [Multi-domain] Cd Length: 464 Bit Score: 318.02 E-value: 2.64e-100
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 188 ETYNLLSEKWFTHASPTLFNAGTN-RPQLSSCFLLSMKDDSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTN 266
Cdd:cd02888 3 EFFYLLLSQGFIPNSPTLMNAGTGeLGQLSACFVLPVEDDSIEGIFDALKEAALIFKRGGGVGYNFSRLRPKGDIVKSTG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 267 GNSNGLVPMLRVYNNTARYVDQGGnKRPGAFAIYLEPWHLDIFEFLDLKKntgKEEQRARDLFFAL--WIPDLFMKRVET 344
Cdd:cd02888 83 GVASGPVSFMRVFDAATGVIKQGG-TRRGANMGVLDVDHPDIEEFIDAKM---KEEKTVVLQNFNIsvAVTDAFMEAVEN 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 345 NQDWSLMCPNECPGldevwgeefeklyesyekqGRVRKVVKAQQLWYAIIESQTETGTPYMLYKDSCNRKSNQQNLGTIK 424
Cdd:cd02888 159 DEPWELRNPREPDT-------------------GKVYRTVPARELWDKIVEAAWDSADPGVLFIDTINRWNPLPGLGRIN 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 425 CSNLCTEIV--EYTSkdevavCNLASLALNMYV---TPEHTYDFEKLAEVTKVIVRNLNKIIDINYYPIPE-AHLSnKRH 498
Cdd:cd02888 220 ATNPCGEQPllPYES------CNLGSINLSKFVknpFGGASFDFERLREAVRLAVRFLDNVIDVNRYPLPEiAEET-KAT 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 499 RPIGIGVQGLADAFILMRYPFESPEAQLLNKQIFETIYYGALEASCDLAKEYGPYETYEGSpvskgilQYDMWNVTPTDL 578
Cdd:cd02888 293 RRIGLGVMGLADMLIKLGIPYDSEEARELAERIMSFIRDAAYRASAELAKERGPFPLFDAS-------RYLMLKVIVNAK 365
|
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 61557388 579 WDWKLLKEKIAKYGIRNSLLIAPMPTASTAQILGNNESIEPY 620
Cdd:cd02888 366 ELPDDVLEEIEKYGIRNAHLTTIAPTGTISLIAGTSSGIEPI 407
|
|
| PRK08665 |
PRK08665 |
vitamin B12-dependent ribonucleotide reductase; |
151-701 |
1.05e-85 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 236330 [Multi-domain] Cd Length: 752 Bit Score: 287.99 E-value: 1.05e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 151 LERSYLLK-INGKVAERPQHMLMRVSVGI--------HKEDIDA-AIETYNLLSEKWFTHASPTLFNAGTNRPQLSSCFL 220
Cdd:PRK08665 20 LEKRYLKKdEDGKPIETPEDMFRRVARTIaaaeliydSKADVEAlADRFYDLMTSLEFLPNSPTLMNAGRELGQLSACFV 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 221 LSMkDDSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGNKRPGAFAIy 300
Cdd:PRK08665 100 LPV-GDSIEEIFDAVKHAALIHKSGGGTGFSFSRLRPKNDRVGSTGGVASGPVSFMRVFDAATEAIKQGGTRRGANMGI- 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 301 LEPWHLDIFEFLDLKKNTGKeeqrARDLFFALWIPDLFMKRVETNQDWSLMCPNEcpgldevwgeefeklyesyekqGRV 380
Cdd:PRK08665 178 LRVDHPDIMEFITCKEDNGE----LTNFNISVAITEAFMEAVEADEEYDLINPRT----------------------GEV 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 381 RKVVKAQQLWYAIIESQTETGTPYMLYKDSCNRKSNQQNLGTIKCSNLCTE--IVEYTSkdevavCNLASLALNMYVTpE 458
