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Conserved domains on  [gi|58865956|ref|NP_001012192|]
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EARP and GARP complex-interacting protein 1 [Rattus norvegicus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 12822048)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
39-299 3.79e-17

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 82.27  E-value: 3.79e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865956  39 YDNQIHIIDFDDENNIinkNVLLHQAGEIWHISASPaDKGVLATCynkTSDSRVQacaaVWRmpkelesgshespedpAS 118
Cdd:COG2319 182 DDGTVRLWDLATGKLL---RTLTGHTGAVRSVAFSP-DGKLLASG---SADGTVR----LWD----------------LA 234

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865956 119 TAQTLELLchldNGAQGNVACVVWEPmgDGKKVISL-ADSHILLWDLQPSSSQAVLASSAAlegrgqlKFTSGRWSPhhN 197
Cdd:COG2319 235 TGKLLRTL----TGHSGSVRSVAFSP--DGRLLASGsADGTVRLWDLATGELLRTLTGHSG-------GVNSVAFSP--D 299

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865956 198 CTQVATAS-DTTLRGWDTRSMSQIYCIEnAHGQLVRDLDFNPNKQYyLASCGDDCKVKFWDTRNvTEPVKTLEEHSHWVW 276
Cdd:COG2319 300 GKLLASGSdDGTVRLWDLATGKLLRTLT-GHTGAVRSVAFSPDGKT-LASGSDDGTVRLWDLAT-GELLRTLTGHTGAVT 376

                       250       260
                ....*....|....*....|....
gi 58865956 277 SVRYnhSHD-QLVLTGSSDSRVIL 299
Cdd:COG2319 377 SVAF--SPDgRTLASGSADGTVRL 398
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 227-373 4.16e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 66.20  E-value: 4.16e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865956 227 HGQLVRDLDFNPNKQYyLASCGDDCKVKFWDTRNvTEPVKTLEEHSHWVWSVRYnHSHDQLVLTGSSDSRVILSnmvsis 306
Cdd:cd00200   8 HTGGVTCVAFSPDGKL-LATGSGDGTIKVWDLET-GELLRTLKGHTGPVRDVAA-SADGTYLASGSSDKTIRLW------ 78

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 58865956 307 sepfghlvdddDVSDPEEHHtekskeplqdnviaTYEEHEDSVYAVDWASADPWLFASlSYDGRLVI 373
Cdd:cd00200  79 -----------DLETGECVR--------------TLTGHTSYVSSVAFSPDGRILSSS-SRDKTIKV 119
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
39-299 3.79e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 82.27  E-value: 3.79e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865956  39 YDNQIHIIDFDDENNIinkNVLLHQAGEIWHISASPaDKGVLATCynkTSDSRVQacaaVWRmpkelesgshespedpAS 118
Cdd:COG2319 182 DDGTVRLWDLATGKLL---RTLTGHTGAVRSVAFSP-DGKLLASG---SADGTVR----LWD----------------LA 234

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865956 119 TAQTLELLchldNGAQGNVACVVWEPmgDGKKVISL-ADSHILLWDLQPSSSQAVLASSAAlegrgqlKFTSGRWSPhhN 197
Cdd:COG2319 235 TGKLLRTL----TGHSGSVRSVAFSP--DGRLLASGsADGTVRLWDLATGELLRTLTGHSG-------GVNSVAFSP--D 299

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865956 198 CTQVATAS-DTTLRGWDTRSMSQIYCIEnAHGQLVRDLDFNPNKQYyLASCGDDCKVKFWDTRNvTEPVKTLEEHSHWVW 276
Cdd:COG2319 300 GKLLASGSdDGTVRLWDLATGKLLRTLT-GHTGAVRSVAFSPDGKT-LASGSDDGTVRLWDLAT-GELLRTLTGHTGAVT 376

                       250       260
                ....*....|....*....|....
gi 58865956 277 SVRYnhSHD-QLVLTGSSDSRVIL 299
Cdd:COG2319 377 SVAF--SPDgRTLASGSADGTVRL 398
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 39-299 9.71e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 79.69  E-value: 9.71e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865956  39 YDNQIHIIDFddENNIINKNVLLHqAGEIWHISASPADKGVLATCYNKTS---DSRVQACAAVWRMPKELESGSHESPED 115
Cdd:cd00200  29 GDGTIKVWDL--ETGELLRTLKGH-TGPVRDVAASADGTYLASGSSDKTIrlwDLETGECVRTLTGHTSYVSSVAFSPDG 105