Cdd:PRK08665 232 VGRLNAREVFDLIVEMAWENGEPGIVFIDRINRDNPTPHLGEIESTNPCGEqpLLPYES------CNLGSINLSKMVK-N 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 459 HTYDFEKLAEVTKVIVRNLNKIIDINYYPIPEAHLSNKRHRPIGIGVQGLADAFILMRYPFESPEAQLLNKQIFETIYYG 538
Cdd:PRK08665 305 GDVDWEKLREVVHLAVRFLDNVIDANKYPLPQIEEMTKGNRKIGLGVMGWADMLIQLGIPYDSEEAVELAEKVMKFIQDE 384
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 539 ALEASCDLAKEYGPYETYEGSpvskgilqydmwnvtptdLWDwkllKEKIAKYgiRNSLL--IAPMPTAStaqILGNNES 616
Cdd:PRK08665 385 AHAASRELAEERGPFPNYEGS------------------IYD----KDGLGPM--RNATVttIAPTGTIS---IIAGCSS 437
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 617 -IEPYTSNIYTRRVLSGEFQI-VNPHLLKDLTERGLWNEE-MKNqiIACNGSIQSIPEIPEDLKQLYKTVWEISQKTVLK 693
Cdd:PRK08665 438 gIEPLFALSFTRNVMDGERLVeVNPVFEAAAKEEGFYSEElMEK--IAEKGSIQDIDEVPEDVRRVFVTAHDISPEWHVR 515
|
....*...
gi 61557388 694 MAAergAF 701
Cdd:PRK08665 516 MQA---AF 520
|
|
| PRK09103 |
PRK09103 |
ribonucleoside-diphosphate reductase subunit alpha; |
1-749 |
8.50e-76 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 181649 [Multi-domain] Cd Length: 758 Bit Score: 261.07 E-value: 8.50e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 1 MHVIKRDGRQERVMFDKITSRIQKLCYGLNMdfVDPAQITMKV-IQgLYSGVTTVEL-DTLAAETAATLTTKHPDYAILA 78
Cdd:PRK09103 2 LLVTKRDGRTERINLDKIHRVITWAAEGLHN--VSVSQVELRShIQ-FYDGIKTSDIhETIIKAAADLISRDAPDYQYLA 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 79 ARIAVSNLHKETKKVFSDvmEDLYNYINP--HNGRHSPMVAS--STLEIvmahkDRLNSAIIYDRDFSYNYFGFKTLERS 154
Cdd:PRK09103 79 ARLAIFHLRKKAYGQFEP--PALYDHVVKmvEMGKYDKHLLEdyTEEEF-----DQMDTFIDHWRDMNFSYAAVKQLEGK 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 155 YLL--KINGKVAERPQHMLMRVSVGI-----HKEDIDAAIETYNLLSEkwFTHASPTLFNAGTNRP--QLSSCFLLSMkD 225
Cdd:PRK09103 152 YLVqnRVTGEIYESAQFLYILVAACLfsnypKETRLDYVKRFYDAVST--FKISLPTPIMSGVRTPtrQFSSCVLIEC-G 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 226 DSIEGIYDTlkQCALI---SKSAGgIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGnKRPGAFAIYLE 302
Cdd:PRK09103 229 DSLDSINAT--SSAIVkyvSQRAG-IGINAGRIRALGSPIRGGEAFHTGCIPFYKHFQTAVKSCSQGG-VRGGAATLFYP 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 303 PWHLDIFEFLDLKKNTGKEEQRARDLFFALWIPDLFMKRVETNQDWSLMCPNECPGLDEVW---GEEFEKLYESYEKQGR 379
Cdd:PRK09103 305 IWHLEVESLLVLKNNRGVEENRVRHMDYGVQINKLMYQRLIKGGDITLFSPSDVPGLYDAFfadQDEFERLYTKYEQDDS 384
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 380 VRK-VVKAQQLWYAIIESQTETGTPYMLYKDSCNRKSN-QQNLGTIKCSNLCTEIVEYT--------SKDEVAVCNLASL 449
Cdd:PRK09103 385 IRKkRVKAVELFSLMMQERASTGRIYIQNVDHCNTHSPfDPKVAPVRQSNLCLEIALPTkplndvndENGEIALCTLSAF 464
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 450 ALNmyvTPEHTYDFEKLAEvtkVIVRNLNKIIDINYYPIPEAHLSNKRHRPIGIGVQGLadAFIL----MRYPFESpeAQ 525
Cdd:PRK09103 465 NLG---AINSLDELEELAD---LAVRALDALLDYQDYPIPAAKRGAMGRRTLGIGVINF--AYYLakngVRYSDGS--AN 534
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 526 LLNKQIFETIYYGALEASCDLAKEYGPYETYEGSPVSKGILQYDMW-----NVTPTDL-WDWKLLKEKIAKYGIRNSLLI 599
Cdd:PRK09103 535 NLTHKTFEAIQYYLLKASNELAKEQGACPWFNETTYAQGILPIDTYkkdldAICNEPLhYDWETLREEIKTHGLRNSTLS 614
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 600 APMPTASTAQILGNNESIEPytsniytrrvlsgefqivnPhllkdlteRGLWN-EEMKNQIIAcngsiQSIPEIpEDLKQ 678
Cdd:PRK09103 615 ALMPSETSSQISNATNGIEP-------------------P--------RGYVSiKASKDGILK-----QVVPDY-ERLKD 661
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 679 LYKTVWEI-SQKTVLKMAAERGAFIDQSQSLNIHIaEPN---YGKLTSMHF-----YGWKQGLKTgMYYLRTRPAANPIQ 749
Cdd:PRK09103 662 AYELLWEMpNNDGYLQLVGIMQKFVDQSISANTNY-DPSrfpSGKVPMKQLlkdllTAYKFGVKT-LYYHNTRDGAEDAQ 739
|
|
| PRK06406 |
PRK06406 |
vitamin B12-dependent ribonucleotide reductase; |
190-712 |
1.58e-72 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 235796 [Multi-domain] Cd Length: 771 Bit Score: 252.46 E-value: 1.58e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 190 YNLLSEKWFTHASPTLFNAGTNRPQLSSCFLLSMkDDSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNS 269
Cdd:PRK06406 224 EEVMSNLKFVPNSPTLMNAGTKLGQLSACFVLPV-PDSIEGIFNALKYTAMIHKSGGGTGFSFSRLRPKDDIVASTKGVA 302
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 270 NGLVPMLRVYNNTARYVDQGGnKRPGAFAIYLEPWHLDIFEFLDLKKNtgkEEQRARDLFFALWIPDLFMKRVETNQDWS 349
Cdd:PRK06406 303 SGPLSFMRIFDVTTDVIKQGG-KRRGANMGILSYHHPDIMEFITSKDS---ENKVLSNFNISVAVTDEFFDKLDNDDYYP 378
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 350 LMCPnecpgldevwgeefeklyesyeKQGRVRKVVKAQQLWYAIIESQTETGTPYMLYKDSCNRKSNQQNLGTIKCSNLC 429
Cdd:PRK06406 379 LRNP----------------------RNGKEVKRIKARQVWDLIITQAWKTGDPGVIFLDEINRKNPVKNLGEIESTNPC 436
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 430 TE--IVEYTSkdevavCNLASLALNMYVTpEHTYDFEKLAEVTKVIVRNLNKIIDINYYPIPEAHLSNKRHRPIGIGVQG 507
Cdd:PRK06406 437 GEqpLLPYES------CNLGSINLSKFVE-NGKIDWDRLRETVHIATRFLDNVIDANKFPVPQIKEMTRMTRKIGLGVMG 509
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 508 LADAFILMRYPFESPEAQLLNKQIFETIYYGALEASCDLAKEYGPYETYEGSpvskgilqydmwnvtptdlwDWKllKEK 587
Cdd:PRK06406 510 FADMLIKLGIPYNSEEALEIAEKVMKFINEESHRASQKLAEERGVFPAWYGS--------------------EWE--KKG 567
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 588 IAkygIRNSLLIAPMPTASTAQILGNNESIEPYTSNIYTRRVLSGEFQI-VNPHLLKDLTERGLWNEEMKNQiIACNGSI 666
Cdd:PRK06406 568 IK---MRNSTTTTIAPTGTISIIAGCSSSIEPLFAIAFVRHVLNGQELLeVNPLFEEITRKRGLYSEELMRK-VAETGNL 643
|
490 500 510 520
....*....|....*....|....*....|....*....|....*.