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865956 116 P----ASTAQTLEL-------LCHLDNGAQGNVACVVWEPmgdGKKVI--SLADSHILLWDLQPSSSQAVLASSaalegr 182
Cdd:cd00200 106 RilssSSRDKTIKVwdvetgkCLTTLRGHTDWVNSVAFSP---DGTFVasSSQDGTIKLWDLRTGKCVATLTGH------ 176

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865956 183 gQLKFTSGRWSPhhNCTQVATAS-DTTLRGWDTRSMSQIYCIEnAHGQLVRDLDFNPNKqYYLASCGDDCKVKFWDTRNv 261
Cdd:cd00200 177 -TGEVNSVAFSP--DGEKLLSSSsDGTIKLWDLSTGKCLGTLR-GHENGVNSVAFSPDG-YLLASGSEDGTIRVWDLRT- 250

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 58865956 262 TEPVKTLEEHSHWVWSVRYnHSHDQLVLTGSSDSRVIL 299
Cdd:cd00200 251 GECVQTLSGHTNSVTSLAW-SPDGKRLASGSADGTIRI 287
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 227-373 4.16e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 66.20  E-value: 4.16e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865956 227 HGQLVRDLDFNPNKQYyLASCGDDCKVKFWDTRNvTEPVKTLEEHSHWVWSVRYnHSHDQLVLTGSSDSRVILSnmvsis 306
Cdd:cd00200   8 HTGGVTCVAFSPDGKL-LATGSGDGTIKVWDLET-GELLRTLKGHTGPVRDVAA-SADGTYLASGSSDKTIRLW------ 78

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 58865956 307 sepfghlvdddDVSDPEEHHtekskeplqdnviaTYEEHEDSVYAVDWASADPWLFASlSYDGRLVI 373
Cdd:cd00200  79 -----------DLETGECVR--------------TLTGHTSYVSSVAFSPDGRILSSS-SRDKTIKV 119
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 225-257 2.34e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.45  E-value: 2.34e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 58865956    225 NAHGQLVRDLDFNPNKQYyLASCGDDCKVKFWD 257
Cdd:smart00320   9 KGHTGPVTSVAFSPDGKY-LASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
225-257 7.98e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.94  E-value: 7.98e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 58865956   225 NAHGQLVRDLDFNPNKQYyLASCGDDCKVKFWD 257
Cdd:pfam00400   8 EGHTGSVTSLAFSPDGKL-LASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 204-260 1.84e-03

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 40.32  E-value: 1.84e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 58865956  204 ASDTTLRGWDTR----SMSQI---YCIENAHGQLVRDLDFNPNKQYYLASCGDDCKVKFWDTRN 260
Cdd:PTZ00420  94 SEDLTIRVWEIPhndeSVKEIkdpQCILKGHKKKISIIDWNPMNYYIMCSSGFDSFVNIWDIEN 157
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
39-299 3.79e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 82.27  E-value: 3.79e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865956  39 YDNQIHIIDFDDENNIinkNVLLHQAGEIWHISASPaDKGVLATCynkTSDSRVQacaaVWRmpkelesgshespedpAS 118
Cdd:COG2319 182 DDGTVRLWDLATGKLL---RTLTGHTGAVRSVAFSP-DGKLLASG---SADGTVR----LWD----------------LA 234

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865956 119 TAQTLELLchldNGAQGNVACVVWEPmgDGKKVISL-ADSHILLWDLQPSSSQAVLASSAAlegrgqlKFTSGRWSPhhN 197
Cdd:COG2319 235 TGKLLRTL----TGHSGSVRSVAFSP--DGRLLASGsADGTVRLWDLATGELLRTLTGHSG-------GVNSVAFSP--D 299

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865956 198 CTQVATAS-DTTLRGWDTRSMSQIYCIEnAHGQLVRDLDFNPNKQYyLASCGDDCKVKFWDTRNvTEPVKTLEEHSHWVW 276
Cdd:COG2319 300 GKLLASGSdDGTVRLWDLATGKLLRTLT-GHTGAVRSVAFSPDGKT-LASGSDDGTVRLWDLAT-GELLRTLTGHTGAVT 376