gi 61557388 667 QSIpEIPEDLKQLYKTVWEISQKTVLKMAAERGAFIDQSQSLNIHI 712
Cdd:PRK06406 644 QNI-DVPEDIKRIFVTAHEIDPQWHVLMQATFQRYCDSGVSKTINL 688
|
|
| PRK08115 |
PRK08115 |
vitamin B12-dependent ribonucleotide reductase; |
190-654 |
3.33e-43 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 236152 [Multi-domain] Cd Length: 858 Bit Score: 168.48 E-value: 3.33e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 190 YNLLSEKWFTHASPTLFNAGTNRP-QLSSCFLLSMKDDSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGN 268
Cdd:PRK08115 160 YQELVNMNFVPAGRVLYGAGSKTDvTYFNCYVMPFVKDSREGISEHRKQVMEIMSRGGGVGTNGSTLRPRNTLARGVNGK 239
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 269 SNGLVPMLRVYNNTARYVDQGGNKRpGAFAIYLEPWHLDIFEFLD-----------LKKNTGKEE--------------- 322
Cdd:PRK08115 240 SSGSVSWLDDIAKLTHLVEQGGSRR-GAQMIMLADWHPDILEFIIskmqnprilryLLENTEDEQikrlvkeklkftpls 318
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 323 ---------------------------QRARDLF-----FALWIPDL-------------FMKRVETNQDWSLMCPN--- 354
Cdd:PRK08115 319 eveeamyqaivnykniegqggfdtkviKEAENKLrtggtYTVNNPEFltganisvcltkeFMEAVENDEEYELRFPDven 398
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 355 ----ECPGLDEVWGEEFEklYESYEKQG---RVRKVVKAQQLWYAIIESQTETGTPYMLYKDSCNRKSNQQNLG-TIKCS 426
Cdd:PRK08115 399 yteeEMEIYNEEWHEVGD--VREWEKMGypvRTYRKIKAKELWNLINICATYSAEPGIFFIDNANEMTNAKAYGqKVVAT 476
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 427 NLCTE--IVEYTskdevaVCNLASLAL-NMYVTPEHTYDFEKLAEVTKVIVRNLNKIIDINYYPIPEAHLSNKRHRPIGI 503
Cdd:PRK08115 477 NPCGEqpLAPYS------VCNLAAINLaNMADKETKTVDYEKLKRTVEVGVRMQDNVIDATPYFLEENKKQALGERRVGL 550
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 504 GVQGLADAFILMRYPFESPEAQLLNKQIFETIYYGALEASCDLAKEYGPYETYEGSP------VSKGILQYDMWNVTPTD 577
Cdd:PRK08115 551 GVMGLHDLLIYCETVYGSEEGNQLVDQIFETIATTAYRTSIELAKEKGSFPFLVGQTeeetakLREAFINTGYMKKMPED 630
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 61557388 578 lwdwklLKEKIAKYGIRNSLLIAPMPTASTAQILGNNESIEPYTSNIYTRRVLSGEFQIVNPHLLKDLTERGLWNEE 654
Cdd:PRK08115 631 ------IREDILKYGIRNSHLLTVAPTGSTGTMVGVSTGLEPYFSFSYYRSGRLGKFIEVKADIVQEYLDKHPEADE 701
|
|
| PRK08332 |
PRK08332 |
vitamin B12-dependent ribonucleotide reductase; |
426-686 |
1.50e-40 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 181392 [Multi-domain] Cd Length: 1740 Bit Score: 161.47 E-value: 1.50e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 426 SNLCTE--IVEYTSkdevavCNLASLALNMYVTPEHT----YDFEKLAEVTKVIVRNLNKIIDINYYPIPEAHLSNKRHR 499
Cdd:PRK08332 1294 SHNCGEepLYEYES------CNLASINLAKFVKYDENgkpyFDWDEYAYVIQKVAKYLDNAIDVNKFPLPEIDYNTKLTR 1367
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 500 PIGIGVQGLADAFILMRYPFESPEAQLLNKQIFETIYYGALEASCDLAKEYGPYETYEGSPVSKGIL------QYDMWNV 573
Cdd:PRK08332 1368 RIGVGMMGLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKYSVEAAKKRGTFPLYEKTEYPKGELpvegfyHPEIWNL 1447
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 574 TptdlwdWKLLKEKIAKYGIRNSLLIAPMPTASTAQILGNNESIEPYTSNIYTRRVLSGEFQIVNPHLLKDLTERGLWNE 653
Cdd:PRK08332 1448 P------WDKLVEEIKKYGVRNAMVTTCPPTGSVSMIADTSSGIEPIFALVYKKSVTVGEFYYVDPVFEAELKKRGLYSE 1521
|
250 260 270
....*....|....*....|....*....|...
gi 61557388 654 EMKNQIIACNGSIQSIPEIPEDLKQLYKTVWEI 686
Cdd:PRK08332 1522 ELLKKISDNYGSVQGLEEIPEDMQRVFVTALDI 1554
|
|
| PRK06556 |
PRK06556 |
vitamin B12-dependent ribonucleotide reductase; Validated |
177-676 |
2.25e-40 |
|
vitamin B12-dependent ribonucleotide reductase; Validated
Pssm-ID: 235828 [Multi-domain] Cd Length: 953 Bit Score: 160.14 E-value: 2.25e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 177 GIHKEDIDAAI---E-TYNLLSEKwFTHASPTLFNAGTN-RPQLSSCFLLSMkDDSIEGIYDTLKQCALISKSAGGIGVA 251
Cdd:PRK06556 107 GYFATEEDAEIfehElTWLLLHQK-FSFNSPVWFNVGTEsPQQVSACFILSV-DDSMESILNWYKEEGMLFKGGSGTGTN 184
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 252 VSCIRATGSYIAGtNGNSNGLVPMLRVYNNTARYVDQGGNKRPGAFAIYLEPWHLDIFEFLDLKkntGKEEQRARDLFFA 331
Cdd:PRK06556 185 LSRIRSSKELLSG-GGTASGPVSFMRGADASAGTIKSGGATRRAAKMVILDVDHPDIEEFIETK---AKEEDKIRALRDA 260
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 332 LWIPDL----------------------FMKRVETNQDWSLMcpnecpgldevwgeefeklyesYEKQGRVRKVVKAQQL 389
Cdd:PRK06556 261 GYDMDLggeayssvqyqnannsvrvsdeFMRAVENDGEFGLR----------------------ARTDGEVIETVDAKEL 318
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 390 WYAIIESQTETGTPYMLYKDSCNRKSNQQNLGTIKCSNLCTeivEYTSKDEVAvCNLASLALNMYVTPEHTYDFEKLAEV 469
Cdd:PRK06556 319 FRKIAEAAWECADPGIQYDDTINDWHTCPESGRINASNPCS---EYMFLDNSS-CNLASLNLMKFLRDDGTFDVESFRHA 394