                       250       260
                ....*....|....*....|....
gi 58865956 277 SVRYnhSHD-QLVLTGSSDSRVIL 299
Cdd:COG2319 377 SVAF--SPDgRTLASGSADGTVRL 398
WD40 COG2319
WD40 repeat [General function prediction only];
132-373 6.37e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 81.50  E-value: 6.37e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865956 132 GAQGNVACVVWEPmgDGKKVISLA-DSHILLWDLQPSSSQAVLASSAAlegrgqlKFTSGRWSPhhNCTQVATAS-DTTL 209
Cdd:COG2319  76 GHTAAVLSVAFSP--DGRLLASASaDGTVRLWDLATGLLLRTLTGHTG-------AVRSVAFSP--DGKTLASGSaDGTV 144

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865956 210 RGWDTRSMSQIYCIEnAHGQLVRDLDFNPNKQYyLASCGDDCKVKFWDTRNvTEPVKTLEEHSHWVWSVRYnhSHD-QLV 288
Cdd:COG2319 145 RLWDLATGKLLRTLT-GHSGAVTSVAFSPDGKL-LASGSDDGTVRLWDLAT-GKLLRTLTGHTGAVRSVAF--SPDgKLL 219

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865956 289 LTGSSDSRVILSnmvsissepfghlvdddDVSDPEEhhtekskeplqdnvIATYEEHEDSVYAVDWaSADPWLFASLSYD 368
Cdd:COG2319 220 ASGSADGTVRLW-----------------DLATGKL--------------LRTLTGHSGSVRSVAF-SPDGRLLASGSAD 267


                ....*
gi 58865956 369 GRLVI 373
Cdd:COG2319 268 GTVRL 272
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 39-299 9.71e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 79.69  E-value: 9.71e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865956  39 YDNQIHIIDFddENNIINKNVLLHqAGEIWHISASPADKGVLATCYNKTS---DSRVQACAAVWRMPKELESGSHESPED 115
Cdd:cd00200  29 GDGTIKVWDL--ETGELLRTLKGH-TGPVRDVAASADGTYLASGSSDKTIrlwDLETGECVRTLTGHTSYVSSVAFSPDG 105

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865956 116 P----ASTAQTLEL-------LCHLDNGAQGNVACVVWEPmgdGKKVI--SLADSHILLWDLQPSSSQAVLASSaalegr 182
Cdd:cd00200 106 RilssSSRDKTIKVwdvetgkCLTTLRGHTDWVNSVAFSP---DGTFVasSSQDGTIKLWDLRTGKCVATLTGH------ 176

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865956 183 gQLKFTSGRWSPhhNCTQVATAS-DTTLRGWDTRSMSQIYCIEnAHGQLVRDLDFNPNKqYYLASCGDDCKVKFWDTRNv 261
Cdd:cd00200 177 -TGEVNSVAFSP--DGEKLLSSSsDGTIKLWDLSTGKCLGTLR-GHENGVNSVAFSPDG-YLLASGSEDGTIRVWDLRT- 250

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 58865956 262 TEPVKTLEEHSHWVWSVRYnHSHDQLVLTGSSDSRVIL 299
Cdd:cd00200 251 GECVQTLSGHTNSVTSLAW-SPDGKRLASGSADGTIRI 287
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 191-373 1.47e-14

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 73.52  E-value: 1.47e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865956 191 RWSPHHNctQVATAS-DTTLRGWDTRSMSQIYCIEN-----------------------------------------AHG 228
Cdd:cd00200  16 AFSPDGK--LLATGSgDGTIKVWDLETGELLRTLKGhtgpvrdvaasadgtylasgssdktirlwdletgecvrtltGHT 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865956 229 QLVRDLDFNPNKQyYLASCGDDCKVKFWDTRNvTEPVKTLEEHSHWVWSVRYNHShDQLVLTGSSDSRVILSNMVSISSE 308
Cdd:cd00200  94 SYVSSVAFSPDGR-ILSSSSRDKTIKVWDVET-GKCLTTLRGHTDWVNSVAFSPD-GTFVASSSQDGTIKLWDLRTGKCV 170