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 470 TKVIVRNLNKIIDINYYPIPEAHLSNKRHRPIGIGVQGLADAFILMRYPFESPEAQLLNKQIFETIYYGALEASCDLAKE 549
Cdd:PRK06556 395 VELVITAMEISICFADFPTEKIARNTRAFRQLGLGYANLGALLMATGLPYDSDGGRALAAAITSLMTGEAYRRSAELAGV 474
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 550 YGPYETYE-GSPVSKGILQ--------YDMWNVTPTDLWD-----WKLLKEKIAKYGIRNS--LLIAP-------MPTAS 606
Cdd:PRK06556 475 VGPFEGYArNAEPHLRVMRkhaaandaIRPLGEVDAALLEaakeaWDDALELGEKNGYRNAqaSVLAPtgtigfmMDCDT 554
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 61557388 607 TaqilgnneSIEPYTSNI-YTRRVLSGEFQIVNPHLLKDLTERGlWNEEMKNQI---IACNGSIQSIPEI-PEDL 676
Cdd:PRK06556 555 T--------GIEPDFALVkYKKLVGGGSMKIVNQTVPRALKKLG-YSEEQIEAIveyIAEHGHIEGAPGLkPEHY 620
|
|
| PRK06948 |
PRK06948 |
ribonucleotide reductase-like protein; Provisional |
246-636 |
7.24e-29 |
|
ribonucleotide reductase-like protein; Provisional
Pssm-ID: 180772 [Multi-domain] Cd Length: 595 Bit Score: 122.60 E-value: 7.24e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 246 GGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGNKRPGAFAIyLEPWHLDIFEFLDLKKNtgkeeqRA 325
Cdd:PRK06948 121 GGIGYDFSAIPPADARPDADHPDSPGVCAALDRFDRICAALPFRDGRRGAQMAV-LRCDHPDLLAFVAAKRG------RA 193
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 326 RDLFF--ALWIPDLFMKRVETNQDWSLMCPNE--------CPGLDEVWgeefekLYESyekqgrvrkvVKAQQLWYAIIE 395
Cdd:PRK06948 194 RWTTFnlSVAVTDAFMQAVAQDLPWALRHRAPprraaggaLRGADGAW------TYAT----------VPARHLWREIVS 257
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 396 SQTETGTPYMLYKDSCNRKSNQQNLGTIKCSNLCTE--IVEYTSkdevavCNLASLALNMYVT-P-----EHTYDFEKLA 467
Cdd:PRK06948 258 AARDSAEPGLLFVDTIDAANPLREHERIDATNPCGEqpLPPYGS------CVLGPIDLSRFVRhPfgvggEPRFDFAALA 331
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 468 EVTKVIVRNLNKIIDINYYPIPEAHLSNKRHRPIGIGVQGLADAFILMRYPFESPEAQLLNKQIFETIYYGALEASCDLA 547
Cdd:PRK06948 332 TAVRIQVRMLDNALDLTRWPLAAHAREARQKRRIGVGVTGLADALTMMRLRYDSPAAREMARYIASDLRHHAYAASAALA 411
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 548 KEYGPY-----ETYEGSPVSKGILQydmwnvtptdlwdwKLLKEKIAKYGIRNSLLIAPMPTASTAQILGNNES--IEPY 620
Cdd:PRK06948 412 AERGAYplcdpAAHLDALRAGPPLP--------------HAVCHAIARHGLRNSHLLSFAPVGSVSLAFGDNCSpgIEPA 477
|
410
....*....|....*.
gi 61557388 621 TSNIYTRRVLSGEFQI 636
Cdd:PRK06948 478 RAWIEHRPVRAGAGGA 493
|
|
| Ribonuc_red_lgN |
pfam00317 |
Ribonucleotide reductase, all-alpha domain; |
143-210 |
1.41e-21 |
|
Ribonucleotide reductase, all-alpha domain;
Pssm-ID: 459758 [Multi-domain] Cd Length: 75 Bit Score: 89.22 E-value: 1.41e-21
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 61557388 143 YNYFGFKTLERSYLLKI-NGKVAERPQHMLMRVSVGIH-----KEDIDAAIETYNLLSEKWFTHASPTLFNAGT 210
Cdd:pfam00317 1 LTYLGAKVLEDRYLLKDeDGELLETPQDMFMRVALALAgaeleEDRLELAEEFYDLLSSLKFLPATPTLMNAGT 74
|
|
| ATP-cone |
pfam03477 |
ATP cone domain; |
1-89 |
1.56e-13 |
|
ATP cone domain;
Pssm-ID: 397513 [Multi-domain] Cd Length: 86 Bit Score: 66.52 E-value: 1.56e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 1 MHVIKRDGRQERVMFDKITSRIQKLCYGLNMDFVDPA-QITMKVIQGLYSGVTTVELDtlaaETAATLTTKHPDYAILAA 79
Cdd:pfam03477 1 MKVIKRDGRREPFDKEKIRRAIEKACEKSPDQADELAsEVEEELEKSLEDGISTEEIQ----DLVEKTLAEHPDYAVARA 76
|
90
....*....|
gi 61557388 80 RIAVSNLHKE 89
Cdd:pfam03477 77 YILYRNLRKE 86
|
|
| PRK07562 |
PRK07562 |
vitamin B12-dependent ribonucleotide reductase; |
334-557 |
2.84e-07 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 236049 [Multi-domain] Cd Length: 1220 Bit Score: 54.20 E-value: 2.84e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 334 IPDLFMKRVETNQDWSLMcpnecpgldevwgeefeklyesYEKQGRVRKVVKAQQLWYAIIESQTETGTPYMLYKDSCNR 413
Cdd:PRK07562 403 VTDEFLRAVENDGDWNLT----------------------ARTDGKVAKTLKARDLWEKIGYAAWASADPGLQFNTTIND 460
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 414 KSNQQNLGTIKCSNLCTeivEYTSKDEVAvCNLASLAL-NMYVTPEHTYDFEKLAEVTKVIVRNLNKIIDINYYPIPE-A 491
Cdd:PRK07562 461 WHTCPASGPIRASNPCS---EYMFLDDTA-CNLASLNLlTFRDEDTKRFDVEAYEHACRLWTVVLEISVLMAQFPSKEiA 536
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 61557388 492 HLSNKrHRPIGIGVQGLADAFILMRYPFESPEAQLLNKQIFETIYYGALEASCDLAKEYGPYETYE 557
Cdd:PRK07562 537 ELSYE-FRTLGLGYANIGGLLMTMGIPYDSDEGRAICGALSAIMTGVAYATSAEMAKELGPFPGYE 601
|
|
| RNR_PFL |
cd00576 |
Ribonucleotide reductase and Pyruvate formate lyase; Ribonucleotide reductase (RNR) and ... |
239-543 |
9.89e-07 |
|
Ribonucleotide reductase and Pyruvate formate lyase; Ribonucleotide reductase (RNR) and pyruvate formate lyase (PFL) are believed to have diverged from a common ancestor. They have a structurally similar ten-stranded alpha-beta barrel domain that hosts the active site, and are radical enzymes. RNRs are found in all organisms and provide the only mechanism by which nucleotides are converted to deoxynucleotides. RNRs are separated into three classes based on their metallocofactor usage. Class I RNRs use a diiron-tyrosyl radical while Class II RNRs use coenzyme B12 (adenosylcobalamin, AdoCbl). Class III RNRs use an FeS cluster and S-adenosylmethionine to generate a glycyl radical. PFL, an essential enzyme in anaerobic bacteria, catalyzes the conversion of pyruvate and CoA to acteylCoA and formate in a mechanism that uses a glycyl radical.