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 58865956 309 PF--GHlvdDDDVS----DPEEHH--------TEKSKEPLQDNVIATYEEHEDSVYAVDWaSADPWLFASLSYDGRLVI 373
Cdd:cd00200 171 ATltGH---TGEVNsvafSPDGEKllssssdgTIKLWDLSTGKCLGTLRGHENGVNSVAF-SPDGYLLASGSEDGTIRV 245
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 227-373 4.16e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 66.20  E-value: 4.16e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865956 227 HGQLVRDLDFNPNKQYyLASCGDDCKVKFWDTRNvTEPVKTLEEHSHWVWSVRYnHSHDQLVLTGSSDSRVILSnmvsis 306
Cdd:cd00200   8 HTGGVTCVAFSPDGKL-LATGSGDGTIKVWDLET-GELLRTLKGHTGPVRDVAA-SADGTYLASGSSDKTIRLW------ 78

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 58865956 307 sepfghlvdddDVSDPEEHHtekskeplqdnviaTYEEHEDSVYAVDWASADPWLFASlSYDGRLVI 373
Cdd:cd00200  79 -----------DLETGECVR--------------TLTGHTSYVSSVAFSPDGRILSSS-SRDKTIKV 119
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 134-257 1.29e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 61.58  E-value: 1.29e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865956 134 QGNVACVVWEPmgDGKKVISLA-DSHILLWDLQPSSSQAVLASSAAlegrgqlKFTSGRWSPHHNcTQVATASDTTLRGW 212
Cdd:cd00200 177 TGEVNSVAFSP--DGEKLLSSSsDGTIKLWDLSTGKCLGTLRGHEN-------GVNSVAFSPDGY-LLASGSEDGTIRVW 246

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 58865956 213 DTRSMSQIYCIEnAHGQLVRDLDFNPNKQYyLASCGDDCKVKFWD 257
Cdd:cd00200 247 DLRTGECVQTLS-GHTNSVTSLAWSPDGKR-LASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
39-260 2.93e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 58.38  E-value: 2.93e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865956  39 YDNQIHIIDFDDENNIInknVLLHQAGEIWHISASPaDKGVLATCynkTSDSRVQacaaVWRmpkelesgshespedpAS 118
Cdd:COG2319 224 ADGTVRLWDLATGKLLR---TLTGHSGSVRSVAFSP-DGRLLASG---SADGTVR----LWD----------------LA 276

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58865956 119 TAQTLELLchldNGAQGNVACVVWEPmgDGKKVISL-ADSHILLWDLQPSSSQAVLASSAAlegrgqlKFTSGRWSPhhN 197
Cdd:COG2319 277 TGELLRTL----TGHSGGVNSVAFSP--DGKLLASGsDDGTVRLWDLATGKLLRTLTGHTG-------AVRSVAFSP--D 341

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 58865956 198 CTQVATAS-DTTLRGWDTRSMSQIYCIEnAHGQLVRDLDFNPNKQYyLASCGDDCKVKFWDTRN 260
Cdd:COG2319 342 GKTLASGSdDGTVRLWDLATGELLRTLT-GHTGAVTSVAFSPDGRT-LASGSADGTVRLWDLAT 403
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 225-257 2.34e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.45  E-value: 2.34e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 58865956    225 NAHGQLVRDLDFNPNKQYyLASCGDDCKVKFWD 257
Cdd:smart00320   9 KGHTGPVTSVAFSPDGKY-LASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
225-257 7.98e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.94  E-value: 7.98e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 58865956   225 NAHGQLVRDLDFNPNKQYyLASCGDDCKVKFWD 257
Cdd:pfam00400   8 EGHTGSVTSLAFSPDGKL-LASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 263-299 1.55e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.14  E-value: 1.55e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 58865956    263 EPVKTLEEHSHWVWSVRYnHSHDQLVLTGSSDSRVIL 299
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAF-SPDGKYLASGSDDGTIKL 38
PTZ00420 PTZ00420
coronin; Provisional
 204-260 1.84e-03

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 40.32  E-value: 1.84e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 58865956  204 ASDTTLRGWDTR----SMSQI---YCIENAHGQLVRDLDFNPNKQYYLASCGDDCKVKFWDTRN 260
Cdd:PTZ00420  94 SEDLTIRVWEIPhndeSVKEIkdpQCILKGHKKKISIIDWNPMNYYIMCSSGFDSFVNIWDIEN 157
WD40 pfam00400
WD domain, G-beta repeat;
263-299 2.63e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.40  E-value: 2.63e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 58865956   263 EPVKTLEEHSHWVWSVRYnHSHDQLVLTGSSDSRVIL 299
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAF-SPDGKLLASGSDDGTVKV 37
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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