Pssm-ID: 153083 [Multi-domain] Cd Length: 401 Bit Score: 51.76 E-value: 9.89e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 239 ALISKSAGGIGVAV--SCIRATGSYIAG-TNGNSNGLVPMLRVYNNTARYVDQGGNKRPGAFAIY----LEPWHLDIFEF 311
Cdd:cd00576 62 AASNQNGGGVSFARasSILSPYGSRDYAkGSGTETDAVEAADAFNLALKEVGQGNGRTGAATGFIggvhKGKGDKISQEF 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 312 LDLKKNTGKEEQRardlffaLWIPDLFMkRVEtnqdwslmcpnecpgldevwgeefEKLYEsyekqgrvrKVVKAQQLWY 391
Cdd:cd00576 142 LNLALANGGEGIP-------LNFPNLSV-RVS------------------------SDKPG---------ILVKAVELKQ 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 392 AIIESQTETGTPYMLYKDSCNrksnqqnLGTIkcsnlcteiveytskdevavcNLASLALNMYVTPEHTYDfEKLAEVTK 471
Cdd:cd00576 181 LIAEEARKTGSPGIFNDELCN-------LVSL---------------------NLARIMEKAINGSMDVVL-EELEELAF 231
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 61557388 472 VIVRNLNKIIDINYYPIPEAHLSNKRHRPIGIGVQGLADAFILMRYPF-ESPEAQLLNKQIFETIYYGALEAS 543
Cdd:cd00576 232 LAVRALDCVIDSHDERIPTIELGGDERRTVGLGIAGVADLLIKLGLEKvGDPEADDLAAELVDQLKKHLVKAT 304
|
|
| PRK08332 |
PRK08332 |
vitamin B12-dependent ribonucleotide reductase; |
137-292 |
5.65e-06 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 181392 [Multi-domain] Cd Length: 1740 Bit Score: 50.15 E-value: 5.65e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 137 YDRDFSYNYFGFKTLERSYLLKINGKVAERPQ---------HMLMRVSVGIHKEDIDaaiETYNLLSEKWFTHASPTLFN 207
Cdd:PRK08332 186 FDGKYSIGKYKLNKYHFERMVNLYRELAEKGKmkvsideflKMLERGEFDKYEKEIE---EYFRLMTNQIFMPNTPALIN 262
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 208 AGTNRPQLSSCFLLSMKDDsIEGIYDTLKQCALISKSAGGigvavsCIRATGSYIAGTNGNSN--GLVPMLRVYNNTARY 285
Cdd:PRK08332 263 SGRPLGMLSACFVVPIEDD-MESIMKAAHDVAMIQKAGGG------CIDGNAKIIFENEGEEHltTMAEMYERYKHLGEF 335
|
....*..
gi 61557388 286 VDQGGNK 292
Cdd:PRK08332 336 YDEEYNR 342
|
|
| PRK08332 |
PRK08332 |
vitamin B12-dependent ribonucleotide reductase; |
249-429 |
3.82e-04 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 181392 [Multi-domain] Cd Length: 1740 Bit Score: 44.37 E-value: 3.82e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 249 GVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGNKRPGAFAIyLEPWHLDIFEFLDLK-KNTGKEEQRARD 327
Cdd:PRK08332 757 GLNFSKLRPEGDIVGTTTGAASGPVSFMHLIDAVSDVIKQGGVRRGANMGI-LEIWHPDIEKFIHAKeKNIGTNVLSNFN 835
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61557388 328 LFFALWipDLFMKRVETNQDWSLMCPnecpgldevwgeefeklyesyeKQGRVRKVVKAQQLWYAIIESQTETGTPYMLY 407
Cdd:PRK08332 836 ISVGIW--EDFWEALKEGKKYPLINP----------------------RTGEVVKEIDPKSLFEELAYMAWAKADPGVIF 891
|
170 180
....*....|....*....|....
gi 61557388 408 KDSCNRKS--NQQNLGTIKCSNLC 429
Cdd:PRK08332 892 FDVINRRNvlKEAKGGPIRATNPC 915
|
|
| |
